| Aspect of CCDC28B biology | Protein / gene | Primary cellular function | Subcellular localization | Key interactions / binding partners | Associated pathways / processes | Disease / phenotype associations | Key supporting citations |
|---|---|---|---|---|---|---|---|
| Core identity | Coiled-coil domain-containing protein 28B (CCDC28B); human UniProt Q9BUN5 | Non-enzymatic coiled-coil protein; current literature supports a regulatory/adaptor-like role rather than catalytic activity | Primarily linked to ciliary compartments | Broad association with BBS-related protein networks | Ciliogenesis; ciliary homeostasis | Considered a BBS-associated/modifier gene in ciliopathy literature | 2021 review/localization table (pqac-00000010); 2023 BBSome review context (pqac-00000006) |
| Positive regulator of ciliogenesis / cilium length | CCDC28B | Promotes ciliogenesis and positively regulates cilia length in somatic cells | Primary cilium, especially basal body/ciliary region | Functionally associated with BBS proteins and ciliary machinery | Primary cilium assembly and maintenance | Loss or depletion causes impaired ciliogenesis in mammalian cells and zebrafish; relevant to ciliopathies | 2024 CCDC28A paper summarizing prior CCDC28B evidence (pqac-00000001); 2025 ADGRV1/BBS-CCT paper citing positive regulation of cilia length (pqac-00000002) |
| BBS-associated modifier role | CCDC28B | Acts as a modifier/regulatory factor rather than a core BBSome subunit | Basal body / cilium-associated compartments | Associated with BBS proteins and BBSome-related networks | BBS-related ciliary biology | Variants/mutations associated with Bardet-Biedl syndrome; modifier effects discussed in BBS literature | 2021 BBS genotype-phenotype review (pqac-00000010); 2024 CCDC28A paper background (pqac-00000001); 2021 mouse selection paper summarizing BBS link (pqac-00000008) |
| Subcellular localization in ciliary structures | CCDC28B | Executes ciliary regulatory functions where cilia are assembled and maintained | Basal body and ciliary axoneme/cilium; low tissue specificity in review table | Likely engages local ciliary assembly and transport proteins | Ciliogenesis; ciliary trafficking | Mislocalization or loss expected to perturb ciliary structure/function | 2021 localization table listing basal body/cilium localization (pqac-00000010); 2021 brain cilia transcriptome review snippet noting localization (pqac-00000003) |
| KIF5B-regulated localization and possible nuclear shuttling | CCDC28B | Localization is dynamically regulated; KIF5B targeting causes nuclear accumulation of CCDC28B, suggesting extra-ciliary/nuclear potential | Cilium/basal body and nucleus under altered transport conditions | KIF5B | Ciliary homeostasis; possible nucleocytoplasmic trafficking-linked regulation | May connect ciliary defects to broader cell biological phenotypes | 2024 review on non-IFT kinesins stating KIF5B targeting leads to nuclear accumulation (pqac-00000000); 2023 KIF5B disease paper referencing direct interaction at ciliary basal body (pqac-00000009); 2023 evolutionary/nuclear roles review mentioning predicted/possible nuclear roles (pqac-00000006) |
| Relationship to BBSome / BBS-CCT chaperonin biology | CCDC28B | Functions in the broader BBS protein network that supports ciliary protein localization and homeostasis | Ciliary base / basal body-associated region | BBS proteins; BBS/CCT chaperonin-related machinery | BBSome-mediated trafficking; ciliary proteostasis | Dysfunction likely contributes to BBS-related cellular phenotypes | 2025 ADGRV1/BBS-CCT paper discussing CCDC28B as BBS-associated protein (pqac-00000002); 2015 BBS review summarizing BBS protein trafficking functions (pqac-00000012); 2023 BBSome review context (pqac-00000006) |
| Developmental and organ-specific ciliary roles | CCDC28B | Conserved ciliary regulator in vertebrate development | Somatic-cell cilia, including pronephric/renal cilia in zebrafish models | Ciliary assembly factors (functional association rather than direct binding established here) | Pronephron ciliogenesis; developmental cilia function | Perturbed pronephron ciliogenesis in zebrafish morphants; supports conserved developmental role | 2020 renal ciliopathy review summarizing zebrafish pronephron phenotype (pqac-00000004); 2024 CCDC28A paper background noting zebrafish and mammalian ciliogenesis defects (pqac-00000001) |
| Brain / lifespan expression dynamics | CCDC28B | Cilia-related transcript with age-dependent regulation in human brain regions | Inferred to function in neuronal primary cilia-related compartments | Not specifically defined in this dataset | Brain cilia biology; neurodevelopment/aging-linked ciliary regulation | Suggests possible relevance to age-dependent brain cilia physiology and neurological phenotypes seen in ciliopathies | 2021 human brain cilia transcriptome study identifying CCDC28B as age-regulated cilia transcript (pqac-00000003) |
| Immune-cell expression signature | CCDC28B | Upregulated marker-like transcript in regulatory B cells; exact mechanistic role remains unclear | Identified by scRNA-seq in Breg populations across organs | Co-expressed with Cd9, Ptpn22, Fcrl5, Zbtb20 in Bregs | Immunoregulatory programs; Breg-associated signatures; non-B10 Bregs linked to TGF-β pathways | No direct causal disease role established here, but suggests broader biology beyond classic ciliogenesis | 2021 single-cell Breg study (pqac-00000005) |
| Genetic / disease-association evidence beyond classic ciliopathy | CCDC28B | Candidate modifier or susceptibility gene based on genetic association studies | Not localization-focused | Not specified | Hypertension/aging-associated genetics in rat; adaptive selection signals in mouse populations | Candidate SNPs linked to hypertension and accelerated-senescence traits in OXYS rats; selective sweep overlaps in wild mice; relevance remains inferential for human disease | 2020 rat SNP study (pqac-00000007); 2021 wild mouse selection study (pqac-00000008) |


*Table: This table summarizes the major experimentally supported and review-supported functional properties of human CCDC28B, emphasizing its role in ciliogenesis, localization, interaction networks, pathways, and disease relevance. It is useful as a compact evidence map linking CCDC28B biology to Bardet-Biedl syndrome and broader ciliary processes.*