CD79A (Ig-alpha) is a type I membrane protein that forms the signaling heterodimer of the B-cell antigen receptor with CD79B (Ig-beta). Its extracellular and transmembrane regions help assemble and express the receptor complex, while its cytoplasmic immunoreceptor tyrosine-based activation motif provides phosphorylation-dependent docking sites for intracellular signaling proteins. Antigen recognition is supplied by the associated membrane immunoglobulin; CD79A contributes signal transmission and receptor organization rather than intrinsic kinase activity. This receptor unit supports B-cell development, activation and survival. Loss-of-function variants can disrupt the pro-B to pre-B transition and cause autosomal recessive agammaglobulinemia. An alternative splice transcript lacks part of the extracellular region.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0004888 transmembrane signaling receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: CD79A contributes to transmembrane signaling receptor activity as the Ig-alpha subunit of the BCR. Reason: The contributes_to flag explicitly asserts a complex-subunit contribution, not autonomous receptor activity. Human IgM-BCR structural evidence places CD79A/Ig-alpha in the Ig-alpha/Ig-beta signaling heterodimer, and human B-cell disruption experiments support its role in receptor assembly and surface expression. Defined CD79A phospho-ITAM/SYK binding assays establish a signaling scaffold contribution. Together these support the stated receptor-complex activity without assigning antigen recognition or intrinsic kinase catalysis to CD79A. The separately supported adaptor activity does not invalidate this weaker contribution claim. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN000371571 Β· CD79 ancestral node SUPPORTS TRANSFER The committed PTHR14334 PAINT slice records the GO:0004888 IBD at PTN000371571 with MGI:MGI:101774 experimental grounding. CD79A contributes to the receptor complex through its structural and signaling scaffold roles, independently corroborated by human target evidence. ACCEPT grades that inherited complex-subunit contribution; no erroneous node placement, target-specific loss or donor-count weakness is asserted. Supporting Evidence: PMID:39442513 We developed a time-resolved FΓΆrster resonance energy transfer (TR-FRET) assay to evaluate the interaction between the pITAMs of FCER1G, TYROBP, CD3G and CD79A (the Ig-Ξ± chain of the BCR) and the SYK-tSH2 domains (here and Bashore et al. 8). PMID:11909947 BLNK bound directly to phospho-Y204 PMID:35981043 IgM-BCR comprises two heavy chains, two light chains, and the IgΞ±/IgΞ² heterodimer. PMID:36426942 The BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of CD79A and CD79B. |
| GO:0004888 transmembrane signaling receptor activity | IEA GO_REF:0000120 | MODIFY | Summary: CD79A supplies a receptor-associated scaffold that recruits signaling proteins. Reason: Signaling receptor complex adaptor activity more precisely describes CD79A's own physical role: its phosphorylated ITAM docks SYK, and a separate phosphorylated non-ITAM site recruits BLNK. Defined human SYK/CD79A phosphopeptide assays support the ITAM interaction. PMID:11909947 supports the separate BLNK docking mechanism without assigning its study residue numbering to human. This is a lateral role refinement to GO:0030159, not an is_a descendant of receptor activity; it rests on the demonstrated adaptor function, not on ordinary relationship metadata. CD79A's valid contribution to whole-receptor activity remains separately represented. No autonomous antigen recognition or kinase activity is asserted. Proposed replacements: signaling receptor complex adaptor activity Supporting Evidence: PMID:39442513 We developed a time-resolved FΓΆrster resonance energy transfer (TR-FRET) assay to evaluate the interaction between the pITAMs of FCER1G, TYROBP, CD3G and CD79A (the Ig-Ξ± chain of the BCR) and the SYK-tSH2 domains (here and Bashore et al. 8). PMID:11909947 BLNK bound directly to phospho-Y204 |
| GO:0004888 transmembrane signaling receptor activity | ISS GO_REF:0000024 | ACCEPT | Summary: CD79A contributes to transmembrane signaling receptor activity as the Ig-alpha subunit of the BCR. Reason: The contributes_to flag explicitly asserts a complex-subunit contribution, not autonomous receptor activity. Human IgM-BCR structural evidence places CD79A/Ig-alpha in the Ig-alpha/Ig-beta signaling heterodimer, and human B-cell disruption experiments support its role in receptor assembly and surface expression. Defined CD79A phospho-ITAM/SYK binding assays establish a signaling scaffold contribution. Together these support the stated receptor-complex activity without assigning antigen recognition or intrinsic kinase catalysis to CD79A. The separately supported adaptor activity does not invalidate this weaker contribution claim. The original ISS source identifier is preserved; the conclusion is independently supported by human target evidence rather than an unverified reconstruction of that donor record. Supporting Evidence: PMID:39442513 We developed a time-resolved FΓΆrster resonance energy transfer (TR-FRET) assay to evaluate the interaction between the pITAMs of FCER1G, TYROBP, CD3G and CD79A (the Ig-Ξ± chain of the BCR) and the SYK-tSH2 domains (here and Bashore et al. 8). PMID:11909947 BLNK bound directly to phospho-Y204 PMID:35981043 IgM-BCR comprises two heavy chains, two light chains, and the IgΞ±/IgΞ² heterodimer. PMID:36426942 The BCR consists of surface-bound Ig and a heterodimeric signaling unit comprised of CD79A and CD79B. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: CD79A interaction reported by PMID:25416956; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: CD79A interaction reported by PMID:32296183; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: CD79A interaction reported by PMID:40205054; generic binding is uninformative as a functional annotation. Reason: The publication-linked interaction involving CD79A is retained as an assay observation, but bare protein binding does not identify its biological activity. This row is removed under the current protein-binding policy, not because the interaction is false or because another row duplicates it. The screen or affinity experiment alone does not justify transferring the partner's function or assigning an endogenous B-cell complex. Supporting Evidence: |
| GO:0005771 multivesicular body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: CD79A can accompany the B-cell receptor into the endocytic pathway. Reason: The mouse ortholog was detected with anti-Ig-alpha immunogold in multivesicular MHC-II compartments after BCR stimulation (PMID11854359, Fig. 5C). This supports the conserved conditional receptor-trafficking location. It is not a new human imaging experiment, a constitutive residence claim, or an assignment of vesicle-biogenesis activity. Supporting Evidence: PMID:11854359 The multivesicular MIICs also contain Ig Ξ± |
| GO:0005771 multivesicular body | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: CD79A can accompany the B-cell receptor into the endocytic pathway. Reason: The mouse ortholog was detected with anti-Ig-alpha immunogold in multivesicular MHC-II compartments after BCR stimulation (PMID11854359, Fig. 5C). This supports the conserved conditional receptor-trafficking location. It is not a new human imaging experiment, a constitutive residence claim, or an assignment of vesicle-biogenesis activity. Supporting Evidence: PMID:11854359 The multivesicular MIICs also contain Ig Ξ± |
| GO:0005886 plasma membrane | IDA PMID:36426942 Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness... | ACCEPT | Summary: CD79A is present at the plasma membrane as part of the human B-cell receptor. Reason: The source studies human tonsillar B cells and lymphoma models. The accessible main methods explicitly include CD79A surface staining and knockout characterization; its abstract reports loss of surface IgM after CD79A deletion. This is direct human membrane-expression evidence, not an inference from a mouse phenotype. Only selected main-text sections were inspected beyond the abstract. Supporting Evidence: |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: CD79A is an integral plasma-membrane receptor subunit. Reason: The UniProt location mapping is consistent with its transmembrane topology, human BCR structure and human surface-expression experiments. It is interpreted in the context of receptor assembly rather than as a claim that every splice product reaches the surface normally. Supporting Evidence: file:human/CD79A/CD79A-uniprot.txt SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane CC protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1112666 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5690701 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5690702 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5690740 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9606151 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9691421 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-983696 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-983700 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-983703 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-983707 | ACCEPT | Summary: CD79A functions in the plasma-membrane B-cell receptor signaling complex. Reason: The cached Reactome event places the BCR or its associated signaling assembly at the membrane. Independent human structural and surface-expression evidence supports the location. Enzymatic activities in the event belong to the named kinases, phosphatase or phospholipase, not to CD79A merely because it is part of the same assembly. |
| GO:0007166 cell surface receptor signaling pathway | IEA GO_REF:0000002 | MODIFY | Summary: CD79A participates specifically in the B-cell receptor signaling pathway. Reason: The broad InterPro-derived cell-surface receptor pathway is biologically correct but can be refined to the BCR pathway. CD79A performs signal-transducing and receptor-assembly work in that complex; the refinement does not attribute antigen binding or phosphorylation chemistry to CD79A. Proposed replacements: B cell receptor signaling pathway |
| GO:0009897 external side of plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: The extracellular region of CD79A participates in the surface B-cell receptor complex. Reason: The extracellular immunoglobulin-like region of CD79A is exposed outside the plasma membrane and contacts membrane immunoglobulin in the receptor assembly. Its ITAM remains cytoplasmic. Human structural evidence supports the exposed domain's location and assembly contribution without assigning extracellular kinase docking or autonomous antigen recognition. The original phylogenetic/orthology assertion is retained; no independent reconstruction of its ancestral node is claimed. |
| GO:0009897 external side of plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: The extracellular region of CD79A participates in the surface B-cell receptor complex. Reason: The extracellular immunoglobulin-like region of CD79A is exposed outside the plasma membrane and contacts membrane immunoglobulin in the receptor assembly. Its ITAM remains cytoplasmic. Human structural evidence supports the exposed domain's location and assembly contribution without assigning extracellular kinase docking or autonomous antigen recognition. The original phylogenetic/orthology assertion is retained; no independent reconstruction of its ancestral node is claimed. |
| GO:0009897 external side of plasma membrane | ISS GO_REF:0000024 | ACCEPT | Summary: The extracellular region of CD79A participates in the surface B-cell receptor complex. Reason: The extracellular immunoglobulin-like region of CD79A is exposed outside the plasma membrane and contacts membrane immunoglobulin in the receptor assembly. Its ITAM remains cytoplasmic. Human structural evidence supports the exposed domain's location and assembly contribution without assigning extracellular kinase docking or autonomous antigen recognition. The original phylogenetic/orthology assertion is retained; no independent reconstruction of its ancestral node is claimed. |
| GO:0016020 membrane | IEA GO_REF:0000002 | MODIFY | Summary: Refine membrane localization to the established cell-surface receptor location. Reason: The single-pass CD79 chain is part of the plasma-membrane BCR; the more informative supported location is already represented in this review. Intracellular trafficking does not negate this refinement. Proposed replacements: plasma membrane |
| GO:0019815 B cell receptor complex | IBA GO_REF:0000033 | ACCEPT | Summary: CD79A is an integral signaling subunit of the B-cell receptor complex. Reason: The human IgM-BCR structure contains the Ig-alpha/Ig-beta heterodimer alongside immunoglobulin heavy and light chains. This direct human evidence corroborates the source phylogenetic and orthology assertions. Self-inclusion of human CD79A among PAINT descendant evidence is legitimate and is not considered circular. The shorter splice transcript is not assumed to form the same intact complex without functional evidence. |
| GO:0019815 B cell receptor complex | IDA PMID:35981043 Cryo-EM structure of the human IgM B cell receptor. | ACCEPT | Summary: CD79A is an integral signaling subunit of the B-cell receptor complex. Reason: The human IgM-BCR structure contains the Ig-alpha/Ig-beta heterodimer alongside immunoglobulin heavy and light chains. This direct human evidence corroborates the source phylogenetic and orthology assertions. Self-inclusion of human CD79A among PAINT descendant evidence is legitimate and is not considered circular. The shorter splice transcript is not assumed to form the same intact complex without functional evidence. |
| GO:0019815 B cell receptor complex | IEA GO_REF:0000107 | ACCEPT | Summary: CD79A is an integral signaling subunit of the B-cell receptor complex. Reason: The human IgM-BCR structure contains the Ig-alpha/Ig-beta heterodimer alongside immunoglobulin heavy and light chains. This direct human evidence corroborates the source phylogenetic and orthology assertions. Self-inclusion of human CD79A among PAINT descendant evidence is legitimate and is not considered circular. The shorter splice transcript is not assumed to form the same intact complex without functional evidence. |
| GO:0019815 B cell receptor complex | ISS GO_REF:0000024 | ACCEPT | Summary: CD79A is an integral signaling subunit of the B-cell receptor complex. Reason: The human IgM-BCR structure contains the Ig-alpha/Ig-beta heterodimer alongside immunoglobulin heavy and light chains. This direct human evidence corroborates the source phylogenetic and orthology assertions. Self-inclusion of human CD79A among PAINT descendant evidence is legitimate and is not considered circular. The shorter splice transcript is not assumed to form the same intact complex without functional evidence. |
| GO:0030183 B cell differentiation | IBA GO_REF:0000033 | ACCEPT | Summary: CD79A supports B-cell differentiation through pre-BCR/BCR assembly and signaling. Reason: The existing inherited function is corroborated by a human splice-defect study showing a block at the pro-B to pre-B transition. The full source distinguishes impaired surface-receptor assembly from a claim that CD79A catalyzes immunoglobulin rearrangement. Its molecular participation is supplied by the receptor subunit itself; no recombinase activity or new developmental process is inferred. |
| GO:0030183 B cell differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: CD79A supports B-cell differentiation through pre-BCR/BCR assembly and signaling. Reason: The existing inherited function is corroborated by a human splice-defect study showing a block at the pro-B to pre-B transition. The full source distinguishes impaired surface-receptor assembly from a claim that CD79A catalyzes immunoglobulin rearrangement. Its molecular participation is supplied by the receptor subunit itself; no recombinase activity or new developmental process is inferred. |
| GO:0030183 B cell differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: CD79A supports B-cell differentiation through pre-BCR/BCR assembly and signaling. Reason: The existing inherited function is corroborated by a human splice-defect study showing a block at the pro-B to pre-B transition. The full source distinguishes impaired surface-receptor assembly from a claim that CD79A catalyzes immunoglobulin rearrangement. Its molecular participation is supplied by the receptor subunit itself; no recombinase activity or new developmental process is inferred. |
| GO:0042100 B cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: CD79A contributes to B-cell proliferative responses through the BCR. Reason: The original mouse-derived functional assertion is consistent with the conserved BCR signaling unit and human receptor-dependent fitness studies. Proliferation and survival vary with cell state and lymphoma model. Retain proliferation as a supported downstream cellular outcome, while receptor assembly and signaling define the core activity. Human fitness measurements are not presented as direct proof of a universal division response. |
| GO:0042100 B cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: CD79A contributes to B-cell proliferative responses through the BCR. Reason: The original mouse-derived functional assertion is consistent with the conserved BCR signaling unit and human receptor-dependent fitness studies. Proliferation and survival vary with cell state and lymphoma model. Retain proliferation as a supported downstream cellular outcome, while receptor assembly and signaling define the core activity. Human fitness measurements are not presented as direct proof of a universal division response. |
| GO:0042113 B cell activation | IEA GO_REF:0000107 | ACCEPT | Summary: CD79A contributes to B-cell activation as part of the BCR signaling unit. Reason: The conserved ITAM-containing cytoplasmic region couples receptor engagement to recruitment of intracellular signaling proteins. Human receptor structure and surface-expression evidence support the complex context, and cytoplasmic-tail experiments establish signal-transduction capability. The original mouse transfer remains identified as such. |
| GO:0042113 B cell activation | ISS GO_REF:0000024 | ACCEPT | Summary: CD79A contributes to B-cell activation as part of the BCR signaling unit. Reason: The conserved ITAM-containing cytoplasmic region couples receptor engagement to recruitment of intracellular signaling proteins. Human receptor structure and surface-expression evidence support the complex context, and cytoplasmic-tail experiments establish signal-transduction capability. The original mouse transfer remains identified as such. |
| GO:0042802 identical protein binding | IDA PMID:14967045 Homooligomerization of the cytoplasmic domain of the T cell ... | KEEP AS NON CORE | Summary: The isolated Ig-alpha cytoplasmic domain can oligomerize in vitro. Reason: The original abstract explicitly includes B-cell receptor Ig-alpha among the purified ITAM-containing domains studied and reports dimers and tetramers. Its T-cell-receptor-focused title is not a reason to reject the CD79A annotation. This is retained as a biochemical property of the isolated domain, not as evidence that the physiological surface BCR uses a CD79A homodimer instead of the Ig-alpha/Ig-beta heterodimer. Supporting Evidence: PMID:14967045 Igalpha(cyt) forms stable dimers and tetramers even below 10 microM. |
| GO:0045121 membrane raft | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: CD79A-containing BCR can associate with membrane rafts in a stimulation-dependent context. Reason: The source transfers the location from the mouse ortholog. The reviewed UniProt record supports redistribution of BCR into raft fractions after engagement while also noting signaling outside rafts. Retain this conditional localization, without treating detergent-resistant fractionation as a unique constitutive site or claiming newly inspected human imaging evidence. Supporting Evidence: file:human/CD79A/CD79A-uniprot.txt Following antigen binding, the BCR has been shown to CC translocate from detergent-soluble regions of the cell membrane to CC lipid rafts although signal transduction through the complex can also CC occur outside lipid rafts. |
| GO:0045121 membrane raft | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: CD79A-containing BCR can associate with membrane rafts in a stimulation-dependent context. Reason: The source transfers the location from the mouse ortholog. The reviewed UniProt record supports redistribution of BCR into raft fractions after engagement while also noting signaling outside rafts. Retain this conditional localization, without treating detergent-resistant fractionation as a unique constitutive site or claiming newly inspected human imaging evidence. Supporting Evidence: file:human/CD79A/CD79A-uniprot.txt Following antigen binding, the BCR has been shown to CC translocate from detergent-soluble regions of the cell membrane to CC lipid rafts although signal transduction through the complex can also CC occur outside lipid rafts. |
| GO:0050853 B cell receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: CD79A supplies the signaling-subunit contribution to the B-cell receptor pathway. Reason: The ITAM-bearing receptor subunit recruits signaling machinery after phosphorylation and is required for normal receptor assembly and surface expression. The conserved pathway assertion agrees with human structural and functional evidence. Antigen recognition and catalytic phosphorylation remain assigned to immunoglobulin and kinases respectively; the PAINT node or full orthology chain was not independently rebuilt. |
| GO:0050853 B cell receptor signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: CD79A supplies the signaling-subunit contribution to the B-cell receptor pathway. Reason: The ITAM-bearing receptor subunit recruits signaling machinery after phosphorylation and is required for normal receptor assembly and surface expression. The conserved pathway assertion agrees with human structural and functional evidence. Antigen recognition and catalytic phosphorylation remain assigned to immunoglobulin and kinases respectively; the PAINT node or full orthology chain was not independently rebuilt. |
| GO:0071755 IgM B cell receptor complex | IDA PMID:35981043 Cryo-EM structure of the human IgM B cell receptor. | ACCEPT | Summary: CD79A is a component of the human IgM B-cell receptor complex. Reason: The source abstract directly reports a human IgM-BCR cryo-EM structure comprising two heavy chains, two light chains and the Ig-alpha/Ig-beta heterodimer. This directly supports the complex membership even though the complete original structural article was not accessible. Supporting Evidence: PMID:35981043 IgM-BCR comprises two heavy chains, two light chains, and the IgΞ±/IgΞ² heterodimer. |
| GO:0071755 IgM B cell receptor complex | IDA PMID:36949194 Immunoglobulin M perception by FcΞΌR. | ACCEPT | Summary: CD79A is a component of the IgM B-cell receptor complex. Reason: The Fc-mu-receptor study examines binding sites in the context of IgM BCR, but the accessible abstract does not enumerate every modeled BCR subunit and the complete target-level structural analysis was not inspected. Independent human IgM-BCR structural evidence directly establishes CD79A membership, so the original curator assignment is retained without alleging misattribution from the paper's Fc-mu-receptor focus. |
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Download this section (compressed HTML)Q: Which physiological B-cell interactions among the screen-supported partners can be reproduced with endogenous CD79A in the correct membrane and signaling context?
Q: Does the shorter CD79A splice product form a stable protein and assemble with CD79B and immunoglobulin, and how does its signaling differ from the full-length subunit?
Experiment: Compare the long and short CD79A products at matched expression in a CD79A-deficient human B-cell system, measuring CD79B association, immunoglobulin surface expression and receptor-induced signaling; establish protein expression before interpreting absence of function.
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