CDK7 is the catalytic kinase subunit of the cyclin-H/MAT1 CDK-activating kinase complex. It activates cell-cycle CDKs and, as a TFIIH-associated kinase, phosphorylates the RNA polymerase II C-terminal domain to regulate transcription.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000307 cyclin-dependent protein kinase holoenzyme complex | IDA PMID:23622515 A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progr... | UNDECIDED | Summary: CDK7 forms the cyclin-H/MAT1 CDK-activating kinase assembly. The target-specific support in PMID:23622515 still requires detailed assessment of the experimental results. Reason: CDK7 forms the cyclin-H/MAT1 CDK-activating kinase assembly. The target-specific support in PMID:23622515 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0000439 transcription factor TFIIH core complex | IDA PMID:8692841 Isolation and characterization of two human transcription fa... | MODIFY | Summary: QuickGO defines the seven-subunit TFIIH core without CDK7. CDK7 belongs to the CAK module of holo-TFIIH, not the seven-subunit core. Reason: QuickGO defines the seven-subunit TFIIH core without CDK7. CDK7 belongs to the CAK module of holo-TFIIH, not the seven-subunit core. Proposed replacements: transcription factor TFIIH holo complex Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0001650 fibrillar center | IDA GO_REF:0000052 | UNDECIDED | Summary: The specific fibrillar-center localization is not established by the catalytic-domain comparison or the accessible CDK7 structural study. Reason: The specific fibrillar-center localization is not established by the catalytic-domain comparison or the accessible CDK7 structural study. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: The conserved kinase is a cyclin-dependent serine/threonine kinase; the broad protein kinase term can be made specific. Reason: The conserved kinase is a cyclin-dependent serine/threonine kinase; the broad protein kinase term can be made specific. Proposed replacements: cyclin-dependent protein serine/threonine kinase activity Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004672 protein kinase activity | TAS PMID:7533895 Cdk-activating kinase complex is a component of human transc... | MODIFY | Summary: The conserved kinase is a cyclin-dependent serine/threonine kinase; the broad protein kinase term can be made specific. Reason: The conserved kinase is a cyclin-dependent serine/threonine kinase; the broad protein kinase term can be made specific. Proposed replacements: cyclin-dependent protein serine/threonine kinase activity Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000107 | MODIFY | Summary: Cyclin dependence is a conserved characteristic of CDK7. Reason: Cyclin dependence is a conserved characteristic of CDK7. Proposed replacements: cyclin-dependent protein serine/threonine kinase activity Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-6810233 | MODIFY | Summary: Cyclin dependence is a conserved characteristic of CDK7. Reason: Cyclin dependence is a conserved characteristic of CDK7. Proposed replacements: cyclin-dependent protein serine/threonine kinase activity Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-77071 | MODIFY | Summary: Cyclin dependence is a conserved characteristic of CDK7. Reason: Cyclin dependence is a conserved characteristic of CDK7. Proposed replacements: cyclin-dependent protein serine/threonine kinase activity Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004693 cyclin-dependent protein serine/threonine kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: Human CDK7 structural and biochemical studies establish cyclin-dependent phosphorylation of protein substrates. Reason: Human CDK7 structural and biochemical studies establish cyclin-dependent phosphorylation of protein substrates. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004693 cyclin-dependent protein serine/threonine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: Human CDK7 structural and biochemical studies establish cyclin-dependent phosphorylation of protein substrates. Reason: Human CDK7 structural and biochemical studies establish cyclin-dependent phosphorylation of protein substrates. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0004693 cyclin-dependent protein serine/threonine kinase activity | TAS PMID:8208544 Two novel human serine/threonine kinases with homologies to ... | ACCEPT | Summary: Human CDK7 structural and biochemical studies establish cyclin-dependent phosphorylation of protein substrates. Reason: Human CDK7 structural and biochemical studies establish cyclin-dependent phosphorylation of protein substrates. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:10801852 Distinct regions of MAT1 regulate cdk7 kinase and TFIIH tran... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:10958787 Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 his... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:15530371 The crystal structure of human CDK7 and its protein recognit... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:16327805 Dichotomous but stringent substrate selection by the dual-fu... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:16327805 Dichotomous but stringent substrate selection by the dual-fu... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:16327805 Dichotomous but stringent substrate selection by the dual-fu... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:22939624 Quantitative analysis of HSP90-client interactions reveals p... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:23393140 Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CD... | UNDECIDED | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. The target-specific support in PMID:23393140 still requires detailed assessment of the experimental results. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. The target-specific support in PMID:23393140 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:23455922 Interlaboratory reproducibility of large-scale human protein... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:23602568 The protein interaction landscape of the human CMGC kinase g... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:23602568 The protein interaction landscape of the human CMGC kinase g... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | KEEP AS NON CORE | Summary: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Reason: The reported interaction is retained as a physical association; generic protein binding does not specify the CDK7 kinase mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: The human ATP-bound crystal structure directly establishes ATP binding by CDK7. Reason: The human ATP-bound crystal structure directly establishes ATP binding by CDK7. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005634 nucleus | EXP PMID:15695176 Cyclin-dependent kinase activating kinase/Cdk7 co-localizes ... | ACCEPT | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005634 nucleus | EXP PMID:19071173 DNA-Bound peptides control the mRNA transcription through CD... | UNDECIDED | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. The target-specific support in PMID:19071173 still requires detailed assessment of the experimental results. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. The target-specific support in PMID:19071173 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005634 nucleus | IDA PMID:10958787 Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 his... | ACCEPT | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005634 nucleus | IDA PMID:16109376 The bromodomain protein Brd4 is a positive regulatory compon... | ACCEPT | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005634 nucleus | TAS PMID:7936635 Cloning, expression and subcellular localization of the huma... | ACCEPT | Summary: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Reason: Nuclear transcriptional and cell-cycle functions are characteristic of CDK7 and its conserved CAK/TFIIH associations. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | IEA GO_REF:0000107 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-109639 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-111264 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-112379 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-112383 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-112385 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-113430 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-170076 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-170087 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-187949 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-188350 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5689861 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5691000 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6781818 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6781824 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6781833 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6781840 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6781867 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782004 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782069 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782131 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782138 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782141 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782204 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782208 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782211 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782224 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782227 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6782234 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6797606 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6797616 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6810233 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6810234 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6810235 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6810238 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6814549 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6814555 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6814559 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-6814885 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-73758 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-73769 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-73946 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-74986 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-74992 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-74993 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-74994 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75850 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75856 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75861 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75862 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75864 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75866 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75869 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75873 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75891 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-75949 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-76576 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77068 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77069 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77071 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77073 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77077 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77078 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77081 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77083 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77085 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-77090 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8942836 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9613494 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9613497 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9684118 | ACCEPT | Summary: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Reason: Nucleoplasmic activity is consistent with the conserved transcription-associated CDK7 complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005675 transcription factor TFIIH holo complex | IDA PMID:9852112 Immunoaffinity purification and functional characterization ... | ACCEPT | Summary: CDK7 is the kinase subunit of the CAK module associated with TFIIH holo complex. Reason: CDK7 is the kinase subunit of the CAK module associated with TFIIH holo complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005675 transcription factor TFIIH holo complex | IEA GO_REF:0000002 | ACCEPT | Summary: CDK7 is the kinase subunit of the CAK module associated with TFIIH holo complex. Reason: CDK7 is the kinase subunit of the CAK module associated with TFIIH holo complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005675 transcription factor TFIIH holo complex | IPI PMID:15220921 A new, tenth subunit of TFIIH is responsible for the DNA rep... | ACCEPT | Summary: CDK7 is the kinase subunit of the CAK module associated with TFIIH holo complex. Reason: CDK7 is the kinase subunit of the CAK module associated with TFIIH holo complex. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0005737 cytoplasm | EXP PMID:15695176 Cyclin-dependent kinase activating kinase/Cdk7 co-localizes ... | KEEP AS NON CORE | Summary: A cytoplasmic CDK7 pool is compatible with cell-cycle regulation, but transcription-associated nuclear kinase activity is the dominant functional interpretation. Reason: A cytoplasmic CDK7 pool is compatible with cell-cycle regulation, but transcription-associated nuclear kinase activity is the dominant functional interpretation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: A cytoplasmic CDK7 pool is compatible with cell-cycle regulation, but transcription-associated nuclear kinase activity is the dominant functional interpretation. Reason: A cytoplasmic CDK7 pool is compatible with cell-cycle regulation, but transcription-associated nuclear kinase activity is the dominant functional interpretation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: A cytoplasmic CDK7 pool is compatible with cell-cycle regulation, but transcription-associated nuclear kinase activity is the dominant functional interpretation. Reason: A cytoplasmic CDK7 pool is compatible with cell-cycle regulation, but transcription-associated nuclear kinase activity is the dominant functional interpretation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: A cytosolic CDK7 pool is compatible with the cellular distribution reported for human CDK7, but does not define its primary transcriptional role. Reason: A cytosolic CDK7 pool is compatible with the cellular distribution reported for human CDK7, but does not define its primary transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0006289 nucleotide-excision repair | NAS PMID:22572993 TFIIH: when transcription met DNA repair. | KEEP AS NON CORE | Summary: TFIIH participates in nucleotide-excision repair, but CDK7 is the kinase in the associated CAK module rather than a DNA-unwinding enzyme. The process-level association is retained without transferring another subunit activity. Reason: TFIIH participates in nucleotide-excision repair, but CDK7 is the kinase in the associated CAK module rather than a DNA-unwinding enzyme. The process-level association is retained without transferring another subunit activity. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006366 transcription by RNA polymerase II | TAS Reactome:R-HSA-73857 | ACCEPT | Summary: Phosphorylation of RNA polymerase II CTD is a central contribution to transcription. Reason: Phosphorylation of RNA polymerase II CTD is a central contribution to transcription. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006367 transcription initiation at RNA polymerase II promoter | IBA GO_REF:0000033 | ACCEPT | Summary: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Reason: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006367 transcription initiation at RNA polymerase II promoter | IDA PMID:26257281 THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping an... | ACCEPT | Summary: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Reason: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006367 transcription initiation at RNA polymerase II promoter | IDA PMID:7533895 Cdk-activating kinase complex is a component of human transc... | ACCEPT | Summary: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Reason: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006367 transcription initiation at RNA polymerase II promoter | IDA PMID:8692841 Isolation and characterization of two human transcription fa... | ACCEPT | Summary: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Reason: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006367 transcription initiation at RNA polymerase II promoter | NAS PMID:22572993 TFIIH: when transcription met DNA repair. | ACCEPT | Summary: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Reason: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0006367 transcription initiation at RNA polymerase II promoter | TAS PMID:7533895 Cdk-activating kinase complex is a component of human transc... | ACCEPT | Summary: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Reason: CDK7 phosphorylation of RNA polymerase II CTD promotes transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008094 ATP-dependent activity, acting on DNA | IDA PMID:9852112 Immunoaffinity purification and functional characterization ... | UNDECIDED | Summary: QuickGO defines ATP-driven modification of DNA, whereas CDK7 is a protein kinase. The cited purification study examines whole TFIIH; its full assay context must be checked before rejecting this experimental subunit assignment. Reason: QuickGO defines ATP-driven modification of DNA, whereas CDK7 is a protein kinase. The cited purification study examines whole TFIIH; its full assay context must be checked before rejecting this experimental subunit assignment. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity | EXP PMID:26257281 THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping an... | ACCEPT | Summary: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Reason: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity | EXP PMID:28768201 Human TFIIH Kinase CDK7 Regulates Transcription-Associated C... | ACCEPT | Summary: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Reason: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Reason: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity | IDA PMID:12721286 A novel RNA polymerase II C-terminal domain phosphatase that... | ACCEPT | Summary: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Reason: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity | IDA PMID:9852112 Immunoaffinity purification and functional characterization ... | ACCEPT | Summary: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Reason: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Reason: CDK7 phosphorylates the RNA polymerase II CTD in its conserved transcriptional role. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0016301 kinase activity | IEA GO_REF:0000107 | MODIFY | Summary: The retained CDK7 catalytic domain supports the more informative cyclin-dependent protein kinase term. Reason: The retained CDK7 catalytic domain supports the more informative cyclin-dependent protein kinase term. Proposed replacements: cyclin-dependent protein serine/threonine kinase activity Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0042795 snRNA transcription by RNA polymerase II | TAS Reactome:R-HSA-6807505 | ACCEPT | Summary: CDK7 supports RNA polymerase II transcription, including the polymerase-II-transcribed small nuclear RNA program represented by the pathway annotation. Reason: CDK7 supports RNA polymerase II transcription, including the polymerase-II-transcribed small nuclear RNA program represented by the pathway annotation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:9852112 Immunoaffinity purification and functional characterization ... | ACCEPT | Summary: CTD phosphorylation promotes RNA polymerase II transcription; this is central to the CDK7 mechanism. Reason: CTD phosphorylation promotes RNA polymerase II transcription; this is central to the CDK7 mechanism. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Perinuclear localization is a secondary cellular pool and does not define the catalytic function. Reason: Perinuclear localization is a secondary cellular pool and does not define the catalytic function. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958787, CC ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm CC {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region CC {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the CC cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus CC to cytoplasm and perinuclear region in response to DNA-bound peptides CC (PubMed:19071173). {ECO:0000269|PubMed:15695176, CC ECO:0000269|PubMed:19071173}. |
| GO:0050821 protein stabilization | IMP PMID:23393140 Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CD... | UNDECIDED | Summary: Protein stabilization is substrate- and context-dependent; conserved kinase activity alone does not identify the relevant stabilization mechanism. The target-specific support in PMID:23393140 still requires detailed assessment of the experimental results. Reason: Protein stabilization is substrate- and context-dependent; conserved kinase activity alone does not identify the relevant stabilization mechanism. The target-specific support in PMID:23393140 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0051726 regulation of cell cycle | IBA GO_REF:0000033 | ACCEPT | Summary: CDK7 activates cell-cycle CDKs by phosphorylation of their activation segments. Reason: CDK7 activates cell-cycle CDKs by phosphorylation of their activation segments. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0051726 regulation of cell cycle | TAS PMID:15876871 CAK-Cyclin-dependent Activating Kinase: a key kinase in cell... | UNDECIDED | Summary: CDK7 activates cell-cycle CDKs by phosphorylation of their activation segments. The target-specific support in PMID:15876871 still requires detailed assessment of the experimental results. Reason: CDK7 activates cell-cycle CDKs by phosphorylation of their activation segments. The target-specific support in PMID:15876871 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0070516 CAK-ERCC2 complex | IDA PMID:8692841 Isolation and characterization of two human transcription fa... | ACCEPT | Summary: CDK7 is part of the conserved CAK module that associates with ERCC2/XPD. Reason: CDK7 is part of the conserved CAK module that associates with ERCC2/XPD. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0070985 transcription factor TFIIK complex | IBA GO_REF:0000033 | ACCEPT | Summary: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. Reason: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0070985 transcription factor TFIIK complex | IDA PMID:8692841 Isolation and characterization of two human transcription fa... | ACCEPT | Summary: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. Reason: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0070985 transcription factor TFIIK complex | IEA GO_REF:0000002 | ACCEPT | Summary: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. Reason: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0070985 transcription factor TFIIK complex | IMP PMID:23393140 Interaction with cyclin H/cyclin-dependent kinase 7 (CCNH/CD... | UNDECIDED | Summary: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. The target-specific support in PMID:23393140 still requires detailed assessment of the experimental results. Reason: The TFIIK/CAK kinase module contains CDK7, cyclin H and MAT1. The target-specific support in PMID:23393140 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0106310 protein serine kinase activity | EXP PMID:20360007 Cdc25 phosphatases are required for timely assembly of CDK1-... | ACCEPT | Summary: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Reason: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0106310 protein serine kinase activity | EXP PMID:9372954 p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependen... | ACCEPT | Summary: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Reason: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0106310 protein serine kinase activity | EXP PMID:9840937 Regulation of CAK kinase activity by p53. | ACCEPT | Summary: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Reason: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000116 | ACCEPT | Summary: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Reason: Serine phosphorylation of protein substrates, including the polymerase II CTD, is a direct CDK7 reaction. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:0140836 RNA polymerase II CTD heptapeptide repeat S5 kinase activity | IDA PMID:26257281 THZ1 Reveals Roles for Cdk7 in Co-transcriptional Capping an... | ACCEPT | Summary: Human CDK7 phosphorylates Ser5 in the RNA polymerase II C-terminal domain during transcription initiation. Reason: Human CDK7 phosphorylates Ser5 in the RNA polymerase II C-terminal domain during transcription initiation. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
| GO:2000045 regulation of G1/S transition of mitotic cell cycle | IDA PMID:23622515 A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progr... | UNDECIDED | Summary: CDK activation by CDK7 links its kinase activity to G1/S cell-cycle control. The target-specific support in PMID:23622515 still requires detailed assessment of the experimental results. Reason: CDK activation by CDK7 links its kinase activity to G1/S cell-cycle control. The target-specific support in PMID:23622515 still requires detailed assessment of the experimental results. Supporting Evidence: file:human/CDK7/CDK7-uniprot.txt CC -!- FUNCTION: Serine/threonine kinase involved in cell cycle control and in CC RNA polymerase II-mediated RNA transcription (PubMed:9852112, CC PubMed:19136461, PubMed:26257281, PubMed:28768201). As a cyclin- CC dependent kinase, CDK7 is activated by the binding to cyclin-H/CCNH and CC the CDK-activating kinase assembly factor MAT1 (PubMed:41100585). CC Catalytic subunit of the CDK-activating kinase (CAK) complex, a master CC regulator of CDK activity by catalyzing the activating threonine CC phosphorylation of CDKs (PubMed:41100585). CAK activates major CC mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, CC and plays a key role in regulating cell cycle progression CC (PubMed:41100585). CAK complexed to the core-TFIIH basal transcription CC factor activates RNA polymerase II by serine phosphorylation of the CTD CC of POLR2A, allowing its escape from the promoter and elongation of the CC transcripts (PubMed:9852112). Initiates transcription by RNA polymerase CC II by mediating phosphorylation of POLR2A at 'Ser-5' of the repetitive CC C-terminal domain (CTD) when POLR2A is in complex with DNA, promoting CC dissociation from DNA and initiation (PubMed:19136461, PubMed:26257281, CC PubMed:28768201). Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, CC p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11 (PubMed:9372954, CC PubMed:9840937, PubMed:19136461, PubMed:26257281, PubMed:28768201, CC PubMed:41100585, PubMed:41100585). Its expression and activity are CC constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 CC activation by phosphorylation, but is inactivated in turn by p53/TP53; CC this feedback loop may lead to an arrest of the cell cycle and of the CC transcription, helping in cell recovery, or to apoptosis. Required for CC DNA-bound peptides-mediated transcription and cellular growth CC inhibition. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11113184, CC ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, CC ECO:0000269|PubMed:17386261, ECO:0000269|PubMed:17901130, CC ECO:0000269|PubMed:19015234, ECO:0000269|PubMed:19071173, CC ECO:0000269|PubMed:19136461, ECO:0000269|PubMed:19450536, CC ECO:0000269|PubMed:19667075, ECO:0000269|PubMed:20360007, CC ECO:0000269|PubMed:26257281, ECO:0000269|PubMed:28768201, CC ECO:0000269|PubMed:41100585, ECO:0000269|PubMed:9372954, CC ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}. |
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Download this section (compressed HTML)The human reference supplies mechanistic evidence for the corresponding selected horse protein; the human conclusion alone is not validation of the horse sequence. The exact horse comparison is in genes/HORSE/CDK7/CDK7-bioinformatics/RESULTS.md. Research reports are source leads; annotation decisions cite the underlying publication or experimentally supported UniProt passages. Unresolved source-specific results retain UNDECIDED.
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