{
  "schema_version": 1,
  "gene": "CFAP418",
  "accession": "Q96NL8",
  "audit_date": "2026-10-10",
  "kind": "Manual scientific assessment plus literal machine-field extraction; not a provider output",
  "source_main": "8a69f3d2b551d632a37bfeb6217a7d667db8d51b",
  "source_projection": {
    "original_machine_count": 8,
    "original_authored_NEW_count": 4,
    "current_normal_machine_count": 13,
    "decision": "Original eight source objects remain exact; new normal projection is retained separately as context.",
    "original_yaml_sha256": "0af2dc9539d7f695436ef50b64621b2643cae22095a117f628300914944efb3e",
    "fresh_normal_yaml_sha256": "eef61485e2941491abfd10458cb12d9a42b5f8c7671b909059a99e738bba2c39"
  },
  "interactions": {
    "receipt": {
      "url": "https://www.ebi.ac.uk/Tools/webservices/psicquic/intact/webservices/current/search/query/id:Q96NL8?format=tab27",
      "final_url": "https://www.ebi.ac.uk/Tools/webservices/psicquic/intact/webservices/current/search/query/id:Q96NL8?format=tab27",
      "status": 200,
      "bytes": 31223,
      "sha256": "5e932a41ab5ebe0635a2f809a1ccccc5791d3124d1186431cbdbcbe1e9f54b5e",
      "retrieved_at": "2026-10-10T08:12:12.730849+00:00"
    },
    "records": [
      {
        "raw_line_1based": 4,
        "raw_line_sha256": "d3a72dbc62bf99bca20f90182156d81ba1a0f86594cf6ba9a584f188ebf2bfa1",
        "participant_a": "uniprotkb:Q96NL8",
        "participant_b": "uniprotkb:P04632",
        "detection_method": "psi-mi:\"MI:0676\"(tandem affinity purification)",
        "publication": "pubmed:27173435|imex:IM-25054",
        "taxon_a": "taxid:9606(human)|taxid:9606(Homo sapiens)",
        "taxon_b": "taxid:9606(human)|taxid:9606(Homo sapiens)",
        "interaction_type": "psi-mi:\"MI:0915\"(physical association)",
        "interaction_accessions": "intact:EBI-12449224|imex:IM-25054-19",
        "experimental_role_a": "psi-mi:\"MI:0496\"(bait)",
        "experimental_role_b": "psi-mi:\"MI:0498\"(prey)",
        "host": "taxid:9606(human-293t)|taxid:9606(Homo sapiens HEK293T embryonic kidney cell)",
        "negative": "false",
        "feature_a": "tandem tag:c-c",
        "feature_b": "-"
      },
      {
        "raw_line_1based": 5,
        "raw_line_sha256": "f3fd2cfd0b2b2dc945bb60f37028354d9f40743c6b53eb132140ece272fa818a",
        "participant_a": "uniprotkb:Q96NL8",
        "participant_b": "uniprotkb:P04632",
        "detection_method": "psi-mi:\"MI:0676\"(tandem affinity purification)",
        "publication": "pubmed:27173435|imex:IM-25054",
        "taxon_a": "taxid:9606(human)|taxid:9606(Homo sapiens)",
        "taxon_b": "taxid:9606(human)|taxid:9606(Homo sapiens)",
        "interaction_type": "psi-mi:\"MI:0915\"(physical association)",
        "interaction_accessions": "intact:EBI-12449215|imex:IM-25054-18",
        "experimental_role_a": "psi-mi:\"MI:0496\"(bait)",
        "experimental_role_b": "psi-mi:\"MI:0498\"(prey)",
        "host": "taxid:9606(human-293t)|taxid:9606(Homo sapiens HEK293T embryonic kidney cell)",
        "negative": "false",
        "feature_a": "tandem tag:n-n",
        "feature_b": "-"
      }
    ],
    "scope": "The two curated records are two tag orientations in one study, not independent-study replication. Exact source target pair only; assay supports association without binary mechanism."
  },
  "ortholog_donor": {
    "receipt": {
      "url": "https://www.ebi.ac.uk/QuickGO/services/annotation/search?geneProductId=UniProtKB:Q3UJP5&limit=200",
      "final_url": "https://www.ebi.ac.uk/QuickGO/services/annotation/search?geneProductId=UniProtKB:Q3UJP5&limit=200",
      "status": 200,
      "bytes": 6386,
      "sha256": "b29195636c88d28ba9496c95218152c9e3c8cebc90a2a8bb8f03b93cb6737802",
      "retrieved_at": "2026-10-10T08:12:11.556552+00:00"
    },
    "total_hits": 13,
    "records": [
      {
        "id": "UniProtKB:Q3UJP5!447256260",
        "geneProductId": "UniProtKB:Q3UJP5",
        "qualifier": "involved_in",
        "goId": "GO:0008594",
        "goName": null,
        "goEvidence": "IMP",
        "goAspect": "biological_process",
        "evidenceCode": "ECO:0000315",
        "reference": "PMID:29440555",
        "withFrom": null,
        "taxonId": 10090,
        "taxonName": null,
        "assignedBy": "UniProt",
        "extensions": null,
        "targetSets": null,
        "symbol": "Cfap418",
        "date": "20180315",
        "synonyms": null,
        "name": null
      },
      {
        "id": "UniProtKB:Q3UJP5!447256264",
        "geneProductId": "UniProtKB:Q3UJP5",
        "qualifier": "located_in",
        "goId": "GO:0001917",
        "goName": null,
        "goEvidence": "IDA",
        "goAspect": "cellular_component",
        "evidenceCode": "ECO:0000314",
        "reference": "PMID:29440555",
        "withFrom": null,
        "taxonId": 10090,
        "taxonName": null,
        "assignedBy": "UniProt",
        "extensions": null,
        "targetSets": null,
        "symbol": "Cfap418",
        "date": "20180315",
        "synonyms": null,
        "name": null
      },
      {
        "id": "UniProtKB:Q3UJP5!447256268",
        "geneProductId": "UniProtKB:Q3UJP5",
        "qualifier": "located_in",
        "goId": "GO:0005737",
        "goName": null,
        "goEvidence": "IDA",
        "goAspect": "cellular_component",
        "evidenceCode": "ECO:0000314",
        "reference": "PMID:29440555",
        "withFrom": null,
        "taxonId": 10090,
        "taxonName": null,
        "assignedBy": "UniProt",
        "extensions": null,
        "targetSets": null,
        "symbol": "Cfap418",
        "date": "20180316",
        "synonyms": null,
        "name": null
      }
    ]
  },
  "ontology": [
    {
      "raw_response_sha256": "4d90b0deb7939341c64e9ea693ee066578355947d76d896a21a661db834de26e",
      "receipt": {
        "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0008594",
        "final_url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0008594",
        "status": 200,
        "bytes": 656,
        "sha256": "4d90b0deb7939341c64e9ea693ee066578355947d76d896a21a661db834de26e",
        "retrieved_at": "2026-10-10T08:12:14.916562+00:00"
      },
      "terms": [
        {
          "id": "GO:0008594",
          "isObsolete": false,
          "name": "photoreceptor cell morphogenesis",
          "definition": {
            "text": "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster."
          },
          "synonyms": [
            {
              "name": "photoreceptor development",
              "type": "related"
            }
          ],
          "children": [
            {
              "id": "GO:0061541",
              "relation": "part_of"
            }
          ],
          "aspect": "biological_process",
          "usage": "Unrestricted"
        }
      ]
    },
    {
      "raw_response_sha256": "045f18c402276e003805aefe57b1e501877c45e8eb413e3c930d1c2e458bc36a",
      "receipt": {
        "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0035845",
        "final_url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0035845",
        "status": 200,
        "bytes": 766,
        "sha256": "045f18c402276e003805aefe57b1e501877c45e8eb413e3c930d1c2e458bc36a",
        "retrieved_at": "2026-10-10T08:12:16.284773+00:00"
      },
      "terms": [
        {
          "id": "GO:0035845",
          "isObsolete": false,
          "name": "photoreceptor cell outer segment organization",
          "definition": {
            "text": "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.",
            "xrefs": [
              {
                "dbCode": "ISBN",
                "dbId": "0824072820"
              },
              {
                "dbCode": "PMID",
                "dbId": "14507858"
              }
            ]
          },
          "synonyms": [
            {
              "name": "photoreceptor cell outer segment organisation",
              "type": "exact"
            },
            {
              "name": "photoreceptor outer segment organization",
              "type": "exact"
            }
          ],
          "aspect": "biological_process",
          "usage": "Unrestricted"
        }
      ]
    },
    {
      "raw_response_sha256": "ff5a137b195b5d4cadcb9f97e9d4f2767adf8c8d0f2e9735af61ca57bf367aeb",
      "receipt": {
        "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0042073",
        "final_url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0042073",
        "status": 200,
        "bytes": 927,
        "sha256": "ff5a137b195b5d4cadcb9f97e9d4f2767adf8c8d0f2e9735af61ca57bf367aeb",
        "retrieved_at": "2026-10-10T08:12:16.040883+00:00"
      },
      "terms": [
        {
          "id": "GO:0042073",
          "isObsolete": false,
          "name": "intraciliary transport",
          "definition": {
            "text": "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.",
            "xrefs": [
              {
                "dbCode": "PMID",
                "dbId": "17981739"
              },
              {
                "dbCode": "PMID",
                "dbId": "18180368"
              },
              {
                "dbCode": "PMID",
                "dbId": "22869374"
              }
            ]
          },
          "comment": "Note that we deem cilium and microtubule-based flagellum to be equivalent.",
          "synonyms": [
            {
              "name": "IFT",
              "type": "related"
            },
            {
              "name": "intraflagellar transport",
              "type": "exact"
            },
            {
              "name": "intraflagellar transport involved in cilium organization",
              "type": "exact"
            },
            {
              "name": "intraflagellar transport involved in microtubule-based flagellum organisation",
              "type": "exact"
            }
          ],
          "children": [
            {
              "id": "GO:0035721",
              "relation": "is_a"
            },
            {
              "id": "GO:0035720",
              "relation": "is_a"
            },
            {
              "id": "GO:0035735",
              "relation": "is_a"
            }
          ],
          "aspect": "biological_process",
          "usage": "Unrestricted"
        }
      ]
    },
    {
      "raw_response_sha256": "fc71177dd2ba09d66669e97cb438f95a9fccb21df7d60f3464499e2f4d1dad71",
      "receipt": {
        "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0097110",
        "final_url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0097110",
        "status": 200,
        "bytes": 554,
        "sha256": "fc71177dd2ba09d66669e97cb438f95a9fccb21df7d60f3464499e2f4d1dad71",
        "retrieved_at": "2026-10-10T08:12:16.728743+00:00"
      },
      "terms": [
        {
          "id": "GO:0097110",
          "isObsolete": false,
          "name": "scaffold protein binding",
          "definition": {
            "text": "Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.",
            "xrefs": [
              {
                "dbCode": "PMID",
                "dbId": "10433269"
              },
              {
                "dbCode": "Wikipedia",
                "dbId": "Scaffold_protein"
              }
            ]
          },
          "aspect": "molecular_function",
          "usage": "Unrestricted"
        }
      ]
    },
    {
      "raw_response_sha256": "ffa7f20666094fab6e1a09254140a21c4189174f456c8bbe3f4007ce86951a80",
      "receipt": {
        "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0070300,GO:1901612,GO:0008289,GO:0005543",
        "final_url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0070300,GO:1901612,GO:0008289,GO:0005543",
        "status": 200,
        "content_type": "application/json",
        "bytes": 2078,
        "sha256": "ffa7f20666094fab6e1a09254140a21c4189174f456c8bbe3f4007ce86951a80",
        "retrieved_at": "2026-10-10T08:16:16.941177+00:00"
      },
      "terms": [
        {
          "id": "GO:0005543",
          "isObsolete": false,
          "name": "phospholipid binding",
          "definition": {
            "text": "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.",
            "xrefs": [
              {
                "dbCode": "ISBN",
                "dbId": "0198506732"
              }
            ]
          },
          "children": [
            {
              "id": "GO:0005545",
              "relation": "is_a"
            },
            {
              "id": "GO:0005544",
              "relation": "is_a"
            },
            {
              "id": "GO:0008429",
              "relation": "is_a"
            },
            {
              "id": "GO:1901611",
              "relation": "is_a"
            },
            {
              "id": "GO:0035727",
              "relation": "is_a"
            },
            {
              "id": "GO:0031210",
              "relation": "is_a"
            },
            {
              "id": "GO:0034235",
              "relation": "is_a"
            },
            {
              "id": "GO:0070300",
              "relation": "is_a"
            },
            {
              "id": "GO:0001786",
              "relation": "is_a"
            },
            {
              "id": "GO:1902387",
              "relation": "is_a"
            },
            {
              "id": "GO:1901981",
              "relation": "is_a"
            }
          ],
          "aspect": "molecular_function",
          "usage": "Unrestricted"
        },
        {
          "id": "GO:0070300",
          "isObsolete": false,
          "name": "phosphatidic acid binding",
          "definition": {
            "text": "Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.",
            "xrefs": [
              {
                "dbCode": "CHEBI",
                "dbId": "16337"
              },
              {
                "dbCode": "ISBN",
                "dbId": "0198506732"
              }
            ]
          },
          "synonyms": [
            {
              "name": "phosphatidate binding",
              "type": "exact"
            }
          ],
          "aspect": "molecular_function",
          "usage": "Unrestricted"
        },
        {
          "id": "GO:0008289",
          "isObsolete": false,
          "name": "lipid binding",
          "definition": {
            "text": "Binding to a lipid."
          },
          "children": [
            {
              "id": "GO:0019992",
              "relation": "is_a"
            },
            {
              "id": "GO:0005504",
              "relation": "is_a"
            },
            {
              "id": "GO:1900131",
              "relation": "negatively_regulates"
            },
            {
              "id": "GO:0017129",
              "relation": "is_a"
            },
            {
              "id": "GO:1901567",
              "relation": "is_a"
            },
            {
              "id": "GO:0005496",
              "relation": "is_a"
            },
            {
              "id": "GO:0001530",
              "relation": "is_a"
            },
            {
              "id": "GO:0030882",
              "relation": "is_a"
            },
            {
              "id": "GO:0005543",
              "relation": "is_a"
            },
            {
              "id": "GO:0051861",
              "relation": "is_a"
            },
            {
              "id": "GO:0019840",
              "relation": "is_a"
            },
            {
              "id": "GO:0046625",
              "relation": "is_a"
            },
            {
              "id": "GO:0071723",
              "relation": "is_a"
            }
          ],
          "aspect": "molecular_function",
          "usage": "Unrestricted"
        },
        {
          "id": "GO:1901612",
          "isObsolete": false,
          "name": "cardiolipin binding",
          "definition": {
            "text": "Binding to cardiolipin."
          },
          "aspect": "molecular_function",
          "usage": "Unrestricted"
        }
      ]
    }
  ],
  "lipid_inference": {
    "primary": "PMID:37971880",
    "human": "UniProtKB:Q96NL8",
    "tested_mouse": "UniProtKB:Q3UJP5",
    "construct": "Full-length mouse NM_026005-derived His and GST proteins, bacterial expression and retained tags.",
    "assay": "Immobilized lipid/PIP-strip overlay at 1 microgram/mL, with detection-positive protein spot and other lipids/blank comparisons. No isolated-tag control is claimed.",
    "findings": "Both tags bind PA and cardiolipin; weaker His-only LPA is not proposed as an additional function.",
    "evidence_type_for_human": "ISS",
    "direct_human_validation": false,
    "one_core": "GO:0005543",
    "specific_proposals": [
      "GO:0070300",
      "GO:1901612"
    ],
    "no_new_process": true,
    "peer_report_sha256": "8fdbb2af605cd949796c7c06d52f58ab53bebae0c694f6a6aec6e4ec0731c6b1",
    "peer_ontology_ancestors": [
      {
        "receipt": {
          "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:0070300/ancestors?relations=is_a",
          "status": 200,
          "sha256": "339461d89dc707e593d8096bb4f6e700d5c1c0e79f1e3b46a7f63a56c3b5700e",
          "bytes": 625,
          "retrieved_at": "2026-10-10T08:18:58.141177+00:00"
        },
        "response": {
          "numberOfHits": 1,
          "results": [
            {
              "id": "GO:0070300",
              "isObsolete": false,
              "name": "phosphatidic acid binding",
              "definition": {
                "text": "Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.",
                "xrefs": [
                  {
                    "dbCode": "CHEBI",
                    "dbId": "16337"
                  },
                  {
                    "dbCode": "ISBN",
                    "dbId": "0198506732"
                  }
                ]
              },
              "ancestors": [
                "GO:0043167",
                "GO:0036094",
                "GO:0008289",
                "GO:0070300",
                "GO:0043168",
                "GO:0005488",
                "GO:0005543",
                "GO:0003674"
              ],
              "synonyms": [
                {
                  "name": "phosphatidate binding",
                  "type": "exact"
                }
              ],
              "aspect": "molecular_function",
              "usage": "Unrestricted"
            }
          ],
          "pageInfo": null
        }
      },
      {
        "receipt": {
          "url": "https://www.ebi.ac.uk/QuickGO/services/ontology/go/terms/GO:1901612/ancestors?relations=is_a",
          "status": 200,
          "sha256": "df303985ef03dd921cdee71a85b08985a612ef179bbf86a99e6c192cf1b7132a",
          "bytes": 346,
          "retrieved_at": "2026-10-10T08:18:58.129020+00:00"
        },
        "response": {
          "numberOfHits": 1,
          "results": [
            {
              "id": "GO:1901612",
              "isObsolete": false,
              "name": "cardiolipin binding",
              "definition": {
                "text": "Binding to cardiolipin."
              },
              "ancestors": [
                "GO:0043167",
                "GO:0008289",
                "GO:0036094",
                "GO:1901611",
                "GO:0043168",
                "GO:0005543",
                "GO:0005488",
                "GO:1901612",
                "GO:0003674"
              ],
              "aspect": "molecular_function",
              "usage": "Unrestricted"
            }
          ],
          "pageInfo": null
        }
      }
    ]
  },
  "historical_artifact_audit": {
    "identities": [
      {
        "source_sha256": "f22a80392f09ad9599ad94eeaf50e7a009fbf6ce64fe4546cf7f0757fd61f1a8",
        "accession": "Q96NL8",
        "entry": "CF418_HUMAN",
        "genes": [
          {
            "geneName": {
              "evidences": [
                {
                  "evidenceCode": "ECO:0000312",
                  "source": "HGNC",
                  "id": "HGNC:27232"
                }
              ],
              "value": "CFAP418"
            },
            "synonyms": [
              {
                "value": "C8orf37"
              },
              {
                "value": "smalltalk"
              }
            ]
          }
        ],
        "sequence_length": 207,
        "retrieval": {
          "url": "https://rest.uniprot.org/uniprotkb/Q96NL8.json",
          "final_url": "https://rest.uniprot.org/uniprotkb/Q96NL8.json",
          "status": 200,
          "bytes": 25082,
          "sha256": "f22a80392f09ad9599ad94eeaf50e7a009fbf6ce64fe4546cf7f0757fd61f1a8",
          "retrieved_at": "2026-10-10T08:12:11.636470+00:00"
        }
      },
      {
        "source_sha256": "e610ab2b104a61f5f07103a7e111a59a5f1955fd5416e594282e9c0dbb526d68",
        "accession": "Q6ZT21",
        "entry": "TMPPE_HUMAN",
        "genes": [
          {
            "geneName": {
              "value": "TMPPE"
            }
          }
        ],
        "sequence_length": 453,
        "retrieval": {
          "url": "https://rest.uniprot.org/uniprotkb/Q6ZT21.json",
          "final_url": "https://rest.uniprot.org/uniprotkb/Q6ZT21.json",
          "status": 200,
          "bytes": 26643,
          "sha256": "e610ab2b104a61f5f07103a7e111a59a5f1955fd5416e594282e9c0dbb526d68",
          "retrieved_at": "2026-10-10T08:12:11.278396+00:00"
        }
      },
      {
        "source_sha256": "3a6d5b2a6f66e0123a2c02458b4a4cdbcb566b4a8c05bc0dd6ca31a3bd5ac48e",
        "accession": "Q9D4V0",
        "entry": "EKI1_MOUSE",
        "genes": [
          {
            "geneName": {
              "value": "Etnk1"
            },
            "synonyms": [
              {
                "value": "Eki1"
              }
            ]
          }
        ],
        "sequence_length": 363,
        "retrieval": {
          "url": "https://rest.uniprot.org/uniprotkb/Q8BXQ0.json",
          "final_url": "https://rest.uniprot.org/uniprotkb/Q9D4V0?from=Q8BXQ0",
          "status": 200,
          "bytes": 16047,
          "sha256": "3a6d5b2a6f66e0123a2c02458b4a4cdbcb566b4a8c05bc0dd6ca31a3bd5ac48e",
          "retrieved_at": "2026-10-10T08:12:12.063729+00:00"
        }
      },
      {
        "source_sha256": "296a0413ecbb9b865b4ff464f5d2e9bf2037cb13fd00d05164a8eb77459aba8a",
        "accession": "Q3UJP5",
        "entry": "CF418_MOUSE",
        "genes": [
          {
            "geneName": {
              "evidences": [
                {
                  "evidenceCode": "ECO:0000312",
                  "source": "MGI",
                  "id": "MGI:1914407"
                }
              ],
              "value": "Cfap418"
            }
          }
        ],
        "sequence_length": 209,
        "retrieval": {
          "url": "https://rest.uniprot.org/uniprotkb/Q3UJP5.json",
          "final_url": "https://rest.uniprot.org/uniprotkb/Q3UJP5.json",
          "status": 200,
          "bytes": 15596,
          "sha256": "296a0413ecbb9b865b4ff464f5d2e9bf2037cb13fd00d05164a8eb77459aba8a",
          "retrieved_at": "2026-10-10T08:12:11.285539+00:00"
        }
      }
    ],
    "historical_report": {
      "path": "genes/human/CFAP418/CFAP418-bioinformatics/RESULTS.md",
      "sha256": "785ff17b4d8dd4057116a9699127dec54729947cba355d8955eb68e94c23e6cc",
      "reported_accession": "Q6ZT21",
      "reported_length": 453,
      "scope": "This is TMPPE, not CFAP418. Its coiled-coil and motif conclusions must not support the CFAP418 review."
    },
    "sequence_files": [
      {
        "path": "genes/human/CFAP418/CFAP418-bioinformatics/CFAP418.fasta",
        "sha256": "4f2771312d9e98165ed85b06533aa0f79d0d99f94b94e7df0eab898d70dee327",
        "raw_sequence_length": 209,
        "non_amino_acid_characters": [
          {
            "position": 208,
            "character": "/"
          },
          {
            "position": 209,
            "character": "/"
          }
        ],
        "equals_current_human_sequence": false,
        "equals_current_mouse_sequence": false
      },
      {
        "path": "genes/human/CFAP418/CFAP418-bioinformatics/data/CFAP418_mouse.fasta",
        "sha256": "16fd6c2c397f20375f78ae3210f692b0aa6dc8501dbc65fb5a868f57d4e89c7d",
        "raw_sequence_length": 363,
        "non_amino_acid_characters": [],
        "equals_current_human_sequence": false,
        "equals_current_mouse_sequence": false
      },
      {
        "path": "genes/human/CFAP418/CFAP418-bioinformatics/data/CFAP418_human.fasta",
        "sha256": "2638e70ac11f1f7be9e2c0469e55198285f2f8f3887c5cba230a181638895c84",
        "raw_sequence_length": 207,
        "non_amino_acid_characters": [],
        "equals_current_human_sequence": true,
        "equals_current_mouse_sequence": false
      }
    ],
    "disposition": "Preserve all historical bytes, flag source-specific identity/parsing errors, and remove their support for current functional conclusions. No new predictive analysis is claimed."
  },
  "prior_authored_process_disposition": [
    {
      "prior_index": 8,
      "term": {
        "id": "GO:0001754",
        "label": "eye photoreceptor cell differentiation"
      },
      "original_reference_id": null,
      "disposition": "WITHDRAW_PRIOR_AUTHORED_NEW",
      "reason": "No experimentally established differentiation step performed by CFAP418; degeneration/morphology phenotypes and necessity do not establish the proposed process.",
      "prior_object_sha256": "b1e66c0acebf53b9513bdbdd5f3afd1887fa65b3f250e325af8185b605547a51"
    },
    {
      "prior_index": 9,
      "term": {
        "id": "GO:0030030",
        "label": "cell projection organization"
      },
      "original_reference_id": null,
      "disposition": "WITHDRAW_PRIOR_AUTHORED_NEW",
      "reason": "The broad cell-projection proposal relied on an unsupported scaffold interpretation and overlaps more specific prior proposals.",
      "prior_object_sha256": "ab6225874332076e83d1613879858e1b125ac78e17b3964a2e3bc28991c4c49b"
    },
    {
      "prior_index": 10,
      "term": {
        "id": "GO:0042073",
        "label": "intraciliary transport"
      },
      "original_reference_id": null,
      "disposition": "WITHDRAW_PRIOR_AUTHORED_NEW",
      "reason": "The zebrafish transport assay is perinuclear melanosome retrieval in melanophores, not intraciliary transport. Later ciliary trafficking phenotypes do not demonstrate CFAP418 executing IFT.",
      "prior_object_sha256": "c7b8b7f7a056fe092bc1cf694c15ebc71713437054d1c8f0214f451fce6494ba"
    },
    {
      "prior_index": 11,
      "term": {
        "id": "GO:0035845",
        "label": "photoreceptor cell outer segment organization"
      },
      "original_reference_id": null,
      "disposition": "WITHDRAW_PRIOR_AUTHORED_NEW",
      "reason": "Outer-segment organization is now the source-preserving refinement of existing row 5; a separate authored duplicate is unnecessary.",
      "prior_object_sha256": "74734fac3fbf85d85a858bd88ad8b8322d615cb7a3b8d241747ff908dabaa373"
    }
  ],
  "gocam": {
    "main": "8a69f3d2b551d632a37bfeb6217a7d667db8d51b",
    "blob": "46af2b7fe5797163f10a411b078927ce3d3ebdf1",
    "sha256": "2d6a795229f10d6a62ef9e7fd0f5c95b5c04d85b4114ad263b40e687280809dc",
    "hits": [],
    "interpretation": "No target result is not positive evidence for adding a function."
  },
  "source_access": [
    {
      "reference": "PMID:22177090",
      "selected_cache_sha256": "fde1e885996982a6091630ce3372509637c357ac320bbc26ddf3bc5eb0cfdbe7",
      "cache_scope": "abstract-only",
      "additional_full_normal_sha256": "1c16665c3978835bc7d5d676553844bed009c50cc6ae714fdba7cec7de2bab4f",
      "external_receipt": {
        "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257957/?report=xml",
        "final_url": "https://pmc.ncbi.nlm.nih.gov:443/articles/PMC3257957/?report=xml",
        "status": 200,
        "bytes": 200110,
        "sha256": "b512f9d849b9121d65c817670c5ddab68603df9ec13198b36ec56038d382c850",
        "retrieved_at": "2026-10-10T08:12:14.006767+00:00"
      },
      "read_scope": "Human hTERT-RPE1 cytoplasm/ciliary-base localization, bovine-extract antibody check and separate mouse retina Figure 3 observations.",
      "limitations": "No knockout disc experiment; later mouse antibody concerns do not erase original human IDA."
    },
    {
      "reference": "PMID:27173435",
      "selected_cache_sha256": "51454df67afa09560b3e4c5bbc815aaba39814a7e7f0d33dff9b3b0db1ed4c01",
      "cache_scope": "full",
      "read_scope": "Selected Results ciliary landscape and Methods affinity purification, human cDNA constructs, HEK293T host, tandem tags, MS and socioaffinity context; exact target pair from literal IntAct records.",
      "limitations": "No purified binary binding or calpain regulation established; supplement-wide screen not reanalysed."
    },
    {
      "reference": "PMID:36233334",
      "selected_cache_sha256": "65bacbe50d79d4989943ebf28684a0927ae44092531543bdab5ac413666c456f",
      "cache_scope": "full",
      "read_scope": "Selected Results and Methods on full-length human Y2H, fragment self-activation, tagged human HEK293 PLA and separate marmoset retinal staining/proximity.",
      "limitations": "No co-IP reported; fragment and antibody limitations retained, no scaffold or microtubule-activity transfer."
    },
    {
      "reference": "PMID:27008867",
      "selected_cache_sha256": "b4e1a878707040be66388fa4e2ad43190af0955177d2118670a0b2e2438890fa",
      "cache_scope": "flagged full but missing critical Methods/Results",
      "external_receipt": {
        "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081059/?report=xml",
        "final_url": "https://pmc.ncbi.nlm.nih.gov:443/articles/PMC5081059/?report=xml",
        "status": 200,
        "bytes": 239411,
        "sha256": "22059eb1197acc496130ef06dcedece378654dacdf0cc9de93882e0328c86555",
        "retrieved_at": "2026-10-10T08:12:14.095025+00:00"
      },
      "read_scope": "Actual full Methods and selected Results: zebrafish constructs/morpholinos/rescue, melanophore melanosomes and Kupffer vesicle phenotype.",
      "limitations": "No human construct assumption or direct IFT performance."
    },
    {
      "reference": "PMID:29440555",
      "selected_cache_sha256": "b32d42b8cdc787c6aedd1a2552469985505b041db249fa122a32d681743aaa92",
      "cache_scope": "full normal new cache",
      "read_scope": "Mouse alleles, retinal disc ultrastructure, antibody knockout controls, tagged mouse and endogenous rat localization, and full-length mouse cloning Methods.",
      "limitations": "No direct human assay or proof of a specific disc-building molecular step."
    },
    {
      "reference": "PMID:37971880",
      "selected_cache_sha256": "5d7666754488a1542fa6c0b5ffba0f897b5897999fd274460ac44ccbd14f9386",
      "cache_scope": "full normal new cache",
      "supplement_receipt": {
        "url": "https://insight.jci.org/articles/view/162621/sd/pdf/render/1",
        "final_url": "https://df6sxcketz7bb.cloudfront.net/manuscripts/162000/162621/jci.insight.162621.sd.pdf",
        "status": 200,
        "content_type": "application/pdf",
        "bytes": 20715991,
        "sha256": "65bb770a9eec743cbd46a52756826752c4af4399e273513f6e9eeb4fa0249524",
        "retrieved_at": "2026-10-10T08:16:21.156844+00:00"
      },
      "read_scope": "Selected full Results/Discussion on lipid overlays, lipid/retinal effects, RAB28 association, PRKCA readout and protein-folding tests. Independent peer read supplemental Methods and visually inspected Figure 8A, S1 and S11A.",
      "limitations": "Mouse full-length tagged proteins, immobilized-lipid overlays; no human IDA, tag cleavage, liposome/affinity assay, autonomous kinase or direct lipid-transfer/sequestration mechanism."
    }
  ],
  "followup_4553_artifact_correction": {
    "source_head": "3624e2fccc15b3b6ba45bcbd1a8ad7f3bf173581",
    "date": "2026-10-10",
    "identity_records": [
      {
        "query_accession": "Q6ZT21",
        "url": "https://rest.uniprot.org/uniprotkb/Q6ZT21.json",
        "final_url": "https://rest.uniprot.org/uniprotkb/Q6ZT21.json",
        "status": 200,
        "sha256": "e610ab2b104a61f5f07103a7e111a59a5f1955fd5416e594282e9c0dbb526d68",
        "primary_accession": "Q6ZT21",
        "secondary_accessions": [
          "B2RNG5",
          "Q6ZRG1"
        ],
        "gene": [
          {
            "geneName": {
              "value": "TMPPE"
            }
          }
        ],
        "length": 453
      },
      {
        "query_accession": "Q96NL8",
        "url": "https://rest.uniprot.org/uniprotkb/Q96NL8.json",
        "final_url": "https://rest.uniprot.org/uniprotkb/Q96NL8.json",
        "status": 200,
        "sha256": "f22a80392f09ad9599ad94eeaf50e7a009fbf6ce64fe4546cf7f0757fd61f1a8",
        "primary_accession": "Q96NL8",
        "secondary_accessions": [
          "F4Y588"
        ],
        "gene": [
          {
            "geneName": {
              "evidences": [
                {
                  "evidenceCode": "ECO:0000312",
                  "source": "HGNC",
                  "id": "HGNC:27232"
                }
              ],
              "value": "CFAP418"
            },
            "synonyms": [
              {
                "value": "C8orf37"
              },
              {
                "value": "smalltalk"
              }
            ]
          }
        ],
        "length": 207
      },
      {
        "query_accession": "Q8BXQ0",
        "url": "https://rest.uniprot.org/uniprotkb/Q8BXQ0.json",
        "final_url": "https://rest.uniprot.org/uniprotkb/Q9D4V0?from=Q8BXQ0",
        "status": 200,
        "sha256": "3a6d5b2a6f66e0123a2c02458b4a4cdbcb566b4a8c05bc0dd6ca31a3bd5ac48e",
        "primary_accession": "Q9D4V0",
        "secondary_accessions": [
          "F6Y9V2",
          "Q8BXQ0"
        ],
        "gene": [
          {
            "geneName": {
              "value": "Etnk1"
            },
            "synonyms": [
              {
                "value": "Eki1"
              }
            ]
          }
        ],
        "length": 363
      },
      {
        "query_accession": "Q3UJP5",
        "url": "https://rest.uniprot.org/uniprotkb/Q3UJP5.json",
        "final_url": "https://rest.uniprot.org/uniprotkb/Q3UJP5.json",
        "status": 200,
        "sha256": "296a0413ecbb9b865b4ff464f5d2e9bf2037cb13fd00d05164a8eb77459aba8a",
        "primary_accession": "Q3UJP5",
        "secondary_accessions": [
          "Q6PDD5"
        ],
        "gene": [
          {
            "geneName": {
              "evidences": [
                {
                  "evidenceCode": "ECO:0000312",
                  "source": "MGI",
                  "id": "MGI:1914407"
                }
              ],
              "value": "Cfap418"
            }
          }
        ],
        "length": 209
      }
    ],
    "sequence_comparison": {
      "source_file": "genes/human/CFAP418/CFAP418-bioinformatics/data/CFAP418_mouse.fasta",
      "original_header": ">Q8BXQ0 CFAP418 Mus musculus",
      "sequence_length": 363,
      "sequence_sha256": "ca5dbfb7edceb2203c27dd6124ad5e7a4f59689e4e6a8c014e994cb7a258842b",
      "matched_exactly": "Q9D4V0",
      "query_accession": "Q8BXQ0",
      "gene": "Etnk1",
      "species": {
        "scientificName": "Mus musculus",
        "commonName": "Mouse",
        "taxonId": 10090,
        "lineage": [
          "Eukaryota",
          "Metazoa",
          "Chordata",
          "Craniata",
          "Vertebrata",
          "Euteleostomi",
          "Mammalia",
          "Eutheria",
          "Euarchontoglires",
          "Glires",
          "Rodentia",
          "Myomorpha",
          "Muroidea",
          "Muridae",
          "Murinae",
          "Mus",
          "Mus"
        ]
      },
      "no_sequence_substitution": true
    },
    "edited_authored_paths": [
      "CFAP418-bioinformatics/RESULTS.md",
      "CFAP418-bioinformatics/README.md",
      "CFAP418-bioinformatics/data/CFAP418_mouse.fasta"
    ],
    "original_bodies_retained": true,
    "sequence_bytes_after_header_unchanged": true,
    "new_analysis_performed": false,
    "primary_context": {
      "reference": "PMID:37971880",
      "locator": "Figure 4 Results; mitochondrial protein expression and morphology",
      "observations": [
        "PGS1 reduction in P5/P10 knockout retina",
        "altered mitochondrial shape in photoreceptors",
        "relatively preserved position/cristae and tested oxygen consumption"
      ],
      "interpretive_limit": "Does not demonstrate CFAP418 mitochondrial localization or direct cardiolipin binding in vivo."
    }
  }
}
