Colipase-like protein 1, member of colipase family. Similar to CLPS and CLPSL2 with colipase domain structure. Putative lipase cofactor that may facilitate enzyme-substrate interactions for lipolytic enzymes in specific tissues. Expression pattern suggests tissue-specific or developmental role. Secreted protein functioning extracellularly. Function incompletely characterized but likely involved in lipid metabolism or digestion-related processes.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0008047 enzyme activator activity | IBA GO_REF:0000033 | ACCEPT | Summary: Enzyme activator activity - colipase cofactor function. Reason: Putative core function. Supporting Evidence: file:human/CLPSL1/CLPSL1-deep-research-perplexity.md See deep research file for comprehensive analysis |
| GO:0005576 extracellular region | IEA GO_REF:0000120 | ACCEPT | Summary: Extracellular region - secreted protein. Reason: Core localization. |
| GO:0007586 digestion | IEA GO_REF:0000002 | ACCEPT | Summary: Digestion - may function in digestive lipid processing. Reason: KEEP_AS_NON_CORE |
| GO:0008047 enzyme activator activity | IEA GO_REF:0000002 | ACCEPT | Summary: Enzyme activator activity - colipase cofactor function. Reason: Putative core function. |
| GO:0016042 lipid catabolic process | IEA GO_REF:0000002 | ACCEPT | Summary: Lipid catabolic process - lipolysis. Reason: KEEP_AS_NON_CORE |
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Download this section (compressed HTML)Q: What lipase enzyme does CLPSL1 activate and in which physiological context?
Suggested experts: Lipid biochemists
Experiment: Lipase activity assays with recombinant CLPSL1
Hypothesis: CLPSL1 enhances lipase activity
Type: biochemical assay
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