# CRYAB Gene Review Notes

## 2026-05-30 - PROTEOSTASIS PN small-HSP positive-control pass

Full review is present and marked complete. The local review supports CRYAB/HSPB5 as a small heat-shock-protein molecular chaperone with holdase activity. It modifies `GO:0051082 unfolded protein binding` to `GO:0140309 unfolded protein carrier activity` and treats `GO:0042026 protein refolding` as an imprecise foldase-style term for CRYAB biology. [file:human/CRYAB/CRYAB-ai-review.yaml; PMID:16303126; PMID:12235146]

PN curation conclusion: the PN small-HSP placements are appropriate, including cytonuclear and stress-context branches. The same caution as CRYAA applies: PN-derived chaperone propagation is valid at the small-HSP/holdase level, but should not erase the distinction between ATP-independent holdase activity and ATP-dependent protein refolding.