CTNNB1 encodes beta-catenin, a 781-residue armadillo-repeat protein that connects cadherin-based cell adhesion with Wnt-responsive transcription. At adherens junctions, its armadillo-repeat groove binds cadherin cytoplasmic tails and its N-terminal region recruits alpha-catenin, linking the cadherin complex to the force-responsive actin-associated junctional machinery. A regulated cytoplasmic pool binds APC and AXIN in the destruction complex, where CK1/GSK3 phosphorylation enables beta-TrCP-mediated ubiquitination and turnover. Canonical Wnt signaling stabilizes beta-catenin and promotes its nuclear association with TCF/LEF factors and transcriptional coactivators, activating context-dependent target genes. It also binds nuclear receptors and other regulatory partners. Its C-terminal PDZ-binding sequence supports selected scaffold interactions, while a centrosomal pool participates in centriole cohesion. These molecular activities contribute to developmental patterning, tissue homeostasis and context-dependent proliferation or differentiation; stabilizing mutations and destruction-complex defects contribute to tumorigenesis.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000209 protein polyubiquitination | IDA PMID:29374064 Forkhead Box F2 Suppresses Gastric Cancer through a Novel FO... | REMOVE | Summary: protein polyubiquitination: the specific source assignment is contradicted or assigns the wrong performed role. Reason: The actual publisher-indexed Results and Figure5 identify beta-catenin as the ubiquitinated substrate: FOXF2 raises IRF2BPL expression, and IRF2BPL perturbation changes beta-catenin ubiquitination and turnover in gastric-cancer cells. These experiments do not show beta-catenin performing ubiquitin-chain addition, the activity described by GO:0000209. Retain the original experimental source assertion and its provenance while rejecting this process assignment; this does not dispute the observed beta-catenin modification. Supporting Evidence: PMID:29374064 IRF2BPL in turn interacted with ฮฒ-catenin, increasing its ubiquitination and degradation |
| GO:0000785 chromatin | ISS GO_REF:0000024 | ACCEPT | Summary: chromatin: supported at the stated source and biological scope. Reason: Consistent with ChIP and in vitro chromatin-template studies showing beta-catenin on chromatin with LEF-1. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q9WU82: 0 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: RGD:70487 SOURCE STALE OR MISSING Resolved accession Q9WU82. No exact experimental term row in the captured current snapshot; check descendants and model provenance before treating this as a biological failure. Supporting Evidence: PMID:11751639 recombinant beta-catenin strongly enhances binding and transactivation by LEF-1 on chromatin templates in vitro |
| GO:0000791 euchromatin | IDA PMID:22723415 Wnt/ฮฒ-catenin signaling regulates telomerase in stem cells a... | KEEP AS NON CORE | Summary: euchromatin: retain the positive contextual association or function. Reason: Reflects promoter occupancy via DNA-binding partners; correct but peripheral to the core coactivator function. Supporting Evidence: PMID:22723415 ฮฒ-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells |
| GO:0000791 euchromatin | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: euchromatin: retain the positive contextual association or function. Reason: Reflects promoter occupancy via DNA-binding partners; correct but peripheral to the core coactivator function. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244611; references PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:22723415 ฮฒ-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells |
| GO:0000922 spindle pole | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: spindle pole: retain the positive contextual association or function. Reason: Beta-catenin localizes to centrosomes, where NEK2 phosphorylates it and it contributes to centrosome cohesion; a real but secondary location. Supporting Evidence: PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome separation |
| GO:0001221 transcription coregulator binding | IEA GO_REF:0000107 | ACCEPT | Summary: transcription coregulator binding: supported at the stated source and biological scope. Reason: Beta-catenin binds coregulators such as BCL9/BCL9L, TBL1/TBLR1, CBP/p300 and parafibromin as part of its coactivator mechanism. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244237; references PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0001221 transcription coregulator binding | ISS GO_REF:0000024 | ACCEPT | Summary: transcription coregulator binding: supported at the stated source and biological scope. Reason: Beta-catenin binds coregulators such as BCL9/BCL9L, TBL1/TBLR1, CBP/p300 and parafibromin as part of its coactivator mechanism. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244237; references PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0001222 transcription corepressor binding | IPI PMID:30097457 FLYWCH1, a Novel Suppressor of Nuclear ฮฒ-Catenin, Regulates ... | UNDECIDED | Summary: transcription corepressor binding: the specific source or functional scope remains unresolved. Reason: PMID:30097457 directly supports FLYWCH1 binding to beta-catenin and inhibition of beta-catenin/TCF-dependent transcription, including recombinant binding, competition and reporter assays. The current GO:0001222 definition additionally specifies a corepressor that mediates interactions with basal transcription machinery. That partner-class mechanism is not established by the inspected source, so the specific assertion remains unresolved while the positive interaction and repression are retained. Motif predictions and extract-containing EMSA/ChIP do not independently establish intrinsic sequence-specific FLYWCH1 DNA binding or justify an exclusion on that basis. No replacement or negative-binding assertion is proposed. Supporting Evidence: |
| GO:0001649 osteoblast differentiation | IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m... | KEEP AS NON CORE | Summary: osteoblast differentiation: retain the positive contextual association or function. Reason: The actual source uses human bone-marrow stromal cells from three donors. In the miR346/GSK3beta context, beta-catenin knockdown suppresses the enhanced ALP endpoint, with nuclear accumulation and TCF/LEF reporter activation supporting the Wnt-dependent differentiation response. Preserve this positive human osteogenic context as non-core; it is not a mouse transfer and does not establish an autonomous osteoblast-specific biochemical activity. Supporting Evidence: |
| GO:0001837 epithelial to mesenchymal transition | TAS PMID:14679171 Epithelial-mesenchymal transition and its implications for f... | KEEP AS NON CORE | Summary: epithelial to mesenchymal transition: retain the positive contextual association or function. Reason: Beta-catenin/TCF target genes contribute to EMT in fibrosis and cancer; a downstream context, kept as non-core. Supporting Evidence: |
| GO:0002052 positive regulation of neuroblast proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of neuroblast proliferation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244073, 417244422; references PMID:21937711, PMID:21325504. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0002052 positive regulation of neuroblast proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of neuroblast proliferation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244073, 417244422; references PMID:21937711, PMID:21325504. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0003151 outflow tract morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: outflow tract morphogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244423; references PMID:12464179. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0003151 outflow tract morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: outflow tract morphogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244423; references PMID:12464179. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0003682 chromatin binding | IEA GO_REF:0000107 | ACCEPT | Summary: chromatin binding: supported at the stated source and biological scope. Reason: The actual mouse Q02248 source has 23 experimental chromatin-binding records with locus/cell extensions. Independently, the human beta-cateninโLEF1 chromatin-template experiments in PMID:11751639 demonstrate cooperative chromatin association and transcriptional function. GO:0003682 does not require intrinsic sequence-specific DNA binding. Preserve partner-mediated chromatin binding, without claiming every mouse locus or cell context was tested in human cells. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244241, 417244242, 417244243, 417244244 and further distinct loci/contexts; references PMID:15024079, PMID:15778706, PMID:15907834. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0003682 chromatin binding | ISS GO_REF:0000024 | ACCEPT | Summary: chromatin binding: supported at the stated source and biological scope. Reason: The actual mouse Q02248 source has 23 experimental chromatin-binding records with locus/cell extensions. Independently, the human beta-cateninโLEF1 chromatin-template experiments in PMID:11751639 demonstrate cooperative chromatin association and transcriptional function. GO:0003682 does not require intrinsic sequence-specific DNA binding. Preserve partner-mediated chromatin binding, without claiming every mouse locus or cell context was tested in human cells. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244241, 417244242, 417244243, 417244244 and further distinct loci/contexts; references PMID:15024079, PMID:15778706, PMID:15907834. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0003713 transcription coactivator activity | IBA GO_REF:0000033 | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: Direct human chromatin coactivation supports the target function. The actual ancestral placement is supported by the reconstructed tree, alignment and experimental descendant records; donor count or historical evolutionary prose is not a substitute for those data. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 7 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00000238 SUPPORTS TRANSFER Resolved to Q18825; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00006943 SUPPORTS TRANSFER Resolved to Q10953; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 9 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0003713 transcription coactivator activity | IDA PMID:11751639 Chromatin-specific regulation of LEF-1-beta-catenin transcri... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: The human beta-catenin/LEF1 reconstitution directly measures transcription from chromatin, with dependence on the beta-catenin activation region. Beta-catenin supplies coactivation rather than intrinsic sequence-specific DNA binding. Purified p300 and a partially purified remodeling fraction assist the reaction; their catalytic activities are not assigned to beta-catenin. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0003713 transcription coactivator activity | IDA PMID:12651860 The cohesin SMC3 is a target the for beta-catenin/TCF4 trans... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0003713 transcription coactivator activity | IDA PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Supporting Evidence: PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis |
| GO:0003713 transcription coactivator activity | IDA PMID:22187462 Structural basis of coactivation of liver receptor homolog-1... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: Retain the established coactivator assertion with curator deference and independent direct 11751639 support. The accessible original 22187462 structural sections establish a human LRH1โbeta-catenin interface; its complete functional assay and supplementary Methods were not recovered here. Do not describe a new reporter experiment in that paper from its title or structure alone. Supporting Evidence: PMID:22187462 as the first structure of ฮฒ-catenin in complex with any nuclear receptor PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0003713 transcription coactivator activity | IDA PMID:9065402 Activation of beta-catenin-Tcf signaling in colon cancer by ... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0003713 transcription coactivator activity | IEA GO_REF:0000107 | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 9 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244267, 417244268, 417244269, 417244270 and further distinct loci/contexts; references PMID:12235125, PMID:12464179, PMID:12949260. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0003713 transcription coactivator activity | IMP PMID:12949260 Wnt4 overexpression disrupts normal testicular vasculature a... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0003713 transcription coactivator activity | IMP PMID:15905404 Functional interaction between beta-catenin and FOXO in oxid... | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Supporting Evidence: PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0003713 transcription coactivator activity | ISS GO_REF:0000024 | ACCEPT | Summary: transcription coactivator activity: supported at the stated source and biological scope. Reason: This is the core nuclear function of beta-catenin, established biochemically and genetically. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q9WU82: 0 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: RGD:70487 SOURCE STALE OR MISSING Resolved accession Q9WU82. No exact experimental term row in the captured current snapshot; check descendants and model provenance before treating this as a biological failure. Supporting Evidence: PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005102 signaling receptor binding | IPI PMID:30683932 TREM2 acts as a tumor suppressor in hepatocellular carcinoma... | KEEP AS NON CORE | Summary: signaling receptor binding: retain the positive contextual association or function. Reason: The partner is a receptor, so the term is formally correct, but it says little about beta-catenin function; kept as non-core. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:10706604 Pleiotrophin signals increased tyrosine phosphorylation of b... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The actual PTN-Fc crosslinking experiment recovers a PTPRZ1โbeta-catenin complex, whereas the separate PTPRZ1 catalytic-domain capture supports phosphatase binding. PTN is a ligand, not a phosphatase. Preserve both source partners and the positive complex association as non-core rather than assigning the same enzyme class to the entire mixed assertion. Supporting Evidence: PMID:10706604 We also have found that an active site-containing domain of RPTP beta/zeta both binds beta-catenin |
| GO:0005515 protein binding | IPI PMID:10706604 Pleiotrophin signals increased tyrosine phosphorylation of b... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The original study captures beta-catenin from U373-MG lysate with recombinant human PTPRZ1 D1 (residues 1655โ2018), including the C1925S trapping construct; active D1 also decreases beta-catenin phosphotyrosine. This supports protein phosphatase binding. The lysate capture is distinct from the indirect PTN-Fc crosslinked complex and does not establish purified binary binding of full-length receptors. Proposed replacements: protein phosphatase binding Supporting Evidence: PMID:10706604 We also have found that an active site-containing domain of RPTP beta/zeta both binds beta-catenin |
| GO:0005515 protein binding | IPI PMID:10725230 ARVCF localizes to the nucleus and adherens junction and is ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:10725230 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:10773885 Regulation and function of the interaction between the APC t... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:10773885 assertion concerns APC (P25054). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:10773885 Regulation and function of the interaction between the APC t... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The available source abstract describes APCโEB1/MAPRE1 relationships, but the exact beta-cateninโMAPRE1 assay was not recovered and no matching current literal interaction was found. Preserve the curated positive assertion as unresolved; this is not evidence that beta-catenin cannot associate with MAPRE1. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:10825188 Differential mechanisms of LEF/TCF family-dependent transcri... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:10825188 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:10987273 Beta-catenin affects androgen receptor transcriptional activ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:10987273 assertion concerns AR (P10275). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative nuclear receptor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0005515 protein binding | IPI PMID:11401320 FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pa... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:11401320 assertion concerns FGFR1 (P11362). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:11401320 FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pa... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:11401320 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:11533658 Pin1 regulates turnover and subcellular localization of beta... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:11533658 assertion concerns APC (P25054). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:11590244 alphaT-catenin: a novel tissue-specific beta-catenin-binding... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:11590244 assertion concerns CTNNA3 (Q9UI47). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:11590244 alphaT-catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:11713475 Tcf4 can specifically recognize beta-catenin using alternati... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:11713475 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using x-ray crystallography. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:11713475 Tcf4 can specifically recognize beta-catenin using alternative conformations PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:11713476 Structure of a human Tcf4-beta-catenin complex. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: TCF7L2 is a sequence-specific Pol II transcription factor. Its human 8โ54 fragment directly contacts human beta-catenin 134โ668 in the purified structure; the same original reports TCF-site-dependent cellular reporter assays and binding-interface mutants. The current Pol II-specific binding child is more informative than the older broad DNA-binding-transcription-factor binding replacement. Fragment binding does not assign DNA binding to beta-catenin. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:11713476 it interacts with the Adenomatous polyposis coli (APC) protein and TCF/Lef family transcription factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:11751639 Chromatin-specific regulation of LEF-1-beta-catenin transcri... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: Preserve the positive ICAT/CTNNBIP1 interaction under the standing project instruction. The original directly demonstrates ICAT-dependent inhibition in the LEF1โbeta-catenin chromatin system. At transcription-inhibiting concentrations, cooperative LEF1/beta-catenin occupancy can persist; simple competition is not an exhaustive mechanism. Inhibition of a coactivator does not by itself establish the more specific basal-machinery/coregulator role described by GO:0001221 or GO:0001222. Retaining generic binding avoids inventing that partner class, while rejecting neither binding nor transcriptional inhibition. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:11790773 Protein binding and functional characterization of plakophil... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:11790773 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:11790773 Protein binding and functional characterization of plakophil... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:11790773 assertion concerns PKP2 (Q99959). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:11955446 Wnt/wingless signaling requires BCL9/legless-mediated recrui... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:11955446 assertion concerns BCL9 (O00512). The exact current interaction records recover this positive pair using two hybrid, pull down. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:11955446 we provide genetic and molecular evidence that these proteins exert their function by physically linking Pygo to beta-catenin PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:12297051 Adenovirus fiber disrupts CAR-mediated intercellular adhesio... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:12297051 assertion concerns CXADR (P78310). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:12370829 The transmembrane receptor protein tyrosine phosphatase DEP1... | REMOVE | Summary: protein binding: the specific source assignment is contradicted or assigns the wrong performed role. Reason: The literal positive MINT-7026844 / EBI-8544136 record cites Figure 3, but the recovered original Results, Figure 3B and GST catalytic-D1 pull-down Methods show no detectable beta-catenin band for the tested CD45 D/A constructs, with the positive band restricted to DEP1 D/A plus pervanadate. Remove this source-specific positive association because its cited experiment contradicts it; preserve the raw record and disclose the disagreement. This is not removal for genericity, a NOT assertion, or a claim about other CD45 contexts. Supporting Evidence: PMID:12370829 Catalytic domains of the tyrosine phosphatases PTP-PEST, CD45, and PTPbeta did not interact with proteins of the catenin family to detectable levels |
| GO:0005515 protein binding | IPI PMID:12370829 The transmembrane receptor protein tyrosine phosphatase DEP1... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:12370829 assertion concerns PTPRJ (Q12913). The exact current interaction records recover this positive pair using pull down. The partner identity and the reported interaction support the more informative protein phosphatase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein phosphatase binding Supporting Evidence: PMID:12370829 DEP1 also interacted with other members of the catenin gene family including beta-catenin and gamma-catenin |
| GO:0005515 protein binding | IPI PMID:12408824 The crystal structure of the beta-catenin/ICAT complex revea... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:12408824 assertion concerns CTNNBIP1 (Q9NSA3). The exact current interaction records recover this positive pair using x-ray crystallography. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:12421363 Axin negatively affects tau phosphorylation by glycogen synt... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:12421363 assertion concerns Axin1 (O35625). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:12734196 Characterization of cadherin-24, a novel alternatively splic... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:12734196 assertion concerns CDH24 (Q86UP0-1). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:12734196 Characterization of cadherin-24, a novel alternatively splic... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:12734196 assertion concerns CDH24 (Q86UP0-2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:12820959 Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruc... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:12820959 assertion concerns BTRC (Q9Y297). The exact current interaction records recover this positive pair using x-ray crystallography. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:12927518 IpaC of Shigella binds to the C-terminal domain of beta-cate... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:12927518 assertion concerns sctB (P18012). The exact current interaction records recover this positive pair using two hybrid, coimmunoprecipitation, imaging technique, pull down. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:14595118 Novel membrane protein shrew-1 targets to cadherin-mediated ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:14595118 assertion concerns AJAP1 (Q9UKB5). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:14600025 Crystal structure of a beta-catenin/axin complex suggests a ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:14600025 assertion concerns axin1 (Q9YGY0). The exact current interaction records recover this positive pair using x-ray crystallography. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:15110721 Sox1 acts through multiple independent pathways to promote n... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:15110721 assertion concerns Sox1 (P53783). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:15110721 Sox1 also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:15327768 Mechanism of phosphorylation-dependent binding of APC to bet... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:15327768 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using x-ray crystallography. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:15327769 Crystal structure of a beta-catenin/APC complex reveals a cr... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:15327769 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using x-ray crystallography, isothermal titration calorimetry. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:15843474 Cited1 is a bifunctional transcriptional cofactor that regul... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:15843474 assertion concerns EP300 (Q09472). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative histone acetyltransferase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: histone acetyltransferase binding Supporting Evidence: PMID:21751375 p300/CBP (CREB-binding protein) is recruited by nuclear ฮฒ-catenin to regulate a wide array of T-cell factor (TCF)-dependent gene expression |
| GO:0005515 protein binding | IPI PMID:15843474 Cited1 is a bifunctional transcriptional cofactor that regul... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:15843474 assertion concerns CITED1 (Q99966). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:16204054 E-cadherin regulates the association between beta-catenin an... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The literal two-hybrid records pair ACTN4 residues 28โ189 with beta-catenin residues 1โ249. ACTN4 is an alpha-actinin, so alpha-actinin binding is an informative partner-class refinement. The fragment assay does not establish binding of every alpha-actinin isoform or native junctional stoichiometry. Proposed replacements: alpha-actinin binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16212417 Biosensor-based micro-affinity purification for the proteomi... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16212417 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using surface plasmon resonance, pull down. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:16212417 Biosensor-based micro-affinity purification for the proteomi... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16212417 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using pull down. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16376880 The X protein of hepatitis B virus binds to the F box protei... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16376880 assertion concerns BTRC (Q9Y297). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:16424001 TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by reliev... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16424001 assertion concerns CBY1 (Q9Y3M2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16442529 Bcr interferes with beta-catenin-Tcf1 interaction. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16442529 assertion concerns TCF7 (P36402). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:16442529 Tcf1 in complex with beta-catenin is able to activate beta-catenin-dependent gene expression PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:16442529 Bcr interferes with beta-catenin-Tcf1 interaction. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16442529 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:16569639 Physiological and functional interactions between Tcf4 and D... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16569639 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:16574648 Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin sig... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The original PMID:16574648 Methods, Figure 3D caption and Figure 5A/B Results support association of PCP-2/PTPRU with beta-catenin. Later biochemical and structural analysis of human Q92729-1 (PMID:32591542) identifies catalytically inactive PTPRU, so the old enzyme-class inference to GO:0019903 is not adequately supported. Preserve the positive generic binding as non-core under the project instruction, with no invented specific replacement; pseudophosphatase status does not negate binding. The inherited excerpt records the older claimed dephosphorylation; the later catalytic evidence disputes that clause while preserving association. |
| GO:0005515 protein binding | IPI PMID:16630820 Parafibromin/Hyrax activates Wnt/Wg target gene transcriptio... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16630820 assertion concerns CDC73 (Q6P1J9). The exact current interaction records recover this positive pair using two hybrid, pull down, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:16630820 bind directly to the C-terminal region of beta-catenin/Armadillo PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:16630820 Parafibromin/Hyrax activates Wnt/Wg target gene transcriptio... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16630820 assertion concerns LEO1 (Q8WVC0). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16724116 HIC1 attenuates Wnt signaling by recruitment of TCF-4 and be... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16724116 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:16753179 The third 20 amino acid repeat is the tightest binding site ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16753179 assertion concerns APC (P25054). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16858403 The inner nuclear membrane protein emerin regulates beta-cat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16858403 assertion concerns EMD (P50402). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, filter binding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16890161 Caveolin is necessary for Wnt-3a-dependent internalization o... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16890161 assertion concerns Axin1 (O70239). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16968744 Nucleo-cytoplasmic shuttling of human Kank protein accompani... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:16968744 assertion concerns KANK1 (Q14678). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16983094 The von Hippel-Lindau tumor suppressor gene product represse... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:16983094 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17047063 E-cadherin regulates human Nanos1, which interacts with p120... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17047063 assertion concerns NANOS1 (Q8WY41). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17052462 Crystal structure of a beta-catenin/BCL9/Tcf4 complex. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17052462 assertion concerns BCL9 (O00512). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:17052462 Crystal structure of a beta-catenin/BCL9/Tcf4 complex. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17052462 assertion concerns CTNNA1 (P35221). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:17052462 without affecting cadherin or alpha-catenin binding PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:17052462 Crystal structure of a beta-catenin/BCL9/Tcf4 complex. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17052462 assertion concerns Bcl9l (Q67FY2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 does not directly affect the interaction of beta-catenin with either BCL9 or BCL9-2 PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:17057644 A distinct PAR complex associates physically with VE-cadheri... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17057644 assertion concerns CDH2 (P19022). The exact current interaction records recover this positive pair using pull down. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17057644 A distinct PAR complex associates physically with VE-cadheri... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17057644 assertion concerns CDH5 (P33151). The exact current interaction records recover this positive pair using imaging technique, pull down. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17057644 A distinct PAR complex associates physically with VE-cadheri... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17057644 assertion concerns PARD3 (Q8TEW0). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17098867 Pleiotrophin disrupts calcium-dependent homophilic cell-cell... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17098867 assertion concerns CDH2 (P19022). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:17098867 The levels of N-cadherin that coimmunoprecipitate with ฮฒ-catenin from lysates of nonstimulated and PTN-stimulated cells were compared PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17098867 Pleiotrophin disrupts calcium-dependent homophilic cell-cell... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17098867 assertion concerns CTNNA1 (P35221). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:17220478 Proteomics analysis of the interactome of N-myc downstream r... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17220478 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17220478 Proteomics analysis of the interactome of N-myc downstream r... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17220478 assertion concerns NDRG1 (Q92597). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17237808 Helicobacter pylori CagA interacts with E-cadherin and dereg... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17237808 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:17237808 The CagA/E-cadherin interaction impairs the complex formation between E-cadherin and beta-catenin PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17242191 NHERF1/EBP50 head-to-tail intramolecular interaction masks a... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17242191 assertion concerns NHERF1 (O14745). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:17242191 NHERF1/EBP50 head-to-tail intramolecular interaction masks a... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17242191 assertion concerns NHERF2 (Q15599). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:17283121 Ku70 and poly(ADP-ribose) polymerase-1 competitively regulat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17283121 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:17289029 The Krรผppel-like zinc finger protein Glis2 functions as a ne... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17289029 assertion concerns GLIS2 (Q9BZE0). The exact current interaction records recover this positive pair using two hybrid pooling approach, anti tag coimmunoprecipitation, pull down. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:17289029 This screening identified beta-catenin as a potential Glis2-interacting protein PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The literal partner A1Z199 is a BCRโABL fusion and the source reports beta-catenin association in that oncogenic kinase context. Protein kinase binding is supported for this fusion; it is not a claim that the corresponding wild-type BCR protein has ABL catalytic activity. Proposed replacements: protein kinase binding Supporting Evidence: PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17318191 assertion concerns AXIN1 (O15169). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17318191 assertion concerns ABL1 (P00519). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, protein kinase assay. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The original human Ku812 experiments positively co-immunoprecipitate beta-catenin with a nuclear TCF4 pool (Figures 1E and 7A). The Methods identify anti-TCF4 clone 6H5-3 and a dominant-negative construct lacking the beta-catenin-binding domain. This is HMG TCF/LEF context; the present manufacturer record maps the named antibody to TCF7L2/Q9NQB0, although its prose also contains mixed aliases. The original insert sequence and historical reagent lot were not independently established. Thus the exact P15884/E2-2 source assertion remains unresolved, while the positive TCF-family association is retained. Neither a negative P15884-binding claim nor substitution of Q9NQB0 into the machine source is justified. Supporting Evidence: PMID:17318191 This Y-phospho beta-catenin binds to the TCF4 transcription factor, thus representing a transcriptionally active pool |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17318191 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17318191 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:17318191 Axin/GSK3beta binding to beta-catenin and its subsequent S/T phosphorylation PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:17500595 Huntingtin interacting proteins are genetic modifiers of neu... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17500595 assertion concerns HTT (P42858). The exact current interaction records recover this positive pair using two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17510365 assertion concerns AXIN1 (O15169). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17510365 assertion concerns CDH2 (P19022). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17510365 assertion concerns APC (P25054). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17510365 assertion concerns TCF7 (P36402). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17510365 assertion concerns GSK3B (P49841). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17510365 assertion concerns AMER1 (Q5JTC6). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The curated TAP-MS source identifies this ARHGAP21 relationship, but the target-specific original assay/table was not recovered and the current literal records do not independently resolve it. The separate later PDZ-domain screen is a different construct and source. Keep this source assertion unresolved rather than transferring that later result into the historical assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17510365 assertion concerns CTNNBIP1 (Q9NSA3). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17510365 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17510365 assertion concerns FBXW11 (Q9UKB1). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:17510365 forms a complex with beta-catenin, AXIN1, beta-TrCP2 (beta-transducin repeat-containing protein 2), and APC PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17510365 assertion concerns AXIN2 (Q9Y2T1). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17513457 Paxillin-beta-catenin interactions are involved in Rac/Cdc42... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17513457 assertion concerns PXN (P49023). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17517646 Vitamin D receptor is essential for normal keratinocyte stem... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17517646 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:17679699 beta-Catenin regulates excitatory postsynaptic strength at h... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17679699 assertion concerns CDH2 (P19022). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:17679699 beta-Catenin regulates excitatory postsynaptic strength at h... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17679699 assertion concerns CTNNA2 (P26232). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:17785436 E-cadherin is required for caveolin-1-mediated down-regulati... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17785436 assertion concerns CAV1 (P33724). The exact current interaction records recover this positive pair using confocal microscopy, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17875931 Sox17 and Sox4 differentially regulate beta-catenin/T-cell f... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The recovered original Methods use human TCF4 cDNA and GST-TCF4, with TCF/LEF explicitly treated as HMG factors; selected Results show positive beta-catenin/TCF4 associations and Sox17-dependent complexes. Reciprocal HMG-deletion mapping concerns TCF3, not TCF4. This supports genuine TCF-family binding but does not establish the imported P15884/E2-2 identity. The historical human insert was not sequence-resolved here. Preserve the positive biological result and the original source tuple while marking its accession-specific interpretation unresolved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17875931 Sox17 and Sox4 differentially regulate beta-catenin/T-cell f... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:17875931 assertion concerns SOX17 (Q9H6I2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:17983804 Functional interaction of DNA topoisomerase IIalpha with the... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:17983804 assertion concerns TOP2A (P11388). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, fluorescence microscopy, two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17983804 Functional interaction of DNA topoisomerase IIalpha with the... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The complete accessible abstract and two literal IntAct spoke records report a positive TCF4/beta-catenin-containing association in DLD1 cells, with topoisomerase II beta. They do not resolve which historical TCF4 reagent underlies the imported P15884 accession, and the operative full Methods were not recovered. The ambiguity concerns the exact partner assignment, not whether the published Wnt-associated complex exists. Do not use an independent TCF7L2 paper to verify this P15884 assertion. Supporting Evidence: PMID:17983804 DNA topoisomerase IIalpha (Topo IIalpha) is a component of the beta-catenin/T-cell factor-4 (TCF-4) nuclear complex |
| GO:0005515 protein binding | IPI PMID:18077326 The tumor suppressor Fhit acts as a repressor of beta-cateni... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:18077326 assertion concerns FHIT (P49789). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18077326 The tumor suppressor Fhit acts as a repressor of beta-cateni... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18077326 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome sepa... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: Purified GST-beta-catenin/His-NEK2 binding with GST control supports this specific partner class; separate kinase assays validate NEK2 activity, not CTNNB1 catalysis. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome sepa... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: Rootletin co-immunoprecipitation supports a positive contextual complex association. The separately cited supplemental Far-Western was not personally inspected; no purified direct-interaction claim. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18087039 SUMOylation of pontin chromatin-remodeling complex reveals a... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:18087039 assertion concerns RUVBL1 (Q9Y265). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18193033 assertion concerns TBL1X (O60907). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18193033 assertion concerns TBL1XR1 (Q9BZK7). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:18287330 VE-cadherin and beta-catenin binding dynamics during histami... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18287330 assertion concerns CDH5 (P33151). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:18287330 Beta-catenin plays an important role in the regulation of vascular endothelial cell-cell adhesions and barrier function by linking the VE-cadherin junction complex to the cytoskeleton PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:18287330 VE-cadherin and beta-catenin binding dynamics during histami... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:18287330 assertion concerns CTNNBIP1 (Q9NSA3). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18354482 Control of chromosome stability by the beta-TrCP-REST-Mad2 a... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18354482 assertion concerns BTRC (Q9Y297). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:18356165 HDAC6 is required for epidermal growth factor-induced beta-c... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: Positive HDAC6 association is retained. The current official record emphasizes nonhistone deacetylation and cautions against treating the historical enzyme name as evidence of histone activity; the source concerns beta-catenin regulation. Retain protein binding as non-core without a histone-deacetylase class refinement. Supporting Evidence: PMID:23084749 CD133, HDAC6, and the central molecule of the canonical Wnt signaling pathway, ฮฒ-catenin, can physically associate as a ternary complex |
| GO:0005515 protein binding | IPI PMID:18456656 The molecular mechanism governing the oncogenic potential of... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18456656 assertion concerns SOX2 (P48431). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:18456656 we identified beta-catenin as the transcription partner for SOX2 PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:18509060 LRP6 transduces a canonical Wnt signal independently of Axin... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:18509060 assertion concerns axin1 (Q9YGY0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18591935 Mutated in colorectal cancer, a putative tumor suppressor fo... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:18591935 assertion concerns MCC (P23508). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18593713 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:18662404 The neurotransmitter dopamine modulates vascular permeabilit... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18662404 assertion concerns CDH5 (P33151). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:18662404 We found VEGF receptor-2 (VEGFR-2) to be part of a multi-protein complex involving ZO-1, VE-cadherin and beta-catenin PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:18687691 Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by i... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18687691 assertion concerns GSK3B (P49841). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18687691 By immunoprecipitation, we discovered that GSK-3ฮฒ binding to ฮฒ-catenin was increased upon isoflavone treatment PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal t... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18772112 assertion concerns RUNX3 (Q13761). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down, chromatin immunoprecipitation assay. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:18772112 RUNX3, a gastric tumor suppressor, forms a ternary complex with beta-catenin/TCF4 and attenuates Wnt signaling activity PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:18772112 RUNX3 attenuates beta-catenin/T cell factors in intestinal t... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18772112 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:18772112 RUNX3, a gastric tumor suppressor, forms a ternary complex with beta-catenin/TCF4 and attenuates Wnt signaling activity PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:18805092 Structural insights into NEDD8 activation of cullin-RING lig... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18805092 assertion concerns BTRC (Q9Y297). The exact current interaction records recover this positive pair using enzymatic study. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:18835279 Structural basis of beta-catenin recognition by Tax-interact... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18835279 assertion concerns Tax1bp3 (Q9DBG9). The exact current interaction records recover this positive pair using x-ray crystallography, isothermal titration calorimetry. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:18936100 Dapper1 is a nucleocytoplasmic shuttling protein that negati... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:18936100 assertion concerns DACT1 (Q9NYF0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:18948590 Loss of ephrin-A5 function disrupts lens fiber cell packing ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18948590 assertion concerns CDH2 (P19022). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:18948590 by enhancing recruitment of beta-catenin to N-cadherin PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:18948590 Loss of ephrin-A5 function disrupts lens fiber cell packing ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:18948590 assertion concerns EPHA2 (P29317). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:19016843 Molecular basis of actin reorganization promoted by binding ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19016843 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using pull down. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19038973 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:19038973 CDH1 antibody precipitated beta-CATENIN PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:19166851 Kaiso is a bimodal modulator for Wnt/beta-catenin signaling. | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:19166851 assertion concerns AXIN1 (O15169). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:19167335 Large-scale structural analysis of the classical human prote... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The literal source tests PTPRC residues 622โ1238 against the beta-catenin 82โ91 phosphopeptide carrying phospho-Tyr86. This supports the phosphatase-binding class at the peptide/domain assay scope. It is distinct from the negative CD45 trapping control in PMID:12370829; neither assay should be silently substituted for the other. Proposed replacements: protein phosphatase binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:19167335 Large-scale structural analysis of the classical human prote... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19167335 assertion concerns PTPRG (P23470). The exact current interaction records recover this positive pair using phosphatase assay. The partner identity and the reported interaction support the more informative protein phosphatase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein phosphatase binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:19167335 Large-scale structural analysis of the classical human prote... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19167335 assertion concerns PTPRJ (Q12913). The exact current interaction records recover this positive pair using phosphatase assay. The partner identity and the reported interaction support the more informative protein phosphatase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein phosphatase binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:19202075 Beta-arrestin links endothelin A receptor to beta-catenin si... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19202075 assertion concerns TCF7L2 (Q9NQB0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:19303846 Disrupted in schizophrenia 1 regulates neuronal progenitor p... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19303846 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using protein kinase assay. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:19358846 The RNA aptamer disrupts protein-protein interaction between... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The positive NFKB1 interaction is retained, but the accession also represents the p105 precursor of p50. The recovered source/construct scope does not independently establish which processed product supplies DNA-binding activity in this pair. Keep the generic positive association as non-core rather than transferring a mature p50-specific class to every precursor construct. Supporting Evidence: PMID:19358846 disrupting protein-protein interaction between beta-catenin and nuclear factor-kappaB (NF-kappaB) p50 PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:19358846 The RNA aptamer disrupts protein-protein interaction between... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19358846 assertion concerns TCF7 (P36402). The exact current interaction records recover this positive pair using pull down. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:19433865 Endosomal adaptor proteins APPL1 and APPL2 are novel activat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The mixed source assertion combines APPL adaptors and HDAC partners. It supports a positive associated regulatory complex, not a single uniform histone-deacetylase or transcription-factor class for every listed partner. Preserve the complete partner set and retain this context as non-core. Supporting Evidence: PMID:19433865 The ability of Reptin to bind both ฮฒ-catenin and HDAC1 further suggested the formation of a ฮฒ-catenin-Reptin-HDAC1 complex at the promoter |
| GO:0005515 protein binding | IPI PMID:19433865 Endosomal adaptor proteins APPL1 and APPL2 are novel activat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The mixed source assertion combines APPL1 and HDAC partners. Preserve all partners and the positive associated complex as non-core; a histone-deacetylase class does not describe the complete source tuple. Supporting Evidence: PMID:19433865 The ability of Reptin to bind both ฮฒ-catenin and HDAC1 further suggested the formation of a ฮฒ-catenin-Reptin-HDAC1 complex at the promoter |
| GO:0005515 protein binding | IPI PMID:19571879 Telomerase modulates Wnt signalling by association with targ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The source reports TERT association with the beta-catenin transcriptional complex. Preserve that positive non-core context without assigning telomerase catalysis or a universal TERT-containing Wnt complex to beta-catenin. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:19805379 Chromatin protein HMGB2 regulates articular cartilage surfac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19805379 assertion concerns Lef1 (P27782). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:19805379 potentiates transcriptional activation of the Lef-1-beta-catenin complex PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:19816403 The kinase TNIK is an essential activator of Wnt target gene... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19816403 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:19816403 The kinase TNIK is an essential activator of Wnt target gene... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19816403 assertion concerns TNIK (Q9UKE5). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, pull down. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:19816403 TNIK directly binds both TCF4 and beta-catenin and phosphorylates TCF4 PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:19830702 GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/bet... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:19830702 assertion concerns CDH2 (P19022). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:19830702 GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin pool in the differentiation of SH-SY5Y cells PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:20123964 assertion concerns CDH5 (P33151). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:20123964 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:20126258 Global regulator SATB1 recruits beta-catenin and regulates T... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The original study maps SATB1โbeta-catenin binding and reports promoter-associated coactivation, with SATB1 as a sequence-specific DNA-binding regulator. This supports the Pol II transcription-factor-binding class. The 2022 and 2025 editorial notices identify figure/data-availability concerns; these limit confidence but do not retract the binding result. IVT/GST, human-cell and mouse-tissue experiments remain distinct. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:20126258 interacts with beta-catenin and recruits it to SATB1 PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:20126258 Global regulator SATB1 recruits beta-catenin and regulates T... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source reports beta-catenin association with TCF7L2 and competition with SATB1 in promoter/regulatory assays, supporting the Pol II DNA-binding transcription-factor class. Preserve the original source while acknowledging the subsequent editorial concerns and the limits of the reported constructs; no universal direct DNA-binding activity is assigned to beta-catenin. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:20126258 Competition between SATB1 and TCF affects the transcription of TCF-regulated genes upon beta-catenin signalling PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:20164195 The phospholipid-binding protein SESTD1 is a novel regulator... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:20164195 assertion concerns SESTD1 (Q86VW0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:20195357 A comprehensive resource of interacting protein regions for ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:20195357 assertion concerns AKAP12 (Q02952). The exact current interaction records recover this positive pair using display technology. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:20195357 A comprehensive resource of interacting protein regions for ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:20195357 assertion concerns BLTP1 (Q2LD37). The exact current interaction records recover this positive pair using display technology. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:20211142 An atlas of combinatorial transcriptional regulation in mous... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:20211142 assertion concerns TAX1BP3 (O14907). The exact current interaction records recover this positive pair using two hybrid array. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:20211142 An atlas of combinatorial transcriptional regulation in mous... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:20211142 assertion concerns CTNNBIP1 (Q9NSA3). The exact current interaction records recover this positive pair using two hybrid array. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:20360943 Small molecule inhibitors of Wnt/beta-catenin/lef-1 signalin... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:20360943 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:20531388 Mutant huntingtin-impaired degradation of beta-catenin cause... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:20531388 assertion concerns Axin1 (O35625). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:20531388 Mutant huntingtin-impaired degradation of beta-catenin cause... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:20531388 assertion concerns BTRC (Q9Y297). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:21103407 The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/ฮฒ-catenin... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The selected original human LS174T experiments support endogenous TCF4/beta-catenin/MLLT10/DOT1L association, with beta-catenin-dependent cofactor recruitment. The read Methods and Wnt reporter context do not provide an accession-resolving TCF4 insert or specific antibody catalog identity. They therefore preserve a positive TCF/LEF complex result without adjudicating the imported P15884/E2-2 partner. The exact source assertion remains unresolved; this is not a negative interaction judgment. Supporting Evidence: PMID:21103407 by inducing the formation of nuclear TCF4/ฮฒ-catenin complexes |
| GO:0005515 protein binding | IPI PMID:21103407 The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/ฮฒ-catenin... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21103407 assertion concerns MLLT10 (P55197). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:21103407 we identified the leukemia-associated Mllt10/Af10 and the methyltransferase Dot1l as Tcf4/ฮฒ-catenin interactors in mouse small intestinal crypts PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:21112398 Receptor tyrosine phosphatase PTPฮณ is a regulator of spinal ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21112398 assertion concerns PTPRG (P23470). The exact current interaction records recover this positive pair using phosphatase assay. The partner identity and the reported interaction support the more informative protein phosphatase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein phosphatase binding Supporting Evidence: PMID:21112398 since PTPฮณ can dephosphorylate it in vitro |
| GO:0005515 protein binding | IPI PMID:21118991 The EDD E3 ubiquitin ligase ubiquitinates and up-regulates b... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21118991 assertion concerns UBR5 (O95071). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:21118991 the E3 ubiquitin ligase identified by differential display (EDD) that also binds ฮฒ-catenin PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:21132015 Protein tyrosine kinase 7 has a conserved role in Wnt/ฮฒ-cate... | MODIFY | Summary: protein binding: refine to signaling receptor binding at the demonstrated partner and construct scope. Reason: Human PTK7 is a signaling receptor despite its inactive kinase domain. The original study maps beta-catenin association to the intracellular kinase-like region, also reports full-length PTK7 co-immunoprecipitation in transfected COS7 cells and endogenous association in human Caco2 cells. Signaling receptor binding captures the demonstrated partner class without assigning kinase activity to PTK7 or receptor agonist activity to beta-catenin; these association assays do not establish a purified binary interaction. Proposed replacements: signaling receptor binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:21242974 Methylation by protein arginine methyltransferase 1 increase... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:21242974 assertion concerns AXIN1 (O15169). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:21357690 RET modulates cell adhesion via its cleavage by caspase in s... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21357690 assertion concerns CDH2 (P19022). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:21357690 although the interaction of N-cadherin with ฮฒ-catenin was unaffected PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:21376238 Yap1 acts downstream of ฮฑ-catenin to control epidermal proli... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21376238 assertion concerns YAP1 (P46937). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:21399610 Jerky/Earthbound facilitates cell-specific Wnt/Wingless sign... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: JRK is a DNA-associated protein, but the recovered evidence does not establish the specific transcription-factor machinery role required for a narrower binding class. Retain the positive JRK association as non-core. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:21724833 Identification of PTPN23 as a novel regulator of cell invasi... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: Positive beta-catenin capture by the PTPN23 E1357A trapping domain from pervanadate-treated mammary-cell lysate is supported. Protein phosphatase binding is defensible from reported PTPN23 peptide turnover and later WT-domain FYN dephosphorylation with a catalytic-cysteine control. Earlier synthetic-substrate assays were negative, so retain explicit activity controversy and substrate/construct limits. Trapping does not itself demonstrate purified beta-catenin dephosphorylation or stable WT binding. No catalytic activity is transferred to CTNNB1. Proposed replacements: protein phosphatase binding Supporting Evidence: PMID:21724833 we identified SRC, E-cadherin, and ฮฒ-catenin as direct substrates of PTPN23 |
| GO:0005515 protein binding | IPI PMID:21741601 Targeting androgen receptor in estrogen receptor-negative br... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21741601 assertion concerns AR (P10275). The exact current interaction records recover this positive pair using confocal microscopy, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative nuclear receptor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0005515 protein binding | IPI PMID:21743491 Microsomal prostaglandin E synthase-1 promotes hepatocarcino... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The selected original human hepatocellular-carcinoma experiments show positive nuclear co-immunoprecipitation and DNA-affinity association involving beta-catenin, TCF4 and LEF1. The TCF/LEF DNA element and Wnt context are consistent with HMG-family factors, but the read Methods do not resolve the imported P15884 identity by a TCF4 clone sequence or specific reagent catalog. Retain the measured positive association while treating the precise P15884 source interpretation as unresolved. Supporting Evidence: PMID:21743491 induces the formation of EGR1-ฮฒ-catenin complex, which interacts with TCF4/LEF1 transcription factors |
| GO:0005515 protein binding | IPI PMID:21743491 Microsomal prostaglandin E synthase-1 promotes hepatocarcino... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21743491 assertion concerns EGR1 (P18146). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:21743491 induces the formation of EGR1-ฮฒ-catenin complex, which interacts with TCF4/LEF1 transcription factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:21743491 Microsomal prostaglandin E synthase-1 promotes hepatocarcino... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21743491 assertion concerns GSK3B (P49841). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:21743491 cytoplasmic ฮฒ-catenin associates in a complex with glycogen synthase kinase-3ฮฒ (GSK-3ฮฒ), Axin and APC PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:21743491 Microsomal prostaglandin E synthase-1 promotes hepatocarcino... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21743491 assertion concerns LEF1 (Q9UJU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:21743491 induces the formation of EGR1-ฮฒ-catenin complex, which interacts with TCF4/LEF1 transcription factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:21751375 Functional analysis of novel phosphorylation sites of CREB-b... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The literal CREBBP binding construct is its N-terminal region rather than the catalytic HAT domain. CREBBP is independently an acetyltransferase, so the partner-class refinement remains meaningful, but the interaction is not evidence that the tested fragment catalyzes acetylation or that beta-catenin does so. Proposed replacements: histone acetyltransferase binding Supporting Evidence: PMID:21751375 p300/CBP (CREB-binding protein) is recruited by nuclear ฮฒ-catenin to regulate a wide array of T-cell factor (TCF)-dependent gene expression |
| GO:0005515 protein binding | IPI PMID:21885566 The beta-catenin binding protein ICAT modulates androgen rec... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:21885566 assertion concerns AR (P10275). The exact current interaction records recover this positive pair using pull down, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative nuclear receptor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:21885566 ฮฒ-catenin is a cofactor of the androgen receptor (AR) and can augment AR signaling PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0005515 protein binding | IPI PMID:21885566 The beta-catenin binding protein ICAT modulates androgen rec... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:21885566 assertion concerns CTNNBIP1 (Q9NSA3). The exact current interaction records recover this positive pair using pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22014570 FoxM1 promotes ฮฒ-catenin nuclear localization and controls W... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22014570 assertion concerns FOXM1 (Q08050). The exact current interaction records recover this positive pair using confocal microscopy, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, chromatin immunoprecipitation assay. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:22014570 FoxM1 promotes ฮฒ-catenin nuclear localization and controls W... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22014570 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22056988 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:22056988 behaved similarly to WT ฮฒ-catenin in binding to APC, AXIN2, and E-cadherin PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22056988 assertion concerns SRC (P12931). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:22056988 K433 of PKM2 binds to c-Src-phosphorylated Y333 of ฮฒ-catenin PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The original study reports PKM2 association with beta-catenin. In its purified binding assay, SRC phosphorylation of beta-catenin Tyr333 permits binding, whereas unphosphorylated beta-catenin does not bind under those conditions. Retain this regulatory interaction as non-core, with no transfer of PKM catalytic activity to beta-catenin. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The source explicitly tests the PKM2 product in phosphorylation-dependent beta-catenin binding, including a catalytic mutant that retains the association. Preserve the source isoform/partner assignment and this positive non-core regulatory context; it is not evidence for beta-catenin catalysis or all PKM products. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The original source states that beta-catenin Y333F retains APC association in its specificity comparison. Preserve this positive destruction-complex interaction as non-core, separately from the PKM2-dependent transcriptional assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22056988 assertion concerns TCF7L2 (Q9NQB0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:22056988 PKM2 depletion inhibited EGF-induced interaction between ฮฒ-catenin and Myc-tagged TCF4 PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:22056988 Nuclear PKM2 regulates ฮฒ-catenin transactivation upon EGFR a... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The original source states that beta-catenin Y333F retains AXIN2 association in its specificity comparison. Preserve that positive non-core interaction; it is not evidence that beta-catenin performs the destruction complex enzymesโ reactions. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22158051 Tumor suppressor Alpha B-crystallin (CRYAB) associates with ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22158051 assertion concerns CRYAB (P02511). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22158051 Tumor suppressor Alpha B-crystallin (CRYAB) associates with ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22158051 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:22158051 Both ectopically expressed and recombinant CRYAB proteins were associated with endogenous E-cadherin and ฮฒ-catenin PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:22187462 Structural basis of coactivation of liver receptor homolog-1... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The identified partner is LRH1/NR5A2, a nuclear receptor. The recovered original structural Methods use human LRH1 residues191โ541 and beta-catenin138โ663 in bacterial expression; this establishes the receptor-class interaction. Preserve the literal O00482-1 source identifier without treating a fragment as a full-product assay. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:22187462 as the first structure of ฮฒ-catenin in complex with any nuclear receptor PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0005515 protein binding | IPI PMID:22187462 Structural basis of coactivation of liver receptor homolog-1... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The original complete abstract explicitly reports androgen-receptor association dependent on the beta-catenin LRH1-binding surface. Nuclear-receptor binding is a supported partner-class refinement. Full AR construct and functional Methods remain uninspected; do not claim that the LRH1 crystal itself contains AR or that every receptor is regulated identically. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0005515 protein binding | IPI PMID:22202456 Cdx2 controls expression of the protocadherin Mucdhl, an inh... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22202456 assertion concerns CDHR5 (Q9HBB8). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:22202456 One isoform of Mucdhl interacted with ฮฒ-catenin and inhibited its transcriptional activity PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:22234184 A molecular mechanism that links Hippo signalling to the inh... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22234184 assertion concerns YAP1 (P46937). The exact current interaction records recover this positive pair using pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:22234184 YAP and TAZ, the transcriptional co-activators in the Hippo pathway, suppress Wnt signalling without suppressing the stability of ฮฒ-catenin but through preventing its nuclear translocation PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:22234184 A molecular mechanism that links Hippo signalling to the inh... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22234184 assertion concerns WWTR1 (Q9GZV5). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:22234184 YAP and TAZ, the transcriptional co-activators in the Hippo pathway, suppress Wnt signalling without suppressing the stability of ฮฒ-catenin but through preventing its nuclear translocation PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:22261717 Nuclear IGF1R is a transcriptional co-activator of LEF1/TCF. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22261717 assertion concerns IGF1R (P08069). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:22470507 Oncogenic function of DACT1 in colon cancer through the regu... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22470507 assertion concerns DACT1 (Q9NYF0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22662192 IQGAP1 interacts with components of the slit diaphragm compl... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22662192 assertion concerns IQGAP1 (P46940). The exact current interaction records recover this positive pair using confocal microscopy, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22682247 Wnt signaling through inhibition of ฮฒ-catenin degradation in... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22682247 assertion concerns AXIN1 (O15169). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22682247 Wnt signaling through inhibition of ฮฒ-catenin degradation in... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22682247 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22682247 Wnt signaling through inhibition of ฮฒ-catenin degradation in... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22682247 assertion concerns FBXW11 (Q9UKB1). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:22699938 Kindlin 2 forms a transcriptional complex with ฮฒ-catenin and... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The complete accessible abstract reports a positive kindlin-2/beta-catenin/TCF4 complex. Five matched MINT records include cellular co-immunoprecipitation and an in-vitro GST-TCF4 fragment spanning residues 1-53. This fragment is consistent with the historical N-terminal beta-catenin-binding region of TCF7L2, but the operative full Methods and insert sequence were not recovered. Canonical P15884 ROGIDs authenticate the curated participant assignment, not the assayed fragment identity. Preserve all positive fields and use UNDECIDED for this unresolved accession-specific assertion. Supporting Evidence: PMID:22699938 Kindlin 2 forms a tripartite complex with ฮฒ-catenin and TCF4 |
| GO:0005515 protein binding | IPI PMID:22699938 Kindlin 2 forms a transcriptional complex with ฮฒ-catenin and... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:22699938 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:22699938 Kindlin 2 forms a transcriptional complex with ฮฒ-catenin and... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22699938 assertion concerns FERMT2 (Q96AC1). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, fluorescence microscopy, pull down. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22728435 Identification of paxillin domains interacting with ฮฒ-cateni... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22728435 assertion concerns PXN (P49023). The exact current interaction records recover this positive pair using pull down, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:22773187 Dual functions of DP1 promote biphasic Wnt-on and Wnt-off st... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:22773187 assertion concerns AXIN1 (O15169). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:23084749 Regulation of CD133 by HDAC6 promotes ฮฒ-catenin signaling to... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The source explicitly reports a CD133โHDAC6โbeta-catenin ternary association. Keep this positive interaction as non-core. HDAC6โs nonhistone deacetylation context and official caution do not justify calling the observed relationship histone-deacetylase binding solely from its historical name. Supporting Evidence: PMID:23084749 CD133, HDAC6, and the central molecule of the canonical Wnt signaling pathway, ฮฒ-catenin, can physically associate as a ternary complex |
| GO:0005515 protein binding | IPI PMID:23124878 ฮฒ-catenin regulates parathyroid hormone/parathyroid hormone-... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The literal two-hybrid record tests the PTH1R cytoplasmic tail (residues 463โ593, with reported mutations) against beta-catenin. PTH1R is a signaling receptor, supporting signaling receptor binding at that construct scope. The binding term does not require beta-catenin to be its extracellular activating ligand. Proposed replacements: signaling receptor binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:23136403 Mutations in the area composita protein ฮฑT-catenin are assoc... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23136403 assertion concerns CTNNA3 (Q9UI47-1). The exact current interaction records recover this positive pair using two hybrid, anti tag coimmunoprecipitation, confocal microscopy, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:23245941 ฮฒ-Catenin-driven cancers require a YAP1 transcriptional comp... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23245941 assertion concerns YAP1 (P46937). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:23245941 ฮฒ-Catenin-driven cancers require a YAP1 transcriptional comp... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23245941 assertion concerns YAP1 (P46937-3). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:23245942 Role of TAZ as mediator of Wnt signaling. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23245942 assertion concerns Wwtr1 (Q9EPK5). The exact current interaction records recover this positive pair using pull down, anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:23245942 TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/ฮฒ-catenin cascade PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:23245942 Role of TAZ as mediator of Wnt signaling. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23245942 assertion concerns WWTR1 (Q9GZV5). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:23245942 TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/ฮฒ-catenin cascade PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:23273993 Intestinal tumorigenesis initiated by dedifferentiation and ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23273993 assertion concerns RELA (Q04206). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:23273993 Intestinal tumorigenesis initiated by dedifferentiation and ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23273993 assertion concerns CREBBP (Q92793). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative histone acetyltransferase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: histone acetyltransferase binding Supporting Evidence: PMID:21751375 p300/CBP (CREB-binding protein) is recruited by nuclear ฮฒ-catenin to regulate a wide array of T-cell factor (TCF)-dependent gene expression |
| GO:0005515 protein binding | IPI PMID:23602568 The protein interaction landscape of the human CMGC kinase g... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:23602568 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using tandem affinity purification. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:23736261 Autolysosomal ฮฒ-catenin degradation regulates Wnt-autophagy-... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:23736261 assertion concerns MAP1LC3B (Q9GZQ8). The exact current interaction records recover this positive pair using pull down, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:24072822 Mucus enhances gut homeostasis and oral tolerance by deliver... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24072822 assertion concerns RELA (Q04206). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:24072822 enhanced nuclear ฮฒ-catenin interaction with NF-ฮบB p65 PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:24424122 Rescue of wild-type E-cadherin expression from nonsense-muta... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24424122 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using proximity ligation assay. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:24509793 ฮฑ-catenin acts as a tumour suppressor in E-cadherin-negative... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24509793 assertion concerns CTNNA1 (P35221). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:24550280 Large-scale interaction profiling of PDZ domains through pro... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24550280 assertion concerns SCRIB (Q14160). The exact current interaction records recover this positive pair using phage display, fluorescence microscopy. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:24561623 MicroRNA-146a directs the symmetric division of Snail-domina... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:24561623 assertion concerns NUMB (P49757). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:24561623 MicroRNA-146a directs the symmetric division of Snail-domina... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:24561623 assertion concerns NUMB (P49757-3). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:24561623 MicroRNA-146a directs the symmetric division of Snail-domina... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24561623 assertion concerns BTRC (Q9Y297). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:24650032 MicroRNA-566 activates EGFR signaling and its inhibition sen... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24650032 assertion concerns HIF1A (Q16665). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:24960609 The Wnt receptor Ryk reduces neuronal and cell survival capa... | MODIFY | Summary: protein binding: refine to signaling receptor binding at the demonstrated partner and construct scope. Reason: The source tests mouse Ryk constructs in human 293T cells: wild-type and uncleavable full-length Ryk co-immunoprecipitate endogenous beta-catenin, while the intracellular cleavage product also associates separately. Ryk is a Wnt signaling receptor with an inactive kinase-like domain. Signaling receptor binding captures the full-length receptor association without implying kinase binding, beta-catenin agonism, or equivalence between intact receptor and released intracellular-domain functions. Proposed replacements: signaling receptor binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:24976009 YAP/TAZ incorporation in the ฮฒ-catenin destruction complex o... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:24976009 assertion concerns AXIN1 (O15169). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:24976009 YAP/TAZ incorporation in the ฮฒ-catenin destruction complex o... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:24976009 assertion concerns YAP1 (P46937). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:24976009 YAP and TAZ are integral components of the ฮฒ-catenin destruction complex PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:25062958 Bidirectional cross-regulation between the endothelial nitri... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:25062958 assertion concerns NOS3 (P29474). The exact current interaction records recover this positive pair using proximity ligation assay, anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source-specific positive ACTN4 proximity/interaction record and its official alpha-actinin identity support alpha-actinin binding. The assay does not prove an isolated binary contact or transfer actin-crosslinking activity to beta-catenin. Proposed replacements: alpha-actinin binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25241761 assertion concerns FGFR1 (P11362). The exact current interaction records recover this positive pair using proximity ligation assay. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: Retain the positive NFKB1 association at the assayed source scope. Because the official accession covers the p105 precursor as well as its processed p50 product, the recovered construct information does not securely warrant the narrower mature DNA-binding-factor class for this pair. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:25241761 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using proximity ligation assay. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25241761 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using proximity ligation assay. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:25241761 assertion concerns PARD3 (Q8TEW0). The exact current interaction records recover this positive pair using proximity ligation assay. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25266658 The ubiquitin ligase RNF220 enhances canonical Wnt signaling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25266658 assertion concerns RNF220 (Q5VTB9). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:25266658 we identify RNF220, a RING domain E3 ubiquitin ligase, as a new regulator of ฮฒ-catenin PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:25344754 ASPP2 controls epithelial plasticity and inhibits metastasis... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25344754 assertion concerns CDH1 (P12830). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:25344754 by forming an ASPP2-ฮฒ-catenin-E-cadherin ternary complex PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:25344754 ASPP2 controls epithelial plasticity and inhibits metastasis... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:25344754 assertion concerns TP53BP2 (Q13625). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25402006 In silico prediction of physical protein interactions and ch... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The literal experimental IntAct record EBI-10827628 / IM-24266-15 identifies beta-catenin and P15884 in an in-vitro GST pull-down with a radiolabeled partner (Supplementary Figure 2B and Supplementary Data File 4), with a positive record and independently reproduced canonical participant ROGIDs. This is an experimental validation record, not merely a computational prediction from the screen. Official P15884 is itself a sequence-specific RNA polymerase II transcription factor, so GO:0061629 is the more informative binding class. Retain the measured pair with explicit curator deference: the complete abstract and curated assay record were read, but the original supplementary image, insert and full Methods were not. No TCF7L2 quotation is used as proof of this P15884 pair. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25609649 Proteomic analyses reveal distinct chromatin-associated and ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25609649 assertion concerns FBXW11 (Q9UKB1). The exact current interaction records recover this positive pair using tandem affinity purification. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:25678599 The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptio... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25678599 assertion concerns TCF7 (P36402). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:25678599 WWOX inhibits the ฮฒ-catenin-TCF1 interaction PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:25678599 The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptio... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25678599 assertion concerns Bcl9l (Q67FY2). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:25678599 The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the ฮฒ-Catenin Coactivator BCL9-2 in Breast Cancer Cells PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:25753001 A Protein Interaction between ฮฒ-Catenin and Dnmt1 Regulates ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:25753001 assertion concerns DNMT1 (P26358). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25807484 Loss of ฮด-catenin function in severe autism. | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The available autism-focused source does not resolve the exact CTNND2โbeta-catenin assay or construct, and no matching current literal interaction was recovered. Preserve the positive curated assertion as unresolved rather than rejecting it from the paperโs title or substituting another alpha/p120-catenin relationship. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25873176 TGIF governs a feed-forward network that empowers Wnt signal... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:25873176 assertion concerns BTRC (Q9Y297). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:26496610 assertion concerns AXIN1 (O15169). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:26496610 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:26496610 assertion concerns CTNNA1 (P35221). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:26496610 assertion concerns AMER1 (Q5JTC6). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:26893351 The transcription factor SOX6 contributes to the development... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:26893351 assertion concerns Sox6 (P40645). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:26893351 SOX6 interacts with ฮฒ-catenin in adipocytes PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:27173435 An organelle-specific protein landscape identifies novel dis... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:27173435 assertion concerns NHERF2 (Q15599). The exact current interaction records recover this positive pair using tandem affinity purification. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:27601169 Vitamin D receptor is a novel transcriptional regulator for ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:27601169 assertion concerns VDR (P11473). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative nuclear receptor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:27601169 Physical interactions among VDR, Axin1, and ฮฒ-catenin were tested by immunoprecipitation PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor |
| GO:0005515 protein binding | IPI PMID:27601169 Vitamin D receptor is a novel transcriptional regulator for ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:27601169 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:27601169 there were interactions between ฮฒ-catenin and GSK3 ฮฒ PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:28051067 VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hip... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The selected original Methods and Results specify TCF4 fragments 8-54 for beta-catenin binding and 326-411 for DNA binding, and a larger 8-411 construct with an internal deletion. This HMG TCF7L2-like architecture differs from the C-terminal bHLH domain of canonical P15884/E2-2. The positive beta-catenin/TCF4 assays remain valid, but they do not establish the literal imported P15884 partner. Preserve that machine source and record the unresolved accession/construct mismatch; do not invent an exact historical isoform sequence or infer absence of P15884 binding in other contexts. Supporting Evidence: PMID:28051067 ฮฒ-catenin translocates into the nucleus, where it interacts with the transcription factors TCF4/LEF1 to regulate the expression of the target genes |
| GO:0005515 protein binding | IPI PMID:28051089 Cadherin 26 is an alpha integrin-binding epithelial receptor... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The original CDH26 study reports association with beta-catenin and alpha/p120-catenins. The complete assertion contains CDH26, CTNNA1 and CTNND1, so cadherin binding is not an adequate classification for every listed partner. Retain the positive mixed junctional association as non-core without rewriting its partner set. Supporting Evidence: PMID:28051089 interaction with catenin family members (alpha, beta, and p120) PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:28514442 assertion concerns CDH5 (P33151). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:28514442 assertion concerns CTNNBIP1 (Q9NSA3). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:28829046 Twa1/Gid8 is a ฮฒ-catenin nuclear retention factor in Wnt sig... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:28829046 assertion concerns AXIN1 (O15169). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:28829046 Twa1/Gid8 is a ฮฒ-catenin nuclear retention factor in Wnt sig... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:28829046 assertion concerns TCF7L2 (Q9NQB0). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:28829046 Twa1/Gid8 is a ฮฒ-catenin nuclear retention factor in Wnt sig... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:28829046 assertion concerns GID8 (Q9NWU2). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:29361949 miR-182-5p promotes hepatocellular carcinoma progression by ... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The selected original HCC Results and IntAct record support positive endogenous beta-catenin/TCF4 co-immunoprecipitation in Figure 6b. The read Methods describe the relevant cellular experiments but do not identify a TCF4 insert or an accession-resolving antibody reagent. Wnt-family context cannot by itself validate the imported P15884/E2-2 identity. Preserve the positive association and its source tuple, with the exact partner assertion unresolved. Supporting Evidence: PMID:29361949 enhancing the interaction between ฮฒ-catenin and TCF4 |
| GO:0005515 protein binding | IPI PMID:29367600 Transmembrane protein 170B is a novel breast tumorigenesis s... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:29367600 assertion concerns TMEM170B (Q5T4T1). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:29374064 Forkhead Box F2 Suppresses Gastric Cancer through a Novel FO... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:29374064 assertion concerns IRF2BPL (Q9H1B7). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative ubiquitin protein ligase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: ubiquitin protein ligase binding Supporting Evidence: PMID:29374064 IRF2BPL in turn interacted with ฮฒ-catenin, increasing its ubiquitination and degradation PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:29568061 An AP-MS- and BioID-compatible MAC-tag enables comprehensive... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:29568061 assertion concerns GSK3B (P49841). The exact current interaction records recover this positive pair using proximity-dependent biotin identification. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:29739711 SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Sign... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:29739711 assertion concerns SOX30 (O94993). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:29739711 interacting with ฮฒ-catenin to compete with TCF for binding to ฮฒ-catenin PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:29774127 PAF1 complex interactions with SETDB1 mediate promoter H3K9 ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:29774127 assertion concerns CDC73 (Q6P1J9). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:29774127 a trio of tyrosine residues on CDC73 that regulate its interaction with ฮฒ-catenin PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:29910125 DSG2 Is a Functional Cell Surface Marker for Identification ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:29910125 assertion concerns DSG2 (Q14126). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:30833792 A protein-interaction network of interferon-stimulated genes... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:30833792 assertion concerns TCF7L2 (Q9NQB0). The exact current interaction records recover this positive pair using pull down. The partner identity and the reported interaction support the more informative RNA polymerase II-specific DNA-binding transcription factor binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: RNA polymerase II-specific DNA-binding transcription factor binding Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0005515 protein binding | IPI PMID:30992345 Connexin 43 maintains tissue polarity and regulates mitotic ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:30992345 assertion concerns GJA1 (P17302). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:31073040 LMBR1L regulates lymphopoiesis through Wnt/ฮฒ-catenin signali... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:31073040 assertion concerns LMBR1L (Q6UX01). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:32707033 assertion concerns MAST1 (Q9Y2H9). The exact current interaction records recover this positive pair using pull down. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns DMWD (G5E9A7). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns HIP1 (O00291). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns TOR1A (O14656-2). The exact current interaction records recover this positive pair using two hybrid array, validated two hybrid, two hybrid pooling approach. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns PRPF40A (O75400-2). The exact current interaction records recover this positive pair using two hybrid array, validated two hybrid, two hybrid pooling approach. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns A2M (P01023). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns CRYAB (P02511). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns GAPDH (P04406). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns HSP90AA1 (P07900). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns LAMP2 (P13473-2). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns GFAP (P14136). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns NDUFV2 (P19404). The exact current interaction records recover this positive pair using two hybrid pooling approach, validated two hybrid, two hybrid array. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns BDNF (P23560-2). The exact current interaction records recover this positive pair using two hybrid pooling approach, two hybrid array, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns CBS (P35520). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns HTT (P42858). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns MECP2 (P51608). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns CASP6 (P55212). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns RAN (P62826). The exact current interaction records recover this positive pair using two hybrid array, validated two hybrid, two hybrid pooling approach. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns LRP8 (Q14114-3). The exact current interaction records recover this positive pair using two hybrid pooling approach, validated two hybrid, two hybrid array. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns SPRED1 (Q7Z699). The exact current interaction records recover this positive pair using validated two hybrid, two hybrid pooling approach, two hybrid array. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns JPH3 (Q8WXH2). The exact current interaction records recover this positive pair using two hybrid array, validated two hybrid, two hybrid pooling approach. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:32814053 assertion concerns FGF14 (Q92915-2). The exact current interaction records recover this positive pair using two hybrid array, two hybrid pooling approach, validated two hybrid. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:33961781 assertion concerns TAX1BP3 (O14907). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative PDZ domain binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:33961781 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:33961781 assertion concerns CDH2 (P19022). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:33961781 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:33961781 assertion concerns CTNNA2 (P26232). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:33961781 assertion concerns CDH5 (P33151). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:33961781 assertion concerns CTNNA1 (P35221). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:33961781 assertion concerns CTNNBIP1 (Q9NSA3). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33964137 Biallelic mutations in RNF220 cause laminopathies featuring ... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The exact RNF220โbeta-catenin record in this source was not recovered. Earlier RNF220 evidence supports a biologically plausible relationship, but it does not authenticate this separate source assay. Preserve the assertion as unresolved, without asserting nonbinding or using another paper to claim the missing record was read. Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0005515 protein binding | IPI PMID:34591612 A protein interaction landscape of breast cancer. | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:34591612 assertion concerns CDH1 (P12830). The exact current interaction records recover this positive pair using anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The OpenCell source is a genuine endogenously tagged-cell interaction/localization survey, but its exact beta-catenin partner table entry was not recovered in the accessible material. Independent knowledge of the same proteins does not verify this specific source record. Preserve the curated positive assertion and its partners as unresolved; do not infer that the association is false. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The OpenCell source is a genuine endogenously tagged-cell interaction/localization survey, but its exact beta-catenin partner table entry was not recovered in the accessible material. Independent knowledge of the same proteins does not verify this specific source record. Preserve the curated positive assertion and its partners as unresolved; do not infer that the association is false. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The OpenCell source is a genuine endogenously tagged-cell interaction/localization survey, but its exact beta-catenin partner table entry was not recovered in the accessible material. Independent knowledge of the same proteins does not verify this specific source record. Preserve the curated positive assertion and its partners as unresolved; do not infer that the association is false. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The OpenCell source is a genuine endogenously tagged-cell interaction/localization survey, but its exact beta-catenin partner table entry was not recovered in the accessible material. Independent knowledge of the same proteins does not verify this specific source record. Preserve the curated positive assertion and its partners as unresolved; do not infer that the association is false. Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The OpenCell source is a genuine endogenously tagged-cell interaction/localization survey, but its exact beta-catenin partner table entry was not recovered in the accessible material. Independent knowledge of the same proteins does not verify this specific source record. Preserve the curated positive assertion and its partners as unresolved; do not infer that the association is false. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:35384245 assertion concerns FGFR1 (P11362). The exact current interaction records recover this positive pair using proximity-dependent biotin identification. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged GRID2IP PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged TAX1BP3 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: TX1BP3 at Dataset 1 row 434 (normalized BI 0.93286813, 2 measurement(s), composite pKd 5.98851238). These support the more informative PDZ-domain-binding term. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged MPDZ PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged DLG4 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged APBA1 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged TJP1 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged DLG1 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged IL16 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged SCRIB PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: SCRIB_1 at Dataset 1 row 2384 (normalized BI 0.53235356, 1 measurement(s), composite pKd 4.85568958); SCRIB_3 at Dataset 1 row 2544 (normalized BI 0.51534557, 1 measurement(s), composite pKd 4.82421571); SCRIB_2 at Dataset 1 row 16166 (normalized BI 0.06203321, 2 measurement(s), composite pKd 3.57119273). These support the more informative PDZ-domain-binding term. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged NHERF2 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: NHERF2_2 at Dataset 1 row 2316 (normalized BI 0.54134916, 2 measurement(s), composite pKd 4.87238809). These support the more informative PDZ-domain-binding term. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged DLG2 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged PDZK1 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: NHERF3_1 at Dataset 1 row 14601 (normalized BI 0.07414263, 2 measurement(s), composite pKd 3.65546651). These support the more informative PDZ-domain-binding term. The separately preserved current database records for NHERF3_3, NHERF3_4 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged ARHGAP21 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: ARHGAP21 at Dataset 1 row 2292 (normalized BI 0.54494291, 1 measurement(s), composite pKd 4.87907237). These support the more informative PDZ-domain-binding term. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged FRMPD2 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged MAGI2 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: MAGI2_6 at Dataset 1 row 1381 (normalized BI 0.68313486, 2 measurement(s), composite pKd 5.14986519). These support the more informative PDZ-domain-binding term. The separately preserved current database records for MAGI2_2, MAGI2_3, MAGI2_4, MAGI2_5 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged NHERF4 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: NHERF4_4 at Dataset 1 row 8941 (normalized BI 0.16026371, 2 measurement(s), composite pKd 4.04116894). These support the more informative PDZ-domain-binding term. The separately preserved current database records for NHERF4_2 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged LNX2 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged PATJ PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: Inadl_6 at Dataset 1 row 7790 (normalized BI 0.19, 2 measurement(s), composite pKd 4.13431978); Inadl_3 at Dataset 1 row 13849 (normalized BI 0.08140542, 1 measurement(s), composite pKd 3.70018527). These support the more informative PDZ-domain-binding term. The separately preserved current database records for Inadl_1, Inadl_10, Inadl_2, Inadl_4, Inadl_5, Inadl_8, Inadl_9 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged LNX1 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: LNX1_1 at Dataset 1 row 18319 (normalized BI 0.05004825, 2 measurement(s), composite pKd 3.47127204). These support the more informative PDZ-domain-binding term. The separately preserved current database records for LNX1_2, LNX1_3 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The LNX1 PDZ1 value is very close to the authorsโ BI 0.05 threshold, so its limited precision and lack of cellular validation are explicit. The workbook reports two measurements and no standard deviation; the value is retained at the authorsโ stated detection threshold, not treated as robust physiological binding. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged PARD3 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged DLG3 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged MAGI1 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged APBA2 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged GRIP2 PDZ domains by holdup, rather than intact cellular complexes. The literal positive IntAct records are recoverable, but all matching original workbook measurements are below the authorsโ quantification threshold (composite pKd recorded as zero; normalized BI below 0.05). Their positive/nonnegative curation and the underlying quantitative result therefore remain unresolved. The paper explicitly states that below-threshold pairs are not established noninteractions. Preserve the source assertion and its genuine database records, but do not infer a validated positive PDZ contact, remove the biological interaction, or add a NOT qualifier from these censored measurements. Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged WHRN PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: DFNB31_1 at Dataset 1 row 6226 (normalized BI 0.24668054, 1 measurement(s), composite pKd 4.28436772). These support the more informative PDZ-domain-binding term. The separately preserved current database records for DFNB31_2, DFNB31_3 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged MAST1 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: MAST1 at Dataset 1 row 2530 (normalized BI 0.51762156, 1 measurement(s), composite pKd 4.82842195). These support the more informative PDZ-domain-binding term. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The source tests the human beta-catenin C-terminal peptide 772โ781 (NQLAWFDTDL) against isolated tagged GRIP1 PDZ domains by holdup, rather than intact cellular complexes. The original workbook supplies quantified positive PDZ contacts: GRIP1_7 at Dataset 1 row 15083 (normalized BI 0.0700938, 2 measurement(s), composite pKd 3.62878593). These support the more informative PDZ-domain-binding term. The separately preserved current database records for GRIP1_2, GRIP1_3, GRIP1_4, GRIP1_5 map to below-quantification values and remain a source-reconciliation issue; the positive same-gene measurement is not a repair of those records. The affinity conversion uses the studyโs average 18 ยตM peptide concentration; no competitive-FP measurement is reported for these pairs. No full-length physiological interaction or partner catalytic activity is inferred. Proposed replacements: PDZ domain binding Supporting Evidence: PMID:36115835 both containing PBMs that detectably bound to PDZs in our quantified interactome PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:36950384 Protein interaction studies in human induced neurons indicat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:36950384 assertion concerns CDH2 (P19022). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:36950384 Protein interaction studies in human induced neurons indicat... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:36950384 assertion concerns APC (P25054). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:36950384 Protein interaction studies in human induced neurons indicat... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:36950384 assertion concerns CTNNA2 (P26232). The exact current interaction records recover this positive pair using anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative alpha-catenin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:36959122 YAP and ฮฒ-catenin cooperate to drive H. pylori-induced gastr... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:36959122 assertion concerns YAP1 (P46937). The exact current interaction records recover this positive pair using fluorescence microscopy, anti bait coimmunoprecipitation. The partner identity and the reported interaction support the more informative transcription coregulator binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: transcription coregulator binding Supporting Evidence: PMID:17052462 Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus |
| GO:0005515 protein binding | IPI PMID:39232006 Proximity interactome of lymphatic VE-cadherin reveals mecha... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:39232006 assertion concerns CDH5 (P33151). The exact current interaction records recover this positive pair using proximity-dependent biotin identification, anti tag coimmunoprecipitation. The partner identity and the reported interaction support the more informative cadherin binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: cadherin binding Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: This source-specific TAX1BP3 interaction could not be adjudicated from the recovered article/table scope. Independent PDZ binding in other studies remains positive, but does not verify this exact current screen assertion. Preserve the source object and mark its assessment unresolved. Supporting Evidence: PMID:17242191 such as the one between the ฮฒ-catenin PDZ motif and the PDZ2 domain |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | UNDECIDED | Summary: protein binding: the specific source or functional scope remains unresolved. Reason: This source-specific CTNNBIP1 interaction could not be adjudicated from the recovered article/table scope. Independent ICAT binding is well established, but it does not verify this exact current screen record. Preserve the source assertion without an experimental rejection. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:7890674 The APC protein and E-cadherin form similar but independent ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The complete original abstract reports direct APCโbeta-catenin binding using purified proteins and yeast two-hybrid experiments. This supported interaction should be retained under the standing generic-binding instruction. Complex membership elsewhere does not invalidate this distinct source tuple; no more specific APC-binding class is established in the accessible evidence. Full Methods remain unavailable. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:8638126 assertion concerns APC (P25054). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:8638126 assertion concerns GSK3B (P49841). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein kinase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein kinase binding Supporting Evidence: PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0005515 protein binding | IPI PMID:8663237 Association of human protein-tyrosine phosphatase kappa with... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The PMID:8663237 assertion concerns PTPRK (Q15262). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. The partner identity and the reported interaction support the more informative protein phosphatase binding term. This class describes the bound partner, not catalytic or transcriptional activity transferred to beta-catenin; fragment and cell-context limits remain those of the source. Proposed replacements: protein phosphatase binding Supporting Evidence: PMID:8663237 we demonstrate specific complex formation between endogenous hPTPkappa and beta- and gamma-catenin/plakoglobin |
| GO:0005515 protein binding | IPI PMID:9264463 A specific domain in alpha-catenin mediates binding to beta-... | MODIFY | Summary: protein binding: refine the term at the demonstrated source scope. Reason: The actual partner is mouse alpha-catenin P26231. The original abstract reports recombinant alpha-catenin deletion and mutation assays that identify a beta-catenin-binding segment. Alpha-catenin binding is the direct, informative replacement. The abstract does not establish all reagent species or a full native force-bearing linkage, so retain the literal partner species and the Methods access limit. Proposed replacements: alpha-catenin binding Supporting Evidence: PMID:9264463 Here we have now identified the reciprocal complementary binding site in alpha-catenin which mediates its interaction with beta-catenin and plakoglobin PMID:7890674 although the amino-terminal half independently binds alpha-catenin |
| GO:0005515 protein binding | IPI PMID:9601641 Downregulation of beta-catenin by human Axin and its associa... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:9601641 assertion concerns AXIN1 (O15169). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:9632714 The presenilin 1 protein is a component of a high molecular ... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:9632714 assertion concerns PSEN1 (P49768). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:9707618 A novel frizzled gene identified in human esophageal carcino... | KEEP AS NON CORE | Summary: protein binding: retain the positive contextual association or function. Reason: The PMID:9707618 assertion concerns APC (P25054). The supporting publication and the curated IPI assertion are evaluated at their reported association scope; absence from the current interaction download is not evidence of nonbinding. Retain the supported association as non-core. The available partner/construct evidence does not justify a more informative uniform molecular-function replacement; this does not imply an interaction is false or a native binary contact was demonstrated. Supporting Evidence: |
| GO:0005634 nucleus | EXP PMID:21118991 The EDD E3 ubiquitin ligase ubiquitinates and up-regulates b... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | EXP PMID:25183871 Simplet/Fam53b is required for Wnt signal transduction by re... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | EXP PMID:30714168 F-box protein FBXO16 functions as a tumor suppressor by atte... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | EXP PMID:31801859 ฮฒ-Catenin Is Required for the cGAS/STING Signaling Pathway b... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. IBA from PAINT node PTN001153077 (beta-catenin/Armadillo family); human CTNNB1 among the sources reflects its own experimental support, as expected. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 46 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00006943 SUPPORTS TRANSFER Resolved to Q10953; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-991207-22 SUPPORTS TRANSFER Resolved to Q9PVF7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-980526-362 SUPPORTS TRANSFER Resolved to F1QGH7; 7 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 18 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P26233 SUPPORTS TRANSFER Resolved to P26233; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. RGD:70487 SUPPORTS TRANSFER Resolved to Q9WU82; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00000238 SUPPORTS TRANSFER Resolved to Q18825; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-040426-2575 SUPPORTS TRANSFER Resolved to Q8JID2; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:B6V8E6 SUPPORTS TRANSFER Resolved to B6V8E6; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:10980594 Secreted Frizzled-related proteins inhibit motility and prom... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:15040835 Cooperation between TGF-beta and Wnt pathways during chondro... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:16858403 The inner nuclear membrane protein emerin regulates beta-cat... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:18756595 Prognostic significance of BMP and activin membrane-bound in... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:18787224 Constitutive activation of the Wnt canonical pathway in mant... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:19095296 SFRP1 and SFRP2 suppress the transformation and invasion abi... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:19187541 Issues associated with assessing nuclear localization of N-t... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: The original antibody-specificity study distinguishes a cross-reacting nuclear 8E7 antigen from genuine beta-catenin using deficient cells and additional antibodies. Its controlled HEK293T lithium response and SW480 E-cadherin-reexpression experiments retain positive nuclear/cytosolic redistribution and Wnt-context evidence. Accept the biological assertion without treating every 8E7-stained nucleus as beta-catenin or treating the entire study as a negative localization result. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:28829046 Twa1/Gid8 is a ฮฒ-catenin nuclear retention factor in Wnt sig... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:29367600 Transmembrane protein 170B is a novel breast tumorigenesis s... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:29739711 SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Sign... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:29910125 DSG2 Is a Functional Cell Surface Marker for Identification ... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IDA PMID:9707618 A novel frizzled gene identified in human esophageal carcino... | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: nucleus: supported at the stated source and biological scope. Reason: Stabilized beta-catenin enters the nucleus and coactivates TCF/LEF; nuclear localization is central to its signalling role. The current donor audit recovers Q02248: 46 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244583, 417244618, 417244619, 417244620 and further distinct loci/contexts; references PMID:30659184, PMID:11731231, PMID:11731265. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-201669 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-201669, Beta-catenin translocates to the nucleus, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-201712 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-201712, Beta-catenin:TCF associates with BCL9 and PYGO, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3134883 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3134883, Beta-catenin enhances association of IRF3 with CBP/p300 , contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3134914 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3134914, Beta-catenin migrates to the nucleus, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3299569 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3299569, Beta-catenin displaces TLE:HDAC1 from TCF/LEF, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3322422 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3322422, Beta-catenin recruits SMARCA4, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3322424 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3322424, Beta-catenin recruits CDC73 and LEO1, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3322427 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3322427, Beta-catenin recruits CBP/p300, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3361751 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3361751, beta-catenin is replaced by repression complexes at the promoter, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3364014 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3364014, Recruitment of MLL2 methyltransferase complex, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3364026 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3364026, MLL2 complex trimethylates H3K4 at the MYC gene, contains the P35222 entity through catalystActivity membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3364042 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3364042, APC promotes disassembly of beta-catenin transactivation complex, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3451153 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3451153, Beta-catenin recruits TRRAP/KAT5 HAT components, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769383 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3769383, CBY1 binds beta-catenin, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769391 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3769391, XPO1 binds the beta-catenin:CBY complex, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769392 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3769392, YWHAZ and XPO1 mediate the nuclear export of beta-catenin, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769393 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3769393, YWHAZ binds p-CBY:CTNNB1, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3769394 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3769394, AKT phosphorylates CBY1, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-3772430 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-3772430, CTNNBIP1 binds beta-catenin, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4411351 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-4411351, TCF/LEF:CTNNB1 bind the AXIN2 gene, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4411367 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-4411367, TCF7L1/TCF7L2/LEF1:CTNNB1 bind the MYC gene, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4411383 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-4411383, NLK phosphorylates TCF/LEF, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5368580 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-5368580, CHD8 binds beta-catenin to negatively regulate WNT-dependent gene expression, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5626938 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-5626938, Beta-catenin binds SOX proteins, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-5665608 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-5665608, TCF:Beta-catenin binds SOX proteins, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8853965 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-8853965, VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8944362 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-8944362, TCF/LEF:CTNNB1 bind canonical WNT target promoters, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8951428 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-8951428, RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7), contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-8951442 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-8951442, CTNNB1:TCF7L2,LEF1 binds the CCND1 gene promoter, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9824598 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-9824598, LEF1, CTNNB1 and MITF-M bind the MITF promoter, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9825848 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-9825848, MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9858646 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-9858646, TCF/LEF:CTNNB1 binds the CCND1 gene, contains the P35222 entity through input, output, regulatedBy membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9858647 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-9858647, HINT1, HDAC1, and SIN3A bind CTNNB1 at the CCND1 promoter, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9909632 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-HSA-9909632, CTNNB1 binding to CD274 gene, contains the P35222 entity through input, output membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005654 nucleoplasm | TAS Reactome:R-NUL-3451144 | ACCEPT | Summary: nucleoplasm: supported at the stated source and biological scope. Reason: The curated event R-NUL-3451144, KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4, contains the P35222 entity through catalystActivity membership paths. This supports the recorded nucleoplasm context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005667 transcription regulator complex | IDA PMID:11751639 Chromatin-specific regulation of LEF-1-beta-catenin transcri... | MODIFY | Summary: transcription regulator complex: refine the term at the demonstrated source scope. Reason: The source directly reconstitutes beta-catenin with LEF1 on chromatin. The current beta-catenin-TCF complex definition explicitly includes LEF-family factors and cites this source, and its is_a closure includes transcription regulator complex. This is a specific complex refinement; it does not claim the paper assayed BCL9/Pygopus. A separate existing annotation with another source is not an identical source tuple. Proposed replacements: beta-catenin-TCF complex Supporting Evidence: PMID:11751639 recombinant beta-catenin strongly enhances binding and transactivation by LEF-1 on chromatin templates in vitro |
| GO:0005667 transcription regulator complex | IEA GO_REF:0000107 | ACCEPT | Summary: transcription regulator complex: supported at the stated source and biological scope. Reason: Beta-catenin forms complexes with LEF/TCF, BCL9-Pygopus and CBP/p300 on target genes. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 5 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244828, 417244829, 417244830, 417244831 and further distinct loci/contexts; references PMID:12464179, PMID:12861022, PMID:16678101. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:11751639 recombinant beta-catenin strongly enhances binding and transactivation by LEF-1 on chromatin templates in vitro |
| GO:0005737 cytoplasm | EXP PMID:25183871 Simplet/Fam53b is required for Wnt signal transduction by re... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | EXP PMID:31801859 ฮฒ-Catenin Is Required for the cGAS/STING Signaling Pathway b... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. IBA from PAINT node PTN001153077 (beta-catenin/Armadillo family); human CTNNB1 among the sources reflects its own experimental support, as expected. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. UniProtKB:Q8SPJ1 SOURCE STALE OR MISSING Resolved to Q8SPJ1; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 15 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-980526-362 SUPPORTS TRANSFER Resolved to F1QGH7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00006943 SUPPORTS TRANSFER Resolved to Q10953; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-991207-22 SUPPORTS TRANSFER Resolved to Q9PVF7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:A0A1D5NYE8 SOURCE STALE OR MISSING Resolved to A0A1D5NYE8; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 16 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:96650 SOURCE STALE OR MISSING Resolved to Q02257; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. UniProtKB:B6V8E6 SUPPORTS TRANSFER Resolved to B6V8E6; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00000238 SUPPORTS TRANSFER Resolved to Q18825; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. RGD:70487 SUPPORTS TRANSFER Resolved to Q9WU82; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SOURCE STALE OR MISSING Resolved to P18824; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:11793365 Expression of frizzled-related protein and Wnt-signalling mo... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:12138115 Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:12937339 WNT7a induces E-cadherin in lung cancer cells. | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:12970740 Beta-catenin inhibits cell growth of a malignant mesotheliom... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:18787224 Constitutive activation of the Wnt canonical pathway in mant... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:19095296 SFRP1 and SFRP2 suppress the transformation and invasion abi... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:19591802 Parkin protects dopaminergic neurons from excessive Wnt/beta... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:22294297 Non-junctional human desmoglein 3 acts as an upstream regula... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:22467863 Radixin regulates cell migration and cell-cell adhesion thro... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:29739711 SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Sign... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:29910125 DSG2 Is a Functional Cell Surface Marker for Identification ... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:7806582 E-cadherin and APC compete for the interaction with beta-cat... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IDA PMID:9707618 A novel frizzled gene identified in human esophageal carcino... | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: cytoplasm: supported at the stated source and biological scope. Reason: The cytoplasmic pool of beta-catenin is captured by the destruction complex in the absence of Wnt; correct location. The current donor audit recovers Q02248: 16 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244585, 417244675, 417244676, 417244677 and further distinct loci/contexts; references PMID:30659184, PMID:11731231, PMID:11731265. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin |
| GO:0005813 centrosome | IDA PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome sepa... | KEEP AS NON CORE | Summary: centrosome: retain the positive contextual association or function. Reason: Multiple direct localization assays establish a centrosomal pool in the original study, retained outside the primary junctional/transcriptional core. Supporting Evidence: PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome separation |
| GO:0005813 centrosome | IDA PMID:20300119 Conductin/axin2 and Wnt signalling regulates centrosome cohe... | KEEP AS NON CORE | Summary: centrosome: retain the positive contextual association or function. Reason: Original centrosomal phospho-beta-catenin imaging supports this contextual location; the paper was recovered beyond the incomplete local cache. Supporting Evidence: PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome separation |
| GO:0005813 centrosome | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: centrosome: retain the positive contextual association or function. Reason: Literal mouse donor centrosome IDA and human experimental localization agree. Retain the original aggregate electronic source identifiers. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244692; references PMID:20300119. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome separation |
| GO:0005829 cytosol | IDA PMID:10980594 Secreted Frizzled-related proteins inhibit motility and prom... | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: Free beta-catenin and the destruction complex are cytosolic; correct location. Supporting Evidence: |
| GO:0005829 cytosol | IDA PMID:19187541 Issues associated with assessing nuclear localization of N-t... | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The original antibody-specificity study distinguishes a cross-reacting nuclear 8E7 antigen from genuine beta-catenin using deficient cells and additional antibodies. Its controlled HEK293T lithium response and SW480 E-cadherin-reexpression experiments retain positive nuclear/cytosolic redistribution and Wnt-context evidence. Accept the biological assertion without treating every 8E7-stained nucleus as beta-catenin or treating the entire study as a negative localization result. Supporting Evidence: |
| GO:0005829 cytosol | IDA PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: Free beta-catenin and the destruction complex are cytosolic; correct location. Supporting Evidence: |
| GO:0005829 cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: Free beta-catenin and the destruction complex are cytosolic; correct location. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244696, 417244697, 417244698, 417244699; references PMID:12055200, PMID:15673614, PMID:20371816. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195275 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195275, Phosphorylation of APC component of the destruction complex, contains the P35222 entity through input, output, catalystActivity membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195280 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195280, Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195283 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195283, Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, contains the P35222 entity through input, output, catalystActivity membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195287 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195287, Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, contains the P35222 entity through input, output, catalystActivity membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195300 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195300, Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, contains the P35222 entity through input, output, catalystActivity membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195304 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195304, Association of beta-catenin with the destruction complex, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195318 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-195318, Phosphorylation of beta-catenin at Ser45 by CK1 alpha, contains the P35222 entity through input, output, catalystActivity membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-201669 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-201669, Beta-catenin translocates to the nucleus, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-201685 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-201685, Beta-catenin is released from the destruction complex, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-202969 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-202969, Caspase mediated cleavage of beta-catenin, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130279 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-2130279, Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130282 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-2130282, Degradation of ubiquitinated beta catenin by the proteasome, contains the P35222 entity through input membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130286 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-2130286, Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1), contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3134901 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-3134901, LRR FLII-interacting protein 1 associates with beta-catenin, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3134904 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-3134904, Phosphorylation of beta-catenin at Ser552, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3134914 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-3134914, Beta-catenin migrates to the nucleus, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-375140 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-375140, CDO binds promyogenic cadherins, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3769392 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-3769392, YWHAZ and XPO1 mediate the nuclear export of beta-catenin, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-448958 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-448958, Nuclear translocation of p38 MAPK, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5339713 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-5339713, Misspliced GSK3beta mutants stabilize beta-catenin levels, contains the P35222 entity through input membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672304 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-5672304, IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8876497 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-8876497, InlA binds CDH1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8876948 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-8876948, SRC phosphorylates InlA-bound CDH1 and CTNNB1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8876993 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-8876993, CBLL1 binds SRC-phosphorylated CDH1 complex, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8877003 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-8877003, CBLL1 ubiqutinates the InlA-bound CDH1 complex, contains the P35222 entity through input, output, catalystActivity membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9762282 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9762282, CTNNB1 dissociates from CDH11 upon ANGPTL4 binding, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9766219 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9766219, MDM2 binds CDH1, contains the P35222 entity through input membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9816273 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9816273, CDH1 translocates from ER to Golgi, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9816275 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9816275, CDH1 is proteolytically cleaved in Golgi, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9816278 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9816278, CDH1 translocates to the plasma membrane, contains the P35222 entity through input, output, regulatedBy membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817325 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9817325, CDH1 associates with CTNND1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9817330 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9817330, CDH1:CTNNB1 complex binds CTNNA1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9933194 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9933194, CTNNB1, JUP bind CDH1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934294 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9934294, CDH1-associated CTNNA1 binds VCL, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934330 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9934330, CDH1:CTNNB1,JUP complex binds to ANK3, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934410 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9934410, CDH1 forms homotypic trans-dimers, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934411 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9934411, CDH1 forms cis-clusters, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934486 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9934486, CDH1-associated CTNNA1 binds F-actin, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9934751 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9934751, CDH1 is phosphorylated on tyrosine residues, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9935209 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9935209, CDH1 binds to PIP5K1C, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9958889 | ACCEPT | Summary: cytosol: supported at the stated source and biological scope. Reason: The curated event R-HSA-9958889, SRC phosphorylates CDH1, contains the P35222 entity through input, output membership paths. This supports the recorded cytosol context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. |
| GO:0005856 cytoskeleton | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: cytoskeleton: retain the positive contextual association or function. Reason: Beta-catenin links cadherins to the actin cytoskeleton through alpha-catenin but is not itself a cytoskeletal protein; kept as non-core. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin is bound to the cytoplasmic tail of cadherins at the plasma membrane. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | IDA PMID:11790773 Protein binding and functional characterization of plakophil... | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin is bound to the cytoplasmic tail of cadherins at the plasma membrane. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | IDA PMID:12138115 Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -... | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin is bound to the cytoplasmic tail of cadherins at the plasma membrane. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | IDA PMID:12970740 Beta-catenin inhibits cell growth of a malignant mesotheliom... | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin is bound to the cytoplasmic tail of cadherins at the plasma membrane. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin is bound to the cytoplasmic tail of cadherins at the plasma membrane. The current donor audit recovers Q02248: 11 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244705, 417244706, 417244707, 417244708 and further distinct loci/contexts; references PMID:12040017, PMID:16418220, PMID:16740478. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9761421 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: The curated event R-HSA-9761421, CDH11 associates with catenins, contains the P35222 entity through input, output membership paths. This supports the recorded plasma membrane context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9761474 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: The curated event R-HSA-9761474, AMOT-2 binds CDH11, contains the P35222 entity through input, output membership paths. This supports the recorded plasma membrane context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9762246 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: The curated event R-HSA-9762246, ANGPTL4 binds CDH11, contains the P35222 entity through input, output membership paths. This supports the recorded plasma membrane context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9762282 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: The curated event R-HSA-9762282, CTNNB1 dissociates from CDH11 upon ANGPTL4 binding, contains the P35222 entity through input, output membership paths. This supports the recorded plasma membrane context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9921198 | ACCEPT | Summary: plasma membrane: supported at the stated source and biological scope. Reason: The curated event R-HSA-9921198, NS1 binds MMP9 and CTNNB1, contains the P35222 entity through input, output membership paths. This supports the recorded plasma membrane context together with the established beta-catenin compartment biology. A nested complex or modified substrate does not acquire the eventโs catalytic activity; the cellular location is not a claim that beta-catenin performs every reaction in this event. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005911 cell-cell junction | IDA PMID:19151727 Regulation of cardiovascular development and integrity by th... | ACCEPT | Summary: cell-cell junction: supported at the stated source and biological scope. Reason: Beta-catenin is a core component of cadherin-based cell-cell junctions. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005911 cell-cell junction | IDA PMID:19996314 Cell-cell contact formation governs Ca2+ signaling by TRPC4 ... | ACCEPT | Summary: cell-cell junction: supported at the stated source and biological scope. Reason: The original HMEC-1 experiments recover TRPC4 with beta-catenin and show contact-dependent junctional targeting. In HEK293 reconstitution, beta-catenin expression promotes TRPC4-dependent calcium entry in contact-forming cells but retains channel intracellularly in isolated cells. Preserve this conditional association/targeting role. Mouse TRPC4 constructs, human cell hosts and the authorsโ unresolved possibility of additional bridging scaffolds are distinct; the assays do not establish a purified binary interaction. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005911 cell-cell junction | IEA GO_REF:0000107 | ACCEPT | Summary: cell-cell junction: supported at the stated source and biological scope. Reason: Beta-catenin is a core component of cadherin-based cell-cell junctions. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 8 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244724, 417244725, 417244726, 417244728 and further distinct loci/contexts; references PMID:12181493, PMID:14597196, PMID:18816447. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0005912 adherens junction | IBA GO_REF:0000033 | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. IBA from PAINT node PTN001153077 (beta-catenin/Armadillo family); human CTNNB1 among the sources reflects its own experimental support, as expected. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. MGI:MGI:96650 SUPPORTS TRANSFER Resolved to Q02257; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00000238 SUPPORTS TRANSFER Resolved to Q18825; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. RGD:70487 SUPPORTS TRANSFER Resolved to Q9WU82; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 7 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-980526-362 SUPPORTS TRANSFER Resolved to F1QGH7; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:Q8SPJ1 SOURCE STALE OR MISSING Resolved to Q8SPJ1; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. RGD:620412 SUPPORTS TRANSFER Resolved to Q6P0K8; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 20 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-991207-22 SUPPORTS TRANSFER Resolved to Q9PVF7; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IDA PMID:10403777 Regulation of endothelial cell adherens junctions by a Ras-d... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IDA PMID:10725230 ARVCF localizes to the nucleus and adherens junction and is ... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IDA PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome sepa... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: The original localization study also detects beta-catenin at cell-cell adhesion sites, consistent with its established adherens-junction role. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IDA PMID:19101069 beta-catenin is involved in N-cadherin-dependent adhesion, b... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IDA PMID:20086044 Vinculin regulates cell-surface E-cadherin expression by bin... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: The source compares beta-catenin M8P with wild type in vinculin binding and rescue of surface E-cadherin/junctional organization. M8P preserves cadherin and alpha-catenin binding but fails the vinculin-associated surface-stabilization rescue. This supports a structural contribution to cadherin localization/assembly rather than a knockout-only inference. The reported mouse beta-catenin and chick vinculin constructs are distinguished from human MCF10a/Caco2 cell contexts and canine MDCK lysate. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IDA PMID:22855531 Nonredundant roles of cytoplasmic ฮฒ- and ฮณ-actin isoforms in... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IEA GO_REF:0000120 | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. The current donor audit recovers Q02248: 20 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. The current rule genuinely matches ARBA00028426 branch(es) 0,1. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: NO FAILURE CORE Sources checked: ARBA:ARBA00028426 SUPPORTS TRANSFER Actual current matching condition branches 0, 1; all predicates evaluated, with no unknown condition treated as true. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005912 adherens junction | IMP PMID:22294297 Non-junctional human desmoglein 3 acts as an upstream regula... | ACCEPT | Summary: adherens junction: supported at the stated source and biological scope. Reason: Beta-catenin is a defining component of the adherens junction cadherin-catenin complex. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0005916 fascia adherens | IEA GO_REF:0000107 | ACCEPT | Summary: fascia adherens: supported at the stated source and biological scope. Reason: Fascia adherens is the adherens-type junction of the cardiac intercalated disc, where N-cadherin-catenin complexes reside. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244756; references PMID:16481394. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0005923 bicellular tight junction | IEA GO_REF:0000107 | UNDECIDED | Summary: bicellular tight junction: the specific source or functional scope remains unresolved. Reason: The exact mouse donor is Q02248 IDA record 417244757, PMID:17130295, with an embryonic anatomical extension. Its tight-junction localization assay was not independently recovered. Beta-cateninโs established adherens-junction role is not evidence excluding an adjacent or conditional tight-junction pool. Preserve the transfer as unresolved rather than rejecting it by canonical-location preference. Propagation Review Root cause: UNRESOLVED Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244757; references PMID:17130295. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | UNDECIDED | Summary: focal adhesion: the specific source or functional scope remains unresolved. Reason: The source reports a genuine isolated focal-adhesion proteomic survey, but its exact beta-catenin table entry and assay-specific localization were not recovered. A primary adherens-junction role does not exclude detection in that preparation. Preserve the HDA assertion as unresolved; do not infer either a functional focal-adhesion role or contamination from the abstract alone. Supporting Evidence: |
| GO:0005938 cell cortex | IDA PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone... | KEEP AS NON CORE | Summary: cell cortex: retain the positive contextual association or function. Reason: Consistent with cortical/membrane localization at junctions; non-core. Supporting Evidence: |
| GO:0007155 cell adhesion | IEA GO_REF:0000002 | ACCEPT | Summary: cell adhesion: supported at the stated source and biological scope. Reason: Beta-catenin is required for cadherin-mediated cell adhesion; correct though general. Supporting Evidence: PMID:19101069 beta-catenin was located in the cell membrane along with N-cadherin |
| GO:0007155 cell adhesion | IMP PMID:19101069 beta-catenin is involved in N-cadherin-dependent adhesion, b... | ACCEPT | Summary: cell adhesion: supported at the stated source and biological scope. Reason: Beta-catenin is required for cadherin-mediated cell adhesion; correct though general. Supporting Evidence: PMID:19101069 beta-catenin was located in the cell membrane along with N-cadherin |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:18356165 HDAC6 is required for epidermal growth factor-induced beta-c... | KEEP AS NON CORE | Summary: epidermal growth factor receptor signaling pathway: retain the positive contextual association or function. Reason: Beta-catenin is a downstream effector of EGFR signalling in this context; kept as non-core. Supporting Evidence: |
| GO:0008284 positive regulation of cell population proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of cell population proliferation: retain the positive contextual association or function. Reason: Wnt/beta-catenin target genes (e.g. MYC, CCND1) drive proliferation; an animal-specific downstream output, kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244090, 417244430; references PMID:19690384, PMID:12464179. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0008285 negative regulation of cell population proliferation | IDA PMID:12970740 Beta-catenin inhibits cell growth of a malignant mesotheliom... | KEEP AS NON CORE | Summary: negative regulation of cell population proliferation: retain the positive contextual association or function. Reason: Context-specific growth inhibition by overexpressed beta-catenin; kept as non-core. Supporting Evidence: |
| GO:0009410 response to xenobiotic stimulus | IEP PMID:18291362 Sulindac suppresses beta-catenin expression in human cancer ... | UNDECIDED | Summary: response to xenobiotic stimulus: the specific source or functional scope remains unresolved. Reason: The complete abstract and accessible Discussion report reduced beta-catenin abundance, TCF transcriptional activity and target-gene expression after sulindac treatment in human MCF-7, A549 and SW620 cells. The cacheโs full-text flag does not reflect complete access: experimental Methods/Results are absent. The response definition allows expression/activity changes, but these accessible observations do not settle beta-cateninโs performed contribution to the drug response. Preserve the IEP assertion as unresolved without a direct-sensor requirement or a categorical rejection of expression evidence. Supporting Evidence: PMID:18291362 the suppression of beta-catenin, a key mediator of Wnt signaling pathway, was seen in all three cell lines with sulindac administration |
| GO:0010629 negative regulation of gene expression | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of gene expression: retain the positive contextual association or function. Reason: Beta-catenin can repress some genes in specific contexts; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244436; references PMID:19122665. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0010717 regulation of epithelial to mesenchymal transition | IMP PMID:29910125 DSG2 Is a Functional Cell Surface Marker for Identification ... | KEEP AS NON CORE | Summary: regulation of epithelial to mesenchymal transition: retain the positive contextual association or function. Reason: Downstream output of beta-catenin/TCF transcription; kept as non-core. Supporting Evidence: |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | IGI PMID:23983127 Succinate dehydrogenase 5 (SDH5) regulates glycogen synthase... | KEEP AS NON CORE | Summary: positive regulation of epithelial to mesenchymal transition: retain the positive contextual association or function. Reason: Beta-catenin/TCF targets (e.g. via Snail1 stabilization) promote EMT; downstream context, kept as non-core. Supporting Evidence: |
| GO:0010718 positive regulation of epithelial to mesenchymal transition | IMP PMID:17072303 A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in br... | KEEP AS NON CORE | Summary: positive regulation of epithelial to mesenchymal transition: retain the positive contextual association or function. Reason: Beta-catenin/TCF targets (e.g. via Snail1 stabilization) promote EMT; downstream context, kept as non-core. Supporting Evidence: |
| GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process | IMP PMID:15853773 The human D-glucuronyl C5-epimerase gene is transcriptionall... | KEEP AS NON CORE | Summary: positive regulation of heparan sulfate proteoglycan biosynthetic process: retain the positive contextual association or function. Reason: Transcriptional control of a target gene; correct but peripheral. Supporting Evidence: |
| GO:0014704 intercalated disc | IEA GO_REF:0000107 | ACCEPT | Summary: intercalated disc: supported at the stated source and biological scope. Reason: N-cadherin-catenin complexes are core components of the cardiac intercalated disc. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244763; references PMID:17535849. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016020 membrane | IEA GO_REF:0000120 | ACCEPT | Summary: membrane: supported at the stated source and biological scope. Reason: Beta-catenin is membrane-associated through cadherins; correct though general. The current donor audit recovers Q02248: 11 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. The current rule genuinely matches ARBA00028763 branch(es) 24,171. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: NO FAILURE CORE Sources checked: ARBA:ARBA00028763 SUPPORTS TRANSFER Actual current matching condition branches 24, 171; all predicates evaluated, with no unknown condition treated as true. |
| GO:0016020 membrane | ISS GO_REF:0000024 | ACCEPT | Summary: membrane: supported at the stated source and biological scope. Reason: Beta-catenin is membrane-associated through cadherins; correct though general. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q9WU82: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q9WU82 SUPPORTS TRANSFER Resolved accession Q9WU82. Exact records 238477269; references PMID:16815997. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016323 basolateral plasma membrane | IDA PMID:24862762 NHERF1/EBP50 controls morphogenesis of 3D colonic glands by ... | ACCEPT | Summary: basolateral plasma membrane: supported at the stated source and biological scope. Reason: Adherens junctions and lateral cadherin complexes in polarized epithelia. Supporting Evidence: |
| GO:0016323 basolateral plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: basolateral plasma membrane: supported at the stated source and biological scope. Reason: Adherens junctions and lateral cadherin complexes in polarized epithelia. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 8 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244779, 417244780, 417244781, 417244782 and further distinct loci/contexts; references PMID:12885771, PMID:14625387, PMID:15226261. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016327 apicolateral plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: apicolateral plasma membrane: supported at the stated source and biological scope. Reason: Adherens junctions sit at the apicolateral border of epithelial cells. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244788, 417244789; references PMID:29211732. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016328 lateral plasma membrane | IDA PMID:12072559 Subcellular distribution of Wnt pathway proteins in normal a... | ACCEPT | Summary: lateral plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin decorates lateral membranes with E-cadherin in epithelia. Supporting Evidence: |
| GO:0016328 lateral plasma membrane | IDA PMID:22855531 Nonredundant roles of cytoplasmic ฮฒ- and ฮณ-actin isoforms in... | ACCEPT | Summary: lateral plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin decorates lateral membranes with E-cadherin in epithelia. Supporting Evidence: |
| GO:0016328 lateral plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: lateral plasma membrane: supported at the stated source and biological scope. Reason: Beta-catenin decorates lateral membranes with E-cadherin in epithelia. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244794; references PMID:15645444. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016342 catenin complex | IBA GO_REF:0000033 | ACCEPT | Summary: catenin complex: supported at the stated source and biological scope. Reason: Beta-catenin is a core subunit of the cadherin-catenin complex (cadherin, beta-catenin, alpha-catenin, p120). IBA from PAINT node PTN001153077 (beta-catenin/Armadillo family); human CTNNB1 among the sources reflects its own experimental support, as expected. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-991207-22 SUPPORTS TRANSFER Resolved to Q9PVF7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:96650 SUPPORTS TRANSFER Resolved to Q02257; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-980526-362 SUPPORTS TRANSFER Resolved to F1QGH7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0016342 catenin complex | IDA PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | ACCEPT | Summary: catenin complex: supported at the stated source and biological scope. Reason: Beta-catenin is a core subunit of the cadherin-catenin complex (cadherin, beta-catenin, alpha-catenin, p120). Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0016342 catenin complex | IDA PMID:20302655 Epidermal growth factor receptor regulates beta-catenin loca... | ACCEPT | Summary: catenin complex: supported at the stated source and biological scope. Reason: Beta-catenin is a core subunit of the cadherin-catenin complex (cadherin, beta-catenin, alpha-catenin, p120). Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0016342 catenin complex | IDA PMID:28051089 Cadherin 26 is an alpha integrin-binding epithelial receptor... | ACCEPT | Summary: catenin complex: supported at the stated source and biological scope. Reason: Beta-catenin is a core subunit of the cadherin-catenin complex (cadherin, beta-catenin, alpha-catenin, p120). Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0016342 catenin complex | IDA PMID:7650039 Identification of plakoglobin domains required for associati... | ACCEPT | Summary: catenin complex: supported at the stated source and biological scope. Reason: Beta-catenin is a core subunit of the cadherin-catenin complex. The cached abstract focuses on plakoglobin, but the curator read the full text and the location is clearly correct. Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0016342 catenin complex | IEA GO_REF:0000107 | ACCEPT | Summary: catenin complex: supported at the stated source and biological scope. Reason: Beta-catenin is a core subunit of the cadherin-catenin complex (cadherin, beta-catenin, alpha-catenin, p120). Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 3 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244837, 417244838, 417244839; references PMID:11121423, PMID:8853988. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0016525 negative regulation of angiogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of angiogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244447; references PMID:25961718. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016525 negative regulation of angiogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of angiogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244447; references PMID:25961718. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016600 flotillin complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: flotillin complex: retain the positive contextual association or function. Reason: Flotillins associate with cadherin complexes; peripheral location, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244840; references PMID:24046456. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0016922 nuclear receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: nuclear receptor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds and coactivates nuclear receptors (AR, LRH-1/NR5A2, VDR) through its armadillo repeats; structurally defined for LRH-1. IBA from PAINT node PTN001153077 (beta-catenin/Armadillo family); human CTNNB1 among the sources reflects its own experimental support, as expected. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. WB:WBGene00006943 SUPPORTS TRANSFER Resolved to Q10953; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor PMID:22187462 as the first structure of ฮฒ-catenin in complex with any nuclear receptor |
| GO:0016922 nuclear receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: nuclear receptor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds and coactivates nuclear receptors (AR, LRH-1/NR5A2, VDR) through its armadillo repeats; structurally defined for LRH-1. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244365; references PMID:14687547. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor PMID:22187462 as the first structure of ฮฒ-catenin in complex with any nuclear receptor |
| GO:0016922 nuclear receptor binding | IPI PMID:12799378 A direct beta-catenin-independent interaction between androg... | ACCEPT | Summary: nuclear receptor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds and coactivates nuclear receptors (AR, LRH-1/NR5A2, VDR) through its armadillo repeats; structurally defined for LRH-1. Supporting Evidence: PMID:12799378 A recently demonstrated interaction between beta-catenin and the androgen receptor (AR) ligand binding domain |
| GO:0016922 nuclear receptor binding | TAS PMID:16344550 Differential use of functional domains by coiled-coil coacti... | ACCEPT | Summary: nuclear receptor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds and coactivates nuclear receptors (AR, LRH-1/NR5A2, VDR) through its armadillo repeats; structurally defined for LRH-1. Supporting Evidence: PMID:22187462 The LRH-1 binding site in ฮฒ-catenin is also required for association with androgen receptor PMID:22187462 as the first structure of ฮฒ-catenin in complex with any nuclear receptor |
| GO:0019827 stem cell population maintenance | TAS PMID:22723415 Wnt/ฮฒ-catenin signaling regulates telomerase in stem cells a... | KEEP AS NON CORE | Summary: stem cell population maintenance: retain the positive contextual association or function. Reason: Wnt/beta-catenin signalling maintains stem cell populations in many animal tissues; downstream context, kept as non-core. Supporting Evidence: |
| GO:0019899 enzyme binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: enzyme binding: retain the positive contextual association or function. Reason: Beta-catenin binds many enzymes (kinases, E3 ligases, acetyltransferases, Pin1); correct but uninformative, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244368; references PMID:22645310. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0019899 enzyme binding | IPI PMID:11533658 Pin1 regulates turnover and subcellular localization of beta... | KEEP AS NON CORE | Summary: enzyme binding: retain the positive contextual association or function. Reason: Beta-catenin binds many enzymes (kinases, E3 ligases, acetyltransferases, Pin1); correct but uninformative, kept as non-core. Supporting Evidence: |
| GO:0019899 enzyme binding | IPI PMID:18356165 HDAC6 is required for epidermal growth factor-induced beta-c... | KEEP AS NON CORE | Summary: enzyme binding: retain the positive contextual association or function. Reason: The source supports association with HDAC6 in the EGFR/beta-catenin context. Its current official record emphasizes nonhistone deacetylation and cautions about the historical histone-deacetylase designation. Enzyme binding is defensible, but a histone-specific partner refinement is not required by the demonstrated interaction. Supporting Evidence: PMID:23084749 CD133, HDAC6, and the central molecule of the canonical Wnt signaling pathway, ฮฒ-catenin, can physically associate as a ternary complex |
| GO:0019900 kinase binding | IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | MODIFY | Summary: kinase binding: refine the term at the demonstrated source scope. Reason: GSK3B is a protein kinase that phosphorylates beta-catenin in the destruction complex; protein kinase binding is the more specific parent-appropriate term. Proposed replacements: protein kinase binding Supporting Evidence: PMID:17318191 Axin/GSK3beta binding to beta-catenin and its subsequent S/T phosphorylation |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | ACCEPT | Summary: protein kinase binding: supported at the stated source and biological scope. Reason: Beta-catenin binds GSK3B, CK1, NEK2 and tyrosine kinases that phosphorylate it. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244371; references PMID:22899650. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:18086858 We show that beta-catenin binds to and is phosphorylated by Nek2 |
| GO:0019902 phosphatase binding | IPI PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | KEEP AS NON CORE | Summary: phosphatase binding: retain the positive contextual association or function. Reason: The indexed original Results report beta-catenin co-immunoprecipitation with the PTEN C124S substrate-trapping mutant, whereas wild-type PTEN did not co-immunoprecipitate in that comparison. Preserve the positive phosphatase-binding assertion at this mutant/endothelial assay scope; it does not establish a stable wild-type complex or identical behavior of all PTEN constructs. Supporting Evidence: |
| GO:0019903 protein phosphatase binding | IBA GO_REF:0000033 | ACCEPT | Summary: protein phosphatase binding: supported at the stated source and biological scope. Reason: Protein-phosphatase binding is supported by human beta-catenin association with PTPRJ/DEP1 in the original substrate-trapping experiments and with active PTPRZ1 in the separately inspected source. These positive interactions support the class without requiring PTPRU to be catalytic. PTPRU association remains positive, but later biochemical/structural evidence establishes its pseudophosphatase status and disputes the old dephosphorylation interpretation. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching protein-phosphatase-binding IBD at PTN001153077. The literal source list contains mouse and bovine descendant evidence plus the ancestral node; it does not list human CTNNB1 as a donor for this row. This valid node placement is distinct from historical catalytic claims about any one partner. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. |
| GO:0019903 protein phosphatase binding | IEA GO_REF:0000107 | ACCEPT | Summary: protein phosphatase binding: supported at the stated source and biological scope. Reason: Protein-phosphatase binding is supported by human beta-catenin association with PTPRJ/DEP1 in the original substrate-trapping experiments and with active PTPRZ1 in the separately inspected source. These positive interactions support the class without requiring PTPRU to be catalytic. PTPRU association remains positive, but later biochemical/structural evidence establishes its pseudophosphatase status and disputes the old dephosphorylation interpretation. The mouse Q02248 donor has exact IPI source record 417244375, with partner O14522; its original experiment was not independently reread. The literal orthology source and assay context are retained separately from the independent human binding evidence. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244375; references PMID:16973135. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0021854 hypothalamus development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: hypothalamus development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244448; references PMID:32868762. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0030018 Z disc | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Z disc: retain the positive contextual association or function. Reason: Cardiomyocyte localization near the costamere/Z-disc region; peripheral, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244795, 417244796; references PMID:8821035. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0030027 lamellipodium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: lamellipodium: retain the positive contextual association or function. Reason: Peripheral location in migrating cells; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244797; references PMID:14657280. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0030054 cell junction | IDA PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone... | ACCEPT | Summary: cell junction: supported at the stated source and biological scope. Reason: Beta-catenin is a core junctional protein. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0030054 cell junction | IDA PMID:20412773 The Hippo pathway regulates Wnt/beta-catenin signaling. | ACCEPT | Summary: cell junction: supported at the stated source and biological scope. Reason: Beta-catenin is a core junctional protein. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0030054 cell junction | TAS PMID:17047063 E-cadherin regulates human Nanos1, which interacts with p120... | ACCEPT | Summary: cell junction: supported at the stated source and biological scope. Reason: Beta-catenin is a core junctional protein. Supporting Evidence: PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0030182 neuron differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: neuron differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244449; references PMID:25009587. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0030331 obsolete nuclear estrogen receptor binding | IPI PMID:15304487 Wnt/beta-catenin and estrogen signaling converge in vivo. | MODIFY | Summary: obsolete nuclear estrogen receptor binding: refine the term at the demonstrated source scope. Reason: GO:0030331 is obsolete; GO recommends GO:0016922 nuclear receptor binding, with the estrogen receptor as has_input. Proposed replacements: nuclear receptor binding Supporting Evidence: PMID:15304487 estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes |
| GO:0030877 beta-catenin destruction complex | IDA PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d... | ACCEPT | Summary: beta-catenin destruction complex: supported at the stated source and biological scope. Reason: In the absence of Wnt, cytoplasmic beta-catenin is bound by APC/Axin and phosphorylated by CK1 and GSK3B within this complex before beta-TrCP-mediated degradation. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin PMID:17318191 Axin/GSK3beta binding to beta-catenin and its subsequent S/T phosphorylation |
| GO:0030877 beta-catenin destruction complex | IDA PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | ACCEPT | Summary: beta-catenin destruction complex: supported at the stated source and biological scope. Reason: In the absence of Wnt, cytoplasmic beta-catenin is bound by APC/Axin and phosphorylated by CK1 and GSK3B within this complex before beta-TrCP-mediated degradation. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin PMID:17318191 Axin/GSK3beta binding to beta-catenin and its subsequent S/T phosphorylation |
| GO:0030877 beta-catenin destruction complex | IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | ACCEPT | Summary: beta-catenin destruction complex: supported at the stated source and biological scope. Reason: In the absence of Wnt, cytoplasmic beta-catenin is bound by APC/Axin and phosphorylated by CK1 and GSK3B within this complex before beta-TrCP-mediated degradation. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin PMID:17318191 Axin/GSK3beta binding to beta-catenin and its subsequent S/T phosphorylation |
| GO:0030877 beta-catenin destruction complex | IEA GO_REF:0000107 | ACCEPT | Summary: beta-catenin destruction complex: supported at the stated source and biological scope. Reason: In the absence of Wnt, cytoplasmic beta-catenin is bound by APC/Axin and phosphorylated by CK1 and GSK3B within this complex before beta-TrCP-mediated degradation. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244844; references PMID:10318824. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:8638126 The APC protein binds to the cellular adhesion molecule beta-catenin PMID:17318191 Axin/GSK3beta binding to beta-catenin and its subsequent S/T phosphorylation |
| GO:0030901 midbrain development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: midbrain development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244450; references PMID:11262227. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0030902 hindbrain development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: hindbrain development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244451; references PMID:11262227. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0030997 regulation of centriole-centriole cohesion | IDA PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome sepa... | KEEP AS NON CORE | Summary: regulation of centriole-centriole cohesion: retain the positive contextual association or function. Reason: Original perturbation, local association and separation experiments support contextual regulation of the centriolar linker; the detailed scaffolding mechanism remains proposed. Supporting Evidence: PMID:18086858 beta-Catenin is a Nek2 substrate involved in centrosome separation |
| GO:0031253 cell projection membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cell projection membrane: retain the positive contextual association or function. Reason: Peripheral location; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244801; references PMID:16621792. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0031396 regulation of protein ubiquitination | IMP PMID:15829978 Functional correlates of mutation of the Asp32 and Gly34 res... | KEEP AS NON CORE | Summary: regulation of protein ubiquitination: retain the positive contextual association or function. Reason: PMID:15829978 tests ubiquitination of beta-catenin itself after destruction-motif mutation; that substrate assay does not establish a regulatory function. Independent PMID:23245942 explicitly reports phosphorylated beta-catenin bridging TAZ to beta-TrCP, providing a mechanistic contribution to another proteinโs ubiquitin-dependent turnover. Retain the general process as a contextual role on that independent evidence, without assigning ubiquitin-ligase catalysis or reinterpreting the original mutant assay. The latter paperโs abstract was accessible; its detailed constructs and assays were not independently inspected. Supporting Evidence: PMID:23245942 TAZ degradation depends on phosphorylated ฮฒ-catenin that bridges TAZ to its ubiquitin ligase ฮฒ-TrCP. PMID:15829978 Since D32 and G34 are part of the ubiquitination destruction motif |
| GO:0031528 microvillus membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: microvillus membrane: retain the positive contextual association or function. Reason: Peripheral location; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244802; references PMID:16439479. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0031625 ubiquitin protein ligase binding | EXP PMID:12820959 Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruc... | ACCEPT | Summary: ubiquitin protein ligase binding: supported at the stated source and biological scope. Reason: The phosphodegron of beta-catenin is bound by the SCF(beta-TrCP) WD40 domain; structurally defined. Supporting Evidence: PMID:12820959 The F box protein beta-TrCP1 recognizes the doubly phosphorylated DpSGphiXpS destruction motif, present in beta-catenin and IkappaB |
| GO:0032212 positive regulation of telomere maintenance via telomerase | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of telomere maintenance via telomerase: retain the positive contextual association or function. Reason: Downstream target-gene output; kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244047; references PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:22723415 ฮฒ-Catenin binds to the Tert promoter in a mouse intestinal tumor model and in human carcinoma cells |
| GO:0032355 response to estradiol | IDA PMID:15304487 Wnt/beta-catenin and estrogen signaling converge in vivo. | KEEP AS NON CORE | Summary: response to estradiol: retain the positive contextual association or function. Reason: Crosstalk with estrogen signalling; non-core. Supporting Evidence: PMID:15304487 estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes |
| GO:0032968 positive regulation of transcription elongation by RNA polymerase II | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of transcription elongation by RNA polymerase II: retain the positive contextual association or function. Reason: Consistent with beta-catenin recruiting the PAF1 complex via parafibromin; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244460; references PMID:30478225. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0032991 protein-containing complex | IDA PMID:22083958 Histone H1 recruitment by CHD8 is essential for suppression ... | KEEP AS NON CORE | Summary: protein-containing complex: retain the positive contextual association or function. Reason: Correct but uninformative CC; kept as non-core. Supporting Evidence: PMID:22083958 CHD8 promotes the association of ฮฒ-catenin and histone H1, with formation of the trimeric complex on chromatin |
| GO:0032993 protein-DNA complex | IDA PMID:10825188 Differential mechanisms of LEF/TCF family-dependent transcri... | KEEP AS NON CORE | Summary: protein-DNA complex: retain the positive contextual association or function. Reason: Beta-catenin enters protein-DNA complexes through LEF/TCF; non-core location term. Supporting Evidence: PMID:10825188 formed a beta-catenin-LEF-DNA complex |
| GO:0033234 negative regulation of protein sumoylation | IDA PMID:22155184 ฮฒ-catenin inhibits promyelocytic leukemia protein tumor supp... | KEEP AS NON CORE | Summary: negative regulation of protein sumoylation: retain the positive contextual association or function. Reason: The complete source abstract explicitly reports beta-catenin interaction with PML-IV and inhibition of RANBP2-mediated PML-IV SUMOylation, accompanied by altered PML nuclear-body organization in colorectal cancer cells. This is a regulatory contribution to another proteinโs modification, not beta-catenin merely serving as the modified substrate. Retain the contextual process; the detailed full original was not recovered. Supporting Evidence: PMID:22155184 ฮฒ-catenin inhibited Ran-binding protein 2-mediated SUMOylation of PML-IV |
| GO:0034112 positive regulation of homotypic cell-cell adhesion | IGI PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | KEEP AS NON CORE | Summary: positive regulation of homotypic cell-cell adhesion: retain the positive contextual association or function. Reason: Consistent with its adherens-junction role; kept as non-core. Supporting Evidence: |
| GO:0034333 adherens junction assembly | IMP PMID:20086044 Vinculin regulates cell-surface E-cadherin expression by bin... | ACCEPT | Summary: adherens junction assembly: supported at the stated source and biological scope. Reason: The source compares beta-catenin M8P with wild type in vinculin binding and rescue of surface E-cadherin/junctional organization. M8P preserves cadherin and alpha-catenin binding but fails the vinculin-associated surface-stabilization rescue. This supports a structural contribution to cadherin localization/assembly rather than a knockout-only inference. The reported mouse beta-catenin and chick vinculin constructs are distinguished from human MCF10a/Caco2 cell contexts and canine MDCK lysate. Supporting Evidence: PMID:20086044 an interaction between beta-catenin and vinculin is crucial for stabilizing E-cadherin at the cell surface PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0034333 adherens junction assembly | IMP PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | ACCEPT | Summary: adherens junction assembly: supported at the stated source and biological scope. Reason: Beta-catenin binding to cadherins is required for adherens junction formation and for stabilizing E-cadherin at the cell surface; beta-catenin is a structural participant. Supporting Evidence: PMID:20086044 an interaction between beta-catenin and vinculin is crucial for stabilizing E-cadherin at the cell surface PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0034394 protein localization to cell surface | IMP PMID:20086044 Vinculin regulates cell-surface E-cadherin expression by bin... | KEEP AS NON CORE | Summary: protein localization to cell surface: retain the positive contextual association or function. Reason: The source compares beta-catenin M8P with wild type in vinculin binding and rescue of surface E-cadherin/junctional organization. M8P preserves cadherin and alpha-catenin binding but fails the vinculin-associated surface-stabilization rescue. This supports a structural contribution to cadherin localization/assembly rather than a knockout-only inference. The reported mouse beta-catenin and chick vinculin constructs are distinguished from human MCF10a/Caco2 cell contexts and canine MDCK lysate. Supporting Evidence: PMID:20086044 an interaction between beta-catenin and vinculin is crucial for stabilizing E-cadherin at the cell surface |
| GO:0034750 Scrib-APC-beta-catenin complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Scrib-APC-beta-catenin complex: retain the positive contextual association or function. Reason: A peripheral junction-associated complex; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244852; references PMID:16611247. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0035315 hair cell differentiation | TAS PMID:19251162 Pitx2, a beta-catenin-regulated transcription factor, regula... | UNDECIDED | Summary: hair cell differentiation: the specific source or functional scope remains unresolved. Reason: The accessible original abstract concerns PITX2, LEF1/beta-catenin and keratin expression in human hair-follicle cells, not a mouse transfer or an inner-ear experiment. The current hair-cell-differentiation definition is broad, but the relevant full assay establishing the specific differentiation endpoint was not recovered. Preserve this TAS assertion as unresolved without an anatomy-based rejection. Supporting Evidence: |
| GO:0035995 detection of muscle stretch | TAS PMID:30568254 PI3Kฮฑ-regulated gelsolin activity is a critical determinant ... | UNDECIDED | Summary: detection of muscle stretch: the specific source or functional scope remains unresolved. Reason: The TAS source explicitly attributes sensing to the N-cadherin/beta-catenin complex and reports target responses in mouse hearts. Its traced operative primary experiments could not be fully assessed here. The specific muscle-stretch detection assertion therefore remains unresolved; neither background mention nor lack of autonomous sensing establishes over-annotation. Supporting Evidence: PMID:30568254 The intercellular N-cadherin/ฮฒ-catenin complex9,23,24 and the integrin-based/focal adhesion kinase (FAK) complex are important mechanosensors |
| GO:0036023 embryonic skeletal limb joint morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: embryonic skeletal limb joint morphogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244473; references PMID:21262216. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0036023 embryonic skeletal limb joint morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: embryonic skeletal limb joint morphogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244473; references PMID:21262216. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0036520 astrocyte-dopaminergic neuron signaling | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: astrocyte-dopaminergic neuron signaling: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244474; references PMID:21752258. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0042734 presynaptic membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: presynaptic membrane: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244587, 417244588, 417244589, 417244590; references PMID:8909549. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:12651860 The cohesin SMC3 is a target the for beta-catenin/TCF4 trans... | KEEP AS NON CORE | Summary: positive regulation of apoptotic process: retain the positive contextual association or function. Reason: Context-specific outcome of overexpressed or deregulated beta-catenin in cancer cell lines; kept as non-core. Supporting Evidence: |
| GO:0043065 positive regulation of apoptotic process | IDA PMID:12970740 Beta-catenin inhibits cell growth of a malignant mesotheliom... | KEEP AS NON CORE | Summary: positive regulation of apoptotic process: retain the positive contextual association or function. Reason: Context-specific outcome of overexpressed or deregulated beta-catenin in cancer cell lines; kept as non-core. Supporting Evidence: |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:12154096 Wnt signaling protects 3T3-L1 preadipocytes from apoptosis t... | KEEP AS NON CORE | Summary: negative regulation of apoptotic process: retain the positive contextual association or function. Reason: Wnt/beta-catenin target genes promote survival in several cell types; downstream context, kept as non-core. Supporting Evidence: |
| GO:0043066 negative regulation of apoptotic process | TAS PMID:23164821 Clusterin regulates ฮฒ-amyloid toxicity via Dickkopf-1-driven... | KEEP AS NON CORE | Summary: negative regulation of apoptotic process: retain the positive contextual association or function. Reason: Wnt/beta-catenin target genes promote survival in several cell types; downstream context, kept as non-core. Supporting Evidence: |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | IDA PMID:29374064 Forkhead Box F2 Suppresses Gastric Cancer through a Novel FO... | REMOVE | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process: the specific source assignment is contradicted or assigns the wrong performed role. Reason: The recovered source identifies beta-catenin as the IRF2BPL-modified substrate whose ubiquitination and proteasomal turnover change after FOXF2/IRF2BPL perturbation. It does not show beta-catenin carrying out the proteolytic step. Reject this source-specific catabolic participation assignment while preserving the observed turnover and original experimental tuple; separate regulation of TAZ turnover does not turn beta-catenin into the proteasome. Supporting Evidence: PMID:29374064 IRF2BPL in turn interacted with ฮฒ-catenin, increasing its ubiquitination and degradation |
| GO:0043296 apical junction complex | IEA GO_REF:0000107 | ACCEPT | Summary: apical junction complex: supported at the stated source and biological scope. Reason: Adherens junctions are part of the apical junctional complex of epithelia. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 3 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244806, 417244807, 417244808; references PMID:16249236, PMID:17130295, PMID:17666436. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0043525 positive regulation of neuron apoptotic process | IDA PMID:19591802 Parkin protects dopaminergic neurons from excessive Wnt/beta... | KEEP AS NON CORE | Summary: positive regulation of neuron apoptotic process: retain the positive contextual association or function. Reason: Context-specific; kept as non-core. Supporting Evidence: |
| GO:0044325 transmembrane transporter binding | IPI PMID:19996314 Cell-cell contact formation governs Ca2+ signaling by TRPC4 ... | KEEP AS NON CORE | Summary: transmembrane transporter binding: retain the positive contextual association or function. Reason: The original HMEC-1 experiments recover TRPC4 with beta-catenin and show contact-dependent junctional targeting. In HEK293 reconstitution, beta-catenin expression promotes TRPC4-dependent calcium entry in contact-forming cells but retains channel intracellularly in isolated cells. Preserve this conditional association/targeting role. Mouse TRPC4 constructs, human cell hosts and the authorsโ unresolved possibility of additional bridging scaffolds are distinct; the assays do not establish a purified binary interaction. Supporting Evidence: |
| GO:0044331 cell-cell adhesion mediated by cadherin | IMP PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | ACCEPT | Summary: cell-cell adhesion mediated by cadherin: supported at the stated source and biological scope. Reason: Beta-catenin is a structural participant in cadherin-mediated adhesion: it binds the cadherin tail and stabilizes the complex at the membrane. Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0045177 apical part of cell | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: apical part of cell: retain the positive contextual association or function. Reason: Peripheral location; kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244809, 417244810, 417244811, 417244812; references PMID:14758363, PMID:15037549, PMID:16249236. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0045202 synapse | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: synapse: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244814, 417244815; references PMID:20705246, PMID:25232112. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0045202 synapse | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: synapse: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244814, 417244815; references PMID:20705246, PMID:25232112. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0045211 postsynaptic membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: postsynaptic membrane: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244591, 417244592, 417244593, 417244594; references PMID:8909549. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0045294 alpha-catenin binding | IBA GO_REF:0000033 | ACCEPT | Summary: alpha-catenin binding: supported at the stated source and biological scope. Reason: Specific alpha-catenin binding is supported by the targeted originals at their stated access limits. The actual ancestral-node reconstruction supports the inherited function without asserting universal equivalence of every species or experimental product. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. RGD:70487 SUPPORTS TRANSFER Resolved to Q9WU82; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:96650 SUPPORTS TRANSFER Resolved to Q02257; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin PMID:9264463 Here we have now identified the reciprocal complementary binding site in alpha-catenin which mediates its interaction with beta-catenin and plakoglobin |
| GO:0045294 alpha-catenin binding | IEA GO_REF:0000107 | ACCEPT | Summary: alpha-catenin binding: supported at the stated source and biological scope. Reason: The N-terminal region of beta-catenin binds alpha-catenin, which links the cadherin-catenin complex to actin. Some cited papers emphasize plakoglobin, but alpha-catenin binding by beta-catenin is well established. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244387, 417244388; references PMID:12432063, PMID:21393547. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin PMID:9264463 Here we have now identified the reciprocal complementary binding site in alpha-catenin which mediates its interaction with beta-catenin and plakoglobin |
| GO:0045294 alpha-catenin binding | IPI PMID:23136403 Mutations in the area composita protein ฮฑT-catenin are assoc... | ACCEPT | Summary: alpha-catenin binding: supported at the stated source and biological scope. Reason: The N-terminal region of beta-catenin binds alpha-catenin, which links the cadherin-catenin complex to actin. Some cited papers emphasize plakoglobin, but alpha-catenin binding by beta-catenin is well established. Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin PMID:9264463 Here we have now identified the reciprocal complementary binding site in alpha-catenin which mediates its interaction with beta-catenin and plakoglobin |
| GO:0045294 alpha-catenin binding | IPI PMID:7650039 Identification of plakoglobin domains required for associati... | ACCEPT | Summary: alpha-catenin binding: supported at the stated source and biological scope. Reason: Alpha-catenin binding by beta-catenin is well established. The cached abstract of this paper maps plakoglobin domains, but the curator read the full text; the function is clearly correct for beta-catenin. Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin PMID:9264463 Here we have now identified the reciprocal complementary binding site in alpha-catenin which mediates its interaction with beta-catenin and plakoglobin |
| GO:0045294 alpha-catenin binding | IPI PMID:7890674 The APC protein and E-cadherin form similar but independent ... | ACCEPT | Summary: alpha-catenin binding: supported at the stated source and biological scope. Reason: The source abstract explicitly distinguishes alpha-catenin binding to beta-catenin from absence of direct alpha-cateninโAPC binding, and maps beta-catenin binding activity to its amino-terminal half. Retain this positive specific interaction; the unrecovered full text limits reagent and detailed assay claims, not the clearly reported result. Supporting Evidence: PMID:7890674 although the amino-terminal half independently binds alpha-catenin PMID:9264463 Here we have now identified the reciprocal complementary binding site in alpha-catenin which mediates its interaction with beta-catenin and plakoglobin |
| GO:0045296 cadherin binding | HDA PMID:25468996 E-cadherin interactome complexity and robustness resolved by... | ACCEPT | Summary: cadherin binding: supported at the stated source and biological scope. Reason: Beta-catenin binds the cytoplasmic domain of classical cadherins (E-, N-, VE-cadherin) through its armadillo-repeat groove; this is its core junctional activity. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0045296 cadherin binding | IBA GO_REF:0000033 | ACCEPT | Summary: cadherin binding: supported at the stated source and biological scope. Reason: Beta-catenin binds the cytoplasmic cadherin tail within the junctional assembly, distinct from intrinsic adhesion of an extracellular receptor. GO:0098641 adds an adhesion-process constraint; the broader inherited cadherin-binding function need not be restricted to that single context. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. ZFIN:ZDB-GENE-980526-362 SUPPORTS TRANSFER Resolved to F1QGH7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 5 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. RGD:70487 SUPPORTS TRANSFER Resolved to Q9WU82; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0045296 cadherin binding | IEA GO_REF:0000120 | ACCEPT | Summary: cadherin binding: supported at the stated source and biological scope. Reason: Beta-catenin binds the cytoplasmic domain of classical cadherins (E-, N-, VE-cadherin) through its armadillo-repeat groove; this is its core junctional activity. The current donor audit recovers Q02248: 5 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. The current rule genuinely matches ARBA00092450 branch(es) 3. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: NO FAILURE CORE Sources checked: ARBA:ARBA00092450 SUPPORTS TRANSFER Actual current matching condition branches 3; all predicates evaluated, with no unknown condition treated as true. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0045296 cadherin binding | IPI PMID:18287330 VE-cadherin and beta-catenin binding dynamics during histami... | ACCEPT | Summary: cadherin binding: supported at the stated source and biological scope. Reason: Beta-catenin binds the cytoplasmic domain of classical cadherins (E-, N-, VE-cadherin) through its armadillo-repeat groove; this is its core junctional activity. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0045296 cadherin binding | IPI PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | ACCEPT | Summary: cadherin binding: supported at the stated source and biological scope. Reason: Beta-catenin binds the cytoplasmic domain of classical cadherins (E-, N-, VE-cadherin) through its armadillo-repeat groove; this is its core junctional activity. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins PMID:18287330 linking the VE-cadherin junction complex to the cytoskeleton |
| GO:0045597 positive regulation of cell differentiation | NAS PMID:24847765 From inception to output, Tcf1 and Lef1 safeguard developmen... | KEEP AS NON CORE | Summary: positive regulation of cell differentiation: retain the positive contextual association or function. Reason: Downstream developmental output; kept as non-core. Supporting Evidence: |
| GO:0045765 regulation of angiogenesis | TAS PMID:18756595 Prognostic significance of BMP and activin membrane-bound in... | KEEP AS NON CORE | Summary: regulation of angiogenesis: retain the positive contextual association or function. Reason: Downstream context; kept as non-core. Supporting Evidence: |
| GO:0045766 positive regulation of angiogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: positive regulation of angiogenesis: retain the positive contextual association or function. Reason: Downstream context; kept as non-core. The current rule genuinely matches ARBA00084376 branch(es) 3. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00084376 SUPPORTS TRANSFER Actual current matching condition branches 3; all predicates evaluated, with no unknown condition treated as true. |
| GO:0045892 negative regulation of DNA-templated transcription | IMP PMID:19653274 Lef-1 isoforms regulate different target genes and reduce ce... | UNDECIDED | Summary: negative regulation of DNA-templated transcription: the specific source or functional scope remains unresolved. Reason: The accessible abstract reports beta-catenin-independent E-cadherin repression by a LEF1 exon-VI-deleted product, but the full original could not be recovered. That negative clause does not establish that the curatorโs entire beta-catenin assay is wrong. Preserve the original IMP assertion as unresolved pending the exact construct and repression experiment. Supporting Evidence: PMID:19653274 Forced expression of Lef-1 Deltaexon VI inhibited E-cadherin expression in a beta-catenin-independent way |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:12970740 Beta-catenin inhibits cell growth of a malignant mesotheliom... | ACCEPT | Summary: positive regulation of DNA-templated transcription: supported at the stated source and biological scope. Reason: Beta-catenin activates TCF/LEF target genes as a coactivator. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:18787224 Constitutive activation of the Wnt canonical pathway in mant... | ACCEPT | Summary: positive regulation of DNA-templated transcription: supported at the stated source and biological scope. Reason: Beta-catenin activates TCF/LEF target genes as a coactivator. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000107 | ACCEPT | Summary: positive regulation of DNA-templated transcription: supported at the stated source and biological scope. Reason: Beta-catenin activates TCF/LEF target genes as a coactivator. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 10 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244160, 417244161, 417244162, 417244163 and further distinct loci/contexts; references PMID:10631168, PMID:12551949, PMID:15866163. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:12949260 Wnt4 overexpression disrupts normal testicular vasculature a... | ACCEPT | Summary: positive regulation of DNA-templated transcription: supported at the stated source and biological scope. Reason: Beta-catenin activates TCF/LEF target genes as a coactivator. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Human cell-free transcription directly supports positive RNA polymerase II regulation, and the actual matching ancestral-node placement supports the inherited biological function. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 18 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 8 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00000238 SUPPORTS TRANSFER Resolved to Q18825; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00006943 SUPPORTS TRANSFER Resolved to Q10953; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 6 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:11751639 Chromatin-specific regulation of LEF-1-beta-catenin transcri... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Direct beta-catenin-dependent activation in the chromatin transcription system supports positive regulation of Pol II transcription. LEF1 is the DNA-recognition factor; HeLa nuclear extract supplies transcription machinery. Do not equate this with intrinsic DNA binding or histone-modifying/ATPase catalysis by beta-catenin. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:12651860 The cohesin SMC3 is a target the for beta-catenin/TCF4 trans... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:14660579 Identification of BMP and activin membrane-bound inhibitor (... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:9065402 Activation of beta-catenin-Tcf signaling in colon cancer by ... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:15592430 FGF-20 and DKK1 are transcriptional targets of beta-catenin ... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IMP PMID:19328798 A colorectal cancer expression profile that includes transfo... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 18 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244168, 417244169, 417244170, 417244171 and further distinct loci/contexts; references PMID:15024079, PMID:15729346, PMID:15778706. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | TAS PMID:24115276 The regulation and deregulation of Wnt signaling by PARK gen... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045944 positive regulation of transcription by RNA polymerase II | TAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | ACCEPT | Summary: positive regulation of transcription by RNA polymerase II: supported at the stated source and biological scope. Reason: Beta-catenin coactivates Pol II target genes with TCF/LEF; this is the process its core activity serves. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:11751639 beta-catenin, a dedicated coactivator of LEF/TCF enhancer-binding proteins |
| GO:0045976 negative regulation of mitotic cell cycle, embryonic | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of mitotic cell cycle, embryonic: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244504; references PMID:21325504. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0045976 negative regulation of mitotic cell cycle, embryonic | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of mitotic cell cycle, embryonic: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244504; references PMID:21325504. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0046332 SMAD binding | IPI PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | KEEP AS NON CORE | Summary: SMAD binding: retain the positive contextual association or function. Reason: Smad7 binds and stabilizes beta-catenin at E-cadherin complexes; correct but peripheral. Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0048145 regulation of fibroblast proliferation | TAS PMID:16858403 The inner nuclear membrane protein emerin regulates beta-cat... | KEEP AS NON CORE | Summary: regulation of fibroblast proliferation: retain the positive contextual association or function. Reason: Downstream context; kept as non-core. Supporting Evidence: |
| GO:0048471 perinuclear region of cytoplasm | IDA PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone... | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm: retain the positive contextual association or function. Reason: Peripheral location; kept as non-core. Supporting Evidence: |
| GO:0048568 embryonic organ development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: embryonic organ development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244505; references PMID:30478225. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0048643 positive regulation of skeletal muscle tissue development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of skeletal muscle tissue development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244506; references PMID:23460868. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0048660 regulation of smooth muscle cell proliferation | IMP PMID:17122440 Regulation of smooth muscle cell proliferation by beta-caten... | KEEP AS NON CORE | Summary: regulation of smooth muscle cell proliferation: retain the positive contextual association or function. Reason: Downstream context of beta-catenin/TCF transcription; kept as non-core. Supporting Evidence: |
| GO:0050767 regulation of neurogenesis | NAS PMID:23377854 Physiological role of ฮฒ-catenin/TCF signaling in neurons of ... | KEEP AS NON CORE | Summary: regulation of neurogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process supported at the stated reference and evidence-code scope. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Supporting Evidence: |
| GO:0050767 regulation of neurogenesis | TAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | KEEP AS NON CORE | Summary: regulation of neurogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process supported at the stated reference and evidence-code scope. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Supporting Evidence: |
| GO:0050768 negative regulation of neurogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of neurogenesis: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244511; references PMID:26371318. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0050982 detection of mechanical stimulus | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: detection of mechanical stimulus: retain the positive contextual association or function. Reason: Retain contextual mechanical detection as an explicit inference to conserved human junctional machinery. The matching primate beta-catenin FunFam rule and molecular force-sensitive interface evidence support the broad assertion; the latter is a Drosophila experiment with mouse-structure simulations, not direct human or muscle evidence. Beta-catenin contributes the responsive interface rather than merely being an unrelated downstream substrate. The current rule genuinely matches ARBA00091369 branch(es) 1. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00091369 SUPPORTS TRANSFER Actual current matching condition branches 1; all predicates evaluated, with no unknown condition treated as true. Supporting Evidence: |
| GO:0051884 regulation of timing of anagen | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of timing of anagen: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244512; references PMID:24681597. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0051963 regulation of synapse assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of synapse assembly: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244513, 417244514, 417244515, 417244516; references PMID:28641114. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0060070 canonical Wnt signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: The human product performs transcriptional coactivation downstream in canonical Wnt signaling. This supports the biological scope without assigning kinase or proteolytic activity or inferring a gene-origin date. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 17 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-040426-2575 SUPPORTS TRANSFER Resolved to Q8JID2; 4 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00006943 SUPPORTS TRANSFER Resolved to Q10953; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SUPPORTS TRANSFER Resolved to O44326; 3 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00000238 SUPPORTS TRANSFER Resolved to Q18825; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P26233 SUPPORTS TRANSFER Resolved to P26233; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 23 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. ZFIN:ZDB-GENE-980526-362 SUPPORTS TRANSFER Resolved to F1QGH7; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SUPPORTS TRANSFER Resolved to P35222; 9 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:10644691 Protein phosphatase 2Calpha dephosphorylates axin and activa... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:11751639 Chromatin-specific regulation of LEF-1-beta-catenin transcri... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin performs the nuclear coactivation step of canonical Wnt signaling. This is participation, not merely a pathway substrate or a necessity phenotype. The source reconstructs a downstream LEF1 transcriptional step and tests its inhibitors; it is not a complete ligand-to-receptor signaling reconstitution. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:12937339 WNT7a induces E-cadherin in lung cancer cells. | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:19187541 Issues associated with assessing nuclear localization of N-t... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: The original antibody-specificity study distinguishes a cross-reacting nuclear 8E7 antigen from genuine beta-catenin using deficient cells and additional antibodies. Its controlled HEK293T lithium response and SW480 E-cadherin-reexpression experiments retain positive nuclear/cytosolic redistribution and Wnt-context evidence. Accept the biological assertion without treating every 8E7-stained nucleus as beta-catenin or treating the entire study as a negative localization result. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 23 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244192, 417244193, 417244194, 417244195 and further distinct loci/contexts; references PMID:12235125, PMID:12464179, PMID:12717450. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IGI PMID:27846906 Upregulation of miR-501-5p activates the wnt/ฮฒ-catenin signa... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Shows that miR-501-5p activates Wnt/beta-catenin signalling upstream of beta-catenin; beta-catenin itself is the transducer of the pathway, so the annotation is accepted. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:12154096 Wnt signaling protects 3T3-L1 preadipocytes from apoptosis t... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:17072303 A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in br... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 23 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244192, 417244193, 417244194, 417244195 and further distinct loci/contexts; references PMID:12235125, PMID:12464179, PMID:12717450. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060070 canonical Wnt signaling pathway | TAS PMID:23164821 Clusterin regulates ฮฒ-amyloid toxicity via Dickkopf-1-driven... | ACCEPT | Summary: canonical Wnt signaling pathway: supported at the stated source and biological scope. Reason: Beta-catenin is the central transducer of canonical Wnt signalling: Wnt stabilizes it and it coactivates TCF/LEF target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:9065402 colorectal tumors with intact APC genes were found to contain activating mutations of beta-catenin that altered functionally significant phosphorylation sites |
| GO:0060231 mesenchymal to epithelial transition | IMP PMID:29910125 DSG2 Is a Functional Cell Surface Marker for Identification ... | KEEP AS NON CORE | Summary: mesenchymal to epithelial transition: retain the positive contextual association or function. Reason: Downstream output of beta-catenin/TCF transcription; kept as non-core. Supporting Evidence: |
| GO:0060292 long-term synaptic depression | ISS GO_REF:0000024 | UNDECIDED | Summary: long-term synaptic depression: the specific source or functional scope remains unresolved. Reason: The human GO-CAM activity 62900b6400001715 is a transcription-coactivator node in chromatin, embedded in hippocampal LTD and transferred from rat RGD:70487. The exact rat LTD annotation was not recovered in the current source snapshot. The selected PMID:33428810 mouse PTEN experiments support beta-catenin promoter occupancy and a proposed transcriptional connection, but do not independently resolve a beta-catenin-specific LTD performance assay in the inspected scope. Preserve the model and ISS assertion without treating missing current donor data as a false function. Propagation Review Root cause: UNRESOLVED Sources checked: RGD:70487 SOURCE STALE OR MISSING Resolved accession Q9WU82. No exact experimental term row in the captured current snapshot; check descendants and model provenance before treating this as a biological failure. Supporting Evidence: |
| GO:0061154 endothelial tube morphogenesis | IMP PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | KEEP AS NON CORE | Summary: endothelial tube morphogenesis: retain the positive contextual association or function. Reason: Downstream endothelial output of beta-catenin/LEF-1 signalling; kept as non-core. Supporting Evidence: |
| GO:0061549 sympathetic ganglion development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: sympathetic ganglion development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244541; references PMID:21325504. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0061549 sympathetic ganglion development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: sympathetic ganglion development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244541; references PMID:21325504. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0061550 cranial ganglion development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cranial ganglion development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244542; references PMID:11262227. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IDA PMID:12651860 The cohesin SMC3 is a target the for beta-catenin/TCF4 trans... | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IDA PMID:18193033 TBL1-TBLR1 and beta-catenin recruit each other to Wnt target... | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IDA PMID:18579517 LEF-1 negatively controls interleukin-4 expression through a... | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IEA GO_REF:0000107 | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244404, 417244405; references PMID:16678101, PMID:22665494. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:15905404 Functional interaction between beta-catenin and FOXO in oxid... | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:18936100 Dapper1 is a nucleocytoplasmic shuttling protein that negati... | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:19443654 MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated... | ACCEPT | Summary: RNA polymerase II-specific DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF (and FOXO, others) to coactivate their Pol II target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin PMID:15905404 beta-Catenin binds directly to FOXO and enhances FOXO transcriptional activity in mammalian cells |
| GO:0070062 extracellular exosome | HDA PMID:19199708 Proteomic analysis of human parotid gland exosomes by multid... | KEEP AS NON CORE | Summary: extracellular exosome: retain the positive contextual association or function. Reason: Cytoplasmic/junctional beta-catenin. Cytosolic protein (UniProt); cytosolic proteins, including abundant enzymes and cytoskeletal proteins, are expected and often promiscuous EV contents (MISEV2018 (PMID:30637094) category 2b). True, but not its core location. (Manual re-review for OMICS_EVIDENCE, 2026-10-10; previous action: MARK_AS_OVER_ANNOTATED.) Supporting Evidence: |
| GO:0070161 anchoring junction | IEA GO_REF:0000044 | ACCEPT | Summary: anchoring junction: supported at the stated source and biological scope. Reason: Adherens junctions are anchoring junctions. |
| GO:0070161 anchoring junction | ISS GO_REF:0000024 | ACCEPT | Summary: anchoring junction: supported at the stated source and biological scope. Reason: Adherens junctions are anchoring junctions. Curator transfer (ISS) from the dog (Canis lupus familiaris) ortholog. The current donor audit recovers B6V8E6: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:B6V8E6 SUPPORTS TRANSFER Resolved accession B6V8E6. Exact records 206398290; references PMID:10873669. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0070369 beta-catenin-TCF7L2 complex | IDA PMID:12651860 The cohesin SMC3 is a target the for beta-catenin/TCF4 trans... | ACCEPT | Summary: beta-catenin-TCF7L2 complex: supported at the stated source and biological scope. Reason: Stable nuclear beta-catenin-TCF4 (TCF7L2) complexes are constitutively active in APC-deficient colon cancer cells. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0070369 beta-catenin-TCF7L2 complex | IDA PMID:9065401 Constitutive transcriptional activation by a beta-catenin-Tc... | ACCEPT | Summary: beta-catenin-TCF7L2 complex: supported at the stated source and biological scope. Reason: The complete original abstract explicitly reports a stable nuclear beta-catenin/hTCF4 complex and beta-catenin-dependent transcription in human colon carcinoma cells. The current GO:0070369 definition names TCF7L2/TCF4 and cites PMID9065401. Retain the exact complex assertion while making clear that the original PDF was not recovered. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0070369 beta-catenin-TCF7L2 complex | IDA PMID:9065402 Activation of beta-catenin-Tcf signaling in colon cancer by ... | ACCEPT | Summary: beta-catenin-TCF7L2 complex: supported at the stated source and biological scope. Reason: Stable nuclear beta-catenin-TCF4 (TCF7L2) complexes are constitutively active in APC-deficient colon cancer cells. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0070411 I-SMAD binding | IPI PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | KEEP AS NON CORE | Summary: I-SMAD binding: retain the positive contextual association or function. Reason: Smad7 binds and stabilizes beta-catenin at E-cadherin complexes; correct but peripheral. Supporting Evidence: PMID:18593713 Smad7 increases the stabilized beta-catenin to form a complex with E-cadherin and stabilizes the E-cadherin-beta-catenin complex |
| GO:0070602 regulation of centromeric sister chromatid cohesion | IEA GO_REF:0000107 | MODIFY | Summary: regulation of centromeric sister chromatid cohesion: refine the term at the demonstrated source scope. Reason: The verified mouse experimental donor carries the same source-side term mismatch. Correct the human review interpretation to centriolar cohesion; preserve donor identity. Propagation Review Root cause: SOURCE BAD Sources checked: UniProtKB:Q02248 SOURCE BAD Resolved accession Q02248. Exact records 417244545; references PMID:20300119. Literal extensions retained; source experiments are not all claimed as personally read. The original sourceโs experimental scope is reassessed in the annotation reason. Proposed replacements: regulation of centriole-centriole cohesion Supporting Evidence: PMID:20300119 Wnt/ฮฒ-catenin signalling and conductin regulate centrosomal cohesion by altering the phosphorylation status of ฮฒ-catenin at the centrosomes |
| GO:0070602 regulation of centromeric sister chromatid cohesion | IMP PMID:20300119 Conductin/axin2 and Wnt signalling regulates centrosome cohe... | MODIFY | Summary: regulation of centromeric sister chromatid cohesion: refine the term at the demonstrated source scope. Reason: The complete original main experiments and Methods measure centrosome separation, supporting centriolar cohesion rather than chromosome-centromere cohesion. Proposed replacements: regulation of centriole-centriole cohesion Supporting Evidence: PMID:20300119 Wnt/ฮฒ-catenin signalling and conductin regulate centrosomal cohesion by altering the phosphorylation status of ฮฒ-catenin at the centrosomes |
| GO:0071363 cellular response to growth factor stimulus | IMP PMID:16858403 The inner nuclear membrane protein emerin regulates beta-cat... | KEEP AS NON CORE | Summary: cellular response to growth factor stimulus: retain the positive contextual association or function. Reason: Context-specific; kept as non-core. Supporting Evidence: |
| GO:0071664 catenin-TCF7L2 complex | IEA GO_REF:0000117 | ACCEPT | Summary: catenin-TCF7L2 complex: supported at the stated source and biological scope. Reason: Consistent with the established beta-catenin-TCF7L2 complex. The current rule genuinely matches ARBA00092110 branch(es) 0. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: NO FAILURE CORE Sources checked: ARBA:ARBA00092110 SUPPORTS TRANSFER Actual current matching condition branches 0; all predicates evaluated, with no unknown condition treated as true. Supporting Evidence: PMID:9065401 Nuclei of APC-/- colon carcinoma cells were found to contain a stable beta-catenin-hTcf-4 complex that was constitutively active |
| GO:0071681 cellular response to indole-3-methanol | IDA PMID:10868478 Suppression of breast cancer invasion and migration by indol... | MARK AS OVER ANNOTATED | Summary: cellular response to indole-3-methanol: the source supports a related observation but not the full attributed role. Reason: The original 24-hour indole-3-carbinol experiments measure increased alpha-, beta- and gamma-catenin protein abundance by Western blot in human MCF-7 and MDA-MB-468 cells. Anti-invasion effects are associated with an increased whole cadherinโcatenin complex, without isolating beta-cateninโs contribution to that response. The GO definition permits expression changes and does not require direct drug sensing; nevertheless, this source supports an expression association more securely than beta-catenin participation in the response. Retain the observation while marking this source-specific process attribution over-annotated. Supporting Evidence: PMID:10868478 three major catenins (alpha, beta, and gamma-catenin) |
| GO:0071681 cellular response to indole-3-methanol | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: cellular response to indole-3-methanol: the source supports a related observation but not the full attributed role. Reason: The original 24-hour indole-3-carbinol experiments measure increased alpha-, beta- and gamma-catenin protein abundance by Western blot in human MCF-7 and MDA-MB-468 cells. Anti-invasion effects are associated with an increased whole cadherinโcatenin complex, without isolating beta-cateninโs contribution to that response. The GO definition permits expression changes and does not require direct drug sensing; nevertheless, this source supports an expression association more securely than beta-catenin participation in the response. Retain the observation while marking this source-specific process attribution over-annotated. The current rule genuinely matches ARBA00092149 branch(es) 0. Matching a rule is distinct from validating its biological scope. Propagation Review Root cause: TERM SCOPING PROBLEM Sources checked: ARBA:ARBA00092149 UNRESOLVED Actual current matching condition branches 0; all predicates evaluated, with no unknown condition treated as true. Supporting Evidence: PMID:10868478 three major catenins (alpha, beta, and gamma-catenin) |
| GO:0071944 cell periphery | IDA PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone... | ACCEPT | Summary: cell periphery: supported at the stated source and biological scope. Reason: Consistent with membrane/junctional localization. Supporting Evidence: |
| GO:0072182 regulation of nephron tubule epithelial cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of nephron tubule epithelial cell differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244554; references PMID:19112489. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0072182 regulation of nephron tubule epithelial cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of nephron tubule epithelial cell differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244554; references PMID:19112489. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0072497 mesenchymal stem cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: mesenchymal stem cell differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244557; references PMID:30478225. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0072497 mesenchymal stem cell differentiation | IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m... | KEEP AS NON CORE | Summary: mesenchymal stem cell differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process supported at the stated reference and evidence-code scope. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Supporting Evidence: |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: negative regulation of canonical Wnt signaling pathway: the source supports a related observation but not the full attributed role. Reason: The exact mouse donor is the ComplexPortal IDA from PMID:10898789. The original Results and Discussion show ICAT disrupting beta-cateninโTCF association, reducing transcriptional reporter activity, and inhibiting Xenopus axis induction; the binding-defective and dominant-negative ICAT constructs test the inhibitor. Beta-catenin is the inhibited target in these experiments. Its association with ICAT does not itself establish that beta-catenin performs the negative regulatory step. The transferred process therefore overstates this particular evidence; this is not a claim that beta-catenin can never participate in negative feedback in another setting. Propagation Review Root cause: SOURCE BAD Sources checked: UniProtKB:Q02248 SOURCE BAD Resolved accession Q02248. Exact records 417244558; references PMID:10898789. Literal extensions retained; source experiments are not all claimed as personally read. The original sourceโs experimental scope is reassessed in the annotation reason. |
| GO:0090279 regulation of calcium ion import | IDA PMID:19996314 Cell-cell contact formation governs Ca2+ signaling by TRPC4 ... | KEEP AS NON CORE | Summary: regulation of calcium ion import: retain the positive contextual association or function. Reason: The original HMEC-1 experiments recover TRPC4 with beta-catenin and show contact-dependent junctional targeting. In HEK293 reconstitution, beta-catenin expression promotes TRPC4-dependent calcium entry in contact-forming cells but retains channel intracellularly in isolated cells. Preserve this conditional association/targeting role. Mouse TRPC4 constructs, human cell hosts and the authorsโ unresolved possibility of additional bridging scaffolds are distinct; the assays do not establish a purified binary interaction. Supporting Evidence: |
| GO:0090575 RNA polymerase II transcription regulator complex | IEA GO_REF:0000107 | ACCEPT | Summary: RNA polymerase II transcription regulator complex: supported at the stated source and biological scope. Reason: Beta-catenin-TCF/LEF complexes regulate Pol II target genes. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244856; references PMID:21075118. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0097091 synaptic vesicle clustering | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: synaptic vesicle clustering: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244562, 417244563; references PMID:14622577. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0097718 disordered domain specific binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: disordered domain specific binding: retain the positive contextual association or function. Reason: Many beta-catenin partners (TCF, APC, Axin, cadherin tails) bind its armadillo groove through intrinsically disordered segments; correct but kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244409, 417244410; references PMID:11121423. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0098609 cell-cell adhesion | IBA GO_REF:0000033 | ACCEPT | Summary: cell-cell adhesion: supported at the stated source and biological scope. Reason: PAINT node PTN001153077 (beta-catenin/armadillo/HMP-2 family). Cadherin-dependent cell-cell adhesion is supported experimentally for human beta-catenin. IBA from PAINT node PTN001153077 (beta-catenin/Armadillo family); human CTNNB1 among the sources reflects its own experimental support, as expected. The current PTHR45976 tree places the exact 781-residue human target PTN002511128 below the matching IBD at PTN001153077. Experimental descendant records, including human CTNNB1 where listed, ground this ancestral placement; a self donor is legitimate evidence, not circularity. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN001153077 SUPPORTS TRANSFER Exact term-matching current IBD lies on the human target path; taxon:6072 is the recorded placement, not an independently reconstructed origin date. MGI:MGI:88276 SUPPORTS TRANSFER Resolved to Q02248; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. WB:WBGene00001979 SOURCE STALE OR MISSING Resolved to O44326; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. UniProtKB:P14923 SUPPORTS TRANSFER Resolved to P14923; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. RGD:70487 SUPPORTS TRANSFER Resolved to Q9WU82; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. FB:FBgn0000117 SUPPORTS TRANSFER Resolved to P18824; 2 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. UniProtKB:P35222 SOURCE STALE OR MISSING Resolved to P35222; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. UniProtKB:Q8SPJ1 SOURCE STALE OR MISSING Resolved to Q8SPJ1; 0 exact-term experimental current record(s). Exact historical source support is not reconstructed by this current snapshot; this alone does not invalidate the on-path IBD. MGI:MGI:96650 SUPPORTS TRANSFER Resolved to Q02257; 1 exact-term experimental current record(s). Their complete qualifiers/extensions are retained in the audit; the original experiment was not necessarily personally reread. Supporting Evidence: PMID:11713476 The multifunctional protein beta-catenin is important for cell adhesion, because it binds cadherins |
| GO:0098685 Schaffer collateral - CA1 synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Schaffer collateral - CA1 synapse: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244595, 417244596; references PMID:14622577. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0098831 presynaptic active zone cytoplasmic component | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: presynaptic active zone cytoplasmic component: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244597, 417244598, 417244599, 417244600; references PMID:8909549. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: glutamatergic synapse: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244601, 417244602, 417244603, 417244604; references PMID:28641114. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0099092 postsynaptic density, intracellular component | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: postsynaptic density, intracellular component: retain the positive contextual association or function. Reason: Synaptic location transferred from rodent Ctnnb1. Beta-catenin is part of N-cadherin-catenin complexes at synapses; this is a tissue-specific instance of its junctional localization, kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 4 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244605, 417244606, 417244607, 417244608; references PMID:8909549. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:0140297 DNA-binding transcription factor binding | IEA GO_REF:0000107 | ACCEPT | Summary: DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF and other DNA-binding factors; this is how it reaches target genes. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244413, 417244414; references PMID:17331723, PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0140297 DNA-binding transcription factor binding | IPI PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | ACCEPT | Summary: DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF and other DNA-binding factors; this is how it reaches target genes. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:0140297 DNA-binding transcription factor binding | ISS GO_REF:0000024 | ACCEPT | Summary: DNA-binding transcription factor binding: supported at the stated source and biological scope. Reason: Beta-catenin binds TCF/LEF and other DNA-binding factors; this is how it reaches target genes. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244413, 417244414; references PMID:17331723, PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:1901331 positive regulation of odontoblast differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of odontoblast differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244566; references PMID:29148101. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244567; references PMID:21752258. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1904888 cranial skeletal system development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cranial skeletal system development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244568; references PMID:11262227. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1904948 midbrain dopaminergic neuron differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: midbrain dopaminergic neuron differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244569; references PMID:19122665. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1904948 midbrain dopaminergic neuron differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: midbrain dopaminergic neuron differentiation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244569; references PMID:19122665. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1905555 positive regulation of blood vessel branching | IMP PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | KEEP AS NON CORE | Summary: positive regulation of blood vessel branching: retain the positive contextual association or function. Reason: Downstream endothelial output of beta-catenin/LEF-1 signalling; kept as non-core. Supporting Evidence: |
| GO:1990138 neuron projection extension | IMP PMID:19830702 GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/bet... | KEEP AS NON CORE | Summary: neuron projection extension: retain the positive contextual association or function. Reason: Context-specific; kept as non-core. Supporting Evidence: |
| GO:1990226 histone methyltransferase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: histone methyltransferase binding: retain the positive contextual association or function. Reason: Beta-catenin recruits histone methyltransferase complexes (e.g. MLL/SET1-type) to Wnt targets; correct but non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244416; references PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1990226 histone methyltransferase binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: histone methyltransferase binding: retain the positive contextual association or function. Reason: Beta-catenin recruits histone methyltransferase complexes (e.g. MLL/SET1-type) to Wnt targets; correct but non-core. Curator transfer (ISS) from the rodent ortholog. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244416; references PMID:22723415. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1990403 embryonic brain development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: embryonic brain development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244576; references PMID:11262227. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1990711 beta-catenin-ICAT complex | IEA GO_REF:0000107 | ACCEPT | Summary: beta-catenin-ICAT complex: supported at the stated source and biological scope. Reason: ICAT binds the armadillo repeats of beta-catenin and blocks TCF binding; structurally defined. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244857; references PMID:10898789. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:12408824 We show that ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions |
| GO:1990791 dorsal root ganglion development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: dorsal root ganglion development: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244577; references PMID:11262227. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1990907 beta-catenin-TCF complex | IDA PMID:28296634 Constitutive scaffolding of multiple Wnt enhanceosome compon... | ACCEPT | Summary: beta-catenin-TCF complex: supported at the stated source and biological scope. Reason: The original human BCL9/B9L/PYGO BioID experiments, co-immunoprecipitations and Wnt-responsive reporters support beta-catenin association with the TCF enhanceosome. Wnt-dependent proximity changes distinguish beta-catenin docking from the constitutive BCL9/B9L scaffold. BioID proximity alone is not a purified binary contact, and fly genetic results are not represented as human experiments. Supporting Evidence: PMID:11955446 Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:1990907 beta-catenin-TCF complex | IEA GO_REF:0000107 | ACCEPT | Summary: beta-catenin-TCF complex: supported at the stated source and biological scope. Reason: The nuclear effector complex of canonical Wnt signalling. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 2 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244860, 417244861; references PMID:20371816, PMID:9488439. Literal extensions retained; source experiments are not all claimed as personally read. Supporting Evidence: PMID:11955446 Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:1990907 beta-catenin-TCF complex | IPI PMID:11955446 Wnt/wingless signaling requires BCL9/legless-mediated recrui... | ACCEPT | Summary: beta-catenin-TCF complex: supported at the stated source and biological scope. Reason: The current GO:1990907 definition specifies a beta-catenin complex containing a TCF/LEF-family member. The literal source includes P15884, whose alias ambiguity must remain explicit; the two matched PMID:11955446 interaction records establish BCL9 associations, not a resolved P15884 pair. Nevertheless, human beta-catenin/TCF-LEF complex biology is independently demonstrated by the recovered PMID:17875931 experiments and the previously read human LEF1 chromatin-complex experiments in PMID:11751639. Retain the biologically correct complex annotation without treating the P15884 label as verified, imposing fixed stoichiometry, or asserting that every member directly contacts every other member. Supporting Evidence: PMID:11955446 Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:1990907 beta-catenin-TCF complex | IPI PMID:18936100 Dapper1 is a nucleocytoplasmic shuttling protein that negati... | ACCEPT | Summary: beta-catenin-TCF complex: supported at the stated source and biological scope. Reason: The nuclear effector complex of canonical Wnt signalling. Supporting Evidence: PMID:11955446 Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:1990907 beta-catenin-TCF complex | IPI PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | ACCEPT | Summary: beta-catenin-TCF complex: supported at the stated source and biological scope. Reason: The nuclear effector complex of canonical Wnt signalling. Supporting Evidence: PMID:11955446 Wnt transduction is mediated by the association of beta-catenin with nuclear TCF DNA binding factors PMID:9065401 hTcf-4 transactivates transcription only when associated with beta-catenin |
| GO:1990909 Wnt signalosome | IEA GO_REF:0000107 | UNDECIDED | Summary: Wnt signalosome: the specific source or functional scope remains unresolved. Reason: The exact mouse IDA donor from PMID:22899650 is retained. Its original experiments identify beta-catenin in an endogenous LRRK2-containing cytosolic complex, whereas the membrane-recruitment and receptor-binding assays directly examine LRRK2. The signalosome model and the same authorsโ later review (PMID:24115276) include recruitment of beta-catenin-containing machinery, but do not resolve which target-specific observation supports the part-of assertion. GO:1990909 permits additional cytosolic components, so a blanket exclusion of beta-catenin is unwarranted. Leave membership undecided pending clarification of the experimental complex boundary; absence from an inspected assay is not evidence of absence. Propagation Review Root cause: UNRESOLVED Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244862; references PMID:22899650. Literal extensions retained; source experiments are not all claimed as personally read. |
| GO:1990909 Wnt signalosome | NAS PMID:24115276 The regulation and deregulation of Wnt signaling by PARK gen... | UNDECIDED | Summary: Wnt signalosome: the specific source or functional scope remains unresolved. Reason: The NAS review presents beta-catenin recruitment in an LRRK2/Wnt-receptor model. The corresponding original co-immunoprecipitation supports a cytosolic LRRK2โbeta-catenin/destruction-complex association, while receptor-membrane experiments concern LRRK2. These data do not settle direct beta-catenin membership in the receptor-associated Wnt signalosome. The term definition does not exclude beta-catenin categorically; retain the positive association and leave this complex assignment unresolved. Supporting Evidence: |
| GO:2000008 regulation of protein localization to cell surface | IDA PMID:19996314 Cell-cell contact formation governs Ca2+ signaling by TRPC4 ... | KEEP AS NON CORE | Summary: regulation of protein localization to cell surface: retain the positive contextual association or function. Reason: The original HMEC-1 experiments recover TRPC4 with beta-catenin and show contact-dependent junctional targeting. In HEK293 reconstitution, beta-catenin expression promotes TRPC4-dependent calcium entry in contact-forming cells but retains channel intracellularly in isolated cells. Preserve this conditional association/targeting role. Mouse TRPC4 constructs, human cell hosts and the authorsโ unresolved possibility of additional bridging scaffolds are distinct; the assays do not establish a purified binary interaction. Supporting Evidence: |
| GO:2000179 positive regulation of neural precursor cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of neural precursor cell proliferation: retain the positive contextual association or function. Reason: Developmental or tissue-level process transferred from mouse Ctnnb1. Beta-catenin acts in such processes through Wnt/TCF-dependent transcription or cadherin adhesion; the term describes a downstream, animal-specific context rather than its core activity, so it is kept as non-core. Electronic transfer from mouse Ctnnb1 (Q02248) via Ensembl Compara. The current donor audit recovers Q02248: 1 exact experimental source record(s). Biological support and the sourceโs tissue/assay scope are kept separate. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: UniProtKB:Q02248 SUPPORTS TRANSFER Resolved accession Q02248. Exact records 417244581; references PMID:26371318. Literal extensions retained; source experiments are not all claimed as personally read. |
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Download this section (compressed HTML)Q: Can the TCF4 interaction records be reconciled at clone/accession level between E2-2 (P15884) and TCF7L2 (Q9NQB0), preserving the originally curated partner while resolving historical aliases?
Q: Which below-quantification beta-catenin PDZ-screen records represent reproducible weak interactions, and which positive alternate-domain measurements can be validated with the exact native protein products?
Q: Does beta-catenin make an experimentally separable contribution to hippocampal LTD in the GO-CAM context, beyond the PTEN-associated transcriptional changes in the currently inspected source?
Q: How do beta-cateninโs junctional and transcriptional interaction surfaces contribute to mechanical responses in human tissues, distinct from the conserved molecular mechanism measured in fly experiments?
Experiment: Validate the measured and marginal PDZ contacts with defined domains and full-length proteins, then test whether disrupting the beta-catenin terminal motif changes association or localization in a relevant human cell type. Keep below-quantification records distinct from established noninteractions.
Hypothesis: Selected beta-catenin C-terminal PDZ contacts are retained in the exact full-length partner context.
Type: quantitative binding and cellular interaction assays
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