CUL3

UniProt ID: Q13618
Organism: Homo sapiens
Review Status: INITIALIZED
πŸ“ Provide Detailed Feedback

Gene Description

TODO: Add description for CUL3

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005634 nucleus
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000209 protein polyubiquitination
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000278 mitotic cell cycle
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000922 spindle pole
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005813 centrosome
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005819 spindle
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006915 apoptotic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006950 response to stress
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010468 regulation of gene expression
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031461 cullin-RING ubiquitin ligase complex
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031514 motile cilium
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098794 postsynapse
IEA
GO_REF:0000108 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12609982
TIP120A associates with cullins and modulates ubiquitin liga... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:17543862
A Cul3-based E3 ligase removes Aurora B from mitotic chromos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18775313
UBXD7 binds multiple ubiquitin ligases and implicates p97 in... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18850735
Characterization of the human COP9 signalosome complex using... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19427028
Cullin3-based polyubiquitination and p62-dependent aggregati... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19615732
Defining the human deubiquitinating enzyme interaction lands... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19617556
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20389280
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquiti... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20554658
Kelch-like homologue 9 mutation is associated with an early ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20562859
Network organization of the human autophagy system. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21145461
Dynamics of cullin-RING ubiquitin ligase network revealed by... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21577200
Tumor-suppressor role for the SPOP ubiquitin ligase in signa... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21828050
Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuate... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21988832
Toward an understanding of the protein interaction network o... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22466964
NEDD8 links cullin-RING ubiquitin ligase function to the p97... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22542517
KBTBD13 interacts with Cullin 3 to form a functional ubiquit... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22632832
Adaptor protein self-assembly drives the control of a cullin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22939624
Quantitative analysis of HSP90-client interactions reveals p... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23563313
CCDC22 deficiency in humans blunts activation of proinflamma... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23665031
Disease-causing mutations in KLHL3 impair its effect on WNK4... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25502805
A massively parallel pipeline to clone DNA variants and exam... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25619834
KLHL39 suppresses colon cancer metastasis by blocking KLHL20... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25684205
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26949739
Identification of Human Neuronal Protein Complexes Reveals B... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:27152988
The BTB domains of the potassium channel tetramerization dom... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:30190310
Dimerization quality control ensures neuronal development an... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:31515488
Extensive disruption of protein interactions by genetic vari... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:31652307
Kelch-like protein 5-mediated ubiquitination of lysine 183 p... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:34591642
A protein network map of head and neck cancer reveals PIK3CA... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:35512704
Systematic discovery of mutation-directed neo-protein-protei... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:37207277
Using brain cell-type-specific protein interactomes to inter... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:37788672
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligom... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:38225382
Systematic discovery of protein interaction interfaces using... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001822 kidney development
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006954 inflammatory response
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007229 integrin-mediated signaling pathway
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0010467 gene expression
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017145 stem cell division
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030163 protein catabolic process
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030332 cyclin binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0040016 embryonic cleavage
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0042802 identical protein binding
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0098978 glutamatergic synapse
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140252 regulation protein catabolic process at postsynapse
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:22542517
KBTBD13 interacts with Cullin 3 to form a functional ubiquit... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:22632832
Adaptor protein self-assembly drives the control of a cullin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:25684205
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:26399832
Cell-fate determination by ubiquitin-dependent regulation of... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:29249570
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mam... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:29249570
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mam... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:31898230
CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:37628845
The Role of PIK3R1 in Metabolic Function and Insulin Sensiti... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:37788672
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligom... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IDA
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0015630 microtubule cytoskeleton
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005794 Golgi apparatus
IDA
PMID:24145166
Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:29769719
KLHL22 activates amino-acid-dependent mTORC1 signalling to p... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IDA
PMID:15601839
BTB protein Keap1 targets antioxidant transcription factor N... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15107402
RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligas... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IDA
PMID:23453970
Impaired KLHL3-mediated ubiquitination of WNK4 causes human ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:35862218
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocort... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:35687106
ARMC5 is part of an RPB1-specific ubiquitin ligase implicate... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:38225631
ARMC5 controls the degradation of most Pol II subunits, and ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:39504960
Redundant pathways for removal of defective RNA polymerase I... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:39667934
CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:35687106
ARMC5 is part of an RPB1-specific ubiquitin ligase implicate... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:38225631
ARMC5 controls the degradation of most Pol II subunits, and ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:39504960
Redundant pathways for removal of defective RNA polymerase I... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:39667934
CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034599 cellular response to oxidative stress
IDA
PMID:15601839
BTB protein Keap1 targets antioxidant transcription factor N... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:15601839
BTB protein Keap1 targets antioxidant transcription factor N... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071230 cellular response to amino acid stimulus
IDA
PMID:29769719
KLHL22 activates amino-acid-dependent mTORC1 signalling to p... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IDA
PMID:29769719
KLHL22 activates amino-acid-dependent mTORC1 signalling to p... 		PENDING
Summary: TODO: Review this GOA annotation
GO:1904263 positive regulation of TORC1 signaling
IDA
PMID:29769719
KLHL22 activates amino-acid-dependent mTORC1 signalling to p... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:23453970
Impaired KLHL3-mediated ubiquitination of WNK4 causes human ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:27708159
Insulin resistance and diabetes caused by genetic or diet-in... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070936 protein K48-linked ubiquitination
IDA
PMID:27708159
Insulin resistance and diabetes caused by genetic or diet-in... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IDA
PMID:27708159
Insulin resistance and diabetes caused by genetic or diet-in... 		PENDING
Summary: TODO: Review this GOA annotation
GO:1900076 regulation of cellular response to insulin stimulus
IDA
PMID:27708159
Insulin resistance and diabetes caused by genetic or diet-in... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032480 negative regulation of type I interferon production
IDA
PMID:36394357
XAF1 prevents hyperproduction of type I interferon upon vira... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0160072 ubiquitin ligase complex scaffold activity
IDA
PMID:36394357
XAF1 prevents hyperproduction of type I interferon upon vira... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IMP
PMID:25684205
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070936 protein K48-linked ubiquitination
IDA
PMID:25684205
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:25684205
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:28169274
Armc5 deletion causes developmental defects and compromises ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005886 plasma membrane
IDA
PMID:19617556
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26906416
Characterization of the mammalian family of DCN-type NEDD8 E... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:24192928
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylatio... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000209 protein polyubiquitination
IDA
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IPI
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051865 protein autoubiquitination
IDA
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061630 ubiquitin protein ligase activity
IDA
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031208 POZ domain binding
IDA
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000922 spindle pole
IDA
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IDA
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005813 centrosome
IDA
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0072686 mitotic spindle
IDA
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:1901992 positive regulation of mitotic cell cycle phase transition
IMP
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquityl... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:29276004
Missense Variants in RHOBTB2 Cause a Developmental and Epile... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:28395323
Defining the human sperm microtubulome: an integrated genomi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0036126 sperm flagellum
IDA
PMID:28395323
Defining the human sperm microtubulome: an integrated genomi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031398 positive regulation of protein ubiquitination
IGI
PMID:24844779
Hypoxia-responsive microRNA-101 promotes angiogenesis via he... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031648 protein destabilization
IGI
PMID:24844779
Hypoxia-responsive microRNA-101 promotes angiogenesis via he... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22748208
A homozygous mutation in KCTD7 links neuronal ceroid lipofus... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23776465
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear lo... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:26399832
Cell-fate determination by ubiquitin-dependent regulation of... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8932327 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952631 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8956040 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9712274 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9755505 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9755507 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9758090 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9759169 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9759172 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9766645 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9766656 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9766677 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9766687 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005112 Notch binding
IPI
PMID:25401743
KCTD10 is involved in the cardiovascular system and Notch si... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
IDA
PMID:25401743
KCTD10 is involved in the cardiovascular system and Notch si... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26334369
Structural Insights into KCTD Protein Assembly and Cullin3 R... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:27561354
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnov... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006511 ubiquitin-dependent protein catabolic process
IDA
PMID:27561354
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnov... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system
IDA
PMID:27561354
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnov... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031145 anaphase-promoting complex-dependent catabolic process
IDA
PMID:10500095
Cullin-3 targets cyclin E for ubiquitination and controls S ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25270598
Ubiquitin-proteasome system controls ciliogenesis at the ini... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21778237
COMMD1 (copper metabolism MURR1 domain-containing protein 1)... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5635854 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5635855 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-5635856 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007080 mitotic metaphase chromosome alignment
IMP
PMID:17543862
A Cul3-based E3 ligase removes Aurora B from mitotic chromos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007080 mitotic metaphase chromosome alignment
IMP
PMID:19995937
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midz... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
IMP
PMID:17543862
A Cul3-based E3 ligase removes Aurora B from mitotic chromos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:24768539
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20Β Ub... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
HDA
PMID:19946888
Defining the membrane proteome of NK cells. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070062 extracellular exosome
HDA
PMID:19056867
Large-scale proteomics and phosphoproteomics of urinary exos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:19158078
Control of rapsyn stability by the CUL-3-containing E3 ligas... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:22578813
Translational homeostasis via the mRNA cap-binding protein, ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:23453970
Impaired KLHL3-mediated ubiquitination of WNK4 causes human ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:23576762
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis v... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18397884
Regulation of TIP60 by ATF2 modulates ATM activation. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1504190 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1504193 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1504213 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-5658424 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952630 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8955241 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8955289 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9018778 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9018787 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9706390 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9929484 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9929486 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9929490 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:23455478
Ubiquitylation-dependent localization of PLK1 in mitosis. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000209 protein polyubiquitination
IDA
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031208 POZ domain binding
IDA
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032467 positive regulation of cytokinesis
IMP
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is requi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:15983046
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor prote... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:15983046
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor prote... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006513 protein monoubiquitination
IDA
PMID:22358839
Ubiquitin-dependent regulation of COPII coat size and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
IDA
PMID:22358839
Ubiquitin-dependent regulation of COPII coat size and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007229 integrin-mediated signaling pathway
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0017145 stem cell division
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:22358839
Ubiquitin-dependent regulation of COPII coat size and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0040016 embryonic cleavage
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0048208 COPII vesicle coating
IMP
PMID:22358839
Ubiquitin-dependent regulation of COPII coat size and functi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18826954
SCCRO (DCUN1D1) is an essential component of the E3 complex ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016477 cell migration
IMP
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0035024 negative regulation of Rho protein signal transduction
IMP
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043149 stress fiber assembly
IMP
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily c... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
IDA
PMID:20389280
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquiti... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004842 ubiquitin-protein transferase activity
IDA
PMID:20389280
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquiti... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005827 polar microtubule
IDA
PMID:19995937
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midz... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:17543862
A Cul3-based E3 ligase removes Aurora B from mitotic chromos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:19995937
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midz... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IDA
PMID:20389280
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquiti... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:17543862
A Cul3-based E3 ligase removes Aurora B from mitotic chromos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:19995937
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midz... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031463 Cul3-RING ubiquitin ligase complex
IDA
PMID:20389280
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquiti... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18573101
KCTD5, a putative substrate adaptor for cullin3 ubiquitin li... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000082 G1/S transition of mitotic cell cycle
TAS
PMID:8681378
cul-1 is required for cell cycle exit in C. elegans and iden... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008284 positive regulation of cell population proliferation
TAS
PMID:9733711
Cloning and expression analysis of a novel salicylate suppre... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0097193 intrinsic apoptotic signaling pathway
TAS
PMID:8681378
cul-1 is required for cell cycle exit in C. elegans and iden... 		PENDING
Summary: TODO: Review this GOA annotation

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10500095
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.
PMID:12609982
TIP120A associates with cullins and modulates ubiquitin ligase activity.
PMID:14528312
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
PMID:15107402
RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex.
PMID:15601839
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
PMID:15983046
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.
PMID:17543862
A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells.
PMID:18397884
Regulation of TIP60 by ATF2 modulates ATM activation.
PMID:18573101
KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases.
PMID:18775313
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
PMID:18826954
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
PMID:18850735
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
PMID:19056867
Large-scale proteomics and phosphoproteomics of urinary exosomes.
PMID:19158078
Control of rapsyn stability by the CUL-3-containing E3 ligase complex.
PMID:19261606
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
PMID:19427028
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling.
PMID:19615732
Defining the human deubiquitinating enzyme interaction landscape.
PMID:19617556
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
PMID:19782033
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
PMID:19946888
Defining the membrane proteome of NK cells.
PMID:19995937
The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
PMID:20389280
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses.
PMID:20554658
Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.
PMID:20562859
Network organization of the human autophagy system.
PMID:21145461
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
PMID:21577200
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.
PMID:21778237
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
PMID:21828050
Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22358839
Ubiquitin-dependent regulation of COPII coat size and function.
PMID:22466964
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
PMID:22542517
KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase.
PMID:22578813
Translational homeostasis via the mRNA cap-binding protein, eIF4E.
PMID:22632832
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.
PMID:22748208
A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.
PMID:22939624
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
PMID:23213400
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
PMID:23453970
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
PMID:23455478
Ubiquitylation-dependent localization of PLK1 in mitosis.
PMID:23563313
CCDC22 deficiency in humans blunts activation of proinflammatory NF-ΞΊB signaling.
PMID:23576762
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
PMID:23665031
Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
PMID:23776465
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.
PMID:24145166
Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression.
PMID:24192928
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.
PMID:24768539
K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20Β Ubiquitin E3 Ligase Regulates Protein Trafficking.
PMID:24844779
Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3.
PMID:25270598
Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension.
PMID:25401743
KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:25502805
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
PMID:25619834
KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.
PMID:25684205
CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
PMID:26334369
Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
PMID:26399832
Cell-fate determination by ubiquitin-dependent regulation of translation.
PMID:26906416
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
PMID:26949739
Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.
PMID:27152988
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
PMID:27561354
Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.
PMID:27708159
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
PMID:28169274
Armc5 deletion causes developmental defects and compromises T-cell immune responses.
PMID:28395323
Defining the human sperm microtubulome: an integrated genomics approach.
PMID:29249570
Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
PMID:29276004
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
PMID:29769719
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
PMID:30190310
Dimerization quality control ensures neuronal development and survival.
PMID:31515488
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
PMID:31652307
Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal degradation of sphingosine kinase 1.
PMID:31898230
CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:34591642
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
PMID:35512704
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:35687106
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
PMID:35862218
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.
PMID:36394357
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
PMID:37207277
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
PMID:37628845
The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.
PMID:37788672
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
PMID:38225382
Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation.
PMID:38225631
ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
PMID:39504960
Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint.
PMID:39667934
CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription.
PMID:40205054
Multimodal cell maps as a foundation for structural and functional genomics.
PMID:8681378
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
PMID:9733711
Cloning and expression analysis of a novel salicylate suppressible gene, Hs-CUL-3, a member of cullin/Cdc53 family.
Reactome:R-HSA-1504190
DVL is ubiquitinated by CUL3:KLHL12:RBX1
Reactome:R-HSA-1504193
Ubiquitinated DVL is degraded by the proteasome
Reactome:R-HSA-1504213
DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
Reactome:R-HSA-5635854
GLI2,3 are degraded by the proteasome
Reactome:R-HSA-5635855
phosphorylated GLI proteins bind SPOP:CUL3:RBX1
Reactome:R-HSA-5635856
SPOP:CUL3:RBX1 ubiquitinates GLI2,3
Reactome:R-HSA-5658424
KBTBD7:CUL3:RBX1 ubiquitinates NF1
Reactome:R-HSA-8932327
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
Reactome:R-HSA-8952630
NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex
Reactome:R-HSA-8952631
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex
Reactome:R-HSA-8955241
CAND1 binds cytosolic CRL E3 ubiquitin ligases
Reactome:R-HSA-8955289
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
Reactome:R-HSA-8956040
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
Reactome:R-HSA-9018778
RHOBTB1 binds interacting proteins at the endosome membrane
Reactome:R-HSA-9018787
RHOBTB2 binds interacting proteins at the endosome membrane
Reactome:R-HSA-9706390
RHOBTB3 binds interacting proteins at trans-Golgi network
Reactome:R-HSA-9712274
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
Reactome:R-HSA-9755505
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
Reactome:R-HSA-9755507
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
Reactome:R-HSA-9758090
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
Reactome:R-HSA-9759169
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
Reactome:R-HSA-9759172
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
Reactome:R-HSA-9766645
CUL3:RBX1 ubiquitinates KEAP1
Reactome:R-HSA-9766656
RBX1:CUL3 dissociates from forming autophagosome
Reactome:R-HSA-9766677
MAP1LC3B binds KEAP1 and SQSTM1
Reactome:R-HSA-9766687
SESN1,SESN1 bind SQSTM1 and KEAP1
Reactome:R-HSA-9929484
SPOP:CUL3:RBX1 binds to CD274
Reactome:R-HSA-9929486
SPOP-mediated degradation of CD274 by 26S Proteosome
Reactome:R-HSA-9929490
CD274 ubiquitination by SPOP:CUL3:RBX1 complex

πŸ“„ View Raw YAML

 
id: Q13618
gene_symbol: CUL3
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for CUL3'
alternative_products:
- name: 1 (Cul-3 Long)
  id: Q13618-1
- name: '2'
  id: Q13618-2
  sequence_note: VSP_008824
- name: 3 (Cul-3 Short)
  id: Q13618-3
  sequence_note: VSP_008825
existing_annotations:
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000209
    label: protein polyubiquitination
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000278
    label: mitotic cell cycle
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000922
    label: spindle pole
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005813
    label: centrosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005819
    label: spindle
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006915
    label: apoptotic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006950
    label: response to stress
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007165
    label: signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010468
    label: regulation of gene expression
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031461
    label: cullin-RING ubiquitin ligase complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031514
    label: motile cilium
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098794
    label: postsynapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12609982
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17543862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18775313
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18850735
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19427028
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19615732
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19617556
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20389280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20554658
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20562859
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21145461
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21577200
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21828050
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21988832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22466964
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22542517
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22632832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22939624
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23563313
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23665031
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25416956
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25502805
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25619834
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25684205
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26949739
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27152988
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:30190310
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31515488
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31652307
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32296183
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32814053
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:34591642
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35512704
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37207277
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:37788672
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:38225382
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001822
    label: kidney development
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006954
    label: inflammatory response
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007229
    label: integrin-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0010467
    label: gene expression
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0017145
    label: stem cell division
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030163
    label: protein catabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030332
    label: cyclin binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0040016
    label: embryonic cleavage
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0042802
    label: identical protein binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140252
    label: regulation protein catabolic process at postsynapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:22542517
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:22632832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:25684205
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:26399832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:29249570
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:29249570
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:31898230
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:37628845
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:37788672
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IDA
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0015630
    label: microtubule cytoskeleton
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005794
    label: Golgi apparatus
  evidence_type: IDA
  original_reference_id: PMID:24145166
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:29769719
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IDA
  original_reference_id: PMID:15601839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15107402
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IDA
  original_reference_id: PMID:23453970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:35862218
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:35687106
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:38225631
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:39504960
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:39667934
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:35687106
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:38225631
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:39504960
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:39667934
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0034599
    label: cellular response to oxidative stress
  evidence_type: IDA
  original_reference_id: PMID:15601839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:15601839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071230
    label: cellular response to amino acid stimulus
  evidence_type: IDA
  original_reference_id: PMID:29769719
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IDA
  original_reference_id: PMID:29769719
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1904263
    label: positive regulation of TORC1 signaling
  evidence_type: IDA
  original_reference_id: PMID:29769719
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:23453970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:27708159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070936
    label: protein K48-linked ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:27708159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IDA
  original_reference_id: PMID:27708159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1900076
    label: regulation of cellular response to insulin stimulus
  evidence_type: IDA
  original_reference_id: PMID:27708159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032480
    label: negative regulation of type I interferon production
  evidence_type: IDA
  original_reference_id: PMID:36394357
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0160072
    label: ubiquitin ligase complex scaffold activity
  evidence_type: IDA
  original_reference_id: PMID:36394357
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IMP
  original_reference_id: PMID:25684205
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070936
    label: protein K48-linked ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:25684205
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:25684205
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28169274
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:19617556
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26906416
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24192928
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000209
    label: protein polyubiquitination
  evidence_type: IDA
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IPI
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0051865
    label: protein autoubiquitination
  evidence_type: IDA
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0061630
    label: ubiquitin protein ligase activity
  evidence_type: IDA
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031208
    label: POZ domain binding
  evidence_type: IDA
  original_reference_id: PMID:14528312
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000922
    label: spindle pole
  evidence_type: IDA
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005813
    label: centrosome
  evidence_type: IDA
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0072686
    label: mitotic spindle
  evidence_type: IDA
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1901992
    label: positive regulation of mitotic cell cycle phase transition
  evidence_type: IMP
  original_reference_id: PMID:23213400
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29276004
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:28395323
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0036126
    label: sperm flagellum
  evidence_type: IDA
  original_reference_id: PMID:28395323
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031398
    label: positive regulation of protein ubiquitination
  evidence_type: IGI
  original_reference_id: PMID:24844779
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031648
    label: protein destabilization
  evidence_type: IGI
  original_reference_id: PMID:24844779
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22748208
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23776465
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:26399832
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8932327
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952631
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956040
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9712274
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755505
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755507
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9758090
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9759169
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9759172
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9766645
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9766656
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9766677
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9766687
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005112
    label: Notch binding
  evidence_type: IPI
  original_reference_id: PMID:25401743
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:25401743
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26334369
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27561354
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006511
    label: ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:27561354
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0071630
    label: nuclear protein quality control by the ubiquitin-proteasome system
  evidence_type: IDA
  original_reference_id: PMID:27561354
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031145
    label: anaphase-promoting complex-dependent catabolic process
  evidence_type: IDA
  original_reference_id: PMID:10500095
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25270598
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21778237
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635854
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635855
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5635856
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007080
    label: mitotic metaphase chromosome alignment
  evidence_type: IMP
  original_reference_id: PMID:17543862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007080
    label: mitotic metaphase chromosome alignment
  evidence_type: IMP
  original_reference_id: PMID:19995937
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0045842
    label: positive regulation of mitotic metaphase/anaphase transition
  evidence_type: IMP
  original_reference_id: PMID:17543862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:24768539
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016020
    label: membrane
  evidence_type: HDA
  original_reference_id: PMID:19946888
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070062
    label: extracellular exosome
  evidence_type: HDA
  original_reference_id: PMID:19056867
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:19158078
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:22578813
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:23453970
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:23576762
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18397884
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1504190
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1504193
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1504213
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5658424
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952630
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8955241
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8955289
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9018778
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9018787
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9706390
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929484
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929486
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929490
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:23455478
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000209
    label: protein polyubiquitination
  evidence_type: IDA
  original_reference_id: PMID:19261606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:19261606
  qualifier: contributes_to
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19261606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031208
    label: POZ domain binding
  evidence_type: IDA
  original_reference_id: PMID:19261606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:19261606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032467
    label: positive regulation of cytokinesis
  evidence_type: IMP
  original_reference_id: PMID:19261606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:19261606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:15983046
  qualifier: contributes_to
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:15983046
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006513
    label: protein monoubiquitination
  evidence_type: IDA
  original_reference_id: PMID:22358839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006888
    label: endoplasmic reticulum to Golgi vesicle-mediated transport
  evidence_type: IDA
  original_reference_id: PMID:22358839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0007229
    label: integrin-mediated signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0017145
    label: stem cell division
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:22358839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0040016
    label: embryonic cleavage
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0048208
    label: COPII vesicle coating
  evidence_type: IMP
  original_reference_id: PMID:22358839
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18826954
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:19782033
  qualifier: contributes_to
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016477
    label: cell migration
  evidence_type: IMP
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0035024
    label: negative regulation of Rho protein signal transduction
  evidence_type: IMP
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043149
    label: stress fiber assembly
  evidence_type: IMP
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:19782033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: IDA
  original_reference_id: PMID:20389280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0004842
    label: ubiquitin-protein transferase activity
  evidence_type: IDA
  original_reference_id: PMID:20389280
  qualifier: contributes_to
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005827
    label: polar microtubule
  evidence_type: IDA
  original_reference_id: PMID:19995937
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:17543862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:19995937
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:20389280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:17543862
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:19995937
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031463
    label: Cul3-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:20389280
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18573101
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000082
    label: G1/S transition of mitotic cell cycle
  evidence_type: TAS
  original_reference_id: PMID:8681378
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0008284
    label: positive regulation of cell population proliferation
  evidence_type: TAS
  original_reference_id: PMID:9733711
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0097193
    label: intrinsic apoptotic signaling pathway
  evidence_type: TAS
  original_reference_id: PMID:8681378
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on inter-ontology
    links
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10500095
  title: Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian
    cells.
  findings: []
- id: PMID:12609982
  title: TIP120A associates with cullins and modulates ubiquitin ligase activity.
  findings: []
- id: PMID:14528312
  title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
  findings: []
- id: PMID:15107402
  title: RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex.
  findings: []
- id: PMID:15601839
  title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination
    by the Cullin 3-Roc1 ligase.
  findings: []
- id: PMID:15983046
  title: Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3,
    targets Keap1 for degradation by a proteasome-independent pathway.
  findings: []
- id: PMID:17543862
  title: A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating
    mitotic progression and completion of cytokinesis in human cells.
  findings: []
- id: PMID:18397884
  title: Regulation of TIP60 by ATF2 modulates ATM activation.
  findings: []
- id: PMID:18573101
  title: KCTD5, a putative substrate adaptor for cullin3 ubiquitin ligases.
  findings: []
- id: PMID:18775313
  title: UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
  findings: []
- id: PMID:18826954
  title: SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
  findings: []
- id: PMID:18850735
  title: Characterization of the human COP9 signalosome complex using affinity purification
    and mass spectrometry.
  findings: []
- id: PMID:19056867
  title: Large-scale proteomics and phosphoproteomics of urinary exosomes.
  findings: []
- id: PMID:19158078
  title: Control of rapsyn stability by the CUL-3-containing E3 ligase complex.
  findings: []
- id: PMID:19261606
  title: The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal
    mitosis in mammalian cells.
  findings: []
- id: PMID:19427028
  title: Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8
    mediate extrinsic apoptosis signaling.
  findings: []
- id: PMID:19615732
  title: Defining the human deubiquitinating enzyme interaction landscape.
  findings: []
- id: PMID:19617556
  title: The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
  findings: []
- id: PMID:19782033
  title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB
    adaptors to control actin cytoskeleton structure and cell movement.
  findings: []
- id: PMID:19946888
  title: Defining the membrane proteome of NK cells.
  findings: []
- id: PMID:19995937
  title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules
    in anaphase and is required for cytokinesis.
  findings: []
- id: PMID:20389280
  title: The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control
    interferon responses.
  findings: []
- id: PMID:20554658
  title: Kelch-like homologue 9 mutation is associated with an early onset autosomal
    dominant distal myopathy.
  findings: []
- id: PMID:20562859
  title: Network organization of the human autophagy system.
  findings: []
- id: PMID:21145461
  title: Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative
    proteomics.
  findings: []
- id: PMID:21577200
  title: Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis
    of the oncogenic co-activator SRC-3/AIB1.
  findings: []
- id: PMID:21778237
  title: COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin
    RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein
    1) binding.
  findings: []
- id: PMID:21828050
  title: Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal
    dominant retinitis pigmentosa causative mutation.
  findings: []
- id: PMID:21988832
  title: Toward an understanding of the protein interaction network of the human liver.
  findings: []
- id: PMID:22358839
  title: Ubiquitin-dependent regulation of COPII coat size and function.
  findings: []
- id: PMID:22466964
  title: NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
  findings: []
- id: PMID:22542517
  title: KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase.
  findings: []
- id: PMID:22578813
  title: Translational homeostasis via the mRNA cap-binding protein, eIF4E.
  findings: []
- id: PMID:22632832
  title: Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin
    ligase.
  findings: []
- id: PMID:22748208
  title: A homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the
    ubiquitin-proteasome system.
  findings: []
- id: PMID:22939624
  title: Quantitative analysis of HSP90-client interactions reveals principles of
    substrate recognition.
  findings: []
- id: PMID:23213400
  title: The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
  findings: []
- id: PMID:23453970
  title: Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.
  findings: []
- id: PMID:23455478
  title: Ubiquitylation-dependent localization of PLK1 in mitosis.
  findings: []
- id: PMID:23563313
  title: CCDC22 deficiency in humans blunts activation of proinflammatory NF-ΞΊB signaling.
  findings: []
- id: PMID:23576762
  title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination
    and degradation of WNK4.
  findings: []
- id: PMID:23665031
  title: Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.
  findings: []
- id: PMID:23776465
  title: Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through
    Nedd8 modification.
  findings: []
- id: PMID:24145166
  title: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes
    cell cycle progression.
  findings: []
- id: PMID:24192928
  title: Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity
    and nuclear localization.
  findings: []
- id: PMID:24768539
  title: K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20Β Ubiquitin E3 Ligase
    Regulates Protein Trafficking.
  findings: []
- id: PMID:24844779
  title: Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular
    endothelial growth factor axis by targeting cullin 3.
  findings: []
- id: PMID:25270598
  title: Ubiquitin-proteasome system controls ciliogenesis at the initial step of
    axoneme extension.
  findings: []
- id: PMID:25401743
  title: KCTD10 is involved in the cardiovascular system and Notch signaling during
    early embryonic development.
  findings: []
- id: PMID:25416956
  title: A proteome-scale map of the human interactome network.
  findings: []
- id: PMID:25502805
  title: A massively parallel pipeline to clone DNA variants and examine molecular
    phenotypes of human disease mutations.
  findings: []
- id: PMID:25619834
  title: KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML
    and DAPK ubiquitination.
  findings: []
- id: PMID:25684205
  title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially
    restrict TIAM1-RAC1 signaling.
  findings: []
- id: PMID:26334369
  title: Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.
  findings: []
- id: PMID:26399832
  title: Cell-fate determination by ubiquitin-dependent regulation of translation.
  findings: []
- id: PMID:26906416
  title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
  findings: []
- id: PMID:26949739
  title: Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities
    and Convergent Mechanisms of Action in Autism Spectrum Disorders.
  findings: []
- id: PMID:27152988
  title: The BTB domains of the potassium channel tetramerization domain proteins
    prevalently assume pentameric states.
  findings: []
- id: PMID:27561354
  title: Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune
    DNA-end resection.
  findings: []
- id: PMID:27708159
  title: Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2
    deficiency in mice.
  findings: []
- id: PMID:28169274
  title: Armc5 deletion causes developmental defects and compromises T-cell immune
    responses.
  findings: []
- id: PMID:28395323
  title: 'Defining the human sperm microtubulome: an integrated genomics approach.'
  findings: []
- id: PMID:29249570
  title: Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
  findings: []
- id: PMID:29276004
  title: Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy
    in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
  findings: []
- id: PMID:29769719
  title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis
    and ageing.
  findings: []
- id: PMID:30190310
  title: Dimerization quality control ensures neuronal development and survival.
  findings: []
- id: PMID:31515488
  title: Extensive disruption of protein interactions by genetic variants across the
    allele frequency spectrum in human populations.
  findings: []
- id: PMID:31652307
  title: Kelch-like protein 5-mediated ubiquitination of lysine 183 promotes proteasomal
    degradation of sphingosine kinase 1.
  findings: []
- id: PMID:31898230
  title: 'CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases.'
  findings: []
- id: PMID:32296183
  title: A reference map of the human binary protein interactome.
  findings: []
- id: PMID:32814053
  title: Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins
    and Uncovers Widespread Protein Aggregation in Affected Brains.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human
    interactome.
  findings: []
- id: PMID:34591642
  title: A protein network map of head and neck cancer reveals PIK3CA mutant drug
    sensitivity.
  findings: []
- id: PMID:35512704
  title: Systematic discovery of mutation-directed neo-protein-protein interactions
    in cancer.
  findings: []
- id: PMID:35687106
  title: ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal
    hyperplasia.
  findings: []
- id: PMID:35862218
  title: ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.
  findings: []
- id: PMID:36394357
  title: XAF1 prevents hyperproduction of type I interferon upon viral infection by
    targeting IRF7.
  findings: []
- id: PMID:37207277
  title: Using brain cell-type-specific protein interactomes to interpret neurodevelopmental
    genetic signals in schizophrenia.
  findings: []
- id: PMID:37628845
  title: The Role of PIK3R1 in Metabolic Function and Insulin Sensitivity.
  findings: []
- id: PMID:37788672
  title: Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic
    enzyme.
  findings: []
- id: PMID:38225382
  title: Systematic discovery of protein interaction interfaces using AlphaFold and
    experimental validation.
  findings: []
- id: PMID:38225631
  title: ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation
    increases neural tube defect risks in mice and humans.
  findings: []
- id: PMID:39504960
  title: Redundant pathways for removal of defective RNA polymerase II complexes at
    a promoter-proximal pause checkpoint.
  findings: []
- id: PMID:39667934
  title: CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form parallel mechanisms
    to control early stages of RNA Pol II transcription.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: PMID:8681378
  title: cul-1 is required for cell cycle exit in C. elegans and identifies a novel
    gene family.
  findings: []
- id: PMID:9733711
  title: Cloning and expression analysis of a novel salicylate suppressible gene,
    Hs-CUL-3, a member of cullin/Cdc53 family.
  findings: []
- id: Reactome:R-HSA-1504190
  title: DVL is ubiquitinated by CUL3:KLHL12:RBX1
  findings: []
- id: Reactome:R-HSA-1504193
  title: Ubiquitinated DVL is degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-1504213
  title: DVL is bound by the CUL3:KLHL12:RBX1 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-5635854
  title: GLI2,3 are degraded by the proteasome
  findings: []
- id: Reactome:R-HSA-5635855
  title: phosphorylated GLI proteins bind SPOP:CUL3:RBX1
  findings: []
- id: Reactome:R-HSA-5635856
  title: SPOP:CUL3:RBX1 ubiquitinates GLI2,3
  findings: []
- id: Reactome:R-HSA-5658424
  title: KBTBD7:CUL3:RBX1 ubiquitinates NF1
  findings: []
- id: Reactome:R-HSA-8932327
  title: NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
  findings: []
- id: Reactome:R-HSA-8952630
  title: NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-8952631
  title: AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-8955241
  title: CAND1 binds cytosolic CRL E3 ubiquitin ligases
  findings: []
- id: Reactome:R-HSA-8955289
  title: COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
  findings: []
- id: Reactome:R-HSA-8956040
  title: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
  findings: []
- id: Reactome:R-HSA-9018778
  title: RHOBTB1 binds interacting proteins at the endosome membrane
  findings: []
- id: Reactome:R-HSA-9018787
  title: RHOBTB2 binds interacting proteins at the endosome membrane
  findings: []
- id: Reactome:R-HSA-9706390
  title: RHOBTB3 binds interacting proteins at trans-Golgi network
  findings: []
- id: Reactome:R-HSA-9712274
  title: NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2
  findings: []
- id: Reactome:R-HSA-9755505
  title: KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2
  findings: []
- id: Reactome:R-HSA-9755507
  title: UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex
  findings: []
- id: Reactome:R-HSA-9758090
  title: Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation
  findings: []
- id: Reactome:R-HSA-9759169
  title: p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1
  findings: []
- id: Reactome:R-HSA-9759172
  title: KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer
  findings: []
- id: Reactome:R-HSA-9766645
  title: CUL3:RBX1 ubiquitinates KEAP1
  findings: []
- id: Reactome:R-HSA-9766656
  title: RBX1:CUL3 dissociates from forming autophagosome
  findings: []
- id: Reactome:R-HSA-9766677
  title: MAP1LC3B binds KEAP1 and SQSTM1
  findings: []
- id: Reactome:R-HSA-9766687
  title: SESN1,SESN1 bind SQSTM1 and KEAP1
  findings: []
- id: Reactome:R-HSA-9929484
  title: SPOP:CUL3:RBX1 binds to CD274
  findings: []
- id: Reactome:R-HSA-9929486
  title: SPOP-mediated degradation of CD274 by 26S Proteosome
  findings: []
- id: Reactome:R-HSA-9929490
  title: CD274 ubiquitination by SPOP:CUL3:RBX1 complex
  findings: []