ID DCA10_HUMAN Reviewed; 559 AA. AC Q5QP82; A4VCJ5; Q32NE2; Q8N2Q5; Q96ET5; Q9BTQ5; Q9H5P6; DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot. DT 04-JAN-2005, sequence version 1. DT 28-JAN-2026, entry version 171. DE RecName: Full=DDB1- and CUL4-associated factor 10; DE AltName: Full=WD repeat-containing protein 32; GN Name=DCAF10; Synonyms=WDR32; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 298-559 (ISOFORM 2). RC TISSUE=Ovary, Skin, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 145-559. RC TISSUE=Embryo, and Ileal mucosa; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP FUNCTION, INTERACTION WITH DDB1, AND IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=16949367; DOI=10.1016/j.molcel.2006.08.010; RA Jin J., Arias E.E., Chen J., Harper J.W., Walter J.C.; RT "A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is RT required for S phase destruction of the replication factor Cdt1."; RL Mol. Cell 23:709-721(2006). RN [6] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a RT refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19369195; DOI=10.1074/mcp.m800588-mcp200; RA Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., RA Mann M., Daub H.; RT "Large-scale proteomics analysis of the human kinome."; RL Mol. Cell. Proteomics 8:1751-1764(2009). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-92 AND SER-349, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [10] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-92, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [11] RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-134, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Colon carcinoma; RX PubMed=24129315; DOI=10.1074/mcp.o113.027870; RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M., RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V., RA Bedford M.T., Comb M.J.; RT "Immunoaffinity enrichment and mass spectrometry analysis of protein RT methylation."; RL Mol. Cell. Proteomics 13:372-387(2014). CC -!- FUNCTION: May function as a substrate receptor for CUL4-DDB1 E3 CC ubiquitin-protein ligase complex. {ECO:0000269|PubMed:16949367}. CC -!- PATHWAY: Protein modification; protein ubiquitination. CC -!- SUBUNIT: Interacts with DDB1. {ECO:0000269|PubMed:16949367}. CC -!- INTERACTION: CC Q5QP82; O60884: DNAJA2; NbExp=2; IntAct=EBI-723230, EBI-352957; CC Q5QP82; Q969G2: LHX4; NbExp=3; IntAct=EBI-723230, EBI-2865388; CC Q5QP82; Q9HB07: MYG1; NbExp=3; IntAct=EBI-723230, EBI-709754; CC Q5QP82; Q13356: PPIL2; NbExp=3; IntAct=EBI-723230, EBI-7705988; CC Q5QP82-2; O60260-5: PRKN; NbExp=3; IntAct=EBI-10983996, EBI-21251460; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q5QP82-1; Sequence=Displayed; CC Name=2; CC IsoId=Q5QP82-2; Sequence=VSP_028513; CC -!- SIMILARITY: Belongs to the WD repeat DCAF10 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAI08687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=BAB15574.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC Sequence=BAC11043.1; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL138752; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471071; EAW58263.1; -; Genomic_DNA. DR EMBL; BC003520; AAH03520.2; -; mRNA. DR EMBL; BC011959; AAH11959.2; -; mRNA. DR EMBL; BC108686; AAI08687.1; ALT_INIT; mRNA. DR EMBL; BC139834; AAI39835.1; -; mRNA. DR EMBL; AK026854; BAB15574.1; ALT_INIT; mRNA. DR EMBL; AK074532; BAC11043.1; ALT_INIT; mRNA. DR CCDS; CCDS6613.2; -. [Q5QP82-1] DR RefSeq; NP_001273739.1; NM_001286810.1. DR RefSeq; NP_077321.3; NM_024345.4. [Q5QP82-1] DR RefSeq; XP_005251634.1; XM_005251577.5. [Q5QP82-2] DR RefSeq; XP_054219761.1; XM_054363786.1. [Q5QP82-2] DR AlphaFoldDB; Q5QP82; -. DR SMR; Q5QP82; -. DR BioGRID; 122612; 158. DR ComplexPortal; CPX-2817; CRL4-DCAF10 E3 ubiquitin ligase complex, CUL4A variant. DR ComplexPortal; CPX-2819; CRL4-DCAF10 E3 ubiquitin ligase complex, CUL4B variant. DR FunCoup; Q5QP82; 1237. DR IntAct; Q5QP82; 97. DR MINT; Q5QP82; -. DR STRING; 9606.ENSP00000366953; -. DR GlyGen; Q5QP82; 10 sites, 1 O-linked glycan (9 sites). DR iPTMnet; Q5QP82; -. DR PhosphoSitePlus; Q5QP82; -. DR BioMuta; DCAF10; -. DR DMDM; 74762212; -. DR jPOST; Q5QP82; -. DR MassIVE; Q5QP82; -. DR PaxDb; 9606-ENSP00000366953; -. DR PeptideAtlas; Q5QP82; -. DR ProteomicsDB; 63640; -. [Q5QP82-1] DR ProteomicsDB; 63641; -. [Q5QP82-2] DR Pumba; Q5QP82; -. DR Antibodypedia; 12056; 96 antibodies from 19 providers. DR DNASU; 79269; -. DR Ensembl; ENST00000377724.8; ENSP00000366953.3; ENSG00000122741.17. [Q5QP82-1] DR GeneID; 79269; -. DR KEGG; hsa:79269; -. DR MANE-Select; ENST00000377724.8; ENSP00000366953.3; NM_024345.5; NP_077321.3. DR UCSC; uc004aao.5; human. [Q5QP82-1] DR AGR; HGNC:23686; -. DR ClinPGx; PA165585713; -. DR CTD; 79269; -. DR DisGeNET; 79269; -. DR GeneCards; DCAF10; -. DR HGNC; HGNC:23686; DCAF10. DR HPA; ENSG00000122741; Low tissue specificity. DR MalaCards; DCAF10; -. DR MIM; 620295; gene. DR OpenTargets; ENSG00000122741; -. DR VEuPathDB; HostDB:ENSG00000122741; -. DR eggNOG; KOG0264; Eukaryota. DR eggNOG; KOG4155; Eukaryota. DR GeneTree; ENSGT00390000012666; -. DR InParanoid; Q5QP82; -. DR OMA; STAHEDC; -. DR OrthoDB; 20669at2759; -. DR PAN-GO; Q5QP82; 1 GO annotation based on evolutionary models. DR PhylomeDB; Q5QP82; -. DR PathwayCommons; Q5QP82; -. DR Reactome; R-HSA-8951664; Neddylation. DR SignaLink; Q5QP82; -. DR UniPathway; UPA00143; -. DR Agora; ENSG00000122741; -. DR BioGRID-ORCS; 79269; 14 hits in 1197 CRISPR screens. DR ChiTaRS; DCAF10; human. DR GenomeRNAi; 79269; -. DR Pharos; Q5QP82; Tdark. DR PRO; PR:Q5QP82; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q5QP82; protein. DR Bgee; ENSG00000122741; Expressed in sperm and 189 other cell types or tissues. DR ExpressionAtlas; Q5QP82; baseline and differential. DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; IDA:UniProtKB. DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome. DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. DR FunFam; 2.130.10.10:FF:000116; DDB1- and CUL4-associated factor 10; 1. DR FunFam; 2.130.10.10:FF:000321; DDB1- and CUL4-associated factor 10; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2. DR InterPro; IPR039085; DCA10. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR001680; WD40_rpt. DR PANTHER; PTHR14588; DDB1- AND CUL4-ASSOCIATED FACTOR 10; 1. DR PANTHER; PTHR14588:SF2; DDB1- AND CUL4-ASSOCIATED FACTOR 10; 1. DR Pfam; PF00400; WD40; 3. DR SMART; SM00320; WD40; 5. DR SUPFAM; SSF50978; WD40 repeat-like; 1. DR PROSITE; PS00678; WD_REPEATS_1; 1. DR PROSITE; PS50082; WD_REPEATS_2; 2. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW Alternative splicing; Methylation; Phosphoprotein; KW Proteomics identification; Reference proteome; Repeat; KW Ubl conjugation pathway; WD repeat. FT CHAIN 1..559 FT /note="DDB1- and CUL4-associated factor 10" FT /id="PRO_0000306833" FT REPEAT 166..205 FT /note="WD 1" FT REPEAT 209..247 FT /note="WD 2" FT REPEAT 251..290 FT /note="WD 3" FT REPEAT 296..335 FT /note="WD 4" FT REPEAT 408..448 FT /note="WD 5" FT REPEAT 470..508 FT /note="WD 6" FT REPEAT 526..559 FT /note="WD 7" FT REGION 1..119 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 350..396 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 56..86 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 87..97 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 350..367 FT /note="Low complexity" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 370..381 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 53 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:A2AKB9" FT MOD_RES 63 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT MOD_RES 89 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:A2AKB9" FT MOD_RES 92 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163, FT ECO:0007744|PubMed:24275569" FT MOD_RES 134 FT /note="Omega-N-methylarginine" FT /evidence="ECO:0007744|PubMed:24129315" FT MOD_RES 349 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 352..388 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_028513" FT CONFLICT 309 FT /note="D -> G (in Ref. 4; BAC11043)" FT /evidence="ECO:0000305" FT CONFLICT 332 FT /note="K -> N (in Ref. 3; AAH03520)" FT /evidence="ECO:0000305" FT CONFLICT 457 FT /note="C -> W (in Ref. 4; BAB15574)" FT /evidence="ECO:0000305" SQ SEQUENCE 559 AA; 60582 MW; 583B5A781ADAED38 CRC64; MFPFGPHSPG GDGSAGAGAE EPTPHEGQAA ATGPPSPLHP GADATHPPPP ARSPRRPGAP SLSPAPRSGE LGLPGAPESS TASAPGEPSP PSPPCRRPGP DCRAKSRGRH GLGAGLGGPG ARLFGWLKER SLGRGLFVDP ARDNFRTMTS LYGSIHPADS VYLSTRTHGA VFNLEYSPDG SVLTVACEQT EVLLFDPISS KHIKTLSEAH EDCVNNIRFL DNRLFATCSD DTTIALWDLR KLNTKVCTLH GHTSWVKNIE YDTNTRLLVT SGFDGNVIIW DTNRYTEDGC PHKKFFHTRF LMRMRLTPDC SKMLISTSSG YLLILHDLDL TKSLEVGSYP ILRARRTTSS SDLTTSSSSS GPRVSGSPCH HSDSNSSEKH MSRASQREGV SPRNSLEVVT PEVLGESDHG NCITSLQLHP KGWATLLRCS SNSDDEECTC VYEFQEGAPV RPVSPRCSLR LTHYIEEANV GRGYIKELCF SPDGRMISSP HGYGIRLLGF DKQCSELVDC LPKEASPLRV IRSLYSHNDV VLTTKFSPTH CQIASGCLSG RVSLYQPKF //