DCX

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0001764 neuron migration	IDA PMID:14741102 Doublecortin microtubule affinity is regulated by a balance ...	ACCEPT	Summary: DCX is required for neuronal migration; its leading-process localization and phospho-regulation are linked to migration. Reason: Neuron migration is the defining biological role of DCX: human mutations cause X-linked lissencephaly and subcortical band heterotopia, in utero RNAi in rat blocks radial migration, and DCX is enriched in leading processes of migrating neurons. Supporting Evidence: PMID:14625554 we show that DCX is required for radial migration in developing rat neocortex PMID:14741102 Dcx is highly enriched in the leading processes of migrating neurons and the growth cone region of differentiating neurons file:human/DCX/DCX-uniprot.txt Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development.
GO:0001764 neuron migration	IEA GO_REF:0000002	ACCEPT	Summary: InterPro2GO (DCX chordate family IPR017302) mapping to neuron migration. Reason: Neuron migration is the defining biological role of DCX: human mutations cause X-linked lissencephaly and subcortical band heterotopia, in utero RNAi in rat blocks radial migration, and DCX is enriched in leading processes of migrating neurons. Supporting Evidence: PMID:14625554 we show that DCX is required for radial migration in developing rat neocortex PMID:14741102 Dcx is highly enriched in the leading processes of migrating neurons and the growth cone region of differentiating neurons file:human/DCX/DCX-uniprot.txt Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development.
GO:0005515 protein binding	IPI PMID:21044950 Genome-wide YFP fluorescence complementation screen identifi...	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with TINF2 (Q9BSI4). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:21516116 Next-generation sequencing to generate interactome datasets.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with GOLGA2 (Q08379). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:21516116 Next-generation sequencing to generate interactome datasets.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with IKZF1 (Q13422). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:24607389 Mutations in USP9X are associated with X-linked intellectual...	MODIFY	Summary: Co-immunoprecipitation of DCX with the deubiquitinase USP9X; the paper states DCX is an interacting protein of USP9X, not its substrate. Reason: The cited full-text study supports a more informative MF: binding to the ubiquitin-specific protease USP9X, which colocalizes with DCX in axonal growth cones. Generic protein binding should be replaced by ubiquitin-specific protease binding. This is a peripheral function of DCX. Proposed replacements: ubiquitin-specific protease binding Supporting Evidence: PMID:24607389 DCX coimmunoprecipitated with USP9X and all three variant forms in this assay PMID:24607389 Given the fact that DCX is not a USP9X substrate (rather, it is an interacting protein)
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with ZBTB5 (O15062). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with TRIM27 (P14373). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with TRIM23 (P36406). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with MEOX1 (P50221). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with KRTAP10-8 (P60410). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with GOLGA2 (Q08379). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with CALCOCO2 (Q13137). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with IKZF1 (Q13422). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with KRT40 (Q6A162). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with RINT1 (Q6NUQ1). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with SPAG5 (Q96R06). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with KIFC3 (Q9BVG8). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:25416956 A proteome-scale map of the human interactome network.	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with Q9UJV3-2 (Q9UJV3-2). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari...	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with RINT1 (Q6NUQ1). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling...	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with ZBTB5 (O15062). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005515 protein binding	IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling...	REMOVE	Summary: Proteome-scale or screening-based detection of a DCX interaction with AGMAT (Q9BSE5). Reason: GO:0005515 protein binding carries no functional information and, per project policy, is removed rather than kept; removal does not dispute the reported interaction. The informative molecular activity of DCX is microtubule binding/stabilization, which is annotated separately. This row comes from a large-scale interaction screen (Y2H, BiFC, or AP-MS) and does not indicate a biological activity of DCX; most partners are unrelated to DCX neuronal biology.
GO:0005737 cytoplasm	IEA GO_REF:0000044	ACCEPT	Summary: Cytoplasm (UniProt subcellular location mapping). Reason: DCX is a cytoplasmic microtubule-associated protein; correct general location. Supporting Evidence: PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP.
GO:0005829 cytosol	IDA GO_REF:0000052	ACCEPT	Summary: Cytosol localization (HPA immunofluorescence IDA; Reactome TAS from the neurofascin-binding event). Reason: DCX is a soluble cytoplasmic MAP distributed along microtubules; cytosol is a correct if broad location. Supporting Evidence: PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP.
GO:0005829 cytosol	TAS Reactome:R-NUL-443772	ACCEPT	Summary: Cytosol localization (HPA immunofluorescence IDA; Reactome TAS from the neurofascin-binding event). Reason: DCX is a soluble cytoplasmic MAP distributed along microtubules; cytosol is a correct if broad location. Supporting Evidence: PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP.
GO:0005856 cytoskeleton	TAS PMID:11001923 Interaction between LIS1 and doublecortin, two lissencephaly...	ACCEPT	Summary: Cytoskeleton (TAS, LIS1-DCX interaction study). Reason: DCX associates with tubulin and microtubules; cytoskeleton is a correct general location. Supporting Evidence: PMID:11001923 LIS1 and DCX interact with tubulin and microtubules. PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP.
GO:0005875 microtubule associated complex	TAS PMID:11001923 Interaction between LIS1 and doublecortin, two lissencephaly...	MODIFY	Summary: TAS: part of microtubule associated complex, from the LIS1-DCX interaction study. Reason: DCX is a microtubule lattice-binding MAP rather than a stable subunit of a defined multimeric complex. Its location is better stated as microtubule (located_in), which is directly supported by colocalization and co-sedimentation with microtubules. Proposed replacements: microtubule Supporting Evidence: PMID:11001923 LIS1 and DCX interact with tubulin and microtubules. PMID:15173193 Cotransduction with Dcx-RFP and GFP-tubulin shows Dcx localizes on the MTs. PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP.
GO:0007399 nervous system development	TAS PMID:9489699 A novel CNS gene required for neuronal migration and involve...	KEEP AS NON CORE	Summary: TAS: nervous system development, from the gene discovery paper. Reason: Correct but very broad; DCX's contribution to nervous system development is through neuronal migration, which is annotated directly. Supporting Evidence: PMID:9489699 This novel gene is highly expressed during brain development, mainly in fetal neurons including precursors. PMID:9489699 The complete disorganization observed in lissencephaly and heterotopia thus seems to reflect a failure of early events associated with neuron dispersion.
GO:0007417 central nervous system development	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: Central nervous system development (ARBA IEA; TAS from gene discovery paper). Reason: Correct but broad; DCX's CNS developmental role is cortical neuron migration and lamination, captured by neuron migration. Supporting Evidence: PMID:9489699 The complete disorganization observed in lissencephaly and heterotopia thus seems to reflect a failure of early events associated with neuron dispersion. file:human/DCX/DCX-uniprot.txt Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development.
GO:0007417 central nervous system development	TAS PMID:9489699 A novel CNS gene required for neuronal migration and involve...	KEEP AS NON CORE	Summary: Central nervous system development (ARBA IEA; TAS from gene discovery paper). Reason: Correct but broad; DCX's CNS developmental role is cortical neuron migration and lamination, captured by neuron migration. Supporting Evidence: PMID:9489699 The complete disorganization observed in lissencephaly and heterotopia thus seems to reflect a failure of early events associated with neuron dispersion. file:human/DCX/DCX-uniprot.txt Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development.
GO:0008017 microtubule binding	IDA PMID:14741102 Doublecortin microtubule affinity is regulated by a balance ...	ACCEPT	Summary: DCX binds microtubules; binding is regulated by PKA and MARK phosphorylation. Reason: Microtubule binding is the core molecular function of DCX: it co-assembles with microtubules, binds between protofilaments selectively on 13-protofilament lattices, and patient mutations weaken binding. Supporting Evidence: PMID:14741102 We present evidence that Dcx/microtubule interactions are negatively controlled by Protein Kinase A (PKA) and the MARK/PAR-1 family of protein kinases. PMID:27292316 Functional study showed that the mutant doublecortin protein had a significant reduction of its ability to bind microtubules. PMID:15200960 doublecortin binds between the protofilaments from which microtubules are built, a previously uncharacterized binding site that is ideal for microtubule stabilization
GO:0008017 microtubule binding	IEA GO_REF:0000002	ACCEPT	Summary: InterPro2GO mapping of microtubule binding for the DCX family. Reason: Microtubule binding is the core molecular function of DCX: it co-assembles with microtubules, binds between protofilaments selectively on 13-protofilament lattices, and patient mutations weaken binding. Supporting Evidence: PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP. PMID:15200960 doublecortin binds between the protofilaments from which microtubules are built, a previously uncharacterized binding site that is ideal for microtubule stabilization
GO:0008017 microtubule binding	IMP PMID:27292316 A novel DCX missense mutation in a family with X-linked liss...	ACCEPT	Summary: A patient DCX missense variant (D262G) reduces microtubule binding. Reason: Microtubule binding is the core molecular function of DCX: it co-assembles with microtubules, binds between protofilaments selectively on 13-protofilament lattices, and patient mutations weaken binding. Supporting Evidence: PMID:14741102 We present evidence that Dcx/microtubule interactions are negatively controlled by Protein Kinase A (PKA) and the MARK/PAR-1 family of protein kinases. PMID:27292316 Functional study showed that the mutant doublecortin protein had a significant reduction of its ability to bind microtubules. PMID:15200960 doublecortin binds between the protofilaments from which microtubules are built, a previously uncharacterized binding site that is ideal for microtubule stabilization
GO:0019901 protein kinase binding	IPI PMID:14741102 Doublecortin microtubule affinity is regulated by a balance ...	KEEP AS NON CORE	Summary: IPI with rat MARK2 (O08679): DCX interacts with and is phosphorylated by MARK/PAR-1 kinases. Reason: DCX is a substrate of PKA and MARK kinases that control its microtubule affinity; the curator recorded the interaction with MARK2 from the full text (abstract only available here). The binding reflects substrate recognition rather than a DCX function, so it is kept as non-core. Supporting Evidence: PMID:14741102 We present evidence that Dcx/microtubule interactions are negatively controlled by Protein Kinase A (PKA) and the MARK/PAR-1 family of protein kinases.
GO:0035082 axoneme assembly	IEA GO_REF:0000002	REMOVE	Summary: InterPro2GO mapping (IPR017302) to axoneme assembly. Reason: No evidence links DCX to cilia or axonemes; DCX is a neuronal cytoplasmic MAP expressed in migrating and differentiating neurons. Axonemal/ciliary functions in the doublecortin superfamily belong to other members (e.g. RP1-like photoreceptor ciliary proteins), and this mapping over-propagates to DCX. Supporting Evidence: PMID:10399932 We demonstrate by sedimentation and microscopy studies that Doublecortin is associated with microtubules (MTs) and postulate that it is a novel MAP. file:human/DCX/DCX-uniprot.txt Highly expressed in neuronal cells of fetal brain
GO:0035556 intracellular signal transduction	IEA GO_REF:0000002	REMOVE	Summary: InterPro2GO mapping (doublecortin domain IPR003533/IPR036572) to intracellular signal transduction. Reason: The doublecortin domain is a tubulin/microtubule-binding module that binds between protofilaments, not a signalling domain. UniProt's suggestion of a signalling role is speculative ('may'); there is no evidence DCX transduces an intracellular signal. Supporting Evidence: PMID:15200960 doublecortin binds between the protofilaments from which microtubules are built, a previously uncharacterized binding site that is ideal for microtubule stabilization
GO:0043005 neuron projection	IDA PMID:14741102 Doublecortin microtubule affinity is regulated by a balance ...	ACCEPT	Summary: DCX localizes to neuron projections (leading processes, growth cones, neurite tips). Reason: DCX is enriched in leading processes of migrating neurons and in the distal parts of growing neurites and axons of differentiating neurons. Supporting Evidence: PMID:14741102 Dcx is highly enriched in the leading processes of migrating neurons and the growth cone region of differentiating neurons PMID:10399932 Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neurons, and a strong axonal labeling is observed in differentiating neurons.
GO:0043005 neuron projection	IEA GO_REF:0000120	ACCEPT	Summary: DCX localizes to neuron projections (leading processes, growth cones, neurite tips). Reason: DCX is enriched in leading processes of migrating neurons and in the distal parts of growing neurites and axons of differentiating neurons. Supporting Evidence: PMID:14741102 Dcx is highly enriched in the leading processes of migrating neurons and the growth cone region of differentiating neurons PMID:10399932 Immunohistochemical studies show its localization in the soma and leading processes of tangentially migrating neurons, and a strong axonal labeling is observed in differentiating neurons.
GO:0060041 retina development in camera-type eye	IEA GO_REF:0000002	REMOVE	Summary: InterPro2GO mapping (IPR017302) to retina development in camera-type eye. Reason: There is no evidence for a DCX role in retina development; DCX disease and phenotypes are cortical. This is an over-general family mapping, likely reflecting retinal ciliary functions of other doublecortin-domain proteins. Supporting Evidence: file:human/DCX/DCX-uniprot.txt Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development.
GO:0007026 negative regulation of microtubule depolymerization	IDA PMID:10399933 Doublecortin is a microtubule-associated protein and is expr...	NEW	Summary: DCX stabilizes microtubules against depolymerization by binding between protofilaments. Reason: DCX-decorated microtubules resist depolymerization, and structural work shows DCX binds the inter-protofilament groove, a site ideal for stabilization. DCX itself performs the stabilizing work (lattice binding), so it participates in the process. This is the process-level description of DCX's core activity and is how other stabilizing MAPs are annotated. Supporting Evidence: PMID:10399933 overexpression of DCX in heterologous cells leads to a dramatic microtubule phenotype that is resistant to depolymerization PMID:15200960 doublecortin binds between the protofilaments from which microtubules are built, a previously uncharacterized binding site that is ideal for microtubule stabilization PMID:15200960 Doublecortin stabilizes microtubules and stimulates their polymerization but has no homology with other MAPs. file:human/DCX/DCX-deep-research-falcon.md Early biochemical work showed that DCX colocalizes and coassembles with microtubules, promotes polymerization and bundling, and renders a fraction of microtubules resistant to colchicine and cold-induced depolymerization.

Gene Description

Existing Annotations Review

Core Functions

Binds and stabilizes the microtubule lattice (between protofilaments, 13-pf selective) in migrating neurons, maintaining the microtubule arrays of the leading process and perinuclear cage needed for neuronal migration.

References

Suggested Questions for Experts

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Falcon

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