ID   DJC14_HUMAN             Reviewed;         702 AA.
AC   Q6Y2X3; A5YM67; Q17RY2; Q66K17; Q96N59; Q96T63;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   28-JAN-2026, entry version 166.
DE   RecName: Full=DnaJ homolog subfamily C member 14;
DE   AltName: Full=DnaJ protein homolog 3;
DE   AltName: Full=Dopamine receptor-interacting protein of 78 kDa;
DE            Short=DRIP78;
DE   AltName: Full=Human DnaJ protein 3;
DE            Short=hDj-3;
GN   Name=DNAJC14; Synonyms=DRIP78, HDJ3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Fetal brain;
RX   PubMed=12768437; DOI=10.1007/s10038-003-0012-8;
RA   Chen J., Huang Y., Wu H., Ni X., Cheng H., Fan J., Gu S., Gu X., Cao G.,
RA   Ying K., Mao Y., Lu Y., Xie Y.;
RT   "Molecular cloning and characterization of a novel human J-domain protein
RT   gene (HDJ3) from the fetal brain.";
RL   J. Hum. Genet. 48:217-221(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 254-702.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 490-702.
RX   PubMed=11331877; DOI=10.1038/35074561;
RA   Bermak J.C., Li M., Bullock C.M., Zhou Q.-Y.;
RT   "Regulation of transport of the dopamine D1 receptor by a new membrane-
RT   associated ER protein.";
RL   Nat. Cell Biol. 3:492-498(2001).
CC   -!- FUNCTION: Regulates the export of target proteins, such as DRD1, from
CC       the endoplasmic reticulum to the cell surface. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal
CC       domain. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q6Y2X3; P82979: SARNP; NbExp=3; IntAct=EBI-10038974, EBI-347495;
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in pancreas and selectively
CC       expressed in brain, lung, liver, skeletal muscle and kidney.
CC       {ECO:0000269|PubMed:12768437}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB71050.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY188447; AAO73451.1; -; mRNA.
DR   EMBL; EF560741; ABQ59051.1; -; mRNA.
DR   EMBL; CH471054; EAW96833.1; -; Genomic_DNA.
DR   EMBL; BC080655; AAH80655.1; -; mRNA.
DR   EMBL; BC117146; AAI17147.1; -; mRNA.
DR   EMBL; BC117148; AAI17149.1; -; mRNA.
DR   EMBL; AK055945; BAB71050.1; ALT_INIT; mRNA.
DR   EMBL; AF351784; AAK56241.1; -; mRNA.
DR   CCDS; CCDS8894.1; -.
DR   RefSeq; NP_001381616.1; NM_001394687.1.
DR   RefSeq; NP_001381617.1; NM_001394688.1.
DR   RefSeq; NP_001381618.1; NM_001394689.1.
DR   RefSeq; NP_115740.5; NM_032364.5.
DR   AlphaFoldDB; Q6Y2X3; -.
DR   SMR; Q6Y2X3; -.
DR   BioGRID; 124515; 53.
DR   CORUM; Q6Y2X3; -.
DR   FunCoup; Q6Y2X3; 700.
DR   IntAct; Q6Y2X3; 13.
DR   MINT; Q6Y2X3; -.
DR   STRING; 9606.ENSP00000350223; -.
DR   GlyCosmos; Q6Y2X3; 1 site, 1 glycan.
DR   GlyGen; Q6Y2X3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q6Y2X3; -.
DR   PhosphoSitePlus; Q6Y2X3; -.
DR   BioMuta; DNAJC14; -.
DR   DMDM; 110808200; -.
DR   jPOST; Q6Y2X3; -.
DR   MassIVE; Q6Y2X3; -.
DR   PaxDb; 9606-ENSP00000350223; -.
DR   PeptideAtlas; Q6Y2X3; -.
DR   ProteomicsDB; 67835; -.
DR   Pumba; Q6Y2X3; -.
DR   Antibodypedia; 3011; 61 antibodies from 14 providers.
DR   DNASU; 85406; -.
DR   Ensembl; ENST00000317287.5; ENSP00000317500.5; ENSG00000135392.20.
DR   Ensembl; ENST00000357606.7; ENSP00000350223.3; ENSG00000135392.20.
DR   Ensembl; ENST00000546957.2; ENSP00000448876.2; ENSG00000135392.20.
DR   Ensembl; ENST00000547445.2; ENSP00000450196.2; ENSG00000135392.20.
DR   Ensembl; ENST00000678005.2; ENSP00000504134.1; ENSG00000135392.20.
DR   GeneID; 85406; -.
DR   KEGG; hsa:85406; -.
DR   MANE-Select; ENST00000678005.2; ENSP00000504134.1; NM_032364.6; NP_115740.5.
DR   UCSC; uc001shx.1; human.
DR   AGR; HGNC:24581; -.
DR   ClinPGx; PA134940402; -.
DR   CTD; 85406; -.
DR   DisGeNET; 85406; -.
DR   GeneCards; DNAJC14; -.
DR   HGNC; HGNC:24581; DNAJC14.
DR   HPA; ENSG00000135392; Low tissue specificity.
DR   MIM; 606092; gene.
DR   OpenTargets; ENSG00000135392; -.
DR   VEuPathDB; HostDB:ENSG00000135392; -.
DR   eggNOG; KOG0720; Eukaryota.
DR   GeneTree; ENSGT00940000155637; -.
DR   HOGENOM; CLU_020746_0_0_1; -.
DR   InParanoid; Q6Y2X3; -.
DR   OMA; WLELPWF; -.
DR   OrthoDB; 1507364at2759; -.
DR   PAN-GO; Q6Y2X3; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; Q6Y2X3; -.
DR   PathwayCommons; Q6Y2X3; -.
DR   SignaLink; Q6Y2X3; -.
DR   SIGNOR; Q6Y2X3; -.
DR   Agora; ENSG00000135392; -.
DR   BioGRID-ORCS; 85406; 13 hits in 1155 CRISPR screens.
DR   ChiTaRS; DNAJC14; human.
DR   GeneWiki; DNAJC14; -.
DR   GenomeRNAi; 85406; -.
DR   Pharos; Q6Y2X3; Tbio.
DR   PRO; PR:Q6Y2X3; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q6Y2X3; protein.
DR   Bgee; ENSG00000135392; Expressed in islet of Langerhans and 147 other cell types or tissues.
DR   ExpressionAtlas; Q6Y2X3; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0050780; F:dopamine receptor binding; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd06257; DnaJ; 1.
DR   FunFam; 1.10.287.110:FF:000057; dnaJ homolog subfamily C member 14; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   InterPro; IPR032843; Jiv.
DR   InterPro; IPR052317; Viral_replicn-host_int_reg.
DR   PANTHER; PTHR44665; DNAJ HOMOLOG SUBFAMILY C MEMBER 14; 1.
DR   PANTHER; PTHR44665:SF1; DNAJ HOMOLOG SUBFAMILY C MEMBER 14; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   Pfam; PF14901; Jiv90; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Endoplasmic reticulum; Membrane; Protein transport;
KW   Proteomics identification; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..702
FT                   /note="DnaJ homolog subfamily C member 14"
FT                   /id="PRO_0000247493"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          443..507
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          1..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          658..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        75..84
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..103
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        165..175
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..201
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..227
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        659..676
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        690..702
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        285
FT                   /note="D -> N (in Ref. 1; AAO73451)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        460
FT                   /note="K -> R (in Ref. 1; AAO73451)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   702 AA;  78569 MW;  DAECF48B7196C7F2 CRC64;
     MAQKHPGERG LYGAHHSGGA SLRTLGPSVD PEIPSFSGLR DSAGTAPNGT RCLTEHSGPK
     HTQHPNPAHW LDPSHGPPGG PGPPRDAEDP DQSETSSEEE SGVDQELSKE NETGNQKDGN
     SFLSIPSACN CQGTPGIPEG PYSEGGNGSS SNFCHHCTSP ALGEDELEEE YDDEESLKFP
     SDFSRVSSGK KPPSRRQRHR FPTKEDTREG GRRDPRSPGR HRLGRKRSQA DKRKGLGLWG
     AEELCQLGQA GFWWLIELLV LVGEYVETCG HLIYACRQLK SSDLDLFRVW MGVWTGRLGG
     WAQVMFQFLS QGFYCGVGLF TRFLKLLGAL LLLALALFLG FLQLGWRFLV GLGDRLGWRD
     KATWLFSWLD SPALQRCLTL LRDSRPWQRL VRIVQWGWLE LPWVKQNINR QGNAPVASGR
     YCQPEEEVAR LLTMAGVPED ELNPFHVLGV EATASDVELK KAYRQLAVMV HPDKNHHPRA
     EEAFKVLRAA WDIVSNAEKR KEYEMKRMAE NELSRSVNEF LSKLQDDLKE AMNTMMCSRC
     QGKHRRFEMD REPKSARYCA ECNRLHPAEE GDFWAESSML GLKITYFALM DGKVYDITEW
     AGCQRVGISP DTHRVPYHIS FGSRIPGTRG RQRATPDAPP ADLQDFLSRI FQVPPGQMPN
     GNFFAAPQPA PGAAAASKPN STVPKGEAKP KRRKKVRRPF QR
//