ID DJC25_HUMAN Reviewed; 360 AA. AC Q9H1X3; Q5QTD8; Q96BN9; DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 28-JAN-2026, entry version 164. DE RecName: Full=DnaJ homolog subfamily C member 25; GN Name=DNAJC25; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Prostate; RA Zan Q., Guo J.H., Yu L.; RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). RC TISSUE=Kidney; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9H1X3-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9H1X3-2; Sequence=VSP_035180; CC Name=3; CC IsoId=Q9H1X3-3; Sequence=VSP_035181, VSP_035182; CC -!- SIMILARITY: Belongs to the DNAJC25 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF447177; AAQ04643.1; -; mRNA. DR EMBL; AK095452; BAG53057.1; -; mRNA. DR EMBL; BT007068; AAP35731.1; -; mRNA. DR EMBL; AL135787; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471105; EAW59082.1; -; Genomic_DNA. DR EMBL; CH471105; EAW59085.1; -; Genomic_DNA. DR EMBL; BC015391; AAH15391.1; -; mRNA. DR EMBL; BC048318; AAH48318.1; -; mRNA. DR CCDS; CCDS43862.1; -. [Q9H1X3-1] DR RefSeq; NP_001015882.2; NM_001015882.3. [Q9H1X3-1] DR RefSeq; NP_004116.2; NM_004125.3. [Q9H1X3-3] DR AlphaFoldDB; Q9H1X3; -. DR SMR; Q9H1X3; -. DR BioGRID; 139240; 288. DR BioGRID; 139267; 36. DR FunCoup; Q9H1X3; 791. DR IntAct; Q9H1X3; 72. DR STRING; 9606.ENSP00000320650; -. DR iPTMnet; Q9H1X3; -. DR PhosphoSitePlus; Q9H1X3; -. DR SwissPalm; Q9H1X3; -. DR BioMuta; DNAJC25; -. DR DMDM; 74752592; -. DR jPOST; Q9H1X3; -. DR MassIVE; Q9H1X3; -. DR PaxDb; 9606-ENSP00000320650; -. DR PeptideAtlas; Q9H1X3; -. DR ProteomicsDB; 80452; -. [Q9H1X3-1] DR ProteomicsDB; 80453; -. [Q9H1X3-2] DR ProteomicsDB; 80454; -. [Q9H1X3-3] DR Pumba; Q9H1X3; -. DR Antibodypedia; 15144; 94 antibodies from 17 providers. DR DNASU; 548645; -. DR Ensembl; ENST00000313525.4; ENSP00000320650.3; ENSG00000059769.21. [Q9H1X3-1] DR GeneID; 548645; -. DR KEGG; hsa:548645; -. DR KEGG; hsa:552891; -. DR MANE-Select; ENST00000313525.4; ENSP00000320650.3; NM_001015882.3; NP_001015882.2. DR UCSC; uc004bfl.3; human. [Q9H1X3-1] DR AGR; HGNC:34187; -. DR AGR; HGNC:37501; -. DR ClinPGx; PA165585764; -. DR CTD; 548645; -. DR DisGeNET; 548645; -. DR GeneCards; DNAJC25; -. DR HGNC; HGNC:34187; DNAJC25. DR HPA; ENSG00000059769; Tissue enriched (liver). DR OpenTargets; ENSG00000059769; -. DR VEuPathDB; HostDB:ENSG00000059769; -. DR eggNOG; KOG0722; Eukaryota. DR GeneTree; ENSGT00390000013355; -. DR HOGENOM; CLU_055735_0_0_1; -. DR InParanoid; Q9H1X3; -. DR OMA; WFWRYTV; -. DR OrthoDB; 270167at2759; -. DR PAN-GO; Q9H1X3; 2 GO annotations based on evolutionary models. DR PhylomeDB; Q9H1X3; -. DR PathwayCommons; Q9H1X3; -. DR SignaLink; Q9H1X3; -. DR Agora; ENSG00000059769; -. DR BioGRID-ORCS; 548645; 10 hits in 1133 CRISPR screens. DR BioGRID-ORCS; 552891; 2 hits in 163 CRISPR screens. DR ChiTaRS; DNAJC25; human. DR Pharos; Q9H1X3; Tdark. DR PRO; PR:Q9H1X3; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; Q9H1X3; protein. DR Bgee; ENSG00000059769; Expressed in epithelial cell of pancreas and 178 other cell types or tissues. DR ExpressionAtlas; Q9H1X3; baseline and differential. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central. DR GO; GO:0006457; P:protein folding; IBA:GO_Central. DR CDD; cd06257; DnaJ; 1. DR FunFam; 1.10.287.110:FF:000036; dnaJ homolog subfamily C member 25; 1. DR Gene3D; 1.10.287.110; DnaJ domain; 1. DR InterPro; IPR001623; DnaJ_domain. DR InterPro; IPR044632; DNAJC25-like. DR InterPro; IPR036869; J_dom_sf. DR PANTHER; PTHR44176; DNAJ HOMOLOG SUBFAMILY C MEMBER 25; 1. DR PANTHER; PTHR44176:SF1; DNAJ HOMOLOG SUBFAMILY C MEMBER 25; 1. DR Pfam; PF00226; DnaJ; 1. DR PRINTS; PR00625; JDOMAIN. DR SMART; SM00271; DnaJ; 1. DR SUPFAM; SSF46565; Chaperone J-domain; 1. DR PROSITE; PS50076; DNAJ_2; 1. PE 1: Evidence at protein level; KW Alternative splicing; Chaperone; Membrane; Proteomics identification; KW Reference proteome; Transmembrane; Transmembrane helix. FT CHAIN 1..360 FT /note="DnaJ homolog subfamily C member 25" FT /id="PRO_0000348569" FT TRANSMEM 20..40 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 150..170 FT /note="Helical" FT /evidence="ECO:0000255" FT TRANSMEM 244..264 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 49..124 FT /note="J" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00286" FT VAR_SEQ 1..122 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1" FT /id="VSP_035180" FT VAR_SEQ 113..153 FT /note="DEETRKDYDYMLDHPEEYYSHYYHYYSRRLAPKVDVRVVIL -> VSQAAAE FT LQQYCMQNACKDALLVGVPAGSNPFREPRSCALL (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3" FT /id="VSP_035181" FT VAR_SEQ 154..360 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3" FT /id="VSP_035182" SQ SEQUENCE 360 AA; 42404 MW; 6D6673C4B71ABD19 CRC64; MGAPLLSPGW GAGAAGRRWW MLLAPLLPAL LLVRPAGALV EGLYCGTRDC YEVLGVSRSA GKAEIARAYR QLARRYHPDR YRPQPGDEGP GRTPQSAEEA FLLVATAYET LKDEETRKDY DYMLDHPEEY YSHYYHYYSR RLAPKVDVRV VILVSVCAIS VFQFFSWWNS YNKAISYLAT VPKYRIQATE IAKQQGLLKK AKEKGKNKKS KEEIRDEEEN IIKNIIKSKI DIKGGYQKPQ ICDLLLFQII LAPFHLCSYI VWYCRWIYNF NIKGKEYGEE ERLYIIRKSM KMSKSQFDSL EDHQKETFLK RELWIKENYE VYKQEQEEEL KKKLANDPRW KRYRRWMKNE GPGRLTFVDD //