ID   DNJC4_HUMAN             Reviewed;         241 AA.
AC   Q9NNZ3; O14716;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   28-JAN-2026, entry version 173.
DE   RecName: Full=DnaJ homolog subfamily C member 4;
DE   AltName: Full=DnaJ-like protein HSPF2;
DE   AltName: Full=Multiple endocrine neoplasia type 1 candidate protein number 18;
GN   Name=DNAJC4; Synonyms=HSPF2, MCG18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9473517; DOI=10.1006/bbrc.1997.8091;
RA   Silins G., Grimmond S., Hayward N.;
RT   "Characterisation of a new human and murine member of the DnaJ family of
RT   proteins.";
RL   Biochem. Biophys. Res. Commun. 243:273-276(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RA   Lloyd S.E., Thakker R.V.;
RT   "Identification and characterisation of a novel human Dnaj gene, HSPF2,
RT   mapping to chromosome 11q13.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- INTERACTION:
CC       Q9NNZ3; P42858: HTT; NbExp=12; IntAct=EBI-4397791, EBI-466029;
CC       Q9NNZ3; O76024: WFS1; NbExp=3; IntAct=EBI-4397791, EBI-720609;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB82426.1; Type=Miscellaneous discrepancy; Note=Several sequence rearrangements.; Evidence={ECO:0000305};
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DR   EMBL; AF036874; AAF97845.1; -; mRNA.
DR   EMBL; BC044584; AAH44584.1; -; mRNA.
DR   EMBL; BC057849; AAH57849.1; -; mRNA.
DR   EMBL; AF012106; AAB82426.1; ALT_SEQ; mRNA.
DR   CCDS; CCDS41666.1; -.
DR   PIR; JE0169; JE0169.
DR   RefSeq; NP_001294909.1; NM_001307980.1.
DR   RefSeq; NP_001294910.1; NM_001307981.1.
DR   RefSeq; NP_005519.2; NM_005528.4.
DR   RefSeq; XP_054224592.1; XM_054368617.1.
DR   AlphaFoldDB; Q9NNZ3; -.
DR   SMR; Q9NNZ3; -.
DR   BioGRID; 109570; 56.
DR   FunCoup; Q9NNZ3; 130.
DR   IntAct; Q9NNZ3; 4.
DR   STRING; 9606.ENSP00000320548; -.
DR   iPTMnet; Q9NNZ3; -.
DR   PhosphoSitePlus; Q9NNZ3; -.
DR   BioMuta; DNAJC4; -.
DR   DMDM; 18203312; -.
DR   jPOST; Q9NNZ3; -.
DR   MassIVE; Q9NNZ3; -.
DR   PaxDb; 9606-ENSP00000396896; -.
DR   PeptideAtlas; Q9NNZ3; -.
DR   ProteomicsDB; 81878; -.
DR   Antibodypedia; 2326; 60 antibodies from 14 providers.
DR   DNASU; 3338; -.
DR   Ensembl; ENST00000321685.7; ENSP00000396896.2; ENSG00000110011.15.
DR   Ensembl; ENST00000628077.3; ENSP00000486499.2; ENSG00000110011.15.
DR   GeneID; 3338; -.
DR   KEGG; hsa:3338; -.
DR   MANE-Select; ENST00000628077.3; ENSP00000486499.2; NM_005528.4; NP_005519.2.
DR   UCSC; uc001nys.4; human.
DR   AGR; HGNC:5271; -.
DR   ClinPGx; PA27421; -.
DR   CTD; 3338; -.
DR   DisGeNET; 3338; -.
DR   GeneCards; DNAJC4; -.
DR   HGNC; HGNC:5271; DNAJC4.
DR   HPA; ENSG00000110011; Tissue enhanced (testis).
DR   MIM; 604189; gene.
DR   OpenTargets; ENSG00000110011; -.
DR   VEuPathDB; HostDB:ENSG00000110011; -.
DR   eggNOG; KOG0691; Eukaryota.
DR   GeneTree; ENSGT00510000048574; -.
DR   HOGENOM; CLU_081597_0_0_1; -.
DR   InParanoid; Q9NNZ3; -.
DR   OMA; LCRLWPY; -.
DR   OrthoDB; 552049at2759; -.
DR   PAN-GO; Q9NNZ3; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; Q9NNZ3; -.
DR   PathwayCommons; Q9NNZ3; -.
DR   SignaLink; Q9NNZ3; -.
DR   Agora; ENSG00000110011; -.
DR   BioGRID-ORCS; 3338; 10 hits in 1166 CRISPR screens.
DR   ChiTaRS; DNAJC4; human.
DR   GenomeRNAi; 3338; -.
DR   Pharos; Q9NNZ3; Tdark.
DR   PRO; PR:Q9NNZ3; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9NNZ3; protein.
DR   Bgee; ENSG00000110011; Expressed in right testis and 160 other cell types or tissues.
DR   ExpressionAtlas; Q9NNZ3; baseline and differential.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
DR   GO; GO:0006457; P:protein folding; NAS:UniProtKB.
DR   GO; GO:0006986; P:response to unfolded protein; TAS:ProtInc.
DR   CDD; cd06257; DnaJ; 1.
DR   FunFam; 1.10.287.110:FF:000087; DnaJ homolog subfamily C member 4; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   InterPro; IPR052763; DnaJ_C4.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR036869; J_dom_sf.
DR   PANTHER; PTHR44825; -; 1.
DR   PANTHER; PTHR44825:SF1; DNAJ HOMOLOG SUBFAMILY C MEMBER 4; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Membrane; Proteomics identification; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..241
FT                   /note="DnaJ homolog subfamily C member 4"
FT                   /id="PRO_0000071049"
FT   TRANSMEM        156..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..99
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          88..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..99
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   241 AA;  27593 MW;  EA186D2FA6C2E179 CRC64;
     MPPLLPLRLC RLWPRNPPSR LLGAAAGQRS RPSTYYELLG VHPGASTEEV KRAFFSKSKE
     LHPDRDPGNP SLHSRFVELS EAYRVLSREQ SRRSYDDQLR SGSPPKSPRT TVHDKSAHQT
     HSSWTPPNAQ YWSQFHSVRP QGPQLRQQQH KQNKQVLGYC LLLMLAGMGL HYIAFRKVKQ
     MHLNFMDEKD RIITAFYNEA RARARANRGI LQQERQRLGQ RQPPPSEPTQ GPEIVPRGAG
     P
//