# DNAJC5G (Q8N7S2) research notes

## Identity
- DnaJ homolog subfamily C member 5G; cysteine string protein-gamma (CSP-gamma). Paralog of DNAJC5/CSPalpha and DNAJC5B/CSP-beta.
- 189 aa. J domain (aa 17-98) [file:human/DNAJC5G/DNAJC5G-uniprot.txt "DOMAIN 17..98 /note=\"J\""]. Cysteine-string region. Palmitoylation By similarity.
- Testis specific [uniprot "TISSUE SPECIFICITY: Testis specific"]. Pharos Tdark (very poorly characterized). PAN-GO: 0 GO annotations from evolutionary models.

## Function status
- No experimental functional characterization. By family it is an HSP70/HSC70 J-domain co-chaperone (DnaJ/HSP40), membrane lipid-anchored (palmitoylated, By similarity). Evidence level PE2 (transcript only).
- SUBCELLULAR LOCATION: Membrane; Lipid-anchor (By similarity / ECO:0000250).

## Curation judgment
- Core MF: predicted HSP70 co-chaperone (unfolded protein binding / Hsp70 protein binding) via J domain, but NOT experimentally verified -> assign family-level MF cautiously (unfolded protein binding).
- cytoplasm (IEA ARBA) and membrane (IEA SubCell) localizations: ACCEPT/KEEP_AS_NON_CORE; membrane is the lipid-anchor compartment.