ID   DNJ5G_HUMAN             Reviewed;         189 AA.
AC   Q8N7S2; B4DY29; Q53SY5; Q8IYQ4; Q96RJ8;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   28-JAN-2026, entry version 156.
DE   RecName: Full=DnaJ homolog subfamily C member 5G;
DE   AltName: Full=Cysteine string protein-gamma;
DE            Short=CSP-gamma;
GN   Name=DNAJC5G;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 57-165 (ISOFORM 1).
RA   Tobaben S., Stahl B.;
RT   "Novel isoforms of the cysteine string protein.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8N7S2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8N7S2-2; Sequence=VSP_056967, VSP_056968;
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- PTM: Palmitoylated. {ECO:0000250}.
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DR   EMBL; AK097736; BAC05155.1; -; mRNA.
DR   EMBL; AK302239; BAG63591.1; -; mRNA.
DR   EMBL; AC013413; AAY24295.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00608.1; -; Genomic_DNA.
DR   EMBL; CH471053; EAX00609.1; -; Genomic_DNA.
DR   EMBL; BC035194; AAH35194.2; -; mRNA.
DR   EMBL; AF368277; AAK60572.1; -; mRNA.
DR   CCDS; CCDS1744.1; -. [Q8N7S2-1]
DR   CCDS; CCDS77397.1; -. [Q8N7S2-2]
DR   RefSeq; NP_001290056.1; NM_001303127.2. [Q8N7S2-1]
DR   RefSeq; NP_001290057.1; NM_001303128.2. [Q8N7S2-2]
DR   RefSeq; NP_775921.1; NM_173650.3. [Q8N7S2-1]
DR   RefSeq; XP_006712058.1; XM_006711995.4. [Q8N7S2-1]
DR   RefSeq; XP_016859361.1; XM_017003872.3. [Q8N7S2-1]
DR   RefSeq; XP_016859362.1; XM_017003873.3. [Q8N7S2-1]
DR   RefSeq; XP_016859363.1; XM_017003874.3. [Q8N7S2-1]
DR   RefSeq; XP_054197477.1; XM_054341502.1. [Q8N7S2-1]
DR   RefSeq; XP_054197478.1; XM_054341503.1. [Q8N7S2-1]
DR   RefSeq; XP_054197479.1; XM_054341504.1. [Q8N7S2-1]
DR   RefSeq; XP_054197480.1; XM_054341505.1. [Q8N7S2-1]
DR   RefSeq; XP_054197481.1; XM_054341506.1. [Q8N7S2-1]
DR   RefSeq; XP_054197482.1; XM_054341507.1. [Q8N7S2-2]
DR   AlphaFoldDB; Q8N7S2; -.
DR   SMR; Q8N7S2; -.
DR   BioGRID; 130021; 9.
DR   FunCoup; Q8N7S2; 168.
DR   STRING; 9606.ENSP00000296097; -.
DR   iPTMnet; Q8N7S2; -.
DR   PhosphoSitePlus; Q8N7S2; -.
DR   BioMuta; DNAJC5G; -.
DR   DMDM; 50400554; -.
DR   MassIVE; Q8N7S2; -.
DR   PaxDb; 9606-ENSP00000296097; -.
DR   ProteomicsDB; 5491; -.
DR   Antibodypedia; 28353; 120 antibodies from 23 providers.
DR   DNASU; 285126; -.
DR   Ensembl; ENST00000296097.8; ENSP00000296097.3; ENSG00000163793.13. [Q8N7S2-1]
DR   Ensembl; ENST00000402462.5; ENSP00000384305.1; ENSG00000163793.13. [Q8N7S2-1]
DR   Ensembl; ENST00000406962.1; ENSP00000385533.1; ENSG00000163793.13. [Q8N7S2-2]
DR   GeneID; 285126; -.
DR   KEGG; hsa:285126; -.
DR   MANE-Select; ENST00000296097.8; ENSP00000296097.3; NM_173650.3; NP_775921.1.
DR   UCSC; uc002rjl.2; human. [Q8N7S2-1]
DR   AGR; HGNC:24844; -.
DR   ClinPGx; PA134880296; -.
DR   CTD; 285126; -.
DR   GeneCards; DNAJC5G; -.
DR   HGNC; HGNC:24844; DNAJC5G.
DR   HPA; ENSG00000163793; Group enriched (epididymis, testis).
DR   MIM; 613946; gene.
DR   OpenTargets; ENSG00000163793; -.
DR   VEuPathDB; HostDB:ENSG00000163793; -.
DR   eggNOG; KOG0716; Eukaryota.
DR   GeneTree; ENSGT00940000162434; -.
DR   HOGENOM; CLU_2249162_0_0_1; -.
DR   InParanoid; Q8N7S2; -.
DR   OMA; FIMNSCW; -.
DR   OrthoDB; 445556at2759; -.
DR   PAN-GO; Q8N7S2; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; Q8N7S2; -.
DR   PathwayCommons; Q8N7S2; -.
DR   Agora; ENSG00000163793; -.
DR   BioGRID-ORCS; 285126; 15 hits in 1147 CRISPR screens.
DR   GenomeRNAi; 285126; -.
DR   Pharos; Q8N7S2; Tdark.
DR   PRO; PR:Q8N7S2; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8N7S2; protein.
DR   Bgee; ENSG00000163793; Expressed in left testis and 78 other cell types or tissues.
DR   ExpressionAtlas; Q8N7S2; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-ARBA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd06257; DnaJ; 1.
DR   Gene3D; 1.10.287.110; DnaJ domain; 1.
DR   InterPro; IPR051434; DnaJ_C_subfamily_member5.
DR   InterPro; IPR001623; DnaJ_domain.
DR   InterPro; IPR018253; DnaJ_domain_CS.
DR   InterPro; IPR036869; J_dom_sf.
DR   PANTHER; PTHR44027; DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG; 1.
DR   PANTHER; PTHR44027:SF2; DNAJ HOMOLOG SUBFAMILY C MEMBER 5G; 1.
DR   Pfam; PF00226; DnaJ; 1.
DR   PRINTS; PR00625; JDOMAIN.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; Chaperone J-domain; 2.
DR   PROSITE; PS00636; DNAJ_1; 1.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chaperone; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome.
FT   CHAIN           1..189
FT                   /note="DnaJ homolog subfamily C member 5G"
FT                   /id="PRO_0000071057"
FT   DOMAIN          17..98
FT                   /note="J"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00286"
FT   REGION          154..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..171
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         38..104
FT                   /note="SHSALLPHPPFEYHLGRKLALRYHPDKNPGNAQAAEIFKEINAAHAILSDSK
FT                   KRKIYDQHGSLGIYL -> RHLSSCVLCSLVAVSVVAAVFAVEHLNHHLSRIVGENISR
FT                   MSRVSLQGQEPNVILEARKIAKMIFKR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056967"
FT   VAR_SEQ         105..189
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056968"
FT   VARIANT         4
FT                   /note="V -> G (in dbSNP:rs17005979)"
FT                   /id="VAR_033882"
FT   VARIANT         51
FT                   /note="H -> R (in dbSNP:rs13414011)"
FT                   /id="VAR_033883"
SQ   SEQUENCE   189 AA;  21433 MW;  EF8FCAE0F1A841A1 CRC64;
     MSTVKEAAHR LSKSEMSLYA VLDLKKGASP EDFKKSYSHS ALLPHPPFEY HLGRKLALRY
     HPDKNPGNAQ AAEIFKEINA AHAILSDSKK RKIYDQHGSL GIYLYDHFGE EGVRYYFILN
     SCWFKTLVIL CTLLTCCCFC CCCCFCCGAL KPPPEQDSGR KYQQNVQSQP PRSGAKCDFR
     SEENSEDDF
//