GENE PRODUCT DB	GENE PRODUCT ID	SYMBOL	QUALIFIER	GO TERM	GO NAME	GO ASPECT	ECO ID	GO EVIDENCE CODE	REFERENCE	WITH/FROM	TAXON ID	TAXON NAME	ASSIGNED BY	GENE NAME	DATE
UniProtKB	Q92611	EDEM1	enables	GO:0005509	calcium ion binding	molecular_function	ECO:0000256	IEA	GO_REF:0000002	InterPro:IPR001382|InterPro:IPR036026	9606	Homo sapiens	InterPro	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	located_in	GO:0005783	endoplasmic reticulum	cellular_component	ECO:0000256	IEA	GO_REF:0000117	ARBA:ARBA00028672	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	located_in	GO:0005789	endoplasmic reticulum membrane	cellular_component	ECO:0000501	IEA	GO_REF:0000120	UniProtKB:Q925U4|ensembl:ENSMUSP00000086565|UniProtKB-SubCell:SL-0097	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	involved_in	GO:0005975	carbohydrate metabolic process	biological_process	ECO:0000256	IEA	GO_REF:0000002	InterPro:IPR012341	9606	Homo sapiens	InterPro	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	located_in	GO:0016020	membrane	cellular_component	ECO:0000256	IEA	GO_REF:0000002	InterPro:IPR001382|InterPro:IPR036026	9606	Homo sapiens	InterPro	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	involved_in	GO:0036503	ERAD pathway	biological_process	ECO:0000256	IEA	GO_REF:0000117	ARBA:ARBA00029018	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	involved_in	GO:1904380	endoplasmic reticulum mannose trimming	biological_process	ECO:0000501	IEA	GO_REF:0000120	ARBA:ARBA00089809|UniProtKB:Q925U4|ensembl:ENSMUSP00000086565|InterPro:IPR044674	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20260601
UniProtKB	Q92611	EDEM1	involved_in	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	biological_process	ECO:0000501	IEA	GO_REF:0000120	ARBA:ARBA00087563|UniProtKB:Q925U4|ensembl:ENSMUSP00000086565	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20260529
UniProtKB	Q92611	EDEM1	enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	molecular_function	ECO:0000304	TAS	Reactome:R-HSA-6782685		9606	Homo sapiens	Reactome	ER degradation-enhancing alpha-mannosidase-like protein 1	20260222
UniProtKB	Q92611	EDEM1	located_in	GO:0005783	endoplasmic reticulum	cellular_component	ECO:0000314	IDA	GO_REF:0000052		9606	Homo sapiens	HPA	ER degradation-enhancing alpha-mannosidase-like protein 1	20251115
UniProtKB	Q92611	EDEM1	involved_in	GO:1904380	endoplasmic reticulum mannose trimming	biological_process	ECO:0000315	IMP	PMID:25092655		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20250604
UniProtKB	Q92611	EDEM1	involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	biological_process	ECO:0000315	IMP	PMID:25092655		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20231121
UniProtKB	Q92611	EDEM1	involved_in	GO:0036503	ERAD pathway	biological_process	ECO:0000315	IMP	PMID:21062743		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20231121
UniProtKB	Q92611	EDEM1	involved_in	GO:0036503	ERAD pathway	biological_process	ECO:0000315	IMP	PMID:25092655		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20231121
UniProtKB	Q92611	EDEM1	involved_in	GO:1904382	mannose trimming involved in glycoprotein ERAD pathway	biological_process	ECO:0000304	TAS	Reactome:R-HSA-6782685		9606	Homo sapiens	Reactome	ER degradation-enhancing alpha-mannosidase-like protein 1	20230308
UniProtKB	Q92611	EDEM1	located_in	GO:0044322	endoplasmic reticulum quality control compartment	cellular_component	ECO:0000314	IDA	PMID:23233672		9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20200911
UniProtKB	Q92611	EDEM1	involved_in	GO:0045047	protein targeting to ER	biological_process	ECO:0000315	IMP	PMID:23233672		9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20200911
UniProtKB	Q92611	EDEM1	enables	GO:0051787	misfolded protein binding	molecular_function	ECO:0000315	IMP	PMID:23233672		9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20200911
UniProtKB	Q92611	EDEM1	enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	molecular_function	ECO:0000315	IMP	PMID:25092655		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20150623
UniProtKB	Q92611	EDEM1	involved_in	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	biological_process	ECO:0000315	IMP	PMID:24200403		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20150609
UniProtKB	Q92611	EDEM1	involved_in	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol	biological_process	ECO:0000316	IGI	PMID:24200403	UniProtKB:Q9BV94	9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20150609
UniProtKB	Q92611	EDEM1	located_in	GO:0044322	endoplasmic reticulum quality control compartment	cellular_component	ECO:0000304	TAS	Reactome:R-HSA-1791155		9606	Homo sapiens	Reactome	ER degradation-enhancing alpha-mannosidase-like protein 1	20150608
UniProtKB	Q92611	EDEM1	located_in	GO:0044322	endoplasmic reticulum quality control compartment	cellular_component	ECO:0000304	TAS	Reactome:R-HSA-6782685		9606	Homo sapiens	Reactome	ER degradation-enhancing alpha-mannosidase-like protein 1	20150608
UniProtKB	Q92611	EDEM1	located_in	GO:0005783	endoplasmic reticulum	cellular_component	ECO:0000315	IMP	PMID:21062743		9606	Homo sapiens	ParkinsonsUK-UCL	ER degradation-enhancing alpha-mannosidase-like protein 1	20150602
UniProtKB	Q92611	EDEM1	located_in	GO:0005783	endoplasmic reticulum	cellular_component	ECO:0000314	IDA	PMID:24200403		9606	Homo sapiens	MGI	ER degradation-enhancing alpha-mannosidase-like protein 1	20150216
UniProtKB	Q92611	EDEM1	NOT|enables	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	molecular_function	ECO:0000314	IDA	PMID:12610306		9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20110412
UniProtKB	Q92611	EDEM1	enables	GO:0005515	protein binding	molecular_function	ECO:0000353	IPI	PMID:19524542	UniProtKB:Q9UBV2	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20100215
UniProtKB	Q92611	EDEM1	enables	GO:0005515	protein binding	molecular_function	ECO:0000353	IPI	PMID:19934218	UniProtKB:P08100	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20100215
UniProtKB	Q92611	EDEM1	enables	GO:0051787	misfolded protein binding	molecular_function	ECO:0000314	IDA	PMID:19524542		9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20100215
UniProtKB	Q92611	EDEM1	enables	GO:0005515	protein binding	molecular_function	ECO:0000353	IPI	PMID:16449189	UniProtKB:Q96Q80	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20060227
UniProtKB	Q92611	EDEM1	enables	GO:0005515	protein binding	molecular_function	ECO:0000353	IPI	PMID:16449189	UniProtKB:Q9GZP9	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20060227
UniProtKB	Q92611	EDEM1	located_in	GO:0005789	endoplasmic reticulum membrane	cellular_component	ECO:0000250	ISS	GO_REF:0000024	UniProtKB:Q925U4	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20040709
UniProtKB	Q92611	EDEM1	involved_in	GO:0036503	ERAD pathway	biological_process	ECO:0000250	ISS	GO_REF:0000024	UniProtKB:Q925U4	9606	Homo sapiens	UniProt	ER degradation-enhancing alpha-mannosidase-like protein 1	20040709