| Paper | Publication date | Topic | Key findings | Key quantitative results | URL | Citation |
|---|---|---|---|---|---|---|
| Murase et al., *Regulation of the ER-Resident Mannosidase EDEM2 in HEK293 Cells* | Jan 2023 | Regulation | EDEM2 is an ER-resident initiator mannosidase whose expression is modestly induced by ER stress but regulated strongly post-transcriptionally; TXNDC11 supports EDEM2 stability, and EDEM2 is at least partly turned over by SEL1L-mediated ERAD | EDEM2 mRNA decreased ~30% after 6 h MG132/CMA/CHX; EDEM2 protein decreased ~50% after 24 h CHX; TXNDC11 deficiency reduced EDEM2 protein; DTT-induced loss was partly rescued by MG132 or SEL1L deficiency | https://doi.org/10.1248/bpbreports.6.6_193 | (pqac-00000011, pqac-00000012) |
| Wu et al., *EDEM2 is a diagnostic and prognostic biomarker and associated with immune infiltration in glioma: A comprehensive analysis* | Jan 2023 | Disease biomarker | EDEM2 is overexpressed in glioma, associated with poor prognosis, immune infiltration, and greater invasiveness; knockdown reduced U251 migration/invasion; high EDEM2 associated with ICI response and higher TMB | Nomogram C-index = 0.847; ICI-response AUCs = 0.857 and 0.839; diagnostic AUC = 0.988 for pathological grade and 0.673 for IDH status; TMB correlation r = 0.473, p < 0.001; mutation frequency 0.4% in LGG and 0.7% in GBM | https://doi.org/10.3389/fonc.2022.1054012 | (pqac-00000008, pqac-00000010, pqac-00000016) |
| Ninagawa et al., *UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins* | Sep 2024 | Mechanism / pathway update | Updated ERQC model in which UGGT1-driven reglucosylation competes with EDEM-mediated mannose trimming; EDEM2 is the initiating M9→M8B step, upstream of EDEM3/EDEM1 and OS9/XTP3B delivery to SEL1L-HRD1 | UGGT1-KO and UGGT-DKO accelerated degradation of ATF6α and NHK; UGGT2-KO had little effect; degradation was blocked in SEL1L-KO and EDEM-TKO cells; kifunensine stabilized ATF6α in UGGT-DKO; no EDEM2-specific numeric AUC/correlation metrics reported | https://doi.org/10.1101/2023.10.18.562958 | (pqac-00000013, pqac-00000014, pqac-00000015, pqac-00000017) |


*Table: This table lists the 2023-2024 EDEM2-related papers identified in the current evidence set, organized by topic and publication date. It highlights the most useful quantitative results and pathway-level takeaways for mechanism, regulation, and biomarker interpretation.*