EGF encodes a type I transmembrane precursor that is proteolytically processed to release mature epidermal growth factor, a secreted ligand for EGFR-family receptor tyrosine kinases. Mature EGF binds EGFR and promotes ligand-induced receptor dimerization and autophosphorylation, activating ERBB signaling outputs such as the RAS-RAF-MEK-ERK cascade and PI3K-AKT signaling in epithelial and other responsive tissues.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001525 angiogenesis | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | KEEP AS NON CORE | Summary: EGF can stimulate endothelial proliferation, migration, tube formation, PI3K-AKT signaling, and angiogenic responses in appropriate endothelial contexts. Reason: These are biologically plausible outputs of EGF-EGFR signaling but are tissue and assay contexts downstream of the core ligand activity. |
| GO:0001938 positive regulation of endothelial cell proliferation | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: EGF can stimulate endothelial proliferation, migration, tube formation, PI3K-AKT signaling, and angiogenic responses in appropriate endothelial contexts. Reason: These are biologically plausible outputs of EGF-EGFR signaling but are tissue and assay contexts downstream of the core ligand activity. |
| GO:0002092 positive regulation of receptor internalization | IDA PMID:22732145 Diacylglycerol kinase ΞΈ counteracts protein kinase C-mediate... | KEEP AS NON CORE | Summary: Ligand binding by EGF promotes EGFR ubiquitination, internalization, and endosomal trafficking. Reason: EGFR down-regulation is a well-established consequence of EGF stimulation, but the core function remains receptor liganding rather than execution of the endocytic machinery. |
| GO:0005085 guanyl-nucleotide exchange factor activity | IDA PMID:20353436 Epidermal growth factor's activation of Ras is inhibited by ... | REMOVE | Summary: EGF stimulation activates Ras downstream of EGFR but EGF is not a Ras guanine-nucleotide exchange factor. Reason: The cited study measured epidermal growth factor activation of Ras. Nucleotide exchange on Ras is catalyzed by SOS-family GEFs recruited downstream of EGFR, not by the extracellular EGF ligand. |
| GO:0005154 epidermal growth factor receptor binding | IEA GO_REF:0000120 | ACCEPT | Summary: Mature EGF binds the extracellular domain of EGFR. Reason: EGFR binding is the central molecular activity of the EGF ligand, and the reviewed experimental and automated orthology rows all point to this ligand-receptor activity. |
| GO:0005154 epidermal growth factor receptor binding | TAS PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | ACCEPT | Summary: Mature EGF binds the extracellular domain of EGFR. Reason: EGFR binding is the central molecular activity of the EGF ligand, and the reviewed experimental and automated orthology rows all point to this ligand-receptor activity. |
| GO:0005154 epidermal growth factor receptor binding | TAS PMID:9712850 Nerve growth factor regulation of m4 muscarinic receptor mRN... | ACCEPT | Summary: Mature EGF binds the extracellular domain of EGFR. Reason: EGFR binding is the central molecular activity of the EGF ligand, and the reviewed experimental and automated orthology rows all point to this ligand-receptor activity. |
| GO:0005509 calcium ion binding | IEA GO_REF:0000002 | KEEP AS NON CORE | Summary: The EGF precursor has multiple calcium-binding EGF-like domains outside the mature EGFR ligand sequence. Reason: The InterPro-based calcium ion binding call is plausible for the multidomain pro-EGF precursor, but calcium binding is not the defining growth-factor activity of the mature EGF ligand. |
| GO:0005515 protein binding | IPI PMID:12297050 Crystal structure of the complex of human epidermal growth f... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:12620237 EGF activates its receptor by removing interactions that aut... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:17697999 Ligand-induced structural transitions in ErbB receptor extra... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:21439278 Engineered epidermal growth factor mutants with faster bindi... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:21439278 Engineered epidermal growth factor mutants with faster bindi... | REMOVE | Summary: This row asserts only generic protein binding and does not define a specific molecular function of EGF. Reason: GO:0005515 is not informative for EGF. The available evidence describes a peripheral or broad interactome hit rather than a specific EGF ligand activity that can be converted to a better GO molecular-function term. |
| GO:0005515 protein binding | IPI PMID:21822280 Simultaneous visualization of the extracellular and cytoplas... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:23597562 Inhibition of tumor angiogenesis and growth by a small-molec... | UNDECIDED | Summary: The cached record is abstract-only or not specific enough to verify the asserted EGF protein interaction. Reason: Because the supporting full text is not available in the cache, this experimental IPI row should not be removed or rewritten from the title/abstract alone. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: The cached record is abstract-only or not specific enough to verify the asserted EGF protein interaction. Reason: Because the supporting full text is not available in the cache, this experimental IPI row should not be removed or rewritten from the title/abstract alone. |
| GO:0005515 protein binding | IPI PMID:26280537 Secreted and O-GlcNAcylated MIF binds to the human EGF recep... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:2790960 Functional independence of the epidermal growth factor recep... | UNDECIDED | Summary: The cached record is abstract-only or not specific enough to verify the asserted EGF protein interaction. Reason: Because the supporting full text is not available in the cache, this experimental IPI row should not be removed or rewritten from the title/abstract alone. |
| GO:0005515 protein binding | IPI PMID:28988771 EGFR Ligands Differentially Stabilize Receptor Dimers to Spe... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005515 protein binding | IPI PMID:30082873 Insights into the structure and dynamics of lysyl oxidase pr... | REMOVE | Summary: This row asserts only generic protein binding and does not define a specific molecular function of EGF. Reason: GO:0005515 is not informative for EGF. The available evidence describes a peripheral or broad interactome hit rather than a specific EGF ligand activity that can be converted to a better GO molecular-function term. |
| GO:0005515 protein binding | IPI PMID:30083275 The S100A4 Protein Signals through the ErbB4 Receptor to Pro... | REMOVE | Summary: This row asserts only generic protein binding and does not define a specific molecular function of EGF. Reason: GO:0005515 is not informative for EGF. The available evidence describes a peripheral or broad interactome hit rather than a specific EGF ligand activity that can be converted to a better GO molecular-function term. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: This row asserts only generic protein binding and does not define a specific molecular function of EGF. Reason: GO:0005515 is not informative for EGF. The available evidence describes a peripheral or broad interactome hit rather than a specific EGF ligand activity that can be converted to a better GO molecular-function term. |
| GO:0005515 protein binding | IPI PMID:9135143 Activation of HER4 by heparin-binding EGF-like growth factor... | MODIFY | Summary: The cited interaction is the specific EGF-EGFR ligand-receptor interaction, not an unqualified protein-binding activity. Reason: Generic GO:0005515 is uninformative for the EGF ligand. These structural and biochemical EGFR papers support replacement with the specific molecular function GO:0005154 epidermal growth factor receptor binding. Proposed replacements: epidermal growth factor receptor binding |
| GO:0005576 extracellular region | HDA PMID:16502470 Human colostrum: identification of minor proteins in the aqu... | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | IDA PMID:11336639 Heterodimerization of the epidermal-growth-factor (EGF) rece... | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | IDA PMID:11336639 Heterodimerization of the epidermal-growth-factor (EGF) rece... | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | IEA GO_REF:0000120 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1169421 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1220610 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1220611 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1220612 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1220613 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225947 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225949 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225950 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225951 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225952 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225956 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225957 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225960 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225961 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1225978 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1226012 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1226014 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1226016 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1247841 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1247842 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1247844 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1250195 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1306957 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1306963 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1306965 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177922 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177923 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177924 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177925 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177926 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177927 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177930 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177933 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177934 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177935 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177936 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177937 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177938 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177939 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177941 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177942 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177943 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177944 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-177945 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-182969 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-182986 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-182990 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-182993 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-182994 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183002 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183036 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183051 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183055 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183058 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183067 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183072 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183084 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-183089 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1963563 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1963581 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1963582 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1963586 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1963589 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1977959 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-212706 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-212710 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-212713 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-481007 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5638137 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-6785636 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-6785648 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8847995 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8848005 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8863804 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8864029 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8864105 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8864125 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8866279 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8867041 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8867044 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8867047 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8867754 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8867756 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868071 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868072 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868230 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868236 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868648 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868651 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8868661 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-8951490 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9018572 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9018573 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9625482 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9625487 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664567 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664588 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664918 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664933 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664940 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664950 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664976 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664983 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9664991 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665000 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665009 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665032 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665034 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665388 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665389 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665404 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665406 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665407 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665408 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665409 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665410 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665411 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665413 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665415 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665416 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665417 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665697 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665698 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665699 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665700 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665701 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665704 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665705 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665706 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665707 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9665709 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9796044 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-NUL-1248744 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-NUL-1251923 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005576 extracellular region | TAS Reactome:R-NUL-1251929 | ACCEPT | Summary: EGF is a membrane precursor that releases a mature extracellular ligand; this row places the EGF ligand or EGF-containing ERBB complex in the extracellular region. Reason: The extracellular-region annotation is consistent with the cleaved mature growth factor, and with Reactome events in which EGF is the extracellular ligand bound to EGFR or ERBB heterodimers. |
| GO:0005765 lysosomal membrane | HDA PMID:17897319 Integral and associated lysosomal membrane proteins. | KEEP AS NON CORE | Summary: EGF was detected in a high-throughput placental lysosomal-membrane proteome. Reason: This HDA row is retained as a proteomic localization observation, but lysosomal membrane localization is not a core site of EGF ligand action. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Pro-EGF is a single-pass membrane precursor at the cell surface before extracellular release of mature EGF. Reason: Plasma-membrane localization is biologically appropriate for the EGF precursor and conserved across mammalian EGF orthologs. |
| GO:0005886 plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: Pro-EGF is a single-pass membrane precursor at the cell surface before extracellular release of mature EGF. Reason: Plasma-membrane localization is biologically appropriate for the EGF precursor and conserved across mammalian EGF orthologs. |
| GO:0005886 plasma membrane | TAS PMID:3491360 Human epidermal growth factor precursor: cDNA sequence, expr... | ACCEPT | Summary: Pro-EGF is a single-pass membrane precursor at the cell surface before extracellular release of mature EGF. Reason: Plasma-membrane localization is biologically appropriate for the EGF precursor and conserved across mammalian EGF orthologs. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:18567582 IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:20353436 Epidermal growth factor's activation of Ras is inhibited by ... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IMP PMID:22732145 Diacylglycerol kinase ΞΈ counteracts protein kinase C-mediate... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0008083 growth factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0008083 growth factor activity | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0008083 growth factor activity | IDA PMID:7736574 Three distinct IL-2 signaling pathways mediated by bcl-2, c-... | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:20388803 The chemokine receptor CXCR7 is highly expressed in human gl... | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:7736574 Three distinct IL-2 signaling pathways mediated by bcl-2, c-... | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:18722344 BCAR3 regulates EGF-induced DNA synthesis in normal human br... | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0010595 positive regulation of endothelial cell migration | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: EGF can stimulate endothelial proliferation, migration, tube formation, PI3K-AKT signaling, and angiogenic responses in appropriate endothelial contexts. Reason: These are biologically plausible outputs of EGF-EGFR signaling but are tissue and assay contexts downstream of the core ligand activity. |
| GO:0010628 positive regulation of gene expression | IDA PMID:25678558 Navigator-3, a modulator of cell migration, may act as a sup... | MARK AS OVER ANNOTATED | Summary: EGF-induced ERK signaling can alter transcriptional regulator activity, but EGF itself does not directly regulate gene expression. Reason: This is an over-propagated downstream readout of EGFR/MAPK signaling. The extracellular ligand initiates the pathway but does not execute DNA-templated transcription or gene-expression regulation. |
| GO:0010800 positive regulation of peptidyl-threonine phosphorylation | IDA PMID:16314496 Activation of TRAP/mediator subunit TRAP220/Med1 is regulate... | MARK AS OVER ANNOTATED | Summary: EGF stimulation can induce MAPK-dependent threonine phosphorylation of downstream proteins. Reason: This phosphorylation is catalyzed by downstream kinases such as ERK, not by EGF. Capturing the broad phosphorylation readout as an EGF biological process overstates the ligand role. |
| GO:0016020 membrane | IEA GO_REF:0000044 | ACCEPT | Summary: Pro-EGF is a single-pass type I membrane protein. Reason: The UniProt subcellular-location mapping to membrane is correct for the uncleaved EGF precursor. |
| GO:0030297 transmembrane receptor protein tyrosine kinase activator activity | IDA PMID:11336639 Heterodimerization of the epidermal-growth-factor (EGF) rece... | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0030297 transmembrane receptor protein tyrosine kinase activator activity | TAS PMID:9712850 Nerve growth factor regulation of m4 muscarinic receptor mRN... | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0030335 positive regulation of cell migration | IDA PMID:25678558 Navigator-3, a modulator of cell migration, may act as a sup... | KEEP AS NON CORE | Summary: EGF stimulation can promote epithelial cell migration in specific growth-factor response assays. Reason: Cell migration is a downstream outcome of EGF-EGFR signaling and is retained as non-core rather than as the direct molecular role of EGF. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8868658 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8868659 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8868660 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8868661 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8869438 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8871193 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0030669 clathrin-coated endocytic vesicle membrane | TAS Reactome:R-HSA-8871194 | KEEP AS NON CORE | Summary: Internalized EGF:EGFR complexes can enter clathrin-coated vesicles during receptor down-regulation. Reason: This location is a trafficking state of ligand-bound EGFR, not the defining site of EGF action, so it is retained as a non-core consequence of EGF-induced receptor endocytosis. |
| GO:0031093 platelet alpha granule lumen | TAS Reactome:R-HSA-481007 | KEEP AS NON CORE | Summary: Reactome includes EGF among platelet alpha-granule growth-factor cargo. Reason: Platelet granule storage is a valid secretory reservoir for EGF but not the core molecular function of the ligand. |
| GO:0038134 ERBB2-EGFR signaling pathway | IDA PMID:11336639 Heterodimerization of the epidermal-growth-factor (EGF) rece... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0038134 ERBB2-EGFR signaling pathway | IDA PMID:11336639 Heterodimerization of the epidermal-growth-factor (EGF) rece... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0038134 ERBB2-EGFR signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0042327 positive regulation of phosphorylation | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | MARK AS OVER ANNOTATED | Summary: EGF stimulation causes EGFR and downstream kinases to phosphorylate many targets. Reason: Positive regulation of phosphorylation is true only as a broad downstream readout of receptor activation and is less informative than the accepted EGFR signaling and MAPK-cascade annotations. |
| GO:0043388 positive regulation of DNA binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Mouse EGF evidence supports growth-factor effects on nuclear DNA-binding regulators downstream of EGFR. Reason: The orthologous transfer is plausible but represents a distal transcriptional response to EGF signaling, not a core ligand function. |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:18567582 IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0043410 positive regulation of MAPK cascade | IEA GO_REF:0000117 | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0043410 positive regulation of MAPK cascade | IMP PMID:18722344 BCAR3 regulates EGF-induced DNA synthesis in normal human br... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0045840 positive regulation of mitotic nuclear division | IDA PMID:15611079 Epigen, the last ligand of ErbB receptors, reveals intricate... | KEEP AS NON CORE | Summary: EGF is mitogenic in responsive cell types. Reason: Cell proliferation and mitotic entry are classic downstream responses to EGF-EGFR signaling, but they are downstream cellular outcomes rather than the direct ligand activity itself. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:16314496 Activation of TRAP/mediator subunit TRAP220/Med1 is regulate... | MARK AS OVER ANNOTATED | Summary: EGF-induced ERK signaling can alter transcriptional regulator activity, but EGF itself does not directly regulate gene expression. Reason: This is an over-propagated downstream readout of EGFR/MAPK signaling. The extracellular ligand initiates the pathway but does not execute DNA-templated transcription or gene-expression regulation. |
| GO:0046425 regulation of receptor signaling pathway via JAK-STAT | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: EGF-EGFR signaling can crosstalk with JAK-STAT pathway activity. Reason: JAK-STAT regulation is retained as an orthology-supported secondary output rather than a defining EGF pathway. |
| GO:0046425 regulation of receptor signaling pathway via JAK-STAT | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: EGF-EGFR signaling can crosstalk with JAK-STAT pathway activity. Reason: JAK-STAT regulation is retained as an orthology-supported secondary output rather than a defining EGF pathway. |
| GO:0048018 receptor ligand activity | IDA PMID:11336639 Heterodimerization of the epidermal-growth-factor (EGF) rece... | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0048018 receptor ligand activity | IEA GO_REF:0000107 | ACCEPT | Summary: EGF is a growth-factor ligand that binds and activates EGFR. Reason: Receptor ligand activity through EGFR is the direct molecular function of mature EGF, so this ligand-activity annotation is core. |
| GO:0051048 negative regulation of secretion | IDA PMID:10559227 ErbB2 and ErbB3 receptors mediate inhibition of calcium-depe... | KEEP AS NON CORE | Summary: EGF can inhibit calcium-dependent chloride secretion in colonic epithelial cells through ERBB-family signaling. Reason: This is a specific epithelial physiology output of EGF signaling rather than the core function of the growth-factor ligand. |
| GO:0051049 regulation of transport | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: Regulation of transport is too broad to usefully describe EGF function. Reason: The ARBA term likely reflects assorted downstream transport effects of EGFR signaling and should not be retained as a precise EGF process annotation. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: EGF can stimulate endothelial proliferation, migration, tube formation, PI3K-AKT signaling, and angiogenic responses in appropriate endothelial contexts. Reason: These are biologically plausible outputs of EGF-EGFR signaling but are tissue and assay contexts downstream of the core ligand activity. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IGI PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: EGF can stimulate endothelial proliferation, migration, tube formation, PI3K-AKT signaling, and angiogenic responses in appropriate endothelial contexts. Reason: These are biologically plausible outputs of EGF-EGFR signaling but are tissue and assay contexts downstream of the core ligand activity. |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: EGF has been detected in human urinary or prostatic extracellular-vesicle proteomes. Reason: Extracellular exosome is retained as a non-core proteomics-supported location and does not supersede extracellular region or plasma membrane as the main EGF localizations. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: EGF has been detected in human urinary or prostatic extracellular-vesicle proteomes. Reason: Extracellular exosome is retained as a non-core proteomics-supported location and does not supersede extracellular region or plasma membrane as the main EGF localizations. |
| GO:0070062 extracellular exosome | IDA PMID:21082674 Comprehensive analysis of low-abundance proteins in human ur... | KEEP AS NON CORE | Summary: EGF has been detected in human urinary or prostatic extracellular-vesicle proteomes. Reason: Extracellular exosome is retained as a non-core proteomics-supported location and does not supersede extracellular region or plasma membrane as the main EGF localizations. |
| GO:0070371 ERK1 and ERK2 cascade | IDA PMID:16314496 Activation of TRAP/mediator subunit TRAP220/Med1 is regulate... | ACCEPT | Summary: EGF binding activates EGFR-family receptors and their downstream RAS-RAF-MEK-ERK signaling cascade. Reason: These signaling annotations capture the direct pathway initiated by the EGF ligand through EGFR, including EGFR-ERBB2 heterodimers and MAPK/ERK output. |
| GO:0090263 positive regulation of canonical Wnt signaling pathway | IDA PMID:20302655 Epidermal growth factor receptor regulates beta-catenin loca... | KEEP AS NON CORE | Summary: EGF-EGFR stimulation can feed into Wnt/beta-catenin, calcium-entry, cholesterol-efflux, or surface-localization outputs depending on cell type. Reason: These rows describe specialized downstream pathway crosstalk or trafficking consequences and are therefore retained as non-core. |
| GO:0090279 regulation of calcium ion import | IDA PMID:19996314 Cell-cell contact formation governs Ca2+ signaling by TRPC4 ... | KEEP AS NON CORE | Summary: EGF-EGFR stimulation can feed into Wnt/beta-catenin, calcium-entry, cholesterol-efflux, or surface-localization outputs depending on cell type. Reason: These rows describe specialized downstream pathway crosstalk or trafficking consequences and are therefore retained as non-core. |
| GO:0090370 negative regulation of cholesterol efflux | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: EGF-EGFR stimulation can feed into Wnt/beta-catenin, calcium-entry, cholesterol-efflux, or surface-localization outputs depending on cell type. Reason: These rows describe specialized downstream pathway crosstalk or trafficking consequences and are therefore retained as non-core. |
| GO:0160108 animal gross anatomical part developmental process | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: EGF signaling affects animal tissue development, but this ARBA term is an extremely broad developmental assertion. Reason: The annotation is not grossly false, but it loses the mechanistic specificity of EGF receptor ligand activity and EGFR signaling. |
| GO:1900127 positive regulation of hyaluronan biosynthetic process | IDA PMID:17324121 Growth factor regulation of hyaluronan synthesis and degrada... | UNDECIDED | Summary: The available cached abstract for the cited paper emphasizes PDGF-BB-driven hyaluronan synthesis and does not verify the EGF-specific experiment. Reason: Because this is an experimental IDA annotation and the relevant full text is unavailable in the cache, the row is left undecided rather than second-guessed from the abstract alone. |
| GO:1902966 positive regulation of protein localization to early endosome | IDA PMID:22298428 The Ankrd 13 family of UIM-bearing proteins regulates EGF re... | KEEP AS NON CORE | Summary: Ligand binding by EGF promotes EGFR ubiquitination, internalization, and endosomal trafficking. Reason: EGFR down-regulation is a well-established consequence of EGF stimulation, but the core function remains receptor liganding rather than execution of the endocytic machinery. |
| GO:1905278 positive regulation of epithelial tube formation | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: EGF can stimulate endothelial proliferation, migration, tube formation, PI3K-AKT signaling, and angiogenic responses in appropriate endothelial contexts. Reason: These are biologically plausible outputs of EGF-EGFR signaling but are tissue and assay contexts downstream of the core ligand activity. |
| GO:2000008 regulation of protein localization to cell surface | IDA PMID:19996314 Cell-cell contact formation governs Ca2+ signaling by TRPC4 ... | KEEP AS NON CORE | Summary: EGF-EGFR stimulation can feed into Wnt/beta-catenin, calcium-entry, cholesterol-efflux, or surface-localization outputs depending on cell type. Reason: These rows describe specialized downstream pathway crosstalk or trafficking consequences and are therefore retained as non-core. |
| GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ligand binding by EGF promotes EGFR ubiquitination, internalization, and endosomal trafficking. Reason: EGFR down-regulation is a well-established consequence of EGF stimulation, but the core function remains receptor liganding rather than execution of the endocytic machinery. |
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