| Citation (author, year) | Publication date/month | Venue | Main finding relevant to EIF2B4 | URL | Evidence IDs |
|---|---|---|---|---|---|
| Wek et al., 2023 | Aug 2023 | *Antioxidants & Redox Signaling* | Authoritative ISR review: eIF2B is the GEF for eIF2; phosphorylation of eIF2α inhibits eIF2B-mediated GDP→GTP exchange, lowering ternary-complex formation and reprogramming translation. While not EIF2B4-specific, it provides current consensus framework for the regulatory role of eIF2Bδ within ISR control. | https://doi.org/10.1089/ars.2022.0123 | (pqac-00000016, pqac-00000029) |
| Hanson et al., 2024 | Sep 2024 | *iScience* | Peer-reviewed cell-biology study showing eIF2B localizes to cytoplasmic eIF2B bodies with cell-type-specific composition; eIF2Bδ is present in both small and large bodies, and its redistribution changes with stress and ISRIB treatment, supporting a localization-dependent regulatory role for EIF2B4 in neurons and glia. | https://doi.org/10.1016/j.isci.2024.110851 | (pqac-00000005, pqac-00000011, pqac-00000012, pqac-00000030) |
| Gupta et al., 2023 | Apr 2023 | *Proceedings of the National Academy of Sciences of the USA (PNAS)* | Demonstrates that overexpression of eIF2Bδ in breast cancer stem cells suppresses strong ISR induction through preferential interaction with phospho-eIF2α, sustaining eIF2B activity and promoting invasion/metastasis; identifies EIF2B4/eIF2Bδ as functionally important in cancer stress adaptation. | https://doi.org/10.1073/pnas.2207898120 | (pqac-00000028) |
| Escobar-Pacheco et al., 2024 | Jul 2024 | *Cureus* | Systematic review and case report on ovarioleukodystrophy due to EIF2B genes: 20 worldwide cases compiled, median onset 19 years, with missense variants predominating and EIF2B4/EIF2B5 notably represented; supports the clinical relevance of EIF2B4 in adult and adolescent VWM-spectrum disease. | https://doi.org/10.7759/cureus.64497 | (pqac-00000017, pqac-00000018, pqac-00000019, pqac-00000022) |
| Dong et al., 2023 | Nov 2023 | *Italian Journal of Pediatrics* | Pediatric white-matter-disorder cohort identifying EIF2B4 among causal genes, including a novel splice-site variant c.885+2T>G; supports ongoing discovery of pathogenic EIF2B4 alleles in leukodystrophy diagnostics. | https://doi.org/10.1186/s13052-023-01555-z | (pqac-00000023) |
| Wortham et al., 2014 | May 2014 | *The FASEB Journal* | Foundational structural/biochemical study showing eIF2B is a heterodecamer and placing eIF2Bδ among the α/β/δ regulatory subunits that support decamer assembly and full holoenzyme function; provides key experimental basis for interpreting EIF2B4’s scaffold/regulatory role. | https://doi.org/10.1096/fj.13-243329 | (pqac-00000002, pqac-00000004, pqac-00000007, pqac-00000008) |


*Table: This table summarizes core recent and foundational publications needed to interpret human EIF2B4/eIF2Bδ function, localization, ISR biology, and disease relevance. It is useful as a citation-ready literature map for the final research report.*