GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB O60573 EIF4E2 enables GO:0000340 RNA 7-methylguanosine cap binding molecular_function ECO:0000318 IBA GO_REF:0000033 FB:FBgn0015218|FB:FBgn0035709|FB:FBgn0035823|FB:FBgn0039622|FB:FBgn0040368|FB:FBgn0053100|FB:FBgn0265089|PANTHER:PTN000238660|UniProtKB:E9ADE1|UniProtKB:O60573|UniProtKB:P06730|UniProtKB:Q38B99|UniProtKB:Q4Q813|UniProtKB:Q57V43|WB:WBGene00002059|WB:WBGene00002060|WB:WBGene00002061|WB:WBGene00002062|WB:WBGene00002063|ZFIN:ZDB-GENE-040413-1 9606 Homo sapiens GO_Central Eukaryotic translation initiation factor 4E type 2 20250903 UniProtKB O60573 EIF4E2 enables GO:0003743 translation initiation factor activity molecular_function ECO:0000318 IBA GO_REF:0000033 CGD:CAL0000195194|FB:FBgn0015218|FB:FBgn0035709|FB:FBgn0035823|FB:FBgn0040368|MGI:MGI:95305|PANTHER:PTN000238660|UniProtKB:O97266|UniProtKB:P06730|ZFIN:ZDB-GENE-040413-1 9606 Homo sapiens GO_Central Eukaryotic translation initiation factor 4E type 2 20250903 UniProtKB O60573 EIF4E2 involved_in GO:0006413 translational initiation biological_process ECO:0000318 IBA GO_REF:0000033 CGD:CAL0000195194|FB:FBgn0015218|FB:FBgn0035709|FB:FBgn0035823|FB:FBgn0040368|MGI:MGI:95305|PANTHER:PTN000238660|UniProtKB:O97266|ZFIN:ZDB-GENE-040413-1 9606 Homo sapiens GO_Central Eukaryotic translation initiation factor 4E type 2 20250903 UniProtKB O60573 EIF4E2 part_of GO:0016281 eukaryotic translation initiation factor 4F complex cellular_component ECO:0000318 IBA GO_REF:0000033 FB:FBgn0015218|FB:FBgn0035709|FB:FBgn0035823|FB:FBgn0040368|FB:FBgn0053100|FB:FBgn0265089|PANTHER:PTN000238660|RGD:69647|SGD:S000005499|UniProtKB:P06730|UniProtKB:Q38B99|UniProtKB:Q4Q7R3|UniProtKB:Q57V43 9606 Homo sapiens GO_Central Eukaryotic translation initiation factor 4E type 2 20250903 UniProtKB O60573 EIF4E2 located_in GO:0000932 P-body cellular_component ECO:0007322 IEA GO_REF:0000044 UniProtKB-SubCell:SL-0230 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20260601 UniProtKB O60573 EIF4E2 enables GO:0003723 RNA binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR001040|InterPro:IPR019770 9606 Homo sapiens InterPro Eukaryotic translation initiation factor 4E type 2 20260601 UniProtKB O60573 EIF4E2 enables GO:0003743 translation initiation factor activity molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR001040|InterPro:IPR019770 9606 Homo sapiens InterPro Eukaryotic translation initiation factor 4E type 2 20260601 UniProtKB O60573 EIF4E2 located_in GO:0005737 cytoplasm cellular_component ECO:0000501 IEA GO_REF:0000120 InterPro:IPR019770|UniProtKB-SubCell:SL-0086 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20260601 UniProtKB O60573 EIF4E2 involved_in GO:0006413 translational initiation biological_process ECO:0000256 IEA GO_REF:0000002 InterPro:IPR001040|InterPro:IPR019770 9606 Homo sapiens InterPro Eukaryotic translation initiation factor 4E type 2 20260601 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:15094042 UniProtKB:Q13541 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:15161933 UniProtKB:P63104 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:16189514 UniProtKB:Q9NRA8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19060904 UniProtKB:Q9NRA8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:22678294 UniProtKB:Q99814 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:A1A4E9 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O43597 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:O75478 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P08727 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P14373 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P15173 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P15884 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P60370 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P60410 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:P60411 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q01850 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q04864 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q08117 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q15323 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q5T124 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q6A162 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q6UY14-3 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q70EL1 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q7Z3S9 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q7Z6G3-2 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8IX15-3 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8N6Y0 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8NA61 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q8TD10 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96C00 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q96R06 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BRK4 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9BYV2 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9GZV8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9H257 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9UPY8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9Y2J4-4 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25416956 UniProtKB:Q9Y5V3 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:25959826 UniProtKB:P42858 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:28514442 UniProtKB:Q9NRA8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:31515488 UniProtKB:P15173 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:31515488 UniProtKB:Q96C00 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:32814053 UniProtKB:P42858 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q13541 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q9NRA8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:35271311 UniProtKB:P63104 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:40205054 UniProtKB:Q9NRA8 9606 Homo sapiens IntAct Eukaryotic translation initiation factor 4E type 2 20260530 UniProtKB O60573 EIF4E2 located_in GO:0005829 cytosol cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Eukaryotic translation initiation factor 4E type 2 20251115 UniProtKB O60573 EIF4E2 involved_in GO:1990261 pre-mRNA catabolic process biological_process ECO:0005547 NAS PMID:33053355 9606 Homo sapiens ComplexPortal Eukaryotic translation initiation factor 4E type 2 20250731 UniProtKB O60573 EIF4E2 enables GO:0098808 mRNA cap binding molecular_function ECO:0000314 IDA PMID:17368478 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20231201 UniProtKB O60573 EIF4E2 enables GO:0000340 RNA 7-methylguanosine cap binding molecular_function ECO:0000314 IDA PMID:35878012 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20230221 UniProtKB O60573 EIF4E2 involved_in GO:0045947 negative regulation of translational initiation biological_process ECO:0000314 IDA PMID:32726578 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20230221 UniProtKB O60573 EIF4E2 involved_in GO:0045947 negative regulation of translational initiation biological_process ECO:0000314 IDA PMID:35878012 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20230221 UniProtKB O60573 EIF4E2 involved_in GO:0060339 negative regulation of type I interferon-mediated signaling pathway biological_process ECO:0000314 IDA PMID:35878012 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20230221 UniProtKB O60573 EIF4E2 involved_in GO:0072344 rescue of stalled cytosolic ribosome biological_process ECO:0000314 IDA PMID:32726578 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20230221 UniProtKB O60573 EIF4E2 acts_upstream_of_positive_effect GO:0035278 miRNA-mediated gene silencing by inhibition of translation biological_process ECO:0000314 IDA PMID:28487484 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20220221 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:31439631 UniProtKB:Q6Y7W6 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20210315 UniProtKB O60573 EIF4E2 located_in GO:0000932 P-body cellular_component ECO:0000314 IDA PMID:23991149 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20200807 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:23991149 UniProtKB:Q9NRA8 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20200807 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:28487484 UniProtKB:Q9NRA8 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20200807 UniProtKB O60573 EIF4E2 located_in GO:0005737 cytoplasm cellular_component ECO:0000314 IDA PMID:23991149 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20200807 UniProtKB O60573 EIF4E2 enables GO:0003723 RNA binding molecular_function ECO:0007005 HDA PMID:22681889 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20140203 UniProtKB O60573 EIF4E2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1678842 9606 Homo sapiens Reactome Eukaryotic translation initiation factor 4E type 2 20130528 UniProtKB O60573 EIF4E2 located_in GO:0005829 cytosol cellular_component ECO:0000304 TAS Reactome:R-HSA-1678843 9606 Homo sapiens Reactome Eukaryotic translation initiation factor 4E type 2 20130528 UniProtKB O60573 EIF4E2 acts_upstream_of_or_within GO:0017148 negative regulation of translation biological_process ECO:0000315 IMP PMID:22751931 9606 Homo sapiens MGI Eukaryotic translation initiation factor 4E type 2 20130211 UniProtKB O60573 EIF4E2 enables GO:0031625 ubiquitin protein ligase binding molecular_function ECO:0000353 IPI PMID:14623119 UniProtKB:Q9Y4X5 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20110517 UniProtKB O60573 EIF4E2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:17368478 UniProtKB:Q13541 9606 Homo sapiens UniProt Eukaryotic translation initiation factor 4E type 2 20100429 UniProtKB O60573 EIF4E2 enables GO:0000339 RNA cap binding molecular_function ECO:0000304 TAS PMID:9582349 9606 Homo sapiens PINC Eukaryotic translation initiation factor 4E type 2 20030904 UniProtKB O60573 EIF4E2 enables GO:0008135 translation factor activity, RNA binding molecular_function ECO:0000304 TAS PMID:9582349 9606 Homo sapiens PINC Eukaryotic translation initiation factor 4E type 2 20030904