| Property | Summary for ELAVL3 (HuC; UniProt Q14576) | Supporting citations |
|---|---|---|
| Approved gene / protein name | **ELAVL3** encodes **ELAV-like protein 3**, a neuronal RNA-binding protein in human. Historical name **HuC** is explicitly mapped to ELAVL3 in review literature. | (pqac-00000003, pqac-00000004) |
| Synonyms / aliases | Common aliases include **HuC**; the UniProt-provided aliases for this target are **HUC** and **PLE21**. Literature in the retrieved evidence directly confirms the HuC name for ELAVL3. | (pqac-00000004) |
| Organism / target identity | The reviewed literature matches the intended target: **human ELAVL3/HuC**, a neuronal ELAVL-family RNA-binding protein, with no conflicting gene identity found in the evidence set. | (pqac-00000003, pqac-00000004) |
| Family membership | ELAVL3 belongs to the **neuronal ELAVL (nELAVL)** subgroup together with **ELAVL2/HuB** and **ELAVL4/HuD**; ELAVL1/HuR is the ubiquitous family member. nELAVLs are enriched in the nervous system. | (pqac-00000003, pqac-00000004, pqac-00000001, pqac-00000002) |
| Domain architecture | ELAVL3 shares the canonical ELAVL architecture of **three RNA recognition motifs (RRM1, RRM2, RRM3)** plus a **hinge/linker region** between RRM2 and RRM3. The hinge contributes to protein interactions and nucleocytoplasmic trafficking. | (pqac-00000003, pqac-00000005, pqac-00000012, pqac-00000014) |
| RNA-binding specificity | ELAVL proteins, including ELAVL3, preferentially bind **AU-/U-rich elements** in target RNAs, especially in **3′UTRs**. **RRM1/2** mediate direct binding to AU-rich RNA, whereas **RRM3** contributes to **poly(A)-tail binding** and transcript stabilization. | (pqac-00000002, pqac-00000003, pqac-00000011, pqac-00000012) |
| Core molecular function: mRNA stability | ELAVL3 functions primarily as a **post-transcriptional regulator** that stabilizes target transcripts, in part by binding AU-rich elements and influencing poly(A)-tail-associated protection; ELAVL proteins can multimerize on RNA and oppose destabilizing factors. | (pqac-00000001, pqac-00000003, pqac-00000012) |
| Core molecular function: translation | ELAVL-family proteins regulate **translation** as part of ribonucleoprotein complexes that route RNAs toward translation or decay; RRM3/poly(A)-associated functions connect ELAVL3 to translational control. | (pqac-00000001, pqac-00000003, pqac-00000012) |
| Core molecular function: alternative splicing | ELAVL3 has a documented role in **alternative splicing**; all **three RRMs plus the hinge region** contribute to HuC-dependent splice regulation, and ELAVL3 loss alters neuronal splicing programs linked to excitability. | (pqac-00000005, pqac-00000009, pqac-00000014) |
| Core molecular function: alternative polyadenylation / 3′UTR length | ELAVL3 participates in regulation of **alternative polyadenylation** and **3′UTR length** in neurons. ELAVL3 depletion shifts usage toward **proximal poly(A) sites**, whereas neuronal ELAVL proteins promote longer neuronal 3′UTRs. | (pqac-00000009, pqac-00000013) |
| Biological role emphasis | Current understanding places ELAVL3 as a key **neuronal post-transcriptional regulator** affecting transcript isoform choice, mRNA stability, neuronal differentiation, glutamate-related pathways, and neuronal excitability. | (pqac-00000003, pqac-00000009, pqac-00000010) |
| Typical subcellular localization | ELAVL3 is **predominantly cytoplasmic** but capable of **nucleocytoplasmic shuttling**. A smaller nuclear pool supports roles in splicing and RNA processing, while the hinge/linker region contributes to export/localization control. | (pqac-00000001, pqac-00000003, pqac-00000008, pqac-00000014) |


*Table: This table summarizes the verified identity, family context, domain organization, RNA-binding specificity, molecular functions, and localization of human ELAVL3/HuC. It is useful as a concise reference for functional annotation grounded in the retrieved evidence.*