ELOB

UniProt ID: Q15370
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for ELOB

Existing Annotations Review

GO Term Evidence Action Reason
GO:0070449 elongin complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030891 VCB complex
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000151 ubiquitin ligase complex
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005634 nucleus
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000117 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006368 transcription elongation by RNA polymerase II
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030891 VCB complex
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070449 elongin complex
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:10205047
Structure of the VHL-ElonginC-ElonginB complex: implications... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12004076
Structure of an HIF-1alpha -pVHL complex: hydroxyproline rec... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12050673
Structural basis for the recognition of hydroxyproline in HI... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:12149480
Mammalian mediator subunit mMED8 is an Elongin BC-interactin... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15601820
VHL-box and SOCS-box domains determine binding specificity f... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16189514
Towards a proteome-scale map of the human protein-protein in... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:18323857
NEDD8 acts as a 'molecular switch' defining the functional s... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20211142
An atlas of combinatorial transcriptional regulation in mous... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:20871634
Regulation of receptor for activated C kinase 1 protein by t... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21516116
Next-generation sequencing to generate interactome datasets. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22190034
Global landscape of HIV-human protein complexes. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:27517496
USP9X destabilizes pVHL and promotes cell proliferation. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:30026228
VHL substrate transcription factor ZHX2 as an oncogenic driv... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human ce... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:40205054
Multimodal cell maps as a foundation for structural and func... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016567 protein ubiquitination
IEA
GO_REF:0000041 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IEA
GO_REF:0000107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:40963025
Covariation MS uncovers a protein that controls cysteine cat... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000122 negative regulation of transcription by RNA polymerase II
NAS
PMID:28591624
Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligas... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
NAS
PMID:31273098
A glycine-specific N-degron pathway mediates the quality con... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
NAS
PMID:15601820
VHL-box and SOCS-box domains determine binding specificity f... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
NAS
PMID:21822215
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin li... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
NAS
PMID:22649776
The Role of Elongin BC-Containing Ubiquitin Ligases. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
NAS
PMID:29779948
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Ta... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
NAS
PMID:33398168
Molecular basis for arginine C-terminal degron recognition b... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
NAS
PMID:34743205
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptos... 		PENDING
Summary: TODO: Review this GOA annotation
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
NAS
PMID:33909987
Convergence of mammalian RQC and C-end rule proteolytic path... 		PENDING
Summary: TODO: Review this GOA annotation
GO:2000104 negative regulation of DNA-templated DNA replication
NAS
PMID:22649776
The Role of Elongin BC-Containing Ubiquitin Ligases. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:39039081
Molecular insights into degron recognition by CRL5(ASB7) ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:40440427
ASB7 is a negative regulator of H3K9me3 homeostasis. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031462 Cul2-RING ubiquitin ligase complex
IDA
PMID:35978186
Post-translational control of beige fat biogenesis by PRDM16... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031462 Cul2-RING ubiquitin ligase complex
IDA
PMID:37844242
Molecular basis for C-degron recognition by CRL2(APPBP2) ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
IDA
PMID:37844242
Molecular basis for C-degron recognition by CRL2(APPBP2) ubi... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:35512830
Rab40c regulates focal adhesions and PP6 activity by control... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:37816714
Structure-based design of a phosphotyrosine-masked covalent ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:34857742
Discovery of an exosite on the SOCS2-SH2 domain that enhance... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:21980433
The SOCS2 ubiquitin ligase complex regulates growth hormone ... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:25505247
Biophysical studies on interactions and assembly of full-siz... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:38418882
The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for deg... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:31387940
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines ce... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:32513959
Structure and dynamics of the ASB9 CUL-RING E3 Ligase. 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:23837592
Multimeric complexes among ankyrin-repeat and SOCS-box prote... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:33268465
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligas... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0140958 target-directed miRNA degradation
IMP
PMID:33184237
The ZSWIM8 ubiquitin ligase mediates target-directed microRN... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:22510880
Nuclear receptor binding protein 1 regulates intestinal prog... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0001222 transcription corepressor binding
IPI
PMID:7660122
Inhibition of transcription elongation by the VHL tumor supp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006367 transcription initiation at RNA polymerase II promoter
IDA
PMID:7660122
Inhibition of transcription elongation by the VHL tumor supp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0070449 elongin complex
IDA
PMID:7660122
Inhibition of transcription elongation by the VHL tumor supp... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:21119685
Notch-induced Asb2 expression promotes protein ubiquitinatio... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
ISS
GO_REF:0000024 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:23401859
DCNL1 functions as a substrate sensor and activator of culli... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:26906416
Characterization of the mammalian family of DCN-type NEDD8 E... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1234159 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1234163 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1234173 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1234175 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1234177 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-1234183 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-180540 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-180555 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-180603 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952039 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952625 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8952626 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8955241 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8955289 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8956040 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8956099 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8956103 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-8956106 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9705738 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9755303 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9833107 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9833155 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9954721 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005829 cytosol
TAS
Reactome:R-HSA-9954723 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112379 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112385 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112392 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112395 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112396 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112435 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-112436 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-113411 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-113412 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-113413 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-113414 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-113429 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-1234169 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-1234172 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-1234175 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-6797606 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005654 nucleoplasm
TAS
Reactome:R-HSA-6797616 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031625 ubiquitin protein ligase binding
IDA
PMID:17636018
ASB4 is a hydroxylation substrate of FIH and promotes vascul... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031462 Cul2-RING ubiquitin ligase complex
IDA
PMID:17636018
ASB4 is a hydroxylation substrate of FIH and promotes vascul... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0031466 Cul5-RING ubiquitin ligase complex
IDA
PMID:17636018
ASB4 is a hydroxylation substrate of FIH and promotes vascul... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:15590694
Suppressors of cytokine signaling 4 and 5 regulate epidermal... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0006368 transcription elongation by RNA polymerase II
TAS
PMID:7660129
Elongin (SIII): a multisubunit regulator of elongation by RN... 		PENDING
Summary: TODO: Review this GOA annotation
GO:0065003 protein-containing complex assembly
TAS
PMID:7660129
Elongin (SIII): a multisubunit regulator of elongation by RN... 		PENDING
Summary: TODO: Review this GOA annotation

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000041
Gene Ontology annotation based on UniPathway vocabulary mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10205047
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
PMID:12004076
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
PMID:12050673
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
PMID:12149480
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
PMID:15590694
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
PMID:15601820
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
PMID:17636018
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.
PMID:18323857
NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL.
PMID:20211142
An atlas of combinatorial transcriptional regulation in mouse and man.
PMID:20871634
Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness.
PMID:21119685
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
PMID:21516116
Next-generation sequencing to generate interactome datasets.
PMID:21822215
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
PMID:21980433
The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
PMID:22190034
Global landscape of HIV-human protein complexes.
PMID:22510880
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.
PMID:22649776
The Role of Elongin BC-Containing Ubiquitin Ligases.
PMID:23401859
DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
PMID:23837592
Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:25505247
Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
PMID:26906416
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
PMID:27517496
USP9X destabilizes pVHL and promotes cell proliferation.
PMID:28591624
Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
PMID:29779948
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
PMID:30026228
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
PMID:31273098
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
PMID:31387940
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32513959
Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
PMID:33184237
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
PMID:33268465
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
PMID:33398168
Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.
PMID:33909987
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:34743205
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
PMID:34857742
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
PMID:35271311
OpenCell: Endogenous tagging for the cartography of human cellular organization.
PMID:35512830
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.
PMID:35978186
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
PMID:37816714
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
PMID:37844242
Molecular basis for C-degron recognition by CRL2(APPBP2) ubiquitin ligase.
PMID:38418882
The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.
PMID:39039081
Molecular insights into degron recognition by CRL5(ASB7) ubiquitin ligase.
PMID:40205054
Multimodal cell maps as a foundation for structural and functional genomics.
PMID:40440427
ASB7 is a negative regulator of H3K9me3 homeostasis.
PMID:40963025
Covariation MS uncovers a protein that controls cysteine catabolism.
PMID:7660122
Inhibition of transcription elongation by the VHL tumor suppressor protein.
PMID:7660129
Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.
Reactome:R-HSA-112379
Recruitment of elongation factors to form elongation complex
Reactome:R-HSA-112385
Addition of nucleotides leads to transcript elongation
Reactome:R-HSA-112392
Resumption of elongation after recovery from pausing
Reactome:R-HSA-112395
Abortive termination of elongation after arrest
Reactome:R-HSA-112396
Separation of elongating transcript from template
Reactome:R-HSA-112435
Formation of Elongin BC complex
Reactome:R-HSA-112436
Formation of Elongin complex
Reactome:R-HSA-113411
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
Reactome:R-HSA-113412
Pol II elongation complex moves on the template as transcript elongates
Reactome:R-HSA-113413
TFIIS-mediated recovery of elongation from arrest
Reactome:R-HSA-113414
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
Reactome:R-HSA-113429
Elongating transcript encounters a lesion in the template
Reactome:R-HSA-1234159
Proteasome proteolyzes ub-HIF-alpha
Reactome:R-HSA-1234163
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
Reactome:R-HSA-1234169
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
Reactome:R-HSA-1234172
Nuclear VBC complex ubiquitinylates HIF-alpha
Reactome:R-HSA-1234173
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A
Reactome:R-HSA-1234175
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
Reactome:R-HSA-1234177
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
Reactome:R-HSA-1234183
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
Reactome:R-HSA-180540
Multi-ubiquitination of APOBEC3G
Reactome:R-HSA-180555
Association of APOBEC3G:Vif with the Cul5-SCF complex
Reactome:R-HSA-180603
Proteosome-mediated degradation of APOBEC3G
Reactome:R-HSA-6797606
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
Reactome:R-HSA-6797616
CCNK:CDK12 binds RNA Pol II at DNA repair genes
Reactome:R-HSA-8952039
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
Reactome:R-HSA-8952044
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
Reactome:R-HSA-8952625
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
Reactome:R-HSA-8952626
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex
Reactome:R-HSA-8955241
CAND1 binds cytosolic CRL E3 ubiquitin ligases
Reactome:R-HSA-8955289
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
Reactome:R-HSA-8956040
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
Reactome:R-HSA-8956099
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
Reactome:R-HSA-8956103
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
Reactome:R-HSA-8956106
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
Reactome:R-HSA-9705738
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
Reactome:R-HSA-9755303
26S proteasome degrades HIFalpha
Reactome:R-HSA-9833107
Association of NS1 (1C) with Cul5 and SCF
Reactome:R-HSA-9833155
Ubiquitination of STAT2
Reactome:R-HSA-9954721
NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide
Reactome:R-HSA-9954723
NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide

📄 View Raw YAML

 
id: Q15370
gene_symbol: ELOB
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for ELOB'
alternative_products:
- name: '1'
  id: Q15370-1
- name: '2'
  id: Q15370-2
  sequence_note: VSP_045784
existing_annotations:
- term:
    id: GO:0070449
    label: elongin complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030891
    label: VCB complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000151
    label: ubiquitin ligase complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006368
    label: transcription elongation by RNA polymerase II
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0030891
    label: VCB complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070449
    label: elongin complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10205047
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12004076
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12050673
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12149480
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15601820
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16189514
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18323857
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20211142
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20871634
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21516116
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22190034
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25416956
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27517496
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:30026228
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32296183
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:40205054
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0016567
    label: protein ubiquitination
  evidence_type: IEA
  original_reference_id: GO_REF:0000041
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:40963025
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0000122
    label: negative regulation of transcription by RNA polymerase II
  evidence_type: NAS
  original_reference_id: PMID:28591624
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:31273098
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: NAS
  original_reference_id: PMID:15601820
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: NAS
  original_reference_id: PMID:21822215
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: NAS
  original_reference_id: PMID:22649776
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: NAS
  original_reference_id: PMID:29779948
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: NAS
  original_reference_id: PMID:33398168
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: NAS
  original_reference_id: PMID:34743205
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:1990116
    label: ribosome-associated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:33909987
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:2000104
    label: negative regulation of DNA-templated DNA replication
  evidence_type: NAS
  original_reference_id: PMID:22649776
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:39039081
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:40440427
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031462
    label: Cul2-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:35978186
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031462
    label: Cul2-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:37844242
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140627
    label: ubiquitin-dependent protein catabolic process via the C-end degron rule
      pathway
  evidence_type: IDA
  original_reference_id: PMID:37844242
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:35512830
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:37816714
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:34857742
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:21980433
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:25505247
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:38418882
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:31387940
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:32513959
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:23837592
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:33268465
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0140958
    label: target-directed miRNA degradation
  evidence_type: IMP
  original_reference_id: PMID:33184237
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22510880
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0001222
    label: transcription corepressor binding
  evidence_type: IPI
  original_reference_id: PMID:7660122
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006367
    label: transcription initiation at RNA polymerase II promoter
  evidence_type: IDA
  original_reference_id: PMID:7660122
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0070449
    label: elongin complex
  evidence_type: IDA
  original_reference_id: PMID:7660122
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21119685
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein catabolic
      process
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23401859
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26906416
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234159
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234163
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234173
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234177
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234183
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180540
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180555
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-180603
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952039
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952044
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952625
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8952626
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8955241
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8955289
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956040
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956099
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956103
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-8956106
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9705738
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9755303
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9833107
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9833155
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9954721
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9954723
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112379
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112385
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112392
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112395
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112396
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112435
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-112436
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-113411
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-113412
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-113413
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-113414
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-113429
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234169
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234172
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1234175
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6797606
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-6797616
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IDA
  original_reference_id: PMID:17636018
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031462
    label: Cul2-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:17636018
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0031466
    label: Cul5-RING ubiquitin ligase complex
  evidence_type: IDA
  original_reference_id: PMID:17636018
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15590694
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0006368
    label: transcription elongation by RNA polymerase II
  evidence_type: TAS
  original_reference_id: PMID:7660129
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
- term:
    id: GO:0065003
    label: protein-containing complex assembly
  evidence_type: TAS
  original_reference_id: PMID:7660129
  review:
    summary: 'TODO: Review this GOA annotation'
    action: PENDING
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with GO
    terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to orthologs
    by curator judgment of sequence similarity
  findings: []
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
- id: GO_REF:0000041
  title: Gene Ontology annotation based on UniPathway vocabulary mapping
  findings: []
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location
    vocabulary mapping, accompanied by conservative changes to GO terms applied by
    UniProt
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data to
    orthologs using Ensembl Compara
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning models
  findings: []
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
- id: PMID:10205047
  title: 'Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor
    suppressor function.'
  findings: []
- id: PMID:12004076
  title: 'Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in
    signaling.'
  findings: []
- id: PMID:12050673
  title: Structural basis for the recognition of hydroxyproline in HIF-1 alpha by
    pVHL.
  findings: []
- id: PMID:12149480
  title: Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that
    can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
  findings: []
- id: PMID:15590694
  title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor
    receptor signaling.
  findings: []
- id: PMID:15601820
  title: VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1
    and Cul5-Rbx2 modules of ubiquitin ligases.
  findings: []
- id: PMID:16189514
  title: Towards a proteome-scale map of the human protein-protein interaction network.
  findings: []
- id: PMID:17636018
  title: ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation
    via an oxygen-dependent mechanism.
  findings: []
- id: PMID:18323857
  title: NEDD8 acts as a 'molecular switch' defining the functional selectivity of
    VHL.
  findings: []
- id: PMID:20211142
  title: An atlas of combinatorial transcriptional regulation in mouse and man.
  findings: []
- id: PMID:20871634
  title: Regulation of receptor for activated C kinase 1 protein by the von Hippel-Lindau
    tumor suppressor in IGF-I-induced renal carcinoma cell invasiveness.
  findings: []
- id: PMID:21119685
  title: Notch-induced Asb2 expression promotes protein ubiquitination by forming
    non-canonical E3 ligase complexes.
  findings: []
- id: PMID:21516116
  title: Next-generation sequencing to generate interactome datasets.
  findings: []
- id: PMID:21822215
  title: The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates
    with active NFY promoters.
  findings: []
- id: PMID:21980433
  title: The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
  findings: []
- id: PMID:22190034
  title: Global landscape of HIV-human protein complexes.
  findings: []
- id: PMID:22510880
  title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis
    and tumour formation.
  findings: []
- id: PMID:22649776
  title: The Role of Elongin BC-Containing Ubiquitin Ligases.
  findings: []
- id: PMID:23401859
  title: DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
  findings: []
- id: PMID:23837592
  title: 'Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9),
    ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type
    Cullin-RING E3 ubiquitin ligases.'
  findings: []
- id: PMID:25416956
  title: A proteome-scale map of the human interactome network.
  findings: []
- id: PMID:25505247
  title: 'Biophysical studies on interactions and assembly of full-size E3 ubiquitin
    ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box
    protein 2 (RBX2).'
  findings: []
- id: PMID:26906416
  title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
  findings: []
- id: PMID:27517496
  title: USP9X destabilizes pVHL and promotes cell proliferation.
  findings: []
- id: PMID:28591624
  title: Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
  findings: []
- id: PMID:29779948
  title: The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal
    Degrons.
  findings: []
- id: PMID:30026228
  title: VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell
    renal cell carcinoma.
  findings: []
- id: PMID:31273098
  title: A glycine-specific N-degron pathway mediates the quality control of protein
    N-myristoylation.
  findings: []
- id: PMID:31387940
  title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during
    cellular stress.
  findings: []
- id: PMID:32296183
  title: A reference map of the human binary protein interactome.
  findings: []
- id: PMID:32513959
  title: Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
  findings: []
- id: PMID:33184237
  title: The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
  findings: []
- id: PMID:33268465
  title: The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
  findings: []
- id: PMID:33398168
  title: Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1)
    E3 ligase.
  findings: []
- id: PMID:33909987
  title: Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine
    tailing.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the human
    interactome.
  findings: []
- id: PMID:34743205
  title: CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting
    p14(ARF) degradation.
  findings: []
- id: PMID:34857742
  title: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding
    to phosphorylated ligands.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: PMID:35512830
  title: Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28
    ubiquitylation.
  findings: []
- id: PMID:35978186
  title: Post-translational control of beige fat biogenesis by PRDM16 stabilization.
  findings: []
- id: PMID:37816714
  title: Structure-based design of a phosphotyrosine-masked covalent ligand targeting
    the E3 ligase SOCS2.
  findings: []
- id: PMID:37844242
  title: Molecular basis for C-degron recognition by CRL2(APPBP2) ubiquitin ligase.
  findings: []
- id: PMID:38418882
  title: The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.
  findings: []
- id: PMID:39039081
  title: Molecular insights into degron recognition by CRL5(ASB7) ubiquitin ligase.
  findings: []
- id: PMID:40205054
  title: Multimodal cell maps as a foundation for structural and functional genomics.
  findings: []
- id: PMID:40440427
  title: ASB7 is a negative regulator of H3K9me3 homeostasis.
  findings: []
- id: PMID:40963025
  title: Covariation MS uncovers a protein that controls cysteine catabolism.
  findings: []
- id: PMID:7660122
  title: Inhibition of transcription elongation by the VHL tumor suppressor protein.
  findings: []
- id: PMID:7660129
  title: 'Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase
    II.'
  findings: []
- id: Reactome:R-HSA-112379
  title: Recruitment of elongation factors to form elongation complex
  findings: []
- id: Reactome:R-HSA-112385
  title: Addition of nucleotides leads to transcript elongation
  findings: []
- id: Reactome:R-HSA-112392
  title: Resumption of elongation after recovery from pausing
  findings: []
- id: Reactome:R-HSA-112395
  title: Abortive termination of elongation after arrest
  findings: []
- id: Reactome:R-HSA-112396
  title: Separation of elongating transcript from template
  findings: []
- id: Reactome:R-HSA-112435
  title: Formation of Elongin BC complex
  findings: []
- id: Reactome:R-HSA-112436
  title: Formation of Elongin complex
  findings: []
- id: Reactome:R-HSA-113411
  title: 2-4 nt.backtracking of Pol II complex on the template leading to elongation
    pausing
  findings: []
- id: Reactome:R-HSA-113412
  title: Pol II elongation complex moves on the template as transcript elongates
  findings: []
- id: Reactome:R-HSA-113413
  title: TFIIS-mediated recovery of elongation from arrest
  findings: []
- id: Reactome:R-HSA-113414
  title: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation
    arrest
  findings: []
- id: Reactome:R-HSA-113429
  title: Elongating transcript encounters a lesion in the template
  findings: []
- id: Reactome:R-HSA-1234159
  title: Proteasome proteolyzes ub-HIF-alpha
  findings: []
- id: Reactome:R-HSA-1234163
  title: Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
  findings: []
- id: Reactome:R-HSA-1234169
  title: Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
  findings: []
- id: Reactome:R-HSA-1234172
  title: Nuclear VBC complex ubiquitinylates HIF-alpha
  findings: []
- id: Reactome:R-HSA-1234173
  title: Cytosolic PHD2,3 hydroxylates proline residues on HIF3A
  findings: []
- id: Reactome:R-HSA-1234175
  title: ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus
    to the cytosol
  findings: []
- id: Reactome:R-HSA-1234177
  title: Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
  findings: []
- id: Reactome:R-HSA-1234183
  title: Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
  findings: []
- id: Reactome:R-HSA-180540
  title: Multi-ubiquitination of APOBEC3G
  findings: []
- id: Reactome:R-HSA-180555
  title: Association of APOBEC3G:Vif with the Cul5-SCF complex
  findings: []
- id: Reactome:R-HSA-180603
  title: Proteosome-mediated degradation of APOBEC3G
  findings: []
- id: Reactome:R-HSA-6797606
  title: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
  findings: []
- id: Reactome:R-HSA-6797616
  title: CCNK:CDK12 binds RNA Pol II at DNA repair genes
  findings: []
- id: Reactome:R-HSA-8952039
  title: NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-8952044
  title: AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-8952625
  title: NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-8952626
  title: AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex
  findings: []
- id: Reactome:R-HSA-8955241
  title: CAND1 binds cytosolic CRL E3 ubiquitin ligases
  findings: []
- id: Reactome:R-HSA-8955289
  title: COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
  findings: []
- id: Reactome:R-HSA-8956040
  title: COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
  findings: []
- id: Reactome:R-HSA-8956099
  title: VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
  findings: []
- id: Reactome:R-HSA-8956103
  title: VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
  findings: []
- id: Reactome:R-HSA-8956106
  title: VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
  findings: []
- id: Reactome:R-HSA-9705738
  title: SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
  findings: []
- id: Reactome:R-HSA-9755303
  title: 26S proteasome degrades HIFalpha
  findings: []
- id: Reactome:R-HSA-9833107
  title: Association of NS1 (1C) with Cul5 and SCF
  findings: []
- id: Reactome:R-HSA-9833155
  title: Ubiquitination of STAT2
  findings: []
- id: Reactome:R-HSA-9954721
  title: NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed
    nascent peptide
  findings: []
- id: Reactome:R-HSA-9954723
  title: NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide
  findings: []