GENE PRODUCT DB GENE PRODUCT ID SYMBOL QUALIFIER GO TERM GO NAME GO ASPECT ECO ID GO EVIDENCE CODE REFERENCE WITH/FROM TAXON ID TAXON NAME ASSIGNED BY GENE NAME DATE UniProtKB O94905 ERLIN2 is_active_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000794169|UniProtKB:O75477|UniProtKB:O94905|WB:WBGene00016592 9606 Homo sapiens GO_Central Erlin-2 20170228 UniProtKB O94905 ERLIN2 enables GO:0015485 cholesterol binding molecular_function ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000794169|UniProtKB:O75477 9606 Homo sapiens GO_Central Erlin-2 20170228 UniProtKB O94905 ERLIN2 involved_in GO:0032933 SREBP signaling pathway biological_process ECO:0000318 IBA GO_REF:0000033 PANTHER:PTN000794169|UniProtKB:O75477|UniProtKB:O94905 9606 Homo sapiens GO_Central Erlin-2 20170228 UniProtKB O94905 ERLIN2 located_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000256 IEA GO_REF:0000002 InterPro:IPR033294 9606 Homo sapiens InterPro Erlin-2 20260601 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000501 IEA GO_REF:0000120 ARBA:ARBA00028685|UniProtKB-SubCell:SL-0097 9606 Homo sapiens UniProt Erlin-2 20260601 UniProtKB O94905 ERLIN2 enables GO:0031625 ubiquitin protein ligase binding molecular_function ECO:0000256 IEA GO_REF:0000002 InterPro:IPR033294 9606 Homo sapiens InterPro Erlin-2 20260601 UniProtKB O94905 ERLIN2 involved_in GO:0032933 SREBP signaling pathway biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00087340 9606 Homo sapiens UniProt Erlin-2 20260601 UniProtKB O94905 ERLIN2 part_of GO:0032991 protein-containing complex cellular_component ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00028902 9606 Homo sapiens UniProt Erlin-2 20260601 UniProtKB O94905 ERLIN2 involved_in GO:0036503 ERAD pathway biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00029018 9606 Homo sapiens UniProt Erlin-2 20260601 UniProtKB O94905 ERLIN2 involved_in GO:0045541 negative regulation of cholesterol biosynthetic process biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00085017 9606 Homo sapiens UniProt Erlin-2 20260601 UniProtKB O94905 ERLIN2 involved_in GO:0045717 negative regulation of fatty acid biosynthetic process biological_process ECO:0000256 IEA GO_REF:0000117 ARBA:ARBA00084177 9606 Homo sapiens UniProt Erlin-2 20260601 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21343306 UniProtKB:O75477 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21343306 UniProtKB:P00347 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21343306 UniProtKB:Q86TM6 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21343306 UniProtKB:Q9BVT8 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:21343306 UniProtKB:Q9UKV5 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:22119785 UniProtKB:O75477 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:22119785 UniProtKB:Q86TM6 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:22119785 UniProtKB:Q9UKV5 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:30021884 UniProtKB:O75477 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:O75477 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:33961781 UniProtKB:Q9BVT8 9606 Homo sapiens IntAct Erlin-2 20260530 UniProtKB O94905 ERLIN2 located_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000314 IDA GO_REF:0000052 9606 Homo sapiens HPA Erlin-2 20251115 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000314 IDA PMID:19240031 9606 Homo sapiens ComplexPortal Erlin-2 20240823 UniProtKB O94905 ERLIN2 involved_in GO:0036503 ERAD pathway biological_process ECO:0000314 IDA PMID:19240031 9606 Homo sapiens ComplexPortal Erlin-2 20240823 UniProtKB O94905 ERLIN2 located_in GO:0045121 membrane raft cellular_component ECO:0005547 NAS PMID:34572057 9606 Homo sapiens ComplexPortal Erlin-2 20240823 UniProtKB O94905 ERLIN2 involved_in GO:0045540 regulation of cholesterol biosynthetic process biological_process ECO:0000314 IDA PMID:24217618 9606 Homo sapiens ComplexPortal Erlin-2 20240823 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-1839094 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-1839098 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-1839100 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655240 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655263 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655266 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655269 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655278 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655290 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-5655326 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8853322 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 located_in GO:0005886 plasma membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8853325 9606 Homo sapiens Reactome Erlin-2 20230402 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:30352685 UniProtKB:Q5BJD5 9606 Homo sapiens UniProt Erlin-2 20200102 UniProtKB O94905 ERLIN2 part_of GO:0032991 protein-containing complex cellular_component ECO:0000314 IDA PMID:18468998 9606 Homo sapiens MGI Erlin-2 20180219 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866542 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866546 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866551 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866854 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866856 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-8866857 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9931264 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9931298 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000304 TAS Reactome:R-HSA-9931313 9606 Homo sapiens Reactome Erlin-2 20160519 UniProtKB O94905 ERLIN2 enables GO:0031625 ubiquitin protein ligase binding molecular_function ECO:0000353 IPI PMID:24019521 UniProtKB:Q96GF1 9606 Homo sapiens ParkinsonsUK-UCL Erlin-2 20150521 UniProtKB O94905 ERLIN2 enables GO:0031625 ubiquitin protein ligase binding molecular_function ECO:0000353 IPI PMID:24019521 UniProtKB:Q99942 9606 Homo sapiens ParkinsonsUK-UCL Erlin-2 20150521 UniProtKB O94905 ERLIN2 involved_in GO:0032933 SREBP signaling pathway biological_process ECO:0000315 IMP PMID:24217618 9606 Homo sapiens UniProt Erlin-2 20150504 UniProtKB O94905 ERLIN2 involved_in GO:0045541 negative regulation of cholesterol biosynthetic process biological_process ECO:0000315 IMP PMID:24217618 9606 Homo sapiens UniProt Erlin-2 20150504 UniProtKB O94905 ERLIN2 involved_in GO:0045717 negative regulation of fatty acid biosynthetic process biological_process ECO:0000315 IMP PMID:24217618 9606 Homo sapiens UniProt Erlin-2 20150504 UniProtKB O94905 ERLIN2 located_in GO:0045121 membrane raft cellular_component ECO:0000314 IDA PMID:25204797 9606 Homo sapiens UniProt Erlin-2 20150402 UniProtKB O94905 ERLIN2 located_in GO:0005783 endoplasmic reticulum cellular_component ECO:0000314 IDA GO_REF:0000054 9606 Homo sapiens LIFEdb Erlin-2 20100607 UniProtKB O94905 ERLIN2 enables GO:0005515 protein binding molecular_function ECO:0000353 IPI PMID:19240031 UniProtKB:O75477 9606 Homo sapiens UniProt Erlin-2 20090909 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000314 IDA PMID:19240031 9606 Homo sapiens UniProt Erlin-2 20090909 UniProtKB O94905 ERLIN2 involved_in GO:0036503 ERAD pathway biological_process ECO:0000314 IDA PMID:19240031 9606 Homo sapiens UniProt Erlin-2 20090909 UniProtKB O94905 ERLIN2 located_in GO:0005789 endoplasmic reticulum membrane cellular_component ECO:0000314 IDA PMID:16835267 9606 Homo sapiens UniProt Erlin-2 20070426