FBXL7 (F-box/LRR-repeat protein 7) is the substrate-recognition (F-box) subunit of an SCF (SKP1-CUL1-RBX1-F-box) cullin-RING E3 ubiquitin ligase that controls mitotic progression and apoptosis by directing the ubiquitination and proteasomal degradation of mitotic regulators. Within the SCF(FBXL7) complex, FBXL7 binds SKP1 via its F-box domain and uses its leucine-rich repeats to recruit substrates, so that CUL1-RBX1 drives their polyubiquitination. Its best-characterized substrates are the mitotic kinase Aurora A (AURKA), which FBXL7 colocalizes with and targets for centrosomal degradation during mitosis to promote mitotic arrest, and the inhibitor-of-apoptosis protein survivin/BIRC5 (recognized via survivin Glu126; ubiquitinated at Lys90/Lys91), whose FBXL7-mediated degradation regulates mitochondrial function and promotes apoptosis. FBXL7 (a 491-residue protein with an N-terminal F-box motif and roughly eleven C-terminal leucine-rich repeats) additionally targets active c-SRC (after Ser104 phosphorylation) and the EMT transcription factor SNAI1/Snail1 for degradation, acting as a metastasis suppressor that restrains SRC- and Snail1-driven epithelial-mesenchymal transition and invasion, and it ubiquitinates the glycolytic enzyme PFKFB4, coupling FBXL7 to metabolic reprogramming. FBXL7 localizes to the centrosome during spindle formation. FBXL7 is itself a proapoptotic factor whose cellular abundance is controlled by the related F-box protein FBXL18, which ubiquitinates FBXL7 (at Lys109) for proteasomal degradation, and its expression is repressed transcriptionally (e.g. by hypoxia-induced EZH2 and by promoter hypermethylation in cancer). Through these activities FBXL7 contributes to the G2/M transition, spindle dynamics, apoptotic signaling, EMT/metastasis suppression, and metabolic control, and is implicated in cancer progression and drug resistance.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:1990756 ubiquitin-like ligase-substrate adaptor activity | IDA PMID:25778398 The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial... | NEW | Summary: Proposed core molecular function. As the F-box/LRR substrate-recognition subunit of SCF(FBXL7), FBXL7 selects substrates (AURKA, survivin/BIRC5) for SCF-dependent polyubiquitination. This more informative MF term is not in the GOA, which lacks any explicit MF annotation for FBXL7. Reason: Captures the precise molecular function of FBXL7 as an SCF substrate-recognition adaptor, more informative than the bare protein binding annotations and absent from the existing GOA. Supporting Evidence: PMID:25778398 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin by interacting with Glu-126 within its carboxyl-terminal α helix |
| GO:0005813 centrosome | IEA GO_REF:0000120 | ACCEPT | Summary: Combined automated electronic assignment of centrosome localization, where FBXL7 acts during spindle formation. Core localization for its mitotic role. Reason: Core localization; FBXL7 localizes to the centrosome during spindle formation, consistent with its mitotic substrate-targeting role. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | KEEP AS NON CORE | Summary: Binary interactome reference map interactions. Bare protein binding is uninformative. Reason: High-throughput interactome; bare protein binding is uninformative per curation guidelines. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Q9UJT9; Q92609: TBC1D5; NbExp=3; IntAct=EBI-914660, EBI-742381 |
| GO:0000086 G2/M transition of mitotic cell cycle | IEA GO_REF:0000107 | ACCEPT | Summary: Ortholog-based electronic assignment of involvement in the G2/M transition, consistent with FBXL7-driven AURKA degradation and mitotic arrest. Reason: Core biological process; FBXL7 regulates mitotic progression (mitotic arrest via AURKA degradation). Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest |
| GO:0000209 protein polyubiquitination | IEA GO_REF:0000120 | ACCEPT | Summary: Combined automated electronic assignment of protein polyubiquitination, the specific modification FBXL7 directs onto its substrates. Reason: Correct; FBXL7 mediates substrate polyubiquitination, supported by IDA/IMP evidence (survivin). Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 |
| GO:0000278 mitotic cell cycle | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ortholog-based electronic assignment of involvement in the mitotic cell cycle, consistent with FBXL7's role in mitotic regulation. Reason: Correct but generic relative to the specific G2/M transition and SCF-dependent degradation annotations. Supporting Evidence: PMID:25778398 Fbxl7, a component of the Skp1·Cul1·F-box protein type ubiquitin E3 ligase, regulates mitotic cell cycle progression |
| GO:0016567 protein ubiquitination | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Combined automated electronic assignment of protein ubiquitination, a parent of the specific SCF-dependent polyubiquitination FBXL7 mediates. Reason: Correct but generic; the specific SCF-dependent catabolic / polyubiquitination annotations better capture the role. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt PATHWAY: Protein modification; protein ubiquitination. |
| GO:0019005 SCF ubiquitin ligase complex | IEA GO_REF:0000120 | ACCEPT | Summary: Combined automated electronic assignment of SCF complex membership, the core assembly context for FBXL7. Reason: Core cellular component; redundant with IDA/ISS evidence. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7 |
| GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IEA GO_REF:0000120 | ACCEPT | Summary: Combined automated electronic assignment of SCF-dependent proteasomal degradation, the core biological process of SCF(FBXL7). Reason: Core biological process; redundant with the experimental IDA/IMP evidence (survivin/AURKA degradation). Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 |
| GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | NAS PMID:33234069 The FBXL family of F-box proteins: variations on a theme. | ACCEPT | Summary: Author-statement (FBXL family review) assignment of the core SCF-dependent proteasomal degradation process. Reason: Core biological process; consistent with the experimental substrate-degradation evidence. Supporting Evidence: PMID:25778398 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin |
| GO:0042981 regulation of apoptotic process | NAS PMID:25654763 F-box protein Fbxl18 mediates polyubiquitylation and proteas... | ACCEPT | Summary: Author-statement (ComplexPortal) assignment of regulation of apoptosis; FBXL7 is a proapoptotic factor and its degradation of survivin/BIRC5 promotes apoptosis. Reason: Supported biological process; FBXL7 is proapoptotic and regulates apoptosis via degradation of the IAP survivin/BIRC5. Supporting Evidence: PMID:25654763 Fbxl18 regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein Fbxl7 |
| GO:0000209 protein polyubiquitination | IMP PMID:28218735 Aurora kinase A regulates Survivin stability through targeti... | ACCEPT | Summary: Mutant-phenotype evidence that FBXL7 mediates polyubiquitination of BIRC5/survivin. Core activity. Reason: Directly supported substrate polyubiquitination (survivin/BIRC5); consistent with FBXL7's SCF substrate-receptor function. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt this interaction allows BIRC5 to be polyubiquitinated by the SCF(FBXL7) E3 ubiquitin-protein ligase complex |
| GO:0005515 protein binding | IPI PMID:28218735 Aurora kinase A regulates Survivin stability through targeti... | KEEP AS NON CORE | Summary: Interaction with BIRC5/survivin (a FBXL7 substrate). Bare protein binding is uninformative. Reason: Records the functionally important FBXL7-BIRC5 substrate interaction but bare protein binding is uninformative. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Interacts with BIRC5; this interaction allows BIRC5 to be polyubiquitinated by the SCF(FBXL7) |
| GO:0019005 SCF ubiquitin ligase complex | IDA PMID:25778398 The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial... | ACCEPT | Summary: Direct evidence that FBXL7 is a component of the SCF (SKP1-CUL1-F-box) E3 ligase complex. Core cellular component. Reason: Core cellular component; FBXL7 is the F-box substrate receptor of the SCF(FBXL7) complex. Supporting Evidence: PMID:25778398 Fbxl7, a component of the Skp1·Cul1·F-box protein type ubiquitin E3 ligase, regulates mitotic cell cycle progression |
| GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA PMID:25778398 The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial... | ACCEPT | Summary: Direct evidence that SCF(FBXL7) drives proteasomal degradation of survivin/BIRC5. Core biological process. Reason: Core biological process directly demonstrated; FBXL7 targets survivin for SCF-dependent proteasomal degradation. Supporting Evidence: PMID:25778398 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin |
| GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IMP PMID:28218735 Aurora kinase A regulates Survivin stability through targeti... | ACCEPT | Summary: Mutant-phenotype evidence linking FBXL7 to SCF-dependent degradation of survivin in the AURKA/gastric-cancer study. Core biological process. Reason: Core biological process; FBXL7 mediates proteasomal degradation of survivin/BIRC5. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 |
| GO:0000209 protein polyubiquitination | IDA PMID:25778398 The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial... | ACCEPT | Summary: Direct evidence that FBXL7 polyubiquitinates survivin (at Lys90/Lys91). Core activity. Reason: Directly demonstrated substrate polyubiquitination of survivin/BIRC5. Supporting Evidence: PMID:25778398 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin |
| GO:0005515 protein binding | IPI PMID:25778398 The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial... | KEEP AS NON CORE | Summary: Interaction with survivin (via Glu-126 in its C-terminal helix). Bare protein binding is uninformative. Reason: Records the functionally important FBXL7-survivin substrate interaction but bare protein binding is uninformative. Supporting Evidence: PMID:25778398 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin by interacting with Glu-126 within its carboxyl-terminal α helix |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854051 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (SCF-FBXL18 ubiquitinates FBXL7). Consistent with the cytoplasmic site of action. Reason: Correct cytoplasmic compartment; the functionally salient localization is the centrosome during spindle formation. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854071 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (proteasome-mediated degradation of PolyUb-FBXL7). Consistent with the cytoplasmic site of action. Reason: Correct cytoplasmic compartment; the functionally salient localization is the centrosome. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8853496 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (SCF:FBXL7 binds AURKA). Consistent with the cytoplasmic site of action. Reason: Correct cytoplasmic compartment; the functionally salient localization is the centrosome. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854041 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (SCF-FBXL7 ubiquitinates AURKA). Consistent with the cytoplasmic site of action. Reason: Correct cytoplasmic compartment; the functionally salient localization is the centrosome. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854044 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (proteasome degrades AURKA ubiquitinated by SCF-FBXL7). Consistent with the cytoplasmic site of action. Reason: Correct cytoplasmic compartment; the functionally salient localization is the centrosome. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854052 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (formation of the SCF-FBXL7 complex). Consistent with the cytoplasmic site of action. Reason: Correct cytoplasmic compartment; the functionally salient localization is the centrosome. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7 |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952618 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (neddylation of CRL1). Generic CRL-pathway localization. Reason: Correct cytoplasmic compartment but from generic CRL neddylation-pathway context; the functionally salient localization is the centrosome. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8952620 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (NEDD8:UBE2M binds CRL1). Generic CRL-pathway localization. Reason: Correct cytoplasmic compartment but from generic CRL-pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8955241 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (CAND1 binds cytosolic CRL). Generic CRL-pathway localization. Reason: Correct cytoplasmic compartment but from generic CRL-regulation pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8955289 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (COMMDs displace CAND1). Generic CRL-pathway localization. Reason: Correct cytoplasmic compartment but from generic CRL-regulation pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8956040 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (COP9 signalosome deneddylates CRL). Generic CRL-pathway localization. Reason: Correct cytoplasmic compartment but from generic CRL-regulation pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8956200 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (DCUN1D3 binds CRL1). Generic CRL-pathway localization. Reason: Correct cytoplasmic compartment but from generic CRL-regulation pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983140 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (transfer of Ub from E2 to substrate). Generic ubiquitination-pathway localization. Reason: Correct cytoplasmic compartment but from generic ubiquitination-pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983147 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (release of E3 from polyubiquitinated substrate). Generic ubiquitination-pathway localization. Reason: Correct cytoplasmic compartment but from generic ubiquitination-pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983156 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (polyubiquitination of substrate). Generic ubiquitination-pathway localization. Reason: Correct cytoplasmic compartment but from generic ubiquitination-pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983157 | KEEP AS NON CORE | Summary: Reactome curation of cytosolic localization (interaction of E3 with substrate and E2-Ub). Generic ubiquitination-pathway localization. Reason: Correct cytoplasmic compartment but from generic ubiquitination-pathway context; redundant. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
| GO:0000086 G2/M transition of mitotic cell cycle | ISS GO_REF:0000024 | ACCEPT | Summary: Sequence-similarity assignment of involvement in the G2/M transition, consistent with FBXL7-driven AURKA degradation. Reason: Core biological process; FBXL7 regulates the mitotic G2/M transition. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest |
| GO:0000278 mitotic cell cycle | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Sequence-similarity assignment of involvement in the mitotic cell cycle. Reason: Correct but generic relative to the specific G2/M transition annotation. Supporting Evidence: PMID:25778398 Fbxl7, a component of the Skp1·Cul1·F-box protein type ubiquitin E3 ligase, regulates mitotic cell cycle progression |
| GO:0005813 centrosome | ISS GO_REF:0000024 | ACCEPT | Summary: Sequence-similarity assignment of centrosome localization, where FBXL7 acts during spindle formation. Core localization. Reason: Core localization; FBXL7 localizes to the centrosome during spindle formation. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Localizes to the centrosome during spindle formation. |
| GO:0016567 protein ubiquitination | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Sequence-similarity assignment of protein ubiquitination, a parent of the specific SCF-dependent polyubiquitination FBXL7 mediates. Reason: Correct but generic; the specific polyubiquitination/SCF-dependent catabolic annotations better capture the role. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt PATHWAY: Protein modification; protein ubiquitination. |
| GO:0019005 SCF ubiquitin ligase complex | ISS GO_REF:0000024 | ACCEPT | Summary: Sequence-similarity assignment of SCF complex membership, the core assembly context for FBXL7. Reason: Core cellular component; redundant with IDA/IEA evidence. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7 |
| GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | ISS GO_REF:0000024 | ACCEPT | Summary: Sequence-similarity assignment of SCF-dependent proteasomal degradation, the core biological process of SCF(FBXL7). Reason: Core biological process; redundant with the experimental IDA/IMP evidence. Supporting Evidence: PMID:25778398 Fbxl7 mediates polyubiquitylation and proteasomal degradation of survivin |
| GO:0000151 ubiquitin ligase complex | NAS PMID:10531035 Identification of a family of human F-box proteins. | KEEP AS NON CORE | Summary: Author-statement assignment (original F-box family paper) of being part of a ubiquitin ligase complex. A generic parent of the specific SCF complex. Reason: Correct but generic; subsumed by the specific SCF ubiquitin ligase complex annotation. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) |
| GO:0006511 ubiquitin-dependent protein catabolic process | NAS PMID:10531035 Identification of a family of human F-box proteins. | KEEP AS NON CORE | Summary: Author-statement assignment of ubiquitin-dependent protein catabolism, a parent of the specific SCF-dependent proteasomal degradation FBXL7 mediates. Reason: Correct but generic; the specific GO:0031146 (SCF-dependent proteasomal catabolic process) better captures the role. Supporting Evidence: file:human/FBXL7/FBXL7-uniprot.txt regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 |
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Download this section (compressed HTML)Q: Are the two best-described FBXL7 substrates (AURKA and survivin/BIRC5) targeted by the same FBXL7 pool and cell-cycle window, or do distinct localizations (centrosomal versus cytosolic) and timing govern each substrate?
Q: How does the FBXL18-FBXL7 regulatory axis controlling FBXL7 abundance influence the balance between mitotic progression and apoptosis, and is it dysregulated in cancers with AURKA/survivin overexpression?
Q: FBXL7 is reported to degrade a broad substrate set (AURKA, survivin/BIRC5, active c-SRC, SNAI1/Snail1, PFKFB4) and behaves as a tumor suppressor or context-dependent oncogenic factor across tissues; which of these substrate axes is dominant in a given cell type, and what determines whether FBXL7 loss is pro- or anti-tumorigenic?
Experiment: Reconstitute SCF(FBXL7)-mediated ubiquitination of AURKA and of survivin/BIRC5 in vitro with purified SKP1, CUL1, RBX1, an E2, and wild-type versus substrate-binding-mutant FBXL7 to map substrate lysine sites and confirm direct, SCF-dependent polyubiquitination.
Experiment: Perform synchronized cell-cycle proteomics and live-cell imaging in FBXL7-knockout versus wild-type cells to quantify AURKA and survivin turnover across mitosis, define FBXL7's centrosomal localization dynamics, and test the apoptotic consequences of substrate stabilization.
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