ID   FBX15_HUMAN             Reviewed;         510 AA.
AC   Q8NCQ5; B3KST3;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   10-JUN-2026, entry version 157.
DE   RecName: Full=F-box only protein 15;
GN   Name=FBXO15; Synonyms=FBX15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8NCQ5; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-6660598, EBI-1055254;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8NCQ5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NCQ5-2; Sequence=VSP_043033;
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DR   EMBL; AK094215; BAG52845.1; -; mRNA.
DR   EMBL; CH471117; EAW66537.1; -; Genomic_DNA.
DR   EMBL; BC029579; AAH29579.1; -; mRNA.
DR   CCDS; CCDS45884.1; -. [Q8NCQ5-1]
DR   RefSeq; NP_001136430.1; NM_001142958.2. [Q8NCQ5-1]
DR   RefSeq; NP_689889.1; NM_152676.3. [Q8NCQ5-2]
DR   RefSeq; XP_016881093.1; XM_017025604.3. [Q8NCQ5-2]
DR   RefSeq; XP_047293297.1; XM_047437341.1. [Q8NCQ5-2]
DR   RefSeq; XP_047293298.1; XM_047437342.1. [Q8NCQ5-2]
DR   RefSeq; XP_054174242.1; XM_054318267.1. [Q8NCQ5-2]
DR   RefSeq; XP_054174243.1; XM_054318268.1. [Q8NCQ5-2]
DR   RefSeq; XP_054174244.1; XM_054318269.1. [Q8NCQ5-2]
DR   AlphaFoldDB; Q8NCQ5; -.
DR   BioGRID; 128386; 12.
DR   ComplexPortal; CPX-7925; SCF E3 ubiquitin ligase complex, FBXO15 variant.
DR   FunCoup; Q8NCQ5; 91.
DR   IntAct; Q8NCQ5; 7.
DR   NDEx; IQUERY-CP-FBXO15; 1 NDEx IQuery Curated Pathway.
DR   STRING; 9606.ENSP00000393154; -.
DR   GlyGen; Q8NCQ5; 1 site.
DR   iPTMnet; Q8NCQ5; -.
DR   PhosphoSitePlus; Q8NCQ5; -.
DR   BioMuta; FBXO15; -.
DR   DMDM; 384872371; -.
DR   jPOST; Q8NCQ5; -.
DR   MassIVE; Q8NCQ5; -.
DR   PaxDb; 9606-ENSP00000393154; -.
DR   PeptideAtlas; Q8NCQ5; -.
DR   ProteomicsDB; 72921; -. [Q8NCQ5-1]
DR   ProteomicsDB; 72922; -. [Q8NCQ5-2]
DR   Antibodypedia; 42215; 193 antibodies from 25 providers.
DR   DNASU; 201456; -.
DR   Ensembl; ENST00000419743.7; ENSP00000393154.2; ENSG00000141665.14. [Q8NCQ5-1]
DR   GeneID; 201456; -.
DR   KEGG; hsa:201456; -.
DR   MANE-Select; ENST00000419743.7; ENSP00000393154.2; NM_001142958.2; NP_001136430.1.
DR   UCSC; uc002llf.3; human. [Q8NCQ5-1]
DR   AGR; HGNC:13617; -.
DR   ClinPGx; PA134894755; -.
DR   CTD; 201456; -.
DR   DisGeNET; 201456; -.
DR   GeneCards; FBXO15; -.
DR   HGNC; HGNC:13617; FBXO15.
DR   HPA; ENSG00000141665; Tissue enhanced (fallopian tube, testis).
DR   MIM; 609093; gene.
DR   OpenTargets; ENSG00000141665; -.
DR   VEuPathDB; HostDB:ENSG00000141665; -.
DR   eggNOG; ENOG502QPX2; Eukaryota.
DR   GeneTree; ENSGT00390000017498; -.
DR   HOGENOM; CLU_047012_0_0_1; -.
DR   InParanoid; Q8NCQ5; -.
DR   OMA; YIMEHID; -.
DR   OrthoDB; 3219396at2759; -.
DR   PAN-GO; Q8NCQ5; 1 GO annotation based on evolutionary models.
DR   PhylomeDB; Q8NCQ5; -.
DR   PathwayCommons; Q8NCQ5; -.
DR   Reactome; R-HSA-8951664; Neddylation.
DR   Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   SignaLink; Q8NCQ5; -.
DR   SIGNOR; Q8NCQ5; -.
DR   Agora; ENSG00000141665; -.
DR   BioGRID-ORCS; 201456; 5 hits in 1184 CRISPR screens.
DR   ChiTaRS; FBXO15; human.
DR   GenomeRNAi; 201456; -.
DR   Pharos; Q8NCQ5; Tbio.
DR   PRO; PR:Q8NCQ5; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q8NCQ5; protein.
DR   Bgee; ENSG00000141665; Expressed in bronchial epithelial cell and 144 other cell types or tissues.
DR   ExpressionAtlas; Q8NCQ5; baseline and differential.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; NAS:ComplexPortal.
DR   CDD; cd22093; F-box_FBXO15; 1.
DR   FunFam; 1.20.1280.50:FF:000061; F-box only protein 15; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   PANTHER; PTHR46731; F-BOX ONLY PROTEIN 15; 1.
DR   PANTHER; PTHR46731:SF1; F-BOX ONLY PROTEIN 15; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Proteomics identification; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..510
FT                   /note="F-box only protein 15"
FT                   /id="PRO_0000119893"
FT   DOMAIN          77..117
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   VAR_SEQ         1..76
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_043033"
FT   VARIANT         496
FT                   /note="Y -> H (in dbSNP:rs35815390)"
FT                   /id="VAR_049040"
SQ   SEQUENCE   510 AA;  57258 MW;  99760CBB50B9DC8E CRC64;
     MATGRGRILQ QHWLGLQTLR GPSRGGGAAR GRARAFGCRK GPGVKLSAGS AALRCHAGGG
     QHWESSFSCC SGFLDGMPSE ILLKIFSYLD AVSLLCTGCV SRRFYHLAND NFIWIGIYST
     AFSPARSNWK FNSVEKIAMS MSFLSVQDKE AGYWKKEYIT KQIASVKAAL ADILKPVNPY
     TGLPVKTKEA LRIFGLGWAI ILKEKGGKEY IMEHVDLSIN DTSVTVIWYG KKWPCLASLS
     TLDLCGMTPV FTDWYKTPTK HRLRWHSLIA KYNLSHLTIS TMIGCDRLIR IFCLHPGLLV
     GVWKKEEELA FVMANLHFHH LVERSTLGSA TIPYELPPHS PFLDDSPEYG LHGYQLHVDL
     HSGGVFYLCG TFRNLFTKRG NIENGHVKLI VIHLKNNREH LPLIGKVGLS WKTDIFDGCI
     KSCSMMDVTL LDEHGKPFWC FSSPVCLRSP ATPSDSSSFL GQTYNVDYVD AEGRVHVELV
     WIRETEEYLI VNLVLYLSIA KINHWFGTEY
//