ID   FBX36_HUMAN             Reviewed;         188 AA.
AC   Q8NEA4; B3KVQ6; Q53TE6; Q8WWD4;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   10-JUN-2026, entry version 152.
DE   RecName: Full=F-box only protein 36;
GN   Name=FBXO36; Synonyms=FBX36;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Amygdala;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PHE-86.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8NEA4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NEA4-3; Sequence=VSP_054336;
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DR   EMBL; AK123085; BAG53868.1; -; mRNA.
DR   EMBL; AK289655; BAF82344.1; -; mRNA.
DR   EMBL; AC009973; AAY14756.1; -; Genomic_DNA.
DR   EMBL; CH471063; EAW70909.1; -; Genomic_DNA.
DR   EMBL; CH471063; EAW70912.1; -; Genomic_DNA.
DR   EMBL; BC033935; AAH33935.1; -; mRNA.
DR   CCDS; CCDS2472.1; -. [Q8NEA4-1]
DR   RefSeq; NP_777559.3; NM_174899.4. [Q8NEA4-1]
DR   AlphaFoldDB; Q8NEA4; -.
DR   SMR; Q8NEA4; -.
DR   BioGRID; 126262; 3.
DR   ComplexPortal; CPX-7976; SCF E3 ubiquitin ligase complex, FBXO36 variant.
DR   FunCoup; Q8NEA4; 162.
DR   IntAct; Q8NEA4; 1.
DR   STRING; 9606.ENSP00000283946; -.
DR   PhosphoSitePlus; Q8NEA4; -.
DR   BioMuta; FBXO36; -.
DR   DMDM; 212288605; -.
DR   MassIVE; Q8NEA4; -.
DR   PaxDb; 9606-ENSP00000283946; -.
DR   PeptideAtlas; Q8NEA4; -.
DR   ProteomicsDB; 3763; -.
DR   ProteomicsDB; 73138; -. [Q8NEA4-1]
DR   Antibodypedia; 34398; 114 antibodies from 20 providers.
DR   DNASU; 130888; -.
DR   Ensembl; ENST00000283946.8; ENSP00000283946.3; ENSG00000153832.13. [Q8NEA4-1]
DR   Ensembl; ENST00000373652.7; ENSP00000362756.3; ENSG00000153832.13. [Q8NEA4-3]
DR   GeneID; 130888; -.
DR   KEGG; hsa:130888; -.
DR   MANE-Select; ENST00000283946.8; ENSP00000283946.3; NM_174899.5; NP_777559.3.
DR   UCSC; uc002vqa.4; human. [Q8NEA4-1]
DR   AGR; HGNC:27020; -.
DR   ClinPGx; PA134918778; -.
DR   CTD; 130888; -.
DR   DisGeNET; 130888; -.
DR   GeneCards; FBXO36; -.
DR   HGNC; HGNC:27020; FBXO36.
DR   HPA; ENSG00000153832; Low tissue specificity.
DR   MIM; 609105; gene.
DR   OpenTargets; ENSG00000153832; -.
DR   VEuPathDB; HostDB:ENSG00000153832; -.
DR   eggNOG; KOG1777; Eukaryota.
DR   GeneTree; ENSGT00390000001015; -.
DR   InParanoid; Q8NEA4; -.
DR   OMA; CNSDELW; -.
DR   OrthoDB; 3219396at2759; -.
DR   PAN-GO; Q8NEA4; 0 GO annotations based on evolutionary models.
DR   PhylomeDB; Q8NEA4; -.
DR   PathwayCommons; Q8NEA4; -.
DR   Agora; ENSG00000153832; -.
DR   BioGRID-ORCS; 130888; 12 hits in 1185 CRISPR screens.
DR   ChiTaRS; FBXO36; human.
DR   GenomeRNAi; 130888; -.
DR   Pharos; Q8NEA4; Tdark.
DR   PRO; PR:Q8NEA4; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8NEA4; protein.
DR   Bgee; ENSG00000153832; Expressed in sperm and 105 other cell types or tissues.
DR   ExpressionAtlas; Q8NEA4; baseline and differential.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; NAS:ComplexPortal.
DR   CDD; cd22106; F-box_FBXO36; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR052301; SCF_F-box/WD-repeat.
DR   PANTHER; PTHR14381; DACTYLIN; 1.
DR   PANTHER; PTHR14381:SF1; F-BOX_WD REPEAT-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Proteomics identification; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..188
FT                   /note="F-box only protein 36"
FT                   /id="PRO_0000119928"
FT   DOMAIN          91..137
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   VAR_SEQ         1..32
FT                   /note="MASWLPETLFETVGQGPPPSKDYYQLLVTRSQ -> M (in isoform
FT                   2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_054336"
FT   VARIANT         86
FT                   /note="L -> F (in dbSNP:rs1035834)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_045626"
SQ   SEQUENCE   188 AA;  22105 MW;  3DBC55B437EB2A39 CRC64;
     MASWLPETLF ETVGQGPPPS KDYYQLLVTR SQVIFRWWKI SLRSEYRSTK PGEAKETHED
     FLENSHLQGQ TALIFGARIL DYVINLCKGK FDFLERLSDD LLLTIISYLD LEDIARLCQT
     SHRFAKLCMS DKLWEQIVQS TCDTITPDVR ALAEDTGWRQ LFFTNKLQLQ RQLRKRKQKY
     GNLREKQP
//