ID   FBX39_HUMAN             Reviewed;         442 AA.
AC   Q8N4B4;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   28-JAN-2026, entry version 149.
DE   RecName: Full=F-box only protein 39;
GN   Name=FBXO39; Synonyms=FBX39;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q8N4B4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12383478, EBI-16439278;
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DR   EMBL; BC034782; AAH34782.1; -; mRNA.
DR   CCDS; CCDS11082.1; -.
DR   RefSeq; NP_694962.1; NM_153230.3.
DR   AlphaFoldDB; Q8N4B4; -.
DR   SMR; Q8N4B4; -.
DR   BioGRID; 127823; 4.
DR   ComplexPortal; CPX-7979; SCF E3 ubiquitin ligase complex, FBXO39 variant.
DR   FunCoup; Q8N4B4; 15.
DR   IntAct; Q8N4B4; 1.
DR   STRING; 9606.ENSP00000321386; -.
DR   iPTMnet; Q8N4B4; -.
DR   PhosphoSitePlus; Q8N4B4; -.
DR   BioMuta; FBXO39; -.
DR   DMDM; 51701431; -.
DR   MassIVE; Q8N4B4; -.
DR   PaxDb; 9606-ENSP00000321386; -.
DR   ProteomicsDB; 71904; -.
DR   Antibodypedia; 53192; 91 antibodies from 14 providers.
DR   DNASU; 162517; -.
DR   Ensembl; ENST00000321535.5; ENSP00000321386.4; ENSG00000177294.7.
DR   GeneID; 162517; -.
DR   KEGG; hsa:162517; -.
DR   MANE-Select; ENST00000321535.5; ENSP00000321386.4; NM_153230.3; NP_694962.1.
DR   UCSC; uc010vtg.3; human.
DR   AGR; HGNC:28565; -.
DR   ClinPGx; PA134889729; -.
DR   CTD; 162517; -.
DR   DisGeNET; 162517; -.
DR   GeneCards; FBXO39; -.
DR   HGNC; HGNC:28565; FBXO39.
DR   HPA; ENSG00000177294; Tissue enriched (testis).
DR   MIM; 609106; gene.
DR   OpenTargets; ENSG00000177294; -.
DR   VEuPathDB; HostDB:ENSG00000177294; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   GeneTree; ENSGT00510000048837; -.
DR   HOGENOM; CLU_050223_0_0_1; -.
DR   InParanoid; Q8N4B4; -.
DR   OMA; MATFHNL; -.
DR   OrthoDB; 61560at2759; -.
DR   PAN-GO; Q8N4B4; 2 GO annotations based on evolutionary models.
DR   PhylomeDB; Q8N4B4; -.
DR   PathwayCommons; Q8N4B4; -.
DR   SignaLink; Q8N4B4; -.
DR   Agora; ENSG00000177294; -.
DR   BioGRID-ORCS; 162517; 8 hits in 1187 CRISPR screens.
DR   GenomeRNAi; 162517; -.
DR   Pharos; Q8N4B4; Tbio.
DR   PRO; PR:Q8N4B4; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q8N4B4; protein.
DR   Bgee; ENSG00000177294; Expressed in right testis and 96 other cell types or tissues.
DR   ExpressionAtlas; Q8N4B4; baseline and differential.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd22108; F-box_FBXO39; 1.
DR   FunFam; 1.20.1280.50:FF:000027; F-box only protein 39; 1.
DR   FunFam; 3.80.10.10:FF:000237; F-box only protein 39; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR045048; FBXO31/39.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR10706; F-BOX FAMILY PROTEIN; 1.
DR   PANTHER; PTHR10706:SF160; F-BOX ONLY PROTEIN 39; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..442
FT                   /note="F-box only protein 39"
FT                   /id="PRO_0000119935"
FT   DOMAIN          16..61
FT                   /note="F-box"
FT   VARIANT         10
FT                   /note="P -> S (in dbSNP:rs4796555)"
FT                   /id="VAR_024444"
FT   VARIANT         166
FT                   /note="Y -> C (in dbSNP:rs16956264)"
FT                   /id="VAR_049050"
FT   VARIANT         221
FT                   /note="S -> T (in dbSNP:rs4143218)"
FT                   /id="VAR_049051"
FT   VARIANT         231
FT                   /note="L -> F (in dbSNP:rs1509123)"
FT                   /id="VAR_024445"
FT   VARIANT         363
FT                   /note="I -> M (in dbSNP:rs7213731)"
FT                   /id="VAR_024446"
SQ   SEQUENCE   442 AA;  52646 MW;  32A1E4D69FA29C71 CRC64;
     MDEESELIQP QDQSCWAFLP DLCLCRVFWW LGDRDRSRAA LVCRKWNQMM YSAELWRYRT
     ITFSGRPSRV HASEVESAVW YVKKFGRYLE HLEVKFMNPY NAVLTKKFQV TMRGLLSCLS
     KSNNRLKSLS IQYLELDRLV WRNSIRSSFI SSLSFFLKKM GKRLDYLNLK GARLTVEQGC
     QILDSLSYMR NENVISELNI EDYFSHHLAV YNSPQFKKTM STFHNLVSLN LNYNCISDEL
     LENLCENAST LRTINIKCHV HDPHGQVIWG MSWAKLARQA TNLKVNFFFE RIMKYERLAR
     ILLQEIPIRS ISLRSCYFSD PDCSMRPTLI DLLPTFRHTL QKLTCEFNNN HESLDEELHL
     LIISCRKLFY FKIWAFLDVS FVERILKSQK ERQCALRVFK ARIYTNRYET NEEDKTLQEI
     YRKYRKLIES ELSYFVIVYS VM
//