ID   FBX41_HUMAN             Reviewed;         875 AA.
AC   Q8TF61; G3V0Z7; Q2M1V8;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 5.
DT   10-JUN-2026, entry version 164.
DE   RecName: Full=F-box only protein 41;
GN   Name=FBXO41; Synonyms=FBX41, KIAA1940;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-875.
RC   TISSUE=Brain;
RX   PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XXII. The
RT   complete sequences of 50 new cDNA clones which code for large proteins.";
RL   DNA Res. 8:319-327(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 365-875.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471053; EAW99736.1; -; Genomic_DNA.
DR   EMBL; AB075820; BAB85526.1; -; mRNA.
DR   EMBL; BC112202; AAI12203.1; -; mRNA.
DR   CCDS; CCDS46337.2; -.
DR   RefSeq; NP_001073879.2; NM_001080410.4.
DR   RefSeq; NP_001358318.1; NM_001371389.2.
DR   RefSeq; XP_047299414.1; XM_047443458.1.
DR   RefSeq; XP_047299415.1; XM_047443459.1.
DR   RefSeq; XP_047299416.1; XM_047443460.1.
DR   RefSeq; XP_054196660.1; XM_054340685.1.
DR   RefSeq; XP_054196661.1; XM_054340686.1.
DR   RefSeq; XP_054196662.1; XM_054340687.1.
DR   RefSeq; XP_054196663.1; XM_054340688.1.
DR   PDB; 8S1R; X-ray; 1.98 A; EaE/FaF/GaG/HaH=85-91.
DR   PDBsum; 8S1R; -.
DR   AlphaFoldDB; Q8TF61; -.
DR   SMR; Q8TF61; -.
DR   BioGRID; 127320; 4.
DR   ComplexPortal; CPX-7982; SCF E3 ubiquitin ligase complex, FBXO41 variant.
DR   FunCoup; Q8TF61; 588.
DR   IntAct; Q8TF61; 4.
DR   STRING; 9606.ENSP00000428646; -.
DR   DrugBank; DB12695; Phenethyl Isothiocyanate.
DR   GlyGen; Q8TF61; 1 site.
DR   iPTMnet; Q8TF61; -.
DR   PhosphoSitePlus; Q8TF61; -.
DR   SwissPalm; Q8TF61; -.
DR   BioMuta; FBXO41; -.
DR   DMDM; 387912926; -.
DR   jPOST; Q8TF61; -.
DR   MassIVE; Q8TF61; -.
DR   PaxDb; 9606-ENSP00000428646; -.
DR   PeptideAtlas; Q8TF61; -.
DR   ProteomicsDB; 74561; -.
DR   Antibodypedia; 65168; 58 antibodies from 19 providers.
DR   DNASU; 150726; -.
DR   Ensembl; ENST00000295133.9; ENSP00000295133.6; ENSG00000163013.12.
DR   Ensembl; ENST00000520530.3; ENSP00000430968.2; ENSG00000163013.12.
DR   Ensembl; ENST00000521871.5; ENSP00000428646.1; ENSG00000163013.12.
DR   GeneID; 150726; -.
DR   KEGG; hsa:150726; -.
DR   MANE-Select; ENST00000520530.3; ENSP00000430968.2; NM_001371389.2; NP_001358318.1.
DR   UCSC; uc021vjh.2; human.
DR   AGR; HGNC:29409; -.
DR   ClinPGx; PA134946052; -.
DR   CTD; 150726; -.
DR   DisGeNET; 150726; -.
DR   GeneCards; FBXO41; -.
DR   HGNC; HGNC:29409; FBXO41.
DR   HPA; ENSG00000163013; Tissue enriched (brain).
DR   MIM; 609108; gene.
DR   OpenTargets; ENSG00000163013; -.
DR   VEuPathDB; HostDB:ENSG00000163013; -.
DR   eggNOG; KOG4341; Eukaryota.
DR   GeneTree; ENSGT00530000063713; -.
DR   HOGENOM; CLU_018140_0_0_1; -.
DR   InParanoid; Q8TF61; -.
DR   OMA; CGTTPNC; -.
DR   OrthoDB; 6482165at2759; -.
DR   PAN-GO; Q8TF61; 0 GO annotations based on evolutionary models.
DR   PathwayCommons; Q8TF61; -.
DR   Reactome; R-HSA-8951664; Neddylation.
DR   Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   SignaLink; Q8TF61; -.
DR   Agora; ENSG00000163013; -.
DR   BioGRID-ORCS; 150726; 39 hits in 1197 CRISPR screens.
DR   CD-CODE; FB4E32DD; Presynaptic clusters and postsynaptic densities.
DR   ChiTaRS; FBXO41; human.
DR   GenomeRNAi; 150726; -.
DR   Pharos; Q8TF61; Tbio.
DR   PRO; PR:Q8TF61; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8TF61; protein.
DR   Bgee; ENSG00000163013; Expressed in CA1 field of hippocampus and 166 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; NAS:ComplexPortal.
DR   CDD; cd22109; F-box_FBXO41; 1.
DR   FunFam; 3.80.10.10:FF:000229; F-box only protein 41; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR057038; FBX41/ZN365_Znf-C2H2.
DR   InterPro; IPR052283; GenomicStab_NeuMorph_Reg.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR15739:SF4; F-BOX ONLY PROTEIN 41; 1.
DR   PANTHER; PTHR15739; ZINC FINGER PROTEIN; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF23165; zf-C2H2_FBX41; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Coiled coil; Methylation; Phosphoprotein;
KW   Proteomics identification; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..875
FT                   /note="F-box only protein 41"
FT                   /id="PRO_0000119940"
FT   DOMAIN          496..540
FT                   /note="F-box"
FT   REGION          85..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          165..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          347..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          209..351
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        170..182
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..194
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        347..356
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        359..368
FT                   /note="Gly residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        395..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         360
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT   MOD_RES         478
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT   MOD_RES         479
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT   MOD_RES         762
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT   CONFLICT        454
FT                   /note="S -> T (in Ref. 3; BAB85526)"
FT                   /evidence="ECO:0000305"
FT   STRAND          85..88
FT                   /evidence="ECO:0007829|PDB:8S1R"
SQ   SEQUENCE   875 AA;  94496 MW;  B1491A923068389C CRC64;
     MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG AAAAAAAAAA
     ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP AAPHLLHHHH HHAPLAHFPG
     DLVPASLPCE ELAEPGLVPA AAARYALREI EIPLGELFAR KSVASSACST PPPGPGPGPC
     PGPASASPAS PSPADVAYEE GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE
     LERKAAELET ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK
     QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC GSTPSASLGR
     GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS TGASSRVPAA SQSSGCYDSD
     SLELPRPEEG APEDSGPGGL GTRAQAANGG SERSQPPRSS GLRRQAIQNW QRRPRRHSTE
     GEEGDVSDVG SRTTESEAEG PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS
     RSNEVISPEI LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC
     SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES LLKAAGGNLL
     ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH EVIWALGAGC REIVSLQVAP
     LHPCQQPTRF SNRCLQMIGR CWPHLRALGV GGAGCGVQGL ASLARNCMRL QVLELDHVSE
     ITQEVAAEVC REGLKGLEML VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS
     PEAQKLFEDM VTKLQALRRR PGFSKILHIK VEGGC
//