ID FBXW9_HUMAN Reviewed; 458 AA. AC Q5XUX1; B3KVP7; Q9BT89; DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot. DT 07-OCT-2020, sequence version 3. DT 10-JUN-2026, entry version 173. DE RecName: Full=F-box/WD repeat-containing protein 9; DE AltName: Full=F-box and WD-40 domain-containing protein 9; GN Name=FBXW9; Synonyms=FBW9; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RX PubMed=15520277; DOI=10.1101/gad.1255304; RA Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., Harper J.W.; RT "Systematic analysis and nomenclature of mammalian F-box proteins."; RL Genes Dev. 18:2573-2580(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15057824; DOI=10.1038/nature02399; RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., RA Rubin E.M., Lucas S.M.; RT "The DNA sequence and biology of human chromosome 19."; RL Nature 428:529-535(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Lymph; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [6] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; THR-55 AND SER-59, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Leukemic T-cell; RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [7] RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22814378; DOI=10.1073/pnas.1210303109; RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.; RT "N-terminal acetylome analyses and functional insights of the N-terminal RT acetyltransferase NatB."; RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). RN [8] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; THR-55 AND SER-59, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Liver; RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., RA Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver RT phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}. CC -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}. CC -!- INTERACTION: CC Q5XUX1; P63208: SKP1; NbExp=8; IntAct=EBI-2322729, EBI-307486; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=Q5XUX1-3; Sequence=Displayed; CC Name=2; CC IsoId=Q5XUX1-2; Sequence=VSP_060706, VSP_060707; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY736034; AAU50678.1; -; mRNA. DR EMBL; AK123037; BAG53859.1; -; mRNA. DR EMBL; AC018761; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC004290; -; NOT_ANNOTATED_CDS; mRNA. DR CCDS; CCDS12278.2; -. [Q5XUX1-3] DR RefSeq; NP_115677.2; NM_032301.3. [Q5XUX1-3] DR AlphaFoldDB; Q5XUX1; -. DR SMR; Q5XUX1; -. DR BioGRID; 123988; 31. DR ComplexPortal; CPX-7785; SCF E3 ubiquitin ligase complex, FBXW9 variant. DR FunCoup; Q5XUX1; 854. DR IntAct; Q5XUX1; 17. DR NDEx; MUSIC2-C5223-FBXW9; Osteosarcoma (U2OS) cell map - Cytosolic protein folding 1 (25 proteins). DR STRING; 9606.ENSP00000376945; -. DR iPTMnet; Q5XUX1; -. DR PhosphoSitePlus; Q5XUX1; -. DR BioMuta; FBXW9; -. DR DMDM; 115311596; -. DR jPOST; Q5XUX1; -. DR MassIVE; Q5XUX1; -. DR PaxDb; 9606-ENSP00000376945; -. DR PeptideAtlas; Q5XUX1; -. DR ProteomicsDB; 65848; -. [Q5XUX1-2] DR ProteomicsDB; 65849; -. [Q5XUX1-3] DR Pumba; Q5XUX1; -. DR Antibodypedia; 26106; 102 antibodies from 15 providers. DR DNASU; 84261; -. DR Ensembl; ENST00000393261.8; ENSP00000376945.3; ENSG00000132004.14. [Q5XUX1-3] DR Ensembl; ENST00000587955.1; ENSP00000465387.1; ENSG00000132004.14. [Q5XUX1-2] DR GeneID; 84261; -. DR KEGG; hsa:84261; -. DR MANE-Select; ENST00000393261.8; ENSP00000376945.3; NM_032301.3; NP_115677.2. DR UCSC; uc002mum.2; human. [Q5XUX1-3] DR AGR; HGNC:28136; -. DR ClinPGx; PA134910095; -. DR CTD; 84261; -. DR GeneCards; FBXW9; -. DR HGNC; HGNC:28136; FBXW9. DR HPA; ENSG00000132004; Low tissue specificity. DR MIM; 609074; gene. DR OpenTargets; ENSG00000132004; -. DR VEuPathDB; HostDB:ENSG00000132004; -. DR eggNOG; KOG0274; Eukaryota. DR GeneTree; ENSGT00390000006806; -. DR HOGENOM; CLU_034344_0_0_1; -. DR InParanoid; Q5XUX1; -. DR OMA; WAGDNGG; -. DR OrthoDB; 71437at2759; -. DR PAN-GO; Q5XUX1; 0 GO annotations based on evolutionary models. DR PhylomeDB; Q5XUX1; -. DR PathwayCommons; Q5XUX1; -. DR Reactome; R-HSA-390471; Association of TriC/CCT with target proteins during biosynthesis. DR Reactome; R-HSA-8951664; Neddylation. DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation. DR SignaLink; Q5XUX1; -. DR Agora; ENSG00000132004; -. DR BioGRID-ORCS; 84261; 18 hits in 1189 CRISPR screens. DR ChiTaRS; FBXW9; human. DR GenomeRNAi; 84261; -. DR Pharos; Q5XUX1; Tdark. DR PRO; PR:Q5XUX1; -. DR Proteomes; UP000005640; Chromosome 19. DR RNAct; Q5XUX1; protein. DR Bgee; ENSG00000132004; Expressed in right uterine tube and 133 other cell types or tissues. DR ExpressionAtlas; Q5XUX1; baseline and differential. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; NAS:ComplexPortal. DR FunFam; 2.130.10.10:FF:000959; F-box and WD repeat domain containing 9; 1. DR FunFam; 2.130.10.10:FF:000842; F-box and WD repeat domain-containing 9; 1. DR FunFam; 1.20.1280.50:FF:000062; F-box/WD repeat-containing protein 9 isoform X2; 1. DR Gene3D; 1.20.1280.50; -; 1. DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2. DR InterPro; IPR036047; F-box-like_dom_sf. DR InterPro; IPR001810; F-box_dom. DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf. DR InterPro; IPR020472; WD40_PAC1. DR InterPro; IPR019775; WD40_repeat_CS. DR InterPro; IPR036322; WD40_repeat_dom_sf. DR InterPro; IPR001680; WD40_rpt. DR PANTHER; PTHR19855:SF34; F-BOX_WD REPEAT-CONTAINING PROTEIN 9; 1. DR PANTHER; PTHR19855; WD40 REPEAT PROTEIN 12, 37; 1. DR Pfam; PF12937; F-box-like; 1. DR Pfam; PF00400; WD40; 2. DR PRINTS; PR00320; GPROTEINBRPT. DR SMART; SM00256; FBOX; 1. DR SMART; SM00320; WD40; 6. DR SUPFAM; SSF81383; F-box domain; 1. DR SUPFAM; SSF50978; WD40 repeat-like; 1. DR PROSITE; PS50181; FBOX; 1. DR PROSITE; PS00678; WD_REPEATS_1; 2. DR PROSITE; PS50082; WD_REPEATS_2; 3. DR PROSITE; PS50294; WD_REPEATS_REGION; 1. PE 1: Evidence at protein level; KW Acetylation; Alternative splicing; Phosphoprotein; KW Proteomics identification; Reference proteome; Repeat; KW Ubl conjugation pathway; WD repeat. FT CHAIN 1..458 FT /note="F-box/WD repeat-containing protein 9" FT /id="PRO_0000050999" FT DOMAIN 76..123 FT /note="F-box" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080" FT REPEAT 171..210 FT /note="WD 1" FT /evidence="ECO:0000255" FT REPEAT 220..261 FT /note="WD 2" FT /evidence="ECO:0000255" FT REPEAT 264..301 FT /note="WD 3" FT /evidence="ECO:0000255" FT REPEAT 305..342 FT /note="WD 4" FT /evidence="ECO:0000255" FT REPEAT 344..381 FT /note="WD 5" FT /evidence="ECO:0000255" FT REPEAT 387..424 FT /note="WD 6" FT /evidence="ECO:0000255" FT REPEAT 427..458 FT /note="WD 7" FT /evidence="ECO:0000255" FT REGION 1..30 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 42..64 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 16..26 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 1 FT /note="N-acetylmethionine" FT /evidence="ECO:0007744|PubMed:22814378" FT MOD_RES 18 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569" FT MOD_RES 55 FT /note="Phosphothreonine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:23186163" FT MOD_RES 59 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:19690332, FT ECO:0007744|PubMed:23186163" FT VAR_SEQ 128..137 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_060706" FT VAR_SEQ 294 FT /note="R -> RDRMETRDALMGWGGPSRGSDIPPHRPITHE (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_060707" FT VARIANT 70 FT /note="R -> K (in dbSNP:rs6511833)" FT /id="VAR_057599" FT VARIANT 219 FT /note="T -> A (in dbSNP:rs10424623)" FT /id="VAR_062097" SQ SEQUENCE 458 AA; 50760 MW; A2A5B378211A3D06 CRC64; MELPLGRCDD SRTWDDDSDP ESETDPDAQA KAYVARVLSP PKSGLAFSRP SQLSTPAASP SASEPRAASR VSAVSEPGLL SLPPELLLEI CSYLDARLVL HVLSRVCHAL RDLVSDHVTW RLRALRRVRA PYPVVEEKNF DWPAACIALE QHLSRWAEDG RWVEYFCLAE GHVASVDSVL LLQGGSLCLS GSRDRNVNLW DLRQLGTESN QVLIKTLGTK RNSTHEGWVW SLAAQDHRVC SGSWDSTVKL WDMAADGQQF GEIKASSAVL CLSYLPDILV TGTYDKKVTI YDPRAGPALL KHQQLHSRPV LTLLADDRHI ISGSEDHTLV VVDRRANSVL QRLQLDSYLL CMSYQEPQLW AGDNQGLLHV FANRNGCFQL IRSFDVGHSF PITGIQYSVG ALYTTSTDKT IRVHVPTDPP RTICTRRHDN GLNRVCAEGN LVVAGSGDLS LEVWRLQA //