FGF10, also called keratinocyte growth factor 2 (KGF-2), is a secreted, heparin-binding member of the fibroblast growth factor family (FGF7 subfamily with FGF3, FGF7 and FGF22). It is made as a precursor with a cleaved N-terminal signal peptide and is produced mainly by mesenchymal and stromal fibroblasts, from which it acts in a paracrine manner on adjacent epithelium. FGF10 binds selectively to the epithelial IIIb splice isoforms of FGF receptors, principally FGFR2b and also FGFR1b, in ternary complexes stabilized by heparan sulfate proteoglycans, which also retain it in the pericellular matrix and basement membrane. Receptor activation drives FRS2-GRB2-SOS-RAS-ERK, PI3K-AKT and PLC-gamma signalling in target epithelial cells. FGF10 is the key mesenchymal signal that induces and directs epithelial bud outgrowth and branching morphogenesis, acting as a mitogen and chemoattractant for distal lung epithelium and being required for development of the lungs, limbs, salivary and lacrimal glands and other branched epithelial organs. It also stimulates proliferation and migration of keratinocytes, urothelium and other epithelia during repair. Heterozygous loss-of-function variants cause aplasia of lacrimal and salivary glands (ALSG) and lacrimo-auriculo-dento-digital syndrome (LADD3). Recombinant FGF10 has been reported to accumulate in urothelial cell nuclei after uptake, but its physiological action is extracellular.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001525 angiogenesis | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Ensembl Compara transfer of angiogenesis from rat Fgf10. Reason: FGF10 acts through the epithelial IIIb receptor isoforms and is not an endothelial mitogen or established angiogenic factor; any vascular effects in rodent tissue are likely indirect consequences of epithelial-mesenchymal signalling. Not supported by human data. Supporting Evidence: PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0001656 metanephros development | IEP PMID:18437684 Involvement of FGF and BMP family proteins and VEGF in early... | KEEP AS NON CORE | Summary: Immunohistochemical detection of FGF10 in all metanephric structures of 5-9 week human embryos. Reason: Expression-pattern evidence only, but consistent with FGF10 as a mesenchymal signal in kidney development (renal anomalies are reported in LADD syndrome). A developmental, non-core role. Supporting Evidence: PMID:18437684 FGF-10 positive cells appeared in all metanephric structures already in the 5th week |
| GO:0001823 mesonephros development | IEP PMID:18437684 Involvement of FGF and BMP family proteins and VEGF in early... | MARK AS OVER ANNOTATED | Summary: Immunohistochemical detection of FGF10 (and other FGFs/BMPs) in human mesonephros. Reason: Presence of the protein in a transient embryonic organ is expression evidence only and does not show that FGF10 does any of the work of mesonephros development; no functional data support this. Supporting Evidence: PMID:18437684 In the mesonephros, both FGF's and BMP's were found in all structures |
| GO:0005104 fibroblast growth factor receptor binding | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: Recombinant human FGF10 triggers heparin-dependent tyrosine phosphorylation of urothelial cell-surface receptors and is mitogenic for urothelial cells, consistent with FGF receptor binding. Reason: FGF receptor binding is the core molecular activity of FGF10 as a secreted ligand. The more specific child GO:0005111 (type 2 FGF receptor binding, i.e. FGFR2) is separately supported by IBA and by the FGF10-FGFR2b crystal structure; FGF10 also activates FGFR1b, so the general parent term remains correct and is the level used for canonical paracrine FGF ligands. Supporting Evidence: PMID:11923311 a signaling cascade that begins with the heparin-dependent phosphorylation of tyrosine residues of surface transmembrane receptors PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro file:human/FGF10/FGF10-uniprot.txt Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. |
| GO:0005111 type 2 fibroblast growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: FGF10, like FGF7, is a selective ligand of the epithelial IIIb isoform of FGFR2; the PAINT node for the FGF7/FGF10 clade places type 2 FGF receptor binding at the correct specificity. Reason: Phylogenetically placed and directly supported for FGF10 by the FGF10-FGFR2b co-crystal structure and mutagenesis. The target appearing in its own WITH/FROM reflects its own experimental grounding. Supporting Evidence: PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). PMID:12591959 Structure-based mutagenesis of FGF10 confirms the importance of the observed contacts for FGF10 biological activity. file:human/FGF10/FGF10-uniprot.txt Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. file:human/FGF10/FGF10-deep-research-falcon.md FGF10 signals predominantly through FGFR2b, the epithelial IgIIIb splice isoform of fibroblast growth factor receptor 2 |
| GO:0005111 type 2 fibroblast growth factor receptor binding | IPI PMID:19224135 Construction and characterization of a high activity mutant ... | ACCEPT | Summary: Wild-type and a mutant (STEA) human KGF-2/FGF10 bind FGFR2 (IIIb isoform recorded as the interactor) and stimulate epithelial proliferation. Reason: Consistent with the well-established FGF10-FGFR2b interaction; the specific term is appropriate. Supporting Evidence: PMID:19224135 STEA possesses higher receptor binding affinity and promotes better proliferation activity on rat tracheal epithelium (RTE) cells than recombinant human KGF-2 PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005515 protein binding | IPI PMID:12591959 Structural basis by which alternative splicing confers speci... | MODIFY | Summary: Crystal structure of FGF10 bound to the ligand-binding portion of FGFR2b; this IPI records FGF10-FGFR2 binding. Reason: Generic protein binding is uninformative. The partner is FGFR2 (IIIb isoform), so the informative term is type 2 fibroblast growth factor receptor binding (GO:0005111), which this structural paper directly supports. Proposed replacements: type 2 fibroblast growth factor receptor binding Supporting Evidence: PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). PMID:12591959 Structure-based mutagenesis of FGF10 confirms the importance of the observed contacts for FGF10 biological activity. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: High-throughput in situ proximity ligation screen in HeLa cells recording an FGF10-FGFR2 proximity signal. Reason: Generic protein binding is uninformative, and a proximity-ligation screen by itself does not establish a specific molecular function; the abstract does not describe the FGF10 result. Removal does not dispute the interaction: the FGF10-FGFR2 receptor-binding function is already captured by GO:0005111 with structural and IBA support. Supporting Evidence: PMID:25241761 employed a highly sensitive and specific technique, an in situ proximity ligation assay, to investigate 1204 endogenous PPIs in HeLa cells PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Yeast two-hybrid interaction with SREK1IP1 from the HuRI binary interactome map. Reason: Generic protein binding is uninformative. SREK1IP1 is a nuclear splicing-regulator-interacting protein with no known role in FGF biology, and FGF10 is a signal-peptide-bearing secreted ligand; there is no evidence that this Y2H pair corresponds to a physiological function. Removal does not claim the binary interaction is false. Supporting Evidence: PMID:32296183 A reference map of the human binary protein interactome file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Yeast two-hybrid interaction with THAP1 from the HuRI binary interactome map. Reason: Generic protein binding is uninformative. THAP1 is a nuclear transcription factor, whereas FGF10 is a secreted ligand; no functional link is known. Removal does not claim the binary interaction is false. Supporting Evidence: PMID:32296183 A reference map of the human binary protein interactome file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | IBA GO_REF:0000033 | ACCEPT | Summary: Family-level PAINT placement of extracellular activity for canonical secreted FGFs. Reason: FGF10 has a cleaved N-terminal signal peptide and is secreted by mesenchymal fibroblasts to act on neighbouring epithelium; the extracellular region is where it engages heparan sulfate and FGFR2b. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted file:human/FGF10/FGF10-uniprot.txt SIGNAL 1..37 PMID:16597614 Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites |
| GO:0005576 extracellular region | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | ACCEPT | Summary: FGF10 synthesized by lamina propria fibroblasts is secreted and transported in a paracrine manner to urothelium and smooth muscle. Reason: FGF10 has a cleaved N-terminal signal peptide and is secreted by mesenchymal fibroblasts to act on neighbouring epithelium; the extracellular region is where it engages heparan sulfate and FGFR2b. Supporting Evidence: PMID:16597614 Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites |
| GO:0005576 extracellular region | IEA GO_REF:0000120 | ACCEPT | Summary: Secreted localization from the UniProt subcellular location mapping. Reason: FGF10 has a cleaved N-terminal signal peptide and is secreted by mesenchymal fibroblasts to act on neighbouring epithelium; the extracellular region is where it engages heparan sulfate and FGFR2b. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190245 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190260 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190408 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190427 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033472 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033474 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033486 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033488 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077421 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077424 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654147 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654149 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654157 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654159 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654165 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654167 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654397 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654399 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654404 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654407 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654511 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654560 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654562 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654569 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654571 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654573 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654575 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654578 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654582 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654584 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654587 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654591 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654592 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654594 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654596 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654597 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654600 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654603 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654605 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654607 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654608 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654672 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654673 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654690 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654692 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654748 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655268 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655301 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655339 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655343 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5656064 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5656070 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: FGF10 participates in this Reactome reaction as the secreted ligand bound to FGFR2b or FGFR1b (wild-type or mutant) at the cell surface; one of many source-distinct Reactome rows for the same extracellular location. Reason: The extracellular region is correct for the ligand component of FGF10-FGFR(b) complexes. Retained as a valid, redundant location record. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0005634 nucleus | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | KEEP AS NON CORE | Summary: Exogenously added recombinant FGF10 was observed in urothelial cell nuclei. Reason: Experimental observation from one group (Bassuk laboratory) using recombinant protein added to cultured urothelial cells. FGF10 acts primarily as an extracellular ligand; nuclear accumulation after internalization is plausible (as for FGF1/FGF2) but its physiological significance is not established independently. Retained as a non-core location rather than second-guessing the curator. Supporting Evidence: PMID:11923311 translocation of rFGF-10 into urothelial cell nuclei PMID:17471512 has been identified inside urothelial cells, despite its acknowledged role as an extracellular signaling ligand |
| GO:0005634 nucleus | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | KEEP AS NON CORE | Summary: FGF10 and its receptor were visualized at the urothelial cell surface, in cytoplasm and within nuclei. Reason: Real observation but secondary to the extracellular ligand function; see the other nucleus rows. Supporting Evidence: PMID:16597614 captured FGF-10 and its receptor in association with the urothelial cell surface, in cytoplasm, and within nuclei PMID:17471512 has been identified inside urothelial cells, despite its acknowledged role as an extracellular signaling ligand |
| GO:0005634 nucleus | IDA PMID:17471512 Translocation of fibroblast growth factor-10 and its recepto... | KEEP AS NON CORE | Summary: Recombinant FGF10 localizes strongly to nuclei of cultured urothelial cells, partly dependent on an NLS-like motif. Reason: Direct experimental localization of internalized recombinant FGF10; the authors themselves note this contrasts with its acknowledged extracellular role. Non-core. Supporting Evidence: PMID:17471512 Recombinant (r)FGF-10 was determined by fluorescence microscopy optical sectioning to localize strongly to nuclei inside cultured urothelial cells. PMID:17471512 has been identified inside urothelial cells, despite its acknowledged role as an extracellular signaling ligand |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | REMOVE | Summary: Whole-family PAINT node (PTN000160075) propagating cytoplasm, driven by intracellular or non-classically secreted FGFs. Reason: FGF10 carries a cleaved N-terminal signal peptide (1-37) and acts as a secreted paracrine ligand. The cytoplasm annotation reflects FGF family members lacking signal peptides (e.g. FGF1/FGF2, intracellular FGF11-14) and is an over-propagation to a classically secreted FGF. This matches the treatment of the same node for FGF7. The occasional cytoplasmic signal of internalized recombinant FGF10 does not make cytoplasm a site where it is active. Propagation Review Root cause: PROPAGATION BAD Failure modes: COMPARTMENT OR COMPLEX MISMATCH FUNCTIONAL DIVERGENCE Sources checked: PANTHER:PTN000160075 SUPPORTS SOURCE BUT NOT TARGET FGF family root node; spans signal-peptide-less FGF1/FGF2 and intracellular FGF homologous factors as well as classically secreted paracrine FGFs such as FGF10. UniProtKB:P05230 · FGF1 SUPPORTS SOURCE BUT NOT TARGET FGF1 lacks a classical signal peptide and has intracellular/nuclear pools; this does not transfer to signal-peptide-bearing FGF10. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt SIGNAL 1..37 file:human/FGF10/FGF10-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:16597614 Synthesis of FGF-10 was restricted to mesenchymal fibroblasts, and secreted FGF-10 exhibited paracrine transport to two proximal sites |
| GO:0005886 plasma membrane | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | MODIFY | Summary: FGF10 was seen in association with the urothelial cell surface (with its receptor). Reason: FGF10 is a secreted ligand without a membrane anchor; it associates with the plasma membrane only by binding FGFR2b and heparan sulfate proteoglycans on the outer face of the cell. Cell surface (GO:0009986) describes this observation more accurately than plasma membrane. Proposed replacements: cell surface Supporting Evidence: PMID:16597614 captured FGF-10 and its receptor in association with the urothelial cell surface, in cytoplasm, and within nuclei |
| GO:0007431 salivary gland development | IMP PMID:17213838 FGF10 missense mutations in aplasia of lacrimal and salivary... | ACCEPT | Summary: Heterozygous FGF10 missense mutations cause aplasia of lacrimal and salivary glands (ALSG) in humans. Reason: Human genetic loss-of-function evidence (with mouse Fgf10 haploinsufficiency phenocopying) shows FGF10 is the mesenchymal signal that drives salivary gland epithelial budding and branching. FGF10 does the instructive signalling work in this process, which is one of its defining in vivo roles. Supporting Evidence: PMID:17213838 two families with ALSG associated with missense mutations (R80S and G138E, respectively) affecting highly conserved residues in FGF10 PMID:19102732 Recent studies and our findings suggest that changed FGF10 signaling due to haploinsufficiency during development results in ALSG. |
| GO:0008083 growth factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: Family-level PAINT inference of growth factor activity for canonical FGFs, including FGF10. Reason: Growth factor activity is the core molecular function of FGF10: a secreted ligand that binds FGFR2b (and FGFR1b) on epithelial cells and stimulates their proliferation, survival and migration. Supporting Evidence: PMID:15690149 human embryonic pancreatic mesenchyme expresses FGF7 and FGF10 that act on epithelial cells to activate their proliferation PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro |
| GO:0008083 growth factor activity | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: Recombinant human FGF10 is a mitogen for human urothelial cells in vitro and for transitional epithelium in vivo. Reason: Growth factor activity is the core molecular function of FGF10: a secreted ligand that binds FGFR2b (and FGFR1b) on epithelial cells and stimulates their proliferation, survival and migration. Supporting Evidence: PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro |
| GO:0008083 growth factor activity | IDA PMID:15690149 Fibroblast growth factors 7 and 10 are expressed in the huma... | ACCEPT | Summary: FGF10 expressed by human embryonic pancreatic mesenchyme induces proliferation of pancreatic epithelial cells. Reason: Growth factor activity is the core molecular function of FGF10: a secreted ligand that binds FGFR2b (and FGFR1b) on epithelial cells and stimulates their proliferation, survival and migration. Supporting Evidence: PMID:15690149 human embryonic pancreatic mesenchyme expresses FGF7 and FGF10 that act on epithelial cells to activate their proliferation |
| GO:0008083 growth factor activity | IEA GO_REF:0000002 | ACCEPT | Summary: InterPro FGF family (IPR002209) mapping to growth factor activity. Reason: Growth factor activity is the core molecular function of FGF10: a secreted ligand that binds FGFR2b (and FGFR1b) on epithelial cells and stimulates their proliferation, survival and migration. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. PMID:15690149 human embryonic pancreatic mesenchyme expresses FGF7 and FGF10 that act on epithelial cells to activate their proliferation |
| GO:0008201 heparin binding | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: FGF10 signalling is heparin-dependent; FGF10 binds heparin/heparan sulfate, which acts as co-receptor and extracellular reservoir. Reason: Heparin/heparan sulfate binding is a conserved property of paracrine FGFs and is directly shown for FGF10 by SPR binding to perlecan heparan sulfate. It is a genuine molecular activity that contributes to FGFR complex formation and to local retention of the ligand. Supporting Evidence: PMID:11923311 a signaling cascade that begins with the heparin-dependent phosphorylation of tyrosine residues of surface transmembrane receptors PMID:17959718 surface plasmon resonance (SPR) analysis showed that FGF10 and the FGF10-FGFR2b complex bound to purified perlecan HS |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | ACCEPT | Summary: Family-level PAINT inference of positive regulation of cell proliferation. Reason: FGF10 is an epithelial mitogen; the more specific GO:0050679 is supported experimentally. The general term is correct. Supporting Evidence: PMID:15690149 human embryonic pancreatic mesenchyme expresses FGF7 and FGF10 that act on epithelial cells to activate their proliferation PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: PAINT inference of FGF receptor signalling pathway for canonical FGFs. Reason: FGF10 is the ligand that initiates FGFR2b (and FGFR1b) signalling; ligands are conventionally annotated to the FGFR signalling pathway. Supporting Evidence: PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). PMID:17500053 signaling by Fgf10 (fibroblast growth factor 10) and its receptor Fgfr2b is critical for induction of a gene network that controls proliferation, differentiation, and branching of the epithelial tubules |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: FGF10 triggers heparin-dependent tyrosine phosphorylation of surface receptors in urothelial cells. Reason: FGF10 is the ligand that initiates FGFR2b (and FGFR1b) signalling; ligands are conventionally annotated to the FGFR signalling pathway. Supporting Evidence: PMID:11923311 a signaling cascade that begins with the heparin-dependent phosphorylation of tyrosine residues of surface transmembrane receptors |
| GO:0009986 cell surface | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | ACCEPT | Summary: FGF10 visualized in association with the urothelial cell surface. Reason: FGF10 is retained at the cell surface and in the pericellular matrix bound to heparan sulfate proteoglycans and FGFR2b, which is where it signals. Supporting Evidence: PMID:16597614 captured FGF-10 and its receptor in association with the urothelial cell surface, in cytoplasm, and within nuclei |
| GO:0009986 cell surface | IDA PMID:17959718 Heparanase cleavage of perlecan heparan sulfate modulates FG... | ACCEPT | Summary: FGF10-FGFR2b complex binds perlecan/syndecan heparan sulfate in the submandibular gland basement membrane and epithelium. Reason: FGF10 is retained at the cell surface and in the pericellular matrix bound to heparan sulfate proteoglycans and FGFR2b, which is where it signals. Supporting Evidence: PMID:17959718 surface plasmon resonance (SPR) analysis showed that FGF10 and the FGF10-FGFR2b complex bound to purified perlecan HS |
| GO:0009986 cell surface | NAS PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: Authors propose FGF10 levels rise at the urothelial cell surface during proliferative phases. Reason: FGF10 is retained at the cell surface and in the pericellular matrix bound to heparan sulfate proteoglycans and FGFR2b, which is where it signals. Supporting Evidence: PMID:11923311 During proliferative phases, levels of FGF-10 rise at the urothelial cell surface and/or within urothelial cell nuclei. |
| GO:0010634 positive regulation of epithelial cell migration | IDA PMID:17500053 Cathespin H is an Fgf10 target involved in Bmp4 degradation ... | KEEP AS NON CORE | Summary: Mouse lung explant study of Fgf10-Fgfr2b targets (cathepsin H) in branching morphogenesis. Reason: The abstract focuses on Fgf10 induction of Ctsh and Bmp4 regulation and does not describe the migration assay; the full text (not cached) presumably does. FGF10 promoting epithelial migration is well supported elsewhere (lung bud chemoattraction, keratinocyte migration), so the annotation is biologically plausible and is retained as non-core rather than overruled. Supporting Evidence: PMID:17500053 signaling by Fgf10 (fibroblast growth factor 10) and its receptor Fgfr2b is critical for induction of a gene network that controls proliferation, differentiation, and branching of the epithelial tubules PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0010838 positive regulation of keratinocyte proliferation | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | ACCEPT | Summary: FGF10 (KGF-2) regulates keratinocyte proliferation through the KGF receptor (FGFR2b). Reason: FGF10 is a keratinocyte mitogen acting through FGFR2b; a specific instance of its core epithelial growth-factor role. Supporting Evidence: PMID:17449030 regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR) PMID:19152659 measurement of the proliferation of cell lines expressing FGF receptor-2-IIIb |
| GO:0022008 neurogenesis | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Family-root PAINT inference of neurogenesis. Reason: Mouse Fgf10 has a reported role in the neuroepithelial-to-radial glia transition in cortex (source of the ISS/IEA radial glial differentiation rows), so a neural developmental role is plausible, but it is peripheral to FGF10's epithelial paracrine function. Supporting Evidence: PMID:12591959 FGF7 and FGF10 activate only the b isoform of FGFR2 (FGFR2b). |
| GO:0030036 actin cytoskeleton organization | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | KEEP AS NON CORE | Summary: FGF10 induces lamellipodia/ruffles and cortical actin assembly in keratinocytes via cortactin. Reason: A downstream cellular response to FGFR2b signalling, not a function executed by FGF10 itself. Supporting Evidence: PMID:17449030 Both growth factors promoted phosphorylation and subsequent membrane translocation of cortactin PMID:17449030 These results indicate that cortactin is involved in keratinocyte migration promoted by both KGF and FGF10. |
| GO:0030154 cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ensembl Compara transfer of cell differentiation from rat Fgf10. Reason: Very general; FGF10 influences epithelial differentiation in several organs, but this is a broad downstream developmental outcome. Supporting Evidence: PMID:17500053 signaling by Fgf10 (fibroblast growth factor 10) and its receptor Fgfr2b is critical for induction of a gene network that controls proliferation, differentiation, and branching of the epithelial tubules |
| GO:0030334 regulation of cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PAINT inference of regulation of cell migration. Reason: FGF10 promotes epithelial/keratinocyte migration and attracts lung epithelial buds; correct but secondary to its growth-factor/receptor-ligand role. Supporting Evidence: PMID:17449030 These results indicate that cortactin is involved in keratinocyte migration promoted by both KGF and FGF10. PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. |
| GO:0032355 response to estradiol | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Ensembl Compara transfer of response to estradiol from rat Fgf10. Reason: Almost certainly reflects estrogen-regulated Fgf10 expression in rodent tissue, i.e. a change in the gene's expression rather than a function of the protein in responding to estradiol. Supporting Evidence: file:human/FGF10/FGF10-uniprot.txt normal branching morphogenesis. May play a role in wound healing. |
| GO:0032496 response to lipopolysaccharide | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Ensembl Compara transfer of response to lipopolysaccharide from rat Fgf10. Reason: TLR2/TLR4 activation suppresses Fgf10 expression in developing lung; this is regulation of FGF10 expression by LPS, not participation of FGF10 in the LPS response. Supporting Evidence: PMID:17071719 activation of Toll-like receptor 2 (TLR2) or Toll-like receptor 4 (TLR4) inhibited FGF-10 expression |
| GO:0032781 positive regulation of ATP-dependent activity | IDA PMID:12804770 Fibroblast growth factor-10 upregulates Na,K-ATPase via the ... | KEEP AS NON CORE | Summary: FGF10 rapidly increases Na,K-ATPase activity in alveolar epithelial cells by recruiting the pump to the plasma membrane via Grb2-SOS/Ras/MAPK. Reason: An indirect downstream consequence of FGFR-MAPK signalling in alveolar epithelial cells; FGF10 does not act on the ATPase directly. Supporting Evidence: PMID:12804770 we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway |
| GO:0032808 lacrimal gland development | IMP PMID:17213838 FGF10 missense mutations in aplasia of lacrimal and salivary... | ACCEPT | Summary: FGF10 mutations cause lacrimal gland aplasia/hypoplasia in ALSG. Reason: As for salivary gland development: human haploinsufficiency evidence for FGF10 as the mesenchymal inductive signal for lacrimal gland development. Supporting Evidence: PMID:17213838 two families with ALSG associated with missense mutations (R80S and G138E, respectively) affecting highly conserved residues in FGF10 PMID:19102732 Recent studies and our findings suggest that changed FGF10 signaling due to haploinsufficiency during development results in ALSG. |
| GO:0034394 protein localization to cell surface | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | MARK AS OVER ANNOTATED | Summary: FGF10 induces membrane translocation of cortactin in keratinocytes. Reason: Cortactin relocates to cortical actin at the plasma membrane, not to the cell surface; this is a downstream signalling consequence rather than a protein-localization-to-cell-surface process executed by FGF10 (same treatment as for FGF7). Supporting Evidence: PMID:17449030 Both growth factors promoted phosphorylation and subsequent membrane translocation of cortactin |
| GO:0042056 chemoattractant activity | IBA GO_REF:0000033 | ACCEPT | Summary: PAINT inference of chemoattractant activity for the FGF10 clade, grounded in FGF10's own experimental data. Reason: FGF10 acts as a directional cue for epithelial buds: a localized FGF10 source attracts distal lung epithelium, a classic chemoattractant activity mediated through FGFR2b. Supporting Evidence: PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0042056 chemoattractant activity | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | ACCEPT | Summary: FGF10 promotes migration of human keratinocytes (less efficiently than FGF7), via Src/PI3K and cortactin. Reason: The paper documents FGF10-promoted keratinocyte motility; whether this is directional chemoattraction cannot be established from the abstract, but chemoattractant activity is well established for FGF10 (PMID:9740653), so the curator's annotation is accepted. Supporting Evidence: PMID:17449030 FGF10 is less efficient than KGF in promoting migration PMID:17449030 These results indicate that cortactin is involved in keratinocyte migration promoted by both KGF and FGF10. |
| GO:0042056 chemoattractant activity | IDA PMID:9740653 FGF-10 is a chemotactic factor for distal epithelial buds du... | ACCEPT | Summary: FGF10-soaked heparin beads attract distal lung epithelial buds in lung explant culture. Reason: FGF10 acts as a directional cue for epithelial buds: a localized FGF10 source attracts distal lung epithelium, a classic chemoattractant activity mediated through FGFR2b. Supporting Evidence: PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0042056 chemoattractant activity | IEA GO_REF:0000107 | ACCEPT | Summary: Ensembl Compara transfer of chemoattractant activity from mouse Fgf10. Reason: FGF10 acts as a directional cue for epithelial buds: a localized FGF10 source attracts distal lung epithelium, a classic chemoattractant activity mediated through FGFR2b. Supporting Evidence: PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. |
| GO:0042060 wound healing | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: PAINT inference of wound healing for the FGF7/FGF10 clade. Reason: FGF10 (KGF-2) is released after injury and stimulates keratinocyte proliferation and migration, contributing to re-epithelialization; recombinant FGF10 (repifermin) accelerates wound closure. Real, but secondary to the core ligand function and partly pharmacological. Supporting Evidence: PMID:19152659 FGF-10 and DS markedly enhanced migration of keratinocytes in an in vitro wound scratch assay file:human/FGF10/FGF10-uniprot.txt normal branching morphogenesis. May play a role in wound healing. |
| GO:0042060 wound healing | IDA PMID:11896977 Randomized trial of topically applied repifermin (recombinan... | KEEP AS NON CORE | Summary: Randomized trial: topical recombinant FGF10 (repifermin) accelerated closure of venous ulcers. Reason: FGF10 (KGF-2) is released after injury and stimulates keratinocyte proliferation and migration, contributing to re-epithelialization; recombinant FGF10 (repifermin) accelerates wound closure. Real, but secondary to the core ligand function and partly pharmacological. This evidence is a therapeutic effect of exogenous protein rather than a demonstration of the endogenous role. Supporting Evidence: PMID:11896977 Repifermin was shown to accelerate wound healing, with significantly more patients achieving 75% wound closure with repifermin than with placebo. |
| GO:0042060 wound healing | IDA PMID:19152659 FGF-10 and specific structural elements of dermatan sulfate ... | KEEP AS NON CORE | Summary: FGF10 with dermatan sulfate enhances keratinocyte migration in an in vitro wound scratch assay. Reason: FGF10 (KGF-2) is released after injury and stimulates keratinocyte proliferation and migration, contributing to re-epithelialization; recombinant FGF10 (repifermin) accelerates wound closure. Real, but secondary to the core ligand function and partly pharmacological. Supporting Evidence: PMID:19152659 FGF-10 and DS markedly enhanced migration of keratinocytes in an in vitro wound scratch assay |
| GO:0042246 tissue regeneration | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ensembl Compara transfer of tissue regeneration from rat Fgf10. Reason: FGF10 contributes to epithelial repair after injury (lung, skin, urothelium); a non-core outcome of its mitogenic signalling. Supporting Evidence: PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: PAINT inference of positive regulation of MAPK cascade for canonical FGFs. Reason: FGF10 binding to FGFR2b activates the FRS2-GRB2-SOS-RAS-RAF-MEK-ERK cascade; positive regulation of MAPK cascade is a direct consequence of its ligand activity and a core pathway output. Supporting Evidence: PMID:12804770 we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway PMID:17959718 heparanase releases FGF10 from perlecan HS in the basement membrane, increasing MAPK signaling, epithelial clefting, and lateral branch formation, which results in increased branching morphogenesis |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:12804770 Fibroblast growth factor-10 upregulates Na,K-ATPase via the ... | ACCEPT | Summary: FGF10 effects in alveolar epithelial cells require Grb2-SOS/Ras/MAPK. Reason: FGF10 binding to FGFR2b activates the FRS2-GRB2-SOS-RAS-RAF-MEK-ERK cascade; positive regulation of MAPK cascade is a direct consequence of its ligand activity and a core pathway output. Supporting Evidence: PMID:12804770 we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:14975937 Fibroblast growth factor-10 attenuates H2O2-induced alveolar... | ACCEPT | Summary: FGF10 induces ERK1/2 phosphorylation via Grb2-SOS/Ras/Raf-1 in A549 and alveolar type II cells. Reason: FGF10 binding to FGFR2b activates the FRS2-GRB2-SOS-RAS-RAF-MEK-ERK cascade; positive regulation of MAPK cascade is a direct consequence of its ligand activity and a core pathway output. Supporting Evidence: PMID:14975937 FGF-10 attenuates H2O2-induced AEC DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair |
| GO:0045739 positive regulation of DNA repair | IDA PMID:14975937 Fibroblast growth factor-10 attenuates H2O2-induced alveolar... | MARK AS OVER ANNOTATED | Summary: FGF10 protection against H2O2-induced DNA damage was blocked by aphidicolin and cold, which the authors interpret as suggesting DNA repair. Reason: The evidence is indirect (pharmacological blockade of a protective effect) and the authors themselves only suggest a role for DNA repair. Any effect is a remote downstream consequence of growth-factor signalling in stressed cells, not a demonstrated regulation of DNA repair by FGF10. Supporting Evidence: PMID:14975937 each blocked the protective effects of FGF-10, suggesting a role for DNA repair PMID:14975937 FGF-10 attenuates H2O2-induced AEC DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair |
| GO:0045893 positive regulation of DNA-templated transcription | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Ensembl Compara transfer from mouse Fgf10 of positive regulation of DNA-templated transcription. Reason: FGF10 induces target genes only indirectly, via receptor signalling (e.g. Ctsh, Bmp4 induction in lung epithelium). Annotating a secreted ligand to transcription regulation over-states its role. Supporting Evidence: PMID:17500053 signaling by Fgf10 (fibroblast growth factor 10) and its receptor Fgfr2b is critical for induction of a gene network that controls proliferation, differentiation, and branching of the epithelial tubules |
| GO:0046579 positive regulation of Ras protein signal transduction | IDA PMID:12804770 Fibroblast growth factor-10 upregulates Na,K-ATPase via the ... | KEEP AS NON CORE | Summary: FGF10 effects in alveolar epithelial cells were blocked by a Ras inhibitor and dominant-negative Ras. Reason: Ras activation downstream of FGFR2b is expected, but the evidence here is inhibitor-based and the more informative core output (positive regulation of MAPK cascade) is already captured. Supporting Evidence: PMID:12804770 we provide first evidence that FGF-10 upregulates (short-term) the Na,K-ATPase activity in AEC via the Grb2-SOS/Ras/MAPK pathway |
| GO:0046877 regulation of saliva secretion | IMP PMID:19102732 An intronic alteration of the fibroblast growth factor 10 ge... | MARK AS OVER ANNOTATED | Summary: ALSG patient with an FGF10 splice mutation shows aplasia of lacrimal puncta and parotid glands with xerostomia. Reason: Reduced saliva is a secondary consequence of glandular aplasia during development; FGF10 is not known to regulate the secretory process of mature salivary acini. The primary role is captured by salivary gland development. Supporting Evidence: PMID:19102732 Recent studies and our findings suggest that changed FGF10 signaling due to haploinsufficiency during development results in ALSG. PMID:19102732 Affected patients suffer from irritable eyes, epiphora (constant tearing) and xerostomia (dryness of the mouth) |
| GO:0048538 thymus development | IDA PMID:17969154 FGFR2IIIb signaling regulates thymic epithelial differentiat... | KEEP AS NON CORE | Summary: Transgenic thymocyte expression of FGF10 alters thymic epithelial differentiation; blocking FGFR2IIIb causes premature thymic involution (mouse). Reason: Supports FGFR2b ligands in thymic epithelial maintenance; the gain-of-function design (ectopic FGF10) plus a pan-FGFR2b blocker does not isolate endogenous FGF10, but mouse Fgf10 is known to be needed for thymic epithelial growth. Developmental, non-core. Supporting Evidence: PMID:17969154 profoundly alters the differentiation and function of thymic epithelium |
| GO:0048754 branching morphogenesis of an epithelial tube | IDA PMID:17959718 Heparanase cleavage of perlecan heparan sulfate modulates FG... | ACCEPT | Summary: FGF10 released from perlecan heparan sulfate drives epithelial clefting and branching in ex vivo submandibular gland culture; FGF10 specifically rescues heparanase inhibition. Reason: Branching morphogenesis of epithelial tubes (lung, salivary, lacrimal, prostate, mammary) is the signature in vivo role of FGF10 as the mesenchymal signal that induces and directs epithelial bud outgrowth; FGF10 does instructive signalling work in the process. Supporting Evidence: PMID:17959718 heparanase releases FGF10 from perlecan HS in the basement membrane, increasing MAPK signaling, epithelial clefting, and lateral branch formation, which results in increased branching morphogenesis PMID:17959718 Inhibition of heparanase activity in organ culture decreased branching morphogenesis, and this inhibition was rescued specifically by FGF10 and not by other FGFs. file:human/FGF10/FGF10-uniprot.txt normal branching morphogenesis. May play a role in wound healing. |
| GO:0050671 positive regulation of lymphocyte proliferation | IDA PMID:19152659 FGF-10 and specific structural elements of dermatan sulfate ... | UNDECIDED | Summary: Proliferation readout of FGF10 activity in 'cell lines expressing FGF receptor-2-IIIb', probably engineered lymphoid reporter lines. Reason: The abstract describes the assay as proliferation of cell lines engineered to express FGFR2IIIb, which in this field are usually BaF3 pro-B cells used as a mitogenesis reporter. If so, the lymphocyte term reflects the reporter cell type rather than a physiological FGF10 function (FGF10 targets epithelial IIIb receptors). The full text could not be retrieved (Europe PMC error) to confirm the cell line, so this experimental annotation is left UNDECIDED rather than removed. Supporting Evidence: PMID:19152659 measurement of the proliferation of cell lines expressing FGF receptor-2-IIIb |
| GO:0050673 epithelial cell proliferation | IDA PMID:19224135 Construction and characterization of a high activity mutant ... | MODIFY | Summary: Wild-type and mutant KGF-2/FGF10 stimulate proliferation of rat tracheal epithelial cells. Reason: FGF10 is an extracellular ligand that stimulates epithelial proliferation; it does not itself carry out the proliferation process. Positive regulation of epithelial cell proliferation (GO:0050679) is the appropriate term. Proposed replacements: positive regulation of epithelial cell proliferation Supporting Evidence: PMID:19224135 STEA possesses higher receptor binding affinity and promotes better proliferation activity on rat tracheal epithelium (RTE) cells than recombinant human KGF-2 |
| GO:0050674 urothelial cell proliferation | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | MODIFY | Summary: Recombinant FGF10 induces proliferation of human urothelial cells. Reason: As a secreted mitogen FGF10 regulates, rather than executes, urothelial cell proliferation; the regulatory term GO:0050677 (already annotated from the same paper) is appropriate. Proposed replacements: positive regulation of urothelial cell proliferation Supporting Evidence: PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro |
| GO:0050677 positive regulation of urothelial cell proliferation | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: Recombinant FGF10 induces proliferation of human urothelial cells in vitro and of transitional epithelium in mice. Reason: FGF10 from lamina propria fibroblasts is a paracrine urothelial mitogen acting via FGFR2b; a specific, experimentally supported instance of its core epithelial mitogenic role. Supporting Evidence: PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro PMID:11923311 fibroblasts of the human lamina propria were the cell type that synthesized FGF-10 RNA |
| GO:0050677 positive regulation of urothelial cell proliferation | IDA PMID:11923311 Fibroblast growth factor-10 is a mitogen for urothelial cell... | ACCEPT | Summary: Recombinant FGF10 induces proliferation of human urothelial cells in vitro and of transitional epithelium in mice. Reason: FGF10 from lamina propria fibroblasts is a paracrine urothelial mitogen acting via FGFR2b; a specific, experimentally supported instance of its core epithelial mitogenic role. Supporting Evidence: PMID:11923311 Recombinant (r) preparations of human FGF-10 were found to induce proliferation of human urothelial cells in vitro PMID:11923311 fibroblasts of the human lamina propria were the cell type that synthesized FGF-10 RNA |
| GO:0050679 positive regulation of epithelial cell proliferation | IDA PMID:15690149 Fibroblast growth factors 7 and 10 are expressed in the huma... | ACCEPT | Summary: FGF10 from human embryonic pancreatic mesenchyme stimulates proliferation of pancreatic epithelial cells. Reason: Core biological output of FGF10: paracrine stimulation of epithelial proliferation via FGFR2b. Supporting Evidence: PMID:15690149 human embryonic pancreatic mesenchyme expresses FGF7 and FGF10 that act on epithelial cells to activate their proliferation |
| GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | KEEP AS NON CORE | Summary: FGF10 induces Src-dependent tyrosine phosphorylation of cortactin in keratinocytes. Reason: Tyrosine phosphorylation of downstream substrates follows FGFR2b kinase activation; true, but a generic downstream consequence rather than a distinct FGF10 function. Supporting Evidence: PMID:17449030 Both growth factors promoted phosphorylation and subsequent membrane translocation of cortactin |
| GO:0050918 positive chemotaxis | IBA GO_REF:0000033 | ACCEPT | Summary: PAINT inference of positive chemotaxis for the FGF10 clade, grounded in FGF10's own data. Reason: FGF10 is an established chemoattractant for distal lung epithelium; ligands providing the directional cue are conventionally annotated to positive chemotaxis. Supporting Evidence: PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0050918 positive chemotaxis | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | ACCEPT | Summary: FGF10 promotes keratinocyte migration. Reason: Keratinocyte motility assays support FGF10 as a motogen; directional chemotaxis is best shown in lung explants (PMID:9740653). The function is correct for the gene, so the curator's annotation is accepted. Supporting Evidence: PMID:17449030 These results indicate that cortactin is involved in keratinocyte migration promoted by both KGF and FGF10. |
| GO:0050918 positive chemotaxis | IDA PMID:9740653 FGF-10 is a chemotactic factor for distal epithelial buds du... | ACCEPT | Summary: Lung epithelial buds grow toward FGF10-soaked beads. Reason: FGF10 is an established chemoattractant for distal lung epithelium; ligands providing the directional cue are conventionally annotated to positive chemotaxis. Supporting Evidence: PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0051549 positive regulation of keratinocyte migration | IDA PMID:17449030 Cortactin involvement in the keratinocyte growth factor and ... | KEEP AS NON CORE | Summary: FGF10 promotes human keratinocyte migration via Src/PI3K and cortactin. Reason: Real downstream cellular effect of FGFR2b activation in skin, relevant to wound repair; secondary to the core ligand function. Supporting Evidence: PMID:17449030 These results indicate that cortactin is involved in keratinocyte migration promoted by both KGF and FGF10. PMID:17449030 FGF10 is less efficient than KGF in promoting migration |
| GO:0051549 positive regulation of keratinocyte migration | IDA PMID:19152659 FGF-10 and specific structural elements of dermatan sulfate ... | KEEP AS NON CORE | Summary: FGF10 together with dermatan sulfate enhances keratinocyte migration in a scratch assay. Reason: As above; downstream epithelial response relevant to wound repair. Supporting Evidence: PMID:19152659 FGF-10 and DS markedly enhanced migration of keratinocytes in an in vitro wound scratch assay |
| GO:0060019 radial glial cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Ensembl Compara transfer from mouse Fgf10 of radial glial cell differentiation. Reason: Transferred from mouse Fgf10, where Fgf10 from the cortical neuroepithelium is reported to promote the transition of neuroepithelial cells to radial glia. Plausible and conserved, but a peripheral developmental role relative to FGF10's epithelial paracrine function, and not tested in human. |
| GO:0060019 radial glial cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Curator ISS transfer from mouse Fgf10 (O35565) of radial glial cell differentiation. Reason: Transferred from mouse Fgf10, where Fgf10 from the cortical neuroepithelium is reported to promote the transition of neuroepithelial cells to radial glia. Plausible and conserved, but a peripheral developmental role relative to FGF10's epithelial paracrine function, and not tested in human. |
| GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing | NAS PMID:19152659 FGF-10 and specific structural elements of dermatan sulfate ... | KEEP AS NON CORE | Summary: Authors state FGF10 is released into wounds and stimulates FGFR2b-expressing epithelial cell proliferation. Reason: Consistent with FGF10's role in re-epithelialization; non-core. Supporting Evidence: PMID:19152659 FGF-10 is abundantly released into wounds following injury, and likely an essential growth factor required for this process. |
| GO:0060428 lung epithelium development | IDA PMID:9740653 FGF-10 is a chemotactic factor for distal epithelial buds du... | KEEP AS NON CORE | Summary: FGF10 directs distal lung epithelial bud outgrowth in explant culture. Reason: Lung epithelial development is a downstream developmental outcome of FGF10 signalling; the more specific and direct role is captured by bud outgrowth involved in lung branching and branching morphogenesis. Supporting Evidence: PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0060430 lung saccule development | IMP PMID:17071719 FGF-10 is decreased in bronchopulmonary dysplasia and suppre... | KEEP AS NON CORE | Summary: Reduced FGF10 (via TLR activation) is associated with abnormal saccular airway morphogenesis; FGF10 is decreased in bronchopulmonary dysplasia. Reason: Supports a role for FGF10 in late lung development; developmental outcome of FGF10 signalling, non-core. Supporting Evidence: PMID:17071719 fibroblast growth factor-10 (FGF-10) is required for saccular lung development |
| GO:0060447 bud outgrowth involved in lung branching | IDA PMID:9740653 FGF-10 is a chemotactic factor for distal epithelial buds du... | ACCEPT | Summary: FGF10 attracts and directs outgrowth of distal lung epithelial buds. Reason: FGF10 is the mesenchymal signal that induces and directs lung bud outgrowth; this is the classic, direct in vivo role of FGF10 (Fgf10-null mice lack lungs). Supporting Evidence: PMID:9740653 FGF-10 exerts a powerful chemoattractant effect on the distal but not on proximal lung epithelium. PMID:9740653 Epithelial buds grow toward an FGF-10 source within 24 h |
| GO:0061033 secretion by lung epithelial cell involved in lung growth | IDA PMID:10541313 KGF and FGF-10 stimulate liquid secretion in human fetal lun... | KEEP AS NON CORE | Summary: FGF10 increases intraluminal volume (liquid secretion) of human fetal lung explants. Reason: Indirect physiological response of fetal lung epithelium to FGFR2b stimulation; non-core (same treatment as FGF7). Supporting Evidence: PMID:10541313 First trimester fetal lung explants developed dose-dependent increases in intraluminal volume in response to KGF and FGF-10. |
| GO:0070075 tear secretion | IMP PMID:19102732 An intronic alteration of the fibroblast growth factor 10 ge... | MARK AS OVER ANNOTATED | Summary: ALSG patients with FGF10 mutations have lacrimal aplasia and irritable eyes. Reason: Tear-production defects are a secondary consequence of lacrimal gland/punctum aplasia; FGF10 does not execute tear secretion. The primary role is captured by lacrimal gland development. Supporting Evidence: PMID:19102732 Recent studies and our findings suggest that changed FGF10 signaling due to haploinsufficiency during development results in ALSG. PMID:19102732 Affected patients suffer from irritable eyes, epiphora (constant tearing) and xerostomia (dryness of the mouth) |
| GO:0070371 ERK1 and ERK2 cascade | IDA PMID:17959718 Heparanase cleavage of perlecan heparan sulfate modulates FG... | MODIFY | Summary: FGF10 release by heparanase increases MAPK signalling in submandibular gland epithelium. Reason: FGF10 is the extracellular ligand that activates the ERK1/2 cascade through FGFR2b; it does not participate in the kinase cascade itself. Positive regulation of ERK1 and ERK2 cascade (GO:0070374) is the appropriate representation. Proposed replacements: positive regulation of ERK1 and ERK2 cascade Supporting Evidence: PMID:17959718 heparanase releases FGF10 from perlecan HS in the basement membrane, increasing MAPK signaling, epithelial clefting, and lateral branch formation, which results in increased branching morphogenesis |
| GO:0071338 positive regulation of hair follicle cell proliferation | IDA PMID:16086254 Stimulation of human hair growth by the recombinant human ke... | KEEP AS NON CORE | Summary: Recombinant FGF10 (10 ng/ml) stimulated human hair-follicle cell proliferation in organ culture. Reason: Pharmacological effect on an FGFR2b-expressing epithelium; consistent with FGF10's mitogenic activity but not a core role. Supporting Evidence: PMID:16086254 significantly stimulated human hair-follicle cell proliferation in organ culture |
| GO:1900087 positive regulation of G1/S transition of mitotic cell cycle | IDA PMID:17188682 Fibroblast growth factor-10 prevents H2O2-induced cell cycle... | KEEP AS NON CORE | Summary: FGF10 prevents H2O2-induced G1 arrest of alveolar epithelial cells by maintaining G1 cyclins/CDKs. Reason: A downstream cell-cycle consequence of mitogenic FGFR signalling in stressed cells; non-core. Supporting Evidence: PMID:17188682 FGF-10 prevented H2O2-induced AEC G1 arrest. |
Loading supporting content…
Download this section (compressed HTML)Q: Should FGF10 also carry type 1 FGF receptor binding (GO:0005105), given mitogenesis-based evidence that it activates FGFR1b as well as FGFR2b, and how physiologically important is FGFR1b signalling for FGF10 in vivo?
Q: Is nuclear accumulation of internalized FGF10 (reported for recombinant protein in urothelial cells) physiologically relevant, and does it occur with endogenous FGF10 at physiological concentrations?
Q: Was the lymphocyte proliferation annotation from PMID:19152659 based on BaF3 FGFR2IIIb reporter cells, in which case it reflects the assay cell line rather than an FGF10 function?
Q: Should the FGF-family PAINT node for cytoplasm (PTN000160075) be restricted so it does not propagate to classically secreted, signal-peptide-bearing FGFs such as FGF7 and FGF10?
Experiment: Quantify FGF10 binding and signalling (pFRS2, pERK) across FGFR1-4 IIIb/IIIc isoforms with defined heparan sulfate and dermatan sulfate oligosaccharides and FGFBP1 in isogenic cells.
Hypothesis: FGF10 signalling is restricted to FGFR2b and FGFR1b and is tuned by glycosaminoglycan structure and FGFBP1.
Type: biochemistry/quantitative signaling
Experiment: Knock out FGF10 in human fetal lung or salivary mesenchyme co-cultured with epithelial organoids, and test rescue with wild-type versus ALSG/LADD missense FGF10 proteins.
Hypothesis: Mesenchymal FGF10 dosage is limiting for human epithelial bud outgrowth, and ALSG missense variants are loss-of-function.
Type: genome editing/organoid co-culture
Loading supporting content…
Download this section (compressed HTML)Loading supporting content…
Download this section (compressed HTML)Loading supporting content…
Download this section (compressed HTML)