Fibroblast growth factor 2 (basic FGF) is a heparin-binding member of the paracrine FGF family with a beta-trefoil fold. The 18 kDa AUG-initiated form lacks a signal peptide and is exported by unconventional secretion, translocating directly across the plasma membrane in a PI(4,5)P2- and heparan sulfate proteoglycan-dependent manner. Extracellular FGF2 is stored on heparan sulfate in the cell surface and extracellular matrix and binds FGFR1-FGFR4 (preferring the IIIc splice forms of FGFR1 and FGFR2), forming 2:2:2 FGF2-FGFR-heparan sulfate complexes that dimerize and activate the receptor tyrosine kinases, driving FRS2-RAS-MAPK, PI3K-AKT and PLCgamma signaling. These signals make FGF2 a potent mitogen, chemotactic and survival factor for endothelial, mesenchymal, neural and other cells, contributing to angiogenesis, wound healing and cortical neurogenesis; knockout mice are viable but show reduced cortical neuron density and delayed wound healing. CUG-initiated high-molecular-weight isoforms are retained intracellularly and localize to the nucleus, and internalized FGF2 can also reach the nucleus via CEP57 and importins; these intracrine activities are less well defined.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001658 branching involved in ureteric bud morphogenesis | IDA PMID:12631064 Evidence that bone morphogenetic protein 4 has multiple biol... | KEEP AS NON CORE | Summary: FGF2 was supplied to metanephric explants in a study of BMP4 function; FGF2 supports metanephric mesenchyme and ureteric bud growth in culture. Reason: Curator-made annotation from an explant study focused on BMP4 (abstract only available). FGF2 as an exogenous inductive growth factor in kidney explants is plausible, but branching morphogenesis is a tissue-level developmental outcome, not the core ligand activity; Fgf2 knockout mice have no reported kidney branching defect. Supporting Evidence: PMID:12631064 BMP4 uniformly promoted the expansion of the Pax2-negative and weakly Foxd1 (previously Bf2) -positive peripheral stromal compartment of metanephric mesenchyme in the presence of fibroblast growth factor 2 (FGF2) |
| GO:0001658 branching involved in ureteric bud morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ARBA machine-learning propagation of ureteric bud branching to FGF2. Reason: Electronic annotation consistent with FGF-family roles in ureteric bud branching; retained only as a non-core developmental context. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0001938 positive regulation of endothelial cell proliferation | IDA PMID:16756958 Fibroblast growth factor 16 and 18 are expressed in human ca... | KEEP AS NON CORE | Summary: FGF2 is a classical endothelial mitogen acting through FGFR1 on endothelial cells. Reason: Well supported (FGF2 is mitogenic on endothelial cells) but this is a cell-type-specific proliferative outcome of FGFR signaling, not a distinct activity of FGF2. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:0001938 positive regulation of endothelial cell proliferation | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: FGF2 is a classical endothelial mitogen acting through FGFR1 on endothelial cells. Reason: Well supported (FGF2 is mitogenic on endothelial cells) but this is a cell-type-specific proliferative outcome of FGFR signaling, not a distinct activity of FGF2. Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:0001938 positive regulation of endothelial cell proliferation | IMP PMID:18059339 The zinc-finger transcription factor, early growth response ... | KEEP AS NON CORE | Summary: FGF2 is a classical endothelial mitogen acting through FGFR1 on endothelial cells. Reason: Well supported (FGF2 is mitogenic on endothelial cells) but this is a cell-type-specific proliferative outcome of FGFR signaling, not a distinct activity of FGF2. The cited paper (abstract only) concerns VEGF/Egr3; FGF2 was presumably used as a comparator stimulus in the full text, so the curator's call is deferred to. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:0002042 cell migration involved in sprouting angiogenesis | IDA PMID:18059339 The zinc-finger transcription factor, early growth response ... | KEEP AS NON CORE | Summary: FGF2 stimulates endothelial cell migration during sprouting in vitro. Reason: FGF2 is not itself a migrating cell component; it is the extracellular cue. The annotation reflects a downstream endothelial response in an angiogenesis assay (abstract of PMID:18059339 concerns VEGF/Egr3; FGF2 data are in the full text). Retained as non-core. Supporting Evidence: PMID:20011604 the PI3K/PLC c1 pathway is involved in FGF-2-dependent cell migration |
| GO:0002042 cell migration involved in sprouting angiogenesis | IGI PMID:19351956 HDAC5 is a repressor of angiogenesis and determines the angi... | KEEP AS NON CORE | Summary: HDAC5 represses FGF2; FGF2 antagonism reduced sprouting caused by HDAC5 knockdown. Reason: Supports FGF2 as a paracrine pro-angiogenic cue for endothelial sprouting; downstream endothelial outcome, not core ligand activity. Supporting Evidence: PMID:19351956 Antagonization of FGF2 or Slit2 reduced sprout induction in response to HDAC5 siRNA. |
| GO:0005104 fibroblast growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: PAINT IBA: FGFR binding inherited across the paracrine FGF clade, with human FGF2 among the experimentally grounded members. Reason: FGFR binding is the defining molecular function of FGF2, supported by multiple ligand-receptor crystal structures and receptor-specific mitogenic assays. The appearance of P09038 among the IBA sources reflects its own experimental grounding. Supporting Evidence: PMID:10490103 Two FGF2:FGFR1 complexes form a 2-fold symmetric dimer. PMID:10830168 we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005104 fibroblast growth factor receptor binding | IEA GO_REF:0000120 | ACCEPT | Summary: Combined IEA for FGFR binding. Reason: Consistent with direct structural and biochemical evidence for FGF2 binding to FGFR1-4. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 PMID:10490103 Two FGF2:FGFR1 complexes form a 2-fold symmetric dimer. |
| GO:0005104 fibroblast growth factor receptor binding | IPI PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the dete... | ACCEPT | Summary: Crystal structure of FGF2 in complex with the FGFR2 D2-D3 ligand-binding domain. Reason: Direct structural evidence for FGF2-FGFR2 binding; core MF. Supporting Evidence: PMID:10830168 we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively |
| GO:0005104 fibroblast growth factor receptor binding | IPI PMID:2161540 A murine fibroblast growth factor (FGF) receptor expressed i... | ACCEPT | Summary: Mouse FGFR1 (P16092) expressed in receptor-negative CHO cells binds bFGF, is phosphorylated and drives DNA synthesis and proliferation. Reason: Direct binding and functional receptor activation; core MF. Supporting Evidence: PMID:2161540 We show that cells expressing the receptor can bind both basic FGF and Kaposi FGF. PMID:2161540 The receptor is phosphorylated upon stimulation with both FGFs, DNA synthesis is stimulated, and a proliferative response is produced in cells expressing the receptor |
| GO:0005125 cytokine activity | IDA PMID:18059339 The zinc-finger transcription factor, early growth response ... | MODIFY | Summary: Cytokine activity asserted for FGF2 from a VEGF/Egr3 endothelial study. Reason: FGF2 is extracellular signaling ligand, but 'growth factor activity' (and more specifically FGFR binding) is the conventional and more informative MF for FGF ligands; cytokine activity is typically reserved for immune-system cytokines. The source abstract concerns VEGF; the finding (FGF2 as positive control stimulus) is not disputed, only the term choice. Proposed replacements: growth factor activity Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in |
| GO:0005178 integrin binding | IDA PMID:28302677 The integrin-binding defective FGF2 mutants potently suppres... | ACCEPT | Summary: FGF2 binds integrin alphaVbeta3; integrin-binding-defective FGF2 mutants (K119E/R120E, K125E) are signaling-defective and dominant-negative. Reason: Full-text evidence of direct integrin binding with mutational support; accepted as a genuine but secondary (non-FGFR) binding activity. It is not made a core function because the model that integrin binding is required for FGF2 signaling rests largely on one laboratory's work. Supporting Evidence: PMID:28302677 Previous studies found that FGF2 bound to Ξ±vΞ²3 and antagonists to Ξ±vΞ²3 suppressed FGF2-induced angiogenesis. PMID:28302677 substituting Lys-119/Arg-120 and Lys-125 residues in the predicted integrin-binding interface of FGF2 to glutamic acid (the K119E/R120E and K125E mutations) effectively reduced integrin binding to FGF2 file:human/FGF2/FGF2-uniprot.txt Binds to integrin ITGAV:ITGB3 |
| GO:0005515 protein binding | IPI PMID:10490103 Structural basis for FGF receptor dimerization and activatio... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:10490103). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:10490103 Two FGF2:FGFR1 complexes form a 2-fold symmetric dimer. PMID:10490103 Within each complex, FGF2 interacts extensively with D2 and D3 as well as with the linker between the two domains. |
| GO:0005515 protein binding | IPI PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the dete... | MODIFY | Summary: Physical interaction of FGF2 with FGFR2 (PMID:10830168). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:10830168 we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively |
| GO:0005515 protein binding | IPI PMID:11030354 Crystal structure of a ternary FGF-FGFR-heparin complex reve... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:11030354). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:11030354 heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding |
| GO:0005515 protein binding | IPI PMID:11075807 FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor],... | REMOVE | Summary: FGF2 physically interacts with API5/FIF, a nuclear HMW-FGF2 partner of unknown molecular consequence. Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:11075807 we have isolated a gene encoding a nuclear protein of 55 kDa, FIF (FGF-2-interacting-factor), which interacts specifically with FGF-2 but not with FGF-1, FGF-3, or FGF-6 |
| GO:0005515 protein binding | IPI PMID:11390973 Structural basis for fibroblast growth factor receptor 2 act... | MODIFY | Summary: Physical interaction of FGF2 with FGFR2 (PMID:11390973). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:11390973 we determined the crystal structures of these two FGFR2 mutants in complex with fibroblast growth factor 2 (FGF2) |
| GO:0005515 protein binding | IPI PMID:11716516 Fibroblast growth factor-2 interacts with free ribosomal pro... | REMOVE | Summary: FGF2 physically interacts with free ribosomal protein RPS19, a cytoplasmic partner of internalized FGF2. Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:11716516 We showed that FGF-2 interacts directly with RPS19 in vitro. |
| GO:0005515 protein binding | IPI PMID:12717444 Translokin is an intracellular mediator of FGF-2 trafficking... | REMOVE | Summary: FGF2 physically interacts with CEP57/Translokin, a cytoplasmic trafficking partner required for nuclear translocation of internalized FGF2. Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:12717444 Translokin, a cytoplasmic protein of relative molecular mass 55,000 (M(r) 55K), interacts specifically with the 18K form of FGF-2 |
| GO:0005515 protein binding | IPI PMID:14613973 Proline to arginine mutations in FGF receptors 1 and 3 resul... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:14613973). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:14613973 The crystal structure, of Pro252Arg FGFR1c in complex with FGF2, demonstrates that the enhanced ligand binding is due to an additional set of receptor-ligand hydrogen bonds |
| GO:0005515 protein binding | IPI PMID:16257968 Identification of the fibroblast growth factor (FGF)-interac... | REMOVE | Summary: FGF2 physically interacts with FGFBP1, a secreted carrier that mobilizes FGF2 from matrix stores. Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:16257968 Fibroblast growth factor-binding proteins (FGF-BP) are secreted carrier proteins that release fibroblast growth factors (FGFs) from the extracellular matrix storage and thus enhance FGF activity. |
| GO:0005515 protein binding | IPI PMID:17086194 Klotho converts canonical FGF receptor into a specific recep... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (isoform IIIc) (PMID:17086194). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. The cited paper (abstract only for FGF2 details) used FGF2 with FGFR1 in binding/signaling assays; the interaction is well established. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:18329368 Active caspase-1 is a regulator of unconventional protein se... | REMOVE | Summary: FGF2 physically interacts with caspase-1, a regulator of unconventional FGF2 secretion (FGF2 is not a caspase-1 substrate). Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:18329368 Here we show that secretion of the leaderless proteins proIL-1alpha, caspase-1, and fibroblast growth factor (FGF)-2 depends on caspase-1 activity. |
| GO:0005515 protein binding | IPI PMID:20363749 The angiogenic inhibitor long pentraxin PTX3 forms an asymme... | REMOVE | Summary: FGF2 physically interacts with PTX3, a soluble FGF2 trap that inhibits FGF2-driven angiogenesis. Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:20363749 it inhibits FGF2 (fibroblast growth factor 2)-mediated angiogenesis |
| GO:0005515 protein binding | IPI PMID:22267482 Long pentraxin 3/tumor necrosis factor-stimulated gene-6 int... | REMOVE | Summary: FGF2 physically interacts with PTX3, a soluble FGF2 trap that inhibits FGF2-driven angiogenesis. Reason: Generic protein binding is uninformative. The interaction is real and biologically meaningful, but from the FGF2 side there is no specific molecular-function term that captures it (the partner regulates FGF2 rather than FGF2 performing an activity on it). Removal does not dispute the interaction. Supporting Evidence: PMID:22267482 Fibroblast growth factor 2 (FGF2) is a major proangiogenic inducer inhibited by the interaction with the soluble pattern recognition receptor long pentraxin 3 (PTX3). |
| GO:0005515 protein binding | IPI PMID:23597562 Inhibition of tumor angiogenesis and growth by a small-molec... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:23597562). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. The cited paper (abstract only for FGF2 details) used FGF2 with FGFR1 in binding/signaling assays; the interaction is well established. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:23597563 Molecular mechanism of SSR128129E, an extracellularly acting... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:23597563). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. The cited paper (abstract only for FGF2 details) used FGF2 with FGFR1 in binding/signaling assays; the interaction is well established. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:26267536 Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:26267536). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. The cited paper (abstract only for FGF2 details) used FGF2 with FGFR1 in binding/signaling assays; the interaction is well established. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: Physical interaction of FGF2 with FGFR2 (PMID:33961781). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Evidence here is from a high-throughput interactome screen, consistent with the extensive low-throughput structural data. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | MODIFY | Summary: Physical interaction of FGF2 with FGFR1 (PMID:35384245). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Evidence here is from a high-throughput interactome screen, consistent with the extensive low-throughput structural data. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | MODIFY | Summary: Physical interaction of FGF2 with FGFR2 (PMID:35384245). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Evidence here is from a high-throughput interactome screen, consistent with the extensive low-throughput structural data. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0005515 protein binding | IPI PMID:9700203 Apert syndrome mutations in fibroblast growth factor recepto... | MODIFY | Summary: Physical interaction of FGF2 with FGFR2 (PMID:9700203). Reason: The interacting partner is an FGF receptor, so the generic protein binding term should be replaced by the informative MF fibroblast growth factor receptor binding. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:9700203 Wild-type and Apert-type receptors form a complex with FGF ligands with a stoichiometry of 2:2 (ligand:receptor). |
| GO:0005576 extracellular region | EXP PMID:20230531 Tec-kinase-mediated phosphorylation of fibroblast growth fac... | ACCEPT | Summary: FGF2 is exported by unconventional, ER/Golgi-independent secretion and acts extracellularly. Reason: Direct experimental evidence of extracellular FGF2; the extracellular region is where the core FGFR-ligand activity occurs. Supporting Evidence: PMID:20230531 Fibroblast growth factor 2 (FGF2) is a potent mitogen that is exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | IBA GO_REF:0000033 | ACCEPT | Summary: IBA extracellular region for the FGF family. Reason: Correct for the secreted 18 kDa form of FGF2. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Fibroblast growth factor 2 (FGF2) is a potent mitogen that is exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. |
| GO:0005576 extracellular region | IDA PMID:2161540 A murine fibroblast growth factor (FGF) receptor expressed i... | ACCEPT | Summary: Extracellular bFGF binds and activates FGFR1 on transfected CHO cells. Reason: Exogenous FGF2 acts from the extracellular space. Supporting Evidence: PMID:2161540 We show that cells expressing the receptor can bind both basic FGF and Kaposi FGF. file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | IEA GO_REF:0000120 | ACCEPT | Summary: Combined IEA extracellular region. Reason: Consistent with experimental secretion data. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | TAS PMID:10490103 Structural basis for FGF receptor dimerization and activatio... | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (PMID:10490103). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: PMID:10490103 Two FGF2:FGFR1 complexes form a 2-fold symmetric dimer. file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | TAS PMID:2435575 Cloning and expression of cDNA encoding human basic fibrobla... | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (PMID:2435575). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: PMID:2435575 Transfection of the cDNA to COS cells resulted in the detection of mitogenic activity in the culture medium of the transfected cells file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-109699). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1839094 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-1839094). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1839098 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-1839098). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1839100 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-1839100). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190245 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190245). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190256 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190256). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190258 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190258). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190261 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190261). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190265 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190265). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190326 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190326). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190388 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190388). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190413 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190413). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190427 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190427). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190429 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-190429). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2012073 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2012073). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2012074 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2012074). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2023451 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2023451). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2023455 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2023455). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033472 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2033472). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033474 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2033474). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033486 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2033486). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033488 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2033488). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077420 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2077420). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077421 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2077421). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077424 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2077424). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2316434). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2396337 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2396337). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2400009). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2684507 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-2684507). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-480515 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-480515). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654147 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654147). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654148 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654148). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654149 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654149). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654151 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654151). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654157 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654157). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654159 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654159). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654163 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654163). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654165 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654165). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654167 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654167). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654169 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654169). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654222 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654222). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654224 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654224). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654392). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654397 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654397). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654399 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654399). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654402). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654404 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654404). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654406). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654407 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654407). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654408 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654408). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654409 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654409). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654413 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654413). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654416 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654416). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654418 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654418). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654422 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654422). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654423 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654423). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654425 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654425). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654426 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654426). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654428 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654428). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654560 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654560). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654562 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654562). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654565 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654565). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654566 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654566). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654569 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654569). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654571 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654571). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654573 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654573). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654575 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654575). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654578 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654578). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654582 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654582). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654584 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654584). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654586). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654587 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654587). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654591 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654591). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654592 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654592). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654594 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654594). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654596 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654596). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654597 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654597). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654600 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654600). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654603 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654603). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654605 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654605). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654607 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654607). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654608 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654608). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654612). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654614). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654615). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654618). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654620). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654622). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654623 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654623). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654625 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654625). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654628 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654628). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654631 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654631). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654633 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654633). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654634 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654634). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654637 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654637). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654640 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654640). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654641 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654641). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654643 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654643). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654646 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654646). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654647 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654647). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654651 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654651). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654653 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654653). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654655 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654655). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654658 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654658). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654659 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654659). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654662 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654662). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654663 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654663). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654664 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654664). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654667 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654667). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654669 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654669). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654672 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654672). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654673 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654673). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654677). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654679 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654679). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654684 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654684). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654690 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654690). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654692 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654692). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654697). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654701). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654705 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654705). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654709 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654709). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654714 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654714). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654717 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654717). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654729). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654730 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654730). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654734 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654734). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654748 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5654748). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655233). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655240 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655240). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655241). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655243 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655243). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655244 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655244). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655245). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655247 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655247). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655262 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655262). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655263 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655263). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655266 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655266). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655268 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655268). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655269 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655269). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655270 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655270). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655277 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655277). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655278 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655278). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655285 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655285). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655289 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655289). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655290 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655290). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655295 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655295). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655301 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655301). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655315 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655315). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655320). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655323). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655326 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655326). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655339 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655339). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655343 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5655343). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5656064 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5656064). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5656070 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5656070). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-5672965). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-6789615 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-6789615). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9839379 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-9839379). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-9839381 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-HSA-9839381). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005576 extracellular region | TAS Reactome:R-NUL-8853328 | ACCEPT | Summary: Reactome/TAS extracellular location for FGF2 in FGF-FGFR ligand-binding and downstream signaling reaction context (Reactome:R-NUL-8853328). Reason: FGF2 engages FGFRs and heparan sulfate proteoglycans in the extracellular region; the location is correct and experimentally supported (unconventional secretion). Redundant rows reflect distinct Reactome reactions. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt SUBCELLULAR LOCATION: Secreted PMID:20230531 Unconventional secretion of FGF2 occurs by direct translocation across plasma membranes |
| GO:0005634 nucleus | EXP PMID:22321063 Nuclear import of exogenous FGF1 requires the ER-protein LRR... | ACCEPT | Summary: Exogenous FGF2 is imported into the nucleus via CEP57/Translokin and importins alpha1/beta1; HMW isoforms are constitutively nuclear. Reason: Nuclear localization is well documented for both internalized 18 kDa FGF2 and the HMW isoforms; a genuine second location, though its molecular function there is poorly defined. Supporting Evidence: PMID:22321063 Nuclear import of exogenous FGF2, which depends on CEP57/Translokin, was independent of LRRC59, but was dependent on KpnΞ±1 and KpnΞ²1 file:human/FGF2/FGF2-uniprot.txt from the cytosol requires the classical nuclear import machinery |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: IBA nucleus (is_active_in) from FGF1/FGF2 node. Reason: FGF1 and FGF2 both reach the nucleus; supported by FGF2's own experimental data (P09038 is a source). Supporting Evidence: PMID:22321063 Nuclear import of exogenous FGF2, which depends on CEP57/Translokin, was independent of LRRC59, but was dependent on KpnΞ±1 and KpnΞ²1 PMID:11075807 three high molecular mass (HMM) nuclear forms of FGF-2 are part of a 320-kDa protein complex while the cytoplasmic AUG-initiated form is included in a 130-kDa complex |
| GO:0005634 nucleus | IEA GO_REF:0000044 | ACCEPT | Summary: UniProt subcellular-location mapping to nucleus. Reason: Consistent with experimental data. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt from the cytosol requires the classical nuclear import machinery |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: HPA immunofluorescence: nucleoplasm. Reason: Consistent with nuclear HMW FGF2 isoforms and nuclear import of FGF2. Supporting Evidence: PMID:11075807 three high molecular mass (HMM) nuclear forms of FGF-2 are part of a 320-kDa protein complex while the cytoplasmic AUG-initiated form is included in a 130-kDa complex |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: IBA cytoplasm (is_active_in). Reason: Unlike signal-peptide FGFs, FGF2 lacks a signal sequence and the 18 kDa form is synthesized and resides in the cytosol before unconventional export; internalized FGF2 also traffics through the cytosol. The cytoplasmic location is therefore correct for FGF2, though not the site of its core ligand activity. Supporting Evidence: PMID:20230531 Fibroblast growth factor 2 (FGF2) is a potent mitogen that is exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. PMID:12717444 Translokin, a cytoplasmic protein of relative molecular mass 55,000 (M(r) 55K), interacts specifically with the 18K form of FGF-2 |
| GO:0006325 chromatin organization | IEA GO_REF:0000108 | UNDECIDED | Summary: Inferred from the rat-derived histone H3K9me2/3 reader activity IEA via inter-ontology link. Reason: Depends entirely on GO:0062072 transferred from rat Fgf2; the source experiment is not available here and no human evidence for FGF2 as a chromatin reader was found. Cannot adjudicate. |
| GO:0006935 chemotaxis | TAS PMID:10848592 Involvement of Ras and Ral in chemotactic migration of skele... | KEEP AS NON CORE | Summary: bFGF is a chemotactic cue for C2C12 myoblasts, acting via Ras/Ral. Reason: FGF2 elicits chemotaxis as an extracellular cue; a cellular outcome of FGFR signaling in myoblasts. Supporting Evidence: PMID:10848592 Expression of a dominant-negative mutant of Ras inhibited chemotaxis of C2C12 myoblasts in response to basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and insulin-like growth factor 1 (IGF-1) |
| GO:0007165 signal transduction | NAS PMID:9712850 Nerve growth factor regulation of m4 muscarinic receptor mRN... | MODIFY | Summary: bFGF upregulates m4 muscarinic receptor mRNA in PC12 cells via sustained MAPK. Reason: 'Signal transduction' is uninformatively broad for an FGFR ligand; the specific pathway FGF2 initiates is FGFR signaling. Proposed replacements: fibroblast growth factor receptor signaling pathway Supporting Evidence: PMID:9712850 Two other growth factors, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF), up-regulated m4 mRNA and mAChR binding sites. |
| GO:0007265 Ras protein signal transduction | TAS PMID:10848592 Involvement of Ras and Ral in chemotactic migration of skele... | KEEP AS NON CORE | Summary: bFGF activates Ras and Ral in C2C12 myoblasts. Reason: Ras activation is a canonical downstream consequence of FGFR engagement by FGF2 (via FRS2-GRB2-SOS); FGF2 acts upstream as ligand. Retained as non-core; the core process is the FGFR signaling pathway. Supporting Evidence: PMID:10848592 we found that Ras and Ral are activated in C2C12 cells by bFGF, HGF and IGF-1 |
| GO:0007399 nervous system development | TAS PMID:9576942 Neuronal defects and delayed wound healing in mice lacking f... | KEEP AS NON CORE | Summary: Fgf2-/- mice have reduced cortical neuron density. Reason: Supported by knockout phenotype; a developmental outcome, not the core activity. Supporting Evidence: PMID:9576942 A significant reduction in neuronal density is observed in most layers of the motor cortex in the FGF2(-/-) mice |
| GO:0008083 growth factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: IBA growth factor activity for paracrine FGFs. Reason: FGF2 is a prototypic growth factor; accepted alongside FGFR binding. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in PMID:8663044 We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. |
| GO:0008083 growth factor activity | IDA PMID:18059339 The zinc-finger transcription factor, early growth response ... | ACCEPT | Summary: Growth factor activity (IDA) from an endothelial VEGF/Egr3 study. Reason: Abstract concerns VEGF; FGF2 growth factor activity on endothelial cells is not in doubt and the curator's full-text reading is deferred to. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:0008083 growth factor activity | IDA PMID:26451614 MiR-573 inhibits prostate cancer metastasis by regulating ep... | ACCEPT | Summary: FGF2 activates FGFR1-dependent signaling in prostate cancer cells. Reason: Growth factor activity via FGFR1 is well supported. Supporting Evidence: PMID:26451614 miR-573 modulates the activation of FGFR1-downstream signaling in response to fibroblast growth factor 2 (FGF2) |
| GO:0008083 growth factor activity | IEA GO_REF:0000120 | ACCEPT | Summary: Combined IEA growth factor activity. Reason: Correct. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | ACCEPT | Summary: IBA positive regulation of cell population proliferation. Reason: Mitogenic activity is the defining classical output of FGF2 signaling through FGFRs (the protein was named for it); accepted at this general level. Supporting Evidence: PMID:8663044 We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. PMID:2161540 The receptor is phosphorylated upon stimulation with both FGFs, DNA synthesis is stimulated, and a proliferative response is produced in cells expressing the receptor |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:2161540 A murine fibroblast growth factor (FGF) receptor expressed i... | ACCEPT | Summary: bFGF stimulates DNA synthesis and proliferation of FGFR1-expressing CHO cells. Reason: Direct demonstration of FGF2-FGFR mitogenic signaling. Supporting Evidence: PMID:2161540 The receptor is phosphorylated upon stimulation with both FGFs, DNA synthesis is stimulated, and a proliferative response is produced in cells expressing the receptor |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000120 | ACCEPT | Summary: Combined IEA. Reason: Consistent with extensive mitogenic evidence. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: Mitogenic activity of FGF2 on FGFR1-expressing BaF3 cells (receptor specificity panel). Reason: Receptor-specific mitogenic assay; genuine. Supporting Evidence: PMID:8663044 we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors PMID:8663044 We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: Mitogenic activity of FGF2 on FGFR2-expressing BaF3 cells (receptor specificity panel). Reason: Receptor-specific mitogenic assay; genuine. Supporting Evidence: PMID:8663044 we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors PMID:8663044 We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. |
| GO:0008284 positive regulation of cell population proliferation | TAS PMID:2435575 Cloning and expression of cDNA encoding human basic fibrobla... | ACCEPT | Summary: Recombinant human bFGF cDNA expressed in COS cells yields mitogenic activity in culture medium. Reason: Traceable statement of mitogenic activity. Supporting Evidence: PMID:2435575 Transfection of the cDNA to COS cells resulted in the detection of mitogenic activity in the culture medium of the transfected cells |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: IBA FGFR signaling pathway. Reason: Core process: FGF2 initiates FGFR signaling as the ligand. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 PMID:2161540 The receptor is phosphorylated upon stimulation with both FGFs, DNA synthesis is stimulated, and a proliferative response is produced in cells expressing the receptor |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:16774925 The novel SPARC family member SMOC-2 potentiates angiogenic ... | ACCEPT | Summary: FGF2 synergizes with SMOC-2 in endothelial DNA synthesis and invasion. Reason: Consistent with FGF2 acting through FGFR signaling in endothelial cells (details in full text). Supporting Evidence: PMID:16774925 Overexpressed SMOC-2 also synergized with vascular endothelial growth factor or with basic fibroblast growth factor to stimulate DNA synthesis. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:17500071 Regulation of secreted Frizzled-related protein-1 by heparin... | ACCEPT | Summary: Heparin-induced sFRP-1 accumulation requires FGF2 and FGFR1. Reason: Supports an FGF2-FGFR1 signaling role. Supporting Evidence: PMID:17500071 The effect requires O-sulfation in heparin, and involves fibroblast growth factor-2 as well as fibroblast growth factor receptor-1. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:18059339 The zinc-finger transcription factor, early growth response ... | ACCEPT | Summary: FGFR signaling pathway (IDA) from an endothelial VEGF/Egr3 study. Reason: Abstract concerns VEGF; FGF2 was presumably a comparator stimulus. Defer to the curator; the process is core for FGF2. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | ACCEPT | Summary: FGF-2 activates PI3K and PLCgamma1 downstream of FGFR in HUVECs. Reason: Direct evidence of FGF2-initiated FGFR signaling. Supporting Evidence: PMID:20011604 We show that FGF-2 activates PLC c1 in HUVECs measured by analysis of total inositol phosphates production upon metabolic labelling of cells and intracellular calcium increase. PMID:20011604 We further demonstrate that FGF-2 activates PI3K |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | ACCEPT | Summary: bFGF-induced Akt activation and endothelial responses depend on p110delta. Reason: FGF2-initiated FGFR signaling in retinal endothelial cells. Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: ARBA IEA FGFR signaling pathway. Reason: Correct. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:2161540 A murine fibroblast growth factor (FGF) receptor expressed i... | ACCEPT | Summary: Mouse FGFR1 in CHO cells is activated by bFGF. Reason: acts_upstream_of_or_within qualifier is appropriate for the ligand; core process. Supporting Evidence: PMID:2161540 The receptor is phosphorylated upon stimulation with both FGFs, DNA synthesis is stimulated, and a proliferative response is produced in cells expressing the receptor |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:26451614 MiR-573 inhibits prostate cancer metastasis by regulating ep... | ACCEPT | Summary: miR-573 targets FGFR1 and modulates FGFR1-downstream signaling in response to FGF2. Reason: Supports FGF2-FGFR1 signaling. Supporting Evidence: PMID:26451614 miR-573 modulates the activation of FGFR1-downstream signaling in response to fibroblast growth factor 2 (FGF2) |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF2 activates FGFR1 splice variants in the Ornitz receptor-specificity panel. Reason: Core process. Supporting Evidence: PMID:8663044 we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF2 activates FGFR2 splice variants in the Ornitz receptor-specificity panel. Reason: Core process. Supporting Evidence: PMID:8663044 we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IPI PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the dete... | ACCEPT | Summary: FGF2-FGFR2 crystal structure. Reason: Structural basis for FGF2 initiating FGFR signaling. Supporting Evidence: PMID:10830168 we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively |
| GO:0009792 embryo development ending in birth or egg hatching | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Embryo development transferred from rat Fgf2 by Ensembl Compara. Reason: Fgf2 knockout mice lacking all isoforms are viable, fertile and grossly normal; FGF2 is not essential for embryonic development. This very broad term overstates FGF2's developmental role. Supporting Evidence: PMID:9576942 FGF2, although not essential for embryonic development, plays a specific role in cortical neurogenesis and skin wound healing in mice |
| GO:0009887 animal organ morphogenesis | TAS PMID:10903182 Signaling and transcriptional regulation in early mammalian ... | KEEP AS NON CORE | Summary: FGF signals from surface ectoderm specify neuroretina in the optic vesicle (FGF-coated beads). Reason: Developmental outcome of FGF signaling; the study used FGF beads rather than defining an FGF2-specific requirement. Supporting Evidence: PMID:10903182 The partitioning depends on extrinsic signals, notably fibroblast growth factors, which emanate from the overlying surface ectoderm and induce the adjacent neuroepithelium to assume the neuroretinal fate. |
| GO:0010595 positive regulation of endothelial cell migration | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: bFGF-induced endothelial migration depends on p110delta. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:0010629 negative regulation of gene expression | NAS PMID:24463821 Autoregulation of glypican-1 by intronic microRNA-149 fine t... | MARK AS OVER ANNOTATED | Summary: FGF2 induces miR-149, which represses GPC1 and FGFR1. Reason: 'Negative regulation of gene expression' is a vague, indirect consequence (via miRNA induction) of FGF2 signaling and adds little information. Supporting Evidence: PMID:24463821 FGF2 transcriptionally stimulated the expression of miR-149 independently of its host gene |
| GO:0010764 negative regulation of fibroblast migration | IDA PMID:19577615 bFGF induces changes in hyaluronan synthase and hyaluronidas... | KEEP AS NON CORE | Summary: bFGF decreases HT1080 fibrosarcoma cell migration by increasing pericellular high-molecular-weight hyaluronan. Reason: Cell-line-specific (not seen in B6FS cells) indirect effect via HA metabolism; retained as non-core. Supporting Evidence: PMID:19577615 bFGF regulates, in a cell-specific manner the migration capability of fibrosarcoma cells by modulating their HA metabolism. |
| GO:0014843 growth factor dependent regulation of skeletal muscle satellite cell proliferation | IMP PMID:18602469 The role of syndecan-4 and attached glycosaminoglycan chains... | KEEP AS NON CORE | Summary: FGF2 stimulates turkey satellite cell proliferation. Reason: FGF2 is a potent satellite-cell mitogen; a cell-type-specific proliferative outcome. Supporting Evidence: PMID:18602469 Fibroblast growth factor 2 is a potent stimulator of muscle proliferation and an intense inhibitor of differentiation. |
| GO:0016604 nuclear body | IDA GO_REF:0000052 | ACCEPT | Summary: HPA immunofluorescence: nuclear bodies. Reason: Consistent with nuclear HMW FGF2 residing in nuclear protein complexes. Supporting Evidence: PMID:11075807 three high molecular mass (HMM) nuclear forms of FGF-2 are part of a 320-kDa protein complex while the cytoplasmic AUG-initiated form is included in a 130-kDa complex |
| GO:0019956 chemokine binding | IPI PMID:11708770 The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endot... | KEEP AS NON CORE | Summary: CXCL13 binds FGF2 forming heterodimers and inhibits FGF2 activity on endothelial cells. Reason: Direct binding to a chemokine is reported and is a mechanism of FGF2 inhibition; accurate but not a core function. Supporting Evidence: PMID:11708770 CXCL13 displaces FGF-2 binding to endothelial cells, inhibits FGF-2 homodimerization, and induces the formation of CXCL13-FGF-2 heterodimers |
| GO:0022008 neurogenesis | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA neurogenesis. Reason: Supported by the cortical neuron deficit of Fgf2-/- mice; developmental outcome. Supporting Evidence: PMID:9576942 A significant reduction in neuronal density is observed in most layers of the motor cortex in the FGF2(-/-) mice |
| GO:0030214 hyaluronan catabolic process | IDA PMID:19577615 bFGF induces changes in hyaluronan synthase and hyaluronidas... | MARK AS OVER ANNOTATED | Summary: bFGF inhibits HA degradation by reducing HYAL2 expression in HT1080 cells. Reason: The cited abstract reports that bFGF inhibited hyaluronan degradation via reduced hyaluronidase-2 expression; FGF2 does not participate in HA catabolism and the observed effect is an indirect, cell-line-specific transcriptional one in the opposite direction. The term overstates FGF2's role; not removed because full text was not examined. Supporting Evidence: PMID:19577615 bFGF inhibited the degradation of HA by decreasing hyaluronidase-2 expression in HT1080 cells |
| GO:0030334 regulation of cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA regulation of cell migration. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:20011604 the PI3K/PLC c1 pathway is involved in FGF-2-dependent cell migration |
| GO:0038001 paracrine signaling | IEA GO_REF:0000107 | ACCEPT | Summary: Paracrine signaling (rat ortholog IEA). Reason: FGF2 is a paracrine (and autocrine) FGFR ligand. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0038001 paracrine signaling | ISS GO_REF:0000024 | ACCEPT | Summary: Paracrine signaling (ISS from rat). Reason: FGF2 is a paracrine ligand; correct. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway | NAS PMID:24463821 Autoregulation of glypican-1 by intronic microRNA-149 fine t... | KEEP AS NON CORE | Summary: FGF2 induces miR-149, which targets GPC1 and FGFR1, as a negative feedback on FGF2 responses. Reason: Feedback attenuation via miRNA is reported (acts_upstream_of); an indirect regulatory loop, not a core activity. Supporting Evidence: PMID:24463821 FGF2 transcriptionally stimulated the expression of miR-149 independently of its host gene PMID:24463821 both miR-149 and miR-149* regulated FGF2 signaling and FGF2-induced responses in ECs, namely proliferation, migration and cord formation |
| GO:0042056 chemoattractant activity | IDA PMID:18059339 The zinc-finger transcription factor, early growth response ... | KEEP AS NON CORE | Summary: Chemoattractant activity (IDA) from an endothelial VEGF/Egr3 study. Reason: FGF2 is a chemotactic cue for endothelial and other cells (acting via FGFR); acceptable as a non-core MF description. Abstract does not show FGF2 data; curator deferred to. Supporting Evidence: PMID:10848592 Expression of a dominant-negative mutant of Ras inhibited chemotaxis of C2C12 myoblasts in response to basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and insulin-like growth factor 1 (IGF-1) |
| GO:0042060 wound healing | IDA PMID:16756958 Fibroblast growth factor 16 and 18 are expressed in human ca... | KEEP AS NON CORE | Summary: Wound healing (IDA) from a paper on FGF16/FGF18 in endothelial cells. Reason: FGF2 contributes to skin wound healing in vivo (delayed healing in knockout); the cited study used an in vitro endothelial mechanical-damage assay. Non-core outcome. Supporting Evidence: PMID:9576942 the healing of excisional skin wounds is delayed in mice lacking FGF2 PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:0042060 wound healing | TAS PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | KEEP AS NON CORE | Summary: Wound healing (TAS). Reason: Supported by delayed wound healing of Fgf2-/- mice; tissue-level outcome. Supporting Evidence: PMID:9576942 the healing of excisional skin wounds is delayed in mice lacking FGF2 |
| GO:0042660 positive regulation of cell fate specification | IDA PMID:18635606 Crucial role of vHNF1 in vertebrate hepatic specification. | KEEP AS NON CORE | Summary: FGF-induced hepatic specification of ventral endoderm. Reason: FGF signalling from cardiac mesoderm induces hepatic fate; FGF2 used as the inductive ligand in explants. Developmental outcome. Supporting Evidence: PMID:18635606 mutant ventral endoderm cultured in vitro loses its responsiveness to inductive FGF signals and fails to induce the hepatic-specification genes albumin and transthyretin |
| GO:0042802 identical protein binding | IPI PMID:11708770 The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endot... | KEEP AS NON CORE | Summary: FGF2 homodimerization (inhibited by CXCL13). Reason: FGF2 forms homodimers and higher oligomers (relevant to unconventional secretion); accurate but not an informative core function. Supporting Evidence: PMID:11708770 CXCL13 displaces FGF-2 binding to endothelial cells, inhibits FGF-2 homodimerization, and induces the formation of CXCL13-FGF-2 heterodimers |
| GO:0043406 positive regulation of MAP kinase activity | IDA PMID:16756958 Fibroblast growth factor 16 and 18 are expressed in human ca... | ACCEPT | Summary: FGF2 induces sustained MAPK activation in endothelial cells and hepatocytes. Reason: Direct consequence of FGFR activation by FGF2; accepted (positive regulation of MAPK cascade is the parent used in the core function). Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: IBA positive regulation of MAPK cascade. Reason: Canonical FGFR-FRS2-RAS-MAPK output of FGF2. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types PMID:17167778 In all cell types, FGF treatment elevated endogenous ERK phosphorylation. |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:26451614 MiR-573 inhibits prostate cancer metastasis by regulating ep... | ACCEPT | Summary: FGF2-induced FGFR1 downstream signaling in PCa cells. Reason: Consistent with canonical output. Supporting Evidence: PMID:26451614 miR-573 modulates the activation of FGFR1-downstream signaling in response to fibroblast growth factor 2 (FGF2) |
| GO:0043410 positive regulation of MAPK cascade | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | ACCEPT | Summary: bFGF signaling in retinal endothelial cells. Reason: Consistent with canonical FGFR outputs (details in full text). Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:0043536 positive regulation of blood vessel endothelial cell migration | IDA PMID:18555217 Differential involvement of TGF-beta1 in mediating the motog... | KEEP AS NON CORE | Summary: FGF2 stimulates blood vessel endothelial cell migration. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:18555217 FGF-2-stimulated endothelial cell migration was either further stimulated or inhibited by TSP-1, following the same bi-phasic dose response as in the absence of FGF-2. |
| GO:0043536 positive regulation of blood vessel endothelial cell migration | IDA PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | KEEP AS NON CORE | Summary: FGF2 stimulates blood vessel endothelial cell migration. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:20011604 the PI3K/PLC c1 pathway is involved in FGF-2-dependent cell migration |
| GO:0043536 positive regulation of blood vessel endothelial cell migration | IDA PMID:28302677 The integrin-binding defective FGF2 mutants potently suppres... | KEEP AS NON CORE | Summary: FGF2 stimulates blood vessel endothelial cell migration. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:28302677 Previous studies found that FGF2 bound to Ξ±vΞ²3 and antagonists to Ξ±vΞ²3 suppressed FGF2-induced angiogenesis. |
| GO:0043536 positive regulation of blood vessel endothelial cell migration | IGI PMID:23263626 An endothelial apelin-FGF link mediated by miR-424 and miR-5... | KEEP AS NON CORE | Summary: FGF2 stimulates blood vessel endothelial cell migration. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:23263626 APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. |
| GO:0043537 negative regulation of blood vessel endothelial cell migration | IDA PMID:18555217 Differential involvement of TGF-beta1 in mediating the motog... | UNDECIDED | Summary: Negative regulation of endothelial migration attributed to FGF2 from a TSP-1 study. Reason: The abstract describes FGF-2 as the stimulus of endothelial migration and TSP-1 (via TGF-beta1) as the biphasic modulator; the basis for a negative-regulation annotation on FGF2 is not visible in the abstract and the full text is not available. The same paper supports the positive regulation annotation. Supporting Evidence: PMID:18555217 FGF-2-stimulated endothelial cell migration was either further stimulated or inhibited by TSP-1, following the same bi-phasic dose response as in the absence of FGF-2. |
| GO:0045471 response to ethanol | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Response to ethanol (rat ortholog IEA). Reason: Response-to-chemical annotations transferred from rat typically reflect expression changes, not a function of the FGF2 protein; source experiment not evaluated here. |
| GO:0045765 regulation of angiogenesis | TAS PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | KEEP AS NON CORE | Summary: Regulation of angiogenesis (TAS). Reason: FGF2 is a potent pro-angiogenic factor; tissue-level outcome of FGFR signaling in endothelium. Supporting Evidence: PMID:20011604 We show that FGF-2 activates PLC c1 in HUVECs measured by analysis of total inositol phosphates production upon metabolic labelling of cells and intracellular calcium increase. |
| GO:0045766 positive regulation of angiogenesis | IDA PMID:16774925 The novel SPARC family member SMOC-2 potentiates angiogenic ... | KEEP AS NON CORE | Summary: FGF2 promotes angiogenesis in endothelial assays. Reason: FGF2 is a classical angiogenic factor, but Fgf2-/- mice have no gross vascular defect; angiogenesis is a downstream, context-dependent outcome rather than the core ligand activity. Supporting Evidence: PMID:16774925 Basic fibroblast growth factor and SMOC-2 elicited a synergistic effect on cell invasion. file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:0045766 positive regulation of angiogenesis | IDA PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | KEEP AS NON CORE | Summary: FGF2 promotes angiogenesis in endothelial assays. Reason: FGF2 is a classical angiogenic factor, but Fgf2-/- mice have no gross vascular defect; angiogenesis is a downstream, context-dependent outcome rather than the core ligand activity. Supporting Evidence: PMID:20011604 the PI3K/PLC c1 pathway is involved in FGF-2-dependent cell migration file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:0045766 positive regulation of angiogenesis | IDA PMID:28302677 The integrin-binding defective FGF2 mutants potently suppres... | KEEP AS NON CORE | Summary: FGF2 promotes angiogenesis in endothelial assays. Reason: FGF2 is a classical angiogenic factor, but Fgf2-/- mice have no gross vascular defect; angiogenesis is a downstream, context-dependent outcome rather than the core ligand activity. Supporting Evidence: PMID:28302677 Previous studies found that FGF2 bound to Ξ±vΞ²3 and antagonists to Ξ±vΞ²3 suppressed FGF2-induced angiogenesis. file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:0045766 positive regulation of angiogenesis | IGI PMID:16774925 The novel SPARC family member SMOC-2 potentiates angiogenic ... | KEEP AS NON CORE | Summary: FGF2 promotes angiogenesis in endothelial assays. Reason: FGF2 is a classical angiogenic factor, but Fgf2-/- mice have no gross vascular defect; angiogenesis is a downstream, context-dependent outcome rather than the core ligand activity. Supporting Evidence: PMID:16774925 Overexpressed SMOC-2 also synergized with vascular endothelial growth factor or with basic fibroblast growth factor to stimulate DNA synthesis. file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:0045944 positive regulation of transcription by RNA polymerase II | IDA PMID:18059339 The zinc-finger transcription factor, early growth response ... | MARK AS OVER ANNOTATED | Summary: Positive regulation of transcription by RNA polymerase II (IDA) from a VEGF/Egr3 study. Reason: Induction of immediate-early gene transcription is a distal consequence of FGFR-MAPK signaling; FGF2 is an extracellular ligand and does not itself regulate transcription in this sense. Abstract concerns VEGF. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:0048149 behavioral response to ethanol | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Behavioral response to ethanol (rat ortholog IEA). Reason: Organism-level behavioral term transferred electronically from rat; not a function of FGF2 as a molecule and not evaluated in human. |
| GO:0048598 embryonic morphogenesis | TAS PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | MARK AS OVER ANNOTATED | Summary: Embryonic morphogenesis (TAS) from an endothelial tubulogenesis paper. Reason: The cited paper studies FGF-2-induced capillary tube formation in HUVECs, not embryonic morphogenesis; Fgf2-/- embryos develop normally. Supporting Evidence: PMID:9576942 FGF2, although not essential for embryonic development, plays a specific role in cortical neurogenesis and skin wound healing in mice |
| GO:0048661 positive regulation of smooth muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Positive regulation of smooth muscle cell proliferation (rat IEA). Reason: FGF2 is a smooth-muscle mitogen; cell-type-specific outcome. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in |
| GO:0048864 stem cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Stem cell development (mouse IEA). Reason: FGF2 supports stem/progenitor cell maintenance (e.g. hPSC self-renewal); context-specific outcome. Supporting Evidence: PMID:25640183 basic fibroblast growth factor (bFGF) signaling through mitogen-activated protein kinase (MAPK)/ERK amplifies canonical WNT signaling by phosphorylating LRP6, resulting in enhanced undifferentiated proliferation |
| GO:0050918 positive chemotaxis | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: Positive chemotaxis inferred from chemoattractant activity. Reason: FGF2 is a chemotactic cue; non-core outcome. Supporting Evidence: PMID:10848592 Expression of a dominant-negative mutant of Ras inhibited chemotaxis of C2C12 myoblasts in response to basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and insulin-like growth factor 1 (IGF-1) |
| GO:0051209 release of sequestered calcium ion into cytosol | IDA PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | KEEP AS NON CORE | Summary: FGF-2 triggers PLCgamma1 activation and intracellular calcium increase in HUVECs. Reason: A downstream second-messenger event of FGFR-PLCgamma signaling; FGF2 acts as upstream ligand. Supporting Evidence: PMID:20011604 We show that FGF-2 activates PLC c1 in HUVECs measured by analysis of total inositol phosphates production upon metabolic labelling of cells and intracellular calcium increase. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:20011604 A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway re... | ACCEPT | Summary: FGF2 activates PI3K-Akt signaling downstream of FGFR. Reason: PI3K/Akt activation (via FRS2-GAB1) is a canonical direct output of FGF2-FGFR engagement; accepted. Supporting Evidence: PMID:20011604 We further demonstrate that FGF-2 activates PI3K |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:26451614 MiR-573 inhibits prostate cancer metastasis by regulating ep... | ACCEPT | Summary: FGF2 activates PI3K-Akt signaling downstream of FGFR. Reason: PI3K/Akt activation (via FRS2-GAB1) is a canonical direct output of FGF2-FGFR engagement; accepted. Supporting Evidence: PMID:26451614 miR-573 modulates the activation of FGFR1-downstream signaling in response to fibroblast growth factor 2 (FGF2) |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | ACCEPT | Summary: FGF2 activates PI3K-Akt signaling downstream of FGFR. Reason: PI3K/Akt activation (via FRS2-GAB1) is a canonical direct output of FGF2-FGFR engagement; accepted. Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IGI PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | ACCEPT | Summary: FGF2 activates PI3K-Akt signaling downstream of FGFR. Reason: PI3K/Akt activation (via FRS2-GAB1) is a canonical direct output of FGF2-FGFR engagement; accepted. Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:0060045 positive regulation of cardiac muscle cell proliferation | IDA PMID:9553078 Neuregulins promote survival and growth of cardiac myocytes.... | KEEP AS NON CORE | Summary: Cardiac myocyte proliferation (IDA) from a neuregulin study. Reason: FGF2 is a known cardiomyocyte mitogen, presumably used as comparator in the full text; cell-type-specific outcome. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in |
| GO:0060045 positive regulation of cardiac muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cardiac myocyte proliferation (rat IEA). Reason: Cell-type-specific mitogenic outcome. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Functions as a potent mitogen in |
| GO:0060591 chondroblast differentiation | IDA PMID:17167778 Fibroblast growth factors 2, 4, and 8 exert both negative an... | KEEP AS NON CORE | Summary: FGF2 modulates chondrogenesis of chick limb/facial mesenchyme via MEK-ERK. Reason: FGF2 has both inhibitory and stimulatory effects depending on tissue; a context-dependent outcome of FGFR-ERK signaling. Supporting Evidence: PMID:17167778 FGF8, 4, and 2 treatments exert both inhibitory and stimulatory effects on cartilage differentiation |
| GO:0060978 angiogenesis involved in coronary vascular morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Coronary angiogenesis (rat IEA). Reason: Plausible tissue-specific angiogenic context; non-core. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:0061045 negative regulation of wound healing | IDA PMID:19577615 bFGF induces changes in hyaluronan synthase and hyaluronidas... | MODIFY | Summary: Negative regulation of wound healing from an in vitro scratch ('wound healing') migration assay of fibrosarcoma cells. Reason: The assay measures cell migration into a scratch, not tissue wound healing; in vivo FGF2 promotes wound healing (delayed healing in knockouts). The finding is better captured as reduced fibroblast-like cell migration. Proposed replacements: negative regulation of fibroblast migration Supporting Evidence: PMID:19577615 bFGF regulates, in a cell-specific manner the migration capability of fibrosarcoma cells by modulating their HA metabolism. PMID:9576942 the healing of excisional skin wounds is delayed in mice lacking FGF2 |
| GO:0062072 histone H3K9me2/3 reader activity | IEA GO_REF:0000107 | UNDECIDED | Summary: Histone H3K9me2/3 reader activity transferred electronically from rat Fgf2. Reason: No human evidence found for FGF2 acting as a histone methyl-lysine reader; the rat source experiment was not available for review. FGF2 lacks known reader domains (it is a beta-trefoil growth factor), so the claim needs verification before acceptance. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IDA PMID:17167778 Fibroblast growth factors 2, 4, and 8 exert both negative an... | ACCEPT | Summary: FGF2 elevates ERK phosphorylation in chick mesenchyme. Reason: Canonical FGFR-MEK-ERK output of FGF2. Supporting Evidence: PMID:17167778 In all cell types, FGF treatment elevated endogenous ERK phosphorylation. |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IEA GO_REF:0000107 | ACCEPT | Summary: Positive regulation of ERK1/ERK2 cascade (rat IEA). Reason: Canonical output. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:0071260 cellular response to mechanical stimulus | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Cellular response to mechanical stimulus (rat IEA). Reason: Likely reflects mechanically induced FGF2 expression/release in rat tissue; describes regulation of the gene rather than a function of the protein. |
| GO:0072089 stem cell proliferation | NAS PMID:25640183 Functional consequences of 17q21.31/WNT3-WNT9B amplification... | MODIFY | Summary: bFGF-MAPK/ERK signaling enhances undifferentiated proliferation of hPSCs. Reason: FGF2 is an extracellular mitogen for stem cells; it regulates rather than participates in stem cell proliferation, so the positive regulation term is more accurate. Proposed replacements: positive regulation of stem cell proliferation Supporting Evidence: PMID:25640183 basic fibroblast growth factor (bFGF) signaling through mitogen-activated protein kinase (MAPK)/ERK amplifies canonical WNT signaling by phosphorylating LRP6, resulting in enhanced undifferentiated proliferation |
| GO:0090049 regulation of cell migration involved in sprouting angiogenesis | NAS PMID:24463821 Autoregulation of glypican-1 by intronic microRNA-149 fine t... | KEEP AS NON CORE | Summary: FGF2-induced endothelial migration modulated by miR-149 feedback. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:24463821 both miR-149 and miR-149* regulated FGF2 signaling and FGF2-induced responses in ECs, namely proliferation, migration and cord formation |
| GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis | IDA PMID:28302677 The integrin-binding defective FGF2 mutants potently suppres... | KEEP AS NON CORE | Summary: FGF2 promotes endothelial migration in sprouting assays; integrin-binding mutants are antagonistic. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:28302677 Previous studies found that FGF2 bound to Ξ±vΞ²3 and antagonists to Ξ±vΞ²3 suppressed FGF2-induced angiogenesis. |
| GO:0090722 receptor-receptor interaction | IDA PMID:24157794 Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes.... | MODIFY | Summary: FGF2 treatment increased FGFR1 homodimerization within FGFR1-5-HT1A heteroreceptor complexes (BRET). Reason: Receptor-receptor interaction is an activity of the receptors (FGFR1 and 5-HT1A), not of the ligand. The FGF2 data show ligand-induced FGFR1 dimerization, which is FGF2's FGFR binding activity. Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:24157794 FGF2 produced a marked and rapid increase in FGFR1 homodimerization which partially declined over a 10min period. |
| GO:1902748 positive regulation of lens fiber cell differentiation | IDA PMID:29501879 Negative regulation of lens fiber cell differentiation by RT... | KEEP AS NON CORE | Summary: FGF drives ERK1/2 phosphorylation and lens fiber differentiation in lens epithelial explants. Reason: Well-established FGF role in lens; tissue-specific outcome. Supporting Evidence: PMID:29501879 FGF-induced lens fiber differentiation |
| GO:1902895 positive regulation of miRNA transcription | NAS PMID:24463821 Autoregulation of glypican-1 by intronic microRNA-149 fine t... | KEEP AS NON CORE | Summary: FGF2 transcriptionally stimulates miR-149. Reason: Indirect downstream transcriptional consequence of FGF2 signaling. Supporting Evidence: PMID:24463821 FGF2 transcriptionally stimulated the expression of miR-149 independently of its host gene |
| GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Negative regulation of oxidative-stress-induced neuronal apoptosis (rat IEA). Reason: FGF2 is a neurotrophic survival factor; context-specific outcome. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | NAS PMID:24463821 Autoregulation of glypican-1 by intronic microRNA-149 fine t... | KEEP AS NON CORE | Summary: FGF2-induced endothelial proliferation modulated by miR-149 feedback. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:24463821 both miR-149 and miR-149* regulated FGF2 signaling and FGF2-induced responses in ECs, namely proliferation, migration and cord formation |
| GO:1903672 positive regulation of sprouting angiogenesis | IDA PMID:16756958 Fibroblast growth factor 16 and 18 are expressed in human ca... | KEEP AS NON CORE | Summary: FGF2 promotes sprouting angiogenesis. Reason: Classical pro-angiogenic outcome of FGF2-FGFR signaling in endothelium; not a core ligand activity. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:1903672 positive regulation of sprouting angiogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: FGF2 promotes sprouting angiogenesis. Reason: Classical pro-angiogenic outcome of FGF2-FGFR signaling in endothelium; not a core ligand activity. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:1903672 positive regulation of sprouting angiogenesis | IMP PMID:23469107 A dominant-negative FGF1 mutant (the R50E mutant) suppresses... | KEEP AS NON CORE | Summary: FGF2 promotes sprouting angiogenesis. Reason: Classical pro-angiogenic outcome of FGF2-FGFR signaling in endothelium; not a core ligand activity. Supporting Evidence: PMID:23469107 excess R50E suppressed FGF2-induced angiogenesis in CAM assays as well |
| GO:1904567 response to wortmannin | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Response to wortmannin (rat IEA). Reason: Drug-response annotation transferred from rat; reflects an experimental treatment, not a function of FGF2. |
| GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation | IGI PMID:23263626 An endothelial apelin-FGF link mediated by miR-424 and miR-5... | KEEP AS NON CORE | Summary: Endothelial FGF2 (derepressed by loss of miR-424/503) stimulates pulmonary artery smooth muscle cell proliferation. Reason: Paracrine mitogenic outcome in a specific vascular context. Supporting Evidence: PMID:23263626 APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. |
| GO:1905278 positive regulation of epithelial tube formation | IDA PMID:31915155 PI3KΞ΄ as a Novel Therapeutic Target in Pathological Angiogen... | KEEP AS NON CORE | Summary: bFGF-induced endothelial tube formation depends on p110delta. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:31915155 p110Ξ΄ activity in cultured ECs controls Akt activation, cell proliferation, migration, and tube formation induced by vascular endothelial growth factor, basic fibroblast growth factor, and epidermal growth factor |
| GO:1905330 regulation of morphogenesis of an epithelium | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ARBA regulation of morphogenesis of an epithelium. Reason: Plausible developmental outcome of FGF signaling; non-core. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:1905555 positive regulation of blood vessel branching | IDA PMID:20123964 Lipid phosphate phosphatase 3 stabilization of beta-catenin ... | KEEP AS NON CORE | Summary: Positive regulation of blood vessel branching (IDA) from an LPP3/beta-catenin endothelial study. Reason: FGF2 presumably used as angiogenic stimulus in the full text; endothelial outcome, non-core. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Can induce |
| GO:1905564 positive regulation of vascular endothelial cell proliferation | IGI PMID:23263626 An endothelial apelin-FGF link mediated by miR-424 and miR-5... | KEEP AS NON CORE | Summary: FGF2/FGFR1 signaling drives pulmonary artery endothelial proliferation, restrained by miR-424/503. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:23263626 APLN deficiency in these cells led to increased expression of FGF2 and its receptor FGFR1 as a consequence of decreased expression of miR-424 and miR-503, which directly target FGF2 and FGFR1. |
| GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor | IDA PMID:16756958 Fibroblast growth factor 16 and 18 are expressed in human ca... | KEEP AS NON CORE | Summary: Endothelial chemotaxis toward FGF (FGF16/18 paper, FGF2 comparator). Reason: FGF2 is itself the chemoattractant here, so it is involved in endothelial chemotaxis to FGF as the cue; retained as non-core. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: ARBA IEA regulation of endothelial chemotaxis to FGF. Reason: Non-core outcome. Supporting Evidence: file:human/FGF2/FGF2-uniprot.txt Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 |
| GO:2000544 regulation of endothelial cell chemotaxis to fibroblast growth factor | NAS PMID:24463821 Autoregulation of glypican-1 by intronic microRNA-149 fine t... | KEEP AS NON CORE | Summary: miR-149 feedback tunes FGF2-induced endothelial migration. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:24463821 both miR-149 and miR-149* regulated FGF2 signaling and FGF2-induced responses in ECs, namely proliferation, migration and cord formation |
| GO:2000546 positive regulation of endothelial cell chemotaxis to fibroblast growth factor | IDA PMID:16756958 Fibroblast growth factor 16 and 18 are expressed in human ca... | KEEP AS NON CORE | Summary: FGF2 promotes endothelial chemotaxis toward FGF. Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:16756958 FGF2, which is mitogenic on endothelial cells and hepatocytes stimulates a sustained MAPK activation in both cell types |
| GO:2000573 positive regulation of DNA biosynthetic process | IDA PMID:16774925 The novel SPARC family member SMOC-2 potentiates angiogenic ... | KEEP AS NON CORE | Summary: FGF2 stimulates endothelial DNA synthesis, potentiated by SMOC-2. Reason: Mitogenic readout of FGF2 signaling; captured more usefully by positive regulation of cell population proliferation. Supporting Evidence: PMID:16774925 Overexpressed SMOC-2 also synergized with vascular endothelial growth factor or with basic fibroblast growth factor to stimulate DNA synthesis. |
| GO:2000573 positive regulation of DNA biosynthetic process | IGI PMID:16774925 The novel SPARC family member SMOC-2 potentiates angiogenic ... | KEEP AS NON CORE | Summary: FGF2 and SMOC-2 synergize to stimulate DNA synthesis (IGI). Reason: As above. Supporting Evidence: PMID:16774925 Overexpressed SMOC-2 also synergized with vascular endothelial growth factor or with basic fibroblast growth factor to stimulate DNA synthesis. |
| GO:2001028 positive regulation of endothelial cell chemotaxis | IGI PMID:16774925 The novel SPARC family member SMOC-2 potentiates angiogenic ... | KEEP AS NON CORE | Summary: FGF2 and SMOC-2 synergize in endothelial invasion/chemotaxis (IGI). Reason: FGF2 is an extracellular FGFR ligand; this process is a downstream cellular or tissue outcome of FGFR signaling in a particular context rather than the intrinsic activity of FGF2. Supporting Evidence: PMID:16774925 Basic fibroblast growth factor and SMOC-2 elicited a synergistic effect on cell invasion. |
| GO:0008201 heparin binding | IDA PMID:11030354 Crystal structure of a ternary FGF-FGFR-heparin complex reve... | NEW | Summary: FGF2 binds heparin/heparan sulfate through a basic surface canyon; heparin contacts both FGF2 and FGFR in the 2:2:2 signaling complex. Reason: Heparin/heparan sulfate binding is a defining, directly demonstrated activity of FGF2 (crystal structures, heparin affinity) and is required for stable FGF2-FGFR complex assembly, yet no heparin-binding row is present for human FGF2. Comparator: FGF1 (same role) carries GO:0008201 by IDA/IMP. This is a molecular function of FGF2 itself, not a process-participation claim. Supporting Evidence: PMID:11030354 heparin makes numerous contacts with both FGF and FGFR, thereby augmenting FGF-FGFR binding PMID:10490103 A positively charged canyon formed by a cluster of exposed basic residues likely represents the heparin-binding site. file:human/FGF2/FGF2-uniprot.txt This protein binds heparin more strongly than does aFGF. file:human/FGF2/FGF2-deep-research-falcon.md Heparan sulfate proteoglycans (HSPGs) function as essential cofactors for FGF2 signaling, not merely as passive binding sites |
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Download this section (compressed HTML)Q: What molecular activity do nuclear high-molecular-weight FGF2 isoforms perform (e.g. with API5/FIF or in nuclear bodies), and is any of it independent of FGFR signaling?
Q: Should FGF2's self-oligomerization and membrane-pore formation during unconventional secretion be captured as participation in its own export (GO protein secretion terms), given that FGF2 itself forms the translocation intermediate?
Q: Is the reported histone H3K9me2/3 reader activity transferred from rat Fgf2 supported by direct binding data, or is it a misannotation?
Q: How essential is integrin alphaVbeta3 binding for FGF2-FGFR signaling in vivo, independent of the originating laboratory's mutant-based model?
Experiment: Knock-in mice expressing only 18 kDa or only HMW FGF2 isoforms, profiled for nuclear interactors (proximity labeling) and transcriptional effects.
Hypothesis: HMW FGF2 isoforms have FGFR-independent nuclear functions distinct from secreted 18 kDa FGF2.
Type: genetic manipulation/proteomics
Experiment: Isothermal titration and nucleosome pull-down assays of recombinant human HMW and LMW FGF2 with H3K9me2/3-modified peptides and nucleosomes.
Hypothesis: FGF2 does not directly read H3K9 methylation; any association is indirect.
Type: biochemistry
Experiment: Compare signaling by wild-type and integrin-binding-defective FGF2 (K119E/R120E, K125E) in ITGB3-knockout versus wild-type endothelial cells with matched FGFR1 levels.
Hypothesis: If integrin binding is required, the mutant defect will be abolished in ITGB3-null cells.
Type: cell signaling
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