FGF3 is a secreted fibroblast growth factor that engages FGF receptors and promotes receptor-dependent proliferative and developmental responses. Conserved receptor-selectivity experiments favor the epithelial splice forms FGFR1b and FGFR2b. Human recessive FGF3 variants cause inner-ear agenesis, microtia and microdontia, linking this ligand to early otic and craniofacial development. Intracellular targeting and nuclear effects in mouse FGF3 construct studies have not established equivalent endogenous human product-specific functions.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005104 fibroblast growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: FGF3 is an FGF receptor ligand. Reason: FGF3 descends from the positive PTN000160075 receptor-binding assertion, with exact canonical MSA correspondence and no on-path IRD. The mouse FGF3 receptor-specificity assays support the conserved ligand role, particularly FGFR1b and FGFR2b; they are not purified human FGF3 binding measurements. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. |
| GO:0005515 protein binding | IPI PMID:16263090 Fibroblast growth factor 3, a protein with a dual subcellula... | UNDECIDED | Summary: The human FGF3 scope of the RPS2 interaction remains unresolved. Reason: The original abstract reports two-hybrid and biochemical association. The publisher Results preview specifies full-length mouse FGF3 bait and a human B-cell library. Complete Methods and remaining assays were not recovered; a human partner does not establish a human FGF3 assay. No ribosome-biogenesis activity is inferred. Supporting Evidence: |
| GO:0005576 extracellular region | IBA GO_REF:0000033 | ACCEPT | Summary: FGF3 acts as an extracellular receptor ligand. Reason: The positive PAINT assertion is on the verified FGF3 path. The reviewed secreted UniProt record and mouse FGF3 receptor-dependent mitogenesis corroborate extracellular ligand activity. This retains the imported active-location assertion without claiming exclusive extracellular localization. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. Supporting Evidence: GO_REF:0000033 file:human/FGF3/FGF3-uniprot.txt file:human/FGF3/FGF3-evidence.yaml |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | ACCEPT | Summary: The secreted-location mapping fits the ligand role. Reason: P11487 states Secreted and carries SL-0243. The signal-peptide boundary is predicted, not a direct human secretion assay; extracellular location agrees with the independently supported ligand role. Propagation Review Root cause: NO FAILURE CORE Sources checked: UniProtKB-SubCell:SL-0243 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0005576 extracellular region | TAS PMID:2470007 Sequence organization of the human int-2 gene and its expres... | UNDECIDED | Summary: The exact 1989 extracellular-location statement remains unresolved. Reason: The accessible PMID:2470007 abstract reports human sequence organization and Tera-2 expression, but does not resolve secretion or extracellular localization. Independent ligand evidence supports the extracellular claim retained in other rows; it does not recover the unread author statement behind this TAS context. Retain UNDECIDED under the source-access rule without implying that FGF3 lacks extracellular activity. Supporting Evidence: |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190245 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190260 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190408 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190427 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033474 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033488 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077421 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077424 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654147 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654149 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654157 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654159 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654165 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654167 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. The captured participant response includes P11487; enclosing complexes may span compartments. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654397 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654399 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654404 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654407 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654511 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654560 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654562 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654569 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654571 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654573 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654575 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654578 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654582 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654584 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654587 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654591 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654592 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654594 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654596 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654597 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654600 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654603 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654605 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654607 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654608 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654672 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654673 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654690 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654692 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654748 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655268 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655301 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655339 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655343 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5656064 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Extracellular ligand location is retained for this source context. Reason: Retain this location because FGF3 functions as an extracellular receptor ligand. The cached event summary alone does not establish a complete target route or assign the reaction mechanism to FGF3. Exact target membership for this event was not independently resolved in the bounded capture. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: The positive ancestral active-compartment inference is retained as non-core. Reason: The literal cytoplasm IBD at PTN000160075 and the verified path to the sequence-matched human PTN002479513 are affirmative support for this phylogenetic inference. GO:0005737 includes organelles but excludes the nucleus; neither mouse nuclear localization nor secretory transit independently proves activity in the human cytoplasm. No target-specific loss was established, and omission from the UniProt location text is not evidence of such loss. Retain the inherited active-compartment claim as non-core while leaving the endogenous human mechanism unresolved. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. Supporting Evidence: GO_REF:0000033 file:human/FGF3/FGF3-evidence.yaml |
| GO:0007165 signal transduction | TAS PMID:2470007 Sequence organization of the human int-2 gene and its expres... | UNDECIDED | Summary: The exact 1989 signal-transduction statement remains unresolved. Reason: The accepted FGFR signaling role independently supports signal transduction, and GO:0008543 is a strict descendant of GO:0007165. However, the accessible PMID:2470007 abstract concerns sequence and expression rather than the evidence underlying this TAS statement. The complete source remains unavailable, so this context retains UNDECIDED rather than converting an unread assertion to TOO_GENERAL; the positive gene-level signaling conclusion is unchanged. Supporting Evidence: |
| GO:0007267 cell-cell signaling | TAS PMID:2470007 Sequence organization of the human int-2 gene and its expres... | UNDECIDED | Summary: The exact 1989 cell-cell-signaling statement remains unresolved. Reason: Receptor-ligand biology is compatible with intercellular signaling, but the accessible PMID:2470007 abstract does not identify the evidence underlying this particular TAS statement and the full article remains unavailable. The checked is_a/part_of ancestry of GO:0008543 does not include GO:0007267, so that pathway does not establish a strict hierarchy-based TOO_GENERAL decision for this term. Retain source-specific uncertainty without denying a possible intercellular role. Supporting Evidence: |
| GO:0008083 growth factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: Growth factor activity is a conserved FGF3 function. Reason: The positive growth-factor IBD is on the verified FGF3 path. Receptor-dependent DNA synthesis after mouse FGF3 exposure corroborates the conserved function. The FHF loss node is not an FGF3 ancestor. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. |
| GO:0008083 growth factor activity | IEA GO_REF:0000002 | ACCEPT | Summary: The FGF domain mapping is appropriate for FGF3. Reason: Official InterPro matches P11487 to IPR002209 at residues 33–187 and maps that entry to GO:0008083. Mouse FGF3 mitogenesis and actual PAINT placement corroborate the mapping; domain membership alone is not an experiment. Propagation Review Root cause: NO FAILURE CORE Sources checked: InterPro:IPR002209 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0008083 growth factor activity | TAS PMID:2470007 Sequence organization of the human int-2 gene and its expres... | UNDECIDED | Summary: The exact 1989 growth-factor statement remains unresolved. Reason: The accessible PMID:2470007 abstract identifies FGF-family sequence homology, which supports the growth-factor hypothesis but does not resolve the author statement underlying this TAS annotation. Positive PAINT/domain evidence and the independently read mouse FGF3 mitogenesis assays support the conserved ligand activity elsewhere in this review. The unread 1989 source remains UNDECIDED under the access rule, not a negative judgment of that activity. Supporting Evidence: |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | ACCEPT | Summary: FGF3 promotes receptor-dependent proliferation. Reason: The positive proliferation IBD is on the verified target path. Mouse FGF3 stimulates DNA synthesis in receptor-transfected BaF3 cells. The human target appearing among IBD sources is expected ancestral curation, not circular evidence. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000117 | ACCEPT | Summary: The proliferation rule agrees with functional evidence. Reason: ARBA00027538 condition set 61 matches the target FunFam and excludes Fungi. Its proliferation output is corroborated by ortholog mitogenesis; the rule is a mapping mechanism, not independent replication. Propagation Review Root cause: NO FAILURE CORE Sources checked: ARBA:ARBA00027538 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF3 supports FGFR-dependent mitogenic responses. Reason: Original Methods and Tables II–III specify mouse FGF3, mouse FGFR1b and human FGFR2b in transfected BaF3 assays. Positive DNA synthesis supports the conserved function and curator-assigned receptor context. This is ortholog corroboration for the human gene, not a purified human FGF3 assay. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF3 supports FGFR-dependent mitogenic responses. Reason: Original Methods and Tables II–III specify mouse FGF3, mouse FGFR1b and human FGFR2b in transfected BaF3 assays. Positive DNA synthesis supports the conserved function and curator-assigned receptor context. This is ortholog corroboration for the human gene, not a purified human FGF3 assay. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: FGF3 supplies the ligand step in FGF receptor signaling. Reason: The positive pathway IBD is on the verified target path and is corroborated by receptor-dependent activity. The ligand engages the receptor; no receptor kinase activity or downstream enzyme reaction is assigned to FGF3. Propagation Review Root cause: NO FAILURE CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: The metazoan FGF rule supports receptor signaling. Reason: ARBA00084988 condition set 10 matches the target FunFam and Metazoa. Its output agrees with PAINT and receptor-dependent mitogenesis without independently establishing each downstream event. Propagation Review Root cause: NO FAILURE CORE Sources checked: ARBA:ARBA00084988 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF3 supplies the receptor-engaging signaling step. Reason: PMID:8663044 Methods, Tables II–III and Figures 2–5 support signaling through FGFR1b and FGFR2b using mouse FGF3. Preserve the imported human-gene source context while specifying the actual mouse ligand. The measured endpoint is mitogenic DNA synthesis, not every intracellular signaling reaction. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF3 supplies the receptor-engaging signaling step. Reason: PMID:8663044 Methods, Tables II–III and Figures 2–5 support signaling through FGFR1b and FGFR2b using mouse FGF3. Preserve the imported human-gene source context while specifying the actual mouse ligand. The measured endpoint is mitogenic DNA synthesis, not every intracellular signaling reaction. |
| GO:0009653 anatomical structure morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Morphogenesis is a contextual signaling outcome. Reason: ARBA00026583 condition set 269 matches the target FunFam. Human recessive variants and inner-ear, auricle and tooth malformations support developmental relevance, while the molecular function is ligand signaling. This retains scope beyond the separate cardiac assay without claiming that the clinical study measured the mechanism. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00026583 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0009653 anatomical structure morphogenesis | TAS PMID:2470007 Sequence organization of the human int-2 gene and its expres... | UNDECIDED | Summary: The exact 1989 morphogenesis statement remains unresolved. Reason: The accessible PMID:2470007 abstract describes mouse embryonic expression and suggests a human embryonic role from sequence and Tera-2 expression; it does not resolve a particular human morphogenetic contribution. The full author statement remains unread. Later human clinical evidence supports the contextual developmental scope retained in the separate electronic row, while this TAS context stays UNDECIDED under the source-access rule. Supporting Evidence: |
| GO:0022008 neurogenesis | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Conserved neurogenesis is retained as contextual. Reason: The positive IBD is on the verified FGF3 ancestry, with exact sequence correspondence and no target-path IRD. No target-specific loss evidence was identified. Retain the phylogenetic judgment without claiming every descendant experiment was reread or that this outcome defines another molecular activity. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. Supporting Evidence: GO_REF:0000033 file:human/FGF3/FGF3-evidence.yaml |
| GO:0030334 regulation of cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Conserved regulation of cell migration is retained as contextual. Reason: The positive IBD is on the verified FGF3 ancestry, with exact sequence correspondence and no target-path IRD. No target-specific loss evidence was identified. Retain the phylogenetic judgment without claiming every descendant experiment was reread or that this outcome defines another molecular activity. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. Supporting Evidence: GO_REF:0000033 file:human/FGF3/FGF3-evidence.yaml |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Conserved positive regulation of MAPK cascade is retained as contextual. Reason: The positive IBD is on the verified FGF3 ancestry, with exact sequence correspondence and no target-path IRD. No target-specific loss evidence was identified. Retain the phylogenetic judgment without claiming every descendant experiment was reread or that this outcome defines another molecular activity. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: PANTHER:PTN000160075 SUPPORTS TRANSFER Actual target path contains the positive IBD; canonical sequence matches the MSA and no IRD is on that path. Aggregate API GO-slim fields are reported separately. Supporting Evidence: GO_REF:0000033 file:human/FGF3/FGF3-evidence.yaml |
| GO:0050793 regulation of developmental process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Broad developmental regulation retains contextual coverage. Reason: ARBA00028689 condition set 231 matches the FGF3 FunFam. Human otic developmental phenotypes and the distinct chick cardiac response support pleiotropic signaling. Although the cardiac term is a typed descendant, it does not exhaust this broader developmental scope. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00028689 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0051239 regulation of multicellular organismal process | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Broad developmental regulation retains contextual coverage. Reason: ARBA00028859 condition set 278 matches the FGF3 FunFam. Human otic developmental phenotypes and the distinct chick cardiac response support pleiotropic signaling. Although the cardiac term is a typed descendant, it does not exhaust this broader developmental scope. Propagation Review Root cause: NO FAILURE NON CORE Sources checked: ARBA:ARBA00028859 SUPPORTS TRANSFER Actual target mapping or matching rule branch is recorded in FGF3-evidence.yaml; biological interpretation is adjudicated separately. |
| GO:0055026 negative regulation of cardiac muscle tissue development | IMP PMID:20702560 BMP-mediated inhibition of FGF signaling promotes cardiomyoc... | KEEP AS NON CORE | Summary: FGF3 delays cardiac differentiation in chick explants. Reason: PMID:20702560 Methods and Figure 3 show exogenous FGF3 inhibition of differentiation and beating in chick anterior-heart-field explants, with ERK pathway evidence. FGF3 reagent species is unstated in the operative Methods; in vivo bead experiments use FGF8. Retain the bounded effect without claiming endogenous human cardiac action or transferring the FGF8 experiment. Supporting Evidence: |
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Download this section (compressed HTML)Q: How much endogenous human FGF3 functions intracellularly, and how is that activity separated from the secreted ligand pool?
Q: Which human FGF3 molecular forms and receptor splice forms provide the inducing signal during inner ear development (GO:0048839), inner ear morphogenesis (GO:0042472), or otic vesicle development (GO:0071599)? Human LAMM cases establish developmental necessity but do not resolve the precise stage or direct process contribution. Mouse Fgf3/Fgf8/Fgf10 comparator records include experimental acts_upstream_of_or_within assertions and TAS involved_in assertions; which corresponding role and stage are supported for human FGF3?
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