FGF8 encodes fibroblast growth factor 8, a secreted heparin-binding signaling ligand produced as a precursor and expressed as four alternative splice isoforms. FGF8 engages FGFR1, FGFR2, FGFR3, and FGFR4 in receptor- and splice-isoform-selective complexes whose affinity and signaling are promoted by heparan-sulfate glycosaminoglycans; receptor activation drives outputs including RAS-MAPK signaling. Differences near the N terminus give FGF8b greater receptor affinity and organizer potency than FGF8a. Spatially and temporally restricted FGF8 acts as an embryonic organizer and morphogen in gastrulation, midbrain-hindbrain regionalization, craniofacial and limb patterning, inner-ear and cardiac development, and development of the gonadotropin-releasing hormone neuronal system. Human loss-of-function variants cause hypogonadotropic hypogonadism with variable olfactory and craniofacial findings, while altered regulation of the FGF8 locus is associated with hypoplastic femurs and pelvis.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005576 extracellular region | IBA GO_REF:0000033 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This row uses phylogenetic inference (IBA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | MARK AS OVER ANNOTATED | Summary: The active FGF8 ligand is secreted; a cytoplasmic location may reflect family-level inference or precursor biosynthesis rather than the compartment in which FGF8 signals. This row uses phylogenetic inference (IBA). Reason: The signal peptide directs nascent FGF8 into the ER and secretory pathway, and the biologically active ligand functions extracellularly. A broad cytoplasmic location inherited from the FGF family is therefore not demonstrably an active FGF8 compartment. Propagation Review Root cause: PROPAGATION BAD Failure modes: COMPARTMENT OR COMPLEX MISMATCH Sources checked: PANTHER:PTN000160075 · FGF-family PAINT node used for the cytoplasm IBA SUPPORTS SOURCE BUT NOT TARGET The family-level node includes intracellular or nonclassically secreted FGF members, whereas human FGF8 has a signal peptide and a supported active extracellular location. |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: FGF8-FGFR signaling is mitogenic in responsive cells and promotes progenitor expansion in multiple developmental contexts. This row uses phylogenetic inference (IBA). Reason: Retained because the positive regulation of cell population proliferation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: FGF8 directly participates in the FGFR signaling pathway by binding and activating fibroblast growth factor receptors. This row uses phylogenetic inference (IBA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The fibroblast growth factor receptor signaling pathway annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:18596921 demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling. |
| GO:0022008 neurogenesis | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: FGF8 signaling contributes to neurogenesis in several embryonic neural territories, including organizer-dependent midbrain and olfactory/GnRH contexts. This row uses phylogenetic inference (IBA). Reason: Retained because the neurogenesis annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0030334 regulation of cell migration | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: FGF8 can regulate migration of responsive embryonic cells and neurons through spatially restricted FGFR signaling. This row uses phylogenetic inference (IBA). Reason: Retained because the regulation of cell migration annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0005105 type 1 fibroblast growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: Biochemical and structural evidence establishes binding of FGF8, especially FGF8b, to FGFR1c. This row uses phylogenetic inference (IBA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The type 1 fibroblast growth factor receptor binding annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:16384934 FGF8b-FGFR1c interaction during mid-hindbrain development. |
| GO:0005111 type 2 fibroblast growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: The FGF8b-FGFR2c crystal structure directly establishes binding to a type 2 fibroblast growth factor receptor. This row uses phylogenetic inference (IBA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The type 2 fibroblast growth factor receptor binding annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:16384934 we solved the crystal structure of FGF8b in complex with the "c" splice isoform of FGF receptor 2 (FGFR2c). |
| GO:0008083 growth factor activity | IBA GO_REF:0000033 | ACCEPT | Summary: FGF8 is a secreted growth factor whose FGFR-dependent activity stimulates mitogenic and developmental responses. This row uses phylogenetic inference (IBA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The growth factor activity annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:18596921 The mutant FGF8b and FGF8f ligands exhibited decreased biological activity in vitro. |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: FGF8 engagement of FGFRs activates the receptor-to-RAS-MAPK signaling branch. This row uses phylogenetic inference (IBA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The positive regulation of MAPK cascade annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:20702560 inhibition of the FGF-ERK pathway is both sufficient and necessary for these processes |
| GO:0009953 dorsal/ventral pattern formation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: FGF8 has conserved context-dependent roles in dorsal-ventral patterning, notably during limb and neural development. This row uses phylogenetic inference (IBA). Reason: Retained because the dorsal/ventral pattern formation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0005105 type 1 fibroblast growth factor receptor binding | IEA GO_REF:0000117 | ACCEPT | Summary: Biochemical and structural evidence establishes binding of FGF8, especially FGF8b, to FGFR1c. This row uses electronic inference (IEA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The type 1 fibroblast growth factor receptor binding annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:16384934 FGF8b-FGFR1c interaction during mid-hindbrain development. |
| GO:0005111 type 2 fibroblast growth factor receptor binding | IEA GO_REF:0000117 | ACCEPT | Summary: The FGF8b-FGFR2c crystal structure directly establishes binding to a type 2 fibroblast growth factor receptor. This row uses electronic inference (IEA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The type 2 fibroblast growth factor receptor binding annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:16384934 we solved the crystal structure of FGF8b in complex with the "c" splice isoform of FGF receptor 2 (FGFR2c). |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This row uses electronic inference (IEA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0008083 growth factor activity | IEA GO_REF:0000002 | ACCEPT | Summary: FGF8 is a secreted growth factor whose FGFR-dependent activity stimulates mitogenic and developmental responses. This row uses electronic inference (IEA). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The growth factor activity annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:18596921 The mutant FGF8b and FGF8f ligands exhibited decreased biological activity in vitro. |
| GO:0050918 positive chemotaxis | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: Spatial FGF8 signaling can direct movement of responsive cells or neurites toward higher ligand activity. This row uses electronic inference (IEA). Reason: Retained because the positive chemotaxis annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0003148 outflow tract septum morphogenesis | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Orthology transfer supports a context-specific FGF8 role in cardiac outflow-tract septum morphogenesis. This row uses electronic inference (IEA). Reason: Retained because the outflow tract septum morphogenesis annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Orthology transfer supports a context-specific role for FGF8 signaling in endocardial-cushion epithelial-to-mesenchymal transition. This row uses electronic inference (IEA). Reason: Retained because the epithelial to mesenchymal transition involved in endocardial cushion formation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0006979 response to oxidative stress | IEA GO_REF:0000107 | UNDECIDED | Summary: This oxidative-stress-response claim is an automatic transfer from a rat ortholog and is not independently exposed by the seeded evidence. This row uses electronic inference (IEA). Reason: The response to oxidative stress annotation was transferred electronically from a rat ortholog, but its underlying source experiment is not exposed here and the claim was not independently corroborated by the FGF8 evidence reviewed. It is left undecided rather than removed. |
| GO:0008045 motor neuron axon guidance | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Orthology transfer supports a context-specific role for FGF8 in motor-neuron axon guidance. This row uses electronic inference (IEA). Reason: Retained because the motor neuron axon guidance annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0009410 response to xenobiotic stimulus | IEA GO_REF:0000107 | UNDECIDED | Summary: This xenobiotic-response claim is an automatic transfer from a rat ortholog and is not independently exposed by the seeded evidence. This row uses electronic inference (IEA). Reason: The response to xenobiotic stimulus annotation was transferred electronically from a rat ortholog, but its underlying source experiment is not exposed here and the claim was not independently corroborated by the FGF8 evidence reviewed. It is left undecided rather than removed. |
| GO:0009897 external side of plasma membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Extracellular FGF8 can be retained at the responding-cell surface through receptor and heparan-sulfate interactions. This row uses electronic inference (IEA). Reason: Retained as a plausible non-core presentation state of a secreted, heparan-sulfate-binding ligand; it does not supersede extracellular region as the principal active location. |
| GO:0021884 forebrain neuron development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: FGF8 supplies positional and trophic signaling during context-specific forebrain-neuron development. This row uses electronic inference (IEA). Reason: Retained because the forebrain neuron development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0021954 central nervous system neuron development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: FGF8 signaling contributes to development of several central-nervous-system neuronal populations. This row uses electronic inference (IEA). Reason: Retained because the central nervous system neuron development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0033563 dorsal/ventral axon guidance | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Orthology transfer supports a context-specific FGF8 role in dorsal-ventral axon guidance. This row uses electronic inference (IEA). Reason: Retained because the dorsal/ventral axon guidance annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0042056 chemoattractant activity | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: FGF8 can provide a spatial extracellular signal that attracts responsive neuronal cells or processes. This row uses electronic inference (IEA). Reason: Retained because the chemoattractant activity annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0045597 positive regulation of cell differentiation | TAS PMID:22235191 Differentiation of the lateral compartment of the cochlea re... | KEEP AS NON CORE | Summary: In the developing cochlea, FGF8-FGFR3 signaling promotes differentiation of pillar cells, a context-specific output. This row uses a traceable author statement (TAS). Reason: Retained because the positive regulation of cell differentiation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | TAS PMID:22235191 Differentiation of the lateral compartment of the cochlea re... | ACCEPT | Summary: FGF8 directly participates in the FGFR signaling pathway by binding and activating fibroblast growth factor receptors. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The fibroblast growth factor receptor signaling pathway annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:18596921 demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling. |
| GO:0010628 positive regulation of gene expression | TAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | KEEP AS NON CORE | Summary: At the isthmic organizer, FGF8 induces or maintains WNT1 expression during midbrain dopaminergic-neuron development. This row uses a traceable author statement (TAS). Reason: Retained because the positive regulation of gene expression annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0071542 dopaminergic neuron differentiation | TAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | KEEP AS NON CORE | Summary: FGF8 cooperates with other signals to specify and promote differentiation of midbrain dopaminergic neurons. This row uses a traceable author statement (TAS). Reason: Retained because the dopaminergic neuron differentiation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. Supporting Evidence: PMID:15193767 When NPCs were treated with FGF8 alone, the DAergic phenotype was expressed lightly. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1839094 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1839098 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-1839100 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190256 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190258 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190261 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190263 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190265 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190326 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190385 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190388 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190413 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-190429 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2012073 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2012074 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2023451 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2023455 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033472 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2033486 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077420 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2077424 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654147 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654148 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654149 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654151 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654157 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654159 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654163 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654165 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654167 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654169 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654222 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654224 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654397 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654399 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654404 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654407 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654408 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654409 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654413 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654416 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654418 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654422 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654423 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654425 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654426 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654428 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654511 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654560 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654562 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654565 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654566 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654569 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654571 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654573 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654575 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654578 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654582 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654584 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654587 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654591 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654592 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654594 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654596 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654597 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654600 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654603 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654605 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654607 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654608 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654623 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654625 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654628 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654631 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654633 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654634 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654637 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654640 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654641 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654643 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654646 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654647 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654651 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654653 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654655 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654658 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654659 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654662 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654663 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654664 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654667 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654669 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654672 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654673 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654679 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654684 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654690 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654692 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654705 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654709 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654714 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654717 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654730 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654734 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5654748 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655240 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655243 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655244 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655247 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655262 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655263 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655266 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655268 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655269 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655270 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655277 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655278 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655285 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655289 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655290 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655295 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655301 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655315 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655326 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655339 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5655343 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5656064 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0005576 extracellular region | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: FGF8 is a secreted, heparan-sulfate-binding ligand whose mature signaling activity occurs in the extracellular region. This Reactome-referenced row is one of multiple source-distinct records for the same valid extracellular location. This row uses a traceable author statement (TAS). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The extracellular region annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: file:human/FGF8/FGF8-uniprot.txt SUBCELLULAR LOCATION: Secreted. |
| GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Orthology transfer supports a context-specific role for FGF8 signaling in endocardial-cushion epithelial-to-mesenchymal transition. This row uses curator-reviewed sequence/orthology transfer (ISS). Reason: Retained because the epithelial to mesenchymal transition involved in endocardial cushion formation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0003148 outflow tract septum morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Orthology transfer supports a context-specific FGF8 role in cardiac outflow-tract septum morphogenesis. This row uses curator-reviewed sequence/orthology transfer (ISS). Reason: Retained because the outflow tract septum morphogenesis annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0055026 negative regulation of cardiac muscle tissue development | IMP PMID:20702560 BMP-mediated inhibition of FGF signaling promotes cardiomyoc... | KEEP AS NON CORE | Summary: In anterior-heart-field progenitors, FGF8/FGF-ERK signaling maintains proliferation and delays premature cardiomyocyte differentiation. This row uses mutant-phenotype evidence (IMP). Reason: Retained because the negative regulation of cardiac muscle tissue development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0071542 dopaminergic neuron differentiation | IDA PMID:15193767 Forskolin cooperating with growth factor on generation of do... | KEEP AS NON CORE | Summary: FGF8 cooperates with other signals to specify and promote differentiation of midbrain dopaminergic neurons. This row uses a direct assay (IDA). Reason: Retained because the dopaminergic neuron differentiation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. Supporting Evidence: PMID:15193767 When NPCs were treated with FGF8 alone, the DAergic phenotype was expressed lightly. |
| GO:0007369 gastrulation | NAS PMID:8700553 The human FGF-8 gene localizes on chromosome 10q24 and is su... | KEEP AS NON CORE | Summary: Embryonic expression and vertebrate genetic evidence support a context-specific FGF8 role in gastrulation. This row uses a non-traceable author statement (NAS). Reason: Retained because the gastrulation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0009653 anatomical structure morphogenesis | NAS PMID:8595889 Assignment of FGF8 to human chromosome 10q25-q26: mutations ... | KEEP AS NON CORE | Summary: FGF8 has broad, conserved roles in embryonic tissue outgrowth and patterning, making anatomical morphogenesis a true but nonspecific consequence. This row uses a non-traceable author statement (NAS). Reason: Retained as a biologically accurate but very broad developmental consequence. More specific FGF8 tissue-patterning annotations are more informative, and morphogenesis is not a separate intrinsic molecular activity of the ligand. |
| GO:0060563 neuroepithelial cell differentiation | IDA PMID:17309880 Over-expression of alpha-synuclein in human neural progenito... | KEEP AS NON CORE | Summary: FGF8/SHH treatment is used to specify differentiating human neuroepithelial cultures, supporting a context-specific differentiation role. This row uses a direct assay (IDA). Reason: Retained because the neuroepithelial cell differentiation annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0042476 odontogenesis | IEP PMID:17394220 Expression survey of genes critical for tooth development in... | KEEP AS NON CORE | Summary: FGF8 expression in human dental epithelium supports a context-specific role during odontogenesis. This row uses expression-pattern evidence (IEP). Reason: Retained because the odontogenesis annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. Supporting Evidence: PMID:17394220 FGF8 expression remained in the dental epithelium at the cap stage |
| GO:0008406 gonad development | IMP PMID:18596921 Decreased FGF8 signaling causes deficiency of gonadotropin-r... | KEEP AS NON CORE | Summary: Reduced FGF8 signaling disrupts the GnRH neuronal system and secondarily impairs reproductive maturation; this is not evidence for a separate intrinsic gonadal activity. This row uses mutant-phenotype evidence (IMP). Reason: Retained because the gonad development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0060348 bone development | IMP PMID:18596921 Decreased FGF8 signaling causes deficiency of gonadotropin-r... | KEEP AS NON CORE | Summary: Human FGF8 variant carriers can show skeletal phenotypes and vertebrate studies support skeletal patterning roles, although some human bone effects may be secondary to hypogonadism. This row uses mutant-phenotype evidence (IMP). Reason: Retained because the bone development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. |
| GO:0001656 metanephros development | IEP PMID:18437684 Involvement of FGF and BMP family proteins and VEGF in early... | KEEP AS NON CORE | Summary: FGF8 protein expression in early human metanephric structures supports a context-specific association with metanephros development. This row uses expression-pattern evidence (IEP). Reason: Retained because the metanephros development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. Supporting Evidence: PMID:18437684 In the metanephros, FGF-8 first appeared only in the metanephric mesenchyme |
| GO:0001823 mesonephros development | IEP PMID:18437684 Involvement of FGF and BMP family proteins and VEGF in early... | KEEP AS NON CORE | Summary: FGF8 protein expression in early human mesonephric structures supports a context-specific association with mesonephros development. This row uses expression-pattern evidence (IEP). Reason: Retained because the mesonephros development annotation is biologically consistent with FGF8 signaling evidence, but it describes a downstream cellular response or tissue-specific developmental context rather than the ligand's defining molecular activity. Supporting Evidence: PMID:18437684 In the mesonephros, both FGF's and BMP's were found in all structures |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF8 directly participates in the FGFR signaling pathway by binding and activating fibroblast growth factor receptors. This row uses genetic-interaction evidence (IGI). Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The fibroblast growth factor receptor signaling pathway annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:18596921 demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF8 directly participates in the FGFR signaling pathway by binding and activating fibroblast growth factor receptors. This source-distinct IGI row records FGFR3 as the supporting entity. Reason: Retained as part of the defining extracellular FGFR-ligand function of FGF8. The fibroblast growth factor receptor signaling pathway annotation is consistent with direct receptor-binding, mitogenic, structural, and signaling evidence. Supporting Evidence: PMID:18596921 demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling. |
| GO:0005104 fibroblast growth factor receptor binding | IDA PMID:16384934 Structural basis by which alternative splicing modulates the... | NEW | Summary: Proposed new general molecular-function annotation. The FGF8b-FGFR2c crystal structure and biochemical evidence for physiological FGF8b-FGFR1c interaction directly establish fibroblast growth factor receptor binding; existing GOA child terms separately record FGFR1 and FGFR2 binding. Reason: GO:0005104 accurately unifies the directly demonstrated receptor-binding activity used in the core-function model without asserting that every receptor splice isoform binds with equal affinity. Supporting Evidence: PMID:16384934 we solved the crystal structure of FGF8b in complex with the "c" splice isoform of FGF receptor 2 (FGFR2c). PMID:16384934 provide the first biochemical evidence for a physiological FGF8b-FGFR1c interaction during mid-hindbrain development. |
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Download this section (compressed HTML)Q: How do the four human FGF8 splice isoforms partition receptor-splice specificity, tissue range, and organizer potency in vivo?
Q: Which FGFR isoforms and heparan-sulfate structures receive FGF8 at the human midbrain-hindbrain boundary, and how faithfully do human cerebellar organoids reproduce that organizer circuit?
Q: Which skeletal findings in human FGF8 deficiency reflect direct local FGF8 signaling rather than secondary effects of GnRH and sex-steroid deficiency?
Experiment: Introduce isoform-selective FGF8A or FGF8B expression into isogenic human midbrain-hindbrain organoids and quantify OTX2/GBX2 boundary position, WNT1 maintenance, FGFR phosphorylation, ERK dynamics, and cerebellar-territory markers.
Hypothesis: FGF8B produces stronger and longer-range FGFR-ERK signaling than FGF8A and more effectively stabilizes the human isthmic organizer.
Type: genetic manipulation/organoid imaging
Experiment: Measure binding kinetics and signaling potency of all four purified human FGF8 isoforms across FGFR1c, FGFR2c, FGFR3c, FGFR3b, and FGFR4 with defined heparan-sulfate oligosaccharides.
Hypothesis: Isoform-specific N-terminal contacts and heparan-sulfate composition jointly determine receptor selectivity and signaling amplitude.
Type: biochemistry/quantitative signaling
Experiment: Generate isogenic human neural and skeletal progenitors carrying disease-associated FGF8 variants, then compare secretion, receptor binding, ERK activation, GnRH-neuron differentiation, and osteogenic/chondrogenic outcomes with hormone-independent rescue controls.
Hypothesis: Different FGF8 variants separate primary ligand defects from secondary endocrine consequences and reveal tissue-specific signaling thresholds.
Type: genome editing/cell differentiation
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