FGF9

Summary: FGF9 signaling contributes to eye development.

Reason: The mouse P54130 donor has an IMP annotation from PMID:21858205. Its Fgf9 Y162C allelic study documents prenatal and postnatal lens-growth abnormalities (Results, Figures 8–9), with normal retinal measurements in that model. Retain the orthology-based developmental inference as a contextual ligand function; this is not a human lens experiment or proof that the neomorphic allele simply abolishes normal FGF9 activity.

Summary: FGF9 binds fibroblast growth factor receptors.

Reason: The inherited PAINT assertion is supported by direct receptor-binding and signaling experiments with human FGF9 constructs in PMID:28757146 (Results, Figures 1 and 4–5; STAR Methods). Receptor splice form, ligand truncation and engineered receptor mutations affect the measured specificity. The older PMID:8663044 panel used mouse FGF9 and measured receptor-dependent mitogenesis, not direct affinity. FGFR binding is the molecular recognition step of the growth-factor core.

Summary: FGF9 is a secreted extracellular ligand.

Reason: The positive PAINT ancestry is consistent with human secretion experiments. The explicit PMID:8321227 abstract reports secretion from transfected COS cells; recovered original Results around Figure 5 characterize mitogenic CHO-derived secreted products. The non-cleaved secretion signal is compatible with ER entry; absence of a conventional cleaved signal peptide is not evidence for cytosolic confinement.

Summary: FGF9 is a secreted extracellular ligand.

Reason: The original human cDNA experiment supplies positive localization evidence. The explicit PMID:8321227 abstract reports secretion from transfected COS cells; recovered original Results around Figure 5 characterize mitogenic CHO-derived secreted products. The non-cleaved secretion signal is compatible with ER entry; absence of a conventional cleaved signal peptide is not evidence for cytosolic confinement.

Summary: FGF9 is a secreted extracellular ligand.

Reason: The current UniProt Secreted location (SL-0243) is mapped to the correct extracellular term. The explicit PMID:8321227 abstract reports secretion from transfected COS cells; recovered original Results around Figure 5 characterize mitogenic CHO-derived secreted products. The non-cleaved secretion signal is compatible with ER entry; absence of a conventional cleaved signal peptide is not evidence for cytosolic confinement.

Summary: FGF9 is a secreted extracellular ligand.

Reason: The source statement agrees with the experimental secretion data. The explicit PMID:8321227 abstract reports secretion from transfected COS cells; recovered original Results around Figure 5 characterize mitogenic CHO-derived secreted products. The non-cleaved secretion signal is compatible with ER entry; absence of a conventional cleaved signal peptide is not evidence for cytosolic confinement.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 3 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 3 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 3 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 2 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: Extracellular FGF9 is retained in this receptor-signaling source context.

Reason: The saved event participant expansion contains P31371 within 1 ligand-containing entity/set context(s). The reviewed claim is the ligand location. Human secretion in PMID:8321227 independently supports that same claim, and Reactome entity R-HSA-189870 explicitly represents P31371 residues 4–208 in extracellular region. A ligand can remain part of a receptor complex while intracellular enzymes act; the event title does not confer their kinase, GEF or lipid-enzyme activity on FGF9.

Summary: The positive PAINT assertion supports an inherited, non-core cytoplasmic role.

Reason: The literal positive cytoplasm IBD at PTN000160075 is inherited by the sequence-verified FGF9 leaf PTN002479527; this curated ancestral assertion supplies the positive support. All 35 saved family assertions were checked and no IRD lies on the target path. Donor composition and different review actions for other FGF genes do not themselves establish loss in FGF9 or overturn the ancestral placement. GO:0005737 includes cytoplasmic organelles, but that breadth only makes ER/Golgi transit compatible with the location; it does not demonstrate molecular activity there. The rat microsomal/COS experiments in PMID:10506195 and the abstract-level ER/Golgi report in PMID:10713129 are trafficking evidence, not proof of active human cytoplasmic FGF9. Retain the positive phylogenetic inference as non-core while explicitly leaving an endogenous human cytoplasmic mechanism experimentally unestablished; no cytoplasmic FGFR-ligand activity is asserted.

Summary: The source-specific broad signaling statement could not be assessed.

Reason: PMID:8575785 was available only as bibliographic metadata, without its original body or an abstract supporting this TAS context. Independent FGF9 receptor-response studies establish signaling, but do not recover what this source asserted. Keep this source-specific decision unresolved. The verified ancestry of GO:0008543 beneath GO:0007165 explains the more informative pathway retained elsewhere; it does not adjudicate the unavailable mapping paper.

Summary: The original cell-cell signaling statement remains inaccessible.

Reason: The original PMID:8575785 source was available only as bibliographic metadata. Secreted human FGF9 activity and receptor-dependent responses independently support intercellular signaling biology, but the specific TAS statement cannot be checked. Retain uncertainty for this source context without denying the ligand role. No strict ancestry between GO:0007267 and GO:0008543 was established.

Summary: FGF9 has growth factor activity.

Reason: The growth-factor IBD lies on the verified human FGF9 lineage. The term requires stimulation of cell growth or proliferation, not binding alone. Recovered PMID:8321227 Results around Figure 5 report mitogenic activity of the human-FGF9-derived CHO products; the receptor-dependent mitogenesis panel in PMID:8663044 supplies complementary mouse-ligand evidence. This is the defining extracellular ligand function.

Summary: FGF9 has growth factor activity.

Reason: The official IPR002209 record maps to GO:0008083 and matches P31371 residues 48–193. The term requires stimulation of cell growth or proliferation, not binding alone. Recovered PMID:8321227 Results around Figure 5 report mitogenic activity of the human-FGF9-derived CHO products; the receptor-dependent mitogenesis panel in PMID:8663044 supplies complementary mouse-ligand evidence. This is the defining extracellular ligand function.

Summary: FGF9 has growth factor activity.

Reason: The original human FGF9 study supplies mitogenic activity data. The term requires stimulation of cell growth or proliferation, not binding alone. Recovered PMID:8321227 Results around Figure 5 report mitogenic activity of the human-FGF9-derived CHO products; the receptor-dependent mitogenesis panel in PMID:8663044 supplies complementary mouse-ligand evidence. This is the defining extracellular ligand function.

Summary: FGF9 stimulates proliferation of responsive cell populations.

Reason: Human FGF9-derived CHO products have mitogenic activity (recovered PMID:8321227 Results around Figure 5); the explicit abstract separately reports secretion into COS-cell medium. Receptor-dependent mitogenesis is also measured in PMID:8663044, using mouse FGF9. The broad proliferative role spans responsive cell types and is retained in the ligand core; the more specific vascular-smooth-muscle contexts do not exhaust it.

Summary: FGF9 stimulates proliferation of responsive cell populations.

Reason: Human FGF9-derived CHO products have mitogenic activity (recovered PMID:8321227 Results around Figure 5); the explicit abstract separately reports secretion into COS-cell medium. Receptor-dependent mitogenesis is also measured in PMID:8663044, using mouse FGF9. The broad proliferative role spans responsive cell types and is retained in the ligand core; the more specific vascular-smooth-muscle contexts do not exhaust it.

Summary: FGF9 initiates FGFR signaling as a receptor ligand.

Reason: The verified positive IBD agrees with receptor-dependent responses and direct human-construct binding/signaling experiments. FGF9 performs the ligand-binding step; the receptor performs phosphorylation. Specificity depends on receptor splice form and ligand construct, as documented in PMID:8663044 Table III and PMID:28757146 Figures 4–5.

Summary: FGF9 activates signaling through responsive FGFR1 receptor forms.

Reason: PMID:8663044 Table III measures mitogenesis in receptor-reconstituted BaF3 cells. Table II identifies the FGF9 reagent as mouse; receptor constructs include different species and, for FGFR3/4, extracellular-domain chimeras. Responses depend on splice form and include FGFR3b, so neither universal receptor activation nor absolute c-isoform exclusivity follows. Modern human FGF9-construct assays corroborate FGFR signaling (PMID:28757146). The original IGI source and WITH entity remain intact.

Summary: FGF9 activates signaling through responsive FGFR2 receptor forms.

Reason: PMID:8663044 Table III measures mitogenesis in receptor-reconstituted BaF3 cells. Table II identifies the FGF9 reagent as mouse; receptor constructs include different species and, for FGFR3/4, extracellular-domain chimeras. Responses depend on splice form and include FGFR3b, so neither universal receptor activation nor absolute c-isoform exclusivity follows. Modern human FGF9-construct assays corroborate FGFR signaling (PMID:28757146). The original IGI source and WITH entity remain intact.

Summary: FGF9 activates signaling through responsive FGFR3 receptor forms.

Reason: PMID:8663044 Table III measures mitogenesis in receptor-reconstituted BaF3 cells. Table II identifies the FGF9 reagent as mouse; receptor constructs include different species and, for FGFR3/4, extracellular-domain chimeras. Responses depend on splice form and include FGFR3b, so neither universal receptor activation nor absolute c-isoform exclusivity follows. Modern human FGF9-construct assays corroborate FGFR signaling (PMID:28757146). The original IGI source and WITH entity remain intact.

Summary: FGF9 expression accompanies human fetal testis development.

Reason: The original observational study measured FGF9 transcripts in human second-trimester testes (PMID:17848411, Results and Figure 4). Expression increased per testis but not significantly per Sertoli cell. Retain the curator’s IEP developmental association as a contextual role of the ligand; this source does not demonstrate an FGF9 perturbation, a human sex-determination mechanism or Sertoli-cell-specific causal action.

Summary: Adult substantia-nigra protein abundance does not establish substantia-nigra development.

Reason: The exact P31371 glia-activating-factor entry is present in PMID:22926577 Table 2. The original Methods and Table 1 describe adult postmortem human disease/control samples, not formation or maturation of the substantia nigra. A broad neural-development category in the proteomic table does not establish GO:0021762. The target identification is positive; the over-annotation is the developmental interpretation of this HEP source, not an alleged wrong-gene identification.

Summary: FGF9 retains an inherited contextual role in neurogenesis.

Reason: The neurogenesis IBD is present at PTN000160075 and the exact human FGF9 sequence descends from it without an intervening IRD. Retain the considered phylogenetic inference; the lack of a human target in this term’s donor list does not demonstrate loss. The adult substantia-nigra HEP record is a different, narrower claim and is not used as a developmental assay here. Neurogenesis is a tissue-level outcome rather than an additional molecular core.

Summary: FGF9 signaling can regulate cell migration.

Reason: The verified migration IBD remains positive on the FGF9 lineage. In the rat donor study PMID:28259995, FGF9 knockdown reduced PDGF-BB-associated smooth-muscle migration (Results and Figure 5). Retain the broad inherited signaling outcome, with cell and organism dependence, outside the defining receptor-ligand activity.

Summary: FGF9 can promote ERK/MAPK signaling through FGFRs.

Reason: The positive PAINT ancestry is corroborated by ERK phosphorylation in receptor-reconstituted cells treated with human FGF9 constructs (PMID:28757146, Figures 4–5). This is a supported downstream signaling output, not MAPK catalysis by FGF9. The core summarizes the initiating FGFR-ligand step without making every downstream branch a separate core function.

Summary: FGF9 supports proliferation in the studied human smooth-muscle cell system.

Reason: PMID:29118903 uses a human aortic smooth-muscle cell line. Figure 3E shows FGF9 expression restoring the CCK-8 proliferation proxy suppressed by miR-665; Figures 3B–D support the FGF9 RNA-target relationship. The purchased FGF9 construct is not sequence-resolved in the read Methods. This supports the contextual positive role, but not every migration or Wnt effect of a miRNA with another tested target, MEF2D. Figure 2 caption directions conflict with the Results, and Figure 3A says 5′ UTR whereas its caption/Methods say 3′ UTR; the reviewed FGF9 rescue direction is visible in Figure 3E.

Summary: FGF9 supports vascular smooth-muscle proliferation.

Reason: Rat aortic SMC FGF9 knockdown reduced MTT and EdU responses with and without PDGF-BB. The actual donor P36364 annotations point to PMID:28259995 (Results, Figures 5–6). Retain the curated ISS transfer as a context-dependent mammalian ligand role, not as a new direct experiment on human FGF9 or a demonstration that FGF9 binds PDGFRβ.

Summary: FGF9 supports vascular smooth-muscle migration.

Reason: Rat aortic SMC FGF9 knockdown reduced PDGF-BB-induced migration. The actual donor P36364 annotations point to PMID:28259995 (Results, Figures 5–6). Retain the curated ISS transfer as a context-dependent mammalian ligand role, not as a new direct experiment on human FGF9 or a demonstration that FGF9 binds PDGFRβ.

Summary: FGF9 can oppose the contractile differentiation state of vascular smooth muscle.

Reason: FGF9 knockdown increased SMA and SM22α contractile markers; the marker direction supports negative regulation of differentiation despite inconsistent use of differentiation/dedifferentiation in some prose. The actual donor P36364 annotations point to PMID:28259995 (Results, Figures 5–6). Retain the curated ISS transfer as a context-dependent mammalian ligand role, not as a new direct experiment on human FGF9 or a demonstration that FGF9 binds PDGFRβ.