FGFR2 is a fibroblast growth factor receptor tyrosine kinase. Membrane-spanning receptors bind extracellular FGFs with heparan sulfate-dependent modulation, dimerize and couple tyrosine phosphorylation to pathways including RAS–MAPK and PLCG1. These signals regulate proliferation, differentiation and tissue morphogenesis, including skeletal and branching-organ development. Alternative IIIb/IIIc exon use changes part of the third extracellular immunoglobulin-like domain and alters, rather than completely separates, ligand preferences: FGF1 can activate both receptor forms; FGF7 and FGF10 preferentially stimulate IIIb, whereas FGF2 and FGF9 favor IIIc in established receptor assays. IIIb/KGFR and IIIc/BEK are often associated with epithelial and mesenchymal expression, respectively, with context-dependent expression and signaling. Human FGFR2 variants cause craniosynostosis syndromes. Alternative splicing also produces soluble receptors and other forms whose physiological activities are less completely established than those of the principal membrane receptors.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005007 fibroblast growth factor receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 binds FGFs and transmits signals across the plasma membrane. Reason: The positive fibroblast growth factor receptor activity IBD at PTN000699279 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors file:human/FGFR2/FGFR2-deep-research-falcon.md FGFR2 is a member of the FGFR receptor tyrosine kinase family that transduces extracellular fibroblast growth factor (FGF) signals into intracellular phosphorylation-dependent signaling programs that control proliferation, survival, differentiation, and migration. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: The positive plasma membrane IBD at PTN001230349 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 signaling promotes cell population proliferation. Reason: The IBD for positive regulation of cell population proliferation IBD at PTN004704281 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 Promotes cell proliferation in keratinocytes and immature osteoblasts file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 transduces signals from extracellular FGF ligands. Reason: The positive fibroblast growth factor receptor signaling pathway IBD at PTN004704281 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0001525 angiogenesis | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to angiogenesis. Reason: The positive angiogenesis IBD at PTN002814665 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Angiogenesis is retained as a developmental context rather than the central receptor activity. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 signaling promotes MAPK-cascade activation. Reason: The IBD for positive regulation of MAPK cascade IBD at PTN004704281 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0043235 receptor complex | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 participates in receptor complexes. Reason: The positive receptor complex IBD at PTN001230349 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 Monomer. Homodimer after ligand binding. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0017134 fibroblast growth factor binding | IBA GO_REF:0000033 | ACCEPT | Summary: FGFR2 binds fibroblast growth factors. Reason: The positive fibroblast growth factor binding IBD at PTN000699279 exactly matches the imported PAINT source. This is an ancestral curator judgment, not a pairwise donor vote. Independent receptor biology is concordant; target topology/MSA were not independently recovered, so no target-specific loss or exclusion is asserted. Supporting Evidence: UniProtKB:P21802 Isoform 1 has high affinity for FGF1 and FGF2, but low affinity for FGF7. Isoform 3 has high affinity for FGF1 and FGF7 file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0000166 nucleotide binding | IEA GO_REF:0000043 | ACCEPT | Summary: The FGFR2 kinase domain binds nucleotides. Reason: The imported nucleotide binding mapping is consistent with the membrane receptor kinase architecture and curated UniProt/InterPro source. It is a broader facet of the same receptor function, not an additional independent activity or a claim that soluble kinase-lacking products share it. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | ACCEPT | Summary: FGFR2 has protein kinase activity. Reason: The imported protein kinase activity mapping is consistent with the membrane receptor kinase architecture and curated UniProt/InterPro source. It is a broader facet of the same receptor function, not an additional independent activity or a claim that soluble kinase-lacking products share it. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: FGFR2 catalyzes protein tyrosine phosphorylation. Reason: The protein tyrosine kinase activity mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: UniProtKB:P21802 Phosphorylates PLCG1, FRS2 and PAK4 file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0004714 transmembrane receptor protein tyrosine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: FGFR2 is a transmembrane receptor tyrosine kinase. Reason: The imported transmembrane receptor protein tyrosine kinase activity mapping is consistent with the membrane receptor kinase architecture and curated UniProt/InterPro source. It is a broader facet of the same receptor function, not an additional independent activity or a claim that soluble kinase-lacking products share it. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005007 fibroblast growth factor receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: FGFR2 binds FGFs and transmits signals across the plasma membrane. Reason: The fibroblast growth factor receptor activity mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005524 ATP binding | IEA GO_REF:0000120 | ACCEPT | Summary: FGFR2 binds ATP for its kinase reaction. Reason: The ATP binding mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Soluble FGFR2 products can occur extracellularly. Reason: UniProt subcellular mapping supports the soluble products named 8 and 13, whose stable identifiers are P21802-14 and P21802-19. This extracellular pool is distinct from the principal membrane receptor; a physiological decoy mechanism was not established. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005794 Golgi apparatus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: FGFR2 can occur in the Golgi during receptor trafficking. Reason: The UniProt Golgi mapping and original PMID16844695 glycosylation/retention experiments support an intracellular receptor pool. Trafficking and engineered-mutant retention do not define the primary signaling location of every natural splice product. Supporting Evidence: UniProtKB:P21802 SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: The plasma membrane mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0006915 apoptotic process | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: FGFR2 signaling can influence apoptosis in specific cellular contexts. Reason: UniProt notes FGFR2 "promotes apoptosis in differentiated osteoblasts" but this is context-dependent and not a primary function. The annotation is valid but represents a secondary/context-specific role. Supporting Evidence: UniProtKB:P21802 Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008201 heparin binding | IEA GO_REF:0000043 | ACCEPT | Summary: FGFR2 ligand recognition is modulated by heparin/heparan-sulfate interactions. Reason: Heparan sulfate-dependent receptor–ligand assembly is consistent with the imported UniProt heparin-binding keyword. PMID8663044 explicitly bounds its receptor-response comparisons by the heparin-containing assay; this does not equate heparin dependence with identical affinity in every product. Supporting Evidence: UniProtKB:P21802 Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000120 | ACCEPT | Summary: FGFR2 signaling promotes cell population proliferation. Reason: The positive regulation of cell population proliferation mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IEA GO_REF:0000120 | ACCEPT | Summary: FGFR2 transduces signals from extracellular FGF ligands. Reason: The fibroblast growth factor receptor signaling pathway mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0016020 membrane | IEA GO_REF:0000002 | ACCEPT | Summary: Membrane-spanning FGFR2 is membrane-associated. Reason: The imported membrane mapping is consistent with the membrane receptor kinase architecture and curated UniProt/InterPro source. It is a broader facet of the same receptor function, not an additional independent activity or a claim that soluble kinase-lacking products share it. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0016301 kinase activity | IEA GO_REF:0000043 | ACCEPT | Summary: FGFR2 transfers phosphate groups through its kinase domain. Reason: The imported kinase activity mapping is consistent with the membrane receptor kinase architecture and curated UniProt/InterPro source. It is a broader facet of the same receptor function, not an additional independent activity or a claim that soluble kinase-lacking products share it. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0016740 transferase activity | IEA GO_REF:0000043 | ACCEPT | Summary: FGFR2 catalysis transfers phosphate from ATP to proteins. Reason: The imported transferase activity mapping is consistent with the membrane receptor kinase architecture and curated UniProt/InterPro source. It is a broader facet of the same receptor function, not an additional independent activity or a claim that soluble kinase-lacking products share it. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0031410 cytoplasmic vesicle | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: FGFR2 can occur in cytoplasmic trafficking vesicles. Reason: The combined electronic mapping retains a vesicular receptor-trafficking location. It is contextual localization, not an independently characterized vesicular activity for all natural products. Supporting Evidence: UniProtKB:P21802 After ligand binding, the activated receptor is rapidly internalized and degraded file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0033688 regulation of osteoblast proliferation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: FGFR2 signaling regulates osteoblast proliferation in a developmental context. Reason: The inspected P21802 UniProt FUNCTION statement explicitly includes osteoblast proliferation, and human FGFR2 S252W osteoblast responses in PMID:15190072 support its role in this lineage. The specific proliferation endpoint in that paper remains unread; the established gene-level claim is retained with curator deference, not an invented assay. Current ARBA00084763 does not match the saved target features and its historical version remains unresolved, limiting provenance without demonstrating biological loss. |
| GO:0043009 chordate embryonic development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to chordate embryonic development. Reason: The electronic chordate embryonic development annotation is retained in the developmental context of FGFR2 signaling and the curated UniProt record. The current rule/target join is documented in the source evidence; it is not a separate human experiment. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0043410 positive regulation of MAPK cascade | IEA GO_REF:0000117 | ACCEPT | Summary: FGFR2 signaling promotes MAPK-cascade activation. Reason: The positive regulation of MAPK cascade mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0045595 regulation of cell differentiation | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: FGFR2 signaling modulates cell differentiation. Reason: The electronic regulation of cell differentiation annotation is retained in the developmental context of FGFR2 signaling and the curated UniProt record. The current rule/target join is documented in the source evidence; it is not a separate human experiment. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048562 embryonic organ morphogenesis | IEA GO_REF:0000117 | ACCEPT | Summary: FGFR2 signaling contributes to embryonic organ morphogenesis. Reason: The actual current ARBA00043470 condition set matches the saved target features and human lineage. This embryonic organ-morphogenesis inference is concordant with the retained mouse Fgfr2 transfer and receptor developmental role; it is not a separate human experiment or an all-product assertion. Supporting Evidence: UniProtKB:P21802 Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048705 skeletal system morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to skeletal system morphogenesis. Reason: Human FGFR2 variants are associated with altered cranial morphology in the clinical abstracts PMID:7987400 and PMID:7874170, and the curated UniProt record describes a requirement for normal skeleton development. These support the broad skeletal claim and contextual electronic inference. They do not specify the embryonic-stage mechanism of GO:0048701, and the PMID:7874170 erratum remains unread. |
| GO:1904888 cranial skeletal system development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to cranial skeletal system development. Reason: The electronic cranial skeletal system development annotation is retained in the developmental context of FGFR2 signaling and the curated UniProt record. The current rule/target join is documented in the source evidence; it is not a separate human experiment. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:10618369 Structural interactions of fibroblast growth factor receptor... | MODIFY | Summary: The extracellular FGFR2IIIc fragment binds FGF1. Reason: Original PMID10618369 Methods and structural Results directly describe human FGF1 contacts with a recombinant FGFR2IIIc extracellular fragment. Fibroblast growth factor binding identifies the measured partner class more informatively than generic binding; the fragment experiment is not a physiological comparison of all products. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:10618369 Structural interactions of fibroblast growth factor receptor with its ligands. |
| GO:0005515 protein binding | IPI PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the dete... | MODIFY | Summary: FGFR2 ligand-binding domains form a complex with FGF2. Reason: The PMID:10830168 abstract explicitly identifies FGF2 complexed with FGFR2 D2–D3 domains. This supports the specific FGF-binding replacement. Complete original Methods and exact construct provenance remain unread; no function is assigned to all natural receptor products. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:11390973 Structural basis for fibroblast growth factor receptor 2 act... | MODIFY | Summary: Apert-mutant FGFR2 extracellular fragments bind FGF2. Reason: The recovered original PMID11390973 Results and Figure 1/2 captions describe FGF2 contacts with S252W/P253R FGFR2 extracellular complexes. The specific ligand-binding replacement is supported at that construct scope; complete construct Methods were not recovered. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:11390973 Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome. |
| GO:0005515 protein binding | IPI PMID:12591959 Structural basis by which alternative splicing confers speci... | MODIFY | Summary: The FGFR2b extracellular region recognizes FGF10. Reason: The PMID:12591959 abstract reports the FGF10–FGFR2b crystal complex and contacts involving b-specific D3 loops. That is positive evidence for the specific FGF-binding replacement. Complete construct Methods remain unread; FGF10 recognition is not assigned to every splice product. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:12591959 Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:1309608 Determination of ligand-binding specificity by alternative s... | MODIFY | Summary: Human KGFR and BEK bind FGFs with different preferences and shared FGF1 recognition. Reason: The PMID:1309608 abstract explicitly reports human receptor cloning and differential binding of KGF/FGF7, acidic FGF/FGF1 and basic FGF/FGF2. Fibroblast growth factor binding captures the measured partner class. Original scanned pages and detailed assay conditions remain unread. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:1309608 Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:22726438 Inhibition of basal FGF receptor signaling by dimeric Grb2. | KEEP AS NON CORE | Summary: GRB2 binds FGFR2 and controls its basal activation state. Reason: The PMID:22726438 abstract explicitly reports dimeric GRB2 binding the C termini of two FGFR2 molecules and dissociation after receptor-mediated phosphorylation. This supports association without transferring GRB2 adaptor activity to FGFR2. Complete interaction Methods remain unread, and no independently verified binding subtype is asserted. Supporting Evidence: PMID:22726438 Inhibition of basal FGF receptor signaling by dimeric Grb2. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:23597563 Molecular mechanism of SSR128129E, an extracellularly acting... | MODIFY | Summary: FGFR2 extracellular fragments bind the FGF1 ligand. Reason: Five positive human IntAct NMR/direct-interaction records join P21802 with processed FGF1 P05230-PRO_0000008908, including EBI-6664176 and EBI-6880933 at Figure 3D/E. Together with independently read FGFR2–FGF1 structural evidence in PMID:10618369, these support specific FGF binding. The inhibitor context does not erase the protein pair. Original panels and the later erratum remain unread; fragment records do not establish all-product behavior or a new affinity measurement. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:23597563 Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | UNDECIDED | Summary: FGFR2–FGF proximity is reported, but its interpretation as binding remains unresolved. Reason: Exact IntAct records describe FGFR2 proximity to FGF1/FGF10 in HeLa PLA assays. Original panels remain unread, and proximity alone does not resolve direct binding. Supporting Evidence: PMID:25241761 Oct 9. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:26267536 Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for... | MODIFY | Summary: FGFR2 extracellular fragments bind the FGF2 ligand. Reason: Positive human IntAct NMR/direct records EBI-11479333 and EBI-11479345 join FGFR2 residues 147–249 to FGF2 isoform 2 residues 1–154 at Supplementary 3B/3Bi; the latter records antagonist-mediated reduction of this interaction. These support specific FGF binding, corroborated by the FGF2–FGFR2 complex in PMID:10830168. Original supplementary panels remain unread; fragment and ligand-isoform identities are not assigned to all natural FGFR2 products. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:26267536 Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | KEEP AS NON CORE | Summary: FGFR2 associates with FGF ligands and FGFR1 in human-cell interaction networks. Reason: The genuine BioPlex networks contain exact FGFR2 pairs with FGFR1 and FGF2 in 293T cells and FGF1 in HCT116 cells. Original Methods describe tagged human baits and gene-level AP-MS network assembly. Retain protein association without claiming each pair is direct or assigning the network accession to one tested natural isoform. Supporting Evidence: PMID:33961781 2021 May 6. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | KEEP AS NON CORE | Summary: FGFR2 associates with FGFR1 and FGF2 in human-cell receptor interaction experiments. Reason: Original Results/Methods and exact interaction records support FGFR1 co-immunoprecipitation and FGFR1/FGF2 AP-MS association with FGFR2 in tagged human-cell assays. The GRB2 record is BioID proximity and is not treated as direct affinity. Supported protein association is retained as non-core. Supporting Evidence: PMID:35384245 Physical and functional interactome atlas of human receptor tyrosine kinases. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005515 protein binding | IPI PMID:35922511 A physical wiring diagram for the human immune system. | UNDECIDED | Summary: The FGFR2–FCER2 screen signal has unresolved interaction specificity. Reason: The original FCER2–FGFR2 pair is present in author Tables 1/2 and Figure 1 source data. However, the actual screening Methods name FGFRs among recurrent nonspecific candidates, and pair-specific orthogonal validation was not verified. The remaining uncertainty is interaction specificity, not failure to locate the target table. Supporting Evidence: PMID:35922511 Aug 3. A physical wiring diagram for the human immune system. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0001837 epithelial to mesenchymal transition | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to epithelial to mesenchymal transition. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0001837 (IDA PMID:7803853). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0003416 endochondral bone growth | IEA GO_REF:0000107 | ACCEPT | Summary: FGFR2 signaling contributes to endochondral bone growth. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0003416 (IEP PMID:17169623). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0009986 cell surface | IEA GO_REF:0000107 | ACCEPT | Summary: Membrane FGFR2 reaches the cell surface. Reason: The rat Fgfr2 F1LSG7 donor has matching cell-surface annotations. Independent human evidence also supports the generic receptor location: PMID:16597614 reports receptor surface microscopy and PMID:1697263 describes cell-surface BEK. This core location does not newly verify every donor experiment or assign the location to all soluble splice products. |
| GO:0017134 fibroblast growth factor binding | IEA GO_REF:0000120 | ACCEPT | Summary: FGFR2 binds fibroblast growth factors. Reason: The fibroblast growth factor binding mapping is consistent with the target kinase/receptor architecture and retained receptor evidence. Actual target InterPro matches, UniProt mappings and applicable ARBA conditions are distinguished in the source guide; none establishes all-product equivalence. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0032496 response to lipopolysaccharide | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rat Fgfr2 has a reported expression response to lipopolysaccharide. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0032496 (IEP PMID:19524256). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0044344 cellular response to fibroblast growth factor stimulus | IEA GO_REF:0000107 | ACCEPT | Summary: Rat Fgfr2 has a reported expression response to fibroblast growth factor stimulus. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0044344 (IEP PMID:9373031, IMP PMID:28981091). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0045471 response to ethanol | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rat Fgfr2 has a reported expression response to ethanol. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0045471 (IEP PMID:16770775). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048333 mesodermal cell differentiation | IEA GO_REF:0000107 | ACCEPT | Summary: FGFR2 signaling contributes to mesodermal cell differentiation. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0048333 (IEP PMID:7803853). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0050680 negative regulation of epithelial cell proliferation | IEA GO_REF:0000120 | UNDECIDED | Summary: The electronic claim that FGFR2 suppresses epithelial proliferation remains unresolved. Reason: The current combined mapping includes ARBA00089537, whose present conditions do not match the saved target feature set. Historical rule conditions and the specific inhibitory epithelial context remain unresolved. Positive proliferation elsewhere does not exclude context-dependent negative regulation. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0071300 cellular response to retinoic acid | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rat Fgfr2 has a reported expression response to retinoic acid. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0071300 (IEP PMID:15389522). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0071456 cellular response to hypoxia | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rat Fgfr2 has a reported expression response to hypoxia. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0071456 (IEP PMID:31093967). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0071560 cellular response to transforming growth factor beta stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Rat Fgfr2 has a reported expression response to transforming growth factor beta stimulus. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:0071560 (IEP PMID:12648559). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Expression response supports a response claim, not a demonstrated signaling-effector mechanism. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: FGFR2 signaling promotes vascular associated smooth muscle cell proliferation. Reason: The exact rat Fgfr2 donor F1LSG7 carries GO:1904707 (IMP PMID:15292181). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0009986 cell surface | IDA PMID:17959718 Heparanase cleavage of perlecan heparan sulfate modulates FG... | ACCEPT | Summary: FGFR2 functions as a cell-surface FGF receptor. Reason: Independent human target evidence supports the generic cell-surface claim: PMID:16597614 reports receptor microscopy and PMID:1697263 describes cell-surface BEK. PMID:17959718 itself uses mouse gland explants and a recombinant mouse FGFR2b–human Fc probe, not an endogenous human receptor-localization assay. The imported claim is retained with curator deference without relabelling that experiment. Supporting Evidence: PMID:17959718 Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654748 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654748 participant response contains P21802-family reference entities in physical entities 5654745, 5654747. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655233 participant response contains P21802-family reference entities in physical entities 5655236, 5655345. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655241 participant response contains P21802-family reference entities in physical entities 5655345. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655245 participant response contains P21802-family reference entities in physical entities 5655330, 5655337. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655268 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655268 participant response contains P21802-family reference entities in physical entities 5655257, 5655236. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655301 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655301 participant response contains P21802-family reference entities in physical entities 5655346, 5654745. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655320 participant response contains P21802-family reference entities in physical entities 5655236, 5655330. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655323 participant response contains P21802-family reference entities in physical entities 5655337. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655339 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655339 participant response contains P21802-family reference entities in physical entities 5654747, 5655257. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655343 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5655343 participant response contains P21802-family reference entities in physical entities 5654747, 5655346. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8853313 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-8853313 participant response contains P21802-family reference entities in physical entities 8853264, 8853275. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0010839 negative regulation of keratinocyte proliferation | IMP PMID:21412257 MiR-125b, a microRNA downregulated in psoriasis, modulates k... | UNDECIDED | Summary: The reported suppression of keratinocyte proliferation by FGFR2 remains unresolved. Reason: The abstract reports reduced keratinocyte proliferation after FGFR2 knockdown, but the complete experimental context was not recovered. That abstract does not justify rejecting a curator-read negative-regulation assertion or substituting a positive term. Supporting Evidence: PMID:21412257 Mar 17. MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8853319 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-8853319 participant response contains P21802-family reference entities in physical entities 8853265, 8853264. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2029989 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2029989 participant response contains P21802-family reference entities in physical entities 2029963, 2029940. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2029983 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2029983 participant response contains P21802-family reference entities in physical entities 2029955, 2029952. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2029984 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2029984 participant response contains P21802-family reference entities in physical entities 2029952, 2029948. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033472 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2033472 participant response contains P21802-family reference entities in physical entities 2033375, 2065986. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033474 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2033474 participant response contains P21802-family reference entities in physical entities 2033371, 2065929. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033479 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2033479 participant response contains P21802-family reference entities in physical entities 2033351, 2033349. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033486 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2033486 participant response contains P21802-family reference entities in physical entities 2065986, 2065989. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033488 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2033488 participant response contains P21802-family reference entities in physical entities 2065929, 2065931. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033490 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2033490 participant response contains P21802-family reference entities in physical entities 2033349, 2033348. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2077424 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2077424 participant response contains P21802-family reference entities in physical entities 2077401, 2077404. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-109699 participant response contains P21802-family reference entities in physical entities 188019. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. A target-containing complex is labelled cytosol, so the plasma-membrane assignment is supported by the independently established receptor location, not by treating every complex component as having the complex compartment. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190413 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-190413 participant response contains P21802-family reference entities in physical entities 192594, 192616. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2316434 participant response contains P21802-family reference entities in physical entities 2316432. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2400009 participant response contains P21802-family reference entities in physical entities 2400011, 2400008. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. A target-containing complex is labelled cytosol, so the plasma-membrane assignment is supported by the independently established receptor location, not by treating every complex component as having the complex compartment. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654147 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654147 participant response contains P21802-family reference entities in physical entities 5654162, 5654150. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654157 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654157 participant response contains P21802-family reference entities in physical entities 5654150, 5654152. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654159 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654159 participant response contains P21802-family reference entities in physical entities 5654152, 5654162. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654397 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654397 participant response contains P21802-family reference entities in physical entities 5654178, 5654201, 5654281. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654399 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654399 participant response contains P21802-family reference entities in physical entities 5654152, 5654178. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654402 participant response contains P21802-family reference entities in physical entities 5654296. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654404 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654404 participant response contains P21802-family reference entities in physical entities 5654152, 5654279. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654406 participant response contains P21802-family reference entities in physical entities 5654294, 5654296. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654407 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654407 participant response contains P21802-family reference entities in physical entities 5654279, 5654294. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654562 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654562 participant response contains P21802-family reference entities in physical entities 5654178, 5654281. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654603 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654603 participant response contains P21802-family reference entities in physical entities 5654152, 5654277. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654605 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654605 participant response contains P21802-family reference entities in physical entities 5654277, 5654284. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654607 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654607 participant response contains P21802-family reference entities in physical entities 5654290, 5654291. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654608 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654608 participant response contains P21802-family reference entities in physical entities 5654283, 5654290. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654612 participant response contains P21802-family reference entities in physical entities 5654201, 5654189. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654614 participant response contains P21802-family reference entities in physical entities 5654189, 5654190. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654615 participant response contains P21802-family reference entities in physical entities 5654283, 5654287. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654618 participant response contains P21802-family reference entities in physical entities 5654287. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654620 participant response contains P21802-family reference entities in physical entities 5654184, 5654194. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654622 participant response contains P21802-family reference entities in physical entities 5654194, 5654192. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654677 participant response contains P21802-family reference entities in physical entities 5654286, 5654360. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654697 participant response contains P21802-family reference entities in physical entities 5654192. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654701 participant response contains P21802-family reference entities in physical entities 5654190. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5654729 participant response contains P21802-family reference entities in physical entities 5654184, 5654286. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-5672965 participant response contains P21802-family reference entities in physical entities 5672601. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190258 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-190258 participant response contains P21802-family reference entities in physical entities 192596, 192594. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190260 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-190260 participant response contains P21802-family reference entities in physical entities 192604, 192615. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190408 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-190408 participant response contains P21802-family reference entities in physical entities 192615, 192606. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-8853328 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-NUL-8853328 participant response contains P21802-family reference entities in physical entities 8851704, 8853170. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. This model includes mutant, fusion or mixed-species context and is not a blanket assertion about all natural human products. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2029988 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2029988 participant response contains P21802-family reference entities in physical entities 2029960, 2029963. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2029992 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2029992 participant response contains P21802-family reference entities in physical entities 2029963, 2029966. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2067713 | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Reactome R-HSA-2067713 participant response contains P21802-family reference entities in physical entities 2029963, 2067714. Retain the plasma-membrane receptor location; the event title does not assign its downstream enzyme activity to FGFR2. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048701 embryonic cranial skeleton morphogenesis | IMP PMID:7874170 Jackson-Weiss and Crouzon syndromes are allelic with mutatio... | UNDECIDED | Summary: FGFR2 variants are associated with craniosynostosis; the embryonic cranial-process scope remains unresolved. Reason: The PMID:7874170 abstract positively associates FGFR2 variants with craniosynostosis. GO:0048701 specifically requires generation and organization of the cranial skeleton during the embryonic phase; the accessible clinical association does not resolve that stage-specific process or its experimental basis. The original full source remains unread and its erratum scope unresolved. This uncertainty does not negate the independently supported role of FGFR2 in skeletal development. Supporting Evidence: PMID:7874170 We now report an FGFR2 mutation in the conserved region of the immunoglobulin IIIc domain in the Jackson-Weiss syndrome family in which the syndrome was originally described. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048701 embryonic cranial skeleton morphogenesis | IMP PMID:7987400 Mutations in the fibroblast growth factor receptor 2 gene ca... | UNDECIDED | Summary: FGFR2 variants are associated with Crouzon syndrome; the embryonic cranial-process scope remains unresolved. Reason: The PMID:7987400 abstract positively associates FGFR2 variants with craniosynostosis. GO:0048701 specifically requires generation and organization of the cranial skeleton during the embryonic phase; the accessible clinical association does not resolve that stage-specific process or its experimental basis. The original full source remains unread. This uncertainty does not negate the independently supported role of FGFR2 in skeletal development. Supporting Evidence: PMID:7987400 We now present evidence that mutations in the fibroblast growth factor receptor 2 gene (FGFR2) cause Crouzon syndrome. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005634 nucleus | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | KEEP AS NON CORE | Summary: FGFR2 is reported in nuclei of human urothelial cells. Reason: The PMID:16597614 abstract explicitly reports microscopy detecting the FGF10 receptor within nuclei in a human urothelial model. The contextual localization is retained with curator deference; original antibody controls, images and receptor-processing details remain unread. Supporting Evidence: PMID:16597614 Deconvolution, light and transmission electron microscopic studies captured FGF-10 and its receptor in association with the urothelial cell surface, in cytoplasm, and within nuclei file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005737 cytoplasm | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | KEEP AS NON CORE | Summary: FGFR2 is reported in the cytoplasm of human urothelial cells. Reason: PMID:16597614 explicitly reports cytoplasmic receptor localization in a human urothelial model. This supports the contextual compartment with curator deference; its current grouped cell/tissue metadata is preserved in the evidence index. Original imaging controls and product details remain unread, and the cytoplasm is not asserted as the principal receptor signaling site. Supporting Evidence: PMID:16597614 Deconvolution, light and transmission electron microscopic studies captured FGF-10 and its receptor in association with the urothelial cell surface, in cytoplasm, and within nuclei file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0009986 cell surface | IDA PMID:16597614 FGF-10 and its receptor exhibit bidirectional paracrine targ... | ACCEPT | Summary: FGFR2 is observed at the human urothelial cell surface. Reason: The PMID:16597614 abstract explicitly reports receptor surface microscopy in a human urothelial model. This supports the generic cell-surface receptor location, also established by human BEK binding in PMID:1697263. Current source metadata retains grouped cell/tissue context in the evidence index; no universal tissue or natural-product localization is inferred. Complete original images and receptor-processing details remain unread. Supporting Evidence: PMID:16597614 Deconvolution, light and transmission electron microscopic studies captured FGF-10 and its receptor in association with the urothelial cell surface file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005007 fibroblast growth factor receptor activity | IDA PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: KGFR/FGFR2b couples ligand recognition to receptor signaling. Reason: The PMID:15629145 abstract reports receptor Y769-mutant effects on signaling. Independently read human FGFR2b mitogenic experiments support the established receptor function. The IDA is retained with curator deference; complete original Methods and exact construct provenance remain unread. Supporting Evidence: PMID:15629145 KGFR is rapidly autophosphorylated on specific tyrosine residues in the intracellular domain, recruits substrate proteins file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005007 fibroblast growth factor receptor activity | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGFR2 binds FGFs and transmits signals across the plasma membrane. Reason: Original PMID8663044 Table I and Methods identify human FGFR2b and mouse FGFR2c expressed in murine BaF3 cells; Figure 1, Figure 3 and Table II support surface ligand recognition and receptor-dependent mitogenesis. FGF1 is shared across the b/c forms. This supports the receptor role with species, construct and assay boundaries, not mutually exclusive ligand recognition or all-product equivalence. Supporting Evidence: PMID:8663044 we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. We have assayed the mitogenic activity of the nine known FGF ligands on these cell lines. |
| GO:0005886 plasma membrane | IDA PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: Membrane KGFR/FGFR2b undergoes ligand-dependent signaling and endocytosis. Reason: The PMID:15629145 abstract describes ligand binding and receptor internalization and compares the Y769 mutant endocytic response. Independently read FGFR2 surface/trafficking experiments support the membrane location. The IDA is retained with curator deference, without claiming that its original images or construct were re-read. Supporting Evidence: PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005886 plasma membrane | IDA PMID:16844695 Intracellular retention, degradation, and signaling of glyco... | ACCEPT | Summary: FGFR2 is a plasma-membrane receptor. Reason: Original PMID16844695 Methods and Results/Figures 1–5 and 7–10 use human FGFR2IIIc and engineered glycosylation/C278F constructs in MC3T3-E1 and COS7 cells. Surface localization, receptor dimerization and phosphorylation/PLCG1 readouts support the retained receptor mechanism; mutant intracellular retention and effects vary with cellular context and are not natural-splice functions. Supporting Evidence: PMID:16844695 we show that trafficking and autoactivation of wild type FGFR2 is glycosylation-dependent |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: KGFR signaling promotes cell proliferation through a Y769-dependent response. Reason: The PMID:15629145 abstract explicitly reports Y769-dependent proliferative signaling linked to FRS2 phosphorylation. This positive result is corroborated by independently read FGFR2b mitogenic experiments. NIH3T3 and HeLa are the reported recipients; complete construct and assay Methods remain unread. Supporting Evidence: PMID:15629145 tyrosine 769 is required...for cell proliferation through the regulation of FRS2 tyrosine phosphorylation file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008284 positive regulation of cell population proliferation | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGFR2 signaling promotes cell population proliferation. Reason: Original PMID8663044 Table I and Methods identify human FGFR2b and mouse FGFR2c expressed in murine BaF3 cells; Figure 1, Figure 3 and Table II support surface ligand recognition and receptor-dependent mitogenesis. FGF1 is shared across the b/c forms. This supports the receptor role with species, construct and assay boundaries, not mutually exclusive ligand recognition or all-product equivalence. Supporting Evidence: PMID:8663044 Receptor specificity of the fibroblast growth factor family. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: KGFR transmits FGF signals through PLCG, FRS2 and MAPK pathways. Reason: The PMID:15629145 abstract reports receptor Y769-mutant effects on PLCG association/phosphorylation, FRS2 phosphorylation and MAPK activation. These directly support the signaling claim. The IDA is retained with curator deference; no full Methods read or universal isoform behavior is claimed. Supporting Evidence: PMID:15629145 tyrosine 769 is required for the binding to KGFR and tyrosine phosphorylation of PLCgamma as well as for the full activation of MAPKs file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGFR2 transduces signals from extracellular FGF ligands. Reason: Original PMID8663044 Table I and Methods identify human FGFR2b and mouse FGFR2c expressed in murine BaF3 cells; Figure 1, Figure 3 and Table II support surface ligand recognition and receptor-dependent mitogenesis. FGF1 is shared across the b/c forms. This supports the receptor role with species, construct and assay boundaries, not mutually exclusive ligand recognition or all-product equivalence. Supporting Evidence: PMID:8663044 Receptor specificity of the fibroblast growth factor family. |
| GO:0010518 positive regulation of phospholipase activity | IMP PMID:16844695 Intracellular retention, degradation, and signaling of glyco... | ACCEPT | Summary: FGFR2 signaling promotes phospholipase activity. Reason: Original PMID16844695 Methods and Results/Figures 1–5 and 7–10 use human FGFR2IIIc and engineered glycosylation/C278F constructs in MC3T3-E1 and COS7 cells. Surface localization, receptor dimerization and phosphorylation/PLCG1 readouts support the retained receptor mechanism; mutant intracellular retention and effects vary with cellular context and are not natural-splice functions. Supporting Evidence: PMID:16844695 Both FGFR2C278F and unglycosylated wild type FGFR2 signal through phospholipase Cgamma in a ligand-independent manner |
| GO:0017134 fibroblast growth factor binding | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGFR2 binds fibroblast growth factors. Reason: Original PMID8663044 Table I and Methods identify human FGFR2b and mouse FGFR2c expressed in murine BaF3 cells; Figure 1, Figure 3 and Table II support surface ligand recognition and receptor-dependent mitogenesis. FGF1 is shared across the b/c forms. This supports the receptor role with species, construct and assay boundaries, not mutually exclusive ligand recognition or all-product equivalence. Supporting Evidence: PMID:8663044 FGF 1 is the only FGF that can activate all FGF receptor splice variants |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: Activated KGFR supports tyrosine phosphorylation of signaling proteins. Reason: The PMID:15629145 abstract links the receptor Y769 site to PLCG and FRS2 tyrosine-phosphorylation readouts. This supports the process annotation without establishing that every downstream phosphorylation was catalyzed directly by FGFR2. Original assay Methods remain unread. Supporting Evidence: PMID:15629145 tyrosine 769 is required for the binding to KGFR and tyrosine phosphorylation of PLCgamma...through the regulation of FRS2 tyrosine phosphorylation file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0018108 peptidyl-tyrosine phosphorylation | IDA PMID:16844695 Intracellular retention, degradation, and signaling of glyco... | ACCEPT | Summary: FGFR2 signaling promotes protein tyrosine phosphorylation. Reason: Original PMID16844695 Methods and Results/Figures 1–5 and 7–10 use human FGFR2IIIc and engineered glycosylation/C278F constructs in MC3T3-E1 and COS7 cells. Surface localization, receptor dimerization and phosphorylation/PLCG1 readouts support the retained receptor mechanism; mutant intracellular retention and effects vary with cellular context and are not natural-splice functions. Supporting Evidence: PMID:16844695 2006 Jul 14. Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. |
| GO:0033688 regulation of osteoblast proliferation | TAS PMID:15190072 Cbl-mediated degradation of Lyn and Fyn induced by constitut... | KEEP AS NON CORE | Summary: FGFR2 signaling regulates osteoblast proliferation in a developmental context. Reason: The generic regulatory claim is retained with curator deference and the independently inspected P21802 UniProt FUNCTION statement explicitly describing osteoblast proliferation. PMID:15190072 establishes human mutant-osteoblast differentiation, alkaline-phosphatase and CBL/Lyn/Fyn responses; its separate proliferation endpoint remains unread. Those target-cell findings corroborate the context but are not presented as a newly verified proliferation assay. Supporting Evidence: PMID:15190072 Fibroblast growth factors (FGFs) play an important regulatory role in skeletal development and bone formation file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0042803 protein homodimerization activity | IPI PMID:16844695 Intracellular retention, degradation, and signaling of glyco... | ACCEPT | Summary: FGFR2 can form receptor homodimers. Reason: Original PMID16844695 Methods and Results/Figures 1–5 and 7–10 use human FGFR2IIIc and engineered glycosylation/C278F constructs in MC3T3-E1 and COS7 cells. Surface localization, receptor dimerization and phosphorylation/PLCG1 readouts support the retained receptor mechanism; mutant intracellular retention and effects vary with cellular context and are not natural-splice functions. Supporting Evidence: PMID:16844695 2006 Jul 14. Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. |
| GO:0043410 positive regulation of MAPK cascade | IMP PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: KGFR signaling promotes MAPK activation. Reason: The PMID:15629145 abstract states that the receptor Y769 site is required for full MAPK activation. This supports the regulatory annotation without implying direct FGFR2 phosphorylation of MAPKs. Complete original Methods remain unread. Supporting Evidence: PMID:15629145 tyrosine 769 is required...for the full activation of MAPKs file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0045667 regulation of osteoblast differentiation | TAS PMID:15190072 Cbl-mediated degradation of Lyn and Fyn induced by constitut... | KEEP AS NON CORE | Summary: Constitutively active FGFR2 alters human osteoblast differentiation. Reason: The PMID:15190072 abstract reports human FGFR2 S252W osteoblasts with altered Lyn/Fyn activity and alkaline phosphatase, including CBL/Src-pathway interventions. This supports contextual differentiation, not a universal direction for normal FGFR2 or a precise embryonic cranial-stage mechanism. Complete Methods remain unread. Supporting Evidence: PMID:15190072 constitutive FGFR2 activation induces c-Cbl-dependent Lyn and Fyn proteasome degradation, resulting in...increased ALP expression file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0046777 protein autophosphorylation | IDA PMID:15629145 Tyrosine 769 of the keratinocyte growth factor receptor is r... | ACCEPT | Summary: Ligand-activated KGFR undergoes tyrosine autophosphorylation. Reason: The PMID:15629145 abstract describes KGFR autophosphorylation and investigates a receptor phosphotyrosine site. The activity is independently supported by read FGFR2 phosphorylation experiments. The IDA is retained with curator deference; no new full-text assay verification is claimed. Supporting Evidence: PMID:15629145 KGFR is rapidly autophosphorylated on specific tyrosine residues in the intracellular domain file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048705 skeletal system morphogenesis | TAS PMID:15190072 Cbl-mediated degradation of Lyn and Fyn induced by constitut... | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to skeletal system morphogenesis. Reason: The broad skeletal claim is retained with curator deference and independent positive human craniosynostosis genetics in PMID:7987400 and PMID:7874170, alongside the curated UniProt skeleton-development statement. PMID:15190072 itself reports mutant-osteoblast differentiation and ALP/CBL/Lyn/Fyn responses; its tissue-level morphogenesis endpoint remains unread. No precise embryonic stage is inferred from the disease association. Supporting Evidence: PMID:15190072 Fibroblast growth factors (FGFs) play an important regulatory role in skeletal development and bone formation file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling supports bone-marrow cell survival. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0035602 (IMP PMID:20345253). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0035603 fibroblast growth factor receptor signaling pathway involved in hemopoiesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to hematopoiesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0035603 (IMP PMID:20345253). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0035604 fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling promotes bone-marrow cell proliferation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0035604 (IMP PMID:20345253). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to orbitofrontal cortex development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0035607 (IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0021769 orbitofrontal cortex development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to orbitofrontal cortex development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0021769 (IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0021847 ventricular zone neuroblast division | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to ventricular zone neuroblast division. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0021847 (IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0021860 pyramidal neuron development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to pyramidal neuron development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0021860 (IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0045787 positive regulation of cell cycle | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling promotes cell-cycle progression. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0045787 (IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060076 excitatory synapse | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: An ortholog-derived annotation places FGFR2 at excitatory synapses. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060076 (IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0000122 negative regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling can restrain transcription by RNA polymerase II. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0000122 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0001525 angiogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to angiogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0001525 (IBA GO_REF:0000033, IGI PMID:16778080). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0001657 ureteric bud development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to ureteric bud development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0001657 (IGI PMID:16442091). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0001701 in utero embryonic development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to in utero embryonic development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0001701 (IGI PMID:17687036, IMP PMID:9435295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0002053 positive regulation of mesenchymal cell proliferation | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling promotes mesenchymal cell proliferation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0002053 (IGI PMID:16540513). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0003148 outflow tract septum morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to outflow tract septum morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0003148 (IMP PMID:16687131). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0003149 membranous septum morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to membranous septum morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0003149 (IMP PMID:16687131). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0007267 cell-cell signaling | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to cell-cell signaling. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0007267 (IMP PMID:15199404). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0007409 axonogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to axonogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0007409 (IMP PMID:17951031). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008589 regulation of smoothened signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling modulates the Smoothened pathway. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0008589 (IMP PMID:16618415). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0009791 post-embryonic development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to post-embryonic development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0009791 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0009880 embryonic pattern specification | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to embryonic pattern specification. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0009880 (IMP PMID:16618415). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0009887 animal organ morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to animal organ morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0009887 (IMP PMID:12666202). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0016331 morphogenesis of embryonic epithelium | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to morphogenesis of embryonic epithelium. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0016331 (IMP PMID:15843416). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0022612 gland morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to gland morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0022612 (IMP PMID:17202188). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0030177 positive regulation of Wnt signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling promotes Wnt-pathway activation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0030177 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0030282 bone mineralization | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to bone mineralization. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0030282 (IMP PMID:12756187). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0030324 lung development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to lung development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0030324 (IEA GO_REF:0000117, IGI PMID:16540513, IMP PMID:10518547). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0030855 epithelial cell differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to epithelial cell differentiation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0030855 (IEA GO_REF:0000117, IMP PMID:16618415). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0030901 midbrain development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to midbrain development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0030901 (IEA GO_REF:0000117, IGI PMID:17687036). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0030916 otic vesicle formation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to otic vesicle formation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0030916 (IMP PMID:9435295, TAS PMID:22235191). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0031069 hair follicle morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to hair follicle morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0031069 (IMP PMID:14530295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0032808 lacrimal gland development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to lacrimal gland development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0032808 (IMP PMID:10821755). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0035265 organ growth | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to organ growth. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0035265 (IMP PMID:16618415). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0042472 inner ear morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to inner ear morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0042472 (IMP PMID:10934262). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0042476 odontogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to odontogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0042476 (IMP PMID:17951031). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0045165 cell fate commitment | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to cell fate commitment. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0045165 (IDA PMID:15509736, IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0045944 positive regulation of transcription by RNA polymerase II | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling promotes transcription by RNA polymerase II. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0045944 (IMP PMID:16989802, IMP PMID:20410112). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048286 lung alveolus development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to lung alveolus development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048286 (IGI PMID:16989802, IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048557 embryonic digestive tract morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to embryonic digestive tract morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048557 (IMP PMID:16618415, IMP PMID:21492869, IMP PMID:21550054). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048562 embryonic organ morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to embryonic organ morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048562 (IEA GO_REF:0000117, IMP PMID:15843416). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048565 digestive tract development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to digestive tract development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048565 (IMP PMID:15234214). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048568 embryonic organ development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to embryonic organ development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048568 (IMP PMID:9435295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048608 reproductive structure development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to reproductive structure development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048608 (IMP PMID:12666202). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048730 epidermis morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to epidermis morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048730 (IMP PMID:14530295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048755 branching morphogenesis of a nerve | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to branching morphogenesis of a nerve. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048755 (IMP PMID:17951031). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0048762 mesenchymal cell differentiation | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to mesenchymal cell differentiation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0048762 (IGI PMID:16442091). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0050679 positive regulation of epithelial cell proliferation | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling promotes epithelial cell proliferation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0050679 (IGI PMID:15972105, IMP PMID:15843416). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0051150 regulation of smooth muscle cell differentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling modulates smooth muscle cell differentiation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0051150 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0051781 positive regulation of cell division | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling promotes cell division. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0051781 (IMP PMID:14530295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0055010 ventricular cardiac muscle tissue morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to ventricular cardiac muscle tissue morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0055010 (IMP PMID:16687131). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060045 positive regulation of cardiac muscle cell proliferation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling promotes cardiac muscle cell proliferation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060045 (IGI PMID:15621532). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060174 limb bud formation | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to limb bud formation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060174 (IMP PMID:10518547, IMP PMID:9435295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060348 bone development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to bone development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060348 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060349 bone morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to bone morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060349 (IMP PMID:10518547). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060442 branching involved in prostate gland morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to branching of the developing prostate. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060442 (IMP PMID:12666202, IMP PMID:17202188, IMP PMID:17215304). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060445 branching involved in salivary gland morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to salivary-gland branching. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060445 (IMP PMID:11731698). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060449 bud elongation involved in lung branching | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling supports bud elongation during lung branching. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060449 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060463 lung lobe morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to lung-lobe formation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060463 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060484 lung-associated mesenchyme development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to lung-associated mesenchyme development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060484 (IGI PMID:18533146, IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling promotes epithelial proliferation during lung morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060501 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060512 prostate gland morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to prostate gland morphogenesis. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060512 (IMP PMID:18184727). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060523 prostate epithelial cord elongation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to prostate epithelial-cord elongation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060523 (IMP PMID:17215304). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to epithelial-cord branching during prostate acinus formation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060527 (IMP PMID:17215304). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to basal epithelial stem-cell differentiation during prostate acinus development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060529 (IMP PMID:17215304). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060601 lateral sprouting from an epithelium | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to lateral epithelial sprouting. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060601 (IMP PMID:12666202). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060615 mammary gland bud formation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to mammary gland bud formation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060615 (IMP PMID:11782400). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to epithelial proliferation during salivary-gland formation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060664 (IGI PMID:15972105, IMP PMID:15972105). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060667 branch elongation involved in salivary gland morphogenesis | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to salivary-gland branch elongation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060667 (IGI PMID:15972105, IMP PMID:15972105). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060670 branching involved in labyrinthine layer morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling contributes to branching in the placental labyrinthine layer. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060670 (IMP PMID:9435295). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060688 regulation of morphogenesis of a branching structure | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling modulates morphogenesis of a branching structure. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060688 (IMP PMID:17202188). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060915 mesenchymal cell differentiation involved in lung development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to mesenchymal differentiation during lung development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060915 (IGI PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0060916 mesenchymal cell proliferation involved in lung development | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling contributes to mesenchymal proliferation during lung development. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0060916 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0070372 regulation of ERK1 and ERK2 cascade | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling modulates the ERK1/ERK2 cascade. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0070372 (IMP PMID:16989802). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | ISS GO_REF:0000024 | ACCEPT | Summary: FGFR2 signaling promotes ERK1/ERK2-cascade activation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0070374 (IGI PMID:17202188). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain its contribution to the receptor signaling/developmental role without assigning it to every splice product. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0090263 positive regulation of canonical Wnt signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: FGFR2 signaling promotes canonical Wnt-pathway activation. Reason: The exact mouse Fgfr2 donor P21803 carries GO:0090263 (IGI PMID:18533146, IMP PMID:16720875). This supports the imported ortholog inference; the original donor experiments were not independently re-read here, and the source is not a human assay. Retain the specified tissue, developmental or response context as non-core; specificity alone is not evidence of an erroneous transfer. Supporting Evidence: file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0016020 membrane | NAS PMID:8676562 [Nucleotide sequences at intron 6 and exon 7 junction of fib... | ACCEPT | Summary: The membrane-spanning FGFR2 receptor is membrane-associated. Reason: The PMID:8676562 abstract describes clinical mutation detection, not a membrane assay. NAS does not assert such a direct assay. The generic membrane claim is retained with curator deference and independently read FGFR2 surface-receptor evidence, without attributing that experiment to this clinical paper. Supporting Evidence: PMID:8676562 Apert syndrome, acrocephalosyndactyly Type I, is an autosomal dominant craniosynostosis comprising acrocephaly, facial dysmorphism and severe syndactyly of the hands and feet. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005634 nucleus | IDA PMID:17471512 Translocation of fibroblast growth factor-10 and its recepto... | KEEP AS NON CORE | Summary: The FGF10 receptor is observed in nuclei of human urothelial cells. Reason: The PMID:17471512 abstract explicitly reports receptor nuclear localization independent of added FGF10 concentration. Its ligand nuclear-localization mutants are not FGFR2 products. Original receptor-antibody controls and images remain unread. Supporting Evidence: PMID:17471512 The FGF-10 receptor was observed in cell nuclei regardless of the presence or concentration of exogenous rFGF-10 ligand file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005737 cytoplasm | IDA PMID:17471512 Translocation of fibroblast growth factor-10 and its recepto... | KEEP AS NON CORE | Summary: FGFR2 has a contextual cytoplasmic receptor pool. Reason: Independent human receptor microscopy in PMID:16597614 supports the generic cytoplasm claim, retained with curator deference. In PMID:17471512, the reported cytoplasmic redistribution concerns an FGF10 ligand variant, whereas the receptor is explicitly observed in nuclei. That experiment is not reinterpreted as receptor cytoplasmic localization; its original receptor-compartment details remain unread. Supporting Evidence: PMID:17471512 rFGF-10(no NLS) was found in cytoplasm to a far greater degree than rFGF-10 file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005938 cell cortex | IDA PMID:17471512 Translocation of fibroblast growth factor-10 and its recepto... | UNDECIDED | Summary: The receptor cell-cortex localization claim remains unresolved in this source. Reason: The PMID:17471512 abstract explicitly reports receptor nuclear localization; its redistribution experiment concerns FGF10 ligand. Receptor cell-cortex localization and the relevant original images remain unverified. This access/scope limit does not establish that the curated receptor annotation is false. Supporting Evidence: PMID:17471512 Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGFR2 signaling promotes cell population proliferation. Reason: Original PMID8663044 Table I and Methods identify human FGFR2b and mouse FGFR2c expressed in murine BaF3 cells; Figure 1, Figure 3 and Table II support surface ligand recognition and receptor-dependent mitogenesis. FGF1 is shared across the b/c forms. This supports the receptor role with species, construct and assay boundaries, not mutually exclusive ligand recognition or all-product equivalence. Supporting Evidence: PMID:8663044 Receptor specificity of the fibroblast growth factor family. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGFR2 transduces signals from extracellular FGF ligands. Reason: Original PMID8663044 Table I and Methods identify human FGFR2b and mouse FGFR2c expressed in murine BaF3 cells; Figure 1, Figure 3 and Table II support surface ligand recognition and receptor-dependent mitogenesis. FGF1 is shared across the b/c forms. This supports the receptor role with species, construct and assay boundaries, not mutually exclusive ligand recognition or all-product equivalence. Supporting Evidence: PMID:8663044 Receptor specificity of the fibroblast growth factor family. |
| GO:0005007 fibroblast growth factor receptor activity | IGI PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the dete... | ACCEPT | Summary: FGFR2 recognizes FGF ligands through its extracellular domains. Reason: The PMID:10830168 abstract reports the FGF2–FGFR2 recognition complex. Curator deference plus independently read ligand-responsive FGFR2 experiments support receptor activity. The structure alone does not demonstrate signal transmission; original genetic assay and construct details remain unread. Supporting Evidence: PMID:10830168 Specificity is achieved through interactions between the N-terminal and central regions of FGFs and two loop regions in D3 that are subject to alternative splicing file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IPI PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the dete... | ACCEPT | Summary: FGF recognition by FGFR2 initiates receptor signaling. Reason: The source abstract establishes the FGF2–FGFR2 recognition complex, a physical step of FGFR signaling. The IPI pathway annotation is retained with curator deference and independent receptor-signaling evidence; the structural abstract is not claimed to measure every downstream step. Supporting Evidence: PMID:10830168 Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0017134 fibroblast growth factor binding | IPI PMID:8386828 Activation of fibroblast growth factor (FGF) receptors by re... | ACCEPT | Summary: Human FGFR2 binds FGF5 with nanomolar affinity. Reason: The PMID:8386828 abstract explicitly reports human FGFR2 binding/autophosphorylation and an FGF5–FGFR2 dissociation constant of 0.5–1.5 nM. This directly supports FGF binding. Complete assay Methods and receptor-isoform mapping remain unread; those limits do not negate the reported measurement. Supporting Evidence: PMID:8386828 the KD for FGF-5-FGFR-1 and FGF-5-FGFR-2 interactions are both between 0.5 and 1.5 x 10(-9) M file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005007 fibroblast growth factor receptor activity | NAS PMID:8676562 [Nucleotide sequences at intron 6 and exon 7 junction of fib... | ACCEPT | Summary: FGFR2 functions as an FGF-responsive receptor tyrosine kinase. Reason: The PMID:8676562 abstract concerns clinical mutation detection rather than receptor assays. The generic NAS activity claim is retained with curator deference and independently read human FGFR2b responses and receptor biochemistry. The clinical paper is not presented as a newly verified activity experiment. Supporting Evidence: PMID:8676562 Apert syndrome, acrocephalosyndactyly Type I, is an autosomal dominant craniosynostosis comprising acrocephaly, facial dysmorphism and severe syndactyly of the hands and feet. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0004713 protein tyrosine kinase activity | NAS PMID:1697263 Cloning and expression of two distinct high-affinity recepto... | ACCEPT | Summary: FGFR2 catalyzes protein tyrosine phosphorylation. Reason: The PMID:1697263 abstract identifies the human BEK kinase domain and reports receptor binding; it does not describe a catalytic assay. The generic NAS kinase claim is retained with curator deference and independently read FGFR2 phosphorylation evidence. Complete cloning-paper Methods remain unread. Supporting Evidence: PMID:1697263 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005007 fibroblast growth factor receptor activity | NAS PMID:1400433 A novel form of fibroblast growth factor receptor 2. Alterna... | ACCEPT | Summary: Alternative FGFR2 forms recognize FGF ligands with different affinities. Reason: The PMID:1400433 abstract reports FGFR2 expression in rat L6 recipients and differential FGF1/FGF2 binding. The generic NAS receptor-activity annotation is retained with curator deference and independent signaling support. Exact construct and natural-product mapping remain unread. Supporting Evidence: PMID:1400433 A novel form of fibroblast growth factor receptor 2. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0005007 fibroblast growth factor receptor activity | NAS PMID:1697263 Cloning and expression of two distinct high-affinity recepto... | ACCEPT | Summary: Human BEK/FGFR2 binds FGFs as a cell-surface receptor. Reason: The PMID:1697263 abstract explicitly identifies human BEK expression in NIH3T3 cells and high-affinity ligand binding. Generic NAS receptor function is retained with curator deference and independent ligand-responsive signaling evidence; the abstract alone does not establish every downstream activity. Supporting Evidence: PMID:1697263 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. file:human/FGFR2/FGFR2-source-evidence.yaml |
| GO:0016020 membrane | NAS PMID:1697263 Cloning and expression of two distinct high-affinity recepto... | ACCEPT | Summary: Human BEK/FGFR2 contains a transmembrane segment and reaches the cell surface. Reason: The PMID:1697263 abstract explicitly describes cloned human BEK as a cell-surface receptor with a single transmembrane domain. This supports the generic NAS membrane claim, corroborated by independently read FGFR2 trafficking evidence. Original images and detailed Methods were not re-read. Supporting Evidence: PMID:1697263 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. file:human/FGFR2/FGFR2-source-evidence.yaml |
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Download this section (compressed HTML)Q: Which endogenous human FGFR2 splice products mediate the documented nuclear and intracellular receptor pools, and how do their activities differ from membrane-receptor signaling? Existing localization papers and engineered retention mutants should be resolved separately from natural-product identities.
Q: What physiological functions are established for soluble P21802-14 and P21802-19? Their documented secretion does not by itself demonstrate a decoy mechanism.
Q: Does the FCER2–FGFR2 extracellular-screen association remain specific after the original study’s promiscuous-hit controls, and is there pair-specific orthogonal evidence distinct from the aggregate validation rate?
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