Fibroblast growth factor receptor 3 is a single-pass type I transmembrane receptor tyrosine kinase with three extracellular Ig-like domains (alternatively spliced IIIb/IIIc forms of D3 set ligand specificity), a transmembrane helix and a split cytoplasmic tyrosine kinase domain. At the plasma membrane, binding of FGF ligands together with heparan sulfate (and, for endocrine FGFs, Klotho co-receptors) induces receptor dimerization and trans-autophosphorylation, after which FGFR3 phosphorylates and recruits FRS2, PLCG1 and other effectors to activate RAS-ERK1/2, PLCgamma, PI3K-AKT and STAT1/3 signalling. Activated receptor is ubiquitinated, internalized and degraded. FGFR3 is the principal FGF receptor of growth-plate chondrocytes, where its signalling restrains proliferation and hypertrophic differentiation and promotes apoptosis, acting as a brake on endochondral bone growth; gain-of-function variants cause achondroplasia, hypochondroplasia and thanatophoric dysplasia, whereas partial loss of function causes tall stature and hearing loss (CATSHL). It also contributes to inner ear development and osteoblast mineralization, and activating mutations or fusions (e.g. FGFR3-TACC3) drive bladder cancer and multiple myeloma. A secreted splice isoform lacking the transmembrane domain can bind FGFs and may act as a decoy.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000165 MAPK cascade | TAS PMID:10918587 Transformation and Stat activation by derivatives of FGFR1, ... | MODIFY | Summary: Activated FGFR3 derivatives stimulate MAPK phosphorylation. Reason: FGFR3 is upstream of, not a component of, the MAPK cascade; the receptor activates the cascade. Positive regulation of MAPK cascade (GO:0043410) captures the relationship correctly. Proposed replacements: positive regulation of MAPK cascade Supporting Evidence: PMID:10918587 Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated |
| GO:0001501 skeletal system development | TAS PMID:8601314 Fibroblast growth factor receptor 3 is a negative regulator ... | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (TAS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:8601314 FGFR-3 appears to regulate endochondral ossification by an essentially negative mechanism, limiting rather than promoting osteogenesis. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0001503 ossification | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (IEA). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:15748888 Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0001958 endochondral ossification | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (TAS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:15748888 FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0002062 chondrocyte differentiation | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | MODIFY | Summary: Review statement on FGFR3 control of chondrocyte differentiation. Reason: FGFR3-ERK signalling inhibits chondrocyte (hypertrophic) differentiation; FGFR3 is a regulator, not an executor, of differentiation. Negative regulation of chondrocyte differentiation (GO:0032331) is more accurate. Proposed replacements: negative regulation of chondrocyte differentiation Supporting Evidence: PMID:15748888 STAT1 phosphorylation seems to be involved in inhibition of chondrocyte proliferation while activation of the ERK pathway inhibits chondrocyte differentiation and B-cell proliferation |
| GO:0003416 endochondral bone growth | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (TAS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:15748888 FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0004672 protein kinase activity | IEA GO_REF:0000002 | ACCEPT | Summary: InterPro kinase domain mapping. Reason: Correct but general; FGFR3 is a tyrosine-specific protein kinase (more specific terms also annotated). Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0004713 protein tyrosine kinase activity | IDA PMID:11294897 Identification of tyrosine residues in constitutively activa... | ACCEPT | Summary: Autophosphorylation and substrate phosphorylation by constitutively active FGFR3 derivatives. Reason: Tyrosine kinase activity is demonstrated directly; correct though less specific than transmembrane receptor protein tyrosine kinase activity. Supporting Evidence: PMID:11294897 Activation of FGFR3, through mutation or ligand stimulation, results in autophosphorylation of multiple tyrosine residues within the intracellular domain. |
| GO:0004713 protein tyrosine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: Automated annotation from InterPro/RHEA. Reason: Correct; FGFR3 catalyses tyrosine phosphorylation of itself and substrates (PLCG1, FRS2, CBL). Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. |
| GO:0004714 transmembrane receptor protein tyrosine kinase activity | IEA GO_REF:0000003 | ACCEPT | Summary: EC 2.7.10.1 mapping. Reason: FGFR3 is a transmembrane receptor tyrosine kinase; the EC mapping is correct. GO:0005007 is the more specific child. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0005007 fibroblast growth factor receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference (PAINT) for the FGFR clade. Reason: FGF receptor activity (ligand-activated transmembrane receptor tyrosine kinase that transduces FGF binding into intracellular signalling) is the core molecular function of FGFR3, supported by ligand-binding, structural and cell signalling data. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0005007 fibroblast growth factor receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: Combined automated annotation (InterPro/UniRule). Reason: FGF receptor activity (ligand-activated transmembrane receptor tyrosine kinase that transduces FGF binding into intracellular signalling) is the core molecular function of FGFR3, supported by ligand-binding, structural and cell signalling data. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0005007 fibroblast growth factor receptor activity | IMP PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: Mitogenic response of engineered BaF3 cells expressing FGFR3 splice variants to FGF ligands. Reason: FGF receptor activity (ligand-activated transmembrane receptor tyrosine kinase that transduces FGF binding into intracellular signalling) is the core molecular function of FGFR3, supported by ligand-binding, structural and cell signalling data. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. PMID:8663044 These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. |
| GO:0005007 fibroblast growth factor receptor activity | TAS PMID:10918587 Transformation and Stat activation by derivatives of FGFR1, ... | ACCEPT | Summary: Traceable author statement from comparison of activated FGFR1/3/4 derivatives. Reason: FGF receptor activity (ligand-activated transmembrane receptor tyrosine kinase that transduces FGF binding into intracellular signalling) is the core molecular function of FGFR3, supported by ligand-binding, structural and cell signalling data. Supporting Evidence: PMID:10918587 Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated |
| GO:0005515 protein binding | IPI PMID:14732692 Insights into the molecular basis for fibroblast growth fact... | MODIFY | Summary: Crystal structure and SPR of FGFR3c ectodomain in complex with FGF1 (partner P05230, FGF1). Reason: The interaction is the ligand-receptor interaction itself; the informative MF is fibroblast growth factor binding (GO:0017134), which is already annotated to FGFR3 by IDA/IBA. Generic protein binding adds nothing. Proposed replacements: fibroblast growth factor binding Supporting Evidence: PMID:14732692 Here, we report the crystal structure of the three-Ig form of FGFR3c in complex with FGF1 |
| GO:0005515 protein binding | IPI PMID:16169070 A human protein-protein interaction network: a resource for ... | REMOVE | Summary: Interaction with UniProtKB:Q15486 (GUSBP1) detected in a large-scale yeast two-hybrid screen. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:16169070 was screened by automated yeast two-hybrid (Y2H) interaction mating |
| GO:0005515 protein binding | IPI PMID:22939624 Quantitative analysis of HSP90-client interactions reveals p... | REMOVE | Summary: Interaction with UniProtKB:P08238 (HSP90AB1) detected in a quantitative LUMIER survey of HSP90/CDC37 client kinases. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. HSP90/CDC37 binding reflects FGFR3 being a kinase client of the chaperone machinery (folding/maturation), not a signalling function of FGFR3. Supporting Evidence: PMID:22939624 Unexpectedly, many more kinases than transcription factors bound HSP90. |
| GO:0005515 protein binding | IPI PMID:25036637 A quantitative chaperone interaction network reveals the arc... | REMOVE | Summary: Interaction with UniProtKB:Q16543 (CDC37) detected in a quantitative chaperone/cochaperone-client interaction network (LUMIER/AP-MS). Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. HSP90/CDC37 binding reflects FGFR3 being a kinase client of the chaperone machinery (folding/maturation), not a signalling function of FGFR3. Supporting Evidence: PMID:25036637 We uncover hundreds of chaperone clients |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:A0A0A0MR05 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:A0AVK6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:A1KXE4-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:A5D8V7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:A8K0U2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:B7Z3E8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:F1D8P7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O00257-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O00472 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O00755 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O14519 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O14544 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O14641 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O15212 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O15273 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O15534 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O43248 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O43482 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O43504 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O43741 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O43768-8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O43829 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60237-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60260-5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60479 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60636 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60759 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60783 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60830 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60902-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O60927 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O75886 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O94868-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:O95674 (CDS2) detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P01106 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P02458-1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P05412 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P06454-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P08727 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P09629 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P0DP58-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P10809 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P11441 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P14060 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P14598 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P14618 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P15407 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P15408 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P15976-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P17275 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P19388 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P19544-6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P20807-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P21964-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P22415 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P22692 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P23769-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P23771 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P24941 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P27338 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P33993-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P36406 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P38936 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P41134 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P41271-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P47804-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P49459 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P50616 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P52655 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P53677-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P54274-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P54687-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P55008 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P55318 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P57682 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P62244 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P62333 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P62701 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:P62899 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q00013 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q00994 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q02086-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q03060-25 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q04206 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q06323 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q06547-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q06547-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q07869 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q12824 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q13352 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q13404 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q13435 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q13573 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q13586 (STIM1) detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q13956 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q14117 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q14525 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q14847-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q14995 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q15311 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q15382 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q15486 (GUSBP1) detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q15759 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q15814 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q15910-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q16520 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q16621 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q1L5Z9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q2M2Z5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q3KNS6-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q3LI72 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q3SX64 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q3SYF9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q494V2-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q495M9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q495U3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q496A3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q49A26-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q4KMX9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q4VB01 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q53FD0-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q53GQ0 (HSD17B12) detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q53NU3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q53T59 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5BJF6-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5H9J7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5JXC2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5M9N0-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5PSV4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5SXH7-1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5T0J7-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5T1C6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5T447-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5VU43-8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q5W111-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q658K8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q66K80 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q66PJ3-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q68G74 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6GQQ9-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6H8Q1-8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6IAA8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6IN84-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6N021 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6NXG1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6P597 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6P5X5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6PF05 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6PHZ7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6UXG2-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6UY14-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6XD76 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6ZMI0-5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6ZN54-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6ZP82-1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q6ZR37 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q71RG4-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7L8T7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7Z5G4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7Z637 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7Z698 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7Z6I5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7Z7F0-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q7Z7J5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86SQ7-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86U28 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86UA1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86UY5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86V28 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86VI3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86W54-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86WT6-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86WV2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86WV5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q86XR8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IUC2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IUR5-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IV36 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IVL6-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IXN7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IY31-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8IZU1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N0U2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N0U6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N302-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N3R9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N4C7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N5V2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8N5Z5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NA54 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NB25 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NC06-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NC67-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NDH6-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NDP9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8NEZ2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TAC0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TB03 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TBE0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TBY0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TBZ3-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TC84 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8TCY5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8WTV1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8WUD1-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8WUU4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8WUX9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q8WVD3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q92782-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q92783-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96A09 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96B77 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96BR5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96CS2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96EW2-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96EY1-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96EZ8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96FT7-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96GL9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96GN5-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96H12 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96HB5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96I34 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96JB6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96JL9-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96LL4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96LR2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96MF7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q96T60 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q99075 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q99469 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q99598 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q99743 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q99996-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BPU6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BR81 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BT25 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BUL5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BVC3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BVG8-5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BWF3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BXU0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BY12-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BZ95-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9BZW5-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9C004 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9C0F3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9GZM8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9GZQ8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H0X6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H147 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H270 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H2A9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H2C1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H2G9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H3R5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H496 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H7T9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H8H3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9H8K7 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9HA47-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9HAF1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9HD47-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NP64 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NPC6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NQ31 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NR21-5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NS23-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NS73-5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NSD5-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NSI6-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NTN9-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NWB1-5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NWQ4-1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NX94 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NXL2-1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NXX0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9NZH6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9P0T4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9P1Q0-4 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9P2K3-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UBX5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UGJ1-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UH77 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UHI5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UII2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UJU6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UKV8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9ULD4-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9ULK2-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UNP9 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UNT1-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UPQ4-2 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UPR0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9UQB8-6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y2M5 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y2Y0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y3D0 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y3I1 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y3Q8 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y4F5-3 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Interaction with UniProtKB:Q9Y6W6 detected in a systematic yeast two-hybrid screen of neurodegenerative-disease-related proteins. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32814053 generated by systematic yeast two-hybrid interaction screening of |
| GO:0005515 protein binding | IPI PMID:32822567 A Human IgSF Cell-Surface Interactome Reveals a Complex Netw... | REMOVE | Summary: Interaction with UniProtKB:Q9NP60 (IL1RAPL2) detected in a high-throughput ELISA-based IgSF cell-surface interactome screen. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:32822567 We executed an interactome screen of 564 human cell-surface and secreted proteins |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Interaction with UniProtKB:Q16543 (CDC37) detected in the BioPlex 3.0 / HCT116 affinity-purification mass spectrometry network. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. HSP90/CDC37 binding reflects FGFR3 being a kinase client of the chaperone machinery (folding/maturation), not a signalling function of FGFR3. Supporting Evidence: PMID:33961781 Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Interaction with UniProtKB:O95674 (CDS2) detected in an AP-MS/BioID interactome atlas of receptor tyrosine kinases. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:35384245 proximity-dependent biotin identification (BioID) to identify transient and proximal interactions |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Interaction with UniProtKB:P08238 (HSP90AB1) detected in an AP-MS/BioID interactome atlas of receptor tyrosine kinases. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. HSP90/CDC37 binding reflects FGFR3 being a kinase client of the chaperone machinery (folding/maturation), not a signalling function of FGFR3. Supporting Evidence: PMID:35384245 proximity-dependent biotin identification (BioID) to identify transient and proximal interactions |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Interaction with UniProtKB:Q13586 (STIM1) detected in an AP-MS/BioID interactome atlas of receptor tyrosine kinases. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:35384245 proximity-dependent biotin identification (BioID) to identify transient and proximal interactions |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Interaction with UniProtKB:Q16543 (CDC37) detected in an AP-MS/BioID interactome atlas of receptor tyrosine kinases. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. HSP90/CDC37 binding reflects FGFR3 being a kinase client of the chaperone machinery (folding/maturation), not a signalling function of FGFR3. Supporting Evidence: PMID:35384245 proximity-dependent biotin identification (BioID) to identify transient and proximal interactions |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Interaction with UniProtKB:Q53GQ0 (HSD17B12) detected in an AP-MS/BioID interactome atlas of receptor tyrosine kinases. Reason: Generic protein binding is uninformative about FGFR3 function; removal does not imply the interaction is false. The partner is not a known FGFR3 signalling effector and the high-throughput data do not support a more specific molecular function. Supporting Evidence: PMID:35384245 proximity-dependent biotin identification (BioID) to identify transient and proximal interactions |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: InterPro kinase domain mapping. Reason: ATP binding is intrinsic to the catalytically active kinase domain. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0005576 extracellular region | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: UniProt subcellular location mapping (secreted isoform 3, FGFR3deltaTM). Reason: Applies only to the secreted FGFR3deltaTM splice isoform, which may act as a ligand trap; the canonical receptor is membrane-bound. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt [Isoform 3]: Secreted. |
| GO:0005783 endoplasmic reticulum | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: Immunofluorescence (HPA-type) localization. Reason: FGFR3 transits the ER during biosynthesis and N-glycosylation; severe pathogenic mutants accumulate there. The ER is not the site of its signalling function. ORGANELLES ER check (2026-11-05): this is direct immunofluorescence evidence (GO_REF:0000052, antibody staining of the endogenous protein), which cannot resolve membrane versus lumen, so under rule 2 the row stays KEEP_AS_NON_CORE. It agrees with curated UniProt PTM text (ECO:0000269, four papers) that wild-type FGFR3 is N-glycosylated in the ER before Golgi maturation, a real biosynthetic pool of the gene itself (the ABCA4 and BACE2 case in ER batch 1). The mutant accumulation in PMID:17561467 is quality-control retention and is supportive only. No NEW ER membrane row is added: a single-pass type I receptor passing through the ER would only be claimed to reside there. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt N-glycosylated in the endoplasmic reticulum. The N-glycan chains PMID:17561467 Immunofluorescence analysis showed accumulations of TDII-FGFR3, SADDAN-FGFR3, and a portion of TDI-FGFR3 in the endoplasmic reticulum (ER). |
| GO:0005783 endoplasmic reticulum | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: UniProt subcellular location mapping. Reason: FGFR3 transits the ER during biosynthesis and N-glycosylation; severe pathogenic mutants accumulate there. The ER is not the site of its signalling function. ORGANELLES ER check (2026-11-05): SL-0095 comes from UniProt's isoform 1 (IIIc, the displayed isoform) location line, which carries no evidence tag; the ER claim is upheld by the HPA immunofluorescence row and the curated PTM text on ER N-glycosylation, so the row matches the IDA row as KEEP_AS_NON_CORE. Isoform 1 is the canonical sequence the GOA row is made on, and the IIIb isoform is also a type I membrane receptor that must pass through the ER, so no isoform source defect is recorded. No sub-compartment row, as for the IDA row. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt N-glycosylated in the endoplasmic reticulum. The N-glycan chains PMID:17561467 Immunofluorescence analysis showed accumulations of TDII-FGFR3, SADDAN-FGFR3, and a portion of TDI-FGFR3 in the endoplasmic reticulum (ER). |
| GO:0005794 Golgi apparatus | IDA PMID:18061161 The cell surface receptor FGFRL1 forms constitutive dimers t... | KEEP AS NON CORE | Summary: Golgi detection of FGFR3 (PMID:18061161; abstract-only in cache, FGFR3 presumably assayed alongside FGFRL1 in the full text). Reason: Plausible: FGFR3 N-glycans mature to an Endo H-resistant form in the Golgi on the way to the surface. Transit compartment, not site of function. Deferring to the curator who read the full text. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt undergo further maturation to an Endo H-resistant form in the Golgi |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference (PAINT). Reason: The plasma membrane is where FGFR3 binds ligand and signals. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | IDA PMID:18061161 The cell surface receptor FGFRL1 forms constitutive dimers t... | ACCEPT | Summary: Cell-surface detection of FGFR3. Reason: The plasma membrane is where FGFR3 binds ligand and signals. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: Cell-surface detection of FGFR3. Reason: The plasma membrane is where FGFR3 binds ligand and signals. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: UniProt subcellular location mapping. Reason: The plasma membrane is where FGFR3 binds ligand and signals. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS PMID:10918587 Transformation and Stat activation by derivatives of FGFR1, ... | ACCEPT | Summary: Author statement. Reason: The plasma membrane is where FGFR3 binds ligand and signals. Supporting Evidence: PMID:10918587 when targeted to the plasma membrane by a myristylation signal, can transform NIH3T3 cells |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-109699) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190261 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-190261) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190263 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-190263) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190385 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-190385) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-190388 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-190388) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2012073 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2012073) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2012074 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2012074) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2012082 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2012082) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2012084 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2012084) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033476 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2033476) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2033485 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2033485) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2038386 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2038386) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2038387 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2038387) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2077420 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2077420) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2316434) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-2400009) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654148 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654148) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654222 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654222) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654224 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654224) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654408 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654408) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654409 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654409) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654413 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654413) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654416 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654416) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654565 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654565) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654623 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654623) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654625 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654625) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654628 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654628) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654631 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654631) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654633 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654633) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654634 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654634) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654637 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654637) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654640 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654640) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654641 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654641) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654643 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654643) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654646 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654646) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654647 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654647) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654679 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654679) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654705 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654705) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654709 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654709) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654730 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5654730) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655243 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655243) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655244 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655244) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655247 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655247) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655262 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655262) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655270 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655270) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655277 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655277) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655285 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655285) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655289 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655289) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655295 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655295) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655315 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5655315) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-5672965) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8853309 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-8853309) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8853317 | ACCEPT | Summary: Reactome reaction (Reactome:R-HSA-8853317) placing FGFR3 in the plasma membrane. Reason: FGFR3 (isoforms 1, 2, 4) is a single-pass type I plasma membrane receptor; correct. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0005925 focal adhesion | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | UNDECIDED | Summary: Colocalization with focal adhesions asserted from a review (PMID:15748888). Reason: The cached review is abstract-only and its abstract does not mention focal adhesions; no primary FGFR3 focal-adhesion data were found in the materials available. Cannot verify, so left undecided rather than removed. |
| GO:0007259 cell surface receptor signaling pathway via JAK-STAT | IMP PMID:11294897 Identification of tyrosine residues in constitutively activa... | MODIFY | Summary: Activated FGFR3 induces STAT1/STAT3 tyrosine phosphorylation. Reason: The cited work shows STAT activation by the receptor but not a JAK-dependent route; in chondrocytes STAT1 activation is PLCgamma-dependent. The less committed parent, cell surface receptor signaling pathway via STAT (GO:0097696), is appropriate. Proposed replacements: cell surface receptor signaling pathway via STAT Supporting Evidence: PMID:11294897 Addition of a single tyrosine residue, Y724, restored its ability to stimulate cellular transformation, phosphatidylinositol 3-kinase activation, and phosphorylation of Shp2, MAPK, Stat1, and Stat3. PMID:17561467 Both PLCgamma and STAT1 were activated by FGFR3 signaling, but a dominant-negative form of PLCgamma (DN-PLCgamma) remarkably reduced STAT1 phosphorylation. |
| GO:0008284 positive regulation of cell population proliferation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Phylogenetic inference (PAINT). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. PMID:15748888 STAT1 phosphorylation seems to be involved in inhibition of chondrocyte proliferation while activation of the ERK pathway inhibits chondrocyte differentiation and B-cell proliferation |
| GO:0008284 positive regulation of cell population proliferation | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Automated annotation. Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. PMID:15748888 STAT1 phosphorylation seems to be involved in inhibition of chondrocyte proliferation while activation of the ERK pathway inhibits chondrocyte differentiation and B-cell proliferation |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: FGF-ligand-dependent mitogenesis of BaF3 cells expressing FGFR3 (ligand given in WITH). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: FGF-ligand-dependent mitogenesis of BaF3 cells expressing FGFR3 (ligand given in WITH). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: FGF-ligand-dependent mitogenesis of BaF3 cells expressing FGFR3 (ligand given in WITH). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: FGF-ligand-dependent mitogenesis of BaF3 cells expressing FGFR3 (ligand given in WITH). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: FGF-ligand-dependent mitogenesis of BaF3 cells expressing FGFR3 (ligand given in WITH). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008284 positive regulation of cell population proliferation | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: FGF-ligand-dependent mitogenesis of BaF3 cells expressing FGFR3 (ligand given in WITH). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:11294897 Identification of tyrosine residues in constitutively activa... | KEEP AS NON CORE | Summary: Mitogenic assays with FGFR3 (engineered BaF3 cells, or activated FGFR3 tyrosine mutants). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:11294897 Addition of a single tyrosine residue, Y724, restored its ability to stimulate cellular transformation, phosphatidylinositol 3-kinase activation, and phosphorylation of Shp2, MAPK, Stat1, and Stat3. |
| GO:0008284 positive regulation of cell population proliferation | IMP PMID:8663044 Receptor specificity of the fibroblast growth factor family. | KEEP AS NON CORE | Summary: Mitogenic assays with FGFR3 (engineered BaF3 cells, or activated FGFR3 tyrosine mutants). Reason: FGFR3 signalling is mitogenic in engineered BaF3/NIH3T3 cells and in myeloma/bladder cancer, but its principal physiological effect in growth-plate chondrocytes is anti-proliferative. The direction is cell-context dependent, so positive regulation of proliferation is kept but not treated as core. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference (PAINT). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF-induced mitogenic signalling in FGFR3-expressing BaF3 cells. Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IEA GO_REF:0000002 | ACCEPT | Summary: InterPro mapping. Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Tyrosine-protein kinase that acts as a cell-surface receptor |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligand-dependent signalling through FGFR3 in engineered BaF3 cells (ligand given in WITH). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligand-dependent signalling through FGFR3 in engineered BaF3 cells (ligand given in WITH). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligand-dependent signalling through FGFR3 in engineered BaF3 cells (ligand given in WITH). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligand-dependent signalling through FGFR3 in engineered BaF3 cells (ligand given in WITH). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligand-dependent signalling through FGFR3 in engineered BaF3 cells (ligand given in WITH). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligand-dependent signalling through FGFR3 in engineered BaF3 cells (ligand given in WITH). Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:8663044 To determine potentially relevant ligand-receptor pairs we have engineered mitogenically responsive cell lines expressing the major splice variants of all the known FGF receptors. |
| GO:0008543 fibroblast growth factor receptor signaling pathway | TAS PMID:10918587 Transformation and Stat activation by derivatives of FGFR1, ... | ACCEPT | Summary: Author statement from activated FGFR derivatives. Reason: FGFR3 is the receptor that initiates the FGF receptor signalling pathway; this is its core process. Supporting Evidence: PMID:10918587 Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated |
| GO:0010518 positive regulation of phospholipase activity | IMP PMID:17561467 Sustained phosphorylation of mutated FGFR3 is a crucial feat... | KEEP AS NON CORE | Summary: FGFR3 signalling activates PLCgamma in ATDC5 chondrogenic cells. Reason: FGFR3 phosphorylates and activates PLCG1; supported, but a downstream effector activation rather than a core function. Supporting Evidence: PMID:17561467 Both PLCgamma and STAT1 were activated by FGFR3 signaling, but a dominant-negative form of PLCgamma (DN-PLCgamma) remarkably reduced STAT1 phosphorylation. file:human/FGFR3/FGFR3-uniprot.txt development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. |
| GO:0016020 membrane | IEA GO_REF:0000002 | ACCEPT | Summary: InterPro mapping. Reason: Correct but general; plasma membrane is the specific location. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Cell membrane; Single-pass type I |
| GO:0017134 fibroblast growth factor binding | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference (PAINT) for the FGFR clade. Reason: FGFR3 binds multiple FGFs via its D2-D3 region; FGF binding is the ligand-recognition part of its core receptor function. Supporting Evidence: PMID:14732692 Here, we report the crystal structure of the three-Ig form of FGFR3c in complex with FGF1 |
| GO:0017134 fibroblast growth factor binding | IDA PMID:8663044 Receptor specificity of the fibroblast growth factor family. | ACCEPT | Summary: FGF ligands activate BaF3 cells expressing FGFR3 splice variants. Reason: FGFR3 binds multiple FGFs via its D2-D3 region; FGF binding is the ligand-recognition part of its core receptor function. Supporting Evidence: PMID:8663044 These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants. |
| GO:0017134 fibroblast growth factor binding | IEA GO_REF:0000117 | ACCEPT | Summary: ARBA machine-learning annotation. Reason: FGFR3 binds multiple FGFs via its D2-D3 region; FGF binding is the ligand-recognition part of its core receptor function. Supporting Evidence: PMID:14732692 Here, we report the crystal structure of the three-Ig form of FGFR3c in complex with FGF1 |
| GO:0030133 transport vesicle | IDA PMID:18061161 The cell surface receptor FGFRL1 forms constitutive dimers t... | KEEP AS NON CORE | Summary: Transport vesicle detection of FGFR3 (PMID:18061161; abstract-only in cache). Reason: Plausible trafficking compartment (biosynthetic delivery and post-activation internalization). Cannot verify the FGFR3-specific data, but no reason to reject; not a site of core function. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt intracellular vesicles after internalization of the autophosphorylated |
| GO:0030282 bone mineralization | ISS PMID:20582225 Generation of Fgfr3 conditional knockout mice. | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (ISS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:20582225 These mice showed increased length of long bone and decreased bone mineral density file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0031410 cytoplasmic vesicle | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: UniProt subcellular location mapping. Reason: Activated FGFR3 is internalized into vesicles and degraded; correct but reflects receptor down-regulation. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt intracellular vesicles after internalization of the autophosphorylated |
| GO:0035988 chondrocyte proliferation | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | MODIFY | Summary: Review statement on FGFR3 control of chondrocyte proliferation. Reason: FGFR3 restrains rather than drives growth-plate chondrocyte proliferation (knockout expands proliferating zone; STAT1 arm inhibits proliferation). Negative regulation of chondrocyte proliferation (GO:1902731) states the direction. Proposed replacements: negative regulation of chondrocyte proliferation Supporting Evidence: PMID:15748888 STAT1 phosphorylation seems to be involved in inhibition of chondrocyte proliferation while activation of the ERK pathway inhibits chondrocyte differentiation and B-cell proliferation PMID:8601314 This growth is accompanied by expansion of proliferating and hypertrophic chondrocytes within the cartilaginous growth plate. |
| GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein | IMP PMID:17561467 Sustained phosphorylation of mutated FGFR3 is a crucial feat... | KEEP AS NON CORE | Summary: FGFR3 signalling activates STAT1 phosphorylation (PLCgamma-dependent) in ATDC5 chondrogenic cells. Reason: Supported, and relevant to the STAT1-mediated growth arrest of chondrocytes, but a downstream regulatory consequence rather than the core activity. Supporting Evidence: PMID:17561467 Both PLCgamma and STAT1 were activated by FGFR3 signaling, but a dominant-negative form of PLCgamma (DN-PLCgamma) remarkably reduced STAT1 phosphorylation. |
| GO:0042802 identical protein binding | IPI PMID:14732692 Insights into the molecular basis for fibroblast growth fact... | ACCEPT | Summary: FGFR3 self-association supported by the FGF1-FGFR3c ectodomain crystal structure. Reason: Ligand-induced FGFR3 homodimerization, mediated by ectodomain, TM helix and kinase-kinase contacts, is mechanistically central: trans-autophosphorylation within the dimer activates the receptor. Identical protein binding is an appropriate, informative term here. Supporting Evidence: PMID:14732692 Here, we report the crystal structure of the three-Ig form of FGFR3c in complex with FGF1 file:human/FGFR3/FGFR3-uniprot.txt Ligand binding leads to dimerization and activation by |
| GO:0042802 identical protein binding | IPI PMID:23972473 Structural mimicry of a-loop tyrosine phosphorylation by a p... | ACCEPT | Summary: FGFR3 self-association supported by the crystal structure of the K650E FGFR3 kinase caught in trans-phosphorylation between two kinase molecules. Reason: Ligand-induced FGFR3 homodimerization, mediated by ectodomain, TM helix and kinase-kinase contacts, is mechanistically central: trans-autophosphorylation within the dimer activates the receptor. Identical protein binding is an appropriate, informative term here. Supporting Evidence: PMID:23972473 In the crystal, the mutant FGFR3 kinases are caught in the act of trans-phosphorylation on a kinase insert autophosphorylation site file:human/FGFR3/FGFR3-uniprot.txt Ligand binding leads to dimerization and activation by |
| GO:0042802 identical protein binding | IPI PMID:24120763 Structure of FGFR3 transmembrane domain dimer: implications ... | ACCEPT | Summary: FGFR3 self-association supported by the NMR structure of the FGFR3 transmembrane-domain homodimer. Reason: Ligand-induced FGFR3 homodimerization, mediated by ectodomain, TM helix and kinase-kinase contacts, is mechanistically central: trans-autophosphorylation within the dimer activates the receptor. Identical protein binding is an appropriate, informative term here. Supporting Evidence: PMID:24120763 In the solved NMR structure, the two transmembrane helices pack into a symmetric left-handed dimer file:human/FGFR3/FGFR3-uniprot.txt Ligand binding leads to dimerization and activation by |
| GO:0043235 signaling receptor complex | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference (PAINT). Reason: FGFR3 functions within a ligand-receptor-heparan sulfate (and for endocrine FGFs, Klotho) signalling complex; appropriate. Supporting Evidence: file:human/FGFR3/FGFR3-uniprot.txt Ligand binding leads to dimerization and activation by |
| GO:0043410 positive regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic inference (PAINT). Reason: Activation of the RAS-MAPK (ERK1/2) cascade via FRS2/GRB2/SOS is a principal FGFR3 output. Supporting Evidence: PMID:10918587 Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated |
| GO:0043410 positive regulation of MAPK cascade | IEA GO_REF:0000117 | ACCEPT | Summary: ARBA annotation. Reason: Activation of the RAS-MAPK (ERK1/2) cascade via FRS2/GRB2/SOS is a principal FGFR3 output. Supporting Evidence: PMID:10918587 Phosphorylation of Shp2, PLC-gamma, and MAPK was also stimulated |
| GO:0043410 positive regulation of MAPK cascade | IMP PMID:11294897 Identification of tyrosine residues in constitutively activa... | ACCEPT | Summary: Y724 add-back mutant restores MAPK phosphorylation by activated FGFR3. Reason: Activation of the RAS-MAPK (ERK1/2) cascade via FRS2/GRB2/SOS is a principal FGFR3 output. Supporting Evidence: PMID:11294897 Addition of a single tyrosine residue, Y724, restored its ability to stimulate cellular transformation, phosphatidylinositol 3-kinase activation, and phosphorylation of Shp2, MAPK, Stat1, and Stat3. |
| GO:0048640 negative regulation of developmental growth | ISS PMID:20582225 Generation of Fgfr3 conditional knockout mice. | ACCEPT | Summary: Transferred from mouse Fgfr3 knockout (long bones). Reason: Loss of Fgfr3 causes skeletal overgrowth and human gain-of-function alleles cause dwarfism: FGFR3 signalling restrains growth. This captures the paralog-specific physiological role. Supporting Evidence: PMID:20582225 These mice showed increased length of long bone and decreased bone mineral density PMID:8601314 FGFR-3 appears to regulate endochondral ossification by an essentially negative mechanism, limiting rather than promoting osteogenesis. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0051216 cartilage development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (IEA). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:15748888 Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | IMP PMID:11294897 Identification of tyrosine residues in constitutively activa... | KEEP AS NON CORE | Summary: FGFR3 activation (Y724/Y760-dependent) stimulates PI3K activity. Reason: PI3K/AKT activation is a genuine but secondary FGFR3 output (via GAB1/PIK3R1). Supporting Evidence: PMID:11294897 Addition of a single tyrosine residue, Y724, restored its ability to stimulate cellular transformation, phosphatidylinositol 3-kinase activation, and phosphorylation of Shp2, MAPK, Stat1, and Stat3. |
| GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | KEEP AS NON CORE | Summary: FGFR3 activation (Y724/Y760-dependent) stimulates PI3K activity. Reason: PI3K/AKT activation is a genuine but secondary FGFR3 output (via GAB1/PIK3R1). Supporting Evidence: PMID:10918587 Finally, we demonstrate that FGFR1, FGFR3, and FGFR4 derivatives can stimulate PI-3 kinase activity. |
| GO:0060349 bone morphogenesis | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (IEA). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:15748888 Fgfr3 knockout mice display longer bones and, accordingly, most germline-activating mutations in man are associated with dwarfism. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0060349 bone morphogenesis | ISS PMID:20582225 Generation of Fgfr3 conditional knockout mice. | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (ISS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:20582225 These mice showed increased length of long bone and decreased bone mineral density file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0060349 bone morphogenesis | TAS PMID:15748888 Cell responses to FGFR3 signalling: growth, differentiation ... | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (TAS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:15748888 FGFR3 is a receptor tyrosine kinase (RTK) of the FGF receptor family, known to have a negative regulatory effect on long bone growth. file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:0070374 positive regulation of ERK1 and ERK2 cascade | IMP PMID:11294897 Identification of tyrosine residues in constitutively activa... | ACCEPT | Summary: Y724-dependent ERK1/2 (p42/p44 MAPK) phosphorylation by activated FGFR3. Reason: ERK1/2 activation is a principal FGFR3 output; in chondrocytes ERK signalling contributes to inhibition of differentiation. Supporting Evidence: PMID:11294897 Addition of a single tyrosine residue, Y724, restored its ability to stimulate cellular transformation, phosphatidylinositol 3-kinase activation, and phosphorylation of Shp2, MAPK, Stat1, and Stat3. PMID:15748888 STAT1 phosphorylation seems to be involved in inhibition of chondrocyte proliferation while activation of the ERK pathway inhibits chondrocyte differentiation and B-cell proliferation |
| GO:0070977 bone maturation | ISS PMID:20582225 Generation of Fgfr3 conditional knockout mice. | KEEP AS NON CORE | Summary: Skeletal developmental process annotation (ISS). Reason: FGFR3 is a major regulator of endochondral skeletal growth (negative regulator of bone growth; also affects osteoblast mineralization), but these broad developmental terms describe a tissue-level outcome of its receptor signalling rather than its core function. The growth restraint is better captured by negative regulation of chondrocyte proliferation/differentiation and negative regulation of developmental growth. Supporting Evidence: PMID:20582225 These mice showed increased length of long bone and decreased bone mineral density file:human/FGFR3/FGFR3-deep-research-falcon.md Conversely, loss of FGFR3 function produces skeletal overgrowth, confirming its role as a brake on bone growth |
| GO:1902178 fibroblast growth factor receptor apoptotic signaling pathway | IMP PMID:17561467 Sustained phosphorylation of mutated FGFR3 is a crucial feat... | ACCEPT | Summary: Constitutively active FGFR3 induces caspase-dependent apoptosis of ATDC5 chondrogenic cells via PLCgamma-STAT1. Reason: FGFR3-induced chondrocyte apoptosis via PLCgamma-STAT1 is a distinctive, experimentally supported FGFR3 signalling output. Supporting Evidence: PMID:17561467 we conclude that a PLCgamma-STAT1 pathway mediates apoptotic signaling by FGFR3. |
| GO:0008201 heparin binding | IDA PMID:14732692 Insights into the molecular basis for fibroblast growth fact... | NEW | Summary: SPR shows FGFR3c ectodomain binds heparin, with the D1/linker autoinhibiting heparin binding. Reason: Direct heparin/heparan sulfate binding by the FGFR D2 domain is a required co-receptor interaction for FGF-FGFR signalling complex assembly and is measured directly for FGFR3c. Supporting Evidence: PMID:14732692 the three-Ig form of FGFR3c exhibits lower affinity for both FGF1 and heparin |
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Download this section (compressed HTML)Q: Is STAT1 activation by FGFR3 in chondrocytes JAK-independent (direct receptor or PLCgamma-dependent), and should GO:0007259 JAK-STAT annotations on FGFRs be replaced by GO:0097696 generally?
Q: Which FGFR3 outputs are paralog-specific (growth-plate restraint, inner ear) versus shared with FGFR1/FGFR2, and should the FGFR module encode FGFR3 growth restraint as a distinct regulatory step?
Q: Does the FGFRL1 paper (PMID:18061161) contain primary FGFR3 localization data supporting the Golgi and transport vesicle IDA annotations?
Q: Is there primary evidence for FGFR3 colocalization with focal adhesions, or should GO:0005925 be retired?
Experiment: Chondrocyte-specific knock-in of kinase-dead versus STAT1-binding-deficient FGFR3 to separate growth restraint arms (STAT1 vs ERK) in vivo.
Experiment: Quantitative FGF ligand/Klotho specificity profiling of FGFR3b versus FGFR3c at the cell surface using purified components and SPR.
Experiment: Endogenous-level proximity labelling (BioID/TurboID) of FGFR3 in chondrocytes to identify context-specific effectors responsible for anti-proliferative signalling.
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