FRS2 (fibroblast growth factor receptor substrate 2, also FRS2alpha or SNT-1) is a membrane-anchored docking protein that couples receptor tyrosine kinases, principally the FGF receptors, to intracellular signalling. N-terminal myristoylation anchors it to the cytoplasmic face of the plasma membrane, and its IRS-type phosphotyrosine-binding (PTB) domain binds constitutively to a non-phosphorylated juxtamembrane motif of FGFRs and, in an activation-dependent manner, to phosphorylated NPXpY sites on Trk neurotrophin receptors (where it competes with SHC) and other RTKs including ALK and RET. On receptor activation its long disordered C-terminal tail is phosphorylated on multiple tyrosines that serve as SH2 docking sites for GRB2 and the phosphatase SHP2/PTPN11, assembling GRB2-SOS complexes that activate Ras-MAPK signalling and GRB2-GAB1 complexes that recruit PI3K and activate AKT. ERK-mediated threonine phosphorylation and CBL-dependent ubiquitination of FRS2 provide negative feedback. FRS2 is broadly expressed and is required for many FGF-dependent developmental processes; its paralog FRS3 shares the same architecture.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: FRS2 is a myristoyl-anchored PTB-domain docking protein that binds the FGFR juxtamembrane region and, once tyrosine-phosphorylated by the receptor, recruits GRB2-SOS, SHP2 and (via GRB2-GAB1) PI3K. This is the canonical transmembrane RTK adaptor activity (IBA). Reason: The term definition (a binding activity that brings together a transmembrane RTK and other molecules so they function coordinately) is exactly what FRS2 does for FGFRs and, in an activation-dependent way, for TrkA/Trk receptors, ALK and EGFR. Direct PTB-FGFR1 binding and downstream effector recruitment are experimentally established; the IBA placement at the FRS2/FRS3 node is phylogenetically sound and the ortholog IEA transfer is from mouse Frs2 IDA. Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:9632781 These experiments demonstrate that FRS2 recruits Grb2 molecules both directly and indirectly via complex formation with Shp2 PMID:11353842 we demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase file:human/FRS2/FRS2-deep-research-falcon.md FRS2 functions as a lipid-anchored signaling scaffold that couples activated receptor tyrosine kinases—principally FGFRs—to intracellular signaling cascades |
| GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: FRS2 is a myristoyl-anchored PTB-domain docking protein that binds the FGFR juxtamembrane region and, once tyrosine-phosphorylated by the receptor, recruits GRB2-SOS, SHP2 and (via GRB2-GAB1) PI3K. This is the canonical transmembrane RTK adaptor activity (IEA). Reason: The term definition (a binding activity that brings together a transmembrane RTK and other molecules so they function coordinately) is exactly what FRS2 does for FGFRs and, in an activation-dependent way, for TrkA/Trk receptors, ALK and EGFR. Direct PTB-FGFR1 binding and downstream effector recruitment are experimentally established; the IBA placement at the FRS2/FRS3 node is phylogenetically sound and the ortholog IEA transfer is from mouse Frs2 IDA. Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:9632781 These experiments demonstrate that FRS2 recruits Grb2 molecules both directly and indirectly via complex formation with Shp2 PMID:11353842 we demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase file:human/FRS2/FRS2-deep-research-falcon.md FRS2 functions as a lipid-anchored signaling scaffold that couples activated receptor tyrosine kinases—principally FGFRs—to intracellular signaling cascades |
| GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | ACCEPT | Summary: FRS2 is a myristoyl-anchored PTB-domain docking protein that binds the FGFR juxtamembrane region and, once tyrosine-phosphorylated by the receptor, recruits GRB2-SOS, SHP2 and (via GRB2-GAB1) PI3K. This is the canonical transmembrane RTK adaptor activity (TAS). Reason: The term definition (a binding activity that brings together a transmembrane RTK and other molecules so they function coordinately) is exactly what FRS2 does for FGFRs and, in an activation-dependent way, for TrkA/Trk receptors, ALK and EGFR. Direct PTB-FGFR1 binding and downstream effector recruitment are experimentally established; the IBA placement at the FRS2/FRS3 node is phylogenetically sound and the ortholog IEA transfer is from mouse Frs2 IDA. Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:9632781 These experiments demonstrate that FRS2 recruits Grb2 molecules both directly and indirectly via complex formation with Shp2 PMID:11353842 we demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase file:human/FRS2/FRS2-deep-research-falcon.md FRS2 functions as a lipid-anchored signaling scaffold that couples activated receptor tyrosine kinases—principally FGFRs—to intracellular signaling cascades |
| GO:0005104 fibroblast growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: Direct binding of the FRS2 PTB domain to a conserved non-phosphotyrosine juxtamembrane motif of FGFR1 is well established by yeast two-hybrid, in vitro binding, mutagenesis and NMR (IBA). Reason: FGFR binding is the receptor-recognition half of FRS2's adaptor activity and is informative (receptor-specific, constitutive, PTB-mediated). Retained as a core-supporting MF alongside GO:0005068. Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation PMID:11090629 The SNT-1 phosphotyrosine binding (PTB) domain recognizes activated TRKs at a canonical NPXpY motif and, atypically, binds to nonphosphorylated FGFRs in a region lacking tyrosine or asparagine |
| GO:0005104 fibroblast growth factor receptor binding | IEA GO_REF:0000117 | ACCEPT | Summary: Direct binding of the FRS2 PTB domain to a conserved non-phosphotyrosine juxtamembrane motif of FGFR1 is well established by yeast two-hybrid, in vitro binding, mutagenesis and NMR (IEA). Reason: FGFR binding is the receptor-recognition half of FRS2's adaptor activity and is informative (receptor-specific, constitutive, PTB-mediated). Retained as a core-supporting MF alongside GO:0005068. Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation PMID:11090629 The SNT-1 phosphotyrosine binding (PTB) domain recognizes activated TRKs at a canonical NPXpY motif and, atypically, binds to nonphosphorylated FGFRs in a region lacking tyrosine or asparagine |
| GO:0005104 fibroblast growth factor receptor binding | IPI PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | ACCEPT | Summary: Direct binding of the FRS2 PTB domain to a conserved non-phosphotyrosine juxtamembrane motif of FGFR1 is well established by yeast two-hybrid, in vitro binding, mutagenesis and NMR (IPI). Reason: FGFR binding is the receptor-recognition half of FRS2's adaptor activity and is informative (receptor-specific, constitutive, PTB-mediated). Retained as a core-supporting MF alongside GO:0005068. Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation PMID:11090629 The SNT-1 phosphotyrosine binding (PTB) domain recognizes activated TRKs at a canonical NPXpY motif and, atypically, binds to nonphosphorylated FGFRs in a region lacking tyrosine or asparagine |
| GO:0005168 neurotrophin TRKA receptor binding | IPI PMID:15488758 TrkA alternative splicing: a regulated tumor-promoting switc... | ACCEPT | Summary: FRS2 binds ligand-activated TrkA through its PTB domain at the phosphorylated NPXpY (Y490/Y496) site shared with SHC. The cited Tacconelli et al. 2004 abstract (TrkAIII splice variant) does not mention FRS2, so the IPI presumably derives from full-text data; the interaction itself is independently well supported. Reason: Deferring to the curator for the IPI (cached paper is abstract-only). TrkA binding is independently established by Meakin et al. 1999, Ong et al. 2000 and the Dhalluin et al. 2000 NMR study, and is the receptor-recognition step of FRS2's adaptor role in neurotrophin signalling. Supporting Evidence: PMID:10092678 we demonstrate that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation PMID:11090629 The SNT-1 phosphotyrosine binding (PTB) domain recognizes activated TRKs at a canonical NPXpY motif and, atypically, binds to nonphosphorylated FGFRs in a region lacking tyrosine or asparagine Reactome:R-HSA-170964 FRS2 binds to TRKA through the same motif (NPXY) around the TRKA phospho-tyrosine residue Y496 to which SHC proteins bind. |
| GO:0005515 protein binding | IPI PMID:21765395 Nedd4-1 binds and ubiquitylates activated FGFR1 to control i... | MODIFY | Summary: IPI with FGFR1 (PMID:21765395). Generic 'protein binding' is uninformative; the interaction is the well-characterized direct PTB-domain binding of FRS2 to the FGFR1 juxtamembrane region. Persaud et al. 2011 studied Nedd4-1 control of FGFR1 endocytosis with FRS2alpha as a downstream readout. Reason: Per curation policy, replace generic protein binding with the informative receptor-binding term already supported for FRS2 (GO:0005104 fibroblast growth factor receptor binding). Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation |
| GO:0005515 protein binding | IPI PMID:29997244 LuTHy: a double-readout bioluminescence-based two-hybrid tec... | MODIFY | Summary: IPI with PTPN11/SHP2 from the LuTHy bioluminescence two-hybrid method paper (high-throughput interaction mapping). Consistent with the well-established FRS2-SHP2 association. Reason: Generic protein binding is uninformative. The binary assay does not resolve the SH2/phosphotyrosine mechanism, so the conservative informative replacement is GO:0019903 protein phosphatase binding (partner is the tyrosine phosphatase SHP2); the mechanistic SH2-domain interaction is documented by Hadari et al. 1998. Proposed replacements: protein phosphatase binding Supporting Evidence: PMID:9632781 we demonstrate that FRS2 forms a complex with the N-terminal SH2 domain of the protein tyrosine phosphatase Shp2 in response to FGF stimulation |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | MODIFY | Summary: IPI with FGFR1 (PMID:35384245). Generic 'protein binding' is uninformative; the interaction is the well-characterized direct PTB-domain binding of FRS2 to the FGFR1 juxtamembrane region. Source is a high-throughput RTK interactome atlas. Reason: Per curation policy, replace generic protein binding with the informative receptor-binding term already supported for FRS2 (GO:0005104 fibroblast growth factor receptor binding). Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation |
| GO:0005515 protein binding | IPI PMID:9632781 Binding of Shp2 tyrosine phosphatase to FRS2 is essential fo... | MODIFY | Summary: IPI with PTPN11/SHP2. Hadari et al. 1998 showed that FGF-stimulated, tyrosine-phosphorylated FRS2 binds the N-terminal SH2 domain of SHP2, and SHP2 in turn recruits additional GRB2. Reason: Generic protein binding is uninformative. The paper specifically maps the interaction to the SHP2 N-terminal SH2 domain, so GO:0042169 SH2 domain binding captures the mechanism (FRS2 phosphotyrosines are SH2 ligands for SHP2 and GRB2). Proposed replacements: SH2 domain binding Supporting Evidence: PMID:9632781 we demonstrate that FRS2 forms a complex with the N-terminal SH2 domain of the protein tyrosine phosphatase Shp2 in response to FGF stimulation PMID:9632781 These experiments demonstrate that FRS2 recruits Grb2 molecules both directly and indirectly via complex formation with Shp2 |
| GO:0005515 protein binding | IPI PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | MODIFY | Summary: IPI with FGFR1 (PMID:9660748). Generic 'protein binding' is uninformative; the interaction is the well-characterized direct PTB-domain binding of FRS2 to the FGFR1 juxtamembrane region. Reason: Per curation policy, replace generic protein binding with the informative receptor-binding term already supported for FRS2 (GO:0005104 fibroblast growth factor receptor binding). Proposed replacements: fibroblast growth factor receptor binding Supporting Evidence: PMID:9660748 we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1) PMID:10629055 While FGFR1 interacts with FRS2 constitutively, independent of ligand stimulation and tyrosine phosphorylation, NGF receptor (TrkA) binding to FRS2 is strongly dependent on receptor activation |
| GO:0005737 cytoplasm | IEA GO_REF:0000107 | ACCEPT | Summary: FRS2 is a peripheral membrane protein on the cytoplasmic face of the plasma membrane; cytoplasm is a broad but not incorrect location transferred from mouse Frs2. Reason: Broad IEA location consistent with its cytoplasmic-face membrane association; plasma membrane is the more informative location. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation |
| GO:0005829 cytosol | TAS Reactome:R-HSA-170964 | MARK AS OVER ANNOTATED | Summary: Reactome (Reactome:R-HSA-170964) places FRS2 in the cytosol for neurotrophin (TrkA/TrkB) receptor reactions, whereas the FGFR reactions place it at the plasma membrane. Reason: FRS2 is N-myristoylated and myristoylation is required for its membrane localization and signalling; its signalling pool acts at the cytoplasmic face of the plasma membrane bound to receptors, not free in the cytosol. The cytosol compartment in these Reactome events reflects compartment modelling of the soluble reaction partners rather than evidence for a cytosolic FRS2 pool. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation |
| GO:0005829 cytosol | TAS Reactome:R-HSA-170977 | MARK AS OVER ANNOTATED | Summary: Reactome (Reactome:R-HSA-170977) places FRS2 in the cytosol for neurotrophin (TrkA/TrkB) receptor reactions, whereas the FGFR reactions place it at the plasma membrane. Reason: FRS2 is N-myristoylated and myristoylation is required for its membrane localization and signalling; its signalling pool acts at the cytoplasmic face of the plasma membrane bound to receptors, not free in the cytosol. The cytosol compartment in these Reactome events reflects compartment modelling of the soluble reaction partners rather than evidence for a cytosolic FRS2 pool. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation |
| GO:0005829 cytosol | TAS Reactome:R-HSA-170978 | MARK AS OVER ANNOTATED | Summary: Reactome (Reactome:R-HSA-170978) places FRS2 in the cytosol for neurotrophin (TrkA/TrkB) receptor reactions, whereas the FGFR reactions place it at the plasma membrane. Reason: FRS2 is N-myristoylated and myristoylation is required for its membrane localization and signalling; its signalling pool acts at the cytoplasmic face of the plasma membrane bound to receptors, not free in the cytosol. The cytosol compartment in these Reactome events reflects compartment modelling of the soluble reaction partners rather than evidence for a cytosolic FRS2 pool. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9028730 | MARK AS OVER ANNOTATED | Summary: Reactome (Reactome:R-HSA-9028730) places FRS2 in the cytosol for neurotrophin (TrkA/TrkB) receptor reactions, whereas the FGFR reactions place it at the plasma membrane. Reason: FRS2 is N-myristoylated and myristoylation is required for its membrane localization and signalling; its signalling pool acts at the cytoplasmic face of the plasma membrane bound to receptors, not free in the cytosol. The cytosol compartment in these Reactome events reflects compartment modelling of the soluble reaction partners rather than evidence for a cytosolic FRS2 pool. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9032073 | MARK AS OVER ANNOTATED | Summary: Reactome (Reactome:R-HSA-9032073) places FRS2 in the cytosol for neurotrophin (TrkA/TrkB) receptor reactions, whereas the FGFR reactions place it at the plasma membrane. Reason: FRS2 is N-myristoylated and myristoylation is required for its membrane localization and signalling; its signalling pool acts at the cytoplasmic face of the plasma membrane bound to receptors, not free in the cytosol. The cytosol compartment in these Reactome events reflects compartment modelling of the soluble reaction partners rather than evidence for a cytosolic FRS2 pool. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Plasma membrane (IEA); FRS2 is a myristoyl-anchored docking protein at the inner leaflet of the plasma membrane. Reason: Myristoylation-dependent plasma-membrane localization is required for FRS2 tyrosine phosphorylation and effector recruitment; this is the core location of FRS2 function. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:9660748 Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras |
| GO:0005886 plasma membrane | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | ACCEPT | Summary: Plasma membrane (TAS); FRS2 is a myristoyl-anchored docking protein at the inner leaflet of the plasma membrane. Reason: Myristoylation-dependent plasma-membrane localization is required for FRS2 tyrosine phosphorylation and effector recruitment; this is the core location of FRS2 function. Supporting Evidence: PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:9660748 Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: Reactome event Reactome:R-HSA-109699 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: Reactome event Reactome:R-HSA-2316434 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: Reactome event Reactome:R-HSA-2400009 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654392 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654397 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654397 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654399 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654399 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654408 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654408 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654409 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654409 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654413 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654413 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654416 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654416 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654418 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654418 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654422 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654422 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654560 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654560 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654562 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654562 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654565 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654565 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654566 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654566 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654569 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654569 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654575 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654575 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654584 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654584 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654586 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654587 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654587 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654591 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654591 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654592 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654592 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654594 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654594 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654596 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654596 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654607 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654607 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654608 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654608 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654612 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654614 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654615 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654618 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654620 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654622 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654631 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654631 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654633 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654633 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654637 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654637 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654640 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654640 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654641 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654641 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654643 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654643 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654655 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654655 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654658 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654658 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654659 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654659 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654662 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654662 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654663 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654663 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654664 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654664 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654667 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654667 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654669 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654669 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654672 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654672 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654673 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654673 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654677 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654679 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654679 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654684 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654684 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654690 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654690 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654692 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654692 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654697 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654701 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654705 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654705 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654709 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654709 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654714 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654714 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654717 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654717 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654729 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654730 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654730 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5654734 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5654734 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655233 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655235 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655235 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655240 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655240 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655241 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655245 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655248 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655248 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655252 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655252 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655262 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655262 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655263 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655263 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655266 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655266 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655268 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655268 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655269 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655269 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655270 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655270 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655277 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655277 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655278 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655278 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655284 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655284 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655285 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655285 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655289 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655289 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655290 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655290 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655295 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655295 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655315 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655315 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655320 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655323 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655326 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655326 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655339 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655339 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655347 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655347 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655348 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655348 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5655351 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5655351 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Reactome event Reactome:R-HSA-5672965 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-8855564 | ACCEPT | Summary: Reactome event Reactome:R-HSA-8855564 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9696266 | ACCEPT | Summary: Reactome event Reactome:R-HSA-9696266 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9696271 | ACCEPT | Summary: Reactome event Reactome:R-HSA-9696271 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9712081 | ACCEPT | Summary: Reactome event Reactome:R-HSA-9712081 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9712087 | ACCEPT | Summary: Reactome event Reactome:R-HSA-9712087 places FRS2 (in FGFR/receptor-bound signalling complexes) at the plasma membrane. Reason: Consistent with the experimentally established myristoyl-dependent plasma-membrane localization of FRS2 at activated receptors. Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation Reactome:R-HSA-5654399 Membrane-bound FRS2 interacts with FGFR as a first step in the phosphorylation of this docking protein. |
| GO:0005911 cell-cell junction | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Cell-cell junction (IBA); derives ultimately from high-throughput E-cadherin proximity-biotinylation (adherens junction) data in human/mouse. Reason: FRS2 is plausibly present near cadherin junctions (proximity proteomics), but this is not where its defined adaptor function has been characterized; retained as non-core location. Supporting Evidence: PMID:25468996 we employed proximity biotinylation and quantitative proteomics to isolate and identify 612 proteins in the vicinity of E-cadherin |
| GO:0005911 cell-cell junction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Cell-cell junction (IEA); derives ultimately from high-throughput E-cadherin proximity-biotinylation (adherens junction) data in human/mouse. Reason: FRS2 is plausibly present near cadherin junctions (proximity proteomics), but this is not where its defined adaptor function has been characterized; retained as non-core location. Supporting Evidence: PMID:25468996 we employed proximity biotinylation and quantitative proteomics to isolate and identify 612 proteins in the vicinity of E-cadherin |
| GO:0005912 adherens junction | IDA PMID:25468996 E-cadherin interactome complexity and robustness resolved by... | KEEP AS NON CORE | Summary: Adherens junction IDA from an E-cadherin proximity-biotinylation (BioID-type) interactome study with GFP-tag localization of selected hits. Reason: High-throughput proximity/localization evidence; the curator saw the full data (supplementary tables are not in the cache). Proximity to the E-cadherin tail does not establish a junctional function, so kept as non-core. Supporting Evidence: PMID:25468996 we employed proximity biotinylation and quantitative proteomics to isolate and identify 612 proteins in the vicinity of E-cadherin PMID:25468996 through cloning and expression of GFP-tagged fusion proteins we localized 26 of the novel proteins to adherens junctions |
| GO:0007185 cell surface receptor protein tyrosine phosphatase signaling pathway | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | REMOVE | Summary: Cell surface receptor protein tyrosine phosphatase signaling pathway (TAS, Xu et al. 1998). Reason: FRS2 associates with SHP2 (PTPN11), a cytoplasmic non-receptor tyrosine phosphatase, downstream of receptor tyrosine kinases. Neither the cited paper nor the wider literature places FRS2 in a pathway initiated by a receptor-type protein tyrosine phosphatase; the TAS appears to conflate SHP2 recruitment with receptor-PTP signalling. Supporting Evidence: PMID:9660748 Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras PMID:9632781 we demonstrate that FRS2 forms a complex with the N-terminal SH2 domain of the protein tyrosine phosphatase Shp2 in response to FGF stimulation |
| GO:0007186 G protein-coupled receptor signaling pathway | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | REMOVE | Summary: G protein-coupled receptor signaling pathway (TAS, Xu et al. 1998). Reason: The cited paper concerns FGFR1-SNT binding and does not address GPCR signalling; FRS2 functions downstream of receptor tyrosine kinases. No evidence supports FRS2 participation in GPCR-initiated signalling. Supporting Evidence: PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: FGF receptor signaling pathway (IBA). FRS2 is the principal FGFR docking protein, directly linking the receptor to Ras-MAPK and PI3K-AKT outputs. Reason: FRS2 performs a step of the pathway (receptor-proximal adaptor), satisfying participation; it is the defining FGFR-specific adaptor. IBA at the FRS2/FRS3 node is sound. Supporting Evidence: PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:11353842 we demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: FGF receptor signaling pathway (IEA). FRS2 is the principal FGFR docking protein, directly linking the receptor to Ras-MAPK and PI3K-AKT outputs. Reason: FRS2 performs a step of the pathway (receptor-proximal adaptor), satisfying participation; it is the defining FGFR-specific adaptor. IBA at the FRS2/FRS3 node is sound. Supporting Evidence: PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:11353842 we demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase |
| GO:0008543 fibroblast growth factor receptor signaling pathway | IGI PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | ACCEPT | Summary: IGI with FGFR1: FGFR-mediated SNT/FRS2 tyrosine phosphorylation requires both the FGFR1 juxtamembrane segment and the FRS2 PTB domain. Reason: FRS2 performs a step of the pathway (receptor-proximal adaptor), satisfying participation; it is the defining FGFR-specific adaptor. IBA at the FRS2/FRS3 node is sound. Supporting Evidence: PMID:9660748 FGFR-mediated SNT tyrosine phosphorylation in vivo requires these segments of receptor and SNT PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways |
| GO:0008543 fibroblast growth factor receptor signaling pathway | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | ACCEPT | Summary: FGF receptor signaling pathway (TAS). FRS2 is the principal FGFR docking protein, directly linking the receptor to Ras-MAPK and PI3K-AKT outputs. Reason: FRS2 performs a step of the pathway (receptor-proximal adaptor), satisfying participation; it is the defining FGFR-specific adaptor. IBA at the FRS2/FRS3 node is sound. Supporting Evidence: PMID:9660748 Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:11353842 we demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, resulting in the recruitment and activation of PI3-kinase |
| GO:0012505 endomembrane system | IEA GO_REF:0000044 | MODIFY | Summary: Endomembrane system, mapped from the UniProt subcellular location vocabulary ('Endomembrane system; cytoplasmic, membrane-bound'). Reason: The UniProt keyword mapping is vague. The experimental evidence places the functional FRS2 pool specifically at the plasma membrane via N-myristoylation; plasma membrane is the appropriate location term. Proposed replacements: plasma membrane Supporting Evidence: PMID:9182757 FRS2 functions as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with the MAPK and other signaling pathways essential for cell growth and differentiation PMID:9182757 We find that FRS2 is myristylated and that this modification is essential for membrane localization, tyrosine phosphorylation, Grb2/Sos recruitment, and MAPK activation |
| GO:0016020 membrane | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | ACCEPT | Summary: Membrane (TAS). The paper describes FRS2/SNT-1 as a membrane-anchored adapter protein. Reason: Correct but general; plasma membrane (GO:0005886) is the specific location and is separately annotated. Supporting Evidence: PMID:9660748 Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras |
| GO:0019211 phosphatase activator activity | TAS PMID:9660748 Novel recognition motif on fibroblast growth factor receptor... | MARK AS OVER ANNOTATED | Summary: Phosphatase activator activity (TAS, Xu et al. 1998). Tyrosine-phosphorylated FRS2 recruits SHP2 via the SHP2 N-terminal SH2 domain. Reason: SH2-phosphopeptide engagement can relieve SHP2 autoinhibition, so activation is mechanistically plausible, but the cited abstract only shows association with Shp-2, and the characterized role of the FRS2-SHP2 complex is recruitment of additional GRB2 (SHP2 acting as an adaptor). Direct stimulation of SHP2 catalytic activity by FRS2 is not demonstrated in the cited work. Supporting Evidence: PMID:9660748 Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras PMID:9632781 These experiments demonstrate that FRS2 recruits Grb2 molecules both directly and indirectly via complex formation with Shp2 |
| GO:2000726 negative regulation of cardiac muscle cell differentiation | IGI PMID:23939491 Overexpression of microRNA-1 promotes cardiomyocyte commitme... | KEEP AS NON CORE | Summary: IGI (with FZD7) from a study showing miR-1 promotes cardiomyocyte commitment from human cardiovascular progenitors by targeting FZD7 and FRS2, thereby dampening WNT and FGF signalling. Reason: Deferring to the curator on the genetic interaction (abstract-only cache). The effect is an indirect, context-specific consequence of FRS2's general FGFR adaptor role (FGF signalling opposes cardiomyocyte commitment in this system) rather than a dedicated FRS2 function. Supporting Evidence: PMID:23939491 FZD7 and FRS2 were confirmed as miR-1 targets using luciferase reporter assay and western blot PMID:23939491 we found miR-1 promoted CM differentiation and suppressed EC commitment from MCPs by modulating the activities of WNT and FGF signaling pathways |
Loading supporting content…
Download this section (compressed HTML)Q: Should FRS2 carry GO:0048011 neurotrophin TRK receptor signaling pathway? Meakin et al. 1999 shows FRS-2 reconstitutes NGF-induced differentiation, which is participation evidence, yet comparable Trk adaptors (SHC1) and mouse Frs2 lack the term; is this a deliberate convention or a gap?
Q: What fraction of FRS2 signalling in vivo goes through non-FGFR RTKs (TrkA/B/C, RET, ALK, EGFR), and is FRS2 redundant with FRS3 or SHC1 at these receptors?
Q: Does binding of bisphosphorylated FRS2 directly stimulate SHP2 catalytic activity, or does SHP2 act only as a GRB2-recruiting adaptor in the FRS2 complex?
Q: Is the adherens-junction proximity of FRS2 functionally relevant (e.g. FGFR-cadherin crosstalk), or a by-product of plasma-membrane localization?
Experiment: Knock-in of PTB-domain mutants that selectively abolish FGFR (non-pY) versus Trk (NPXpY) binding, to separate FRS2's FGFR and neurotrophin adaptor roles in neurons.
Experiment: Purified-component assay of SHP2 phosphatase activity in the presence of tyrosine-phosphorylated FRS2 tail peptides to test whether FRS2 has phosphatase activator activity.
Experiment: Conditional combined FRS2/FRS3 deletion in RET-dependent enteric neural crest or kidney to test whether FRS2 is required for GDNF-RET signalling in vivo.
Loading supporting content…
Download this section (compressed HTML)Loading supporting content…
Download this section (compressed HTML)Loading supporting content…
Download this section (compressed HTML)