Frizzled-7 (FZD7) is a seven-transmembrane receptor belonging to the class F G-protein coupled receptor family. It functions as the primary receptor for Wnt ligands, transducing both canonical Wnt/beta-catenin signaling and non-canonical Wnt signaling pathways (planar cell polarity/PCP and Wnt/Ca2+). The receptor contains an extracellular cysteine-rich domain (CRD) that binds Wnt proteins, a seven-transmembrane core, and a C-terminal PDZ-binding motif that recruits Dishevelled (DVL) and other PDZ domain-containing proteins. A 1.9 Γ cryo-EM structure of inactive human FZD7 (Bous et al. 2024) identified an internal water pocket and a conserved cholesterol-binding site (F3.34/H4.46/W4.50) that is required for FZD7-DVL association and downstream signalosome formation; a R6.32-W7.55 micro-switch acts as a hinge limiter on TM6 opening, biasing the receptor toward DVL coupling over heterotrimeric G proteins. Surface levels of FZD7 are negatively regulated by RNF43-mediated ubiquitination and endocytosis. FZD7 is essential for human embryonic stem cell self-renewal, skeletal muscle satellite stem cell maintenance, and postnatal angiogenesis. It is frequently overexpressed in multiple cancers where it drives tumor progression through Wnt pathway activation. FZD7 also serves as a receptor for C. difficile toxin B in colonic epithelium.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005886 plasma membrane | IDA PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports... | ACCEPT | Summary: Direct experimental evidence from microscopy showing FZD7 at plasma membrane. K569 is essential for SDCBP-mediated plasma membrane PIP2 recognition. Multiple independent IDA studies confirm this localization. Supporting Evidence: PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. |
| GO:0055038 recycling endosome membrane | IDA PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports... | KEEP AS NON CORE | Summary: FZD7 localizes to recycling endosomes in absence of PIP2/SDCBP interaction. Part of receptor trafficking, not core functional location. Supporting Evidence: PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. |
| GO:0016020 membrane | IEA GO_REF:0000002 | REMOVE | Summary: Too general. Plasma membrane annotation is more specific. |
| GO:0010008 endosome membrane | IEA GO_REF:0000044 | REMOVE | Summary: Too general. Recycling endosome membrane annotation is more specific. |
| GO:0042813 Wnt receptor activity | IDA PMID:28733458 Mapping of Wnt-Frizzled interactions by multiplex CRISPR tar... | ACCEPT | Summary: FZD7 is a bona fide Wnt receptor. Demonstrated through CRISPR mapping studies and extensive literature showing Wnt ligand binding and signal transduction. This is the core molecular function of FZD7. Supporting Evidence: PMID:28733458 Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. PMID:9707618 A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. PMID:18313787 Feb 7. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. file:human/FZD7/FZD7-deep-research-perplexity.md file:human/FZD7/FZD7-deep-research-falcon.md FZD7's primary molecular role is as a plasma-membrane WNT receptor that couples extracellular WNT ligand recognition to intracellular signaling by recruiting transducersβparticularly DVLβand in some contexts engaging heterotrimeric G proteins |
| GO:0017147 Wnt-protein binding | IPI PMID:18313787 Functional interaction between Wnt3 and Frizzled-7 leads to ... | ACCEPT | Summary: Direct binding to Wnt3 demonstrated by co-immunoprecipitation. The extracellular CRD domain binds Wnt ligands. Supporting Evidence: PMID:18313787 Feb 7. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. |
| GO:0030165 PDZ domain binding | IPI PMID:19388021 Sequence requirement and subtype specificity in the high-aff... | ACCEPT | Summary: FZD7 C-terminal KTXXXW motif binds PDZ domains of DVL, SDCBP/syntenin, NHERF1, and other PDZ proteins. Critical for signal transduction. Supporting Evidence: PMID:19388021 Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. |
| GO:0005546 phosphatidylinositol-4,5-bisphosphate binding | IDA PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports... | ACCEPT | Summary: FZD7 binds PIP2 via SDCBP-mediated interaction at plasma membrane. K569 is essential for this function. Supporting Evidence: PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. |
| GO:0004930 G protein-coupled receptor activity | IEA GO_REF:0000043 | KEEP AS NON CORE | Summary: FZD7 is structurally a class F GPCR. However, its primary signaling is through DVL rather than classical G protein coupling. Structural work shows a R6.32-W7.55 micro-switch acting as a hinge limiter that restricts TM6 opening, rationalizing the modest coupling to heterotrimeric G proteins. Keep as structural classification. Supporting Evidence: PMID:39198452 the molecular switch R6.32-W7.55 acts as a hinge limiter (Fig. 3c, d) permitting only a restricted TM6 opening (11Β°, 5.5 Γ
). Hence, the open conformation of FZDs remains suboptimal for G protein coupling providing a rational explanation for the limited capacity of FZDs to couple to heterotrimeric G proteins and their propensity to display selectivity towards DVL over heterotrimeric G proteins PMID:37516754 prefer coupling to DVL rather than heterotrimeric |
| GO:0004888 transmembrane signaling receptor activity | IEA GO_REF:0000002 | REMOVE | Summary: Too general. Wnt receptor activity is more specific. |
| GO:0005109 frizzled binding | IPI PMID:19188438 Myocilin is a modulator of Wnt signaling | REMOVE | Summary: This annotation reflects that MYOC binds FZD7, not that FZD7 binds other Frizzled receptors. Should be captured on MYOC entry instead. Supporting Evidence: PMID:19188438 Feb 2. Myocilin is a modulator of Wnt signaling. |
| GO:0005515 protein binding | IPI PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports... | REMOVE | Summary: Protein binding is uninformative per GO curation guidelines. FZD7 binds multiple proteins including SDCBP, DVL, NHERF1, Wnt3 - captured by more specific terms (PDZ domain binding, Wnt-protein binding). Supporting Evidence: PMID:27386966 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:28733458 Mapping of Wnt-Frizzled interactions by multiplex CRISPR tar... | ACCEPT | Summary: FZD7 transduces canonical Wnt/beta-catenin signaling. This leads to beta-catenin stabilization, nuclear translocation, and TCF/LEF-mediated transcription. Core biological process. Supporting Evidence: PMID:28733458 Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. PMID:9707618 A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. PMID:20802536 Direct interaction between NHERF1 and Frizzled regulates Ξ²-catenin signaling. PMID:18215320 Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. PMID:18313787 Feb 7. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. |
| GO:0035567 non-canonical Wnt signaling pathway | IMP PMID:19773752 Down-regulation of frizzled-7 expression decreases survival,... | ACCEPT | Summary: FZD7 transduces non-canonical Wnt signaling including JNK/RhoA pathway. FZD7 knockdown decreases RhoA activation and JNK phosphorylation. Core biological process alongside canonical signaling. Supporting Evidence: PMID:19773752 2009 Sep 22. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. PMID:26126266 Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. |
| GO:0060071 Wnt signaling pathway, planar cell polarity pathway | NAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | KEEP AS NON CORE | Summary: FZD7 signals through PCP pathway via Vangl2, RhoA/Rac1. Part of non-canonical Wnt signaling. Keep as specific subtype. Supporting Evidence: PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. |
| GO:0016055 Wnt signaling pathway | IEA GO_REF:0000043 | REMOVE | Summary: Too general. More specific canonical and non-canonical annotations present. |
| GO:0007165 signal transduction | IEA GO_REF:0000043 | REMOVE | Summary: Too general. Wnt pathway terms are more specific. |
| GO:0007166 cell surface receptor signaling pathway | IEA GO_REF:0000002 | REMOVE | Summary: Too general. Captured by Wnt signaling pathway annotations. |
| GO:0007186 G protein-coupled receptor signaling pathway | IEA GO_REF:0000043 | REMOVE | Summary: FZD7 signals primarily through DVL, not classical G proteins. Wnt pathway terms are more accurate. |
| GO:0060828 regulation of canonical Wnt signaling pathway | IMP PMID:9707618 A novel frizzled gene identified in human esophageal carcino... | REMOVE | Summary: Redundant with GO:0060070 canonical Wnt signaling pathway. Supporting Evidence: PMID:9707618 A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |
| GO:0043410 positive regulation of MAPK cascade | IMP PMID:19773752 Down-regulation of frizzled-7 expression decreases survival,... | KEEP AS NON CORE | Summary: FZD7 knockdown decreases JNK phosphorylation. Part of non-canonical Wnt signaling (JNK/PCP pathway). Downstream effect. Supporting Evidence: PMID:19773752 2009 Sep 22. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. |
| GO:0046330 positive regulation of JNK cascade | IC PMID:18256285 The postsynaptic density 95/disc-large/zona occludens protei... | KEEP AS NON CORE | Summary: Part of non-canonical Wnt signaling. FZD7 activates JNK through DVL/RhoA. Supporting Evidence: PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. PMID:19773752 2009 Sep 22. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. |
| GO:0019827 stem cell population maintenance | IMP PMID:18681827 The WNT receptor FZD7 contributes to self-renewal signaling ... | ACCEPT | Summary: FZD7 is essential for hESC self-renewal. Knockdown causes rapid loss of OCT4 and differentiation. Critical developmental/stem cell role. Supporting Evidence: PMID:18681827 The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. |
| GO:0042666 negative regulation of ectodermal cell fate specification | IMP PMID:18681827 The WNT receptor FZD7 contributes to self-renewal signaling ... | KEEP AS NON CORE | Summary: FZD7 knockdown in hESCs leads to perturbation of germ layer markers. Part of stem cell maintenance function. Supporting Evidence: PMID:18681827 The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. |
| GO:0006355 regulation of DNA-templated transcription | IMP PMID:18681827 The WNT receptor FZD7 contributes to self-renewal signaling ... | REMOVE | Summary: Downstream consequence of Wnt signaling. Too general. Supporting Evidence: PMID:18681827 The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. |
| GO:0045893 positive regulation of DNA-templated transcription | IDA PMID:18215320 Ror2 modulates the canonical Wnt signaling in lung epithelia... | REMOVE | Summary: Downstream effect of Wnt signaling. Too general. Supporting Evidence: PMID:18215320 Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. |
| GO:0060231 mesenchymal to epithelial transition | IMP PMID:17016432 Frizzled-7 dictates three-dimensional organization of colore... | KEEP AS NON CORE | Summary: FZD7 regulates 3D organization in colorectal cancer cells. Context-dependent phenotypic outcome. Supporting Evidence: PMID:17016432 Oct 2. Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. |
| GO:0010812 negative regulation of cell-substrate adhesion | IMP PMID:18156211 Regulation of endothelial cell cytoskeletal reorganization b... | KEEP AS NON CORE | Summary: FZD7 effects on cell adhesion in epithelial cells. Downstream phenotypic effect. Supporting Evidence: PMID:18156211 Dec 21. Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. |
| GO:2000726 negative regulation of cardiac muscle cell differentiation | IGI PMID:23939491 Overexpression of microRNA-1 promotes cardiomyocyte commitme... | KEEP AS NON CORE | Summary: FZD7 suppresses cardiomyocyte differentiation via Wnt signaling. Supporting Evidence: PMID:23939491 2013 Aug 9. Overexpression of microRNA-1 promotes cardiomyocyte commitment from human cardiovascular progenitors via suppressing WNT and FGF signaling pathways. |
| GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing | IMP PMID:18313787 Functional interaction between Wnt3 and Frizzled-7 leads to ... | KEEP AS NON CORE | Summary: Wnt3-FZD7 signaling promotes epithelial cell proliferation in HCC context. Supporting Evidence: PMID:18313787 Feb 7. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. |
| GO:0042327 positive regulation of phosphorylation | IDA PMID:18256285 The postsynaptic density 95/disc-large/zona occludens protei... | REMOVE | Summary: Too general. FZD7 activates downstream kinases as part of signaling. Supporting Evidence: PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. |
| GO:0030182 neuron differentiation | ISS GO_REF:0000024 | UNDECIDED | Summary: Inferred from sequence similarity. FZD7 likely involved in neuron differentiation but evidence is indirect. |
| GO:0071300 cellular response to retinoic acid | ISS GO_REF:0000024 | UNDECIDED | Summary: Inferred from sequence similarity. Indirect evidence only. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic annotation. Consolidated with IDA evidence above. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-3858482 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence above. |
| GO:0005886 plasma membrane | IEA GO_REF:0000120 | ACCEPT | Summary: Electronic annotation. Consolidated with IDA evidence above. |
| GO:0016020 membrane | TAS PMID:9707618 A novel frizzled gene identified in human esophageal carcino... | REMOVE | Summary: Too general. Plasma membrane is more specific. Supporting Evidence: PMID:9707618 A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |
| GO:0042813 Wnt receptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: Electronic annotation. Consolidated with IDA evidence above. |
| GO:0042813 Wnt receptor activity | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic annotation. Consolidated with IDA evidence above. |
| GO:0042813 Wnt receptor activity | NAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | ACCEPT | Summary: Author statement. Consolidated with IDA evidence above. Supporting Evidence: PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. |
| GO:0017147 Wnt-protein binding | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic annotation. Consolidated with IPI evidence above. |
| GO:0017147 Wnt-protein binding | NAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | ACCEPT | Summary: Author statement. Consolidated with IPI evidence above. Supporting Evidence: PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease. |
| GO:0017147 Wnt-protein binding | IEA GO_REF:0000107 | ACCEPT | Summary: Electronic annotation. Consolidated with IPI evidence above. |
| GO:0030165 PDZ domain binding | IEA GO_REF:0000117 | ACCEPT | Summary: ARBA rule annotation. Consolidated with IPI evidence above. |
| GO:0030165 PDZ domain binding | IPI PMID:18256285 The postsynaptic density 95/disc-large/zona occludens protei... | ACCEPT | Summary: Interaction with syntenin. Consolidated with IPI evidence above. Supporting Evidence: PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. |
| GO:0060070 canonical Wnt signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic annotation. Consolidated with IDA evidence above. |
| GO:0060070 canonical Wnt signaling pathway | IEA GO_REF:0000117 | ACCEPT | Summary: ARBA rule annotation. Consolidated with IDA evidence above. |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:19773752 Down-regulation of frizzled-7 expression decreases survival,... | ACCEPT | Summary: Mutant phenotype. Consolidated with IDA evidence above. Supporting Evidence: PMID:19773752 2009 Sep 22. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. |
| GO:0060070 canonical Wnt signaling pathway | IMP PMID:18313787 Functional interaction between Wnt3 and Frizzled-7 leads to ... | ACCEPT | Summary: Mutant phenotype. Consolidated with IDA evidence above. Supporting Evidence: PMID:18313787 Feb 7. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. |
| GO:0035567 non-canonical Wnt signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: Phylogenetic annotation. Consolidated with IMP evidence above. |
| GO:0010812 negative regulation of cell-substrate adhesion | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Electronic annotation. Consolidated with IMP evidence above. |
| GO:0045893 positive regulation of DNA-templated transcription | IMP PMID:19773752 Down-regulation of frizzled-7 expression decreases survival,... | REMOVE | Summary: Downstream effect of Wnt signaling. Too general. Supporting Evidence: PMID:19773752 2009 Sep 22. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9673284 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9673288 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9673296 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9673349 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9673794 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9673797 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | TAS Reactome:R-NUL-1504194 | ACCEPT | Summary: Reactome pathway annotation. Consolidated with IDA evidence. |
| GO:0005886 plasma membrane | IDA PMID:18256285 The postsynaptic density 95/disc-large/zona occludens protei... | ACCEPT | Summary: Direct assay evidence. Consolidated with other IDA evidence. Supporting Evidence: PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. |
| GO:0005886 plasma membrane | IDA GO_REF:0000054 | ACCEPT | Summary: LIFEdb annotation. Consolidated with IDA evidence. |
| GO:0015485 cholesterol binding | IDA PMID:39198452 Structural basis of frizzled 7 activation and allosteric reg... | NEW | Summary: Bous et al. 2024 identified a conserved cholesterol-binding site on the FZD7 surface (TM2-TM4; F3.34/H4.46/W4.50) by cryo-EM and demonstrated with double mutants that disruption abolishes DEP recruitment and reduces WNT-3A-induced TOPFlash, indicating a direct functional role for cholesterol binding in DVL recruitment and signaling. Proposed new annotation. Supporting Evidence: PMID:39198452 we identified a conserved cholesterol-binding site involving W4.50 (BallesterosβWeinstein numbering) |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:20802536 Direct interaction between NHERF1 and Frizzled regulates Ξ²-c... | ACCEPT | Summary: Direct assay evidence. Consolidated with other IDA evidence. Supporting Evidence: PMID:20802536 Direct interaction between NHERF1 and Frizzled regulates Ξ²-catenin signaling. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:18215320 Ror2 modulates the canonical Wnt signaling in lung epithelia... | ACCEPT | Summary: Direct assay evidence. Consolidated with other IDA evidence. Supporting Evidence: PMID:18215320 Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. |
| GO:0005515 protein binding | IPI PMID:26126266 Daple is a novel non-receptor GEF required for trimeric G pr... | REMOVE | Summary: Interaction with DAPLE. Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:26126266 Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling. |
| GO:0005515 protein binding | IPI PMID:18256285 The postsynaptic density 95/disc-large/zona occludens protei... | REMOVE | Summary: Interaction with syntenin. Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:18256285 2008 Feb 6. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. |
| GO:0005515 protein binding | IPI PMID:18313787 Functional interaction between Wnt3 and Frizzled-7 leads to ... | REMOVE | Summary: Interaction with Wnt3. Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:18313787 Feb 7. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. |
| GO:0005515 protein binding | IPI PMID:27680706 Frizzled proteins are colonic epithelial receptors for C. di... | REMOVE | Summary: Interaction with TcdB toxin. Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:27680706 Frizzled proteins are colonic epithelial receptors for C. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:16189514 Towards a proteome-scale map of the human protein-protein interaction network. |
| GO:0005515 protein binding | IPI PMID:21314951 Soluble Frizzled-7 receptor inhibits Wnt signaling and sensi... | REMOVE | Summary: Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:21314951 Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. |
| GO:0005515 protein binding | IPI PMID:28298427 Systematic protein-protein interaction mapping for clinicall... | REMOVE | Summary: Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:28298427 Systematic protein-protein interaction mapping for clinically relevant human GPCRs. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:31515488 Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Protein binding uninformative per GO guidelines. Multiple interactions from same study. Supporting Evidence: PMID:32296183 Apr 8. A reference map of the human binary protein interactome. |
| GO:0005515 protein binding | IPI PMID:36115835 Quantitative fragmentomics allow affinity mapping of interac... | REMOVE | Summary: Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:36115835 Quantitative fragmentomics allow affinity mapping of interactomes. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Protein binding uninformative per GO guidelines. Supporting Evidence: PMID:40205054 Apr 9. Multimodal cell maps as a foundation for structural and functional genomics. |
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Download this section (compressed HTML)Q: What is the relative contribution of FZD7 to canonical versus non-canonical Wnt signaling in different cell types? Are there cell-type-specific co-factors that determine pathway choice?
Experiment: Systematic comparison of Wnt ligand binding affinities to FZD7 using surface plasmon resonance or isothermal calorimetry to determine which Wnts preferentially activate FZD7.
Hypothesis: Different Wnt ligands may preferentially activate canonical or non-canonical pathways through FZD7, but quantitative binding data is limited.
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