GAS6

id: Q14393
gene_symbol: GAS6
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for GAS6'
existing_annotations:
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005509
      label: calcium ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016477
      label: cell migration
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030154
      label: cell differentiation
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031669
      label: cellular response to nutrient levels
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043277
      label: apoptotic cell clearance
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0046872
      label: metal ion binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000270
      label: negative regulation of fibroblast apoptotic process
    evidence_type: IEA
    original_reference_id: GO_REF:0000117
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031100
      label: animal organ regeneration
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032008
      label: positive regulation of TOR signaling
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071333
      label: cellular response to glucose stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0085029
      label: extracellular matrix assembly
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000533
      label: negative regulation of renal albumin absorption
    evidence_type: IEA
    original_reference_id: GO_REF:0000107
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-202710
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005788
      label: endoplasmic reticulum lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-163809
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005788
      label: endoplasmic reticulum lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-8952289
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-163809
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005796
      label: Golgi lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-163843
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0031093
      label: platelet alpha granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-481007
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007166
      label: cell surface receptor signaling pathway
    evidence_type: IDA
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0030674
      label: protein-macromolecule adaptor activity
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0046827
      label: positive regulation of protein export from nucleus
    evidence_type: IDA
    original_reference_id: PMID:18680538
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18680538
          supporting_text: GAS6-induced signaling in human endothelial cells is 
            mediated by FOXO1a.
  - term:
      id: GO:2000352
      label: negative regulation of endothelial cell apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:18680538
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18680538
          supporting_text: GAS6-induced signaling in human endothelial cells is 
            mediated by FOXO1a.
  - term:
      id: GO:0070062
      label: extracellular exosome
    evidence_type: HDA
    original_reference_id: PMID:23533145
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:23533145
          supporting_text: 2013 Apr 23. In-depth proteomic analyses of exosomes 
            isolated from expressed prostatic secretions in urine.
  - term:
      id: GO:0070588
      label: calcium ion transmembrane transport
    evidence_type: IDA
    original_reference_id: PMID:18395422
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18395422
          supporting_text: 2008 Feb 16. Endogenous Gas6 and Ca2+ -channel 
            activation modulate phagocytosis by retinal pigment epithelium.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:18395422
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18395422
          supporting_text: 2008 Feb 16. Endogenous Gas6 and Ca2+ -channel 
            activation modulate phagocytosis by retinal pigment epithelium.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:19922767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19922767
          supporting_text: 2009 Nov 14. GAS6/Mer axis regulates the homing and 
            survival of the E2A/PBX1-positive B-cell precursor acute 
            lymphoblastic leukemia in the bone marrow niche.
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:18395422
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18395422
          supporting_text: 2008 Feb 16. Endogenous Gas6 and Ca2+ -channel 
            activation modulate phagocytosis by retinal pigment epithelium.
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:7854420
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7854420
          supporting_text: Axl receptor tyrosine kinase stimulated by the 
            vitamin K-dependent protein encoded by growth-arrest-specific gene 
            6.
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IPI
    original_reference_id: PMID:7854420
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7854420
          supporting_text: Axl receptor tyrosine kinase stimulated by the 
            vitamin K-dependent protein encoded by growth-arrest-specific gene 
            6.
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IDA
    original_reference_id: PMID:7854420
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7854420
          supporting_text: Axl receptor tyrosine kinase stimulated by the 
            vitamin K-dependent protein encoded by growth-arrest-specific gene 
            6.
  - term:
      id: GO:0045860
      label: positive regulation of protein kinase activity
    evidence_type: IDA
    original_reference_id: PMID:7854420
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7854420
          supporting_text: Axl receptor tyrosine kinase stimulated by the 
            vitamin K-dependent protein encoded by growth-arrest-specific gene 
            6.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:7854420
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7854420
          supporting_text: Axl receptor tyrosine kinase stimulated by the 
            vitamin K-dependent protein encoded by growth-arrest-specific gene 
            6.
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: IDA
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0019064
      label: fusion of virus membrane with host plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0046813
      label: receptor-mediated virion attachment to host cell
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0006909
      label: phagocytosis
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0043277
      label: apoptotic cell clearance
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:1900142
      label: negative regulation of oligodendrocyte apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:16723520
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16723520
          supporting_text: Gas6/Axl signaling activates the phosphatidylinositol
            3-kinase/Akt1 survival pathway to protect oligodendrocytes from 
            tumor necrosis factor alpha-induced apoptosis.
  - term:
      id: GO:0001786
      label: phosphatidylserine binding
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0001961
      label: positive regulation of cytokine-mediated signaling pathway
    evidence_type: IMP
    original_reference_id: PMID:18840707
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18840707
          supporting_text: 2008 Oct 7. The Axl/Gas6 pathway is required for 
            optimal cytokine signaling during human natural killer cell 
            development.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:18760998
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18760998
          supporting_text: Gas6-mediated signaling is dependent on the 
            engagement of its gamma-carboxyglutamic acid domain with 
            phosphatidylserine.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20088931
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20088931
          supporting_text: Epub 2010 Jan 17. Gas6 is complexed to the soluble 
            tyrosine kinase receptor Axl in human blood.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:20088931
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20088931
          supporting_text: Epub 2010 Jan 17. Gas6 is complexed to the soluble 
            tyrosine kinase receptor Axl in human blood.
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IDA
    original_reference_id: PMID:18680538
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18680538
          supporting_text: GAS6-induced signaling in human endothelial cells is 
            mediated by FOXO1a.
  - term:
      id: GO:0010628
      label: positive regulation of gene expression
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0010804
      label: negative regulation of tumor necrosis factor-mediated signaling 
        pathway
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0019079
      label: viral genome replication
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0032689
      label: negative regulation of type II interferon production
    evidence_type: IDA
    original_reference_id: PMID:18840707
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18840707
          supporting_text: 2008 Oct 7. The Axl/Gas6 pathway is required for 
            optimal cytokine signaling during human natural killer cell 
            development.
  - term:
      id: GO:0032692
      label: negative regulation of interleukin-1 production
    evidence_type: IDA
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0032715
      label: negative regulation of interleukin-6 production
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0032720
      label: negative regulation of tumor necrosis factor production
    evidence_type: IDA
    original_reference_id: PMID:20103767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20103767
          supporting_text: TNF-alpha, IL-6, and IL-1 expression is inhibited by 
            GAS6 in monocytes/macrophages.
  - term:
      id: GO:0032825
      label: positive regulation of natural killer cell differentiation
    evidence_type: IDA
    original_reference_id: PMID:18840707
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18840707
          supporting_text: 2008 Oct 7. The Axl/Gas6 pathway is required for 
            optimal cytokine signaling during human natural killer cell 
            development.
  - term:
      id: GO:0035457
      label: cellular response to interferon-alpha
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0035754
      label: B cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:19922767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19922767
          supporting_text: 2009 Nov 14. GAS6/Mer axis regulates the homing and 
            survival of the E2A/PBX1-positive B-cell precursor acute 
            lymphoblastic leukemia in the bone marrow niche.
  - term:
      id: GO:0043066
      label: negative regulation of apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:19922767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19922767
          supporting_text: 2009 Nov 14. GAS6/Mer axis regulates the homing and 
            survival of the E2A/PBX1-positive B-cell precursor acute 
            lymphoblastic leukemia in the bone marrow niche.
  - term:
      id: GO:0045892
      label: negative regulation of DNA-templated transcription
    evidence_type: IDA
    original_reference_id: PMID:18680538
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18680538
          supporting_text: GAS6-induced signaling in human endothelial cells is 
            mediated by FOXO1a.
  - term:
      id: GO:0046718
      label: symbiont entry into host cell
    evidence_type: IDA
    original_reference_id: PMID:21501828
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:21501828
          supporting_text: The soluble serum protein Gas6 bridges virion 
            envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl 
            to mediate viral entry.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:18680538
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18680538
          supporting_text: GAS6-induced signaling in human endothelial cells is 
            mediated by FOXO1a.
  - term:
      id: GO:0070168
      label: negative regulation of biomineral tissue development
    evidence_type: IDA
    original_reference_id: PMID:20048160
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:20048160
          supporting_text: 2010 Jan 4. Androgen receptor-dependent 
            transactivation of growth arrest-specific gene 6 mediates inhibitory
            effects of testosterone on vascular calcification.
  - term:
      id: GO:0097028
      label: dendritic cell differentiation
    evidence_type: IEP
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0097241
      label: hematopoietic stem cell migration to bone marrow
    evidence_type: IDA
    original_reference_id: PMID:19922767
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19922767
          supporting_text: 2009 Nov 14. GAS6/Mer axis regulates the homing and 
            survival of the E2A/PBX1-positive B-cell precursor acute 
            lymphoblastic leukemia in the bone marrow niche.
  - term:
      id: GO:2000352
      label: negative regulation of endothelial cell apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:18760998
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18760998
          supporting_text: Gas6-mediated signaling is dependent on the 
            engagement of its gamma-carboxyglutamic acid domain with 
            phosphatidylserine.
  - term:
      id: GO:2000510
      label: positive regulation of dendritic cell chemotaxis
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:2000669
      label: negative regulation of dendritic cell apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:19657094
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19657094
          supporting_text: Aug 5. Survival and migration of human dendritic 
            cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
  - term:
      id: GO:0043027
      label: cysteine-type endopeptidase inhibitor activity involved in 
        apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:16723520
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16723520
          supporting_text: Gas6/Axl signaling activates the phosphatidylinositol
            3-kinase/Akt1 survival pathway to protect oligodendrocytes from 
            tumor necrosis factor alpha-induced apoptosis.
  - term:
      id: GO:0050766
      label: positive regulation of phagocytosis
    evidence_type: IDA
    original_reference_id: PMID:18395422
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:18395422
          supporting_text: 2008 Feb 16. Endogenous Gas6 and Ca2+ -channel 
            activation modulate phagocytosis by retinal pigment epithelium.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:16723520
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16723520
          supporting_text: Gas6/Axl signaling activates the phosphatidylinositol
            3-kinase/Akt1 survival pathway to protect oligodendrocytes from 
            tumor necrosis factor alpha-induced apoptosis.
  - term:
      id: GO:0001934
      label: positive regulation of protein phosphorylation
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003104
      label: positive regulation of glomerular filtration
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032008
      label: positive regulation of TOR signaling
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0032148
      label: activation of protein kinase B activity
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071333
      label: cellular response to glucose stimulus
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0085029
      label: extracellular matrix assembly
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:2000533
      label: negative regulation of renal albumin absorption
    evidence_type: ISS
    original_reference_id: GO_REF:0000024
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: >-
        OVER-ANNOTATION: GAS6 is a secreted LIGAND for the TAM receptor tyrosine kinases
        (AXL, TYRO3, MER). It does NOT have kinase activity itself. GAS6 binding triggers
        receptor autophosphorylation and downstream signaling, but the receptors (not
        GAS6)
        catalyze the phosphorylation. Same pattern as mouse Gas6 (already reviewed).
      action: MODIFY
      proposed_replacement_terms:
        - id: GO:0045859
          label: regulation of protein kinase activity
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:0071307
      label: cellular response to vitamin K
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:0071466
      label: cellular response to xenobiotic stimulus
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:0072659
      label: protein localization to plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:2000270
      label: negative regulation of fibroblast apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:2000352
      label: negative regulation of endothelial cell apoptotic process
    evidence_type: IDA
    original_reference_id: PMID:16359517
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16359517
          supporting_text: The role of gamma-carboxylation in the anti-apoptotic
            function of gas6.
  - term:
      id: GO:0030971
      label: receptor tyrosine kinase binding
    evidence_type: IPI
    original_reference_id: PMID:7634325
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:7634325
          supporting_text: Reevaluation of the roles of protein S and Gas6 as 
            ligands for the receptor tyrosine kinase Rse/Tyro 3.
  - term:
      id: GO:0048018
      label: receptor ligand activity
    evidence_type: IDA
    original_reference_id: PMID:15184064
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15184064
          supporting_text: Vitamin K-dependent Gas6 activates ERK kinase and 
            stimulates growth of cardiac fibroblasts.
  - term:
      id: GO:0048146
      label: positive regulation of fibroblast proliferation
    evidence_type: IDA
    original_reference_id: PMID:15184064
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15184064
          supporting_text: Vitamin K-dependent Gas6 activates ERK kinase and 
            stimulates growth of cardiac fibroblasts.
  - term:
      id: GO:0070374
      label: positive regulation of ERK1 and ERK2 cascade
    evidence_type: IDA
    original_reference_id: PMID:15184064
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15184064
          supporting_text: Vitamin K-dependent Gas6 activates ERK kinase and 
            stimulates growth of cardiac fibroblasts.
  - term:
      id: GO:0005615
      label: extracellular space
    evidence_type: IDA
    original_reference_id: PMID:8336730
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8336730
          supporting_text: The protein encoded by a growth arrest-specific gene 
            (gas6) is a new member of the vitamin K-dependent proteins related 
            to protein S, a negative coregulator in the blood coagulation 
            cascade.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000024
    title: Manual transfer of experimentally-verified manual GO annotation data 
      to orthologs by curator judgment of sequence similarity
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000107
    title: Automatic transfer of experimentally verified manual GO annotation 
      data to orthologs using Ensembl Compara
    findings: []
  - id: GO_REF:0000117
    title: Electronic Gene Ontology annotations created by ARBA machine learning
      models
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:15184064
    title: Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth 
      of cardiac fibroblasts.
    findings: []
  - id: PMID:16359517
    title: The role of gamma-carboxylation in the anti-apoptotic function of 
      gas6.
    findings: []
  - id: PMID:16723520
    title: Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 
      survival pathway to protect oligodendrocytes from tumor necrosis factor 
      alpha-induced apoptosis.
    findings: []
  - id: PMID:18395422
    title: Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by
      retinal pigment epithelium.
    findings: []
  - id: PMID:18680538
    title: GAS6-induced signaling in human endothelial cells is mediated by 
      FOXO1a.
    findings: []
  - id: PMID:18760998
    title: Gas6-mediated signaling is dependent on the engagement of its 
      gamma-carboxyglutamic acid domain with phosphatidylserine.
    findings: []
  - id: PMID:18840707
    title: The Axl/Gas6 pathway is required for optimal cytokine signaling 
      during human natural killer cell development.
    findings: []
  - id: PMID:19657094
    title: Survival and migration of human dendritic cells are regulated by an 
      IFN-alpha-inducible Axl/Gas6 pathway.
    findings: []
  - id: PMID:19922767
    title: GAS6/Mer axis regulates the homing and survival of the 
      E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the 
      bone marrow niche.
    findings: []
  - id: PMID:20048160
    title: Androgen receptor-dependent transactivation of growth arrest-specific
      gene 6 mediates inhibitory effects of testosterone on vascular 
      calcification.
    findings: []
  - id: PMID:20088931
    title: Gas6 is complexed to the soluble tyrosine kinase receptor Axl in 
      human blood.
    findings: []
  - id: PMID:20103767
    title: TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in 
      monocytes/macrophages.
    findings: []
  - id: PMID:21501828
    title: The soluble serum protein Gas6 bridges virion envelope 
      phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate 
      viral entry.
    findings: []
  - id: PMID:23533145
    title: In-depth proteomic analyses of exosomes isolated from expressed 
      prostatic secretions in urine.
    findings: []
  - id: PMID:7634325
    title: Reevaluation of the roles of protein S and Gas6 as ligands for the 
      receptor tyrosine kinase Rse/Tyro 3.
    findings: []
  - id: PMID:7854420
    title: Axl receptor tyrosine kinase stimulated by the vitamin K-dependent 
      protein encoded by growth-arrest-specific gene 6.
    findings: []
  - id: PMID:8336730
    title: The protein encoded by a growth arrest-specific gene (gas6) is a new 
      member of the vitamin K-dependent proteins related to protein S, a 
      negative coregulator in the blood coagulation cascade.
    findings: []
  - id: Reactome:R-HSA-163809
    title: Gamma-carboxy pro-GAS6 transport from the endoplasmic reticulum to 
      the Golgi apparatus
    findings: []
  - id: Reactome:R-HSA-163843
    title: Furin cleaves pro-GAS6 to GAS6
    findings: []
  - id: Reactome:R-HSA-202710
    title: MERTK receptor binds ligands (Gas6 or Protein S)
    findings: []
  - id: Reactome:R-HSA-481007
    title: Exocytosis of platelet alpha granule contents
    findings: []
  - id: Reactome:R-HSA-8952289
    title: FAM20C phosphorylates FAM20C substrates
    findings: []