> - In ER-positive breast cancer, high nuclear GATA3 was associated with lower distant recurrence (HR 0.60, 95% CI 0.39-0.93); higher/intermediate GATA3 mRNA predicted tamoxifen benefit (HR 0.39, 95% CI 0.24-0.64), whereas low GATA3 showed no clear benefit (HR 0.61, 95% CI 0.31-1.17); after 5 years, low GATA3 showed no further benefit (HR 1.10, 95% CI 0.46-2.61) versus higher GATA3 (HR 0.35, 95% CI 0.19-0.64). (pqac-00000011, pqac-00000012, pqac-00000010, pqac-00000035)
> - In the same cohort, 70% of tumors had high nuclear GATA3; among ER-positive tumors, high nuclear GATA3 was present in 84% versus 19% of ER-negative tumors. (pqac-00000012, pqac-00000013)
> - Cross-tumor pathology data showed GATA3 positivity in all primary and 93% of metastatic urinary carcinomas, and in 94% of primary and 80% of metastatic breast carcinomas, supporting real-world diagnostic use as a nuclear IHC marker. (pqac-00000009)
> - A distal enhancer ~900 kb downstream of GATA3 (hG900/mG900) showed activation strongly correlated with GATA3 levels in human peripheral T cells; the homologous murine region physically looped to the Gata3 transcription start site in Th2 cells and was required for HDM-induced Th2 differentiation and allergic airway inflammation. (pqac-00000021, pqac-00000023, pqac-00000024, pqac-00000034)
> - ILC2-specific tandem GATA3-related super-enhancers (G3SE) were identified as drivers of high GATA3 in late ILC2-committed precursors; G3SE-deficient mice had ILC2 deficiency across bone marrow, lung, liver, and small intestine, and IL17RB+PD-1- late precursors accumulated about 6-fold, indicating a developmental block before ST2+ ILC2 entry. (pqac-00000026, pqac-00000025, pqac-00000027, pqac-00000029)
> - Mechanistically, recent reviews and primary studies converge on GATA3 as a dual-zinc-finger, sequence-specific, pioneer/lineage-defining transcription factor that recognizes GATA/WGATAR motifs and integrates IL-4/STAT6, IL-2/IL-7, TCR, and NOTCH-linked programs with chromatin looping and enhancer activation to establish type-2 immune identity. (pqac-00000033, pqac-00000031, pqac-00000014, pqac-00000020)


*Blockquote: This blockquote condenses the most decision-relevant numbers and mechanisms for human GATA3 across immune biology and pathology. It is useful as a quick reference for prognosis, diagnostic marker performance, and recent enhancer-based mechanistic findings.*