Glial fibrillary acidic protein is a type III intermediate-filament protein that contributes to the cytoplasmic filament network of astrocytes and other GFAP-expressing glial cells. Its self-association and assembly with other intermediate-filament proteins support cytoskeletal organization. Alternative carboxyl termini distinguish alpha, epsilon and kappa splice products with different assembly and interaction properties. A peripheral lysosomal pool regulates chaperone-mediated autophagy in mammalian experimental systems. Pathogenic GFAP variants cause Alexander disease, characterized by astrocytic protein inclusions and nervous-system dysfunction.
Curated functional classes representing distinct biological activities. These may be splice variants, cleavage products, or other forms with different functions.
GFAP_ALPHAGFAP_EPSILONGFAP_KAPPA| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001755 neural crest cell migration | IDA PMID:26571399 A collagen VI-dependent pathogenic mechanism for Hirschsprun... | UNDECIDED | Summary: The specific GFAP-to-migration experiment remains unresolved. Reason: Selected original Results/Methods and the complete supplement concern Col6a4-dependent enteric neural-crest behavior. The inspected glial markers and reagent table do not identify the GFAP experiment underlying this genuine IDA. Preserve its two conjunctive extension atoms; incomplete reconciliation does not establish misattribution. Supporting Evidence: |
| GO:0005178 integrin binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: GFAP associates with an integrin complex in a specialized glial context. Reason: The actual rat donor has direct 16988027 evidence: sciatic-nerve GFAP co-precipitates alpha-v/beta8 integrins, with mouse corroboration. Preserve the human orthology inference and informative partner class; this is not purified contact mapping, a human product-specific assay, or evidence that GFAP is a receptor agonist. |
| GO:0005200 structural constituent of cytoskeleton | IBA GO_REF:0000033 | ACCEPT | Summary: GFAP supplies intermediate-filament structure. Reason: The actual AN0/PTN000580114 assertion is ancestral to human AN268, whose aligned sequence matches canonical GFAP. Independent structural evidence agrees; alternative-tail differences do not negate the gene-level function. |
| GO:0005200 structural constituent of cytoskeleton | IEA GO_REF:0000120 | ACCEPT | Summary: The orthology mapping captures GFAP structural activity. Reason: The orthology mapping agrees with the independently established structural function. GFAP contributes the filament subunit itself; this is not an expression-only phenotype inference. |
| GO:0005200 structural constituent of cytoskeleton | TAS PMID:2740350 Molecular cloning and primary structure of human glial fibri... | ACCEPT | Summary: Cytoskeletal structure is a defining GFAP function. Reason: Retain this established structural function with independent assembly support. PMID2740350 remains abstract-only; no particular uninspected experiment is claimed from that source. |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O00151 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | MODIFY | Summary: Vimentin binding is linked to the structural filament function of GFAP. Reason: Retain cytoskeletal protein binding: the source interaction and independent human GFAP/vimentin filament observations jointly establish an informative structural relationship (PMID:6371809). This does not require a particular heterodimer geometry or binding to an already assembled polymer. The H-I-05 author release supplies the mapped pair; it is not the unrecovered original 2005 supplement or independent clone sequencing. Proposed replacements: cytoskeletal protein binding |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q5T2W1 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: GFAP has a positive screen interaction with KIAA0408. Reason: The author-maintained H-I-05 release positively maps this pair to KIAA0408/Q6ZU52 (GeneID9729), with separate pooled-prey and array pipeline entries. The actual partner record has no FUNCTION or SIMILARITY field establishing a useful functional binding class. Remove the generic term from the functional summary while retaining the positive experimental pair and literal original identifier. Neither lack of a specific class nor the historical identifier is evidence that the experimental interaction is false. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: GFAP has a positive screen interaction with SH3YL1. Reason: The author-maintained H-I-05 release retains the GFAP/SH3YL1 positive Y2H pair. The actual partner record provides an SH3YL1-family similarity statement but no FUNCTION statement that establishes a suitable binding class. The presence of an SH3 domain does not show that GFAP contacts that domain. Remove generic protein binding from the functional summary while preserving the experimental association; do not assert a wrong pair or fabricate domain specificity. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:17500595 Huntingtin interacting proteins are genetic modifiers of neu... | REMOVE | Summary: GFAP interaction with UniProtKB:P42858. Reason: The original table identifies GFAP peptides in human-brain material recovered with an N-terminal huntingtin fragment containing expanded polyglutamine. Preserve that association, including its fragment and peptide-validation limits. The inspected HTT record does not establish a sufficiently specific partner class for refinement; generic binding adds little information and does not establish a direct, full-length wild-type or physiological GFAP–HTT interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:A1A4E9 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O75928 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P00540 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. MOS is a verified kinase and the original pair passed individual retesting; kinase activation or GFAP phosphorylation is not required by the binding-term definition. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P14373 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P19012 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P25791 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P35398 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q08117 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q08379 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q13490 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Preserve the GFAP–ZC2HC1C screen pair without retaining generic protein binding as a function. Reason: S2G supports the interaction. The Q53FD0 record has a curated ZC2HC1-family assignment but no FUNCTION statement establishing a more informative binding-partner class. A zinc-finger name does not establish a DNA-binding transcription factor, and no contact domain or mechanism is mapped. The removal is an annotation-informativeness decision, not rejection of the positive experiment. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Preserve the GFAP–C6orf165/CFAP206 interaction while omitting generic protein binding. Reason: Official Q8IYR0 aliases and GeneID154313 resolve C6orf165 in S2G to CFAP206. Its FUNCTION supports a role in flagellar radial-spoke establishment and ciliary motility, with mixed human experimental and mouse by-similarity attribution. Requirement for assembly alone does not establish that this partner is itself a structural cytoskeletal component for a binding refinement. No GFAP role in sperm flagella or respiratory cilia follows from this pair. The experimental interaction remains positive. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: The GFAP–LGALS14 interaction is retained as evidence but does not yield an informative supported GO refinement here. Reason: The positive S2G pair is secure. Q8TCE9 independently supports LGALS14 carbohydrate-binding activity, but that activity belongs to the partner, not GFAP. The current ontology search did not identify an applicable general galectin/lectin-binding term; the returned RBL-family binding term is specific to a different lectin family. No glycan-mediated contact, GFAP sugar binding or T-cell apoptosis mechanism was demonstrated. Omit generic protein binding without disputing the pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Retain the positive GFAP–PIH1D2 pair outside the functional assertion set. Reason: The independent Q8WWB5 record supplies a PIH1-family classification but no FUNCTION establishing a specific supported binding class. PIH1-domain presence alone does not establish chaperone or enzyme identity, and the screen does not map the GFAP contact domain. Remove uninformative protein binding while preserving the interaction and its original provenance. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Preserve the GFAP–SH3YL1 interaction without a generic protein-binding annotation. Reason: The positive S2G pair is not contradicted. Q96HL8 has a curated SH3YL1-family assignment but no FUNCTION statement sufficient for a class-specific replacement. The partner having an SH3 domain does not show that GFAP binds that domain. No actin-remodeling or membrane-signaling activity is assigned to GFAP from the pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Retain the GFAP–NXF1 interaction but omit the uninformative protein-binding assertion. Reason: S2G supplies a positive interaction with Q9UBU9/NXF1. The independent FUNCTION identifies an mRNA export receptor, but the current GO search did not establish an applicable specific binding-partner term. Nuclear receptor binding refers to ligand-regulated DNA-binding transcription factors and therefore does not describe NXF1. NXF1 RNA binding/export activity cannot be transferred to GFAP, and no GFAP participation in an endogenous export complex was shown. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Preserve the positive GFAP–FAM50B interaction as experimental evidence, without retaining generic protein binding. Reason: The Q9Y247 record has a curated FAM50-family assignment but no FUNCTION establishing an informative class-specific replacement. Neither the family name nor the binary screen establishes a catalytic, transcriptional or RNA-processing activity for GFAP. The annotation is removed for lack of functional specificity; the pair remains positive. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O75928-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming PIAS2-alpha identifier and the gene-level source assignment remain distinct; an exact partner clone is not newly inferred. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P08727 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P13646 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P14373 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P19012 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q08379 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:I6L9F6 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The reported NEFL_1 sequence exactly matches I6L9F6; this identity does not establish GFAP participation in a neurofilament function. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P07196 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The published NEFL_2 sequence verifies only P07196 residues 1–377 and one trailing nucleotide, not the full physical construct. This limitation and the positive pair are retained. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:27229929 Systematic interactome mapping of acute lymphoblastic leukem... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q12824 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O00151 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The PDLIM1 A249V nondisruption score preserves wild-type binding; it does not supply a GFAP functional phenotype. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O00151 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The variant-comparison experiment is retained as interaction evidence; its disruption measurements do not independently establish the biological function of the GFAP–PDLIM1 interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6ZU52. Reason: The original positive wild-type interaction and variant tests identify KIAA0408 by GeneID 9729, independently cross-referenced by Q6ZU52. Its inspected record supplies no established functional partner class for a more informative term. Remove generic binding while preserving the original pair, variant scores and unverified modern-product equivalence. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8TCE9. Reason: The original variant-interaction table retains a positive LGALS14–GFAP wild-type pair. LGALS14 carbohydrate recognition does not establish carbohydrate binding by GFAP, and the pair does not define another specific GFAP activity. Remove the generic label without treating an interaction-disrupting variant as absence of the wild-type pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8WWB5. Reason: The original pairwise screen retains the PIH1D2–GFAP wild-type interaction and distinguishes variant-specific disruption scores. The inspected partner record does not establish a specific class that warrants refinement. Remove the uninformative generic term while preserving the positive pair and its assay limits. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9UBU9. Reason: The original variant table retains the NXF1–GFAP pair. NXF1 is an mRNA-export factor, not a nuclear hormone receptor; neither its RNA-binding function nor nuclear transport follows for GFAP from this interaction. Remove generic binding without rejecting the original positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner A2RUH7. Reason: The retained HuRI rows support the MYBPHL pair. Its independently documented myosin-binding role does not make GFAP a myosin binder or establish a specific regulatory activity for this pair. Remove the uninformative generic term while preserving the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O75928-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P07196 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P07947 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | MODIFY | Summary: Vimentin binding is linked to the structural filament function of GFAP. Reason: Retain cytoskeletal protein binding: the source interaction and independent human GFAP/vimentin filament observations jointly establish an informative structural relationship (PMID:6371809). This does not require a particular heterodimer geometry or binding to an already assembled polymer. Source-specific clone and assay limits remain in the source guide and evidence archive. Proposed replacements: cytoskeletal protein binding |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P08727 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P13646 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P17661 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P19012 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P45984 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner P57075-2. Reason: The UBASH3A pair remains positive. Its curated FUNCTION emphasizes receptor-trafficking regulation and negligible phosphatase activity at neutral pH; a phosphatase-binding refinement would therefore be unsafe. Remove the generic annotation without rejecting the interaction or inferring a mapped SH3-domain contact. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: GFAP interaction with the incoming partner Q05BL1. Reason: The incoming Q05BL1 record names TP53BP2, while the retained positive HuRI source uses Q13625-2/ORF55351. The inspected Q05BL1 record lacks an independent accession-to-source-clone crosswalk. Preserve the original assertion pending that identity reconciliation; this is not a negative interaction or a claim that TP53BP2 was absent from the screen. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q08379 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The stable GOLGA2 gene crosswalk is supported, while historical clone sequence and natural-product equivalence remain unresolved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q15323 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q16543. Reason: The CDC37 interaction is retained. Curated FUNCTION identifies a kinase-recruiting Hsp90 co-chaperone; this does not by itself establish that CDC37 is the protein-folding chaperone class targeted by GO:0051087, or that GFAP is a folding client. Remove generic binding without reversing the positive assay or transferring CDC37 kinase-binding activity to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q2TAC2-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q2TBE0. Reason: The CWF19L2 pair is retained as positive. Its RNA-binding and spliceosomal roles do not establish GFAP RNA binding, RNA catalysis or a particular spliceosome-regulatory activity. The generic binding label contributes no supported molecular specificity. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q6A163 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q6NX45. Reason: The ZNF774 pair remains positive. A C2H2-family assignment and tentative transcriptional-regulation statement do not independently establish the DNA-binding RNA polymerase II transcription-factor class. Remove generic binding without manufacturing that refinement or denying the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q6NYC8. Reason: The PPP1R18 pair is positive. The partner is described as a possible targeting regulator of phosphatase 1, not the catalytic phosphatase itself. No GFAP phosphatase-binding activity or measured cytoskeletal-regulatory mechanism follows from the generic pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q7L775. Reason: The EPM2AIP1 pair is retained. Its name as a laforin-interacting protein does not make it an enzyme or establish a molecular function performed by GFAP. Remove the uninformative generic label without disputing the source interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q7Z3Y8 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8IYX1 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q8N720. Reason: The ZNF655 pair is positive, but its inspected FUNCTION calls it a probable transcription factor and does not establish the specific DNA-binding RNA polymerase II partner class. Remove the generic binding term without treating the interaction as false. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8NI38 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q8TCE9. Reason: The LGALS14 pair is positive. The partner is a carbohydrate-binding lectin, but that function cannot be transferred to GFAP from a protein interaction. No more specific GFAP activity is established here, so remove the generic label while retaining the named pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q8WUE5. Reason: The CT55 pair is retained. Its reported spermatogenesis/autophagy context does not define a molecular partner class that establishes a more specific GFAP activity. Remove generic binding without inferring GFAP participation in those processes. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q96BZ8. Reason: The LENG1 pair is positive, but the inspected independent record supplies no established molecular partner role supporting a specific refinement. Remove the uninformative label; neither the interaction nor the existence of uncharacterized LENG1 biology is rejected. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96HA8 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96T49 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9BWT7 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9H0I2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | UNDECIDED | Summary: GFAP interaction with the incoming partner Q9HC98-4. Reason: The retained positive HuRI source names Q9HC98-1/ORF3567, whereas this incoming assertion names Q9HC98-4. NEK6 is independently established as a protein kinase, but that gene-level class does not reconcile these different product identifiers. Preserve the positive gene-level interaction and both literal suffixes while leaving the product-specific assertion undecided pending source-to-product reconciliation; no GFAP phosphorylation or isoform exclusivity is inferred. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q9NU19. Reason: The TBC1D22B pair is positive. Its inspected FUNCTION only tentatively assigns Rab GTPase-activating activity, without an identified donor source; that is insufficient for a confident partner-class refinement here. Remove generic binding without denying the interaction or transferring a putative GAP activity to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9NYB9-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q9UBB9. Reason: The TFIP11 pair is positive. The partner assists spliceosome disassembly, but this does not establish GFAP splicing catalysis or a specific binding activity beyond the named interaction. Remove the generic term without contradicting the source assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: GFAP interaction with the incoming partner Q9UBU9. Reason: The NXF1 pair is positive. NXF1 is an mRNA-export factor, not a nuclear hormone receptor; its RNA binding and transport roles do not transfer to GFAP. Remove generic binding while preserving the source pair and its product-mapping limits. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:A0A1B0GWI1. Reason: The original positive NCRNA00238 pair is reconciled to CCDC196 by the official HGNC historical-symbol record. Its inspected protein record supplies no established functional class supporting a specific binding refinement. Remove the generic label without rejecting the positive pair or claiming full clone/product equivalence. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:A2RUH7. Reason: The MYBPHL pair is positive. Its independently documented myosin-binding activity does not mean that GFAP binds myosin, and the pair does not establish a particular GFAP regulatory function. Remove generic binding while retaining the named interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:A4FUJ8 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The MKL1/MRTFA gene-identifier crosswalk and independently curated coactivator classification remain valid; neither is a GFAP functional assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O00124. Reason: The UBXN8 pair is positive. Its ERAD-associated VCP-tethering role does not make UBXN8 the ATPase, nor does it establish GFAP involvement in degradation or a mapped interaction domain. Remove the generic term without disputing the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O15273 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O15287. Reason: The FANCG pair remains positive. Its DNA-repair and checkpoint roles do not independently establish a catalytic partner or a specific activity performed by GFAP. Remove the generic binding label without transferring DNA repair or rejecting the source interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O15534 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O15535. Reason: The ZSCAN9 pair is retained. The inspected FUNCTION only tentatively assigns transcriptional regulation; zinc-finger family membership alone does not establish the specific DNA-binding RNA polymerase II transcription-factor class. Remove generic binding without denying the positive assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O43809. Reason: The NUDT21 pair is positive. Its RNA-processing and nucleotide-binding roles do not establish GFAP RNA binding; the curated record explicitly distinguishes nucleotide binding from hydrolysis, so a Nudix-family name is insufficient for enzyme-binding refinement. Remove the generic label while preserving the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O60304. Reason: The ZNF500 pair remains positive. Its tentative transcriptional-regulation statement and C2H2-family assignment do not independently establish a specific transcription-factor partner class. Remove generic binding without rejecting the assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O60784-2. Reason: The TOM1 pair is positive. TOM1 is independently characterized as a trafficking adapter, but this pair does not map a domain or show GFAP recruitment to a signaling scaffold, myosin or cargo. Remove generic binding without transferring TOM1's ubiquitin, lipid or trafficking functions to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O75934. Reason: The BCAS2 pair is positive. Its spliceosomal role and possible spliceosome-assembly scaffold activity do not establish a signaling-scaffold partner as defined by the inspected binding term. Remove the generic label without assigning splicing catalysis or rejecting the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O76024. Reason: The WFS1 pair is positive. WFS1 regulation of calcium homeostasis and V-ATPase-subunit stability does not make it the ATPase or establish a specific GFAP binding activity. Remove generic binding while preserving the named interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O76041 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:O94851 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:O95391. Reason: The SLU7 pair is positive. Its exon-positioning role during the spliceosome's second reaction does not by itself make SLU7 a catalytic enzyme or assign a specific molecular function to GFAP. Remove generic binding without rejecting the interaction or transferring splicing participation. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P00352 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P00491 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P06241-3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P07196 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | MODIFY | Summary: Vimentin binding is linked to the structural filament function of GFAP. Reason: Retain cytoskeletal protein binding: the source interaction and independent human GFAP/vimentin filament observations jointly establish an informative structural relationship (PMID:6371809). This does not require a particular heterodimer geometry or binding to an already assembled polymer. Source-specific clone and assay limits remain in the source guide and evidence archive. Proposed replacements: cytoskeletal protein binding |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P08727 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:P10073. Reason: The ZSCAN22 pair is positive. The inspected record provides a tentative transcriptional-regulation statement and zinc-finger family assignment, insufficient for a specific DNA-binding transcription-factor refinement. Remove generic binding without rejecting the pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P10599 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P16284 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | UNDECIDED | Summary: GFAP interaction with UniProtKB:P17023. Reason: Positive interaction records are retained, but the accession-to-gene mapping conflicts: incoming P17023 is ZNF19/GeneID7567, whereas the associated IntAct records carry GeneID6155/RPL27, matching the original table. Leave this source-specific assertion undecided until the identity conflict is reconciled; neither a negative assay nor an established wrong-gene correction is asserted. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:P17024. Reason: The ZNF20 pair is positive. Its tentative transcriptional-regulation statement and C2H2-family assignment do not independently establish the DNA-binding RNA polymerase II transcription-factor class. Remove generic binding without denying the named interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P17661 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P20339 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:P21281. Reason: The ATP6V1B2 pair remains positive. The independent record explicitly identifies a non-catalytic V-ATPase subunit; binding this subunit alone does not establish binding to the catalytic ATPase or an assembled proton pump. Remove generic binding without rejecting the association or assigning acidification to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P24863 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P27986-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P29466-3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P35222 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P35638 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:P42858. Reason: The huntingtin pair is retained as positive. The inspected HTT FUNCTION and interaction record does not establish a sufficiently specific partner class for refinement here; its trafficking and proteostasis associations do not transfer to GFAP. Remove generic binding without rejecting the source interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:P50749. Reason: The RASSF2 pair is positive. KRAS-effector activity and stabilization of STK3 do not make the partner a GTPase or kinase, nor do they establish a specific GFAP regulatory activity. Remove generic binding while preserving the named pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P57729 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P58304 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. VSX2 is a verified DNA-binding transcription factor; its identity and positive pair do not themselves supply an informative GFAP function. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P61978 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:P63010-2. Reason: AP2B1 is a clathrin-adaptor subunit and an endocytic accessory-protein platform. That does not establish a signaling-scaffold class, binding to the complete AP-2 complex or a mapped appendage contact in this pair. Remove generic binding while retaining the positive interaction and original product identifier. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q06481-5. Reason: The inspected APLP2 record describes protease-inhibitory and other context-dependent functions, but these do not establish a specific GFAP activity or their applicability to incoming product Q06481-5. Remove generic binding without rejecting the positive pair or transferring protease inhibition to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q12824 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q12891 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q12986 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q13216-2. Reason: ERCC8 is the substrate-recognition component of a cullin ubiquitin-ligase complex, not independently the catalytic ligase. This pair does not establish a specific GFAP activity or repair function. Remove generic binding while preserving the interaction and incoming ERCC8 product. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q13322-4 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q13387-4 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q13573 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q13829 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q14005-2. Reason: IL16 has distinct precursor-associated intracellular and processed cytokine roles. The gene-level pair does not resolve which functional region of incoming product Q14005-2 mediates binding; a cytokine- or scaffold-binding refinement would overstate that scope. Remove generic binding while preserving the positive pair and product uncertainty. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q14525 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q14689-3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q14693 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q14694 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q14847-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q15049. Reason: MLC1 regulates astrocyte osmotic responses and may regulate membrane protein complexes; the inspected record does not establish it as a catalytic or ion-channel partner class. Remove generic binding without rejecting the pair or assigning calcium transport to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q16549 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q1L5Z9. Reason: The inspected LONRF2 record supplies no established catalytic activity supporting refinement; a RING-containing name alone does not prove ubiquitin-ligase activity. Remove generic binding while retaining the positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q2TBE0. Reason: CWF19L2 participates in RNA binding and spliceosome stability, and is required for lariat debranching. Necessity in that reaction does not establish it as the catalytic enzyme or give GFAP a specific splicing function. Remove the generic label without denying the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q3SX64. Reason: The inspected CIMAP1D record has a family assignment but no established molecular partner role supporting a specific refinement. Remove generic binding while retaining the positive interaction; the protein name alone is not evidence of GFAP microtubule binding. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q53FD0-2. Reason: The inspected ZC2HC1C record supplies a family assignment but no established functional class that supports a narrower binding term. Remove generic binding without rejecting the pair or inventing a zinc-finger-dependent transcriptional role. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q53R41. Reason: FASTKD1 independently regulates mitochondrial RNA levels; the FAST-kinase family name does not establish catalytic protein-kinase activity. Remove generic binding while preserving the interaction and avoiding transfer of mitochondrial RNA regulation to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q5SZD1. Reason: The inspected C6orf141 record supplies no established partner function that supports a specific binding refinement. Remove the uninformative generic label while retaining the named positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q5T2W1 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q5T5P2-6. Reason: KIAA1217 is implicated in intervertebral-disk development by similarity, but that process requirement does not establish a specific molecular partner class. Remove generic binding without assigning skeletal development to GFAP or denying the positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q5T6S3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q5TDH0-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q5VWN6 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q5VYS8-5 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6DKI2. Reason: LGALS9C has a by-similarity galactoside-binding function. A protein interaction does not transfer carbohydrate binding to GFAP, and no specific alternative activity is established. Remove generic binding while retaining the positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q6GQQ9-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6H8Q1-8. Reason: ABLIM2 has an experimentally supported F-actin/ABRA association, while its scaffold and ABRA-stimulatory roles remain tentative in the inspected record. These do not establish direct GFAP-actin binding or a sufficiently defined signaling-scaffold refinement for this pair. Remove generic binding without rejecting the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6N069-4. Reason: NAA16 is an auxiliary NatA subunit, rather than independently the acetyltransferase catalyst. Remove generic binding without treating association with this subunit as GFAP acetyltransferase binding or assigning acetylation to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6NX45. Reason: The ZNF774 record only tentatively assigns transcriptional regulation by similarity. Its zinc-finger family does not independently establish the specific DNA-binding RNA polymerase II transcription-factor class. Remove generic binding while preserving the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q6P1J6-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6UXG2-3. Reason: ELAPOR1 has proposed cell-death and autophagy roles, but these phenotypes and its HSPA5 interaction do not establish a specific GFAP binding function or make ELAPOR1 a folding chaperone. Remove generic binding without disputing the pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6X4W1-6. Reason: NSMF couples neuronal signaling to nuclear responses; the inspected record does not establish a defined catalytic, transcription-factor or signaling-scaffold class for a narrower binding assertion. Remove generic binding without transferring neuronal migration or transcriptional regulation to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6ZMI0-5. Reason: PPP1R21 is a binding hub of the FERRY RNA-transport complex and a putative phosphatase regulator. It is not the phosphatase, and a transport-complex hub does not automatically satisfy the signaling-scaffold definition. Remove generic binding while preserving the pair and original product identifier. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6ZNE9. Reason: RUFY4 is a motor/endomembrane adapter that links ARL8 to dynein-dynactin. That does not establish GFAP binding to the motor, a GTPase or microtubule polymers, nor a mapped scaffold interface. Remove generic binding while retaining the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q6ZU52. Reason: The inspected KIAA0408 record provides no established molecular partner class supporting a specific refinement. Remove the uninformative generic label while preserving the positive pair and its historical gene crosswalk. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q71DI3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. H3.2 identity is independently secure; no artifact or requirement for GFAP chromatin regulation is asserted. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q7KZS0 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q7Z3I7. Reason: ZNF572 has only tentative by-similarity transcriptional regulation in the inspected record. Its zinc-finger family does not establish the specific DNA-binding RNA polymerase II transcription-factor class. Remove generic binding while retaining the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q7Z698 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q7Z699 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q86V28. Reason: Q86V28 has a non-ARBA PIRNR adaptor-complex large-subunit family assignment, but that does not establish a specific signaling-scaffold class or contact with a whole adaptor complex. Remove generic binding while retaining this accession and the positive source pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q86VK4-3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q86WT6-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8IUI8. Reason: CRLF3 has a tentative role in cell-cycle regulation, but the receptor-like name does not establish a verified receptor or catalytic class. Remove generic binding without denying the pair or assigning cell-cycle effects to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8IUW3. Reason: The SPATA2L record supplies a family assignment without an established catalytic or scaffold function. Do not transfer SPATA2-paralog roles by name. Remove generic binding while preserving the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8IY31-2. Reason: IFT20 is a transport-complex subunit with ciliary trafficking and receptor-stability roles. The inspected evidence does not make it a catalytic enzyme, folding chaperone or a component of cytoskeletal polymers. Remove the generic label without denying its interaction or assigning ciliary transport to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8IYX7 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8N0Y2-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8N488 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8N6F8. Reason: METTL27 is only a probable methyltransferase inferred from an ortholog in the inspected record. Preserve that uncertainty rather than upgrade the name to established enzymatic activity. Remove generic binding without rejecting the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8N6K7-2. Reason: No established functional partner class is supplied by the inspected SAMD3 record. Remove the uninformative generic binding label while retaining the named positive pair and incoming product -2. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8N6T3-3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The ARFGAP1 GAP class, rat-ortholog evidence and position of the incoming -3 edit outside the Arf-GAP domain remain recorded. They characterize the partner, not a GFAP functional role. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8N7T0. Reason: The retained IntAct crosswalk explicitly links Q8N7T0 to GeneID349152/DPY19L2P2 in the positive source pair; this is not independent sequence equivalence. The inspected protein record supplies no established partner activity for a specific refinement. Remove the generic label without rejecting the assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8NA54 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8NDH6-2. Reason: The inspected ICA1L record provides no established partner activity supporting a specific binding refinement. Remove the generic label while retaining the positive pair, incoming -2 product and its unresolved historical clone equivalence. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8NHQ8-2. Reason: The inspected RASSF8 record provides no established specific partner function. A Ras-association family name does not prove GTPase catalysis or a signaling-scaffold role. Remove generic binding without rejecting the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8NHS9. Reason: SPATA22 is required for meiotic recombination by ortholog evidence; necessity does not establish a catalytic enzyme or a specific GFAP function. Remove generic binding while preserving the positive pair and avoiding a GFAP meiosis assertion. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8TBB1 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8TBE0 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8TCX5. Reason: RHPN1 has no enzymatic activity in its ortholog-based FUNCTION, and its proposed Rho-to-cytoskeleton relay remains tentative. Remove generic binding without inferring GFAP binding to Rho itself or a proven cytoskeletal regulatory activity from the partner name. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | UNDECIDED | Summary: GFAP interaction with UniProtKB:Q8WUW1. Reason: Positive IntAct records attach incoming Q8WUW1/BRK1 to GeneID7428/VHL, whereas the current BRK1 record has a different gene identity. The retained original table and positive records therefore do not settle the accession-to-assay join. Preserve both identities and the positive assay without applying BRK1 cytoskeletal-class refinement until this conflict is reconciled. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8WW38 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q8WWW0-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q8WXH2. Reason: JPH3 structurally supports junctional membrane coupling, but the inspected record does not establish the specific multi-partner signaling-scaffold class for this pair. Remove generic binding without inferring GFAP binding to calcium channels, membrane tethers or an assembled junction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q92613. Reason: JADE3 is a scaffold subunit of an HBO1 histone-acetyltransferase complex, rather than its catalytic acetyltransferase. That use of scaffold does not automatically satisfy signaling-scaffold binding. Remove generic binding without asserting GFAP acetyltransferase binding or chromatin modification. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q92782-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96A32 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96B77. Reason: TMEM186 is required for mitochondrial complex-I assembly as an MCIA component; this does not make it the respiratory enzyme or a demonstrated folding chaperone. Remove generic binding without assigning GFAP oxidative phosphorylation or mitochondrial localization. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96DF8. Reason: ESS2 has a tentative ortholog-inferred splicing role but no established narrower binding-partner class in the inspected record. Remove generic binding while retaining the positive pair and avoiding a GFAP splicing assertion. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96DI7. Reason: SNRNP40 is a structural spliceosomal subunit required for splicing, not independently its catalyst. Remove generic binding without asserting GFAP binding to an assembled spliceosome, splicing activity or a catalytic enzyme. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96EY1-3. Reason: DNAJA3 has product-dependent signaling and apoptosis effects and an HSPA9 interaction, but these statements do not themselves establish the folding-chaperone class targeted by chaperone binding. Remove generic binding without denying the pair or inferring a role for incoming product -3 from results on products 1 and 2. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96EZ8 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96FT7-4. Reason: ASIC4 does not show measurable stand-alone pH-gated channel activity in the ortholog-based record; heteromeric or alternative gating remains possible. Remove generic binding without promoting those possibilities into a demonstrated channel-binding refinement or denying the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96FW1 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96FX8. Reason: PERP supports desmosome assembly and epithelial adhesion, predominantly by ortholog evidence. This does not independently establish direct adhesion-molecule binding, a signaling-scaffold class or a specific GFAP activity. Remove generic binding without rejecting the positive pair or assigning skin-barrier functions to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96GM5 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96HB5 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96HC4 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96I34. Reason: PPP1R16A independently inhibits PP1, but it is the regulatory protein rather than the phosphatase. Remove generic binding without transferring its partner identity to a GFAP-phosphatase interaction or assigning phosphatase inhibition to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96MN9-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96PV4. Reason: The inspected PNMA5 record supplies a family assignment without an established specific molecular function. Remove generic binding while retaining the positive interaction; a neuronal or antigen-related name is not a partner-class assay. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q96PV6. Reason: The inspected LENG8 record provides no established partner function supporting a specific binding refinement. Remove the uninformative generic label without rejecting the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q96QF0-7 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q99457. Reason: NAP1L3 is curated as a histone chaperone by similarity. Histone handling does not by itself establish the nascent-or-unfolded-protein folding-chaperone class, and this pair does not show GFAP binding to histones. Remove generic binding while retaining the interaction and the independent histone-chaperone role. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q99598 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9BR01-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9BRR0 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9BRX9 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9BVG8-5 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9BX40-2. Reason: LSM14B is an ortholog-supported RNA-binding and mRNA-storage regulator. Binding to that protein does not confer RNA binding, translation or reproductive functions on GFAP, and no narrower informative partner class is established here. Preserve the positive pair while removing the generic label. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9BY12-3. Reason: SCAPER regulates the CCNA2-CDK2 complex and transiently retains cyclin A2 in the cytoplasm. It is neither the cyclin nor the kinase. Remove generic binding without inferring GFAP binding to those separate partners or cell-cycle regulation. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9C0F3. Reason: ZNF436 has tentative transcriptional repression in the inspected record, without an independently established sequence-specific DNA-binding or coregulator partner role. Remove generic binding while preserving the interaction and its experimental source. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9GZS3 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9H4I2-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9H7C4 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9NR11-2. Reason: ZNF302 has only a tentative, untagged transcriptional-regulation statement and a zinc-finger family assignment. These do not establish the specific DNA-binding RNA polymerase II transcription-factor class. Remove generic binding without rejecting the positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9NRP7 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9NS23-4. Reason: RASSF1 has strongly product-dependent signaling roles; its record explicitly distinguishes functional isoform A from isoform C with no identified function. The gene-level pair does not resolve a specific scaffold role for incoming -4. Remove generic binding without transferring activities from another product or rejecting the interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9NVV9 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9NYB9-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming partner is ABI2-2. Its actin-regulatory class is valid, but no new GFAP function is established by the inspected pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9NZC7-5. Reason: WWOX is only a putative oxidoreductase in the inspected record. Its signaling and disease-associated roles do not establish catalytic activity or a sufficiently specific scaffold class for incoming -5. Remove generic binding without denying the interaction or transferring apoptosis to GFAP. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9P0T4. Reason: ZNF581 has only a tentative, untagged transcriptional-regulation statement. Do not infer a DNA-binding RNA polymerase II transcription-factor class from its name. Remove generic binding while retaining the positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9UBQ6 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9UBU7. Reason: DBF4A is the activating regulatory subunit of CDC7, not itself the protein kinase. Remove generic binding without assigning GFAP a CDC7 interaction, phosphorylation activity or DNA-replication function. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9UJX2. Reason: CDC23 is a noncatalytic APC/C component; the complex-level ubiquitin-ligase description does not establish ligase activity for this subunit. Remove generic binding without claiming GFAP binding to the complete catalytic complex or a cell-cycle role. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9UM82 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9UNY5. Reason: ZNF232 has a tentative, untagged transcriptional-regulation statement and a zinc-finger family assignment. Neither establishes the specific DNA-binding transcription-factor class. Remove generic binding while preserving the positive interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9UQB8-6 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9Y239 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9Y261-2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9Y2L8. Reason: ZKSCAN5 has only a tentative, untagged transcriptional-regulation statement and family classification. Remove generic binding without promoting that uncertainty into an established DNA-binding RNA polymerase II transcription-factor class or denying the positive pair. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9Y2M5 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9Y3D2 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9Y446 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9Y483-4 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The incoming product identifier and the previously documented clone-equivalence limits remain preserved. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: GFAP interaction with UniProtKB:Q9Y575-3. Reason: ASB3 is a substrate-recognition component of an E3-ligase complex, rather than independently its catalytic ligase. Remove generic binding without inferring GFAP ligase binding or ubiquitination from this regulatory-subunit interaction; preserve incoming ASB3-3 and its unresolved historical-clone equivalence. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P07196 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The NEFL AP-MS association is preserved without treating co-purification as direct contact or importing a GFAP–NEFL filament function from vimentin. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MODIFY | Summary: Vimentin binding is linked to the structural filament function of GFAP. Reason: Retain cytoskeletal protein binding: the source interaction and independent human GFAP/vimentin filament observations jointly establish an informative structural relationship (PMID:6371809). This does not require a particular heterodimer geometry or binding to an already assembled polymer. BioPlex alone establishes co-purification; the binary sources PMID:16189514, PMID:32296183 and PMID:32814053 independently support the pair. Its historical P14136-2 label is not equated to a modern natural product. Proposed replacements: cytoskeletal protein binding |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P17661 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The AP-MS association with desmin does not by itself resolve direct binding or a functional GFAP–desmin filament relationship. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P52747 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The BioPlex result is cellular co-purification; the shared MuSIC dataset is not independent functional confirmation. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:Q9H7C4 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. Syncoilin is an atypical intermediate-filament-family protein; its class does not demonstrate GFAP–syncoilin coassembly, and AP-MS does not resolve direct contact. Supporting Evidence: |
| GO:0005515 protein binding | IPI PMID:34819669 A multi-scale map of cell structure fusing protein images an... | REMOVE | Summary: The generic interaction annotation is not functionally informative for GFAP. Reason: The independent partner classification for UniProtKB:P52747 remains valid, but the inspected interaction evidence does not establish a useful GFAP molecular function beyond the named association. Remove generic protein binding for lack of functional information, without rejecting the reported interaction. The MuSIC AP-MS edge also entered BioPlex3. Reciprocal table layouts and the second citation are not independent functional validation. Supporting Evidence: |
| GO:0005737 cytoplasm | EXP PMID:12058025 A new splice variant of glial fibrillary acidic protein, GFA... | TOO GENERAL | Summary: The experimental cytoplasmic location is supported but nonspecific. Reason: The experimental localization is supported. Cytoplasm is redundant with the retained cytosol descendant and specific filament locations; the action concerns informativeness, not rejection of the experiment. Supporting Evidence: |
| GO:0005737 cytoplasm | IDA PMID:12355421 Cellular localization of cyclooxygenase-1 and cyclooxygenase... | TOO GENERAL | Summary: The retained cytoplasm assertion is a redundant broad location. Reason: The source-specific GFAP image remains inaccessible, but the same location is independently supported. Preserve the IDA while marking this broad ancestor of retained cytosol as uninformative; no misattribution is inferred. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | TOO GENERAL | Summary: Cytoplasm is true but adds little to retained specific locations. Reason: The combined mapping is biologically sound. Current GO explicitly places retained cytosol GO:0005829 part_of cytoplasm; specialized lysosomal-surface localization is also retained. This broad compartment adds no distinct localization claim, rather than being an incorrect electronic annotation. Supporting Evidence: GO_REF:0000120 |
| GO:0005764 lysosome | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: A specialized GFAP pool associates with lysosomes. Reason: Preserve the sheep-derived ISS and colocalizes_with qualifier. The specialized peripheral lysosomal pool is distinct from the principal filament pool; primary species limits are documented in the source guide. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1253321 | KEEP AS NON CORE | Summary: Reactome places the GFAP protein product in the cytosol. Reason: The actual event1253321 output is entity1253311, explicitly human P14136 chain1–432 in cytosol. Retain this soluble-compartment representation alongside filament localization. The event models regulation of GFAP expression by ERBB4/TAB2/NCOR1; it does not make GFAP itself a transcriptional repressor. Supporting Evidence: Reactome:R-HSA-1253321 |
| GO:0005856 cytoskeleton | IEA GO_REF:0000107 | TOO GENERAL | Summary: Cytoskeleton is a supported parent of the precise filament location. Reason: The mouse-based mapping is consistent with GFAP biology. Current GO places intermediate filament and intermediate-filament cytoskeleton below cytoskeleton; those retained annotations capture the structural compartment more usefully. This is breadth reduction, not evidence of evolutionary loss. Supporting Evidence: GO_REF:0000107 |
| GO:0005882 intermediate filament | IBA GO_REF:0000033 | ACCEPT | Summary: GFAP acts within intermediate filaments. Reason: The actual AN0/PTN000580114 component assertion lies on the matched human lineage. Preserve is_active_in and all donor identities; this does not claim equal assembly competence for every product. |
| GO:0005882 intermediate filament | IEA GO_REF:0000120 | ACCEPT | Summary: GFAP is an intermediate-filament constituent. Reason: The mouse/InterPro mapping agrees with the independently established filament role. This specific structural compartment is informative beyond generic cytoplasmic localization. |
| GO:0005882 intermediate filament | TAS PMID:2740350 Molecular cloning and primary structure of human glial fibri... | ACCEPT | Summary: The historical filament location remains well supported. Reason: The historical TAS agrees with independent filament evidence. Preserve its source and the abstract-only access limit without inventing a particular experiment from the inaccessible original. |
| GO:0016020 membrane | IEA GO_REF:0000107 | TOO GENERAL | Summary: Generic membrane association is superseded by a specific peripheral location. Reason: The retained cytoplasmic side of lysosomal membrane is a verified descendant of membrane. Prefer that informative location. Peripheral association satisfies membrane localization; absence of a transmembrane segment is not grounds for rejection. |
| GO:0019900 kinase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: GFAP associates with nucleoside diphosphate kinases. Reason: The rat donor IPI traces to 11082283. Its authentic abstract explicitly reports both Nm23 isoforms associated with GFAP in differentiated rat C6 cells. These are phosphate-transfer enzymes, fitting the current kinase-binding definition. Retain this contextual association without assigning their catalytic activity to GFAP or claiming uninspected full-text details. |
| GO:0042802 identical protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | ACCEPT | Summary: GFAP self-association supports its filament-forming structural role. Reason: The original HI-II-14 S2G row1917 reports the GFAP self pair. The library ORF2920 sequence equals canonical P14136-1, although S2G is gene-level. The study explicitly retested homomeric pairs; retain identical-protein binding without inferring a particular physiological stoichiometry or an isoform-exclusive function. Supporting Evidence: |
| GO:0042802 identical protein binding | IPI PMID:25910212 Widespread macromolecular interaction perturbations in human... | ACCEPT | Summary: A defined canonical GFAP clone has a positive self-interaction. Reason: Original S3A row1013 reports the wild-type GFAP self pair, and the retained WT CDS translates exactly to P14136-1. This directly supports the homotypic association relevant to filament assembly. No GFAP GPCA row was found in the inspected S3B; the validated Y2H positive does not require an invented orthogonal result. Supporting Evidence: |
| GO:0042802 identical protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | ACCEPT | Summary: The HuRI source independently records GFAP self-association. Reason: Three literal assay-projection rows contain P14136-1/ORF2920 on both sides, with screens1 and3. They support the same homotypic structural interaction, not three independent physiological validations. The current product cross-reference matches the source designation; a full experimental clone-sequence comparison was not available for this dataset. Supporting Evidence: |
| GO:0043254 regulation of protein-containing complex assembly | TAS PMID:20176123 Chaperone-mediated autophagy: molecular mechanisms and physi... | MODIFY | Summary: GFAP stabilizes the lysosomal translocation complex against disassembly. Reason: Measured stabilization against Hsc70-driven disassembly supports GO:0043242 more precisely. This is a lateral mechanism refinement, not an ontology descendant. Preserve the original source and part_of CMA atom; initial assembly can occur without GFAP. Proposed replacements: negative regulation of protein-containing complex disassembly |
| GO:0044297 cell body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: GFAP networks occupy the glial cell body. Reason: The exact mouse donor carries multiple experimental cell-body annotations. This spatial context complements projection and end-foot locations and is consistent with the established cytoplasmic filament network. Retain the orthology inference without claiming those donor images were reanalyzed or assigning the location to every GFAP-positive cell state. Supporting Evidence: GO_REF:0000107 |
| GO:0045109 intermediate filament organization | IBA GO_REF:0000033 | ACCEPT | Summary: GFAP contributes to intermediate-filament organization. Reason: The actual AN0/PTN000580114 IBD is on the human lineage. Target experimental evidence legitimately supports the ancestral assertion; self-evidence is not circular. Alternative-tail effects do not negate the conserved structural process. |
| GO:0045109 intermediate filament organization | IDA PMID:15732097 Glial fibrillary acidic protein mutations in infantile, juve... | ACCEPT | Summary: Intermediate-filament organization is independently established for human GFAP. Reason: Retain the curator assertion using independent human assembly evidence. The PMID15732097 experiment remains inaccessible beyond its variant-cohort abstract; this neither establishes an absent assay nor a citation error. |
| GO:0045111 intermediate filament cytoskeleton | IDA GO_REF:0000052 | ACCEPT | Summary: GFAP localizes to the intermediate-filament network. Reason: Retain the HPA localization and its original method reference. Network location is useful alongside filament membership; no independent HPA image reanalysis is claimed. |
| GO:0045111 intermediate filament cytoskeleton | IEA GO_REF:0000117 | ACCEPT | Summary: The ARBA annotation captures the GFAP filament network. Reason: The network location agrees with independent evidence and the HPA record. Preserve the ARBA rule identity; no complete rule-condition reconstruction or redundancy with filament membership is claimed. |
| GO:0045471 response to ethanol | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: Ethanol-associated GFAP expression is insufficient to define a response function. Reason: The rat donor is IEP from 32057593, whose authentic abstract reports increased Gfap mRNA after adolescent ethanol exposure. The response term includes gene-expression changes at the cellular level, but induction of this structural marker does not establish that GFAP protein executes the ethanol response. The human electronic process assignment is therefore overstated; this does not deny the measured expression response or claim the whole inaccessible paper contains no other findings. |
| GO:0048484 enteric nervous system development | IDA PMID:26571399 A collagen VI-dependent pathogenic mechanism for Hirschsprun... | UNDECIDED | Summary: The enteric-development annotation requires an exact GFAP evidence link. Reason: The inspected original and supplement establish enteric-development experiments, but their GFAP-specific basis remains unresolved. Preserve the human IDA and source identity; the distinct Col6a4 perturbation and glial-marker data neither verify this GFAP claim nor justify declaring it erroneous. Supporting Evidence: |
| GO:0060252 positive regulation of glial cell proliferation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: GFAP can support proliferation in a glial injury-model context. Reason: The rat IMP donor traces to 21250919. Its authentic abstract distinguishes separate GFAP-siRNA experiments that suppress C6-cell proliferation from combined GFAP/vimentin treatment in injured rat spinal cord. Retain a contextual regulatory role, without presenting the combined injury outcome as a GFAP-only human assay or a general proliferation mechanism. |
| GO:0097386 glial cell projection | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: GFAP networks extend through glial processes. Reason: The actual mouse donor has an experimental glial-projection assertion. This is a useful cell-architecture context for a glial filament protein, broader than the separately retained astrocyte end-foot. It does not establish uniform occupancy of every fine process or an independent projection-growth activity. Supporting Evidence: GO_REF:0000107 |
| GO:0097449 astrocyte projection | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Astrocyte projections are a characteristic GFAP network context. Reason: The combined mapping retains mouse and rat experimental lineage support. Keep this cell-specific distribution alongside cell body and end-foot locations; it is not a claim that GFAP marks every astrocytic protrusion or that localization alone proves control of projection growth. Supporting Evidence: GO_REF:0000120 |
| GO:0097450 astrocyte end-foot | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: GFAP can occupy astrocyte end-feet. Reason: The mouse donor has the specific experimental end-foot annotation. The current term describes terminal astrocytic processes abutting non-neuronal surfaces, a specialized location consistent with the glial filament network. Preserve the inferred human location without treating it as a direct human ultrastructural assay. Supporting Evidence: GO_REF:0000107 |
| GO:0098574 cytoplasmic side of lysosomal membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: A peripheral GFAP pool occupies the cytoplasmic lysosomal surface. Reason: Retain the rat-derived peripheral lysosomal-surface location. The source guide records the primary sidedness evidence; neither membrane insertion nor a human sidedness experiment is inferred. |
| GO:1904714 regulation of chaperone-mediated autophagy | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: The GFAP lineage inherits a contextual autophagy-regulatory role. Reason: The actual AN260/PTN002902052 IBD and exact rat, mouse and pig descendant set support inheritance on the human lineage. Retain this specialized role; donor count is not a confidence vote. |
| GO:1904714 regulation of chaperone-mediated autophagy | IEA GO_REF:0000120 | KEEP AS NON CORE | Summary: Mouse and rat evidence supports the autophagy-regulatory transfer. Reason: Both named orthologs retain experimental annotations. Preserve gene-level transfer and the opposing effects of different GFAP pools; do not impose a universal regulatory direction. |
| GO:1904714 regulation of chaperone-mediated autophagy | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: GFAP can regulate chaperone-mediated autophagy. Reason: Retain the contextual sheep-donor transfer. The purified-reagent species remains unresolved in the inspected primary text; mammalian regulatory evidence is described in the source guide. |
| GO:1904714 regulation of chaperone-mediated autophagy | TAS PMID:20176123 Chaperone-mediated autophagy: molecular mechanisms and physi... | KEEP AS NON CORE | Summary: The reviewed mechanism supports contextual CMA regulation. Reason: The cited review describes work later published as PMID20797626. Its regulatory interpretation is supported; GFAP is not established as the degraded substrate. |
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Download this section (compressed HTML)Q: Which exact GFAP perturbation or assay supports the two PMID:26571399 neural-crest and enteric-development annotations? The inspected original and supplement leave the gene-to-experiment link unresolved.
Suggested experts: Enteric nervous-system curators, Original study authors
Q: Can original clone sequences reconcile TP53BP2 Q05BL1 with the HuRI partner, NEK6 Q9HC98-4 with source Q9HC98-1, and the ZNF19/RPL27 and BRK1/VHL accession–gene conflicts in the Haenig interaction records?
Suggested experts: Molecular interaction database curators, Original interaction-screen authors
Q: How do the three sequence-defined GFAP splice products differ in endogenous human filament assembly and peripheral lysosomal regulation at physiological expression ratios?
Suggested experts: Intermediate-filament specialists, Chaperone-mediated autophagy specialists
Experiment: Compare sequence-verified alpha, epsilon and kappa at controlled ratios in human astrocytes, measuring filament incorporation and insoluble assemblies separately from protein abundance.
Hypothesis: Carboxyl-terminal differences alter coassembly in a manner that depends on relative product abundance.
Experiment: Resolve soluble and lysosome-associated GFAP pools in human astrocytes and test LAMP2A-complex stability and substrate uptake separately after GFAP perturbation.
Hypothesis: The two-pool regulatory mechanism reported in rodent systems can be distinguished from a requirement for initial LAMP2A-complex assembly.
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