GLYCTK

UniProt ID: Q8IVS8
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for GLYCTK

Existing Annotations Review

GO Term Evidence Action Reason
GO:0005737 cytoplasm
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008887 glycerate kinase activity
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0000166 nucleotide binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005524 ATP binding
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005739 mitochondrion
IEA
GO_REF:0000044 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008887 glycerate kinase activity
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016301 kinase activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016740 transferase activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:16189514
Towards a proteome-scale map of the human protein-protein in... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
GO:0005515 protein binding
IPI
PMID:19060904
An empirical framework for binary interactome mapping. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:19060904
An empirical framework for binary interactome mapping.
GO:0005515 protein binding
IPI
PMID:25416956
A proteome-scale map of the human interactome network. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:25416956
A proteome-scale map of the human interactome network.
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005829 cytosol
IDA
GO_REF:0000052 		PENDING
Summary: TODO: Review this GOA annotation
GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
TAS
Reactome:R-HSA-70350 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008887 glycerate kinase activity
EXP
PMID:2537226
D-glycerate kinase deficiency as a cause of D-glyceric acidu... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:2537226
D-glycerate kinase deficiency as a cause of D-glyceric aciduria.
GO:0005739 mitochondrion
HTP
PMID:34800366
Quantitative high-confidence human mitochondrial proteome an... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:34800366
Epub 2021 Nov 19. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
GO:0008887 glycerate kinase activity
IDA
PMID:31837836
d-Glycerate kinase deficiency in a neuropediatric patient. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31837836
2019 Dec 11. d-Glycerate kinase deficiency in a neuropediatric patient.
GO:0008887 glycerate kinase activity
IMP
PMID:31837836
d-Glycerate kinase deficiency in a neuropediatric patient. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:31837836
2019 Dec 11. d-Glycerate kinase deficiency in a neuropediatric patient.
GO:0005829 cytosol
TAS
Reactome:R-HSA-6799495 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005737 cytoplasm
IDA
PMID:16753811
Isolation and characterization of the human D-glyceric acide... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16753811
Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.
GO:0006468 protein phosphorylation
IDA
PMID:16753811
Isolation and characterization of the human D-glyceric acide... 		REMOVE
Summary: MISANNOTATION: GLYCTK is a glycerate kinase (EC 2.7.1.31), NOT a protein kinase. Its catalytic activity is "(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP" - it phosphorylates the sugar D-glycerate, not proteins. PMID:16753811 describes glycerate kinase characterization with no mention of protein phosphorylation. GLYCTK already has the correct annotation GO:0008887 "glycerate kinase activity". Carbohydrate phosphorylation is the appropriate BP term, not protein phosphorylation.
Supporting Evidence:
PMID:16753811
Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.
GO:0008887 glycerate kinase activity
IDA
PMID:16753811
Isolation and characterization of the human D-glyceric acide... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16753811
Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.

References

GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
PMID:16753811
Isolation and characterization of the human D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its alternatively splicing variant GLYCTK2.
PMID:19060904
An empirical framework for binary interactome mapping.
PMID:2537226
D-glycerate kinase deficiency as a cause of D-glyceric aciduria.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:31837836
d-Glycerate kinase deficiency in a neuropediatric patient.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:34800366
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Reactome:R-HSA-6799495
GLYCTK phosphorylates DGA to 3PDGA
Reactome:R-HSA-70350
Fructose catabolism

📄 View Raw YAML

 
id: Q8IVS8
gene_symbol: GLYCTK
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for GLYCTK'
existing_annotations:
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008887
      label: glycerate kinase activity
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0000166
      label: nucleotide binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005524
      label: ATP binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005739
      label: mitochondrion
    evidence_type: IEA
    original_reference_id: GO_REF:0000044
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008887
      label: glycerate kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016301
      label: kinase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016740
      label: transferase activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:16189514
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16189514
          supporting_text: Towards a proteome-scale map of the human 
            protein-protein interaction network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:19060904
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:19060904
          supporting_text: An empirical framework for binary interactome 
            mapping.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:25416956
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:25416956
          supporting_text: A proteome-scale map of the human interactome 
            network.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: IDA
    original_reference_id: GO_REF:0000052
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0061624
      label: fructose catabolic process to hydroxyacetone phosphate and 
        glyceraldehyde-3-phosphate
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-70350
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008887
      label: glycerate kinase activity
    evidence_type: EXP
    original_reference_id: PMID:2537226
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:2537226
          supporting_text: D-glycerate kinase deficiency as a cause of 
            D-glyceric aciduria.
  - term:
      id: GO:0005739
      label: mitochondrion
    evidence_type: HTP
    original_reference_id: PMID:34800366
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:34800366
          supporting_text: Epub 2021 Nov 19. Quantitative high-confidence human 
            mitochondrial proteome and its dynamics in cellular context.
  - term:
      id: GO:0008887
      label: glycerate kinase activity
    evidence_type: IDA
    original_reference_id: PMID:31837836
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31837836
          supporting_text: 2019 Dec 11. d-Glycerate kinase deficiency in a 
            neuropediatric patient.
  - term:
      id: GO:0008887
      label: glycerate kinase activity
    evidence_type: IMP
    original_reference_id: PMID:31837836
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:31837836
          supporting_text: 2019 Dec 11. d-Glycerate kinase deficiency in a 
            neuropediatric patient.
  - term:
      id: GO:0005829
      label: cytosol
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6799495
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005737
      label: cytoplasm
    evidence_type: IDA
    original_reference_id: PMID:16753811
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16753811
          supporting_text: Isolation and characterization of the human 
            D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its 
            alternatively splicing variant GLYCTK2.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IDA
    original_reference_id: PMID:16753811
    review:
      summary: >-
        MISANNOTATION: GLYCTK is a glycerate kinase (EC 2.7.1.31), NOT a protein kinase.
        Its catalytic activity is "(R)-glycerate + ATP = (2R)-3-phosphoglycerate +
        ADP"
        - it phosphorylates the sugar D-glycerate, not proteins. PMID:16753811 describes
        glycerate kinase characterization with no mention of protein phosphorylation.
        GLYCTK already has the correct annotation GO:0008887 "glycerate kinase activity".
        Carbohydrate phosphorylation is the appropriate BP term, not protein phosphorylation.
      action: REMOVE
      supported_by:
        - reference_id: PMID:16753811
          supporting_text: Isolation and characterization of the human 
            D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its 
            alternatively splicing variant GLYCTK2.
  - term:
      id: GO:0008887
      label: glycerate kinase activity
    evidence_type: IDA
    original_reference_id: PMID:16753811
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16753811
          supporting_text: Isolation and characterization of the human 
            D-glyceric acidemia related glycerate kinase gene GLYCTK1 and its 
            alternatively splicing variant GLYCTK2.
references:
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000044
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
      Location vocabulary mapping, accompanied by conservative changes to GO 
      terms applied by UniProt
    findings: []
  - id: GO_REF:0000052
    title: Gene Ontology annotation based on curation of immunofluorescence data
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:16189514
    title: Towards a proteome-scale map of the human protein-protein interaction
      network.
    findings: []
  - id: PMID:16753811
    title: Isolation and characterization of the human D-glyceric acidemia 
      related glycerate kinase gene GLYCTK1 and its alternatively splicing 
      variant GLYCTK2.
    findings: []
  - id: PMID:19060904
    title: An empirical framework for binary interactome mapping.
    findings: []
  - id: PMID:2537226
    title: D-glycerate kinase deficiency as a cause of D-glyceric aciduria.
    findings: []
  - id: PMID:25416956
    title: A proteome-scale map of the human interactome network.
    findings: []
  - id: PMID:31837836
    title: d-Glycerate kinase deficiency in a neuropediatric patient.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:34800366
    title: Quantitative high-confidence human mitochondrial proteome and its 
      dynamics in cellular context.
    findings: []
  - id: Reactome:R-HSA-6799495
    title: GLYCTK phosphorylates DGA to 3PDGA
    findings: []
  - id: Reactome:R-HSA-70350
    title: Fructose catabolism
    findings: []