GMFG

UniProt ID: O60234
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for GMFG

Existing Annotations Review

GO Term Evidence Action Reason
GO:0071933 Arp2/3 complex binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0030864 cortical actin cytoskeleton
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071846 actin filament debranching
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0007165 signal transduction
IEA
GO_REF:0000108 		PENDING
Summary: TODO: Review this GOA annotation
GO:0003779 actin binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0008083 growth factor activity
IEA
GO_REF:0000043 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071846 actin filament debranching
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0071933 Arp2/3 complex binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6798748 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005576 extracellular region
TAS
Reactome:R-HSA-6800434 		PENDING
Summary: TODO: Review this GOA annotation
GO:0034774 secretory granule lumen
TAS
Reactome:R-HSA-6798748 		PENDING
Summary: TODO: Review this GOA annotation
GO:1904813 ficolin-1-rich granule lumen
TAS
Reactome:R-HSA-6800434 		PENDING
Summary: TODO: Review this GOA annotation
GO:0004860 protein kinase inhibitor activity
TAS
PMID:8639570
In vitro inhibition of MAP kinase (ERK1/ERK2) activity by ph... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8639570
In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor (GMF).
GO:0006468 protein phosphorylation
TAS
PMID:7598724
Phorbol ester stimulates rapid intracellular phosphorylation... 		REMOVE
Summary: MISANNOTATION: GMFG (Glia maturation factor gamma) is NOT a kinase. PMID:7598724 describes GMF proteins as SUBSTRATES: "GMF can be phosphorylated in vitro... by PKC, PKA, and CKII" and "Endogenous GMF in astrocytes is phosphorylated". Same paper used for GMFB annotation - GMF family proteins are substrates of kinases, not enzymes that perform phosphorylation.
Supporting Evidence:
PMID:7598724
Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.
GO:0008047 enzyme activator activity
TAS
PMID:8798479
In vitro enhancement of p38 mitogen-activated protein kinase... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:8798479
In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
PMID:7598724
Phorbol ester stimulates rapid intracellular phosphorylation of glia maturation factor.
PMID:8639570
In vitro inhibition of MAP kinase (ERK1/ERK2) activity by phosphorylated glia maturation factor (GMF).
PMID:8798479
In vitro enhancement of p38 mitogen-activated protein kinase activity by phosphorylated glia maturation factor.
Reactome:R-HSA-6798748
Exocytosis of secretory granule lumen proteins
Reactome:R-HSA-6800434
Exocytosis of ficolin-rich granule lumen proteins

📄 View Raw YAML

 
id: O60234
gene_symbol: GMFG
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for GMFG'
existing_annotations:
  - term:
      id: GO:0071933
      label: Arp2/3 complex binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0030864
      label: cortical actin cytoskeleton
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071846
      label: actin filament debranching
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034316
      label: negative regulation of Arp2/3 complex-mediated actin nucleation
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0007165
      label: signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000108
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0003779
      label: actin binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0008083
      label: growth factor activity
    evidence_type: IEA
    original_reference_id: GO_REF:0000043
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071846
      label: actin filament debranching
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0071933
      label: Arp2/3 complex binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798748
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005576
      label: extracellular region
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6800434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0034774
      label: secretory granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6798748
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:1904813
      label: ficolin-1-rich granule lumen
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-6800434
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0004860
      label: protein kinase inhibitor activity
    evidence_type: TAS
    original_reference_id: PMID:8639570
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8639570
          supporting_text: In vitro inhibition of MAP kinase (ERK1/ERK2) 
            activity by phosphorylated glia maturation factor (GMF).
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: TAS
    original_reference_id: PMID:7598724
    review:
      summary: >-
        MISANNOTATION: GMFG (Glia maturation factor gamma) is NOT a kinase. PMID:7598724
        describes GMF proteins as SUBSTRATES: "GMF can be phosphorylated in vitro...
        by PKC, PKA, and CKII" and "Endogenous GMF in astrocytes is phosphorylated".
        Same paper used for GMFB annotation - GMF family proteins are substrates
        of kinases, not enzymes that perform phosphorylation.
      action: REMOVE
      supported_by:
        - reference_id: PMID:7598724
          supporting_text: Phorbol ester stimulates rapid intracellular 
            phosphorylation of glia maturation factor.
  - term:
      id: GO:0008047
      label: enzyme activator activity
    evidence_type: TAS
    original_reference_id: PMID:8798479
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:8798479
          supporting_text: In vitro enhancement of p38 mitogen-activated protein
            kinase activity by phosphorylated glia maturation factor.
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000043
    title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword 
      mapping
    findings: []
  - id: GO_REF:0000108
    title: Automatic assignment of GO terms using logical inference, based on on
      inter-ontology links
    findings: []
  - id: PMID:7598724
    title: Phorbol ester stimulates rapid intracellular phosphorylation of glia 
      maturation factor.
    findings: []
  - id: PMID:8639570
    title: In vitro inhibition of MAP kinase (ERK1/ERK2) activity by 
      phosphorylated glia maturation factor (GMF).
    findings: []
  - id: PMID:8798479
    title: In vitro enhancement of p38 mitogen-activated protein kinase activity
      by phosphorylated glia maturation factor.
    findings: []
  - id: Reactome:R-HSA-6798748
    title: Exocytosis of secretory granule lumen proteins
    findings: []
  - id: Reactome:R-HSA-6800434
    title: Exocytosis of ficolin-rich granule lumen proteins
    findings: []