GPAM

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0005739 mitochondrion	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: mitochondrion: Mitochondrial association is correct but the outer-membrane location is more precise. Reason: Mitochondrial association is correct but the outer-membrane location is more precise. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0004366 glycerol-3-phosphate O-acyltransferase activity	IBA GO_REF:0000033	ACCEPT	Summary: glycerol-3-phosphate O-acyltransferase activity: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0006650 glycerophospholipid metabolic process	IBA GO_REF:0000033	ACCEPT	Summary: glycerophospholipid metabolic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0019432 triglyceride biosynthetic process	IBA GO_REF:0000033	ACCEPT	Summary: triglyceride biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0004366 glycerol-3-phosphate O-acyltransferase activity	IEA GO_REF:0000120	ACCEPT	Summary: glycerol-3-phosphate O-acyltransferase activity: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005741 mitochondrial outer membrane	IEA GO_REF:0000044	ACCEPT	Summary: mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005886 plasma membrane	IEA GO_REF:0000002	REMOVE	Summary: plasma membrane: The human GPAT1 structure and functional study localize GPAT1 to the mitochondrial outer membrane and identify its mitochondrial-targeting region. The electronic plasma-membrane assignment lacks a distinct localization mechanism and conflicts with that supported placement. Reason: The human GPAT1 structure and functional study localize GPAT1 to the mitochondrial outer membrane and identify its mitochondrial-targeting region. The electronic plasma-membrane assignment lacks a distinct localization mechanism and conflicts with that supported placement. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0006629 lipid metabolic process	IEA GO_REF:0000002	ACCEPT	Summary: lipid metabolic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0008654 phospholipid biosynthetic process	IEA GO_REF:0000002	ACCEPT	Summary: phospholipid biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0016746 acyltransferase activity	IEA GO_REF:0000002	MODIFY	Summary: acyltransferase activity: The acyltransferase assignment is correct but glycerol-3-phosphate O-acyltransferase activity identifies the physiological acceptor and reaction. Reason: The acyltransferase assignment is correct but glycerol-3-phosphate O-acyltransferase activity identifies the physiological acceptor and reaction. Proposed replacements: glycerol-3-phosphate O-acyltransferase activity Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups	IEA GO_REF:0000002	MODIFY	Summary: acyltransferase activity, transferring groups other than amino-acyl groups: The acyltransferase assignment is correct but glycerol-3-phosphate O-acyltransferase activity identifies the physiological acceptor and reaction. Reason: The acyltransferase assignment is correct but glycerol-3-phosphate O-acyltransferase activity identifies the physiological acceptor and reaction. Proposed replacements: glycerol-3-phosphate O-acyltransferase activity Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005515 protein binding	IPI PMID:32296183 A reference map of the human binary protein interactome.	UNDECIDED	Summary: protein binding: The PMID:32296183 interaction annotation does not by itself identify a molecular role for GPAM. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title. Reason: The PMID:32296183 interaction annotation does not by itself identify a molecular role for GPAM. The relevant bait/prey or complex evidence must be examined before choosing a more informative binding/regulatory term; no wrong-gene inference is made from a high-throughput study title.
GO:0006654 phosphatidic acid biosynthetic process	TAS Reactome:R-HSA-1483166	ACCEPT	Summary: phosphatidic acid biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0019432 triglyceride biosynthetic process	TAS Reactome:R-HSA-75109	ACCEPT	Summary: triglyceride biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0016024 CDP-diacylglycerol biosynthetic process	IEA GO_REF:0000041	ACCEPT	Summary: CDP-diacylglycerol biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0004366 glycerol-3-phosphate O-acyltransferase activity	EXP PMID:18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransf...	ACCEPT	Summary: glycerol-3-phosphate O-acyltransferase activity: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005739 mitochondrion	HTP PMID:34800366 Quantitative high-confidence human mitochondrial proteome an...	KEEP AS NON CORE	Summary: mitochondrion: Mitochondrial association is correct but the outer-membrane location is more precise. Reason: Mitochondrial association is correct but the outer-membrane location is more precise. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0004366 glycerol-3-phosphate O-acyltransferase activity	ISS GO_REF:0000024	ACCEPT	Summary: glycerol-3-phosphate O-acyltransferase activity: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0004366 glycerol-3-phosphate O-acyltransferase activity	IMP PMID:19075029 The microsomal cardiolipin remodeling enzyme acyl-CoA lysoca...	ACCEPT	Summary: glycerol-3-phosphate O-acyltransferase activity: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0006651 diacylglycerol biosynthetic process	ISS GO_REF:0000024	ACCEPT	Summary: diacylglycerol biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0006654 phosphatidic acid biosynthetic process	ISS GO_REF:0000024	ACCEPT	Summary: phosphatidic acid biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0006655 phosphatidylglycerol biosynthetic process	IMP PMID:19075029 The microsomal cardiolipin remodeling enzyme acyl-CoA lysoca...	UNDECIDED	Summary: phosphatidylglycerol biosynthetic process: The specific phosphatidylglycerol phenotype requires inspection of the original comparative lipid assay. GPAT1 supplies a common precursor, but that alone is not enough to adjudicate this specific experimental annotation. Reason: The specific phosphatidylglycerol phenotype requires inspection of the original comparative lipid assay. GPAT1 supplies a common precursor, but that alone is not enough to adjudicate this specific experimental annotation. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005741 mitochondrial outer membrane	TAS Reactome:R-HSA-1482695	ACCEPT	Summary: mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005741 mitochondrial outer membrane	TAS Reactome:R-HSA-1655837	ACCEPT	Summary: mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005741 mitochondrial outer membrane	TAS Reactome:R-HSA-75886	ACCEPT	Summary: mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0005741 mitochondrial outer membrane	TAS Reactome:R-HSA-8932020	ACCEPT	Summary: mitochondrial outer membrane: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0004366 glycerol-3-phosphate O-acyltransferase activity	IMP PMID:18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransf...	ACCEPT	Summary: glycerol-3-phosphate O-acyltransferase activity: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.
GO:0019432 triglyceride biosynthetic process	IDA PMID:18238778 AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransf...	ACCEPT	Summary: triglyceride biosynthetic process: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Reason: GPAT1 catalyzes the initial acyl-CoA-dependent step that supplies lysophosphatidic acid for glycerolipid synthesis at the mitochondrial outer membrane. Participation in downstream lipid biosynthetic routes does not mean GPAT1 catalyzes every later reaction. The human structural study independently establishes GPAT1 identity and membrane association. Supporting Evidence: PMID:36522428 Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis.

Gene Description

Existing Annotations Review

Core Functions

GPAM encodes mitochondrial glycerol-3-phosphate acyltransferase 1, which transfers a fatty acyl group from acyl-CoA to the sn-1 position of glycerol-3-phosphate to produce lysophosphatidic acid.

References

Deep Research

Falcon

📚 Additional Documentation

Notes

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