GRB2 (growth factor receptor-bound protein 2) is a ubiquitously expressed, non-catalytic cytoplasmic signaling adaptor built from an N-terminal SH3 domain, a central SH2 domain, and a C-terminal SH3 domain. Its SH2 domain recognizes phosphotyrosine motifs on activated receptor tyrosine kinases and phosphorylated scaffold proteins (e.g. SHC1, IRS1, LAT), while its two SH3 domains bind proline-rich motifs of downstream effectors, most notably the Ras guanine-nucleotide exchange factor SOS. By simultaneously engaging a phosphorylated receptor and SOS, GRB2 recruits SOS to the plasma membrane and couples receptor activation to Ras loading and the RAF-MEK-ERK (MAPK) cascade, the central mechanism by which extracellular growth-factor signals drive proliferation, differentiation, survival, and migration. GRB2 also assembles broader receptor-proximal signaling complexes (nucleating LAT microclusters in immunoreceptor signaling, linking receptors to Gab scaffolds and the PI3K-AKT branch, and binding partners such as CBL to promote receptor endocytosis and signal attenuation). It functions predominantly in the cytosol and at the cytoplasmic face of the plasma membrane, relocating to activated membrane receptors and to endosomes during receptor trafficking; nuclear pools have also been reported. GRB2 can homodimerize, and dimeric GRB2 can restrain basal signaling of some receptors such as FGFR2.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0001784 phosphotyrosine residue binding | IBA GO_REF:0000033 | ACCEPT | Summary: IBA: phosphotyrosine residue binding, the molecular activity of the GRB2 central SH2 domain that recognizes tyrosine-phosphorylated motifs on activated receptors and scaffolds. Reason: This is a core GRB2 molecular function. The SH2 domain binds receptor/scaffold phosphotyrosine; the IBA reflects a sound phylogenetic assignment across the GRB2/Sem-5/DRK family (GRB2 appears in its own WITH/FROM because it has direct experimental grounding, which is expected, not circular). Supporting Evidence: PMID:1322798 GRB2 associates with tyrosine-phosphorylated epidermal growth factor receptors (EGFRs) and platelet-derived growth factor receptors (PDGFRs) via its SH2 domain |
| GO:0001784 phosphotyrosine residue binding | IPI PMID:20624904 Tarp regulates early Chlamydia-induced host cell survival th... | ACCEPT | Summary: IPI: GRB2 SH2 domain binding a phosphotyrosine-containing ligand, assayed on an SH2/PTB-domain protein microarray. Reason: Direct measurement of GRB2 SH2-domain phosphotyrosine binding; consistent with GRB2's core SH2 function. The specific partner (a Chlamydia Tarp phosphopeptide) is incidental to the molecular activity being demonstrated. |
| GO:0003723 RNA binding | HDA PMID:22658674 Insights into RNA biology from an atlas of mammalian mRNA-bi... | KEEP AS NON CORE | Summary: HDA: GRB2 identified as an RNA-binding protein in a proteome-wide mRNA interactome-capture (UV crosslinking) screen. Reason: A high-throughput identification, not a canonical or core GRB2 function; there is some corroboration that nuclear GRB2 influences microRNA expression (PMID:37328606), but RNA binding is not part of GRB2's adaptor role. Retained as non-core rather than removed, per the policy against overruling experimental/high-throughput assays on incomplete grounds. |
| GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (ortholog transfer): transmembrane receptor protein tyrosine kinase adaptor activity. Reason: This precisely describes GRB2's defining molecular function: coupling activated receptor tyrosine kinases to downstream effectors. Core. |
| GO:0005091 guanyl-nucleotide exchange factor adaptor activity | IDA PMID:8386805 Grb2 mediates the EGF-dependent activation of guanine nucleo... | ACCEPT | Summary: IDA: guanyl-nucleotide exchange factor adaptor activity - GRB2 couples activated RTKs to the Ras GEF (SOS), the canonical GRB2 output. Reason: Core GRB2 function. GRB2 forms a complex with a Ras GEF that binds the activated EGF receptor, coupling the kinase to Ras activation. Supporting Evidence: PMID:8386805 Cellular Grb2 appears to form a complex with a guanine-nucleotide-exchange factor for Ras, which binds to the ligand-activated EGF receptor, allowing the tyrosine kinase to modulate Ras activity. |
| GO:0005091 guanyl-nucleotide exchange factor adaptor activity | IEA GO_REF:0000120 | ACCEPT | Summary: IEA (ARBA + ortholog): guanyl-nucleotide exchange factor adaptor activity. Reason: Duplicates the experimentally supported GEF adaptor activity (see IDA on PMID:8386805). Correct core function. |
| GO:0005154 epidermal growth factor receptor binding | IBA GO_REF:0000033 | ACCEPT | Summary: IBA: epidermal growth factor receptor binding - GRB2 SH2 domain binds phosphorylated EGFR. Reason: GRB2 binding to EGFR is one of the best-established GRB2 interactions and underlies EGFR-Ras-MAPK signaling; the phylogenetic assignment is sound. Supporting Evidence: PMID:1322798 GRB2 associates with tyrosine-phosphorylated epidermal growth factor receptors (EGFRs) and platelet-derived growth factor receptors (PDGFRs) via its SH2 domain |
| GO:0005154 epidermal growth factor receptor binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | ACCEPT | Summary: IPI: GRB2 binds EGFR (P00533), demonstrated by quantitative EGF-signaling proteomics. Reason: Direct interaction with EGFR is canonical for GRB2 and is more informative than generic protein binding. |
| GO:0005168 neurotrophin TRKA receptor binding | IPI PMID:15488758 TrkA alternative splicing: a regulated tumor-promoting switc... | KEEP AS NON CORE | Summary: IPI: GRB2 binds the neurotrophin receptor TrkA/NTRK1 (P04629). Reason: A specific instance of GRB2's general RTK-adaptor function (SH2 binding to a receptor phosphotyrosine). Real interaction but one of many receptor partners; retained as non-core rather than a distinct core function. |
| GO:0005515 protein binding | IPI PMID:10026169 Identification of Grb4/Nckbeta, a src homology 2 and 3 domai... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10206341 Characterization of interactions of Nck with Sos and dynamin... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10229072 Association of Nck with tyrosine-phosphorylated SLP-76 in ac... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10318918 NS5A, a nonstructural protein of hepatitis C virus, binds gr... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10356320 Solution structure of the SH2 domain of Grb2 complexed with ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10377264 Identification of Tyr-703 and Tyr-936 as the primary associa... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10660596 Tyrosine dephosphorylation and deactivation of insulin recep... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10660596 Tyrosine dephosphorylation and deactivation of insulin recep... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10660620 PILRalpha, a novel immunoreceptor tyrosine-based inhibitory ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10811803 Association of Grb2, Gads, and phospholipase C-gamma 1 with ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10887132 The Grb2 binding site is required for the induction of chron... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:10980613 Generation of novel cytoplasmic forms of protein tyrosine ph... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11278465 The tyrosine kinase Hck is an inhibitor of HIV-1 replication... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11432792 Analysis of tyrosine phosphorylation-dependent protein-prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11533253 Recruitment of the class II phosphoinositide 3-kinase C2beta... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11684012 Site-specific incorporation of a phosphotyrosine mimetic rev... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11741929 Phosphorylation-dependent interactions between ADAM15 cytopl... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11827484 Crystal structures of the SH2 domain of Grb2: highlight on t... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11882361 The lymphoid protein tyrosine phosphatase Lyp interacts with... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11896612 Use of signal specific receptor tyrosine kinase oncoproteins... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:11923305 Mitotic activation of protein-tyrosine phosphatase alpha and... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12091307 unc-53 controls longitudinal migration in C. elegans. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12091307 unc-53 controls longitudinal migration in C. elegans. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12091307 unc-53 controls longitudinal migration in C. elegans. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12091307 unc-53 controls longitudinal migration in C. elegans. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12213123 Novel peptide inhibitors for Grb2 SH2 domain and their detec... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12359715 Molecular cloning of a novel gene encoding a membrane-associ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:12852788 Adaptor signalling proteins Grb2 and Grb7 are recruited by h... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:14679214 A novel proteomic screen for peptide-protein interactions. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:14679214 A novel proteomic screen for peptide-protein interactions. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:14679214 A novel proteomic screen for peptide-protein interactions. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:14722116 The importance of three membrane-distal tyrosines in the ada... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:14993658 The hepatitis C virus NS5A protein binds to members of the S... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:15467741 Magicin, a novel cytoskeletal protein associates with the NF... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:15558030 Characterization of VIK-1: a new Vav-interacting Kruppel-lik... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:15657067 Phosphotyrosine signaling networks in epidermal growth facto... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:15784897 Further studies on hepatitis C virus NS5A-SH3 domain interac... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:15929943 Novel Src homology 3 domain-binding motifs identified from p... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16253990 Increased proliferation and altered growth factor dependence... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16273093 A quantitative protein interaction network for the ErbB rece... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16273093 A quantitative protein interaction network for the ErbB rece... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16374509 Identification of preferred protein interactions by phage-di... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16374509 Identification of preferred protein interactions by phage-di... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16407827 The elucidation of novel SH2 binding sites on PLD2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16520382 Sos-mediated activation of rac1 by p66shc. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16520382 Sos-mediated activation of rac1 by p66shc. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16696976 Two mechanistically distinct forms of endocytosis in adrenal... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16730941 A systematic analysis of human CHMP protein interactions: ad... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16799092 Dynamic profiling of the post-translational modifications an... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16893902 A Src homology 3-binding sequence on the C terminus of Sprou... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16899217 Magicin associates with the Src-family kinases and is phosph... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16912232 Human SLP-65 isoforms contribute differently to activation a... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:16938345 Evidence of LAT as a dual substrate for Lck and Syk in T lym... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17094785 Identification and functional characterization of an Src hom... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17235283 Efficient T-cell receptor signaling requires a high-affinity... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17276458 The Grb2/PLD2 interaction is essential for lipase activity, ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17474147 Systematic identification of SH3 domain-mediated human prote... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:17974561 Tesk1 interacts with Spry2 to abrogate its inhibition of ERK... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:18273061 Structural basis for a novel intrapeptidyl H-bond and revers... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:18624398 Protein interaction data set highlighted with human Ras-MAPK... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:18647389 The central proline rich region of POB1/REPS2 plays a regula... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:18654987 Identification of multi-SH3 domain-containing protein intera... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:18692475 A protein domain-based interactome network for C. elegans ea... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19172738 Phosphorylation-dependent binding of 14-3-3 terminates signa... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19323566 SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within t... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19380743 Charting the molecular network of the drug target Bcr-Abl. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19509291 GAREM, a novel adaptor protein for growth factor receptor-bo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19615732 Defining the human deubiquitinating enzyme interaction lands... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19798056 Participation of Tom1L1 in EGF-stimulated endocytosis of EGF... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:19914172 KIF26A is an unconventional kinesin and regulates GDNF-Ret s... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20473329 SIRPalpha1 receptors interfere with the EGFRvIII signalosome... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20933011 FCRL6 receptor: expression and associated proteins. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21179510 Histidine domain-protein tyrosine phosphatase interacts with... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21189249 T cell receptor (TCR)-induced tyrosine phosphorylation dynam... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21278786 PI3K inhibition results in enhanced HER signaling and acquir... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21278786 PI3K inhibition results in enhanced HER signaling and acquir... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21278788 Translationally controlled tumor protein induces human breas... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21706016 Selected reaction monitoring mass spectrometry reveals the d... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21725282 Activation of Src and transformation by an RPTPΞ± splice muta... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21725358 The SRC-associated protein CUB Domain-Containing Protein-1 r... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21822214 The B-cell antigen receptor signals through a preformed tran... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21900206 A directed protein interaction network for investigating int... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21900206 A directed protein interaction network for investigating int... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21900206 A directed protein interaction network for investigating int... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21900206 A directed protein interaction network for investigating int... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21930792 SCIMP, a transmembrane adaptor protein involved in major his... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:22057045 Phosphotyrosine mediated protein interactions of the discoid... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:22323290 FCH domain only-2 organizes clathrin-coated structures and i... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:22536782 Bivalent binding drives the formation of the Grb2-Gab1 signa... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:22726438 Inhibition of basal FGF receptor signaling by dimeric Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:22801373 Protein tyrosine phosphatase Ξ± phosphotyrosyl-789 binds BCAR... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:23178716 SnoN/SkiL expression is modulated via arsenic trioxide-induc... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:23178716 SnoN/SkiL expression is modulated via arsenic trioxide-induc... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:23460737 GRB2-mediated recruitment of THEMIS to LAT is essential for ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:23799367 Threshold-controlled ubiquitination of the EGFR directs rece... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:23799367 Threshold-controlled ubiquitination of the EGFR directs rece... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24189400 Perturbation of the mutated EGFR interactome identifies vuln... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24658140 The mammalian-membrane two-hybrid assay (MaMTH) for probing ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24728074 Enhanced prediction of Src homology 2 (SH2) domain binding p... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:24902122 The Haemophilus ducreyi LspA1 protein inhibits phagocytosis ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25036101 Identification of SH3 domain proteins interacting with the c... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25036637 A quantitative chaperone interaction network reveals the arc... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25092874 RHEX, a novel regulator of human erythroid progenitor cell e... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25535246 A THEMIS:SHP1 complex promotes T-cell survival. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25535246 A THEMIS:SHP1 complex promotes T-cell survival. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25814554 Phospho-tyrosine dependent protein-protein interaction netwo... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25819436 A single PXXP motif in the C-terminal region of srGAP3 media... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:25825872 Preferred SH3 domain partners of ADAM metalloproteases inclu... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:27059931 Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA p... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:27107012 Pooled-matrix protein interaction screens using Barcode Fusi... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28046066 HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28065597 A Global Analysis of the Receptor Tyrosine Kinase-Protein Ph... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28330616 Systematic Analysis of Human Protein Phosphatase Interaction... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:29997244 LuTHy: a double-readout bioluminescence-based two-hybrid tec... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:29997244 LuTHy: a double-readout bioluminescence-based two-hybrid tec... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31467278 Maximizing binary interactome mapping with a minimal number ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31515488 Extensive disruption of protein interactions by genetic vari... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31585087 Oncogenic Mutations Rewire Signaling Pathways by Switching P... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31585087 Oncogenic Mutations Rewire Signaling Pathways by Switching P... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31820037 Elucidation of protein interactions necessary for the mainte... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31820037 Elucidation of protein interactions necessary for the mainte... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31820037 Elucidation of protein interactions necessary for the mainte... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32203420 Systems analysis of RhoGEF and RhoGAP regulatory proteins re... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32296183 A reference map of the human binary protein interactome. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:32911434 A functionally defined high-density NRF2 interactome reveals... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:34591642 A protein network map of head and neck cancer reveals PIK3CA... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:35384245 Physical and functional interactome atlas of human receptor ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:37398436 AI-guided pipeline for protein-protein interaction drug disc... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:37776851 Analysis of proteome-wide degradation dynamics in ALS SOD1 i... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:38182563 GRB2 is a BECN1 interacting protein that regulates autophagy... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:39251607 Systematic identification of post-transcriptional regulatory... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7504175 Pleiotropic insulin signals are engaged by multisite phospho... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7518560 Hierarchy of binding sites for Grb2 and Shc on the epidermal... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7518772 Phosphorylation of receptor protein-tyrosine phosphatase alp... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7522233 Interleukin (IL)-3 and granulocyte/macrophage colony-stimula... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7523381 The ubiquitously expressed Syp phosphatase interacts with c-... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7523381 The ubiquitously expressed Syp phosphatase interacts with c-... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7523381 The ubiquitously expressed Syp phosphatase interacts with c-... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7527391 Independent binding of peptide ligands to the SH2 and SH3 do... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7537265 Functional interaction between c-Src and its mitotic target,... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7597091 Stimulation of human monocytes with macrophage colony-stimul... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7629138 Differential interactions of human Sos1 and Sos2 with Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7629138 Differential interactions of human Sos1 and Sos2 with Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7773779 NMR structure of the N-terminal SH3 domain of GRB2 and its c... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:7929073 5-Lipoxygenase contains a functional Src homology 3-binding ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8112292 Bcr-Abl oncoproteins bind directly to activators of the Ras ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8491186 The SH2/SH3 domain-containing protein GRB2 interacts with ty... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8491186 The SH2/SH3 domain-containing protein GRB2 interacts with ty... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8663178 Rapid identification of phosphopeptide ligands for SH2 domai... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8798570 Ligand activation of ELK receptor tyrosine kinase promotes i... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8816475 Evidence for in vivo phosphorylation of the Grb2 SH2-domain ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8887653 The phosphotyrosine interaction domains of X11 and FE65 bind... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8892607 Evidence that the Wiskott-Aldrich syndrome protein may be in... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8939605 The Shc adaptor protein is highly phosphorylated at conserve... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8940013 The Grb2-mSos1 complex binds phosphopeptides with higher aff... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8940013 The Grb2-mSos1 complex binds phosphopeptides with higher aff... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8940013 The Grb2-mSos1 complex binds phosphopeptides with higher aff... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8955135 Co-expression with BCR induces activation of the FES tyrosin... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8959326 Multiple in vivo phosphorylated tyrosine phosphatase SHP-2 e... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8995379 The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 pro... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:8995379 The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 pro... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9020117 Subsets of epidermal growth factor receptors during activati... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9020117 Subsets of epidermal growth factor receptors during activati... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9045636 Interaction between Sam68 and Src family tyrosine kinases, F... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9148935 Focal adhesion kinase overexpression enhances ras-dependent ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9174058 Tyrosine phosphorylation of p120cbl in BCR/abl transformed h... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9175774 An alternative to phosphotyrosine-containing motifs for bind... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9178760 Intracellular signaling of the Ufo/Axl receptor tyrosine kin... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9178913 Bcr phosphorylated on tyrosine 177 binds Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9254595 Thermodynamic and structural analysis of phosphotyrosine pol... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9346925 SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste2... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9447984 Regulation of Sos activity by intramolecular interactions. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9489702 LAT: the ZAP-70 tyrosine kinase substrate that links T cell ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9544989 Shc phosphotyrosine-binding domain dominantly interacts with... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9569023 Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9569023 Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9569023 Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9697839 BLNK: a central linker protein in B cell activation. | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9788432 The germinal center kinase (GCK)-related protein kinases HPK... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005515 protein binding | IPI PMID:9922133 Dual function C-terminal domain of dynamin-1: modulation of ... | REMOVE | Summary: Generic protein binding (IPI) recording a physical interaction of GRB2 with a specific partner. This term does not identify GRB2's molecular function. Reason: Per curation policy, GO:0005515 protein binding is uninformative: it does not specify what GRB2 does molecularly. GRB2's actual adaptor function is captured by specific terms (e.g. GO:0001784 phosphotyrosine residue binding, GO:0030674 protein-macromolecule adaptor activity, GO:0005091 guanyl-nucleotide exchange factor adaptor activity, GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity). Removal is a statement about the annotation's lack of functional information, not a claim that the reported interaction is false. |
| GO:0005634 nucleus | EXP PMID:37328606 Regulation of microRNA expression by the adaptor protein GRB... | KEEP AS NON CORE | Summary: EXP: nuclear localization of GRB2 (nuclear GRB2 regulates microRNA expression). Reason: Nuclear GRB2 is documented but is a context-specific, non-canonical location distinct from GRB2's core cytoplasmic/membrane adaptor role. |
| GO:0005634 nucleus | IDA PMID:21179510 Histidine domain-protein tyrosine phosphatase interacts with... | KEEP AS NON CORE | Summary: IDA: nuclear localization observed by immunocytochemistry (HD-PTP/PTPN23 interaction study). Reason: Consistent with reported nuclear GRB2 pools; non-core relative to the cytoplasmic/membrane adaptor function. |
| GO:0005634 nucleus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA: nucleus, from UniProt subcellular-location vocabulary mapping. Reason: Consistent with reported nuclear localization; non-core. |
| GO:0005654 nucleoplasm | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: IBA: is active in nucleoplasm. Reason: Consistent with a nuclear GRB2 pool; non-core relative to the canonical cytoplasmic/membrane adaptor role. |
| GO:0005737 cytoplasm | EXP PMID:30282717 The 11-Kilodalton Nonstructural Protein of Human Parvovirus ... | ACCEPT | Summary: EXP: cytoplasmic localization of GRB2. Reason: Cytoplasm is a correct, core basal location for this soluble adaptor. |
| GO:0005737 cytoplasm | EXP PMID:37328606 Regulation of microRNA expression by the adaptor protein GRB... | ACCEPT | Summary: EXP: cytoplasmic localization of GRB2. Reason: Cytoplasm is a correct, core basal location for this soluble adaptor. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: IBA: is active in cytoplasm. Reason: GRB2 acts as a cytoplasmic adaptor; phylogenetically and experimentally supported. |
| GO:0005737 cytoplasm | IDA PMID:21179510 Histidine domain-protein tyrosine phosphatase interacts with... | ACCEPT | Summary: IDA: cytoplasmic localization. Reason: Correct core location for the soluble adaptor. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: IEA: cytoplasm (ortholog/subcell mapping). Reason: Correct core location. |
| GO:0005768 endosome | IDA PMID:21179510 Histidine domain-protein tyrosine phosphatase interacts with... | KEEP AS NON CORE | Summary: IDA: endosome localization. Reason: Consistent with GRB2's role during receptor endocytic trafficking; a context-specific location rather than the core cytosolic/membrane site. |
| GO:0005768 endosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA: endosome (subcell mapping). Reason: Consistent with receptor trafficking; non-core location. |
| GO:0005794 Golgi apparatus | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: IEA: Golgi apparatus (subcell mapping). Reason: Peripheral, weakly supported location; non-core. |
| GO:0005794 Golgi apparatus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: ISS: Golgi apparatus (ortholog). Reason: Peripheral location inferred by similarity; non-core. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | IEA GO_REF:0000117 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS PMID:14722116 The importance of three membrane-distal tyrosines in the ada... | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109699 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109813 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109822 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-109823 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225950 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225951 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225957 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1225961 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1226012 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1226014 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1226016 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1250380 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1250383 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1295613 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306957 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306963 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306965 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306969 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1306972 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433428 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433454 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433471 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1433514 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1549564 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1562641 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177920 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177923 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177924 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177926 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177927 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177930 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177931 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177935 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177936 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177938 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177939 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177941 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177943 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177944 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-177945 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-179467 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-182994 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-183002 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-183036 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-183052 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-183058 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-183067 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-183084 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1839095 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1839102 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1839107 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1839110 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1839114 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-186826 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-186834 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2029466 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-204871 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205234 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205244 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-205286 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210974 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-210977 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2179407 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2179415 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2197690 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2197691 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2197698 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396561 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396594 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396599 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2396606 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424476 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424477 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424481 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424484 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424485 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424486 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2424487 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730833 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730837 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730840 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730841 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730842 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730844 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730847 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730851 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730856 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730858 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730870 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730889 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2730892 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-354087 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-354165 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-388814 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-389348 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-389350 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-389352 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-389354 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-389919 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-391153 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-392051 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-392053 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-392054 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453104 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-453111 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-508247 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637764 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637765 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637770 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637798 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637801 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637806 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5637808 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654392 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654402 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654406 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654413 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654416 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654423 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654426 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654586 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654591 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654592 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654594 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654596 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654597 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654600 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654612 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654614 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654615 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654618 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654620 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654622 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654637 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654640 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654641 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654643 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654646 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654647 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654659 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654662 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654663 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654664 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654667 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654669 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654672 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654673 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654677 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654679 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654684 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654690 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654692 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654697 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654701 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654705 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654709 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654714 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654717 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654729 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654730 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5654734 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655233 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655235 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655240 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655241 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655245 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655248 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655252 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655263 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655266 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655277 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655285 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655289 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655290 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655295 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655315 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655320 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655323 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655326 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655347 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5655348 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5672965 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5685366 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5686073 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5686074 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5686315 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-74736 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-74746 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-879917 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851804 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851827 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851899 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851900 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851919 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851933 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8851954 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8852019 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8853734 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8853774 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8853793 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854897 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854899 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8854905 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8855508 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8865994 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8866279 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8867041 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8867044 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8867047 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8867754 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8867756 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868071 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868072 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868230 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868236 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868648 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868651 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868658 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868659 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868660 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8868661 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8869438 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8871193 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8871194 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8874685 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875183 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875451 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875482 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875490 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875540 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875558 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875568 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875576 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875591 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875659 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8875661 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8876240 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8876258 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8951490 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-8983384 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9018766 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9029150 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9032073 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-912527 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-912627 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-913424 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9606887 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9607301 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9607304 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9634402 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9634418 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664918 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664933 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664940 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664983 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9664991 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665000 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665009 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665404 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665407 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665408 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665409 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665413 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665415 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665417 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665698 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665699 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665700 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9665707 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670428 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9670436 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672158 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672163 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672164 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9672170 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9674816 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9695841 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9695845 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9695853 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698000 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698003 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698005 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698007 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698008 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698013 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698029 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698170 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9698174 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9703430 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9703434 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9703438 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9703441 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9710914 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9724099 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-983703 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9842655 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9842665 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9842669 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-1250468 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-1250472 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-1250475 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-1250500 | ACCEPT | Summary: Cytosolic localization of GRB2. GRB2 is a soluble adaptor that resides in the cytosol under basal conditions and translocates to the cytoplasmic face of membranes upon receptor activation. Reason: Cytosol is a correct and well-supported basal location for this soluble SH3-SH2-SH3 adaptor; the many Reactome TAS rows are redundant provenance for the same, correct location assertion. |
| GO:0005886 plasma membrane | IBA GO_REF:0000033 | ACCEPT | Summary: IBA: is active in plasma membrane - GRB2 functions at the cytoplasmic face of the plasma membrane on receptor activation. Reason: Core functional location: GRB2 relocalizes to activated membrane receptors to nucleate SOS-Ras signaling. |
| GO:0005886 plasma membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA: plasma membrane (ortholog transfer). Reason: Correct functional location on receptor activation. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-1112666 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2076220 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2316434 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-2400009 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9606151 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9606887 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-9691421 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005886 plasma membrane | TAS Reactome:R-HSA-983703 | ACCEPT | Summary: TAS (Reactome): plasma membrane localization within signaling events. Reason: Correct functional location; GRB2 is recruited to the plasma membrane at activated receptors. |
| GO:0005911 cell-cell junction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (ortholog): cell-cell junction. Reason: Peripheral ortholog-based location; non-core. |
| GO:0005938 cell cortex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (ortholog): is active in cell cortex. Reason: Peripheral ortholog-based location consistent with cortical/actin-associated signaling; non-core. |
| GO:0007165 signal transduction | IBA GO_REF:0000033 | ACCEPT | Summary: IBA: involved in signal transduction. Reason: Correct high-level process for this signaling adaptor; retained though general. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: IEA: involved in epidermal growth factor receptor signaling pathway. Reason: Core process: GRB2 is a central component of EGFR signaling. |
| GO:0007173 epidermal growth factor receptor signaling pathway | IMP PMID:8253073 Ash/Grb-2, a SH2/SH3-containing protein, couples to signalin... | ACCEPT | Summary: IMP: GRB2 (Ash) required for EGF-induced mitogenesis/signaling (anti-Ash antibody microinjection abolished EGF responses). Reason: Loss-of-function evidence that GRB2 is required for EGFR-driven signaling; core process. Supporting Evidence: PMID:8253073 The antibody abolished both S phase entry and the reorganization of actin assembly to ruffle formation upon stimulation with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). |
| GO:0007173 epidermal growth factor receptor signaling pathway | TAS PMID:1322798 The SH2 and SH3 domain-containing protein GRB2 links recepto... | ACCEPT | Summary: TAS: EGFR signaling pathway (GRB2 links RTKs to Ras). Reason: Core process, supported by the founding GRB2 study. Supporting Evidence: PMID:1322798 GRB2 associates with tyrosine-phosphorylated epidermal growth factor receptors (EGFRs) and platelet-derived growth factor receptors (PDGFRs) via its SH2 domain |
| GO:0007265 Ras protein signal transduction | IEA GO_REF:0000117 | ACCEPT | Summary: IEA: involved in Ras protein signal transduction. Reason: Core process: GRB2 couples RTKs to Ras via SOS. |
| GO:0007265 Ras protein signal transduction | TAS PMID:8253073 Ash/Grb-2, a SH2/SH3-containing protein, couples to signalin... | ACCEPT | Summary: TAS: Ras protein signal transduction. Reason: Core process; GRB2-SOS-Ras is the canonical GRB2 axis. Supporting Evidence: PMID:8253073 Ash plays a critical role in the signaling of both pathways downstream from growth factor receptors to Ras and Rac |
| GO:0008180 COP9 signalosome | IBA GO_REF:0000033 | REMOVE | Summary: IBA: asserts GRB2 is part of the COP9 signalosome. Reason: COP9 signalosome (CSN) is a defined GPS1/COPS1-8 complex; membership by an SH2/SH3 signaling adaptor is biologically implausible, and this appears as a family-wide over-propagation across the GRB2/Sem-5/DRK PANTHER node. Removed on biological grounds as an over-propagated inference. Propagation Review Root cause: PROPAGATION BAD Failure modes: COMPARTMENT OR COMPLEX MISMATCH Sources checked: PANTHER:PTN005273574 Β· GRB2/Sem-5/DRK family node SUPPORTS SOURCE BUT NOT TARGET GRB2/Sem-5/DRK is an SH2/SH3 signaling adaptor family; COP9 signalosome (CSN) is a distinct GPS1/COPS1-8 complex. CSN membership does not transfer to this family. |
| GO:0008180 COP9 signalosome | IDA PMID:22561606 Tespa1 is involved in late thymocyte development through the... | UNDECIDED | Summary: IDA: asserts GRB2 is part of the COP9 signalosome (cited to a Tespa1 thymocyte-signaling paper). Reason: The cited reference concerns the T-cell-receptor signalosome, not the COP9 signalosome; its abstract does not support CSN membership and full text is not available in the cache. Cannot verify, so deferred rather than removed. Supporting Evidence: PMID:22561606 Tespa1 associated with the TCR signaling components PLC-Ξ³1 and Grb2 |
| GO:0008180 COP9 signalosome | IEA GO_REF:0000107 | REMOVE | Summary: IEA: COP9 signalosome (ortholog transfer). Reason: Electronic transfer of the implausible CSN-membership assertion (see IBA row); removed on biological grounds. |
| GO:0008286 insulin receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: IEA: involved in insulin receptor signaling pathway. Reason: GRB2 couples the insulin receptor / IRS proteins to Ras signaling; well supported. |
| GO:0008286 insulin receptor signaling pathway | IPI PMID:8388384 Insulin stimulates association of insulin receptor substrate... | ACCEPT | Summary: IPI: GRB2 (ASH) binds insulin receptor substrate 1 (IRS1), linking insulin signaling to Ras. Reason: Direct, informative interaction underpinning insulin receptor signaling. Supporting Evidence: PMID:8388384 fusion protein of ASH was able to bind the fusion protein of tyrosine-phosphorylated IRS-1 fragments, suggesting that ASH is able to bind tyrosine-phosphorylated IRS-1 directly |
| GO:0012506 vesicle membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (ortholog): vesicle membrane. Reason: Peripheral location consistent with receptor trafficking; non-core. |
| GO:0014044 Schwann cell development | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (ortholog): involved in Schwann cell development. Reason: A pleiotropic developmental process downstream of RTK signaling; not a core GRB2 molecular role. |
| GO:0016020 membrane | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (ortholog): located in membrane. Reason: Correct but general; GRB2 functions at membranes on receptor activation. |
| GO:0017124 SH3 domain binding | IDA PMID:19509291 GAREM, a novel adaptor protein for growth factor receptor-bo... | ACCEPT | Summary: IDA: GRB2 SH3-domain-mediated binding to the proline-rich motifs of GAREM/GAREM1. Reason: GRB2's two SH3 domains bind proline-rich (PxxP) ligands; GAREM is one such partner. This SH3-domain-based binding is a genuine GRB2 activity, more informative than generic protein binding. Supporting Evidence: PMID:19509291 the proline-rich motifs of GAREM are recognized by the N- and C-terminal SH3 domains of Grb2 |
| GO:0019901 protein kinase binding | IPI PMID:20086093 HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regul... | ACCEPT | Summary: IPI: protein kinase binding - GRB2 binds the tyrosine kinase ACK/TNK2. Reason: Informative interaction (kinase binding) consistent with GRB2's adaptor role at RTK complexes; more specific than generic protein binding. |
| GO:0019903 protein phosphatase binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (ortholog): protein phosphatase binding. Reason: GRB2 binds phosphatases (e.g. PTPN23) in signaling complexes; an informative binding function. |
| GO:0019904 protein domain specific binding | IEA GO_REF:0000120 | ACCEPT | Summary: IEA (ARBA/ortholog): protein domain specific binding. Reason: Captures GRB2's SH2/SH3 domain-specific binding; consistent with its adaptor architecture. |
| GO:0030036 actin cytoskeleton organization | IMP PMID:8253073 Ash/Grb-2, a SH2/SH3-containing protein, couples to signalin... | KEEP AS NON CORE | Summary: IMP: GRB2 acts upstream of/within actin cytoskeleton organization (anti-Ash antibody blocked EGF/PDGF-induced ruffling). Reason: GRB2 contributes indirectly to actin remodeling by coupling receptors to Rac signaling; a downstream/regulatory role rather than a direct core function. Supporting Evidence: PMID:8253073 The antibody abolished both S phase entry and the reorganization of actin assembly to ruffle formation upon stimulation with epidermal growth factor (EGF) and platelet-derived growth factor (PDGF). |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:25870599 GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Co... | ACCEPT | Summary: IDA: protein-macromolecule adaptor activity - GRB2 nucleates LAT signaling clusters in TCR signaling. Reason: Core GRB2 molecular function (scaffold/adaptor assembly). Its SH3-ligand binding is required to form LAT microclusters controlling PLCg1 activation and cytokine production. Supporting Evidence: PMID:25870599 GRB2 regulates signaling downstream of adaptors and receptors by both recruiting effector proteins and regulating the formation of signaling complexes. PMID:25870599 GRB2, and its ability to bind to SH3 domain ligands, is required for establishing LAT microclusters |
| GO:0030674 protein-macromolecule adaptor activity | IDA PMID:7539782 Tyrosine phosphorylation of the proto-oncogene product Vav a... | ACCEPT | Summary: IDA: protein-macromolecule adaptor activity. Reason: Core adaptor activity of GRB2, demonstrated directly. |
| GO:0030674 protein-macromolecule adaptor activity | IEA GO_REF:0000107 | ACCEPT | Summary: IEA: protein-macromolecule adaptor activity (ortholog). Reason: Correct core molecular function. |
| GO:0031623 receptor internalization | IMP PMID:14985334 Analysis of clathrin-mediated endocytosis of epidermal growt... | ACCEPT | Summary: IMP: GRB2 required for clathrin-mediated internalization of the EGF receptor. Reason: GRB2 does part of the work of receptor internalization, recruiting the endocytic/ubiquitination machinery (e.g. CBL) to activated EGFR; RNAi shows a specific requirement. A genuine, distinct GRB2 function. Supporting Evidence: PMID:14985334 CALM is the second protein besides Grb2 that appears to play a specific role in EGFR endocytosis file:human/GRB2/GRB2-deep-research-falcon.md GRB2 recruits Cbl, facilitating receptor-associated ubiquitylation and internalization |
| GO:0035022 positive regulation of Rac protein signal transduction | IC PMID:16475793 Binding of laminin alpha1-chain LG4-5 domain to alpha-dystro... | KEEP AS NON CORE | Summary: IC: positive regulation of Rac protein signal transduction (curator inference). Reason: GRB2 contributes indirectly to Rac activation downstream of receptors; a downstream regulatory effect, non-core. |
| GO:0042110 T cell activation | IDA PMID:7568038 p56Lck and p59Fyn regulate CD28 binding to phosphatidylinosi... | KEEP AS NON CORE | Summary: IDA: T cell activation (GRB2 in CD28/TCR signaling). Reason: A pleiotropic immune process in which GRB2 participates as an adaptor; non-core relative to its molecular function. |
| GO:0042267 natural killer cell mediated cytotoxicity | IDA PMID:16582911 NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 in... | KEEP AS NON CORE | Summary: IDA: natural killer cell mediated cytotoxicity - NKG2D/DAP10 signaling requires a DAP10-bound Grb2-Vav1 intermediate. Reason: GRB2 acts as an adaptor in NK activation signaling; a context-specific process, non-core. Supporting Evidence: PMID:16582911 binding of an intermediate consisting of the DAP10 binding partner Grb2 and the effector molecule Vav1 (Grb2-Vav1) to DAP10 was sufficient to initiate tyrosine-phosphorylation events |
| GO:0042552 myelination | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (ortholog): involved in myelination. Reason: A pleiotropic developmental process downstream of RTK/Ras signaling; non-core. |
| GO:0042770 signal transduction in response to DNA damage | IMP PMID:20160708 Feedback between p21 and reactive oxygen production is neces... | KEEP AS NON CORE | Summary: IMP: signal transduction in response to DNA damage (GRB2 node in a p21/ROS senescence loop). Reason: GRB2 appears as an intermediate in a GADD45-p38-GRB2-TGFBR2-TGFbeta signaling loop during senescence; an indirect, context-specific role rather than a direct DNA-damage function. Supporting Evidence: PMID:20160708 GADD45-MAPK14(p38MAPK)-GRB2-TGFBR2-TGFbeta |
| GO:0042802 identical protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | ACCEPT | Summary: IPI: identical protein binding - GRB2 homodimerization. Reason: GRB2 self-association (monomer-dimer equilibrium) is documented and functionally relevant (dimeric GRB2 regulates receptor signaling). More informative than generic protein binding. Supporting Evidence: PMID:22536782 Grb2 exists in a monomer-dimer equilibrium |
| GO:0042802 identical protein binding | IPI PMID:22536782 Bivalent binding drives the formation of the Grb2-Gab1 signa... | ACCEPT | Summary: IPI: identical protein binding - GRB2 homodimerization; dimeric GRB2 restrains basal FGFR2 signaling. Reason: Homodimerization is a real, functionally relevant GRB2 property. Supporting Evidence: PMID:22726438 Dimeric Grb2 binds to the C termini of two FGFR2 molecules. |
| GO:0042802 identical protein binding | IPI PMID:22726438 Inhibition of basal FGF receptor signaling by dimeric Grb2. | ACCEPT | Summary: IPI: identical protein binding - GRB2 homodimerization. Reason: Consistent with the documented GRB2 monomer-dimer equilibrium. |
| GO:0043408 regulation of MAPK cascade | IBA GO_REF:0000033 | ACCEPT | Summary: IBA: involved in regulation of MAPK cascade. Reason: Core process: GRB2 couples receptor activation to the RAF-MEK-ERK cascade; the phylogenetic assignment is sound. |
| GO:0043560 insulin receptor substrate binding | IPI PMID:8388384 Insulin stimulates association of insulin receptor substrate... | ACCEPT | Summary: IPI: insulin receptor substrate binding - GRB2 binds IRS1. Reason: Informative, specific binding function coupling insulin/IRS signaling to Ras. Supporting Evidence: PMID:8388384 fusion protein of ASH was able to bind the fusion protein of tyrosine-phosphorylated IRS-1 fragments, suggesting that ASH is able to bind tyrosine-phosphorylated IRS-1 directly |
| GO:0045953 negative regulation of natural killer cell mediated cytotoxicity | IDA PMID:25870599 GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Co... | KEEP AS NON CORE | Summary: IDA: negative regulation of natural killer cell mediated cytotoxicity. Reason: GRB2 is recruited by inhibitory NK receptors (e.g. TIGIT ITT-like motif, with SHIP1) to dampen cytotoxicity; a context-specific immune-regulatory role, non-core. (The seeded reference topic differs from this assertion; the function itself is documented in the GRB2 interaction literature.) |
| GO:0046875 ephrin receptor binding | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (ortholog): ephrin receptor binding. Reason: GRB2 binds activated Eph receptors (e.g. EphB1); an informative receptor-binding function. |
| GO:0046875 ephrin receptor binding | IPI PMID:12925710 EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and pro... | ACCEPT | Summary: IPI: ephrin receptor binding - GRB2 recruited by activated EphB1 (P54762). Reason: Direct, informative interaction with an Eph receptor. Supporting Evidence: PMID:12925710 activated EphB1 recruits the adaptor proteins Grb2 and p52Shc |
| GO:0048009 insulin-like growth factor receptor signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: IEA (ortholog): insulin-like growth factor receptor signaling pathway. Reason: One of many RTK pathways GRB2 feeds into; ortholog-inferred, retained as non-core. |
| GO:0050853 B cell receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: IEA (ortholog): B cell receptor signaling pathway. Reason: GRB2 (with GRAP) couples the B-cell antigen receptor to Erk/MAPK activation; well supported in the literature. |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: HDA: extracellular exosome (proteomic identification). Reason: High-throughput proteomic detection in exosomes; not a functional site for GRB2's adaptor activity. Retained as non-core. |
| GO:0070062 extracellular exosome | HDA PMID:20458337 MHC class II-associated proteins in B-cell exosomes and pote... | KEEP AS NON CORE | Summary: HDA: extracellular exosome (proteomic identification). Reason: High-throughput proteomic detection; non-core location. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: HDA: extracellular exosome (proteomic identification). Reason: High-throughput proteomic detection; non-core location. |
| GO:0070436 Grb2-EGFR complex | IDA PMID:20086093 HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regul... | ACCEPT | Summary: IDA: part of the Grb2-EGFR complex. Reason: The GRB2-EGFR complex is the canonical GRB2-containing receptor complex; directly observed. Consistent with core EGFR-Ras signaling. |
| GO:0071479 cellular response to ionizing radiation | IMP PMID:20160708 Feedback between p21 and reactive oxygen production is neces... | KEEP AS NON CORE | Summary: IMP: cellular response to ionizing radiation (p21/ROS senescence loop). Reason: Indirect, context-specific role as a node in a senescence signaling loop; non-core. Supporting Evidence: PMID:20160708 GADD45-MAPK14(p38MAPK)-GRB2-TGFBR2-TGFbeta |
| GO:2000379 positive regulation of reactive oxygen species metabolic process | IMP PMID:20160708 Feedback between p21 and reactive oxygen production is neces... | KEEP AS NON CORE | Summary: IMP: positive regulation of reactive oxygen species metabolic process (senescence signaling loop). Reason: GRB2 is an intermediate in a GADD45-p38-GRB2-TGFBR2-TGFbeta loop that ultimately drives ROS in senescence; GRB2 does not itself perform ROS metabolism, so this is an indirect, non-core effect. Supporting Evidence: PMID:20160708 GADD45-MAPK14(p38MAPK)-GRB2-TGFBR2-TGFbeta |
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Download this section (compressed HTML)Q: Should the many specific GRB2 receptor/partner interactions annotated only as protein binding be systematically captured under phosphotyrosine residue binding, SH3/proline-rich binding, or adaptor activity rather than removed?
Q: Is the COP9 signalosome (GO:0008180) annotation to GRB2 supportable in any organism, or is it a family-wide over-propagation that should be retired?
Q: Does GRB2 RNA binding (interactome capture) reflect a bona fide, functionally relevant activity connected to its reported nuclear microRNA-regulatory role?
Experiment: Domain-resolved separation-of-function mutants (SH2-dead vs N-SH3 vs C-SH3) with endogenous tagging to map which core GRB2 activities (phosphotyrosine binding, SOS/Ras coupling, LAT cluster formation, receptor internalization) each interaction supports.
Hypothesis: Distinct GRB2 domains support separable core functions that current gene-level annotations conflate.
Experiment: Reconstituted membrane assays quantifying GRB2 monomer-dimer equilibrium effects on SOS recruitment versus basal receptor (e.g. FGFR2) restraint.
Hypothesis: GRB2 dimerization switches its role between promoting and restraining receptor signaling.
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