GRXCR2 supports hearing and stereocilia organization. Mouse studies associate it with basal taperin restriction. A human recessive variant causes hearing loss; GRXCR2’s biochemical activity remains unresolved. It lacks a canonical glutaredoxin domain.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0005902 microvillus | IBA GO_REF:0000033 | KEEP AS NON CORE | Reason: The verified AN1 activity-location inheritance is retained. Human CL4 targeting is compatible; it does not directly assay microvillar activity or an endogenous human pool. |
| GO:0005902 microvillus | IEA GO_REF:0000107 | KEEP AS NON CORE | Reason: Mouse orthology transfers microvillar location. The paper reports unshown mouse CL4 data; direct human targeting supports retention as non-core. Supporting Evidence: |
| GO:0005902 microvillus | IMP PMID:24619944 A frameshift mutation in GRXCR2 causes recessively inherited... | KEEP AS NON CORE | Reason: Myc-tagged human GRXCR2 targets actin-rich microvilli in porcine CL4 cells. This positive experimental pool is non-core. Supporting Evidence: PMID:24619944 selective localization of GRXCR2wt to microvilli |
| GO:0007605 sensory perception of sound | IBA GO_REF:0000033 | ACCEPT | Reason: The target inherits AN1/PTN000807801 with exact human/mouse IBD donors. GRXCR2-dependent stereocilia organization supports auditory perception. |
| GO:0007605 sensory perception of sound | IEA GO_REF:0000002 | ACCEPT | Reason: The GRXCR2-specific IPR033023 mapping agrees with human hearing-loss genetics. Supporting Evidence: |
| GO:0007605 sensory perception of sound | IMP PMID:24619944 A frameshift mutation in GRXCR2 causes recessively inherited... | ACCEPT | Reason: Human recessive hearing loss supports the existing acts_upstream_of_or_within assertion; no channel activity is established. Supporting Evidence: |
| GO:0032420 stereocilium | IEA GO_REF:0000044 | TOO GENERAL | Reason: Stereocilium base is part_of stereocilium; the accepted base location supplies positive, more specific coverage. Supporting Evidence: file:human/GRXCR2/GRXCR2-source-evidence.json |
| GO:0120043 stereocilium shaft | IBA GO_REF:0000033 | KEEP AS NON CORE | Reason: The verified AN1 inference retains an adult shaft pool; its separate physiological role remains unresolved. |
| GO:0120043 stereocilium shaft | IEA GO_REF:0000107 | KEEP AS NON CORE | Reason: Adult mouse staining supports this secondary shaft pool, retained as non-core. Supporting Evidence: |
| GO:0120044 stereocilium base | IBA GO_REF:0000033 | ACCEPT | Reason: AN1 inheritance and mouse basal taperin restriction support this activity location. |
| GO:0120044 stereocilium base | IEA GO_REF:0000107 | ACCEPT | Reason: Endogenous mouse staining supports the transferred basal location. Supporting Evidence: |
| GO:0060122 inner ear receptor cell stereocilium organization | ISS PMID:30380417 GRXCR2 Regulates Taperin Localization Critical for Stereocil... | NEW | Reason: Infer human involvement from mouse Q3TYR5: GRXCR2 restricts taperin spatially, and reducing taperin rescues mutant bundle morphology. Supporting Evidence: PMID:30380417 reducing taperin expression rescued stereocilia morphology file:human/GRXCR2/GRXCR2-source-evidence.json |
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Download this section (compressed HTML)Q: What biochemical interaction retains taperin at the base of human stereocilia?
Experiment: Measure purified human GRXCR2–taperin affinity and compare interaction-region mutants.
Hypothesis: Direct binding contributes to taperin confinement.
Type: Biochemical reconstitution
What is not known — curated, literature-grounded statements of the open unknowns (the inverse of core functions).
Gap: Direct GRXCR2–taperin binding and the organizing mechanism remain unresolved.
OPEN BIOLOGY
What is known: Mouse co-immunoprecipitation establishes association.
Provenance (the field's own admissions):
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