GSK3B encodes glycogen synthase kinase-3 beta, a constitutively active, ATP-dependent serine/threonine protein kinase regulated by inhibitory Ser-9 and activating Tyr-216 phosphorylation. GSK3B phosphorylates primed and unprimed protein substrates across glucose/glycogen metabolism, canonical Wnt/beta-catenin signaling, transcription-factor regulation, protein ubiquitination/degradation, autophagy, apoptosis, neuronal polarity, microtubule regulation, and tau biology. Core disease-relevant functions include tau-protein kinase activity that reduces tau microtubule binding, negative regulation of canonical Wnt signaling through the beta-catenin destruction complex, and insulin-linked negative control of glycogen synthesis.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0030424 axon | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: axon is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030424 (axon), the IBA annotation with qualifier is_active_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030425 dendrite | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: dendrite is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030425 (dendrite), the IBA annotation with qualifier is_active_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | IBA GO_REF:0000033 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030154 cell differentiation | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030154 (cell differentiation), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0050321 tau-protein kinase activity | IBA GO_REF:0000033 | ACCEPT | Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0032007 negative regulation of TOR signaling | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: negative regulation of TOR signaling is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032007 (negative regulation of TOR signaling), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010508 positive regulation of autophagy | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: positive regulation of autophagy is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010508 (positive regulation of autophagy), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043525 positive regulation of neuron apoptotic process | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: positive regulation of neuron apoptotic process is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043525 (positive regulation of neuron apoptotic process), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IBA GO_REF:0000033 | ACCEPT | Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0070507 regulation of microtubule cytoskeleton organization | IBA GO_REF:0000033 | ACCEPT | Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010975 regulation of neuron projection development | IBA GO_REF:0000033 | ACCEPT | Summary: regulation of neuron projection development is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010975 (regulation of neuron projection development), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0098978 glutamatergic synapse | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IBA annotation with qualifier is_active_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0008286 insulin receptor signaling pathway | IBA GO_REF:0000033 | ACCEPT | Summary: insulin receptor signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008286 (insulin receptor signaling pathway), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008013 beta-catenin binding | IBA GO_REF:0000033 | ACCEPT | Summary: beta-catenin binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008013 (beta-catenin binding), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030877 beta-catenin destruction complex | IBA GO_REF:0000033 | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IBA annotation with qualifier part_of from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004672 protein kinase activity | IEA GO_REF:0000120 | MODIFY | Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0004674 protein serine/threonine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005524 ATP binding | IEA GO_REF:0000002 | ACCEPT | Summary: ATP binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005524 (ATP binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IEA annotation with qualifier located_in from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | IEA GO_REF:0000044 | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0009968 negative regulation of signal transduction | IEA GO_REF:0000117 | MARK AS OVER ANNOTATED | Summary: negative regulation of signal transduction is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0009968 (negative regulation of signal transduction), the IEA annotation with qualifier involved_in from GO_REF:0000117 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0019082 viral protein processing | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019082 (viral protein processing), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0031398 positive regulation of protein ubiquitination | IEA GO_REF:0000117 | ACCEPT | Summary: positive regulation of protein ubiquitination is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031398 (positive regulation of protein ubiquitination), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IEA GO_REF:0000117 | ACCEPT | Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034236 protein kinase A catalytic subunit binding | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: protein kinase A catalytic subunit binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034236 (protein kinase A catalytic subunit binding), the IEA annotation with qualifier enables from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0050321 tau-protein kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0098793 presynapse | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: presynapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098793 (presynapse), the IEA annotation with qualifier located_in from GO_REF:0000108 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:2000077 negative regulation of type B pancreatic cell development | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: negative regulation of type B pancreatic cell development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000077 (negative regulation of type B pancreatic cell development), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:10481074 A GSK3-binding peptide from FRAT1 selectively inhibits the G... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:10481074 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:11004522 Cloning and characterization of a novel human ninein protein... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:11004522 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:11035810 Phosphorylation and inactivation of glycogen synthase kinase... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:11035810 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:11738041 The structure of phosphorylated GSK-3beta complexed with a p... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:11738041 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:12421363 Axin negatively affects tau phosphorylation by glycogen synt... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:12421363 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:12434148 Crystal structure of an activated Akt/protein kinase B terna... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:12434148 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:14744935 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:15147888 A novel ninein-interaction protein, CGI-99, blocks ninein ph... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15147888 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:15752768 Characterization of two non-testis-specific CABYR variants t... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15752768 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:16282323 Evidence that Ser87 of BimEL is phosphorylated by Akt and re... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16282323 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:16365045 The low density lipoprotein receptor-related protein 6 inter... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16365045 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:16890161 Caveolin is necessary for Wnt-3a-dependent internalization o... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16890161 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17078951 PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17078951 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17139249 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17317006 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylatio... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17317006 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17318191 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17510365 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:17601533 Two functionally distinct Axin-like proteins regulate canoni... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17601533 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:18045539 Integrating patterning signals: Wnt/GSK3 regulates the durat... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18045539 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:18505846 p53 stabilization in response to DNA damage requires Akt/PKB... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18505846 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:18687691 Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by i... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18687691 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19131971 The Axin1 scaffold protein promotes formation of a degradati... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19131971 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19202075 Beta-arrestin links endothelin A receptor to beta-catenin si... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19202075 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19249679 Oncogenic function of ATDC in pancreatic cancer through Wnt ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19249679 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19303846 Disrupted in schizophrenia 1 regulates neuronal progenitor p... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19303846 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19411070 Stabilization of snail by NF-kappaB is required for inflamma... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19411070 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:19759537 Tankyrase inhibition stabilizes axin and antagonizes Wnt sig... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19759537 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20080667 Role of DAB2IP in modulating epithelial-to-mesenchymal trans... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20080667 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20368287 Interactome mapping of the phosphatidylinositol 3-kinase-mam... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20368287 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20389281 The SNAG domain of Snail1 functions as a molecular hook for ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20389281 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:20856200 Vimentin is a novel AKT1 target mediating motility and invas... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20856200 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21118991 The EDD E3 ubiquitin ligase ubiquitinates and up-regulates b... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21118991 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21217772 Glycogen synthase kinase-3Ξ² is a crucial mediator of signal-... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21217772 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21242974 Methylation by protein arginine methyltransferase 1 increase... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21242974 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21743491 Microsomal prostaglandin E synthase-1 promotes hepatocarcino... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21743491 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21900206 A directed protein interaction network for investigating int... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21900206 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21985244 Stimulatory effect of Ξ±-synuclein on the tau-phosphorylation... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21985244 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21988832 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:22470507 Oncogenic function of DACT1 in colon cancer through the regu... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22470507 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:22682247 Wnt signaling through inhibition of Ξ²-catenin degradation in... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22682247 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:22699938 Kindlin 2 forms a transcriptional complex with Ξ²-catenin and... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22699938 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:22773187 Dual functions of DP1 promote biphasic Wnt-on and Wnt-off st... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22773187 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:23010592 NOK/STYK1 interacts with GSK-3Ξ² and mediates Ser9 phosphoryl... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23010592 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:23455922 Interlaboratory reproducibility of large-scale human protein... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23455922 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:23602568 The protein interaction landscape of the human CMGC kinase g... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23602568 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:24165324 Leucine-rich repeat kinaseΒ 2 regulates tau phosphorylation t... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24165324 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:24879152 Phosphorylation of NBR1 by GSK3 modulates protein aggregatio... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24879152 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:24976009 YAP/TAZ incorporation in the Ξ²-catenin destruction complex o... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24976009 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25241761 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26496610 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:26618561 Direct High Affinity Interaction between AΞ²42 and GSK3Ξ± Stim... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26618561 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:27601169 Vitamin D receptor is a novel transcriptional regulator for ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:27601169 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:29568061 An AP-MS- and BioID-compatible MAC-tag enables comprehensive... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:29568061 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:31640277 GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:31640277 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:32707033 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:33248025 Phosphoregulation of Phase Separation by the SARS-CoV-2Β N Pr... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33248025 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33961781 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:34232536 Interactomes of SARS-CoV-2 and human coronaviruses reveal ho... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:34232536 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:35063084 Tau interactome maps synaptic and mitochondrial processes as... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:35063084 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:35271311 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:35512704 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:8638126 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005829 cytosol | IEA GO_REF:0000107 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the IEA annotation with qualifier located_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0007127 meiosis I | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: meiosis I is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007127 (meiosis I), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0007623 circadian rhythm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007623 (circadian rhythm), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0008013 beta-catenin binding | IEA GO_REF:0000107 | ACCEPT | Summary: beta-catenin binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008013 (beta-catenin binding), the IEA annotation with qualifier enables from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008286 insulin receptor signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: insulin receptor signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008286 (insulin receptor signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010508 positive regulation of autophagy | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of autophagy is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010508 (positive regulation of autophagy), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010628 positive regulation of gene expression | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010954 positive regulation of protein processing | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010954 (positive regulation of protein processing), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0014069 postsynaptic density | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: postsynaptic density is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0014069 (postsynaptic density), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0019901 protein kinase binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019901 (protein kinase binding), the IEA annotation with qualifier enables from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030426 growth cone | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: growth cone is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030426 (growth cone), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030877 beta-catenin destruction complex | IEA GO_REF:0000120 | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IEA annotation with qualifier part_of from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031663 lipopolysaccharide-mediated signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: lipopolysaccharide-mediated signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031663 (lipopolysaccharide-mediated signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032007 negative regulation of TOR signaling | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of TOR signaling is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032007 (negative regulation of TOR signaling), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032481 positive regulation of type I interferon production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of type I interferon production is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032481 (positive regulation of type I interferon production), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032886 regulation of microtubule-based process | IEA GO_REF:0000107 | ACCEPT | Summary: regulation of microtubule-based process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032886 (regulation of microtubule-based process), the IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0036016 cellular response to interleukin-3 | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to interleukin-3 is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0036016 (cellular response to interleukin-3), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0042752 regulation of circadian rhythm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0042752 (regulation of circadian rhythm), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0042981 regulation of apoptotic process | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of apoptotic process is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0042981 (regulation of apoptotic process), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043025 neuronal cell body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: neuronal cell body is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043025 (neuronal cell body), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043198 dendritic shaft | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: dendritic shaft is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043198 (dendritic shaft), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043491 (phosphatidylinositol 3-kinase/protein kinase B signal transduction), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0044297 cell body | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cell body is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0044297 (cell body), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0045719 negative regulation of glycogen biosynthetic process | IEA GO_REF:0000120 | ACCEPT | Summary: negative regulation of glycogen biosynthetic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045719 (negative regulation of glycogen biosynthetic process), the IEA annotation with qualifier involved_in from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045724 positive regulation of cilium assembly | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of cilium assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045724 (positive regulation of cilium assembly), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0045879 negative regulation of smoothened signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of smoothened signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045879 (negative regulation of smoothened signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0048471 perinuclear region of cytoplasm | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: perinuclear region of cytoplasm is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0048471 (perinuclear region of cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0070840 dynein complex binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: dynein complex binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070840 (dynein complex binding), the IEA annotation with qualifier enables from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0071385 cellular response to glucocorticoid stimulus | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: cellular response to glucocorticoid stimulus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0071385 (cellular response to glucocorticoid stimulus), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0072687 meiotic spindle | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: meiotic spindle is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0072687 (meiotic spindle), the IEA annotation with qualifier is_active_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097191 extrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: extrinsic apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097191 (extrinsic apoptotic signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: extrinsic apoptotic signaling pathway in absence of ligand is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0098978 glutamatergic synapse | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IEA annotation with qualifier is_active_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0106310 protein serine kinase activity | IEA GO_REF:0000120 | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1900026 positive regulation of substrate adhesion-dependent cell spreading | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of substrate adhesion-dependent cell spreading is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1900271 regulation of long-term synaptic potentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: regulation of long-term synaptic potentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900271 (regulation of long-term synaptic potentiation), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1903566 positive regulation of protein localization to cilium | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of protein localization to cilium is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1903566 (positive regulation of protein localization to cilium), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1904780 negative regulation of protein localization to centrosome | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: negative regulation of protein localization to centrosome is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904780 (negative regulation of protein localization to centrosome), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1990904 ribonucleoprotein complex | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ribonucleoprotein complex is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1990904 (ribonucleoprotein complex), the IEA annotation with qualifier part_of from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1990909 Wnt signalosome | IEA GO_REF:0000107 | ACCEPT | Summary: Wnt signalosome is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1990909 (Wnt signalosome), the IEA annotation with qualifier part_of from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:2000727 positive regulation of cardiac muscle cell differentiation | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: positive regulation of cardiac muscle cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000727 (positive regulation of cardiac muscle cell differentiation), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:40274799 TTC36 promotes proliferation and drug resistance in hepatoce... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:40274799 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0060070 canonical Wnt signaling pathway | TAS Reactome:R-HSA-4641262 | ACCEPT | Summary: canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060070 (canonical Wnt signaling pathway), the TAS annotation with qualifier involved_in from Reactome:R-HSA-4641262 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1900034 regulation of cellular response to heat | TAS Reactome:R-HSA-3371453 | KEEP AS NON CORE | Summary: regulation of cellular response to heat is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900034 (regulation of cellular response to heat), the TAS annotation with qualifier involved_in from Reactome:R-HSA-3371453 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-195283 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-195283 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-195287 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-195287 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-195300 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-195300 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-201677 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-201677 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-3371435 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-3371435 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-399951 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-399951 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-5610732 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-5610732 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9683664 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9683664 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9729260 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9729260 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9762094 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9762094 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9824995 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9824995 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9824999 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9824999 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9929360 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9929360 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-HSA-9943675 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9943675 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-NUL-209146 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-NUL-209146 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | TAS Reactome:R-NUL-9008636 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-NUL-9008636 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005634 nucleus | IDA PMID:12223487 The regulation of glycogen synthase kinase-3 nuclear export ... | ACCEPT | Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from PMID:12223487 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IDA PMID:12223487 The regulation of glycogen synthase kinase-3 nuclear export ... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:12223487 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030877 beta-catenin destruction complex | NAS PMID:9601641 Downregulation of beta-catenin by human Axin and its associa... | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the NAS annotation with qualifier part_of from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process | NAS PMID:9601641 Downregulation of beta-catenin by human Axin and its associa... | ACCEPT | Summary: proteasome-mediated ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), the NAS annotation with qualifier involved_in from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0046825 regulation of protein export from nucleus | IDA PMID:12223487 The regulation of glycogen synthase kinase-3 nuclear export ... | KEEP AS NON CORE | Summary: regulation of protein export from nucleus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0046825 (regulation of protein export from nucleus), the IDA annotation with qualifier involved_in from PMID:12223487 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:10428961 Axin and Frat1 interact with dvl and GSK, bridging Dvl to GS... | ACCEPT | Summary: canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060070 (canonical Wnt signaling pathway), the IDA annotation with qualifier involved_in from PMID:10428961 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004672 protein kinase activity | IMP PMID:25733715 GSK3- and PRMT-1-dependent modifications of desmoplakin cont... | MODIFY | Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the IMP annotation with qualifier enables from PMID:25733715 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0032880 regulation of protein localization | IMP PMID:25733715 GSK3- and PRMT-1-dependent modifications of desmoplakin cont... | MARK AS OVER ANNOTATED | Summary: regulation of protein localization is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032880 (regulation of protein localization), the IMP annotation with qualifier involved_in from PMID:25733715 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:16705181 Multisite protein kinase A and glycogen synthase kinase 3bet... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:16705181 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045879 negative regulation of smoothened signaling pathway | IDA PMID:16705181 Multisite protein kinase A and glycogen synthase kinase 3bet... | KEEP AS NON CORE | Summary: negative regulation of smoothened signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045879 (negative regulation of smoothened signaling pathway), the IDA annotation with qualifier involved_in from PMID:16705181 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the IDA annotation with qualifier located_in from GO_REF:0000052 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005634 nucleus | EXP PMID:21029237 Modulation of tau phosphorylation by the kinase PKR: implica... | ACCEPT | Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the EXP annotation with qualifier located_in from PMID:21029237 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | EXP PMID:21029237 Modulation of tau phosphorylation by the kinase PKR: implica... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:21029237 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | EXP PMID:25169422 HN1 negatively influences the Ξ²-catenin/E-cadherin interacti... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:25169422 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | EXP PMID:25733715 GSK3- and PRMT-1-dependent modifications of desmoplakin cont... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:25733715 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | EXP PMID:35606353 GSK3Ξ² palmitoylation mediated by ZDHHC4 promotes tumorigenic... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:35606353 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:17050006 Glycogen synthase kinase-3beta binds to E2F1 and regulates i... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:17050006 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:17681942 Regulation of human cytidine triphosphate synthetase 1 by gl... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:17681942 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3Ξ²-m... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:21343617 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:22539723 GSK3-TIP60-ULK1 signaling pathway links growth factor depriv... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:22539723 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:25827072 FBXO11 promotes ubiquitination of the Snail family of transc... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:25827072 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:28992046 Phosphorylated E2F1 is stabilized by nuclear USP11 to drive ... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:28992046 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0106310 protein serine kinase activity | EXP PMID:29059170 SPSB3 targets SNAIL for degradation in GSK-3Ξ² phosphorylatio... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:29059170 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0032481 positive regulation of type I interferon production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of type I interferon production is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032481 (positive regulation of type I interferon production), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0160213 beta-arrestin-dependent dopamine receptor signaling pathway | NAS PMID:21711983 A role for Akt and glycogen synthase kinase-3 as integrators... | KEEP AS NON CORE | Summary: beta-arrestin-dependent dopamine receptor signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0160213 (beta-arrestin-dependent dopamine receptor signaling pathway), the NAS annotation with qualifier involved_in from PMID:21711983 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0019082 viral protein processing | TAS Reactome:R-HSA-9683610 | KEEP AS NON CORE | Summary: viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019082 (viral protein processing), the TAS annotation with qualifier involved_in from Reactome:R-HSA-9683610 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0003170 heart valve development | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: heart valve development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0003170 (heart valve development), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:25897075 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:25897075 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016055 Wnt signaling pathway | IMP PMID:18156211 Regulation of endothelial cell cytoskeletal reorganization b... | ACCEPT | Summary: Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0016055 (Wnt signaling pathway), the IMP annotation with qualifier involved_in from PMID:18156211 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m... | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IMP annotation with qualifier involved_in from PMID:24023731 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005788 endoplasmic reticulum lumen | TAS Reactome:R-HSA-9929360 | KEEP AS NON CORE | Summary: endoplasmic reticulum lumen is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005788 (endoplasmic reticulum lumen), the TAS annotation with qualifier located_in from Reactome:R-HSA-9929360 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030877 beta-catenin destruction complex | IDA PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:18593713 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097110 scaffold protein binding | IPI PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ... | KEEP AS NON CORE | Summary: scaffold protein binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097110 (scaffold protein binding), the IPI annotation with qualifier enables from PMID:18593713 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0034976 response to endoplasmic reticulum stress | IDA PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3Ξ²-m... | KEEP AS NON CORE | Summary: response to endoplasmic reticulum stress is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034976 (response to endoplasmic reticulum stress), the IDA annotation with qualifier involved_in from PMID:21343617 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3Ξ²-m... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:21343617 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1903940 negative regulation of TORC2 signaling | IDA PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3Ξ²-m... | KEEP AS NON CORE | Summary: negative regulation of TORC2 signaling is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1903940 (negative regulation of TORC2 signaling), the IDA annotation with qualifier involved_in from PMID:21343617 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:25827072 FBXO11 promotes ubiquitination of the Snail family of transc... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:25827072 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:29059170 SPSB3 targets SNAIL for degradation in GSK-3Ξ² phosphorylatio... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:29059170 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010719 negative regulation of epithelial to mesenchymal transition | IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | KEEP AS NON CORE | Summary: negative regulation of epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010719 (negative regulation of epithelial to mesenchymal transition), the IDA annotation with qualifier involved_in from PMID:15448698 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010719 negative regulation of epithelial to mesenchymal transition | IDA PMID:25827072 FBXO11 promotes ubiquitination of the Snail family of transc... | KEEP AS NON CORE | Summary: negative regulation of epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010719 (negative regulation of epithelial to mesenchymal transition), the IDA annotation with qualifier involved_in from PMID:25827072 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010719 negative regulation of epithelial to mesenchymal transition | IDA PMID:29059170 SPSB3 targets SNAIL for degradation in GSK-3Ξ² phosphorylatio... | KEEP AS NON CORE | Summary: negative regulation of epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010719 (negative regulation of epithelial to mesenchymal transition), the IDA annotation with qualifier involved_in from PMID:29059170 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:34058472 A catenin of the plakophilin-subfamily, Pkp3, responds to ca... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:34058472 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0098978 glutamatergic synapse | EXP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ... | KEEP AS NON CORE | Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the EXP annotation with qualifier is_active_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0098978 glutamatergic synapse | IDA PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ... | KEEP AS NON CORE | Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IDA annotation with qualifier is_active_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0098978 glutamatergic synapse | IMP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ... | KEEP AS NON CORE | Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IMP annotation with qualifier is_active_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | EXP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the EXP annotation with qualifier involved_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | IDA PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the IDA annotation with qualifier involved_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0099171 presynaptic modulation of chemical synaptic transmission | IMP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ... | KEEP AS NON CORE | Summary: presynaptic modulation of chemical synaptic transmission is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the IMP annotation with qualifier involved_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0007005 mitochondrion organization | IMP PMID:25118933 The protease Omi regulates mitochondrial biogenesis through ... | KEEP AS NON CORE | Summary: mitochondrion organization is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007005 (mitochondrion organization), the IMP annotation with qualifier involved_in from PMID:25118933 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030336 negative regulation of cell migration | IDA PMID:27494834 GSK3Ξ² inactivation promotes the oncogenic functions of EZH2 ... | KEEP AS NON CORE | Summary: negative regulation of cell migration is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030336 (negative regulation of cell migration), the IDA annotation with qualifier involved_in from PMID:27494834 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0060070 canonical Wnt signaling pathway | IDA PMID:16890161 Caveolin is necessary for Wnt-3a-dependent internalization o... | ACCEPT | Summary: canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060070 (canonical Wnt signaling pathway), the IDA annotation with qualifier involved_in from PMID:16890161 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045668 negative regulation of osteoblast differentiation | IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m... | KEEP AS NON CORE | Summary: negative regulation of osteoblast differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045668 (negative regulation of osteoblast differentiation), the IMP annotation with qualifier involved_in from PMID:24023731 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA PMID:22660580 F-box protein FBXL19-mediated ubiquitination and degradation... | ACCEPT | Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IDA annotation with qualifier involved_in from PMID:22660580 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0019082 viral protein processing | TAS Reactome:R-HSA-9694631 | KEEP AS NON CORE | Summary: viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019082 (viral protein processing), the TAS annotation with qualifier involved_in from Reactome:R-HSA-9694631 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:29142209 Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis ... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:29142209 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031398 positive regulation of protein ubiquitination | IDA PMID:29142209 Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis ... | ACCEPT | Summary: positive regulation of protein ubiquitination is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031398 (positive regulation of protein ubiquitination), the IDA annotation with qualifier involved_in from PMID:29142209 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0097191 extrinsic apoptotic signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: extrinsic apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097191 (extrinsic apoptotic signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010628 positive regulation of gene expression | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:28992046 Phosphorylated E2F1 is stabilized by nuclear USP11 to drive ... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:28992046 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045724 positive regulation of cilium assembly | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of cilium assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045724 (positive regulation of cilium assembly), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1903566 positive regulation of protein localization to cilium | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of protein localization to cilium is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1903566 (positive regulation of protein localization to cilium), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0106310 protein serine kinase activity | IGI PMID:30556160 miR-219-5p inhibits tau phosphorylation by targeting TTBK1 a... | ACCEPT | Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the IGI annotation with qualifier enables from PMID:30556160 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010628 positive regulation of gene expression | IMP PMID:26315788 miRNA-99b-3p functions as a potential tumor suppressor by ta... | KEEP AS NON CORE | Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:26315788 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010628 positive regulation of gene expression | IMP PMID:27050373 The role of glycogen synthase kinase-3Ξ² (GSK-3Ξ²) in endometr... | KEEP AS NON CORE | Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:27050373 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010629 negative regulation of gene expression | IMP PMID:27050373 The role of glycogen synthase kinase-3Ξ² (GSK-3Ξ²) in endometr... | KEEP AS NON CORE | Summary: negative regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010629 (negative regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:27050373 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IGI PMID:27846906 Upregulation of miR-501-5p activates the wnt/Ξ²-catenin signa... | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IGI annotation with qualifier involved_in from PMID:27846906 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0010629 negative regulation of gene expression | IMP PMID:28122350 Transcriptional suppression of microRNA-27a contributes to l... | KEEP AS NON CORE | Summary: negative regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010629 (negative regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:28122350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0045597 positive regulation of cell differentiation | IMP PMID:28122350 Transcriptional suppression of microRNA-27a contributes to l... | KEEP AS NON CORE | Summary: positive regulation of cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045597 (positive regulation of cell differentiation), the IMP annotation with qualifier involved_in from PMID:28122350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0071300 cellular response to retinoic acid | IMP PMID:28122350 Transcriptional suppression of microRNA-27a contributes to l... | KEEP AS NON CORE | Summary: cellular response to retinoic acid is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0071300 (cellular response to retinoic acid), the IMP annotation with qualifier involved_in from PMID:28122350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:2000740 negative regulation of mesenchymal stem cell differentiation | IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m... | KEEP AS NON CORE | Summary: negative regulation of mesenchymal stem cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000740 (negative regulation of mesenchymal stem cell differentiation), the IMP annotation with qualifier involved_in from PMID:24023731 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:19364825 Identification of domains responsible for ubiquitin-dependen... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:19364825 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IDA PMID:19364825 Identification of domains responsible for ubiquitin-dependen... | ACCEPT | Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IDA annotation with qualifier involved_in from PMID:19364825 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:18846110 Identification of an antiapoptotic protein complex at death ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18846110 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | IMP PMID:18846110 Identification of an antiapoptotic protein complex at death ... | KEEP AS NON CORE | Summary: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors), the IMP annotation with qualifier involved_in from PMID:18846110 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:31073040 LMBR1L regulates lymphopoiesis through Wnt/Ξ²-catenin signali... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:31073040 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0150101 regulation of microtubule anchoring at centrosome | IMP PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol... | KEEP AS NON CORE | Summary: regulation of microtubule anchoring at centrosome is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0150101 (regulation of microtubule anchoring at centrosome), the IMP annotation with qualifier involved_in from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0010508 positive regulation of autophagy | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of autophagy is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010508 (positive regulation of autophagy), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0042752 regulation of circadian rhythm | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0042752 (regulation of circadian rhythm), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1900271 regulation of long-term synaptic potentiation | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of long-term synaptic potentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900271 (regulation of long-term synaptic potentiation), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0106027 neuron projection organization | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: neuron projection organization is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106027 (neuron projection organization), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:28903391 Cancer/testis antigen PIWIL2 suppresses circadian rhythms by... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28903391 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0048156 tau protein binding | NAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: tau protein binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0048156 (tau protein binding), the NAS annotation with qualifier enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0050321 tau-protein kinase activity | NAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the NAS annotation with qualifier enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IC PMID:9601641 Downregulation of beta-catenin by human Axin and its associa... | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IC annotation with qualifier involved_in from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004672 protein kinase activity | IMP PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ... | MODIFY | Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the IMP annotation with qualifier enables from PMID:16981698 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0004674 protein serine/threonine kinase activity | IMP PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IMP annotation with qualifier enables from PMID:16981698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16981698 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0006468 protein phosphorylation | IMP PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ... | ACCEPT | Summary: protein phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0006468 (protein phosphorylation), the IMP annotation with qualifier involved_in from PMID:16981698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:28829046 Twa1/Gid8 is a Ξ²-catenin nuclear retention factor in Wnt sig... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28829046 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0030010 establishment of cell polarity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: establishment of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030010 (establishment of cell polarity), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030010 establishment of cell polarity | TAS PMID:18268107 Microtubule stabilization specifies initial neuronal polariz... | KEEP AS NON CORE | Summary: establishment of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030010 (establishment of cell polarity), the TAS annotation with qualifier involved_in from PMID:18268107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030011 maintenance of cell polarity | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: maintenance of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030011 (maintenance of cell polarity), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030011 maintenance of cell polarity | TAS PMID:18268107 Microtubule stabilization specifies initial neuronal polariz... | KEEP AS NON CORE | Summary: maintenance of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030011 (maintenance of cell polarity), the TAS annotation with qualifier involved_in from PMID:18268107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030424 axon | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: axon is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030424 (axon), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030425 dendrite | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: dendrite is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030425 (dendrite), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030516 regulation of axon extension | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of axon extension is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030516 (regulation of axon extension), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0048814 regulation of dendrite morphogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of dendrite morphogenesis is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0048814 (regulation of dendrite morphogenesis), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0050770 regulation of axonogenesis | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: regulation of axonogenesis is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050770 (regulation of axonogenesis), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0070507 regulation of microtubule cytoskeleton organization | ISS GO_REF:0000024 | ACCEPT | Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | NAS PMID:28386764 Roles of tau protein in health and disease. | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the NAS annotation with qualifier enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0060079 excitatory postsynaptic potential | NAS PMID:21711983 A role for Akt and glycogen synthase kinase-3 as integrators... | KEEP AS NON CORE | Summary: excitatory postsynaptic potential is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060079 (excitatory postsynaptic potential), the NAS annotation with qualifier involved_in from PMID:21711983 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:25897075 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25897075 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IMP PMID:25897075 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent... | ACCEPT | Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IMP annotation with qualifier involved_in from PMID:25897075 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:17139249 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034452 dynactin binding | IPI PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol... | KEEP AS NON CORE | Summary: dynactin binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034452 (dynactin binding), the IPI annotation with qualifier enables from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1904781 positive regulation of protein localization to centrosome | IMP PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol... | KEEP AS NON CORE | Summary: positive regulation of protein localization to centrosome is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904781 (positive regulation of protein localization to centrosome), the IMP annotation with qualifier involved_in from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005813 centrosome | IDA PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol... | KEEP AS NON CORE | Summary: centrosome is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005813 (centrosome), the IDA annotation with qualifier located_in from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | NAS PMID:8725894 Glycogen synthase kinase 3 alpha and 3 beta do not colocaliz... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the NAS annotation with qualifier enables from PMID:8725894 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1904646 cellular response to amyloid-beta | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: cellular response to amyloid-beta is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904646 (cellular response to amyloid-beta), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:20007971 Glycogen synthase kinase 3beta interaction protein functions... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20007971 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0031175 neuron projection development | IDA PMID:19830702 GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/bet... | ACCEPT | Summary: neuron projection development is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031175 (neuron projection development), the IDA annotation with qualifier involved_in from PMID:19830702 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:25920809 GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25920809 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:27484798 The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kina... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:27484798 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0002020 protease binding | IPI PMID:25118933 The protease Omi regulates mitochondrial biogenesis through ... | KEEP AS NON CORE | Summary: protease binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0002020 (protease binding), the IPI annotation with qualifier enables from PMID:25118933 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004672 protein kinase activity | TAS PMID:26049140 A WNT1-regulated developmental gene cascade prevents dopamin... | MODIFY | Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the TAS annotation with qualifier enables from PMID:26049140 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0035556 intracellular signal transduction | TAS PMID:26049140 A WNT1-regulated developmental gene cascade prevents dopamin... | MARK AS OVER ANNOTATED | Summary: intracellular signal transduction is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0035556 (intracellular signal transduction), the TAS annotation with qualifier involved_in from PMID:26049140 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:1904339 negative regulation of dopaminergic neuron differentiation | TAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an... | KEEP AS NON CORE | Summary: negative regulation of dopaminergic neuron differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904339 (negative regulation of dopaminergic neuron differentiation), the TAS annotation with qualifier involved_in from PMID:24431302 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004672 protein kinase activity | TAS PMID:22988876 The importance of Wnt signalling for neurodegeneration in Pa... | MODIFY | Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the TAS annotation with qualifier enables from PMID:22988876 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0004672 protein kinase activity | TAS PMID:24115276 The regulation and deregulation of Wnt signaling by PARK gen... | MODIFY | Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the TAS annotation with qualifier enables from PMID:24115276 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:1990909 Wnt signalosome | TAS PMID:24115276 The regulation and deregulation of Wnt signaling by PARK gen... | ACCEPT | Summary: Wnt signalosome is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1990909 (Wnt signalosome), the TAS annotation with qualifier part_of from PMID:24115276 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030877 beta-catenin destruction complex | TAS PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua... | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the TAS annotation with qualifier part_of from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process | IC PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua... | ACCEPT | Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IC annotation with qualifier involved_in from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | IC PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua... | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IC annotation with qualifier involved_in from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:16315267 GSK3B polymorphisms alter transcription and splicing in Park... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:16315267 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9762094 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9762094 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9824995 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9824995 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9824999 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9824999 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9943675 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9943675 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005654 nucleoplasm | TAS Reactome:R-NUL-9008555 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-NUL-9008555 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005654 nucleoplasm | TAS Reactome:R-NUL-9008636 | ACCEPT | Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-NUL-9008636 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:1900181 negative regulation of protein localization to nucleus | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: negative regulation of protein localization to nucleus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900181 (negative regulation of protein localization to nucleus), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:24391509 NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolve... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24391509 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0016301 kinase activity | IDA PMID:24391509 NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolve... | MODIFY | Summary: kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0016301 (kinase activity), the IDA annotation with qualifier enables from PMID:24391509 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0005515 protein binding | IPI PMID:19706605 GSK-3 phosphorylates delta-catenin and negatively regulates ... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19706605 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0046777 protein autophosphorylation | IDA PMID:23184662 Phosphorylation of eukaryotic elongation factor 2 (eEF2) by ... | ACCEPT | Summary: protein autophosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0046777 (protein autophosphorylation), the IDA annotation with qualifier involved_in from PMID:23184662 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5339713 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5339713 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0036016 cellular response to interleukin-3 | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: cellular response to interleukin-3 is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0036016 (cellular response to interleukin-3), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: extrinsic apoptotic signaling pathway in absence of ligand is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2399966 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2399966 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-1504186 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-1504186 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195251 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195251 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195275 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195275 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195280 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195280 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195283 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195283 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195287 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195287 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195300 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195300 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195304 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195304 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-195318 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195318 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-201677 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-201677 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-201685 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-201685 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130279 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2130279 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130282 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2130282 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-2130286 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2130286 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-3371435 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-3371435 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-399951 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-399951 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4791278 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4791278 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4827388 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4827388 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4839634 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839634 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4839635 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839635 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4839638 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839638 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4839734 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839734 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-4839746 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839746 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5229343 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5229343 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5323526 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5323526 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5368596 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5368596 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5610732 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5610732 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9683664 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9683664 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9687724 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9687724 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9729260 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9729260 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-1458902 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-1458902 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005829 cytosol | TAS Reactome:R-NUL-209146 | ACCEPT | Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-209146 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0007623 circadian rhythm | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007623 (circadian rhythm), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0032092 positive regulation of protein binding | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: positive regulation of protein binding is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032092 (positive regulation of protein binding), the ISS annotation with qualifier involved_in from GO_REF:0000024 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:9072970 Nuclear export of NF-ATc enhanced by glycogen synthase kinas... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:9072970 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030877 beta-catenin destruction complex | TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake. | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the TAS annotation with qualifier part_of from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045719 negative regulation of glycogen biosynthetic process | TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake. | ACCEPT | Summary: negative regulation of glycogen biosynthetic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045719 (negative regulation of glycogen biosynthetic process), the TAS annotation with qualifier involved_in from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0050321 tau-protein kinase activity | IDA PMID:14690523 Primed phosphorylation of tau at Thr231 by glycogen synthase... | ACCEPT | Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IDA annotation with qualifier enables from PMID:14690523 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0070885 negative regulation of calcineurin-NFAT signaling cascade | IMP PMID:9072970 Nuclear export of NF-ATc enhanced by glycogen synthase kinas... | KEEP AS NON CORE | Summary: negative regulation of calcineurin-NFAT signaling cascade is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070885 (negative regulation of calcineurin-NFAT signaling cascade), the IMP annotation with qualifier involved_in from PMID:9072970 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0090090 negative regulation of canonical Wnt signaling pathway | TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake. | ACCEPT | Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the TAS annotation with qualifier involved_in from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:2000077 negative regulation of type B pancreatic cell development | TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake. | KEEP AS NON CORE | Summary: negative regulation of type B pancreatic cell development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000077 (negative regulation of type B pancreatic cell development), the TAS annotation with qualifier involved_in from PMID:19366350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:2000466 negative regulation of glycogen (starch) synthase activity | TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake. | ACCEPT | Summary: negative regulation of glycogen (starch) synthase activity is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000466 (negative regulation of glycogen (starch) synthase activity), the TAS annotation with qualifier involved_in from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:18348280 Importance of autophosphorylation at Ser186 in the A-loop of... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:18348280 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0019901 protein kinase binding | IPI PMID:18348280 Importance of autophosphorylation at Ser186 in the A-loop of... | KEEP AS NON CORE | Summary: protein kinase binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:18348280 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005813 centrosome | IDA PMID:21399614 Novel asymmetrically localizing components of human centroso... | KEEP AS NON CORE | Summary: centrosome is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005813 (centrosome), the IDA annotation with qualifier located_in from PMID:21399614 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005737 cytoplasm | IDA PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005886 plasma membrane | IDA PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC... | ACCEPT | Summary: plasma membrane is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006468 protein phosphorylation | IDA PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC... | ACCEPT | Summary: protein phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0006468 (protein phosphorylation), the IDA annotation with qualifier involved_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0032886 regulation of microtubule-based process | IMP PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC... | ACCEPT | Summary: regulation of microtubule-based process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032886 (regulation of microtubule-based process), the IMP annotation with qualifier involved_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:9731200 Human dynamin-like protein interacts with the glycogen synth... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9731200 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:20864106 PTEN differentially regulates expressions of ICAM-1 and VCAM... | KEEP AS NON CORE | Summary: RNA polymerase II-specific DNA-binding transcription factor binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), the IPI annotation with qualifier enables from PMID:20864106 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0031625 ubiquitin protein ligase binding | IPI PMID:21118991 The EDD E3 ubiquitin ligase ubiquitinates and up-regulates b... | KEEP AS NON CORE | Summary: ubiquitin protein ligase binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031625 (ubiquitin protein ligase binding), the IPI annotation with qualifier enables from PMID:21118991 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0002039 p53 binding | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | KEEP AS NON CORE | Summary: p53 binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0002039 (p53 binding), the IDA annotation with qualifier enables from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005634 nucleus | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0006983 ER overload response | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | KEEP AS NON CORE | Summary: ER overload response is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0006983 (ER overload response), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0018105 peptidyl-serine phosphorylation | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | ACCEPT | Summary: peptidyl-serine phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0018105 (peptidyl-serine phosphorylation), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0043066 negative regulation of apoptotic process | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | KEEP AS NON CORE | Summary: negative regulation of apoptotic process is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043066 (negative regulation of apoptotic process), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0046827 positive regulation of protein export from nucleus | IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz... | KEEP AS NON CORE | Summary: positive regulation of protein export from nucleus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0046827 (positive regulation of protein export from nucleus), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0001837 epithelial to mesenchymal transition | IMP PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | KEEP AS NON CORE | Summary: epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0001837 (epithelial to mesenchymal transition), the IMP annotation with qualifier involved_in from PMID:15448698 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005515 protein binding | IPI PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15448698 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005634 nucleus | IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | ACCEPT | Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0016301 kinase activity | IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati... | MODIFY | Summary: kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0016301 (kinase activity), the IDA annotation with qualifier enables from PMID:15448698 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity |
| GO:0050321 tau-protein kinase activity | IDA PMID:16365045 The low density lipoprotein receptor-related protein 6 inter... | ACCEPT | Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IDA annotation with qualifier enables from PMID:16365045 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031333 negative regulation of protein-containing complex assembly | IMP PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d... | KEEP AS NON CORE | Summary: negative regulation of protein-containing complex assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031333 (negative regulation of protein-containing complex assembly), the IMP annotation with qualifier involved_in from PMID:16188939 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0005737 cytoplasm | IDA PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:19038973 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0021766 hippocampus development | IMP PMID:19581563 Association of GSK3beta polymorphisms with brain structural ... | KEEP AS NON CORE | Summary: hippocampus development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0021766 (hippocampus development), the IMP annotation with qualifier involved_in from PMID:19581563 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0071109 superior temporal gyrus development | IMP PMID:19581563 Association of GSK3beta polymorphisms with brain structural ... | KEEP AS NON CORE | Summary: superior temporal gyrus development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0071109 (superior temporal gyrus development), the IMP annotation with qualifier involved_in from PMID:19581563 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0001954 positive regulation of cell-matrix adhesion | IMP PMID:18156211 Regulation of endothelial cell cytoskeletal reorganization b... | KEEP AS NON CORE | Summary: positive regulation of cell-matrix adhesion is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0001954 (positive regulation of cell-matrix adhesion), the IMP annotation with qualifier involved_in from PMID:18156211 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0030877 beta-catenin destruction complex | IDA PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d... | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:16188939 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0045732 positive regulation of protein catabolic process | IC PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d... | ACCEPT | Summary: positive regulation of protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045732 (positive regulation of protein catabolic process), the IC annotation with qualifier involved_in from PMID:16188939 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005737 cytoplasm | IDA PMID:18787224 Constitutive activation of the Wnt canonical pathway in mant... | ACCEPT | Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:18787224 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:11035810 Phosphorylation and inactivation of glycogen synthase kinase... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:11035810 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0034236 protein kinase A catalytic subunit binding | IPI PMID:11035810 Phosphorylation and inactivation of glycogen synthase kinase... | KEEP AS NON CORE | Summary: protein kinase A catalytic subunit binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034236 (protein kinase A catalytic subunit binding), the IPI annotation with qualifier enables from PMID:11035810 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005977 glycogen metabolic process | IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | ACCEPT | Summary: glycogen metabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005977 (glycogen metabolic process), the IDA annotation with qualifier involved_in from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0008013 beta-catenin binding | IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | ACCEPT | Summary: beta-catenin binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008013 (beta-catenin binding), the IPI annotation with qualifier enables from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0030877 beta-catenin destruction complex | IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0031334 positive regulation of protein-containing complex assembly | IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu... | KEEP AS NON CORE | Summary: positive regulation of protein-containing complex assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031334 (positive regulation of protein-containing complex assembly), the IDA annotation with qualifier involved_in from PMID:8638126 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
| GO:0004674 protein serine/threonine kinase activity | ISS GO_REF:0000024 | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the ISS annotation with qualifier enables from GO_REF:0000024 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:9482734 Axin, a negative regulator of the Wnt signaling pathway, for... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9482734 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0004674 protein serine/threonine kinase activity | IDA PMID:11104755 Substitution of a glycogen synthase kinase-3beta phosphoryla... | ACCEPT | Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:11104755 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0018105 peptidyl-serine phosphorylation | IDA PMID:11104755 Substitution of a glycogen synthase kinase-3beta phosphoryla... | ACCEPT | Summary: peptidyl-serine phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0018105 (peptidyl-serine phosphorylation), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:11104755 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0035556 intracellular signal transduction | IDA PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ... | MARK AS OVER ANNOTATED | Summary: intracellular signal transduction is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0035556 (intracellular signal transduction), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14749367 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0005515 protein binding | IPI PMID:9601641 Downregulation of beta-catenin by human Axin and its associa... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9601641 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0030877 beta-catenin destruction complex | IDA PMID:9601641 Downregulation of beta-catenin by human Axin and its associa... | ACCEPT | Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label. |
| GO:0005515 protein binding | IPI PMID:12927815 Molecular characterization of human ninein protein: two dist... | MARK AS OVER ANNOTATED | Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:12927815 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function. |
| GO:0051059 NF-kappaB binding | IPI PMID:15465828 Phosphorylation of serine 468 by GSK-3beta negatively regula... | KEEP AS NON CORE | Summary: NF-kappaB binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0051059 (NF-kappaB binding), the IPI annotation with qualifier enables from PMID:15465828 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function. |
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Download this section (compressed HTML)Q: Which GSK3B pathway annotations should be treated as central kinase/substrate biology versus pleiotropic downstream effects of a broadly connected kinase?
Q: For Alzheimer disease, should GSK3B curation emphasize tau phosphorylation and microtubule regulation, Wnt/beta-catenin signaling, insulin/glycogen metabolism, synaptic signaling, or all as separate non-equivalent branches?
Q: Which generic high-throughput protein-interaction annotations can be replaced by reproducible endogenous substrate, scaffold, or regulator-specific GO terms?
Experiment: Use endogenous GSK3B perturbation and phosphosite-specific rescue in human iPSC-derived neurons and glia, measuring tau phosphorylation/microtubule binding, beta-catenin degradation, glycogen/insulin signaling, synaptic phenotypes, and cell viability under amyloid or inflammatory stress.
Hypothesis: Alzheimer-relevant GSK3B effects depend on separable tau-phosphorylation and Wnt/beta-catenin substrate pools rather than global kinase abundance alone.
Type: substrate-resolved kinase perturbation assay
Experiment: Perform quantitative phosphoproteomics after acute GSK3B inhibition or analog-sensitive GSK3B mutation, then classify direct phosphosites by priming dependence and map them to tau, CTNNB1, GYS1, RICTOR, SNAI1, NFAT, and other candidate substrate pathways.
Hypothesis: Primed-substrate docking determines which GSK3B GO pathway outputs are direct functions versus secondary pathway consequences.
Type: acute kinase-substrate phosphoproteomics
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