GSK3B

Existing Annotations Review

GO Term	Evidence	Action	Reason
GO:0030424 axon	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: axon is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030424 (axon), the IBA annotation with qualifier is_active_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030425 dendrite	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: dendrite is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030425 (dendrite), the IBA annotation with qualifier is_active_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005634 nucleus	IBA GO_REF:0000033	ACCEPT	Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	IBA GO_REF:0000033	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	IBA GO_REF:0000033	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the IBA annotation with qualifier is_active_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030154 cell differentiation	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030154 (cell differentiation), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0050321 tau-protein kinase activity	IBA GO_REF:0000033	ACCEPT	Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0090090 negative regulation of canonical Wnt signaling pathway	IBA GO_REF:0000033	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0032007 negative regulation of TOR signaling	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: negative regulation of TOR signaling is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032007 (negative regulation of TOR signaling), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010508 positive regulation of autophagy	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: positive regulation of autophagy is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010508 (positive regulation of autophagy), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0043525 positive regulation of neuron apoptotic process	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: positive regulation of neuron apoptotic process is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043525 (positive regulation of neuron apoptotic process), the IBA annotation with qualifier involved_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IBA GO_REF:0000033	ACCEPT	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0070507 regulation of microtubule cytoskeleton organization	IBA GO_REF:0000033	ACCEPT	Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0010975 regulation of neuron projection development	IBA GO_REF:0000033	ACCEPT	Summary: regulation of neuron projection development is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010975 (regulation of neuron projection development), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0098978 glutamatergic synapse	IBA GO_REF:0000033	KEEP AS NON CORE	Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IBA annotation with qualifier is_active_in from GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0008286 insulin receptor signaling pathway	IBA GO_REF:0000033	ACCEPT	Summary: insulin receptor signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008286 (insulin receptor signaling pathway), the IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0008013 beta-catenin binding	IBA GO_REF:0000033	ACCEPT	Summary: beta-catenin binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008013 (beta-catenin binding), the IBA annotation with qualifier enables from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030877 beta-catenin destruction complex	IBA GO_REF:0000033	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IBA annotation with qualifier part_of from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004672 protein kinase activity	IEA GO_REF:0000120	MODIFY	Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0004674 protein serine/threonine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005524 ATP binding	IEA GO_REF:0000002	ACCEPT	Summary: ATP binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005524 (ATP binding), the IEA annotation with qualifier enables from GO_REF:0000002 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005634 nucleus	IEA GO_REF:0000120	ACCEPT	Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IEA annotation with qualifier located_in from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	IEA GO_REF:0000044	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane	IEA GO_REF:0000044	ACCEPT	Summary: plasma membrane is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in from GO_REF:0000044 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0009968 negative regulation of signal transduction	IEA GO_REF:0000117	MARK AS OVER ANNOTATED	Summary: negative regulation of signal transduction is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0009968 (negative regulation of signal transduction), the IEA annotation with qualifier involved_in from GO_REF:0000117 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0019082 viral protein processing	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019082 (viral protein processing), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0031398 positive regulation of protein ubiquitination	IEA GO_REF:0000117	ACCEPT	Summary: positive regulation of protein ubiquitination is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031398 (positive regulation of protein ubiquitination), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA GO_REF:0000117	ACCEPT	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0034236 protein kinase A catalytic subunit binding	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: protein kinase A catalytic subunit binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034236 (protein kinase A catalytic subunit binding), the IEA annotation with qualifier enables from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0050321 tau-protein kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0098793 presynapse	IEA GO_REF:0000108	KEEP AS NON CORE	Summary: presynapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098793 (presynapse), the IEA annotation with qualifier located_in from GO_REF:0000108 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:2000077 negative regulation of type B pancreatic cell development	IEA GO_REF:0000117	KEEP AS NON CORE	Summary: negative regulation of type B pancreatic cell development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000077 (negative regulation of type B pancreatic cell development), the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:10481074 A GSK3-binding peptide from FRAT1 selectively inhibits the G...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:10481074 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:11004522 Cloning and characterization of a novel human ninein protein...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:11004522 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:11035810 Phosphorylation and inactivation of glycogen synthase kinase...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:11035810 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:11738041 The structure of phosphorylated GSK-3beta complexed with a p...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:11738041 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:12421363 Axin negatively affects tau phosphorylation by glycogen synt...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:12421363 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:12434148 Crystal structure of an activated Akt/protein kinase B terna...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:12434148 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:14744935 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:15147888 A novel ninein-interaction protein, CGI-99, blocks ninein ph...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15147888 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:15752768 Characterization of two non-testis-specific CABYR variants t...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15752768 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:16282323 Evidence that Ser87 of BimEL is phosphorylated by Akt and re...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16282323 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:16365045 The low density lipoprotein receptor-related protein 6 inter...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16365045 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:16890161 Caveolin is necessary for Wnt-3a-dependent internalization o...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16890161 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:17078951 PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17078951 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17139249 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:17317006 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylatio...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17317006 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:17318191 Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17318191 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:17510365 Wilms tumor suppressor WTX negatively regulates WNT/beta-cat...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17510365 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:17601533 Two functionally distinct Axin-like proteins regulate canoni...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:17601533 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:18045539 Integrating patterning signals: Wnt/GSK3 regulates the durat...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18045539 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:18505846 p53 stabilization in response to DNA damage requires Akt/PKB...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18505846 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:18687691 Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by i...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18687691 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:19131971 The Axin1 scaffold protein promotes formation of a degradati...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19131971 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:19202075 Beta-arrestin links endothelin A receptor to beta-catenin si...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19202075 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:19249679 Oncogenic function of ATDC in pancreatic cancer through Wnt ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19249679 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:19303846 Disrupted in schizophrenia 1 regulates neuronal progenitor p...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19303846 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:19411070 Stabilization of snail by NF-kappaB is required for inflamma...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19411070 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:19759537 Tankyrase inhibition stabilizes axin and antagonizes Wnt sig...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19759537 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:20080667 Role of DAB2IP in modulating epithelial-to-mesenchymal trans...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20080667 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:20368287 Interactome mapping of the phosphatidylinositol 3-kinase-mam...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20368287 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:20389281 The SNAG domain of Snail1 functions as a molecular hook for ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20389281 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:20856200 Vimentin is a novel AKT1 target mediating motility and invas...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20856200 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21118991 The EDD E3 ubiquitin ligase ubiquitinates and up-regulates b...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21118991 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21217772 Glycogen synthase kinase-3β is a crucial mediator of signal-...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21217772 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21242974 Methylation by protein arginine methyltransferase 1 increase...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21242974 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21743491 Microsomal prostaglandin E synthase-1 promotes hepatocarcino...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21743491 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21900206 A directed protein interaction network for investigating int...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21900206 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21985244 Stimulatory effect of α-synuclein on the tau-phosphorylation...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21985244 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:21988832 Toward an understanding of the protein interaction network o...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:21988832 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:22470507 Oncogenic function of DACT1 in colon cancer through the regu...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22470507 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:22682247 Wnt signaling through inhibition of β-catenin degradation in...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22682247 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:22699938 Kindlin 2 forms a transcriptional complex with β-catenin and...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22699938 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:22773187 Dual functions of DP1 promote biphasic Wnt-on and Wnt-off st...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:22773187 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:23010592 NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphoryl...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23010592 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:23455922 Interlaboratory reproducibility of large-scale human protein...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23455922 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:23602568 The protein interaction landscape of the human CMGC kinase g...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:23602568 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:24165324 Leucine-rich repeat kinase 2 regulates tau phosphorylation t...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24165324 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:24879152 Phosphorylation of NBR1 by GSK3 modulates protein aggregatio...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24879152 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:24976009 YAP/TAZ incorporation in the β-catenin destruction complex o...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24976009 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25241761 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:26496610 A human interactome in three quantitative dimensions organiz...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26496610 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:26618561 Direct High Affinity Interaction between Aβ42 and GSK3α Stim...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:26618561 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:27601169 Vitamin D receptor is a novel transcriptional regulator for ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:27601169 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:29568061 An AP-MS- and BioID-compatible MAC-tag enables comprehensive...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:29568061 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:31640277 GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:31640277 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:32707033 Kinase Interaction Network Expands Functional and Disease Ro...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:32707033 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:33248025 Phosphoregulation of Phase Separation by the SARS-CoV-2 N Pr...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33248025 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:33961781 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:34232536 Interactomes of SARS-CoV-2 and human coronaviruses reveal ho...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:34232536 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:35063084 Tau interactome maps synaptic and mitochondrial processes as...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:35063084 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:35271311 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:35512704 Systematic discovery of mutation-directed neo-protein-protei...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:35512704 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:8638126 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005829 cytosol	IEA GO_REF:0000107	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the IEA annotation with qualifier located_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0007127 meiosis I	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: meiosis I is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007127 (meiosis I), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0007623 circadian rhythm	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007623 (circadian rhythm), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0008013 beta-catenin binding	IEA GO_REF:0000107	ACCEPT	Summary: beta-catenin binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008013 (beta-catenin binding), the IEA annotation with qualifier enables from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0008286 insulin receptor signaling pathway	IEA GO_REF:0000107	ACCEPT	Summary: insulin receptor signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008286 (insulin receptor signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0010508 positive regulation of autophagy	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of autophagy is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010508 (positive regulation of autophagy), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010628 positive regulation of gene expression	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010954 positive regulation of protein processing	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010954 (positive regulation of protein processing), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0014069 postsynaptic density	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: postsynaptic density is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0014069 (postsynaptic density), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0019901 protein kinase binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: protein kinase binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019901 (protein kinase binding), the IEA annotation with qualifier enables from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030426 growth cone	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: growth cone is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030426 (growth cone), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030877 beta-catenin destruction complex	IEA GO_REF:0000120	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IEA annotation with qualifier part_of from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0031663 lipopolysaccharide-mediated signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: lipopolysaccharide-mediated signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031663 (lipopolysaccharide-mediated signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032007 negative regulation of TOR signaling	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of TOR signaling is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032007 (negative regulation of TOR signaling), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032481 positive regulation of type I interferon production	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of type I interferon production is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032481 (positive regulation of type I interferon production), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032886 regulation of microtubule-based process	IEA GO_REF:0000107	ACCEPT	Summary: regulation of microtubule-based process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032886 (regulation of microtubule-based process), the IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0036016 cellular response to interleukin-3	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to interleukin-3 is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0036016 (cellular response to interleukin-3), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0042752 regulation of circadian rhythm	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: regulation of circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0042752 (regulation of circadian rhythm), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0042981 regulation of apoptotic process	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: regulation of apoptotic process is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0042981 (regulation of apoptotic process), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0043025 neuronal cell body	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: neuronal cell body is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043025 (neuronal cell body), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0043198 dendritic shaft	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: dendritic shaft is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043198 (dendritic shaft), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: phosphatidylinositol 3-kinase/protein kinase B signal transduction is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043491 (phosphatidylinositol 3-kinase/protein kinase B signal transduction), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0044297 cell body	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cell body is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0044297 (cell body), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0045719 negative regulation of glycogen biosynthetic process	IEA GO_REF:0000120	ACCEPT	Summary: negative regulation of glycogen biosynthetic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045719 (negative regulation of glycogen biosynthetic process), the IEA annotation with qualifier involved_in from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045724 positive regulation of cilium assembly	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of cilium assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045724 (positive regulation of cilium assembly), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0045879 negative regulation of smoothened signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of smoothened signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045879 (negative regulation of smoothened signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0048471 perinuclear region of cytoplasm	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: perinuclear region of cytoplasm is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0048471 (perinuclear region of cytoplasm), the IEA annotation with qualifier located_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0070840 dynein complex binding	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: dynein complex binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070840 (dynein complex binding), the IEA annotation with qualifier enables from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0071385 cellular response to glucocorticoid stimulus	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: cellular response to glucocorticoid stimulus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0071385 (cellular response to glucocorticoid stimulus), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0072687 meiotic spindle	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: meiotic spindle is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0072687 (meiotic spindle), the IEA annotation with qualifier is_active_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0090090 negative regulation of canonical Wnt signaling pathway	IEA GO_REF:0000107	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0097191 extrinsic apoptotic signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: extrinsic apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097191 (extrinsic apoptotic signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: extrinsic apoptotic signaling pathway in absence of ligand is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0098978 glutamatergic synapse	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IEA annotation with qualifier is_active_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0106310 protein serine kinase activity	IEA GO_REF:0000120	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the IEA annotation with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of substrate adhesion-dependent cell spreading is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1900271 regulation of long-term synaptic potentiation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: regulation of long-term synaptic potentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900271 (regulation of long-term synaptic potentiation), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1903566 positive regulation of protein localization to cilium	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of protein localization to cilium is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1903566 (positive regulation of protein localization to cilium), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1904780 negative regulation of protein localization to centrosome	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: negative regulation of protein localization to centrosome is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904780 (negative regulation of protein localization to centrosome), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1990904 ribonucleoprotein complex	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: ribonucleoprotein complex is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1990904 (ribonucleoprotein complex), the IEA annotation with qualifier part_of from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1990909 Wnt signalosome	IEA GO_REF:0000107	ACCEPT	Summary: Wnt signalosome is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1990909 (Wnt signalosome), the IEA annotation with qualifier part_of from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:2000727 positive regulation of cardiac muscle cell differentiation	IEA GO_REF:0000107	KEEP AS NON CORE	Summary: positive regulation of cardiac muscle cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000727 (positive regulation of cardiac muscle cell differentiation), the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:40274799 TTC36 promotes proliferation and drug resistance in hepatoce...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:40274799 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0060070 canonical Wnt signaling pathway	TAS Reactome:R-HSA-4641262	ACCEPT	Summary: canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060070 (canonical Wnt signaling pathway), the TAS annotation with qualifier involved_in from Reactome:R-HSA-4641262 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1900034 regulation of cellular response to heat	TAS Reactome:R-HSA-3371453	KEEP AS NON CORE	Summary: regulation of cellular response to heat is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900034 (regulation of cellular response to heat), the TAS annotation with qualifier involved_in from Reactome:R-HSA-3371453 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-195283	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-195283 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-195287	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-195287 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-195300	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-195300 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-201677	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-201677 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-3371435	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-3371435 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-399951	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-399951 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-5610732	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-5610732 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9683664	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9683664 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9729260	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9729260 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9762094	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9762094 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9824995	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9824995 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9824999	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9824999 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9929360	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9929360 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-HSA-9943675	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-HSA-9943675 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-NUL-209146	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-NUL-209146 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	TAS Reactome:R-NUL-9008636	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation with qualifier enables from Reactome:R-NUL-9008636 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005634 nucleus	IDA PMID:12223487 The regulation of glycogen synthase kinase-3 nuclear export ...	ACCEPT	Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from PMID:12223487 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	IDA PMID:12223487 The regulation of glycogen synthase kinase-3 nuclear export ...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:12223487 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030877 beta-catenin destruction complex	NAS PMID:9601641 Downregulation of beta-catenin by human Axin and its associa...	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the NAS annotation with qualifier part_of from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process	NAS PMID:9601641 Downregulation of beta-catenin by human Axin and its associa...	ACCEPT	Summary: proteasome-mediated ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process), the NAS annotation with qualifier involved_in from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0046825 regulation of protein export from nucleus	IDA PMID:12223487 The regulation of glycogen synthase kinase-3 nuclear export ...	KEEP AS NON CORE	Summary: regulation of protein export from nucleus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0046825 (regulation of protein export from nucleus), the IDA annotation with qualifier involved_in from PMID:12223487 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0060070 canonical Wnt signaling pathway	IDA PMID:10428961 Axin and Frat1 interact with dvl and GSK, bridging Dvl to GS...	ACCEPT	Summary: canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060070 (canonical Wnt signaling pathway), the IDA annotation with qualifier involved_in from PMID:10428961 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004672 protein kinase activity	IMP PMID:25733715 GSK3- and PRMT-1-dependent modifications of desmoplakin cont...	MODIFY	Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the IMP annotation with qualifier enables from PMID:25733715 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0032880 regulation of protein localization	IMP PMID:25733715 GSK3- and PRMT-1-dependent modifications of desmoplakin cont...	MARK AS OVER ANNOTATED	Summary: regulation of protein localization is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032880 (regulation of protein localization), the IMP annotation with qualifier involved_in from PMID:25733715 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:16705181 Multisite protein kinase A and glycogen synthase kinase 3bet...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:16705181 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045879 negative regulation of smoothened signaling pathway	IDA PMID:16705181 Multisite protein kinase A and glycogen synthase kinase 3bet...	KEEP AS NON CORE	Summary: negative regulation of smoothened signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045879 (negative regulation of smoothened signaling pathway), the IDA annotation with qualifier involved_in from PMID:16705181 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005654 nucleoplasm	IDA GO_REF:0000052	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the IDA annotation with qualifier located_in from GO_REF:0000052 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005634 nucleus	EXP PMID:21029237 Modulation of tau phosphorylation by the kinase PKR: implica...	ACCEPT	Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the EXP annotation with qualifier located_in from PMID:21029237 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	EXP PMID:21029237 Modulation of tau phosphorylation by the kinase PKR: implica...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:21029237 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	EXP PMID:25169422 HN1 negatively influences the β-catenin/E-cadherin interacti...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:25169422 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	EXP PMID:25733715 GSK3- and PRMT-1-dependent modifications of desmoplakin cont...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:25733715 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	EXP PMID:35606353 GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenic...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from PMID:35606353 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:17050006 Glycogen synthase kinase-3beta binds to E2F1 and regulates i...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:17050006 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:17681942 Regulation of human cytidine triphosphate synthetase 1 by gl...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:17681942 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3β-m...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:21343617 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:22539723 GSK3-TIP60-ULK1 signaling pathway links growth factor depriv...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:22539723 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:25827072 FBXO11 promotes ubiquitination of the Snail family of transc...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:25827072 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:28992046 Phosphorylated E2F1 is stabilized by nuclear USP11 to drive ...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:28992046 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0106310 protein serine kinase activity	EXP PMID:29059170 SPSB3 targets SNAIL for degradation in GSK-3β phosphorylatio...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier enables from PMID:29059170 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0032481 positive regulation of type I interferon production	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of type I interferon production is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032481 (positive regulation of type I interferon production), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0160213 beta-arrestin-dependent dopamine receptor signaling pathway	NAS PMID:21711983 A role for Akt and glycogen synthase kinase-3 as integrators...	KEEP AS NON CORE	Summary: beta-arrestin-dependent dopamine receptor signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0160213 (beta-arrestin-dependent dopamine receptor signaling pathway), the NAS annotation with qualifier involved_in from PMID:21711983 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0019082 viral protein processing	TAS Reactome:R-HSA-9683610	KEEP AS NON CORE	Summary: viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019082 (viral protein processing), the TAS annotation with qualifier involved_in from Reactome:R-HSA-9683610 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0003170 heart valve development	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: heart valve development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0003170 (heart valve development), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:25897075 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:25897075 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016055 Wnt signaling pathway	IMP PMID:18156211 Regulation of endothelial cell cytoskeletal reorganization b...	ACCEPT	Summary: Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0016055 (Wnt signaling pathway), the IMP annotation with qualifier involved_in from PMID:18156211 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0090090 negative regulation of canonical Wnt signaling pathway	IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m...	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IMP annotation with qualifier involved_in from PMID:24023731 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005788 endoplasmic reticulum lumen	TAS Reactome:R-HSA-9929360	KEEP AS NON CORE	Summary: endoplasmic reticulum lumen is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005788 (endoplasmic reticulum lumen), the TAS annotation with qualifier located_in from Reactome:R-HSA-9929360 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030877 beta-catenin destruction complex	IDA PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ...	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:18593713 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0097110 scaffold protein binding	IPI PMID:18593713 Smad7 stabilizes beta-catenin binding to E-cadherin complex ...	KEEP AS NON CORE	Summary: scaffold protein binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097110 (scaffold protein binding), the IPI annotation with qualifier enables from PMID:18593713 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0034976 response to endoplasmic reticulum stress	IDA PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3β-m...	KEEP AS NON CORE	Summary: response to endoplasmic reticulum stress is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034976 (response to endoplasmic reticulum stress), the IDA annotation with qualifier involved_in from PMID:21343617 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3β-m...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:21343617 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1903940 negative regulation of TORC2 signaling	IDA PMID:21343617 ER stress inhibits mTORC2 and Akt signaling through GSK-3β-m...	KEEP AS NON CORE	Summary: negative regulation of TORC2 signaling is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1903940 (negative regulation of TORC2 signaling), the IDA annotation with qualifier involved_in from PMID:21343617 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:25827072 FBXO11 promotes ubiquitination of the Snail family of transc...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:25827072 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:29059170 SPSB3 targets SNAIL for degradation in GSK-3β phosphorylatio...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:29059170 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0010719 negative regulation of epithelial to mesenchymal transition	IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	KEEP AS NON CORE	Summary: negative regulation of epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010719 (negative regulation of epithelial to mesenchymal transition), the IDA annotation with qualifier involved_in from PMID:15448698 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010719 negative regulation of epithelial to mesenchymal transition	IDA PMID:25827072 FBXO11 promotes ubiquitination of the Snail family of transc...	KEEP AS NON CORE	Summary: negative regulation of epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010719 (negative regulation of epithelial to mesenchymal transition), the IDA annotation with qualifier involved_in from PMID:25827072 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010719 negative regulation of epithelial to mesenchymal transition	IDA PMID:29059170 SPSB3 targets SNAIL for degradation in GSK-3β phosphorylatio...	KEEP AS NON CORE	Summary: negative regulation of epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010719 (negative regulation of epithelial to mesenchymal transition), the IDA annotation with qualifier involved_in from PMID:29059170 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:34058472 A catenin of the plakophilin-subfamily, Pkp3, responds to ca...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:34058472 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0098978 glutamatergic synapse	EXP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ...	KEEP AS NON CORE	Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the EXP annotation with qualifier is_active_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0098978 glutamatergic synapse	IDA PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ...	KEEP AS NON CORE	Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IDA annotation with qualifier is_active_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0098978 glutamatergic synapse	IMP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ...	KEEP AS NON CORE	Summary: glutamatergic synapse is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0098978 (glutamatergic synapse), the IMP annotation with qualifier is_active_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0099171 presynaptic modulation of chemical synaptic transmission	EXP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ...	KEEP AS NON CORE	Summary: presynaptic modulation of chemical synaptic transmission is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the EXP annotation with qualifier involved_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0099171 presynaptic modulation of chemical synaptic transmission	IDA PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ...	KEEP AS NON CORE	Summary: presynaptic modulation of chemical synaptic transmission is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the IDA annotation with qualifier involved_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0099171 presynaptic modulation of chemical synaptic transmission	IMP PMID:17989287 Activation of glycogen synthase kinase-3 inhibits long-term ...	KEEP AS NON CORE	Summary: presynaptic modulation of chemical synaptic transmission is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the IMP annotation with qualifier involved_in from PMID:17989287 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0007005 mitochondrion organization	IMP PMID:25118933 The protease Omi regulates mitochondrial biogenesis through ...	KEEP AS NON CORE	Summary: mitochondrion organization is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007005 (mitochondrion organization), the IMP annotation with qualifier involved_in from PMID:25118933 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030336 negative regulation of cell migration	IDA PMID:27494834 GSK3β inactivation promotes the oncogenic functions of EZH2 ...	KEEP AS NON CORE	Summary: negative regulation of cell migration is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030336 (negative regulation of cell migration), the IDA annotation with qualifier involved_in from PMID:27494834 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0060070 canonical Wnt signaling pathway	IDA PMID:16890161 Caveolin is necessary for Wnt-3a-dependent internalization o...	ACCEPT	Summary: canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060070 (canonical Wnt signaling pathway), the IDA annotation with qualifier involved_in from PMID:16890161 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045668 negative regulation of osteoblast differentiation	IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m...	KEEP AS NON CORE	Summary: negative regulation of osteoblast differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045668 (negative regulation of osteoblast differentiation), the IMP annotation with qualifier involved_in from PMID:24023731 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA PMID:22660580 F-box protein FBXL19-mediated ubiquitination and degradation...	ACCEPT	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IDA annotation with qualifier involved_in from PMID:22660580 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0019082 viral protein processing	TAS Reactome:R-HSA-9694631	KEEP AS NON CORE	Summary: viral protein processing is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019082 (viral protein processing), the TAS annotation with qualifier involved_in from Reactome:R-HSA-9694631 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:29142209 Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis ...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:29142209 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0031398 positive regulation of protein ubiquitination	IDA PMID:29142209 Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis ...	ACCEPT	Summary: positive regulation of protein ubiquitination is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031398 (positive regulation of protein ubiquitination), the IDA annotation with qualifier involved_in from PMID:29142209 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0097191 extrinsic apoptotic signaling pathway	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: extrinsic apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097191 (extrinsic apoptotic signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010628 positive regulation of gene expression	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:28992046 Phosphorylated E2F1 is stabilized by nuclear USP11 to drive ...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:28992046 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045724 positive regulation of cilium assembly	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of cilium assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045724 (positive regulation of cilium assembly), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1903566 positive regulation of protein localization to cilium	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of protein localization to cilium is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1903566 (positive regulation of protein localization to cilium), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0106310 protein serine kinase activity	IGI PMID:30556160 miR-219-5p inhibits tau phosphorylation by targeting TTBK1 a...	ACCEPT	Summary: protein serine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106310 (protein serine kinase activity), the IGI annotation with qualifier enables from PMID:30556160 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0010628 positive regulation of gene expression	IMP PMID:26315788 miRNA-99b-3p functions as a potential tumor suppressor by ta...	KEEP AS NON CORE	Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:26315788 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010628 positive regulation of gene expression	IMP PMID:27050373 The role of glycogen synthase kinase-3β (GSK-3β) in endometr...	KEEP AS NON CORE	Summary: positive regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010628 (positive regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:27050373 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010629 negative regulation of gene expression	IMP PMID:27050373 The role of glycogen synthase kinase-3β (GSK-3β) in endometr...	KEEP AS NON CORE	Summary: negative regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010629 (negative regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:27050373 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0090090 negative regulation of canonical Wnt signaling pathway	IGI PMID:27846906 Upregulation of miR-501-5p activates the wnt/β-catenin signa...	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IGI annotation with qualifier involved_in from PMID:27846906 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0010629 negative regulation of gene expression	IMP PMID:28122350 Transcriptional suppression of microRNA-27a contributes to l...	KEEP AS NON CORE	Summary: negative regulation of gene expression is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010629 (negative regulation of gene expression), the IMP annotation with qualifier acts_upstream_of from PMID:28122350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0045597 positive regulation of cell differentiation	IMP PMID:28122350 Transcriptional suppression of microRNA-27a contributes to l...	KEEP AS NON CORE	Summary: positive regulation of cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045597 (positive regulation of cell differentiation), the IMP annotation with qualifier involved_in from PMID:28122350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0071300 cellular response to retinoic acid	IMP PMID:28122350 Transcriptional suppression of microRNA-27a contributes to l...	KEEP AS NON CORE	Summary: cellular response to retinoic acid is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0071300 (cellular response to retinoic acid), the IMP annotation with qualifier involved_in from PMID:28122350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:2000740 negative regulation of mesenchymal stem cell differentiation	IMP PMID:24023731 miR-346 regulates osteogenic differentiation of human bone m...	KEEP AS NON CORE	Summary: negative regulation of mesenchymal stem cell differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000740 (negative regulation of mesenchymal stem cell differentiation), the IMP annotation with qualifier involved_in from PMID:24023731 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:19364825 Identification of domains responsible for ubiquitin-dependen...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:19364825 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA PMID:19364825 Identification of domains responsible for ubiquitin-dependen...	ACCEPT	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IDA annotation with qualifier involved_in from PMID:19364825 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:18846110 Identification of an antiapoptotic protein complex at death ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:18846110 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP PMID:18846110 Identification of an antiapoptotic protein complex at death ...	KEEP AS NON CORE	Summary: negative regulation of extrinsic apoptotic signaling pathway via death domain receptors is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors), the IMP annotation with qualifier involved_in from PMID:18846110 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:31073040 LMBR1L regulates lymphopoiesis through Wnt/β-catenin signali...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:31073040 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0150101 regulation of microtubule anchoring at centrosome	IMP PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol...	KEEP AS NON CORE	Summary: regulation of microtubule anchoring at centrosome is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0150101 (regulation of microtubule anchoring at centrosome), the IMP annotation with qualifier involved_in from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0010508 positive regulation of autophagy	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of autophagy is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0010508 (positive regulation of autophagy), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0042752 regulation of circadian rhythm	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: regulation of circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0042752 (regulation of circadian rhythm), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1900271 regulation of long-term synaptic potentiation	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: regulation of long-term synaptic potentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900271 (regulation of long-term synaptic potentiation), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0106027 neuron projection organization	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: neuron projection organization is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0106027 (neuron projection organization), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:28903391 Cancer/testis antigen PIWIL2 suppresses circadian rhythms by...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28903391 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0048156 tau protein binding	NAS PMID:28386764 Roles of tau protein in health and disease.	ACCEPT	Summary: tau protein binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0048156 (tau protein binding), the NAS annotation with qualifier enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0050321 tau-protein kinase activity	NAS PMID:28386764 Roles of tau protein in health and disease.	ACCEPT	Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the NAS annotation with qualifier enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0090090 negative regulation of canonical Wnt signaling pathway	IC PMID:9601641 Downregulation of beta-catenin by human Axin and its associa...	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IC annotation with qualifier involved_in from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004672 protein kinase activity	IMP PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ...	MODIFY	Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the IMP annotation with qualifier enables from PMID:16981698 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0004674 protein serine/threonine kinase activity	IMP PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IMP annotation with qualifier enables from PMID:16981698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:16981698 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0006468 protein phosphorylation	IMP PMID:16981698 GSKIP is homologous to the Axin GSK3beta interaction domain ...	ACCEPT	Summary: protein phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0006468 (protein phosphorylation), the IMP annotation with qualifier involved_in from PMID:16981698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0090090 negative regulation of canonical Wnt signaling pathway	ISS GO_REF:0000024	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:28829046 Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt sig...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:28829046 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0030010 establishment of cell polarity	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: establishment of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030010 (establishment of cell polarity), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030010 establishment of cell polarity	TAS PMID:18268107 Microtubule stabilization specifies initial neuronal polariz...	KEEP AS NON CORE	Summary: establishment of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030010 (establishment of cell polarity), the TAS annotation with qualifier involved_in from PMID:18268107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030011 maintenance of cell polarity	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: maintenance of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030011 (maintenance of cell polarity), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030011 maintenance of cell polarity	TAS PMID:18268107 Microtubule stabilization specifies initial neuronal polariz...	KEEP AS NON CORE	Summary: maintenance of cell polarity is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030011 (maintenance of cell polarity), the TAS annotation with qualifier involved_in from PMID:18268107 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030424 axon	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: axon is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030424 (axon), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030425 dendrite	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: dendrite is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030425 (dendrite), the ISS annotation with qualifier located_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030516 regulation of axon extension	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: regulation of axon extension is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030516 (regulation of axon extension), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0048814 regulation of dendrite morphogenesis	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: regulation of dendrite morphogenesis is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0048814 (regulation of dendrite morphogenesis), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0050770 regulation of axonogenesis	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: regulation of axonogenesis is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050770 (regulation of axonogenesis), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0070507 regulation of microtubule cytoskeleton organization	ISS GO_REF:0000024	ACCEPT	Summary: regulation of microtubule cytoskeleton organization is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070507 (regulation of microtubule cytoskeleton organization), the ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	NAS PMID:28386764 Roles of tau protein in health and disease.	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the NAS annotation with qualifier enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0060079 excitatory postsynaptic potential	NAS PMID:21711983 A role for Akt and glycogen synthase kinase-3 as integrators...	KEEP AS NON CORE	Summary: excitatory postsynaptic potential is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0060079 (excitatory postsynaptic potential), the NAS annotation with qualifier involved_in from PMID:21711983 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:25897075 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25897075 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP PMID:25897075 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent...	ACCEPT	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IMP annotation with qualifier involved_in from PMID:25897075 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:17139249 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0034452 dynactin binding	IPI PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol...	KEEP AS NON CORE	Summary: dynactin binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034452 (dynactin binding), the IPI annotation with qualifier enables from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1904781 positive regulation of protein localization to centrosome	IMP PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol...	KEEP AS NON CORE	Summary: positive regulation of protein localization to centrosome is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904781 (positive regulation of protein localization to centrosome), the IMP annotation with qualifier involved_in from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005813 centrosome	IDA PMID:17139249 GSK-3beta-regulated interaction of BICD with dynein is invol...	KEEP AS NON CORE	Summary: centrosome is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005813 (centrosome), the IDA annotation with qualifier located_in from PMID:17139249 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	NAS PMID:8725894 Glycogen synthase kinase 3 alpha and 3 beta do not colocaliz...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the NAS annotation with qualifier enables from PMID:8725894 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1904646 cellular response to amyloid-beta	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: cellular response to amyloid-beta is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904646 (cellular response to amyloid-beta), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:20007971 Glycogen synthase kinase 3beta interaction protein functions...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:20007971 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0031175 neuron projection development	IDA PMID:19830702 GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/bet...	ACCEPT	Summary: neuron projection development is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031175 (neuron projection development), the IDA annotation with qualifier involved_in from PMID:19830702 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:25920809 GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:25920809 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:27484798 The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kina...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:27484798 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0002020 protease binding	IPI PMID:25118933 The protease Omi regulates mitochondrial biogenesis through ...	KEEP AS NON CORE	Summary: protease binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0002020 (protease binding), the IPI annotation with qualifier enables from PMID:25118933 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004672 protein kinase activity	TAS PMID:26049140 A WNT1-regulated developmental gene cascade prevents dopamin...	MODIFY	Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the TAS annotation with qualifier enables from PMID:26049140 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0035556 intracellular signal transduction	TAS PMID:26049140 A WNT1-regulated developmental gene cascade prevents dopamin...	MARK AS OVER ANNOTATED	Summary: intracellular signal transduction is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0035556 (intracellular signal transduction), the TAS annotation with qualifier involved_in from PMID:26049140 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:1904339 negative regulation of dopaminergic neuron differentiation	TAS PMID:24431302 Wnt signaling in midbrain dopaminergic neuron development an...	KEEP AS NON CORE	Summary: negative regulation of dopaminergic neuron differentiation is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1904339 (negative regulation of dopaminergic neuron differentiation), the TAS annotation with qualifier involved_in from PMID:24431302 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004672 protein kinase activity	TAS PMID:22988876 The importance of Wnt signalling for neurodegeneration in Pa...	MODIFY	Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the TAS annotation with qualifier enables from PMID:22988876 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0004672 protein kinase activity	TAS PMID:24115276 The regulation and deregulation of Wnt signaling by PARK gen...	MODIFY	Summary: protein kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0004672 (protein kinase activity), the TAS annotation with qualifier enables from PMID:24115276 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:1990909 Wnt signalosome	TAS PMID:24115276 The regulation and deregulation of Wnt signaling by PARK gen...	ACCEPT	Summary: Wnt signalosome is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1990909 (Wnt signalosome), the TAS annotation with qualifier part_of from PMID:24115276 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030877 beta-catenin destruction complex	TAS PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua...	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the TAS annotation with qualifier part_of from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IC PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua...	ACCEPT	Summary: positive regulation of proteasomal ubiquitin-dependent protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process), the IC annotation with qualifier involved_in from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0090090 negative regulation of canonical Wnt signaling pathway	IC PMID:11955436 Control of beta-catenin phosphorylation/degradation by a dua...	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the IC annotation with qualifier involved_in from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:16315267 GSK3B polymorphisms alter transcription and splicing in Park...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:16315267 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-9762094	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9762094 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-9824995	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9824995 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-9824999	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9824999 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005654 nucleoplasm	TAS Reactome:R-HSA-9943675	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-HSA-9943675 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005654 nucleoplasm	TAS Reactome:R-NUL-9008555	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-NUL-9008555 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005654 nucleoplasm	TAS Reactome:R-NUL-9008636	ACCEPT	Summary: nucleoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from Reactome:R-NUL-9008636 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:1900181 negative regulation of protein localization to nucleus	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: negative regulation of protein localization to nucleus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1900181 (negative regulation of protein localization to nucleus), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:24391509 NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolve...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:24391509 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0016301 kinase activity	IDA PMID:24391509 NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolve...	MODIFY	Summary: kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0016301 (kinase activity), the IDA annotation with qualifier enables from PMID:24391509 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0005515 protein binding	IPI PMID:19706605 GSK-3 phosphorylates delta-catenin and negatively regulates ...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:19706605 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0046777 protein autophosphorylation	IDA PMID:23184662 Phosphorylation of eukaryotic elongation factor 2 (eEF2) by ...	ACCEPT	Summary: protein autophosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0046777 (protein autophosphorylation), the IDA annotation with qualifier involved_in from PMID:23184662 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-5339713	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5339713 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0036016 cellular response to interleukin-3	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: cellular response to interleukin-3 is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0036016 (cellular response to interleukin-3), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: extrinsic apoptotic signaling pathway in absence of ligand is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005829 cytosol	TAS Reactome:R-HSA-2399966	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2399966 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-1504186	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-1504186 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195251	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195251 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195275	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195275 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195280	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195280 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195283	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195283 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195287	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195287 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195300	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195300 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195304	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195304 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-195318	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-195318 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-201677	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-201677 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-201685	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-201685 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-2130279	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2130279 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-2130282	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2130282 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-2130286	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-2130286 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-3371435	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-3371435 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-399951	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-399951 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4791278	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4791278 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4827388	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4827388 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4839634	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839634 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4839635	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839635 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4839638	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839638 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4839734	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839734 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-4839746	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-4839746 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-5229343	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5229343 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-5323526	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5323526 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-5368596	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5368596 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-5610732	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-5610732 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-9683664	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9683664 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-9687724	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9687724 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-HSA-9729260	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-HSA-9729260 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-NUL-1458902	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-1458902 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005829 cytosol	TAS Reactome:R-NUL-209146	ACCEPT	Summary: cytosol is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from Reactome:R-NUL-209146 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0007623 circadian rhythm	ISS GO_REF:0000024	KEEP AS NON CORE	Summary: circadian rhythm is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0007623 (circadian rhythm), the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0032092 positive regulation of protein binding	ISS GO_REF:0000024	MARK AS OVER ANNOTATED	Summary: positive regulation of protein binding is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032092 (positive regulation of protein binding), the ISS annotation with qualifier involved_in from GO_REF:0000024 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:9072970 Nuclear export of NF-ATc enhanced by glycogen synthase kinas...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:9072970 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030877 beta-catenin destruction complex	TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake.	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the TAS annotation with qualifier part_of from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045719 negative regulation of glycogen biosynthetic process	TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake.	ACCEPT	Summary: negative regulation of glycogen biosynthetic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045719 (negative regulation of glycogen biosynthetic process), the TAS annotation with qualifier involved_in from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0050321 tau-protein kinase activity	IDA PMID:14690523 Primed phosphorylation of tau at Thr231 by glycogen synthase...	ACCEPT	Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IDA annotation with qualifier enables from PMID:14690523 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade	IMP PMID:9072970 Nuclear export of NF-ATc enhanced by glycogen synthase kinas...	KEEP AS NON CORE	Summary: negative regulation of calcineurin-NFAT signaling cascade is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0070885 (negative regulation of calcineurin-NFAT signaling cascade), the IMP annotation with qualifier involved_in from PMID:9072970 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0090090 negative regulation of canonical Wnt signaling pathway	TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake.	ACCEPT	Summary: negative regulation of canonical Wnt signaling pathway is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the TAS annotation with qualifier involved_in from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:2000077 negative regulation of type B pancreatic cell development	TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake.	KEEP AS NON CORE	Summary: negative regulation of type B pancreatic cell development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000077 (negative regulation of type B pancreatic cell development), the TAS annotation with qualifier involved_in from PMID:19366350 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:2000466 negative regulation of glycogen (starch) synthase activity	TAS PMID:19366350 Glycogen synthase kinase 3: more than a namesake.	ACCEPT	Summary: negative regulation of glycogen (starch) synthase activity is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:2000466 (negative regulation of glycogen (starch) synthase activity), the TAS annotation with qualifier involved_in from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:18348280 Importance of autophosphorylation at Ser186 in the A-loop of...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:18348280 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0019901 protein kinase binding	IPI PMID:18348280 Importance of autophosphorylation at Ser186 in the A-loop of...	KEEP AS NON CORE	Summary: protein kinase binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables from PMID:18348280 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005813 centrosome	IDA PMID:21399614 Novel asymmetrically localizing components of human centroso...	KEEP AS NON CORE	Summary: centrosome is retained as a non-core cellular-component/localization annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005813 (centrosome), the IDA annotation with qualifier located_in from PMID:21399614 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005737 cytoplasm	IDA PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005886 plasma membrane	IDA PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC...	ACCEPT	Summary: plasma membrane is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006468 protein phosphorylation	IDA PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC...	ACCEPT	Summary: protein phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0006468 (protein phosphorylation), the IDA annotation with qualifier involved_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0032886 regulation of microtubule-based process	IMP PMID:20937854 ErbB2 receptor controls microtubule capture by recruiting AC...	ACCEPT	Summary: regulation of microtubule-based process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0032886 (regulation of microtubule-based process), the IMP annotation with qualifier involved_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:9731200 Human dynamin-like protein interacts with the glycogen synth...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9731200 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding	IPI PMID:20864106 PTEN differentially regulates expressions of ICAM-1 and VCAM...	KEEP AS NON CORE	Summary: RNA polymerase II-specific DNA-binding transcription factor binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor binding), the IPI annotation with qualifier enables from PMID:20864106 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0031625 ubiquitin protein ligase binding	IPI PMID:21118991 The EDD E3 ubiquitin ligase ubiquitinates and up-regulates b...	KEEP AS NON CORE	Summary: ubiquitin protein ligase binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031625 (ubiquitin protein ligase binding), the IPI annotation with qualifier enables from PMID:21118991 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0002039 p53 binding	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	KEEP AS NON CORE	Summary: p53 binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0002039 (p53 binding), the IDA annotation with qualifier enables from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005634 nucleus	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	ACCEPT	Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0006983 ER overload response	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	KEEP AS NON CORE	Summary: ER overload response is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0006983 (ER overload response), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0018105 peptidyl-serine phosphorylation	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	ACCEPT	Summary: peptidyl-serine phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0018105 (peptidyl-serine phosphorylation), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0043066 negative regulation of apoptotic process	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	KEEP AS NON CORE	Summary: negative regulation of apoptotic process is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0043066 (negative regulation of apoptotic process), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0046827 positive regulation of protein export from nucleus	IDA PMID:14744935 Endoplasmic reticulum stress induces p53 cytoplasmic localiz...	KEEP AS NON CORE	Summary: positive regulation of protein export from nucleus is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0046827 (positive regulation of protein export from nucleus), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0001837 epithelial to mesenchymal transition	IMP PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	KEEP AS NON CORE	Summary: epithelial to mesenchymal transition is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0001837 (epithelial to mesenchymal transition), the IMP annotation with qualifier involved_in from PMID:15448698 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005515 protein binding	IPI PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:15448698 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005634 nucleus	IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	ACCEPT	Summary: nucleus is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0016301 kinase activity	IDA PMID:15448698 Dual regulation of Snail by GSK-3beta-mediated phosphorylati...	MODIFY	Summary: kinase activity is directionally related to GSK3B biology but is not the best curation target; protein serine/threonine kinase activity better captures the specific supported function or process. Reason: For GO:0016301 (kinase activity), the IDA annotation with qualifier enables from PMID:15448698 supports a relationship to GSK3B, but the current term is less precise than protein serine/threonine kinase activity for the evidence and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves the biological intent while pointing curators to the more informative GO term. Proposed replacements: protein serine/threonine kinase activity
GO:0050321 tau-protein kinase activity	IDA PMID:16365045 The low density lipoprotein receptor-related protein 6 inter...	ACCEPT	Summary: tau-protein kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0050321 (tau-protein kinase activity), the IDA annotation with qualifier enables from PMID:16365045 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0031333 negative regulation of protein-containing complex assembly	IMP PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d...	KEEP AS NON CORE	Summary: negative regulation of protein-containing complex assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031333 (negative regulation of protein-containing complex assembly), the IMP annotation with qualifier involved_in from PMID:16188939 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0005737 cytoplasm	IDA PMID:19038973 Identification of WNT/beta-CATENIN signaling pathway compone...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:19038973 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0021766 hippocampus development	IMP PMID:19581563 Association of GSK3beta polymorphisms with brain structural ...	KEEP AS NON CORE	Summary: hippocampus development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0021766 (hippocampus development), the IMP annotation with qualifier involved_in from PMID:19581563 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0071109 superior temporal gyrus development	IMP PMID:19581563 Association of GSK3beta polymorphisms with brain structural ...	KEEP AS NON CORE	Summary: superior temporal gyrus development is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0071109 (superior temporal gyrus development), the IMP annotation with qualifier involved_in from PMID:19581563 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0001954 positive regulation of cell-matrix adhesion	IMP PMID:18156211 Regulation of endothelial cell cytoskeletal reorganization b...	KEEP AS NON CORE	Summary: positive regulation of cell-matrix adhesion is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0001954 (positive regulation of cell-matrix adhesion), the IMP annotation with qualifier involved_in from PMID:18156211 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0030877 beta-catenin destruction complex	IDA PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d...	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:16188939 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0045732 positive regulation of protein catabolic process	IC PMID:16188939 The adenomatous polyposis coli protein (APC) exists in two d...	ACCEPT	Summary: positive regulation of protein catabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0045732 (positive regulation of protein catabolic process), the IC annotation with qualifier involved_in from PMID:16188939 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005737 cytoplasm	IDA PMID:18787224 Constitutive activation of the Wnt canonical pathway in mant...	ACCEPT	Summary: cytoplasm is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from PMID:18787224 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:11035810 Phosphorylation and inactivation of glycogen synthase kinase...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:11035810 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0034236 protein kinase A catalytic subunit binding	IPI PMID:11035810 Phosphorylation and inactivation of glycogen synthase kinase...	KEEP AS NON CORE	Summary: protein kinase A catalytic subunit binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0034236 (protein kinase A catalytic subunit binding), the IPI annotation with qualifier enables from PMID:11035810 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005977 glycogen metabolic process	IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu...	ACCEPT	Summary: glycogen metabolic process is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005977 (glycogen metabolic process), the IDA annotation with qualifier involved_in from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0008013 beta-catenin binding	IPI PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu...	ACCEPT	Summary: beta-catenin binding is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0008013 (beta-catenin binding), the IPI annotation with qualifier enables from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0030877 beta-catenin destruction complex	IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu...	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0031334 positive regulation of protein-containing complex assembly	IDA PMID:8638126 Binding of GSK3beta to the APC-beta-catenin complex and regu...	KEEP AS NON CORE	Summary: positive regulation of protein-containing complex assembly is retained as a non-core biological-process annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0031334 (positive regulation of protein-containing complex assembly), the IDA annotation with qualifier involved_in from PMID:8638126 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.
GO:0004674 protein serine/threonine kinase activity	ISS GO_REF:0000024	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the ISS annotation with qualifier enables from GO_REF:0000024 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:9482734 Axin, a negative regulator of the Wnt signaling pathway, for...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9482734 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0004674 protein serine/threonine kinase activity	IDA PMID:11104755 Substitution of a glycogen synthase kinase-3beta phosphoryla...	ACCEPT	Summary: protein serine/threonine kinase activity is retained as a core molecular-function annotation for GSK3B; it captures activity or binding specificity within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation with qualifier enables from PMID:11104755 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0018105 peptidyl-serine phosphorylation	IDA PMID:11104755 Substitution of a glycogen synthase kinase-3beta phosphoryla...	ACCEPT	Summary: peptidyl-serine phosphorylation is retained as a core biological-process annotation for GSK3B; it captures process participation within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0018105 (peptidyl-serine phosphorylation), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:11104755 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0035556 intracellular signal transduction	IDA PMID:14749367 Regulation of apoptosis by the Ft1 protein, a new modulator ...	MARK AS OVER ANNOTATED	Summary: intracellular signal transduction is marked over-annotated for GSK3B because this biological-process term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0035556 (intracellular signal transduction), the IDA annotation with qualifier acts_upstream_of_or_within from PMID:14749367 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0005515 protein binding	IPI PMID:9601641 Downregulation of beta-catenin by human Axin and its associa...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:9601641 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0030877 beta-catenin destruction complex	IDA PMID:9601641 Downregulation of beta-catenin by human Axin and its associa...	ACCEPT	Summary: beta-catenin destruction complex is retained as a core cellular-component/localization annotation for GSK3B; it captures site of action or component context within the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier part_of from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. This action keeps the term because it provides a specific, evidence-backed kinase/substrate, pathway, or localization annotation rather than only a downstream phenotype or generic interaction label.
GO:0005515 protein binding	IPI PMID:12927815 Molecular characterization of human ninein protein: two dist...	MARK AS OVER ANNOTATED	Summary: protein binding is marked over-annotated for GSK3B because this molecular-function term is too generic, interaction-map-like, or weakly informative relative to the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0005515 (protein binding), the IPI annotation with qualifier enables from PMID:12927815 may reflect a real assay result or interaction, but this GO term does not identify the specific kinase/substrate, pathway, or localization annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific annotations are present, so this is marked over-annotated rather than accepted as a core function.
GO:0051059 NF-kappaB binding	IPI PMID:15465828 Phosphorylation of serine 468 by GSK-3beta negatively regula...	KEEP AS NON CORE	Summary: NF-kappaB binding is retained as a non-core molecular-function annotation for GSK3B; it records a supported context, interaction, localization, or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites where these reactions occur. Reason: For GO:0051059 (NF-kappaB binding), the IPI annotation with qualifier enables from PMID:15465828 supports retaining the annotation, but the term describes a context-specific outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core prevents broad pathway participation from being promoted to core function.

📄 View Raw YAML

id: P49841
gene_symbol: GSK3B
product_type: PROTEIN
status: COMPLETE
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'GSK3B encodes glycogen synthase kinase-3 beta, a constitutively active,
  ATP-dependent serine/threonine protein kinase regulated by inhibitory Ser-9 and
  activating Tyr-216 phosphorylation. GSK3B phosphorylates primed and unprimed protein
  substrates across glucose/glycogen metabolism, canonical Wnt/beta-catenin signaling,
  transcription-factor regulation, protein ubiquitination/degradation, autophagy,
  apoptosis, neuronal polarity, microtubule regulation, and tau biology. Core disease-relevant
  functions include tau-protein kinase activity that reduces tau microtubule binding,
  negative regulation of canonical Wnt signaling through the beta-catenin destruction
  complex, and insulin-linked negative control of glycogen synthesis.'
alternative_products:
- name: 1 (GSK-3beta1)
  id: P49841-1
- name: 2 (GSK-3beta2, neuron-specific)
  id: P49841-2
  sequence_note: VSP_004790
existing_annotations:
- term:
    id: GO:0030424
    label: axon
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      axon is retained as a non-core cellular-component/localization annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030424 (axon), the IBA annotation with qualifier is_active_in from GO_REF:0000033
      supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      dendrite is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030425 (dendrite), the IBA annotation with qualifier is_active_in from
      GO_REF:0000033 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      nucleus is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005634 (nucleus), the IBA annotation with qualifier is_active_in from
      GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IBA annotation with qualifier is_active_in from
      GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the IBA annotation with qualifier is_active_in from
      GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0030154
    label: cell differentiation
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      cell differentiation is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030154 (cell differentiation), the IBA annotation with qualifier involved_in
      from GO_REF:0000033 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0050321
    label: tau-protein kinase activity
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: >-
      tau-protein kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0050321 (tau-protein kinase activity), the IBA annotation with qualifier
      enables from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      IBA annotation with qualifier involved_in from GO_REF:0000033 is consistent
      with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of
      primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau,
      and protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032007
    label: negative regulation of TOR signaling
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of TOR signaling is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0032007 (negative regulation of TOR signaling), the IBA annotation with
      qualifier involved_in from GO_REF:0000033 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010508
    label: positive regulation of autophagy
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of autophagy is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010508 (positive regulation of autophagy), the IBA annotation with qualifier
      involved_in from GO_REF:0000033 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0043525
    label: positive regulation of neuron apoptotic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of neuron apoptotic process is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0043525 (positive regulation of neuron apoptotic process), the IBA annotation
      with qualifier involved_in from GO_REF:0000033 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of proteasomal ubiquitin-dependent protein catabolic process
      is retained as a core biological-process annotation for GSK3B; it captures process
      participation within the synthesized core biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein
      catabolic process), the IBA annotation with qualifier involved_in from GO_REF:0000033
      is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0070507
    label: regulation of microtubule cytoskeleton organization
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      regulation of microtubule cytoskeleton organization is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0070507 (regulation of microtubule cytoskeleton organization), the IBA
      annotation with qualifier involved_in from GO_REF:0000033 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0010975
    label: regulation of neuron projection development
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      regulation of neuron projection development is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0010975 (regulation of neuron projection development), the IBA annotation
      with qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: is_active_in
  review:
    summary: >-
      glutamatergic synapse is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0098978 (glutamatergic synapse), the IBA annotation with qualifier is_active_in
      from GO_REF:0000033 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0008286
    label: insulin receptor signaling pathway
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: involved_in
  review:
    summary: >-
      insulin receptor signaling pathway is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0008286 (insulin receptor signaling pathway), the IBA annotation with
      qualifier involved_in from GO_REF:0000033 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0008013
    label: beta-catenin binding
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: enables
  review:
    summary: >-
      beta-catenin binding is retained as a core molecular-function annotation for
      GSK3B; it captures activity or binding specificity within the synthesized core
      biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0008013 (beta-catenin binding), the IBA annotation with qualifier enables
      from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: IBA
  original_reference_id: GO_REF:0000033
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the IBA annotation with qualifier
      part_of from GO_REF:0000033 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: enables
  review:
    summary: >-
      protein kinase activity is directionally related to GSK3B biology but is not
      the best curation target; protein serine/threonine kinase activity better captures
      the specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0004672 (protein kinase activity), the IEA annotation with qualifier
      enables from GO_REF:0000120 supports a relationship to GSK3B, but the current
      term is less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IEA annotation
      with qualifier enables from GO_REF:0000120 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005524
    label: ATP binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000002
  qualifier: enables
  review:
    summary: >-
      ATP binding is retained as a core molecular-function annotation for GSK3B; it
      captures activity or binding specificity within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005524 (ATP binding), the IEA annotation with qualifier enables from
      GO_REF:0000002 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005634 (nucleus), the IEA annotation with qualifier located_in from
      GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IEA annotation with qualifier located_in from
      GO_REF:0000044 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IEA
  original_reference_id: GO_REF:0000044
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the IEA annotation with qualifier located_in
      from GO_REF:0000044 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0009968
    label: negative regulation of signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of signal transduction is marked over-annotated for GSK3B
      because this biological-process term is too generic, interaction-map-like, or
      weakly informative relative to the gene-specific biology: GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0009968 (negative regulation of signal transduction), the IEA annotation
      with qualifier involved_in from GO_REF:0000117 may reflect a real assay result
      or interaction, but this GO term does not identify the specific kinase/substrate,
      pathway, or localization annotation that explains GSK3B's role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific
      annotations are present, so this is marked over-annotated rather than accepted
      as a core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0019082
    label: viral protein processing
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      viral protein processing is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0019082 (viral protein processing), the IEA annotation with qualifier
      involved_in from GO_REF:0000117 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0031398
    label: positive regulation of protein ubiquitination
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein ubiquitination is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0031398 (positive regulation of protein ubiquitination), the IEA annotation
      with qualifier involved_in from GO_REF:0000117 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of proteasomal ubiquitin-dependent protein catabolic process
      is retained as a core biological-process annotation for GSK3B; it captures process
      participation within the synthesized core biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein
      catabolic process), the IEA annotation with qualifier involved_in from GO_REF:0000117
      is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0034236
    label: protein kinase A catalytic subunit binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: enables
  review:
    summary: >-
      protein kinase A catalytic subunit binding is retained as a non-core molecular-function
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0034236 (protein kinase A catalytic subunit binding), the IEA annotation
      with qualifier enables from GO_REF:0000117 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0050321
    label: tau-protein kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: enables
  review:
    summary: >-
      tau-protein kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0050321 (tau-protein kinase activity), the IEA annotation with qualifier
      enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0098793
    label: presynapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000108
  qualifier: located_in
  review:
    summary: >-
      presynapse is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0098793 (presynapse), the IEA annotation with qualifier located_in from
      GO_REF:0000108 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:2000077
    label: negative regulation of type B pancreatic cell development
  evidence_type: IEA
  original_reference_id: GO_REF:0000117
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of type B pancreatic cell development is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:2000077 (negative regulation of type B pancreatic cell development),
      the IEA annotation with qualifier involved_in from GO_REF:0000117 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:10481074
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:10481074 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11004522
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:11004522 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11035810
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:11035810 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:11738041
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:11738041 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12421363
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:12421363 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12434148
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:12434148 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:14744935
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:14744935 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15147888
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:15147888 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15752768
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:15752768 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16282323
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:16282323 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16365045
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:16365045 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16890161
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:16890161 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17078951
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17078951 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17139249
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17139249 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17317006
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17317006 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17318191
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17318191 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17510365
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17510365 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:17601533
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:17601533 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18045539
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:18045539 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18505846
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:18505846 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18687691
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:18687691 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19131971
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19131971 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19202075
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19202075 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19249679
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19249679 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19303846
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19303846 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19411070
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19411070 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19759537
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19759537 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20080667
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20080667 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20368287
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20368287 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20389281
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20389281 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20856200
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20856200 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21118991
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21118991 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21217772
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21217772 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21242974
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21242974 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21743491
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21743491 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21900206
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21900206 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21985244
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21985244 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:21988832
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:21988832 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22470507
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:22470507 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22682247
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:22682247 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22699938
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:22699938 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:22773187
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:22773187 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23010592
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:23010592 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23455922
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:23455922 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:23602568
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:23602568 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24165324
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:24165324 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24879152
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:24879152 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24976009
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:24976009 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25241761
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:25241761 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26496610
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:26496610 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:26618561
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:26618561 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27601169
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:27601169 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:29568061
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:29568061 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31640277
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:31640277 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:32707033
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:32707033 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33248025
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:33248025 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:33961781
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:33961781 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:34232536
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:34232536 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35063084
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:35063084 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35271311
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:35271311 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:35512704
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:35512704 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:8638126
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:8638126 may reflect a real assay result or interaction, but this GO
      term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the IEA annotation with qualifier located_in from
      GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0007127
    label: meiosis I
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      meiosis I is retained as a non-core biological-process annotation for GSK3B;
      it records a supported context, interaction, localization, or pathway branch
      that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0007127 (meiosis I), the IEA annotation with qualifier involved_in from
      GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0007623
    label: circadian rhythm
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      circadian rhythm is retained as a non-core biological-process annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0007623 (circadian rhythm), the IEA annotation with qualifier involved_in
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0008013
    label: beta-catenin binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: enables
  review:
    summary: >-
      beta-catenin binding is retained as a core molecular-function annotation for
      GSK3B; it captures activity or binding specificity within the synthesized core
      biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0008013 (beta-catenin binding), the IEA annotation with qualifier enables
      from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0008286
    label: insulin receptor signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      insulin receptor signaling pathway is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0008286 (insulin receptor signaling pathway), the IEA annotation with
      qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0010508
    label: positive regulation of autophagy
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of autophagy is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010508 (positive regulation of autophagy), the IEA annotation with qualifier
      involved_in from GO_REF:0000107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of gene expression is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010628 (positive regulation of gene expression), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010954
    label: positive regulation of protein processing
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein processing is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010954 (positive regulation of protein processing), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0014069
    label: postsynaptic density
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      postsynaptic density is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0014069 (postsynaptic density), the IEA annotation with qualifier located_in
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: enables
  review:
    summary: >-
      protein kinase binding is retained as a non-core molecular-function annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0019901 (protein kinase binding), the IEA annotation with qualifier enables
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030426
    label: growth cone
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      growth cone is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030426 (growth cone), the IEA annotation with qualifier located_in from
      GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the IEA annotation with qualifier
      part_of from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0031663
    label: lipopolysaccharide-mediated signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      lipopolysaccharide-mediated signaling pathway is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0031663 (lipopolysaccharide-mediated signaling pathway), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032007
    label: negative regulation of TOR signaling
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of TOR signaling is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0032007 (negative regulation of TOR signaling), the IEA annotation with
      qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032481
    label: positive regulation of type I interferon production
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of type I interferon production is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0032481 (positive regulation of type I interferon production), the IEA
      annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032886
    label: regulation of microtubule-based process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      regulation of microtubule-based process is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0032886 (regulation of microtubule-based process), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0036016
    label: cellular response to interleukin-3
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      cellular response to interleukin-3 is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0036016 (cellular response to interleukin-3), the IEA annotation with
      qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0042752
    label: regulation of circadian rhythm
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      regulation of circadian rhythm is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0042752 (regulation of circadian rhythm), the IEA annotation with qualifier
      involved_in from GO_REF:0000107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0042981
    label: regulation of apoptotic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      regulation of apoptotic process is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0042981 (regulation of apoptotic process), the IEA annotation with qualifier
      involved_in from GO_REF:0000107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0043025
    label: neuronal cell body
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      neuronal cell body is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0043025 (neuronal cell body), the IEA annotation with qualifier located_in
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0043198
    label: dendritic shaft
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      dendritic shaft is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0043198 (dendritic shaft), the IEA annotation with qualifier located_in
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0043491
    label: phosphatidylinositol 3-kinase/protein kinase B signal transduction
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      phosphatidylinositol 3-kinase/protein kinase B signal transduction is retained
      as a non-core biological-process annotation for GSK3B; it records a supported
      context, interaction, localization, or pathway branch that is secondary to GSK3B
      catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0043491 (phosphatidylinositol 3-kinase/protein kinase B signal transduction),
      the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0044297
    label: cell body
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      cell body is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0044297 (cell body), the IEA annotation with qualifier located_in from
      GO_REF:0000107 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0045719
    label: negative regulation of glycogen biosynthetic process
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of glycogen biosynthetic process is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0045719 (negative regulation of glycogen biosynthetic process), the IEA
      annotation with qualifier involved_in from GO_REF:0000120 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0045724
    label: positive regulation of cilium assembly
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of cilium assembly is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0045724 (positive regulation of cilium assembly), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0045879
    label: negative regulation of smoothened signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of smoothened signaling pathway is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0045879 (negative regulation of smoothened signaling pathway), the IEA
      annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0048471
    label: perinuclear region of cytoplasm
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: located_in
  review:
    summary: >-
      perinuclear region of cytoplasm is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0048471 (perinuclear region of cytoplasm), the IEA annotation with qualifier
      located_in from GO_REF:0000107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0070059
    label: intrinsic apoptotic signaling pathway in response to endoplasmic 
      reticulum stress
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
      is retained as a non-core biological-process annotation for GSK3B; it records
      a supported context, interaction, localization, or pathway branch that is secondary
      to GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic
      reticulum stress), the IEA annotation with qualifier involved_in from GO_REF:0000107
      supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0070840
    label: dynein complex binding
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: enables
  review:
    summary: >-
      dynein complex binding is retained as a non-core molecular-function annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0070840 (dynein complex binding), the IEA annotation with qualifier enables
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0071385
    label: cellular response to glucocorticoid stimulus
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      cellular response to glucocorticoid stimulus is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0071385 (cellular response to glucocorticoid stimulus), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0072687
    label: meiotic spindle
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: is_active_in
  review:
    summary: >-
      meiotic spindle is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0072687 (meiotic spindle), the IEA annotation with qualifier is_active_in
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      IEA annotation with qualifier involved_in from GO_REF:0000107 is consistent
      with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of
      primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau,
      and protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0097191
    label: extrinsic apoptotic signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      extrinsic apoptotic signaling pathway is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0097191 (extrinsic apoptotic signaling pathway), the IEA annotation with
      qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0097192
    label: extrinsic apoptotic signaling pathway in absence of ligand
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      extrinsic apoptotic signaling pathway in absence of ligand is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand),
      the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: is_active_in
  review:
    summary: >-
      glutamatergic synapse is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0098978 (glutamatergic synapse), the IEA annotation with qualifier is_active_in
      from GO_REF:0000107 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: IEA
  original_reference_id: GO_REF:0000120
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the IEA annotation with qualifier
      enables from GO_REF:0000120 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:1900026
    label: positive regulation of substrate adhesion-dependent cell spreading
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of substrate adhesion-dependent cell spreading is retained
      as a non-core biological-process annotation for GSK3B; it records a supported
      context, interaction, localization, or pathway branch that is secondary to GSK3B
      catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1900026 (positive regulation of substrate adhesion-dependent cell spreading),
      the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1900271
    label: regulation of long-term synaptic potentiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      regulation of long-term synaptic potentiation is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1900271 (regulation of long-term synaptic potentiation), the IEA annotation
      with qualifier involved_in from GO_REF:0000107 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1901030
    label: positive regulation of mitochondrial outer membrane permeabilization 
      involved in apoptotic signaling pathway
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of mitochondrial outer membrane permeabilization involved
      in apoptotic signaling pathway is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization
      involved in apoptotic signaling pathway), the IEA annotation with qualifier
      involved_in from GO_REF:0000107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1903566
    label: positive regulation of protein localization to cilium
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein localization to cilium is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1903566 (positive regulation of protein localization to cilium), the
      IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1904780
    label: negative regulation of protein localization to centrosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of protein localization to centrosome is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1904780 (negative regulation of protein localization to centrosome),
      the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1990904
    label: ribonucleoprotein complex
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: part_of
  review:
    summary: >-
      ribonucleoprotein complex is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1990904 (ribonucleoprotein complex), the IEA annotation with qualifier
      part_of from GO_REF:0000107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1990909
    label: Wnt signalosome
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: part_of
  review:
    summary: >-
      Wnt signalosome is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:1990909 (Wnt signalosome), the IEA annotation with qualifier part_of
      from GO_REF:0000107 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:2000727
    label: positive regulation of cardiac muscle cell differentiation
  evidence_type: IEA
  original_reference_id: GO_REF:0000107
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of cardiac muscle cell differentiation is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:2000727 (positive regulation of cardiac muscle cell differentiation),
      the IEA annotation with qualifier involved_in from GO_REF:0000107 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:40274799
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:40274799 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0060070
    label: canonical Wnt signaling pathway
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4641262
  qualifier: involved_in
  review:
    summary: >-
      canonical Wnt signaling pathway is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0060070 (canonical Wnt signaling pathway), the TAS annotation with qualifier
      involved_in from Reactome:R-HSA-4641262 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:1900034
    label: regulation of cellular response to heat
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3371453
  qualifier: involved_in
  review:
    summary: >-
      regulation of cellular response to heat is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1900034 (regulation of cellular response to heat), the TAS annotation
      with qualifier involved_in from Reactome:R-HSA-3371453 supports retaining the
      annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195283
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-195283 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195287
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-195287 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195300
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-195300 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-201677
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-201677 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3371435
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-3371435 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-399951
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-399951 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610732
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-5610732 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9683664
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9683664 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9729260
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9729260 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9762094
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9762094 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9824995
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9824995 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9824999
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9824999 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929360
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9929360 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9943675
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-HSA-9943675 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-209146
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-NUL-209146 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9008636
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the TAS annotation
      with qualifier enables from Reactome:R-NUL-9008636 is consistent with GSK3B's
      core role in ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. This action keeps the term because it provides a specific, evidence-backed
      kinase/substrate, pathway, or localization annotation rather than only a downstream
      phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:12223487
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from
      PMID:12223487 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:12223487
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
      PMID:12223487 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: NAS
  original_reference_id: PMID:9601641
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the NAS annotation with qualifier
      part_of from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  evidence_type: NAS
  original_reference_id: PMID:9601641
  qualifier: involved_in
  review:
    summary: >-
      proteasome-mediated ubiquitin-dependent protein catabolic process is retained
      as a core biological-process annotation for GSK3B; it captures process participation
      within the synthesized core biology: GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process),
      the NAS annotation with qualifier involved_in from PMID:9601641 is consistent
      with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of
      primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau,
      and protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0046825
    label: regulation of protein export from nucleus
  evidence_type: IDA
  original_reference_id: PMID:12223487
  qualifier: involved_in
  review:
    summary: >-
      regulation of protein export from nucleus is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0046825 (regulation of protein export from nucleus), the IDA annotation
      with qualifier involved_in from PMID:12223487 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0060070
    label: canonical Wnt signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:10428961
  qualifier: involved_in
  review:
    summary: >-
      canonical Wnt signaling pathway is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0060070 (canonical Wnt signaling pathway), the IDA annotation with qualifier
      involved_in from PMID:10428961 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IMP
  original_reference_id: PMID:25733715
  qualifier: enables
  review:
    summary: >-
      protein kinase activity is directionally related to GSK3B biology but is not
      the best curation target; protein serine/threonine kinase activity better captures
      the specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0004672 (protein kinase activity), the IMP annotation with qualifier
      enables from PMID:25733715 supports a relationship to GSK3B, but the current
      term is less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032880
    label: regulation of protein localization
  evidence_type: IMP
  original_reference_id: PMID:25733715
  qualifier: involved_in
  review:
    summary: >-
      regulation of protein localization is marked over-annotated for GSK3B because
      this biological-process term is too generic, interaction-map-like, or weakly
      informative relative to the gene-specific biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0032880 (regulation of protein localization), the IMP annotation with
      qualifier involved_in from PMID:25733715 may reflect a real assay result or
      interaction, but this GO term does not identify the specific kinase/substrate,
      pathway, or localization annotation that explains GSK3B's role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific
      annotations are present, so this is marked over-annotated rather than accepted
      as a core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:16705181
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:16705181 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0045879
    label: negative regulation of smoothened signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:16705181
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of smoothened signaling pathway is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0045879 (negative regulation of smoothened signaling pathway), the IDA
      annotation with qualifier involved_in from PMID:16705181 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: IDA
  original_reference_id: GO_REF:0000052
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the IDA annotation with qualifier located_in from
      GO_REF:0000052 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: EXP
  original_reference_id: PMID:21029237
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005634 (nucleus), the EXP annotation with qualifier located_in from
      PMID:21029237 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:21029237
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from
      PMID:21029237 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:25169422
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from
      PMID:25169422 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:25733715
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from
      PMID:25733715 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: EXP
  original_reference_id: PMID:35606353
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the EXP annotation with qualifier located_in from
      PMID:35606353 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:17050006
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:17050006 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:17681942
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:17681942 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:21343617
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:21343617 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:22539723
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:22539723 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:25827072
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:25827072 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:28992046
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:28992046 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: EXP
  original_reference_id: PMID:29059170
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the EXP annotation with qualifier
      enables from PMID:29059170 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032481
    label: positive regulation of type I interferon production
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of type I interferon production is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0032481 (positive regulation of type I interferon production), the ISS
      annotation with qualifier involved_in from GO_REF:0000024 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0160213
    label: beta-arrestin-dependent dopamine receptor signaling pathway
  evidence_type: NAS
  original_reference_id: PMID:21711983
  qualifier: involved_in
  review:
    summary: >-
      beta-arrestin-dependent dopamine receptor signaling pathway is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0160213 (beta-arrestin-dependent dopamine receptor signaling pathway),
      the NAS annotation with qualifier involved_in from PMID:21711983 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0019082
    label: viral protein processing
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9683610
  qualifier: involved_in
  review:
    summary: >-
      viral protein processing is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0019082 (viral protein processing), the TAS annotation with qualifier
      involved_in from Reactome:R-HSA-9683610 supports retaining the annotation, but
      the term describes a context-specific outcome or peripheral branch rather than
      the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0003170
    label: heart valve development
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      heart valve development is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0003170 (heart valve development), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:25897075
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:25897075 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0016055
    label: Wnt signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:18156211
  qualifier: involved_in
  review:
    summary: >-
      Wnt signaling pathway is retained as a core biological-process annotation for
      GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0016055 (Wnt signaling pathway), the IMP annotation with qualifier involved_in
      from PMID:18156211 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: IMP
  original_reference_id: PMID:24023731
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      IMP annotation with qualifier involved_in from PMID:24023731 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005788
    label: endoplasmic reticulum lumen
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9929360
  qualifier: located_in
  review:
    summary: >-
      endoplasmic reticulum lumen is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005788 (endoplasmic reticulum lumen), the TAS annotation with qualifier
      located_in from Reactome:R-HSA-9929360 supports retaining the annotation, but
      the term describes a context-specific outcome or peripheral branch rather than
      the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: IDA
  original_reference_id: PMID:18593713
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier
      part_of from PMID:18593713 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0097110
    label: scaffold protein binding
  evidence_type: IPI
  original_reference_id: PMID:18593713
  qualifier: enables
  review:
    summary: >-
      scaffold protein binding is retained as a non-core molecular-function annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0097110 (scaffold protein binding), the IPI annotation with qualifier
      enables from PMID:18593713 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0034976
    label: response to endoplasmic reticulum stress
  evidence_type: IDA
  original_reference_id: PMID:21343617
  qualifier: involved_in
  review:
    summary: >-
      response to endoplasmic reticulum stress is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0034976 (response to endoplasmic reticulum stress), the IDA annotation
      with qualifier involved_in from PMID:21343617 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:21343617
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:21343617 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:1903940
    label: negative regulation of TORC2 signaling
  evidence_type: IDA
  original_reference_id: PMID:21343617
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of TORC2 signaling is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1903940 (negative regulation of TORC2 signaling), the IDA annotation
      with qualifier involved_in from PMID:21343617 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15448698
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:15448698 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:25827072
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:25827072 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:29059170
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:29059170 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0010719
    label: negative regulation of epithelial to mesenchymal transition
  evidence_type: IDA
  original_reference_id: PMID:15448698
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of epithelial to mesenchymal transition is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010719 (negative regulation of epithelial to mesenchymal transition),
      the IDA annotation with qualifier involved_in from PMID:15448698 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010719
    label: negative regulation of epithelial to mesenchymal transition
  evidence_type: IDA
  original_reference_id: PMID:25827072
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of epithelial to mesenchymal transition is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010719 (negative regulation of epithelial to mesenchymal transition),
      the IDA annotation with qualifier involved_in from PMID:25827072 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010719
    label: negative regulation of epithelial to mesenchymal transition
  evidence_type: IDA
  original_reference_id: PMID:29059170
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of epithelial to mesenchymal transition is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010719 (negative regulation of epithelial to mesenchymal transition),
      the IDA annotation with qualifier involved_in from PMID:29059170 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:34058472
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:34058472 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: EXP
  original_reference_id: PMID:17989287
  qualifier: is_active_in
  review:
    summary: >-
      glutamatergic synapse is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0098978 (glutamatergic synapse), the EXP annotation with qualifier is_active_in
      from PMID:17989287 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IDA
  original_reference_id: PMID:17989287
  qualifier: is_active_in
  review:
    summary: >-
      glutamatergic synapse is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0098978 (glutamatergic synapse), the IDA annotation with qualifier is_active_in
      from PMID:17989287 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0098978
    label: glutamatergic synapse
  evidence_type: IMP
  original_reference_id: PMID:17989287
  qualifier: is_active_in
  review:
    summary: >-
      glutamatergic synapse is retained as a non-core cellular-component/localization
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0098978 (glutamatergic synapse), the IMP annotation with qualifier is_active_in
      from PMID:17989287 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0099171
    label: presynaptic modulation of chemical synaptic transmission
  evidence_type: EXP
  original_reference_id: PMID:17989287
  qualifier: involved_in
  review:
    summary: >-
      presynaptic modulation of chemical synaptic transmission is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the
      EXP annotation with qualifier involved_in from PMID:17989287 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0099171
    label: presynaptic modulation of chemical synaptic transmission
  evidence_type: IDA
  original_reference_id: PMID:17989287
  qualifier: involved_in
  review:
    summary: >-
      presynaptic modulation of chemical synaptic transmission is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the
      IDA annotation with qualifier involved_in from PMID:17989287 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0099171
    label: presynaptic modulation of chemical synaptic transmission
  evidence_type: IMP
  original_reference_id: PMID:17989287
  qualifier: involved_in
  review:
    summary: >-
      presynaptic modulation of chemical synaptic transmission is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0099171 (presynaptic modulation of chemical synaptic transmission), the
      IMP annotation with qualifier involved_in from PMID:17989287 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0007005
    label: mitochondrion organization
  evidence_type: IMP
  original_reference_id: PMID:25118933
  qualifier: involved_in
  review:
    summary: >-
      mitochondrion organization is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0007005 (mitochondrion organization), the IMP annotation with qualifier
      involved_in from PMID:25118933 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030336
    label: negative regulation of cell migration
  evidence_type: IDA
  original_reference_id: PMID:27494834
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of cell migration is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030336 (negative regulation of cell migration), the IDA annotation with
      qualifier involved_in from PMID:27494834 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0060070
    label: canonical Wnt signaling pathway
  evidence_type: IDA
  original_reference_id: PMID:16890161
  qualifier: involved_in
  review:
    summary: >-
      canonical Wnt signaling pathway is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0060070 (canonical Wnt signaling pathway), the IDA annotation with qualifier
      involved_in from PMID:16890161 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0045668
    label: negative regulation of osteoblast differentiation
  evidence_type: IMP
  original_reference_id: PMID:24023731
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of osteoblast differentiation is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0045668 (negative regulation of osteoblast differentiation), the IMP
      annotation with qualifier involved_in from PMID:24023731 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  evidence_type: IDA
  original_reference_id: PMID:22660580
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of proteasomal ubiquitin-dependent protein catabolic process
      is retained as a core biological-process annotation for GSK3B; it captures process
      participation within the synthesized core biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein
      catabolic process), the IDA annotation with qualifier involved_in from PMID:22660580
      is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0019082
    label: viral protein processing
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9694631
  qualifier: involved_in
  review:
    summary: >-
      viral protein processing is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0019082 (viral protein processing), the TAS annotation with qualifier
      involved_in from Reactome:R-HSA-9694631 supports retaining the annotation, but
      the term describes a context-specific outcome or peripheral branch rather than
      the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:29142209
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:29142209 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0031398
    label: positive regulation of protein ubiquitination
  evidence_type: IDA
  original_reference_id: PMID:29142209
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein ubiquitination is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0031398 (positive regulation of protein ubiquitination), the IDA annotation
      with qualifier involved_in from PMID:29142209 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0097191
    label: extrinsic apoptotic signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      extrinsic apoptotic signaling pathway is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0097191 (extrinsic apoptotic signaling pathway), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of gene expression is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010628 (positive regulation of gene expression), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:28992046
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:28992046 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0045724
    label: positive regulation of cilium assembly
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of cilium assembly is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0045724 (positive regulation of cilium assembly), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1903566
    label: positive regulation of protein localization to cilium
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein localization to cilium is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1903566 (positive regulation of protein localization to cilium), the
      ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0106310
    label: protein serine kinase activity
  evidence_type: IGI
  original_reference_id: PMID:30556160
  qualifier: enables
  review:
    summary: >-
      protein serine kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0106310 (protein serine kinase activity), the IGI annotation with qualifier
      enables from PMID:30556160 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:26315788
  qualifier: acts_upstream_of
  review:
    summary: >-
      positive regulation of gene expression is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010628 (positive regulation of gene expression), the IMP annotation
      with qualifier acts_upstream_of from PMID:26315788 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010628
    label: positive regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:27050373
  qualifier: acts_upstream_of
  review:
    summary: >-
      positive regulation of gene expression is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010628 (positive regulation of gene expression), the IMP annotation
      with qualifier acts_upstream_of from PMID:27050373 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:27050373
  qualifier: acts_upstream_of
  review:
    summary: >-
      negative regulation of gene expression is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010629 (negative regulation of gene expression), the IMP annotation
      with qualifier acts_upstream_of from PMID:27050373 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: IGI
  original_reference_id: PMID:27846906
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      IGI annotation with qualifier involved_in from PMID:27846906 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0010629
    label: negative regulation of gene expression
  evidence_type: IMP
  original_reference_id: PMID:28122350
  qualifier: acts_upstream_of
  review:
    summary: >-
      negative regulation of gene expression is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010629 (negative regulation of gene expression), the IMP annotation
      with qualifier acts_upstream_of from PMID:28122350 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0045597
    label: positive regulation of cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:28122350
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of cell differentiation is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0045597 (positive regulation of cell differentiation), the IMP annotation
      with qualifier involved_in from PMID:28122350 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0071300
    label: cellular response to retinoic acid
  evidence_type: IMP
  original_reference_id: PMID:28122350
  qualifier: involved_in
  review:
    summary: >-
      cellular response to retinoic acid is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0071300 (cellular response to retinoic acid), the IMP annotation with
      qualifier involved_in from PMID:28122350 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:2000740
    label: negative regulation of mesenchymal stem cell differentiation
  evidence_type: IMP
  original_reference_id: PMID:24023731
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of mesenchymal stem cell differentiation is retained as
      a non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:2000740 (negative regulation of mesenchymal stem cell differentiation),
      the IMP annotation with qualifier involved_in from PMID:24023731 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:19364825
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:19364825 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  evidence_type: IDA
  original_reference_id: PMID:19364825
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of proteasomal ubiquitin-dependent protein catabolic process
      is retained as a core biological-process annotation for GSK3B; it captures process
      participation within the synthesized core biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein
      catabolic process), the IDA annotation with qualifier involved_in from PMID:19364825
      is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:18846110
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:18846110 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1902042
    label: negative regulation of extrinsic apoptotic signaling pathway via 
      death domain receptors
  evidence_type: IMP
  original_reference_id: PMID:18846110
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of extrinsic apoptotic signaling pathway via death domain
      receptors is retained as a non-core biological-process annotation for GSK3B;
      it records a supported context, interaction, localization, or pathway branch
      that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway
      via death domain receptors), the IMP annotation with qualifier involved_in from
      PMID:18846110 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:31073040
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:31073040 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0150101
    label: regulation of microtubule anchoring at centrosome
  evidence_type: IMP
  original_reference_id: PMID:17139249
  qualifier: involved_in
  review:
    summary: >-
      regulation of microtubule anchoring at centrosome is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0150101 (regulation of microtubule anchoring at centrosome), the IMP
      annotation with qualifier involved_in from PMID:17139249 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0010508
    label: positive regulation of autophagy
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of autophagy is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0010508 (positive regulation of autophagy), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0042752
    label: regulation of circadian rhythm
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of circadian rhythm is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0042752 (regulation of circadian rhythm), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1900271
    label: regulation of long-term synaptic potentiation
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of long-term synaptic potentiation is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1900271 (regulation of long-term synaptic potentiation), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0106027
    label: neuron projection organization
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      neuron projection organization is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0106027 (neuron projection organization), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28903391
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:28903391 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0048156
    label: tau protein binding
  evidence_type: NAS
  original_reference_id: PMID:28386764
  qualifier: enables
  review:
    summary: >-
      tau protein binding is retained as a core molecular-function annotation for
      GSK3B; it captures activity or binding specificity within the synthesized core
      biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0048156 (tau protein binding), the NAS annotation with qualifier enables
      from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0050321
    label: tau-protein kinase activity
  evidence_type: NAS
  original_reference_id: PMID:28386764
  qualifier: enables
  review:
    summary: >-
      tau-protein kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0050321 (tau-protein kinase activity), the NAS annotation with qualifier
      enables from PMID:28386764 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: IC
  original_reference_id: PMID:9601641
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      IC annotation with qualifier involved_in from PMID:9601641 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: IMP
  original_reference_id: PMID:16981698
  qualifier: enables
  review:
    summary: >-
      protein kinase activity is directionally related to GSK3B biology but is not
      the best curation target; protein serine/threonine kinase activity better captures
      the specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0004672 (protein kinase activity), the IMP annotation with qualifier
      enables from PMID:16981698 supports a relationship to GSK3B, but the current
      term is less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IMP
  original_reference_id: PMID:16981698
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IMP annotation
      with qualifier enables from PMID:16981698 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:16981698
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:16981698 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IMP
  original_reference_id: PMID:16981698
  qualifier: involved_in
  review:
    summary: >-
      protein phosphorylation is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0006468 (protein phosphorylation), the IMP annotation with qualifier
      involved_in from PMID:16981698 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      ISS annotation with qualifier involved_in from GO_REF:0000024 is consistent
      with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of
      primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau,
      and protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:28829046
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:28829046 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030010
    label: establishment of cell polarity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      establishment of cell polarity is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030010 (establishment of cell polarity), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030010
    label: establishment of cell polarity
  evidence_type: TAS
  original_reference_id: PMID:18268107
  qualifier: involved_in
  review:
    summary: >-
      establishment of cell polarity is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030010 (establishment of cell polarity), the TAS annotation with qualifier
      involved_in from PMID:18268107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030011
    label: maintenance of cell polarity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      maintenance of cell polarity is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030011 (maintenance of cell polarity), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030011
    label: maintenance of cell polarity
  evidence_type: TAS
  original_reference_id: PMID:18268107
  qualifier: involved_in
  review:
    summary: >-
      maintenance of cell polarity is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030011 (maintenance of cell polarity), the TAS annotation with qualifier
      involved_in from PMID:18268107 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030424
    label: axon
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: located_in
  review:
    summary: >-
      axon is retained as a non-core cellular-component/localization annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030424 (axon), the ISS annotation with qualifier located_in from GO_REF:0000024
      supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030425
    label: dendrite
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: located_in
  review:
    summary: >-
      dendrite is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030425 (dendrite), the ISS annotation with qualifier located_in from
      GO_REF:0000024 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030516
    label: regulation of axon extension
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of axon extension is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0030516 (regulation of axon extension), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0048814
    label: regulation of dendrite morphogenesis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of dendrite morphogenesis is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0048814 (regulation of dendrite morphogenesis), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0050770
    label: regulation of axonogenesis
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of axonogenesis is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0050770 (regulation of axonogenesis), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0070507
    label: regulation of microtubule cytoskeleton organization
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      regulation of microtubule cytoskeleton organization is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0070507 (regulation of microtubule cytoskeleton organization), the ISS
      annotation with qualifier involved_in from GO_REF:0000024 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: NAS
  original_reference_id: PMID:28386764
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the NAS annotation
      with qualifier enables from PMID:28386764 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0060079
    label: excitatory postsynaptic potential
  evidence_type: NAS
  original_reference_id: PMID:21711983
  qualifier: involved_in
  review:
    summary: >-
      excitatory postsynaptic potential is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0060079 (excitatory postsynaptic potential), the NAS annotation with
      qualifier involved_in from PMID:21711983 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25897075
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:25897075 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  evidence_type: IMP
  original_reference_id: PMID:25897075
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of proteasomal ubiquitin-dependent protein catabolic process
      is retained as a core biological-process annotation for GSK3B; it captures process
      participation within the synthesized core biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein
      catabolic process), the IMP annotation with qualifier involved_in from PMID:25897075
      is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:17139249
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:17139249 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0034452
    label: dynactin binding
  evidence_type: IPI
  original_reference_id: PMID:17139249
  qualifier: enables
  review:
    summary: >-
      dynactin binding is retained as a non-core molecular-function annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0034452 (dynactin binding), the IPI annotation with qualifier enables
      from PMID:17139249 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1904781
    label: positive regulation of protein localization to centrosome
  evidence_type: IMP
  original_reference_id: PMID:17139249
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein localization to centrosome is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1904781 (positive regulation of protein localization to centrosome),
      the IMP annotation with qualifier involved_in from PMID:17139249 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005813
    label: centrosome
  evidence_type: IDA
  original_reference_id: PMID:17139249
  qualifier: located_in
  review:
    summary: >-
      centrosome is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005813 (centrosome), the IDA annotation with qualifier located_in from
      PMID:17139249 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: NAS
  original_reference_id: PMID:8725894
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the NAS annotation
      with qualifier enables from PMID:8725894 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:1904646
    label: cellular response to amyloid-beta
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      cellular response to amyloid-beta is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1904646 (cellular response to amyloid-beta), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:20007971
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:20007971 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0031175
    label: neuron projection development
  evidence_type: IDA
  original_reference_id: PMID:19830702
  qualifier: involved_in
  review:
    summary: >-
      neuron projection development is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0031175 (neuron projection development), the IDA annotation with qualifier
      involved_in from PMID:19830702 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:25920809
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:25920809 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:27484798
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:27484798 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0002020
    label: protease binding
  evidence_type: IPI
  original_reference_id: PMID:25118933
  qualifier: enables
  review:
    summary: >-
      protease binding is retained as a non-core molecular-function annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0002020 (protease binding), the IPI annotation with qualifier enables
      from PMID:25118933 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: TAS
  original_reference_id: PMID:26049140
  qualifier: enables
  review:
    summary: >-
      protein kinase activity is directionally related to GSK3B biology but is not
      the best curation target; protein serine/threonine kinase activity better captures
      the specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0004672 (protein kinase activity), the TAS annotation with qualifier
      enables from PMID:26049140 supports a relationship to GSK3B, but the current
      term is less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: TAS
  original_reference_id: PMID:26049140
  qualifier: involved_in
  review:
    summary: >-
      intracellular signal transduction is marked over-annotated for GSK3B because
      this biological-process term is too generic, interaction-map-like, or weakly
      informative relative to the gene-specific biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0035556 (intracellular signal transduction), the TAS annotation with
      qualifier involved_in from PMID:26049140 may reflect a real assay result or
      interaction, but this GO term does not identify the specific kinase/substrate,
      pathway, or localization annotation that explains GSK3B's role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific
      annotations are present, so this is marked over-annotated rather than accepted
      as a core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1904339
    label: negative regulation of dopaminergic neuron differentiation
  evidence_type: TAS
  original_reference_id: PMID:24431302
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of dopaminergic neuron differentiation is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1904339 (negative regulation of dopaminergic neuron differentiation),
      the TAS annotation with qualifier involved_in from PMID:24431302 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: TAS
  original_reference_id: PMID:22988876
  qualifier: enables
  review:
    summary: >-
      protein kinase activity is directionally related to GSK3B biology but is not
      the best curation target; protein serine/threonine kinase activity better captures
      the specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0004672 (protein kinase activity), the TAS annotation with qualifier
      enables from PMID:22988876 supports a relationship to GSK3B, but the current
      term is less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004672
    label: protein kinase activity
  evidence_type: TAS
  original_reference_id: PMID:24115276
  qualifier: enables
  review:
    summary: >-
      protein kinase activity is directionally related to GSK3B biology but is not
      the best curation target; protein serine/threonine kinase activity better captures
      the specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0004672 (protein kinase activity), the TAS annotation with qualifier
      enables from PMID:24115276 supports a relationship to GSK3B, but the current
      term is less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:1990909
    label: Wnt signalosome
  evidence_type: TAS
  original_reference_id: PMID:24115276
  qualifier: part_of
  review:
    summary: >-
      Wnt signalosome is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:1990909 (Wnt signalosome), the TAS annotation with qualifier part_of
      from PMID:24115276 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11955436
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:11955436 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: TAS
  original_reference_id: PMID:11955436
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the TAS annotation with qualifier
      part_of from PMID:11955436 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  evidence_type: IC
  original_reference_id: PMID:11955436
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of proteasomal ubiquitin-dependent protein catabolic process
      is retained as a core biological-process annotation for GSK3B; it captures process
      participation within the synthesized core biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein
      catabolic process), the IC annotation with qualifier involved_in from PMID:11955436
      is consistent with GSK3B's core role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: IC
  original_reference_id: PMID:11955436
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      IC annotation with qualifier involved_in from PMID:11955436 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:16315267
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:16315267 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9762094
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9762094 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9824995
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9824995 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9824999
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9824999 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9943675
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9943675 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9008555
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from
      Reactome:R-NUL-9008555 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005654
    label: nucleoplasm
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-9008636
  qualifier: located_in
  review:
    summary: >-
      nucleoplasm is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005654 (nucleoplasm), the TAS annotation with qualifier located_in from
      Reactome:R-NUL-9008636 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:1900181
    label: negative regulation of protein localization to nucleus
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of protein localization to nucleus is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1900181 (negative regulation of protein localization to nucleus), the
      ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:24391509
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:24391509 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IDA
  original_reference_id: PMID:24391509
  qualifier: enables
  review:
    summary: >-
      kinase activity is directionally related to GSK3B biology but is not the best
      curation target; protein serine/threonine kinase activity better captures the
      specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0016301 (kinase activity), the IDA annotation with qualifier enables
      from PMID:24391509 supports a relationship to GSK3B, but the current term is
      less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:19706605
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:19706605 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0046777
    label: protein autophosphorylation
  evidence_type: IDA
  original_reference_id: PMID:23184662
  qualifier: involved_in
  review:
    summary: >-
      protein autophosphorylation is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0046777 (protein autophosphorylation), the IDA annotation with qualifier
      involved_in from PMID:23184662 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5339713
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-5339713 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0036016
    label: cellular response to interleukin-3
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      cellular response to interleukin-3 is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0036016 (cellular response to interleukin-3), the ISS annotation with
      qualifier involved_in from GO_REF:0000024 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0097192
    label: extrinsic apoptotic signaling pathway in absence of ligand
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      extrinsic apoptotic signaling pathway in absence of ligand is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand),
      the ISS annotation with qualifier involved_in from GO_REF:0000024 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:1901030
    label: positive regulation of mitochondrial outer membrane permeabilization 
      involved in apoptotic signaling pathway
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of mitochondrial outer membrane permeabilization involved
      in apoptotic signaling pathway is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:1901030 (positive regulation of mitochondrial outer membrane permeabilization
      involved in apoptotic signaling pathway), the ISS annotation with qualifier
      involved_in from GO_REF:0000024 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2399966
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-2399966 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-1504186
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-1504186 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195251
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195251 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195275
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195275 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195280
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195280 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195283
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195283 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195287
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195287 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195300
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195300 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195304
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195304 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-195318
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-195318 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-201677
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-201677 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-201685
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-201685 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2130279
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-2130279 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2130282
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-2130282 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-2130286
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-2130286 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-3371435
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-3371435 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-399951
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-399951 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4791278
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4791278 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4827388
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4827388 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4839634
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4839634 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4839635
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4839635 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4839638
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4839638 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4839734
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4839734 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-4839746
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-4839746 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5229343
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-5229343 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5323526
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-5323526 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5368596
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-5368596 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-5610732
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-5610732 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9683664
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9683664 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9687724
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9687724 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-HSA-9729260
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-HSA-9729260 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-1458902
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-NUL-1458902 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005829
    label: cytosol
  evidence_type: TAS
  original_reference_id: Reactome:R-NUL-209146
  qualifier: located_in
  review:
    summary: >-
      cytosol is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005829 (cytosol), the TAS annotation with qualifier located_in from
      Reactome:R-NUL-209146 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0007623
    label: circadian rhythm
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      circadian rhythm is retained as a non-core biological-process annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0007623 (circadian rhythm), the ISS annotation with qualifier involved_in
      from GO_REF:0000024 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0032092
    label: positive regulation of protein binding
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein binding is marked over-annotated for GSK3B because
      this biological-process term is too generic, interaction-map-like, or weakly
      informative relative to the gene-specific biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0032092 (positive regulation of protein binding), the ISS annotation
      with qualifier involved_in from GO_REF:0000024 may reflect a real assay result
      or interaction, but this GO term does not identify the specific kinase/substrate,
      pathway, or localization annotation that explains GSK3B's role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific
      annotations are present, so this is marked over-annotated rather than accepted
      as a core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:9072970
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:9072970 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: TAS
  original_reference_id: PMID:19366350
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the TAS annotation with qualifier
      part_of from PMID:19366350 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0045719
    label: negative regulation of glycogen biosynthetic process
  evidence_type: TAS
  original_reference_id: PMID:19366350
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of glycogen biosynthetic process is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0045719 (negative regulation of glycogen biosynthetic process), the TAS
      annotation with qualifier involved_in from PMID:19366350 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0050321
    label: tau-protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:14690523
  qualifier: enables
  review:
    summary: >-
      tau-protein kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0050321 (tau-protein kinase activity), the IDA annotation with qualifier
      enables from PMID:14690523 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0070885
    label: negative regulation of calcineurin-NFAT signaling cascade
  evidence_type: IMP
  original_reference_id: PMID:9072970
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of calcineurin-NFAT signaling cascade is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0070885 (negative regulation of calcineurin-NFAT signaling cascade),
      the IMP annotation with qualifier involved_in from PMID:9072970 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  evidence_type: TAS
  original_reference_id: PMID:19366350
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of canonical Wnt signaling pathway is retained as a core
      biological-process annotation for GSK3B; it captures process participation within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0090090 (negative regulation of canonical Wnt signaling pathway), the
      TAS annotation with qualifier involved_in from PMID:19366350 is consistent with
      GSK3B's core role in ATP-dependent serine/threonine phosphorylation of primed
      protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and
      protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:2000077
    label: negative regulation of type B pancreatic cell development
  evidence_type: TAS
  original_reference_id: PMID:19366350
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of type B pancreatic cell development is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:2000077 (negative regulation of type B pancreatic cell development),
      the TAS annotation with qualifier involved_in from PMID:19366350 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:2000466
    label: negative regulation of glycogen (starch) synthase activity
  evidence_type: TAS
  original_reference_id: PMID:19366350
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of glycogen (starch) synthase activity is retained as a
      core biological-process annotation for GSK3B; it captures process participation
      within the synthesized core biology: GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:2000466 (negative regulation of glycogen (starch) synthase activity),
      the TAS annotation with qualifier involved_in from PMID:19366350 is consistent
      with GSK3B's core role in ATP-dependent serine/threonine phosphorylation of
      primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin, tau,
      and protein-turnover substrates. This action keeps the term because it provides
      a specific, evidence-backed kinase/substrate, pathway, or localization annotation
      rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:18348280
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:18348280 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0019901
    label: protein kinase binding
  evidence_type: IPI
  original_reference_id: PMID:18348280
  qualifier: enables
  review:
    summary: >-
      protein kinase binding is retained as a non-core molecular-function annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0019901 (protein kinase binding), the IPI annotation with qualifier enables
      from PMID:18348280 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005813
    label: centrosome
  evidence_type: IDA
  original_reference_id: PMID:21399614
  qualifier: located_in
  review:
    summary: >-
      centrosome is retained as a non-core cellular-component/localization annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0005813 (centrosome), the IDA annotation with qualifier located_in from
      PMID:21399614 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:20937854
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
      PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005886
    label: plasma membrane
  evidence_type: IDA
  original_reference_id: PMID:20937854
  qualifier: located_in
  review:
    summary: >-
      plasma membrane is retained as a core cellular-component/localization annotation
      for GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005886 (plasma membrane), the IDA annotation with qualifier located_in
      from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0006468
    label: protein phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:20937854
  qualifier: involved_in
  review:
    summary: >-
      protein phosphorylation is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0006468 (protein phosphorylation), the IDA annotation with qualifier
      involved_in from PMID:20937854 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0032886
    label: regulation of microtubule-based process
  evidence_type: IMP
  original_reference_id: PMID:20937854
  qualifier: involved_in
  review:
    summary: >-
      regulation of microtubule-based process is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0032886 (regulation of microtubule-based process), the IMP annotation
      with qualifier involved_in from PMID:20937854 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9731200
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:9731200 may reflect a real assay result or interaction, but this GO
      term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0061629
    label: RNA polymerase II-specific DNA-binding transcription factor binding
  evidence_type: IPI
  original_reference_id: PMID:20864106
  qualifier: enables
  review:
    summary: >-
      RNA polymerase II-specific DNA-binding transcription factor binding is retained
      as a non-core molecular-function annotation for GSK3B; it records a supported
      context, interaction, localization, or pathway branch that is secondary to GSK3B
      catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0061629 (RNA polymerase II-specific DNA-binding transcription factor
      binding), the IPI annotation with qualifier enables from PMID:20864106 supports
      retaining the annotation, but the term describes a context-specific outcome
      or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0031625
    label: ubiquitin protein ligase binding
  evidence_type: IPI
  original_reference_id: PMID:21118991
  qualifier: enables
  review:
    summary: >-
      ubiquitin protein ligase binding is retained as a non-core molecular-function
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0031625 (ubiquitin protein ligase binding), the IPI annotation with qualifier
      enables from PMID:21118991 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0002039
    label: p53 binding
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: enables
  review:
    summary: >-
      p53 binding is retained as a non-core molecular-function annotation for GSK3B;
      it records a supported context, interaction, localization, or pathway branch
      that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0002039 (p53 binding), the IDA annotation with qualifier enables from
      PMID:14744935 supports retaining the annotation, but the term describes a context-specific
      outcome or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:14744935 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from
      PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
      PMID:14744935 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0006983
    label: ER overload response
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: acts_upstream_of_or_within
  review:
    summary: >-
      ER overload response is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0006983 (ER overload response), the IDA annotation with qualifier acts_upstream_of_or_within
      from PMID:14744935 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: acts_upstream_of_or_within
  review:
    summary: >-
      peptidyl-serine phosphorylation is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0018105 (peptidyl-serine phosphorylation), the IDA annotation with qualifier
      acts_upstream_of_or_within from PMID:14744935 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0043066
    label: negative regulation of apoptotic process
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: acts_upstream_of_or_within
  review:
    summary: >-
      negative regulation of apoptotic process is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0043066 (negative regulation of apoptotic process), the IDA annotation
      with qualifier acts_upstream_of_or_within from PMID:14744935 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0046827
    label: positive regulation of protein export from nucleus
  evidence_type: IDA
  original_reference_id: PMID:14744935
  qualifier: acts_upstream_of_or_within
  review:
    summary: >-
      positive regulation of protein export from nucleus is retained as a non-core
      biological-process annotation for GSK3B; it records a supported context, interaction,
      localization, or pathway branch that is secondary to GSK3B catalytic kinase
      activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling,
      glycogen/insulin regulation, tau phosphorylation, protein-turnover control,
      and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0046827 (positive regulation of protein export from nucleus), the IDA
      annotation with qualifier acts_upstream_of_or_within from PMID:14744935 supports
      retaining the annotation, but the term describes a context-specific outcome
      or peripheral branch rather than the principal GSK3B function: ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. Keeping it as non-core
      prevents broad pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0001837
    label: epithelial to mesenchymal transition
  evidence_type: IMP
  original_reference_id: PMID:15448698
  qualifier: involved_in
  review:
    summary: >-
      epithelial to mesenchymal transition is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0001837 (epithelial to mesenchymal transition), the IMP annotation with
      qualifier involved_in from PMID:15448698 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:15448698
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:15448698 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005634
    label: nucleus
  evidence_type: IDA
  original_reference_id: PMID:15448698
  qualifier: located_in
  review:
    summary: >-
      nucleus is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005634 (nucleus), the IDA annotation with qualifier located_in from
      PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:15448698
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
      PMID:15448698 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0016301
    label: kinase activity
  evidence_type: IDA
  original_reference_id: PMID:15448698
  qualifier: enables
  review:
    summary: >-
      kinase activity is directionally related to GSK3B biology but is not the best
      curation target; protein serine/threonine kinase activity better captures the
      specific supported function or process.
    action: MODIFY
    reason: >-
      For GO:0016301 (kinase activity), the IDA annotation with qualifier enables
      from PMID:15448698 supports a relationship to GSK3B, but the current term is
      less precise than protein serine/threonine kinase activity for the evidence
      and for the synthesized core/non-core role of GSK3B. The MODIFY action preserves
      the biological intent while pointing curators to the more informative GO term.
    proposed_replacement_terms:
    - id: GO:0004674
      label: protein serine/threonine kinase activity
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0050321
    label: tau-protein kinase activity
  evidence_type: IDA
  original_reference_id: PMID:16365045
  qualifier: enables
  review:
    summary: >-
      tau-protein kinase activity is retained as a core molecular-function annotation
      for GSK3B; it captures activity or binding specificity within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0050321 (tau-protein kinase activity), the IDA annotation with qualifier
      enables from PMID:16365045 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0031333
    label: negative regulation of protein-containing complex assembly
  evidence_type: IMP
  original_reference_id: PMID:16188939
  qualifier: involved_in
  review:
    summary: >-
      negative regulation of protein-containing complex assembly is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0031333 (negative regulation of protein-containing complex assembly),
      the IMP annotation with qualifier involved_in from PMID:16188939 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:19038973
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
      PMID:19038973 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0021766
    label: hippocampus development
  evidence_type: IMP
  original_reference_id: PMID:19581563
  qualifier: involved_in
  review:
    summary: >-
      hippocampus development is retained as a non-core biological-process annotation
      for GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0021766 (hippocampus development), the IMP annotation with qualifier
      involved_in from PMID:19581563 supports retaining the annotation, but the term
      describes a context-specific outcome or peripheral branch rather than the principal
      GSK3B function: ATP-dependent serine/threonine phosphorylation of primed protein
      substrates, especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover
      substrates. Keeping it as non-core prevents broad pathway participation from
      being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0071109
    label: superior temporal gyrus development
  evidence_type: IMP
  original_reference_id: PMID:19581563
  qualifier: involved_in
  review:
    summary: >-
      superior temporal gyrus development is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0071109 (superior temporal gyrus development), the IMP annotation with
      qualifier involved_in from PMID:19581563 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0001954
    label: positive regulation of cell-matrix adhesion
  evidence_type: IMP
  original_reference_id: PMID:18156211
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of cell-matrix adhesion is retained as a non-core biological-process
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0001954 (positive regulation of cell-matrix adhesion), the IMP annotation
      with qualifier involved_in from PMID:18156211 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: IDA
  original_reference_id: PMID:16188939
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier
      part_of from PMID:16188939 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0045732
    label: positive regulation of protein catabolic process
  evidence_type: IC
  original_reference_id: PMID:16188939
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein catabolic process is retained as a core biological-process
      annotation for GSK3B; it captures process participation within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0045732 (positive regulation of protein catabolic process), the IC annotation
      with qualifier involved_in from PMID:16188939 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005737
    label: cytoplasm
  evidence_type: IDA
  original_reference_id: PMID:18787224
  qualifier: located_in
  review:
    summary: >-
      cytoplasm is retained as a core cellular-component/localization annotation for
      GSK3B; it captures site of action or component context within the synthesized
      core biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005737 (cytoplasm), the IDA annotation with qualifier located_in from
      PMID:18787224 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11035810
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:11035810 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0034236
    label: protein kinase A catalytic subunit binding
  evidence_type: IPI
  original_reference_id: PMID:11035810
  qualifier: enables
  review:
    summary: >-
      protein kinase A catalytic subunit binding is retained as a non-core molecular-function
      annotation for GSK3B; it records a supported context, interaction, localization,
      or pathway branch that is secondary to GSK3B catalytic kinase activity, substrate
      phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0034236 (protein kinase A catalytic subunit binding), the IPI annotation
      with qualifier enables from PMID:11035810 supports retaining the annotation,
      but the term describes a context-specific outcome or peripheral branch rather
      than the principal GSK3B function: ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:8638126
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:8638126 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005977
    label: glycogen metabolic process
  evidence_type: IDA
  original_reference_id: PMID:8638126
  qualifier: involved_in
  review:
    summary: >-
      glycogen metabolic process is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0005977 (glycogen metabolic process), the IDA annotation with qualifier
      involved_in from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0008013
    label: beta-catenin binding
  evidence_type: IPI
  original_reference_id: PMID:8638126
  qualifier: enables
  review:
    summary: >-
      beta-catenin binding is retained as a core molecular-function annotation for
      GSK3B; it captures activity or binding specificity within the synthesized core
      biology: GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0008013 (beta-catenin binding), the IPI annotation with qualifier enables
      from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. This action keeps the term because it
      provides a specific, evidence-backed kinase/substrate, pathway, or localization
      annotation rather than only a downstream phenotype or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: IDA
  original_reference_id: PMID:8638126
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier
      part_of from PMID:8638126 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0031334
    label: positive regulation of protein-containing complex assembly
  evidence_type: IDA
  original_reference_id: PMID:8638126
  qualifier: involved_in
  review:
    summary: >-
      positive regulation of protein-containing complex assembly is retained as a
      non-core biological-process annotation for GSK3B; it records a supported context,
      interaction, localization, or pathway branch that is secondary to GSK3B catalytic
      kinase activity, substrate phosphorylation, Wnt/beta-catenin destruction-complex
      signaling, glycogen/insulin regulation, tau phosphorylation, protein-turnover
      control, and the cytosolic/nuclear sites where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0031334 (positive regulation of protein-containing complex assembly),
      the IDA annotation with qualifier involved_in from PMID:8638126 supports retaining
      the annotation, but the term describes a context-specific outcome or peripheral
      branch rather than the principal GSK3B function: ATP-dependent serine/threonine
      phosphorylation of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. Keeping it as non-core prevents broad
      pathway participation from being promoted to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: ISS
  original_reference_id: GO_REF:0000024
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the ISS annotation
      with qualifier enables from GO_REF:0000024 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9482734
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:9482734 may reflect a real assay result or interaction, but this GO
      term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  evidence_type: IDA
  original_reference_id: PMID:11104755
  qualifier: enables
  review:
    summary: >-
      protein serine/threonine kinase activity is retained as a core molecular-function
      annotation for GSK3B; it captures activity or binding specificity within the
      synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0004674 (protein serine/threonine kinase activity), the IDA annotation
      with qualifier enables from PMID:11104755 is consistent with GSK3B's core role
      in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0018105
    label: peptidyl-serine phosphorylation
  evidence_type: IDA
  original_reference_id: PMID:11104755
  qualifier: acts_upstream_of_or_within
  review:
    summary: >-
      peptidyl-serine phosphorylation is retained as a core biological-process annotation
      for GSK3B; it captures process participation within the synthesized core biology:
      GSK3B catalytic kinase activity, substrate phosphorylation, Wnt/beta-catenin
      destruction-complex signaling, glycogen/insulin regulation, tau phosphorylation,
      protein-turnover control, and the cytosolic/nuclear sites where these reactions
      occur.
    action: ACCEPT
    reason: >-
      For GO:0018105 (peptidyl-serine phosphorylation), the IDA annotation with qualifier
      acts_upstream_of_or_within from PMID:11104755 is consistent with GSK3B's core
      role in ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      This action keeps the term because it provides a specific, evidence-backed kinase/substrate,
      pathway, or localization annotation rather than only a downstream phenotype
      or generic interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0035556
    label: intracellular signal transduction
  evidence_type: IDA
  original_reference_id: PMID:14749367
  qualifier: acts_upstream_of_or_within
  review:
    summary: >-
      intracellular signal transduction is marked over-annotated for GSK3B because
      this biological-process term is too generic, interaction-map-like, or weakly
      informative relative to the gene-specific biology: GSK3B catalytic kinase activity,
      substrate phosphorylation, Wnt/beta-catenin destruction-complex signaling, glycogen/insulin
      regulation, tau phosphorylation, protein-turnover control, and the cytosolic/nuclear
      sites where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0035556 (intracellular signal transduction), the IDA annotation with
      qualifier acts_upstream_of_or_within from PMID:14749367 may reflect a real assay
      result or interaction, but this GO term does not identify the specific kinase/substrate,
      pathway, or localization annotation that explains GSK3B's role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. More informative gene-specific
      annotations are present, so this is marked over-annotated rather than accepted
      as a core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:9601641
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:9601641 may reflect a real assay result or interaction, but this GO
      term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0030877
    label: beta-catenin destruction complex
  evidence_type: IDA
  original_reference_id: PMID:9601641
  qualifier: part_of
  review:
    summary: >-
      beta-catenin destruction complex is retained as a core cellular-component/localization
      annotation for GSK3B; it captures site of action or component context within
      the synthesized core biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: ACCEPT
    reason: >-
      For GO:0030877 (beta-catenin destruction complex), the IDA annotation with qualifier
      part_of from PMID:9601641 is consistent with GSK3B's core role in ATP-dependent
      serine/threonine phosphorylation of primed protein substrates, especially Wnt/beta-catenin,
      glycogen/insulin, tau, and protein-turnover substrates. This action keeps the
      term because it provides a specific, evidence-backed kinase/substrate, pathway,
      or localization annotation rather than only a downstream phenotype or generic
      interaction label.
    additional_reference_ids:
    - PMID:14690523
    - PMID:8638126
    - PMID:11955436
    - file:human/GSK3B/GSK3B-uniprot.txt
- term:
    id: GO:0005515
    label: protein binding
  evidence_type: IPI
  original_reference_id: PMID:12927815
  qualifier: enables
  review:
    summary: >-
      protein binding is marked over-annotated for GSK3B because this molecular-function
      term is too generic, interaction-map-like, or weakly informative relative to
      the gene-specific biology: GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: MARK_AS_OVER_ANNOTATED
    reason: >-
      For GO:0005515 (protein binding), the IPI annotation with qualifier enables
      from PMID:12927815 may reflect a real assay result or interaction, but this
      GO term does not identify the specific kinase/substrate, pathway, or localization
      annotation that explains GSK3B's role in ATP-dependent serine/threonine phosphorylation
      of primed protein substrates, especially Wnt/beta-catenin, glycogen/insulin,
      tau, and protein-turnover substrates. More informative gene-specific annotations
      are present, so this is marked over-annotated rather than accepted as a core
      function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-notes.md
- term:
    id: GO:0051059
    label: NF-kappaB binding
  evidence_type: IPI
  original_reference_id: PMID:15465828
  qualifier: enables
  review:
    summary: >-
      NF-kappaB binding is retained as a non-core molecular-function annotation for
      GSK3B; it records a supported context, interaction, localization, or pathway
      branch that is secondary to GSK3B catalytic kinase activity, substrate phosphorylation,
      Wnt/beta-catenin destruction-complex signaling, glycogen/insulin regulation,
      tau phosphorylation, protein-turnover control, and the cytosolic/nuclear sites
      where these reactions occur.
    action: KEEP_AS_NON_CORE
    reason: >-
      For GO:0051059 (NF-kappaB binding), the IPI annotation with qualifier enables
      from PMID:15465828 supports retaining the annotation, but the term describes
      a context-specific outcome or peripheral branch rather than the principal GSK3B
      function: ATP-dependent serine/threonine phosphorylation of primed protein substrates,
      especially Wnt/beta-catenin, glycogen/insulin, tau, and protein-turnover substrates.
      Keeping it as non-core prevents broad pathway participation from being promoted
      to core function.
    additional_reference_ids:
    - file:human/GSK3B/GSK3B-uniprot.txt
    - file:human/GSK3B/GSK3B-notes.md
references:
- id: GO_REF:0000002
  title: Gene Ontology annotation through association of InterPro records with 
    GO terms
  findings: []
- id: GO_REF:0000024
  title: Manual transfer of experimentally-verified manual GO annotation data to
    orthologs by curator judgment of sequence similarity
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      High-use curator-reviewed orthology-transfer provenance for GSK3B annotations;
      retained as propagated evidence rather than direct experimental support. Action
      counts in this review: {'KEEP_AS_NON_CORE': 23, 'ACCEPT': 3, 'MARK_AS_OVER_ANNOTATED':
      1}.
- id: GO_REF:0000033
  title: Annotation inferences using phylogenetic trees
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      PANTHER/phylogenetic inference provenance used for conserved GSK3B kinase, localization,
      and pathway annotations. Action counts in this review: {'KEEP_AS_NON_CORE':
      7, 'ACCEPT': 11}.
- id: GO_REF:0000044
  title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular 
    Location vocabulary mapping, accompanied by conservative changes to GO terms
    applied by UniProt
  findings: []
- id: GO_REF:0000052
  title: Gene Ontology annotation based on curation of immunofluorescence data
  findings: []
- id: GO_REF:0000107
  title: Automatic transfer of experimentally verified manual GO annotation data
    to orthologs using Ensembl Compara
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      High-use Compara orthology-transfer provenance for many non-core and some accepted
      GSK3B annotations; useful for interpreting propagated annotation strength. Action
      counts in this review: {'ACCEPT': 6, 'KEEP_AS_NON_CORE': 35}.
- id: GO_REF:0000108
  title: Automatic assignment of GO terms using logical inference, based on on 
    inter-ontology links
  findings: []
- id: GO_REF:0000117
  title: Electronic Gene Ontology annotations created by ARBA machine learning 
    models
  findings: []
  reference_review:
    relevance: LOW
    correctness: VERIFIED
    review_notes: >-
      ARBA electronic annotation provenance; relevant mainly for non-core or over-annotated
      propagated calls and interpreted cautiously. Action counts in this review: {'MARK_AS_OVER_ANNOTATED':
      1, 'KEEP_AS_NON_CORE': 3, 'ACCEPT': 2}.
- id: GO_REF:0000120
  title: Combined Automated Annotation using Multiple IEA Methods
  findings: []
  reference_review:
    relevance: LOW
    correctness: VERIFIED
    review_notes: >-
      Combined automated annotation provenance; relevant mainly as electronic support
      and interpreted cautiously in the review. Action counts in this review: {'MODIFY':
      1, 'ACCEPT': 6}.
- id: PMID:10428961
  title: Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in 
    Wnt-mediated regulation of LEF-1.
  findings: []
- id: PMID:10481074
  title: A GSK3-binding peptide from FRAT1 selectively inhibits the 
    GSK3-catalysed phosphorylation of axin and beta-catenin.
  findings: []
- id: PMID:11004522
  title: Cloning and characterization of a novel human ninein protein that 
    interacts with the glycogen synthase kinase 3beta.
  findings: []
- id: PMID:11035810
  title: Phosphorylation and inactivation of glycogen synthase kinase 3 by 
    protein kinase A.
  findings: []
- id: PMID:11104755
  title: Substitution of a glycogen synthase kinase-3beta phosphorylation site 
    in presenilin 1 separates presenilin function from beta-catenin signaling.
  findings: []
- id: PMID:11738041
  title: The structure of phosphorylated GSK-3beta complexed with a peptide, 
    FRATtide, that inhibits beta-catenin phosphorylation.
  findings: []
- id: PMID:11955436
  title: Control of beta-catenin phosphorylation/degradation by a dual-kinase 
    mechanism.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary beta-catenin phosphorylation/degradation paper 
      supporting GSK-3 action downstream of CKI priming in Wnt/beta-catenin 
      regulation.
- id: PMID:12223487
  title: The regulation of glycogen synthase kinase-3 nuclear export by 
    Frat/GBP.
  findings: []
- id: PMID:12421363
  title: Axin negatively affects tau phosphorylation by glycogen synthase kinase
    3beta.
  findings: []
- id: PMID:12434148
  title: Crystal structure of an activated Akt/protein kinase B ternary complex 
    with GSK3-peptide and AMP-PNP.
  findings: []
- id: PMID:12927815
  title: 'Molecular characterization of human ninein protein: two distinct subdomains
    required for centrosomal targeting and regulating signals in cell cycle.'
  findings: []
- id: PMID:14690523
  title: Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 
    3beta (GSK3beta) plays a critical role in regulating tau's ability to bind 
    and stabilize microtubules.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary tau-phosphorylation study supporting GSK3B tau-protein
      kinase activity and reduced tau microtubule binding/stabilization.
- id: PMID:14744935
  title: Endoplasmic reticulum stress induces p53 cytoplasmic localization and 
    prevents p53-dependent apoptosis by a pathway involving glycogen synthase 
    kinase-3beta.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      GOA original evidence for ER-stress/p53/apoptosis-related GSK3B annotations;
      supports a real but non-core stress-response branch. Action counts in this review:
      {'MARK_AS_OVER_ANNOTATED': 1, 'KEEP_AS_NON_CORE': 4, 'ACCEPT': 4}.
- id: PMID:14749367
  title: Regulation of apoptosis by the Ft1 protein, a new modulator of protein 
    kinase B/Akt.
  findings: []
- id: PMID:15147888
  title: A novel ninein-interaction protein, CGI-99, blocks ninein 
    phosphorylation by GSK3beta and is highly expressed in brain tumors.
  findings: []
- id: PMID:15448698
  title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in 
    control of epithelial-mesenchymal transition.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Primary Snail/EMT paper supporting a non-core EMT and 
      protein-localization/degradation branch.
- id: PMID:15465828
  title: Phosphorylation of serine 468 by GSK-3beta negatively regulates basal 
    p65 NF-kappaB activity.
  findings: []
- id: PMID:15752768
  title: Characterization of two non-testis-specific CABYR variants that bind to
    GSK3beta with a proline-rich extensin-like domain.
  findings: []
- id: PMID:16188939
  title: The adenomatous polyposis coli protein (APC) exists in two distinct 
    soluble complexes with different functions.
  findings: []
- id: PMID:16282323
  title: Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates 
    BimEL apoptotic function.
  findings: []
- id: PMID:16315267
  title: GSK3B polymorphisms alter transcription and splicing in Parkinson's 
    disease.
  findings: []
- id: PMID:16365045
  title: The low density lipoprotein receptor-related protein 6 interacts with 
    glycogen synthase kinase 3 and attenuates activity.
  findings: []
- id: PMID:16705181
  title: Multisite protein kinase A and glycogen synthase kinase 3beta 
    phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.
  findings: []
- id: PMID:16890161
  title: Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and 
    accumulation of beta-catenin.
  findings: []
- id: PMID:16981698
  title: GSKIP is homologous to the Axin GSK3beta interaction domain and 
    functions as a negative regulator of GSK3beta.
  findings: []
- id: PMID:17050006
  title: Glycogen synthase kinase-3beta binds to E2F1 and regulates its 
    transcriptional activity.
  findings: []
- id: PMID:17078951
  title: PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in 
    site- and kinase-specific manners.
  findings: []
- id: PMID:17139249
  title: GSK-3beta-regulated interaction of BICD with dynein is involved in 
    microtubule anchorage at centrosome.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      GOA original evidence for BICD/dynein, microtubule anchorage, and centrosome-related
      GSK3B annotations; supports non-core cytoskeletal context. Action counts in
      this review: {'MARK_AS_OVER_ANNOTATED': 1, 'KEEP_AS_NON_CORE': 4, 'ACCEPT':
      1}.
- id: PMID:17317006
  title: 14-3-3zeta facilitates GSK3beta-catalyzed tau phosphorylation in 
    HEK-293 cells by a mechanism that requires phosphorylation of GSK3beta on 
    Ser9.
  findings: []
- id: PMID:17318191
  title: Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its
    tyrosine phosphorylation.
  findings: []
- id: PMID:17510365
  title: Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin 
    signaling.
  findings: []
- id: PMID:17601533
  title: Two functionally distinct Axin-like proteins regulate canonical Wnt 
    signaling in C. elegans.
  findings: []
- id: PMID:17681942
  title: Regulation of human cytidine triphosphate synthetase 1 by glycogen 
    synthase kinase 3.
  findings: []
- id: PMID:17989287
  title: Activation of glycogen synthase kinase-3 inhibits long-term 
    potentiation with synapse-associated impairments.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      GOA original evidence for synaptic/LTP-related GSK3B annotations; supports non-core
      neuronal signaling consequences. Action counts in this review: {'KEEP_AS_NON_CORE':
      6}.
- id: PMID:18045539
  title: 'Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1
    signal.'
  findings: []
- id: PMID:18156211
  title: 'Regulation of endothelial cell cytoskeletal reorganization by a secreted
    frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role
    in neovessel formation.'
  findings: []
- id: PMID:18268107
  title: Microtubule stabilization specifies initial neuronal polarization.
  findings: []
- id: PMID:18348280
  title: Importance of autophosphorylation at Ser186 in the A-loop of salt 
    inducible kinase 1 for its sustained kinase activity.
  findings: []
- id: PMID:18505846
  title: p53 stabilization in response to DNA damage requires Akt/PKB and 
    DNA-PK.
  findings: []
- id: PMID:18593713
  title: Smad7 stabilizes beta-catenin binding to E-cadherin complex and 
    promotes cell-cell adhesion.
  findings: []
- id: PMID:18687691
  title: Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone 
    in prostate cancer cells.
  findings: []
- id: PMID:18787224
  title: Constitutive activation of the Wnt canonical pathway in mantle cell 
    lymphoma.
  findings: []
- id: PMID:18846110
  title: Identification of an antiapoptotic protein complex at death receptors.
  findings: []
- id: PMID:19038973
  title: Identification of WNT/beta-CATENIN signaling pathway components in 
    human cumulus cells.
  findings: []
- id: PMID:19131971
  title: The Axin1 scaffold protein promotes formation of a degradation complex 
    for c-Myc.
  findings: []
- id: PMID:19202075
  title: Beta-arrestin links endothelin A receptor to beta-catenin signaling to 
    induce ovarian cancer cell invasion and metastasis.
  findings: []
- id: PMID:19249679
  title: Oncogenic function of ATDC in pancreatic cancer through Wnt pathway 
    activation and beta-catenin stabilization.
  findings: []
- id: PMID:19303846
  title: Disrupted in schizophrenia 1 regulates neuronal progenitor 
    proliferation via modulation of GSK3beta/beta-catenin signaling.
  findings: []
- id: PMID:19364825
  title: Identification of domains responsible for ubiquitin-dependent 
    degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 
    kinases.
  findings: []
- id: PMID:19366350
  title: 'Glycogen synthase kinase 3: more than a namesake.'
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Review supporting broad GSK3 pathway context in metabolism, 
      Wnt, tau, diabetes, and Alzheimer disease.
- id: PMID:19411070
  title: Stabilization of snail by NF-kappaB is required for 
    inflammation-induced cell migration and invasion.
  findings: []
- id: PMID:19581563
  title: Association of GSK3beta polymorphisms with brain structural changes in 
    major depressive disorder.
  findings: []
- id: PMID:19706605
  title: GSK-3 phosphorylates delta-catenin and negatively regulates its 
    stability via ubiquitination/proteosome-mediated proteolysis.
  findings: []
- id: PMID:19759537
  title: Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
  findings: []
- id: PMID:19830702
  title: GSKIP, an inhibitor of GSK3beta, mediates the N-cadherin/beta-catenin 
    pool in the differentiation of SH-SY5Y cells.
  findings: []
- id: PMID:20007971
  title: Glycogen synthase kinase 3beta interaction protein functions as an 
    A-kinase anchoring protein.
  findings: []
- id: PMID:20080667
  title: Role of DAB2IP in modulating epithelial-to-mesenchymal transition and 
    prostate cancer metastasis.
  findings: []
- id: PMID:20368287
  title: Interactome mapping of the phosphatidylinositol 3-kinase-mammalian 
    target of rapamycin pathway identifies deformed epidermal autoregulatory 
    factor-1 as a new glycogen synthase kinase-3 interactor.
  findings: []
- id: PMID:20389281
  title: The SNAG domain of Snail1 functions as a molecular hook for recruiting 
    lysine-specific demethylase 1.
  findings: []
- id: PMID:20856200
  title: Vimentin is a novel AKT1 target mediating motility and invasion.
  findings: []
- id: PMID:20864106
  title: PTEN differentially regulates expressions of ICAM-1 and VCAM-1 through 
    PI3K/Akt/GSK-3β/GATA-6 signaling pathways in TNF-α-activated human 
    endothelial cells.
  findings: []
- id: PMID:20937854
  title: ErbB2 receptor controls microtubule capture by recruiting ACF7 to the 
    plasma membrane of migrating cells.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      GOA original evidence for localization, phosphorylation, and microtubule-process
      annotations in an ErbB2/ACF7 migration context; supports a cytoskeletal branch.
      Action counts in this review: {'ACCEPT': 4}.
- id: PMID:21029237
  title: 'Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer''s
    disease.'
  findings: []
- id: PMID:21118991
  title: The EDD E3 ubiquitin ligase ubiquitinates and up-regulates 
    beta-catenin.
  findings: []
- id: PMID:21217772
  title: Glycogen synthase kinase-3β is a crucial mediator of signal-induced 
    RelB degradation.
  findings: []
- id: PMID:21242974
  title: Methylation by protein arginine methyltransferase 1 increases stability
    of Axin, a negative regulator of Wnt signaling.
  findings: []
- id: PMID:21343617
  title: ER stress inhibits mTORC2 and Akt signaling through GSK-3β-mediated 
    phosphorylation of rictor.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Primary ER-stress/mTORC2 paper supporting non-core RICTOR 
      phosphorylation and TORC2/Akt signaling regulation.
- id: PMID:21399614
  title: Novel asymmetrically localizing components of human centrosomes 
    identified by complementary proteomics methods.
  findings: []
- id: PMID:21711983
  title: A role for Akt and glycogen synthase kinase-3 as integrators of 
    dopamine and serotonin neurotransmission in mental health.
  findings: []
- id: PMID:21743491
  title: Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis 
    through activation of a novel EGR1/β-catenin signaling axis.
  findings: []
- id: PMID:21900206
  title: A directed protein interaction network for investigating intracellular 
    signal transduction.
  findings: []
- id: PMID:21985244
  title: Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β.
  findings: []
- id: PMID:21988832
  title: Toward an understanding of the protein interaction network of the human
    liver.
  findings: []
- id: PMID:22470507
  title: Oncogenic function of DACT1 in colon cancer through the regulation of 
    β-catenin.
  findings: []
- id: PMID:22539723
  title: GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to 
    autophagy.
  findings: []
- id: PMID:22660580
  title: F-box protein FBXL19-mediated ubiquitination and degradation of the 
    receptor for IL-33 limits pulmonary inflammation.
  findings: []
- id: PMID:22682247
  title: Wnt signaling through inhibition of β-catenin degradation in an intact 
    Axin1 complex.
  findings: []
- id: PMID:22699938
  title: Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to 
    enhance Wnt signalling.
  findings: []
- id: PMID:22773187
  title: Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during
    anteroposterior neural patterning.
  findings: []
- id: PMID:22988876
  title: The importance of Wnt signalling for neurodegeneration in Parkinson's 
    disease.
  findings: []
- id: PMID:23010592
  title: NOK/STYK1 interacts with GSK-3β and mediates Ser9 phosphorylation 
    through activated Akt.
  findings: []
- id: PMID:23184662
  title: Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin 
    A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.
  findings: []
- id: PMID:23455922
  title: Interlaboratory reproducibility of large-scale human protein-complex 
    analysis by standardized AP-MS.
  findings: []
- id: PMID:23602568
  title: The protein interaction landscape of the human CMGC kinase group.
  findings: []
- id: PMID:24023731
  title: miR-346 regulates osteogenic differentiation of human bone 
    marrow-derived mesenchymal stem cells by targeting the Wnt/β-catenin 
    pathway.
  findings: []
- id: PMID:24115276
  title: The regulation and deregulation of Wnt signaling by PARK genes in 
    health and disease.
  findings: []
- id: PMID:24165324
  title: Leucine-rich repeat kinase 2 regulates tau phosphorylation through 
    direct activation of glycogen synthase kinase-3β.
  findings: []
- id: PMID:24391509
  title: NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein 
    that inhibits GSK3β resulting in the stabilization of MYCN in human 
    neuroblastomas.
  findings: []
- id: PMID:24431302
  title: Wnt signaling in midbrain dopaminergic neuron development and 
    regenerative medicine for Parkinson's disease.
  findings: []
- id: PMID:24879152
  title: Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
  findings: []
- id: PMID:24976009
  title: YAP/TAZ incorporation in the β-catenin destruction complex orchestrates
    the Wnt response.
  findings: []
- id: PMID:25118933
  title: The protease Omi regulates mitochondrial biogenesis through the 
    GSK3β/PGC-1α pathway.
  findings: []
- id: PMID:25169422
  title: HN1 negatively influences the β-catenin/E-cadherin interaction, and 
    contributes to migration in prostate cells.
  findings: []
- id: PMID:25241761
  title: Using an in situ proximity ligation assay to systematically profile 
    endogenous protein-protein interactions in a pathway network.
  findings: []
- id: PMID:25733715
  title: GSK3- and PRMT-1-dependent modifications of desmoplakin control 
    desmoplakin-cytoskeleton dynamics.
  findings: []
- id: PMID:25827072
  title: FBXO11 promotes ubiquitination of the Snail family of transcription 
    factors in cancer progression and epidermal development.
  findings: []
- id: PMID:25897075
  title: Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, 
    FBXW7-mediated Ubiquitination and Proteasomal Degradation.
  findings: []
- id: PMID:25920809
  title: GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis 
    signaling in the regulation of mitochondrial elongation.
  findings: []
- id: PMID:26049140
  title: A WNT1-regulated developmental gene cascade prevents dopaminergic 
    neurodegeneration in adult En1(+/-) mice.
  findings: []
- id: PMID:26315788
  title: miRNA-99b-3p functions as a potential tumor suppressor by targeting 
    glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells.
  findings: []
- id: PMID:26496610
  title: A human interactome in three quantitative dimensions organized by 
    stoichiometries and abundances.
  findings: []
- id: PMID:26618561
  title: Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates 
    Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?
  findings: []
- id: PMID:27050373
  title: 'The role of glycogen synthase kinase-3β (GSK-3β) in endometrial carcinoma:
    A carcinogenesis, progression, prognosis, and target therapy marker.'
  findings: []
- id: PMID:27484798
  title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β 
    Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions 
    with Both Protein Kinase A (PKA) and GSK3β.
  findings: []
- id: PMID:27494834
  title: GSK3β inactivation promotes the oncogenic functions of EZH2 and 
    enhances methylation of H3K27 in human breast cancers.
  findings: []
- id: PMID:27601169
  title: Vitamin D receptor is a novel transcriptional regulator for Axin1.
  findings: []
- id: PMID:27846906
  title: Upregulation of miR-501-5p activates the wnt/β-catenin signaling 
    pathway and enhances stem cell-like phenotype in gastric cancer.
  findings: []
- id: PMID:28122350
  title: Transcriptional suppression of microRNA-27a contributes to laryngeal 
    cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
  findings: []
- id: PMID:28386764
  title: Roles of tau protein in health and disease.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: >-
      GOA original evidence for tau-health/disease context; supports tau-relevant
      GSK3B annotations but is treated as contextual rather than sole primary evidence.
      Action counts in this review: {'ACCEPT': 3}.
- id: PMID:28829046
  title: Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and 
    colorectal tumorigenesis.
  findings: []
- id: PMID:28903391
  title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating
    the stability and activity of BMAL1 and CLOCK.
  findings: []
- id: PMID:28992046
  title: Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene 
    expression and activate lung epithelial cells.
  findings: []
- id: PMID:29059170
  title: SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent
    manner and regulates metastasis.
  findings: []
- id: PMID:29142209
  title: Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and
    neck squamous cell carcinoma.
  findings: []
- id: PMID:29568061
  title: An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of
    protein interactions and subcellular localizations.
  findings: []
- id: PMID:30556160
  title: miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β 
    in Alzheimer's disease.
  findings: []
- id: PMID:31073040
  title: LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
  findings: []
- id: PMID:31640277
  title: GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but 
    Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal 
    Fluid and iPS Cells in Alzheimer Disease.
  findings: []
- id: PMID:32707033
  title: Kinase Interaction Network Expands Functional and Disease Roles of 
    Human Kinases.
  findings: []
- id: PMID:33248025
  title: Phosphoregulation of Phase Separation by the SARS-CoV-2 N Protein 
    Suggests a Biophysical Basis for its Dual Functions.
  findings: []
- id: PMID:33961781
  title: Dual proteome-scale networks reveal cell-specific remodeling of the 
    human interactome.
  findings: []
- id: PMID:34058472
  title: A catenin of the plakophilin-subfamily, Pkp3, responds to canonical-Wnt
    pathway components and signals.
  findings: []
- id: PMID:34232536
  title: Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors 
    potentially affecting pathogenesis.
  findings: []
- id: PMID:35063084
  title: Tau interactome maps synaptic and mitochondrial processes associated 
    with neurodegeneration.
  findings: []
- id: PMID:35271311
  title: 'OpenCell: Endogenous tagging for the cartography of human cellular organization.'
  findings: []
- id: PMID:35512704
  title: Systematic discovery of mutation-directed neo-protein-protein 
    interactions in cancer.
  findings: []
- id: PMID:35606353
  title: GSK3β palmitoylation mediated by ZDHHC4 promotes tumorigenicity of 
    glioblastoma stem cells in temozolomide-resistant glioblastoma through the 
    EZH2-STAT3 axis.
  findings: []
- id: PMID:40274799
  title: TTC36 promotes proliferation and drug resistance in hepatocellular 
    carcinoma cells by inhibiting c-Myc degradation.
  findings: []
- id: PMID:8638126
  title: Binding of GSK3beta to the APC-beta-catenin complex and regulation of 
    complex assembly.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Primary Wnt/APC/beta-catenin paper supporting GSK3B binding to
      the APC-beta-catenin complex and phosphorylation-dependent beta-catenin 
      regulation.
- id: PMID:8725894
  title: Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with 
    neurofibrillary tangles.
  findings: []
- id: PMID:9072970
  title: Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Primary NFAT paper supporting a non-core transcription-factor 
      nuclear-export branch.
- id: PMID:9482734
  title: Axin, a negative regulator of the Wnt signaling pathway, forms a 
    complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent 
    phosphorylation of beta-catenin.
  findings: []
- id: PMID:9601641
  title: Downregulation of beta-catenin by human Axin and its association with 
    the APC tumor suppressor, beta-catenin and GSK3 beta.
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: >-
      GOA original evidence for Axin/APC/beta-catenin association and beta-catenin
      downregulation, supporting core Wnt/destruction-complex GSK3B biology. Action
      counts in this review: {'ACCEPT': 4, 'MARK_AS_OVER_ANNOTATED': 1}.
- id: PMID:9731200
  title: Human dynamin-like protein interacts with the glycogen synthase kinase 
    3beta.
  findings: []
- id: Reactome:R-HSA-1504186
  title: DVL recruits GSK3beta:AXIN1 to the receptor complex
  findings: []
- id: Reactome:R-HSA-195251
  title: Assembly of the destruction complex
  findings: []
- id: Reactome:R-HSA-195275
  title: Phosphorylation of APC component of the destruction complex
  findings: []
- id: Reactome:R-HSA-195280
  title: Dissociation of beta-catenin from Axin and association of beta catenin 
    with phospho-(20 aa) APC in the detruction complex
  findings: []
- id: Reactome:R-HSA-195283
  title: Phosphorylation of phospho- (Ser45, Thr41) beta-catenin  at Ser37 by 
    GSK-3
  findings: []
- id: Reactome:R-HSA-195287
  title: Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3
  findings: []
- id: Reactome:R-HSA-195300
  title: Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3
  findings: []
- id: Reactome:R-HSA-195304
  title: Association of beta-catenin with the destruction complex
  findings: []
- id: Reactome:R-HSA-195318
  title: Phosphorylation of beta-catenin at Ser45 by CK1 alpha
  findings: []
- id: Reactome:R-HSA-201677
  title: Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated 
    GSK3beta
  findings: []
- id: Reactome:R-HSA-201685
  title: Beta-catenin is released from the destruction complex
  findings: []
- id: Reactome:R-HSA-2130279
  title: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin 
    ligase complex
  findings: []
- id: Reactome:R-HSA-2130282
  title: Degradation of ubiquitinated beta catenin by the proteasome
  findings: []
- id: Reactome:R-HSA-2130286
  title: Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
  findings: []
- id: Reactome:R-HSA-2399966
  title: AKT1 E17K mutant phosphorylates GSK3
  findings: []
- id: Reactome:R-HSA-3371435
  title: Constitutive phosphorylation by GSK3
  findings: []
- id: Reactome:R-HSA-3371453
  title: Regulation of HSF1-mediated heat shock response
  findings: []
- id: Reactome:R-HSA-399951
  title: Phosphorylation of CRMPs by GSK3beta
  findings: []
- id: Reactome:R-HSA-4641262
  title: Disassembly of the destruction complex and recruitment of AXIN to the 
    membrane
  findings: []
- id: Reactome:R-HSA-4791278
  title: APC truncation mutants have impaired AXIN binding
  findings: []
- id: Reactome:R-HSA-4827388
  title: CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
  findings: []
- id: Reactome:R-HSA-4839634
  title: CTNNB1 S33 mutants aren't phosphorylated by GSK3beta
  findings: []
- id: Reactome:R-HSA-4839635
  title: CTNNB1 S37 mutants aren't phosphorylated by GSK3beta
  findings: []
- id: Reactome:R-HSA-4839638
  title: CTNNB1 T41 mutants aren't phosphorylated by GSK3beta
  findings: []
- id: Reactome:R-HSA-4839734
  title: AXIN mutants destabilize the destruction complex
  findings: []
- id: Reactome:R-HSA-4839746
  title: Truncated AMER1 mutants destabilize the destruction complex
  findings: []
- id: Reactome:R-HSA-5229343
  title: AXIN is phosphorylated in the destruction complex
  findings: []
- id: Reactome:R-HSA-5323526
  title: FRAT proteins bind GSK3beta
  findings: []
- id: Reactome:R-HSA-5339713
  title: Misspliced GSK3beta mutants stabilize beta-catenin levels
  findings: []
- id: Reactome:R-HSA-5368596
  title: WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6
  findings: []
- id: Reactome:R-HSA-5610732
  title: GSK3 phosphorylates p-GLI3
  findings: []
- id: Reactome:R-HSA-9683610
  title: Maturation of nucleoprotein
  findings: []
- id: Reactome:R-HSA-9683664
  title: GSK3 phosphorylates Nucleoprotein
  findings: []
- id: Reactome:R-HSA-9687724
  title: GSK3B binds GSKi
  findings: []
- id: Reactome:R-HSA-9694631
  title: Maturation of nucleoprotein
  findings: []
- id: Reactome:R-HSA-9729260
  title: GSK3 phosphorylates nucleoprotein
  findings: []
- id: Reactome:R-HSA-9762094
  title: GSK3B phosphorylates p-NFE2L2
  findings: []
- id: Reactome:R-HSA-9824995
  title: GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405
  findings: []
- id: Reactome:R-HSA-9824999
  title: GSK3B phosphorylates p-S73 MITF-M at residue S69
  findings: []
- id: Reactome:R-HSA-9929360
  title: GSK3B phosphorylates CD274
  findings: []
- id: Reactome:R-HSA-9943675
  title: GSK3B phosphorylates CDC25A
  findings: []
- id: Reactome:R-NUL-1458902
  title: frog CK1gamma phosphorylates LRP5/6
  findings: []
- id: Reactome:R-NUL-209146
  title: Murine Axin1 is further phosphorylated by Human GSK3beta
  findings: []
- id: Reactome:R-NUL-9008555
  title: Runx2 binds GSK3B
  findings: []
- id: Reactome:R-NUL-9008636
  title: GSK3B phosphorylates Runx2
  findings: []
- id: file:human/GSK3B/GSK3B-uniprot.txt
  title: UniProt text export for GSK3B (P49841)
  findings: []
  reference_review:
    relevance: HIGH
    correctness: VERIFIED
    review_notes: Local UniProt record directly summarizes GSK3B kinase 
      activity, substrate specificity, catalytic reactions, Wnt/beta-catenin, 
      glycogen/insulin, tau, regulation, and localization evidence.
- id: file:human/GSK3B/GSK3B-notes.md
  title: Manual GSK3B review notes
  findings: []
  reference_review:
    relevance: MEDIUM
    correctness: VERIFIED
    review_notes: Manual notes document the deep-research timeout and summarize 
      cached UniProt, PANTHER, GOA, Reactome, and publication evidence used for 
      this review.
core_functions:
- description: ATP-dependent protein serine/threonine kinase activity with 
    primed-substrate preference, regulated by activating Tyr-216 phosphorylation
    and inhibitory Ser-9 phosphorylation.
  supported_by:
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: Constitutively active protein kinase
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: L-seryl-[protein] + ATP
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: Activated by phosphorylation at Tyr-216
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: inhibited by phosphorylation at Ser-9
  molecular_function:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  directly_involved_in:
  - id: GO:0006468
    label: protein phosphorylation
  - id: GO:0018105
    label: peptidyl-serine phosphorylation
  - id: GO:0046777
    label: protein autophosphorylation
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005737
    label: cytoplasm
  - id: GO:0005634
    label: nucleus
- description: Tau-protein kinase activity relevant to Alzheimer disease, 
    phosphorylating MAPT/tau and reducing tau microtubule binding and 
    stabilization.
  supported_by:
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: L-seryl-[tau protein] + ATP
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: L-threonyl-[tau protein] + ATP
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: Phosphorylates MAPT/TAU on
  - reference_id: PMID:14690523
    supporting_text: tau's ability to bind and stabilize microtubules
  - reference_id: PMID:14690523
    supporting_text: GSK3beta plays a critical role
  molecular_function:
    id: GO:0050321
    label: tau-protein kinase activity
  directly_involved_in:
  - id: GO:0070507
    label: regulation of microtubule cytoskeleton organization
  - id: GO:0032886
    label: regulation of microtubule-based process
  - id: GO:0010975
    label: regulation of neuron projection development
  locations:
  - id: GO:0005829
    label: cytosol
- description: Canonical Wnt/beta-catenin negative regulation through 
    beta-catenin binding, beta-catenin destruction-complex participation, CTNNB1
    phosphorylation, and proteasomal substrate turnover.
  supported_by:
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: phosphorylates the N-terminus of CTNNB1 leading to its 
      degradation
  - reference_id: PMID:8638126
    supporting_text: APC binds to another component of the WINGLESS pathway
  - reference_id: PMID:11955436
    supporting_text: Wnt regulation of beta-catenin degradation
  - reference_id: PMID:11955436
    supporting_text: subsequent GSK-3 phosphorylation
  molecular_function:
    id: GO:0008013
    label: beta-catenin binding
  directly_involved_in:
  - id: GO:0090090
    label: negative regulation of canonical Wnt signaling pathway
  - id: GO:0032436
    label: positive regulation of proteasomal ubiquitin-dependent protein 
      catabolic process
  - id: GO:0043161
    label: proteasome-mediated ubiquitin-dependent protein catabolic process
  locations:
  - id: GO:0005829
    label: cytosol
  in_complex:
    id: GO:0030877
    label: beta-catenin destruction complex
- description: Insulin-linked glycogen-metabolism regulation by phosphorylation 
    and inhibition of glycogen synthase, contributing to negative control of 
    glycogen biosynthesis.
  supported_by:
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: phosphorylating and inactivating glycogen synthase
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: insulin regulation of glycogen synthesis
  - reference_id: file:human/GSK3B/GSK3B-uniprot.txt
    supporting_text: phosphorylating and inhibiting GYS1 activity
  molecular_function:
    id: GO:0004674
    label: protein serine/threonine kinase activity
  directly_involved_in:
  - id: GO:0005977
    label: glycogen metabolic process
  - id: GO:0045719
    label: negative regulation of glycogen biosynthetic process
  - id: GO:2000466
    label: negative regulation of glycogen (starch) synthase activity
  - id: GO:0008286
    label: insulin receptor signaling pathway
  locations:
  - id: GO:0005829
    label: cytosol
  - id: GO:0005737
    label: cytoplasm
proposed_new_terms: []
suggested_questions:
- question: Which GSK3B pathway annotations should be treated as central 
    kinase/substrate biology versus pleiotropic downstream effects of a broadly 
    connected kinase?
- question: For Alzheimer disease, should GSK3B curation emphasize tau 
    phosphorylation and microtubule regulation, Wnt/beta-catenin signaling, 
    insulin/glycogen metabolism, synaptic signaling, or all as separate 
    non-equivalent branches?
- question: Which generic high-throughput protein-interaction annotations can be
    replaced by reproducible endogenous substrate, scaffold, or 
    regulator-specific GO terms?
suggested_experiments:
- hypothesis: Alzheimer-relevant GSK3B effects depend on separable 
    tau-phosphorylation and Wnt/beta-catenin substrate pools rather than global 
    kinase abundance alone.
  description: Use endogenous GSK3B perturbation and phosphosite-specific rescue
    in human iPSC-derived neurons and glia, measuring tau 
    phosphorylation/microtubule binding, beta-catenin degradation, 
    glycogen/insulin signaling, synaptic phenotypes, and cell viability under 
    amyloid or inflammatory stress.
  experiment_type: substrate-resolved kinase perturbation assay
- hypothesis: Primed-substrate docking determines which GSK3B GO pathway outputs
    are direct functions versus secondary pathway consequences.
  description: Perform quantitative phosphoproteomics after acute GSK3B 
    inhibition or analog-sensitive GSK3B mutation, then classify direct 
    phosphosites by priming dependence and map them to tau, CTNNB1, GYS1, 
    RICTOR, SNAI1, NFAT, and other candidate substrate pathways.
  experiment_type: acute kinase-substrate phosphoproteomics

Gene Description

Existing Annotations Review

Core Functions

ATP-dependent protein serine/threonine kinase activity with primed-substrate preference, regulated by activating Tyr-216 phosphorylation and inhibitory Ser-9 phosphorylation.

Tau-protein kinase activity relevant to Alzheimer disease, phosphorylating MAPT/tau and reducing tau microtubule binding and stabilization.

Canonical Wnt/beta-catenin negative regulation through beta-catenin binding, beta-catenin destruction-complex participation, CTNNB1 phosphorylation, and proteasomal substrate turnover.

Insulin-linked glycogen-metabolism regulation by phosphorylation and inhibition of glycogen synthase, contributing to negative control of glycogen biosynthesis.

References

Suggested Questions for Experts

Suggested Experiments

📚 Additional Documentation

Notes

GSK3B notes

2026-06-20 second-pass audit

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