HCST

UniProt ID: Q9UBK5
Organism: Homo sapiens
Review Status: INITIALIZED
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Gene Description

TODO: Add description for HCST

Existing Annotations Review

GO Term Evidence Action Reason
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043548 phosphatidylinositol 3-kinase binding
IBA
GO_REF:0000033 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005102 signaling receptor binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0016020 membrane
IEA
GO_REF:0000120 		PENDING
Summary: TODO: Review this GOA annotation
GO:0043548 phosphatidylinositol 3-kinase binding
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0050776 regulation of immune response
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IEA
GO_REF:0000002 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:32296183
A reference map of the human binary protein interactome. 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32296183
Apr 8. A reference map of the human binary protein interactome.
GO:0005515 protein binding
IPI
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
GO:0005886 plasma membrane
IDA
PMID:15894612
The activating NKG2D receptor assembles in the membrane with... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15894612
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.
GO:0030674 protein-macromolecule adaptor activity
IDA
PMID:16582911
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 in... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16582911
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
GO:0042267 natural killer cell mediated cytotoxicity
IDA
PMID:16582911
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 in... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:16582911
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
GO:0005515 protein binding
IPI
PMID:26221034
Identification and Characterization of CD300H, a New Member ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:26221034
2015 Jul 28. Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.
GO:0005102 signaling receptor binding
IPI
PMID:15294961
A Structural basis for the association of DAP12 with mouse, ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15294961
A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.
GO:0009986 cell surface
IDA
PMID:15294961
A Structural basis for the association of DAP12 with mouse, ... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:15294961
A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.
GO:0005886 plasma membrane
TAS
Reactome:R-HSA-198983 		PENDING
Summary: TODO: Review this GOA annotation
GO:0005515 protein binding
IPI
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP10.
GO:0009986 cell surface
IDA
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP10.
GO:0043548 phosphatidylinositol 3-kinase binding
IDA
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP10.
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
IDA
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP... 		PENDING
Summary: TODO: Review this GOA annotation
Supporting Evidence:
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP10.
GO:0006468 protein phosphorylation
IGI
PMID:10528161
Cutting edge: KAP10, a novel transmembrane adapter protein g... 		REMOVE
Summary: MISANNOTATION: HCST (also called KAP10/DAP10) is NOT a kinase. PMID:10528161 explicitly describes HCST as a "transmembrane adapter protein" that "binds phosphatidylinositol-3 kinase following phosphorylation of a cytoplasmic YINM motif, which results in activation of Akt". This means HCST is PHOSPHORYLATED (it's a substrate) and then recruits PI3K signaling - it does not perform phosphorylation. HCST is an adaptor/scaffold for immune receptor signaling.
Supporting Evidence:
PMID:10528161
Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.

References

GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10426994
An activating immunoreceptor complex formed by NKG2D and DAP10.
PMID:10528161
Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties.
PMID:15294961
A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.
PMID:15894612
The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure.
PMID:16582911
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
PMID:26221034
Identification and Characterization of CD300H, a New Member of the Human CD300 Immunoreceptor Family.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Reactome:R-HSA-198983
NKG2D homodimer interacting with ligands

📄 View Raw YAML

 
id: Q9UBK5
gene_symbol: HCST
product_type: PROTEIN
status: INITIALIZED
taxon:
  id: NCBITaxon:9606
  label: Homo sapiens
description: 'TODO: Add description for HCST'
alternative_products:
  - name: '1'
    id: Q9UBK5-1
  - name: '2'
    id: Q9UBK5-2
    sequence_note: VSP_033022
existing_annotations:
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043548
      label: phosphatidylinositol 3-kinase binding
    evidence_type: IBA
    original_reference_id: GO_REF:0000033
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0016020
      label: membrane
    evidence_type: IEA
    original_reference_id: GO_REF:0000120
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0043548
      label: phosphatidylinositol 3-kinase binding
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0050776
      label: regulation of immune response
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IEA
    original_reference_id: GO_REF:0000002
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32296183
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32296183
          supporting_text: Apr 8. A reference map of the human binary protein 
            interactome.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:32814053
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:32814053
          supporting_text: Interactome Mapping Provides a Network of 
            Neurodegenerative Disease Proteins and Uncovers Widespread Protein 
            Aggregation in Affected Brains.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: IDA
    original_reference_id: PMID:15894612
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15894612
          supporting_text: The activating NKG2D receptor assembles in the 
            membrane with two signaling dimers into a hexameric structure.
  - term:
      id: GO:0030674
      label: protein-macromolecule adaptor activity
    evidence_type: IDA
    original_reference_id: PMID:16582911
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16582911
          supporting_text: NKG2D-mediated signaling requires a DAP10-bound 
            Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human 
            natural killer cells.
  - term:
      id: GO:0042267
      label: natural killer cell mediated cytotoxicity
    evidence_type: IDA
    original_reference_id: PMID:16582911
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:16582911
          supporting_text: NKG2D-mediated signaling requires a DAP10-bound 
            Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human 
            natural killer cells.
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:26221034
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:26221034
          supporting_text: 2015 Jul 28. Identification and Characterization of 
            CD300H, a New Member of the Human CD300 Immunoreceptor Family.
  - term:
      id: GO:0005102
      label: signaling receptor binding
    evidence_type: IPI
    original_reference_id: PMID:15294961
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15294961
          supporting_text: A Structural basis for the association of DAP12 with 
            mouse, but not human, NKG2D.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:15294961
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:15294961
          supporting_text: A Structural basis for the association of DAP12 with 
            mouse, but not human, NKG2D.
  - term:
      id: GO:0005886
      label: plasma membrane
    evidence_type: TAS
    original_reference_id: Reactome:R-HSA-198983
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
  - term:
      id: GO:0005515
      label: protein binding
    evidence_type: IPI
    original_reference_id: PMID:10426994
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10426994
          supporting_text: An activating immunoreceptor complex formed by NKG2D 
            and DAP10.
  - term:
      id: GO:0009986
      label: cell surface
    evidence_type: IDA
    original_reference_id: PMID:10426994
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10426994
          supporting_text: An activating immunoreceptor complex formed by NKG2D 
            and DAP10.
  - term:
      id: GO:0043548
      label: phosphatidylinositol 3-kinase binding
    evidence_type: IDA
    original_reference_id: PMID:10426994
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10426994
          supporting_text: An activating immunoreceptor complex formed by NKG2D 
            and DAP10.
  - term:
      id: GO:0051897
      label: positive regulation of phosphatidylinositol 3-kinase/protein kinase
        B signal transduction
    evidence_type: IDA
    original_reference_id: PMID:10426994
    review:
      summary: 'TODO: Review this GOA annotation'
      action: PENDING
      supported_by:
        - reference_id: PMID:10426994
          supporting_text: An activating immunoreceptor complex formed by NKG2D 
            and DAP10.
  - term:
      id: GO:0006468
      label: protein phosphorylation
    evidence_type: IGI
    original_reference_id: PMID:10528161
    review:
      summary: >-
        MISANNOTATION: HCST (also called KAP10/DAP10) is NOT a kinase. PMID:10528161
        explicitly describes HCST as a "transmembrane adapter protein" that "binds
        phosphatidylinositol-3 kinase following phosphorylation of a cytoplasmic YINM
        motif, which results in activation of Akt". This means HCST is PHOSPHORYLATED
        (it's a substrate) and then recruits PI3K signaling - it does not perform
        phosphorylation. HCST is an adaptor/scaffold for immune receptor signaling.
      action: REMOVE
      supported_by:
        - reference_id: PMID:10528161
          supporting_text: 'Cutting edge: KAP10, a novel transmembrane adapter protein
            genetically linked to DAP12 but with unique signaling properties.'
references:
  - id: GO_REF:0000002
    title: Gene Ontology annotation through association of InterPro records with
      GO terms
    findings: []
  - id: GO_REF:0000033
    title: Annotation inferences using phylogenetic trees
    findings: []
  - id: GO_REF:0000120
    title: Combined Automated Annotation using Multiple IEA Methods
    findings: []
  - id: PMID:10426994
    title: An activating immunoreceptor complex formed by NKG2D and DAP10.
    findings: []
  - id: PMID:10528161
    title: 'Cutting edge: KAP10, a novel transmembrane adapter protein genetically
      linked to DAP12 but with unique signaling properties.'
    findings: []
  - id: PMID:15294961
    title: A Structural basis for the association of DAP12 with mouse, but not 
      human, NKG2D.
    findings: []
  - id: PMID:15894612
    title: The activating NKG2D receptor assembles in the membrane with two 
      signaling dimers into a hexameric structure.
    findings: []
  - id: PMID:16582911
    title: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 
      intermediate and phosphatidylinositol-3-kinase in human natural killer 
      cells.
    findings: []
  - id: PMID:26221034
    title: Identification and Characterization of CD300H, a New Member of the 
      Human CD300 Immunoreceptor Family.
    findings: []
  - id: PMID:32296183
    title: A reference map of the human binary protein interactome.
    findings: []
  - id: PMID:32814053
    title: Interactome Mapping Provides a Network of Neurodegenerative Disease 
      Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
    findings: []
  - id: Reactome:R-HSA-198983
    title: NKG2D homodimer interacting with ligands
    findings: []