HNRNPK encodes heterogeneous nuclear ribonucleoprotein K, a multifunctional poly(C)-binding protein built from three KH domains and a K-interactive (KI) docking region. It binds cytidine-rich single-stranded RNA and DNA and participates in pre-mRNA packaging and splicing, mRNA stability and translational control, and transcriptional regulation, including the p53/TP53 DNA-damage response, LDL-receptor gene transactivation, and circRNA-nucleated repressive complexes. Through its KI region it also serves as a signaling docking platform. It is predominantly nuclear/nucleoplasmic and chromatin-associated but shuttles to the cytoplasm, where it localizes to stress granules and ribonucleoprotein complexes.
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000398 mRNA splicing, via spliceosome | IC PMID:11991638 Purification and characterization of native spliceosomes sui... | KEEP AS NON CORE | Summary: Participation in mRNA splicing via the spliceosome. Reason: HNRNPK is present in the spliceosome C complex and modulates splicing; a genuine but non-core process relative to its poly(C)-binding/regulatory roles. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Identified in the spliceosome C complex |
| GO:0000785 chromatin | IDA PMID:20371611 Identification of heterogeneous nuclear ribonucleoprotein K ... | ACCEPT | Summary: HNRNPK associates with chromatin during transcriptional regulation. Reason: Shown by IDA; HNRNPK acts on chromatin as part of transcription-regulatory complexes. Supporting Evidence: PMID:33174841 circZNF827 nucleates a transcription inhibitory complex |
| GO:0000785 chromatin | IDA PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | ACCEPT | Summary: HNRNPK associates with chromatin during transcriptional regulation. Reason: Shown by IDA; HNRNPK acts on chromatin as part of transcription-regulatory complexes. Supporting Evidence: PMID:33174841 circZNF827 nucleates a transcription inhibitory complex |
| GO:0002102 podosome | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: Podosome localization (UniProt subcellular-location mapping). Reason: A curated cytoplasmic location for HNRNPK; peripheral to its core nuclear RNA/DNA functions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Likely to play a role in the nuclear |
| GO:0003676 nucleic acid binding | IEA GO_REF:0000002 | MODIFY | Summary: Nucleic acid binding, from the KH-domain InterPro mapping. Reason: Correct but general; HNRNPK's KH domains bind RNA (and poly(C) ssDNA). RNA binding is the specific, experimentally supported activity already asserted. Proposed replacements: RNA binding Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0003723 RNA binding | HDA PMID:22658674 Insights into RNA biology from an atlas of mammalian mRNA-bi... | ACCEPT | Summary: HNRNPK binds poly(C) RNA tenaciously; a core activity. Reason: Multiple high-throughput RNA-interactome and classic studies establish HNRNPK as a major pre-mRNA/poly(C) RNA-binding protein. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Binds tenaciously |
| GO:0003723 RNA binding | HDA PMID:22681889 The mRNA-bound proteome and its global occupancy profile on ... | ACCEPT | Summary: HNRNPK binds poly(C) RNA tenaciously; a core activity. Reason: Multiple high-throughput RNA-interactome and classic studies establish HNRNPK as a major pre-mRNA/poly(C) RNA-binding protein. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Binds tenaciously |
| GO:0003723 RNA binding | IEA GO_REF:0000002 | ACCEPT | Summary: HNRNPK binds poly(C) RNA tenaciously; a core activity. Reason: Multiple high-throughput RNA-interactome and classic studies establish HNRNPK as a major pre-mRNA/poly(C) RNA-binding protein. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Binds tenaciously |
| GO:0003723 RNA binding | TAS PMID:8107114 Identification, molecular cloning, expression and chromosome... | ACCEPT | Summary: HNRNPK binds poly(C) RNA tenaciously; a core activity. Reason: Multiple high-throughput RNA-interactome and classic studies establish HNRNPK as a major pre-mRNA/poly(C) RNA-binding protein. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Binds tenaciously |
| GO:0003729 mRNA binding | IBA GO_REF:0000033 | ACCEPT | Summary: HNRNPK binds poly(C)-rich pre-mRNAs/mRNAs. Reason: Its defining activity is binding cytidine-rich mRNA sequences; the IBA sits at the right specificity for the poly(C)-binding protein clade. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt pre-mRNAs that contain cytidine-rich |
| GO:0005515 protein binding | IPI PMID:10332027 T-STAR/ETOILE: a novel relative of SAM68 that interacts with... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:10749975 RBMY, a probable human spermatogenesis factor, and other hnR... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:10749975 RBMY, a probable human spermatogenesis factor, and other hnR... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:12183465 An RNA helicase, DDX1, interacting with poly(A) RNA and hete... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:12577067 A proteomics strategy to elucidate functional protein-protei... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:16713569 A protein-protein interaction network for human inherited at... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:17178840 Deciphering the cross talk between hnRNP K and c-Src: the c-... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:18457437 Identification of intracellular proteins associated with the... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:19101556 Physical and functional interactions between hnRNP K and PRM... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:19174163 Proteomic and genomic analysis of PITX2 interacting and regu... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:19249676 MDM2-dependent downregulation of p21 and hnRNP K provides a ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:20085233 Identification of DeltaNp63alpha protein interactions by mas... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:20936779 A human MAP kinase interactome. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21044950 Genome-wide YFP fluorescence complementation screen identifi... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21516116 Next-generation sequencing to generate interactome datasets. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21821029 Aurora-A phosphorylates hnRNPK and disrupts its interaction ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21821029 Aurora-A phosphorylates hnRNPK and disrupts its interaction ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:21988832 Toward an understanding of the protein interaction network o... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cyc... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:23092970 SUMOylation of hnRNP-K is required for p53-mediated cell-cyc... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:23825951 Cellular RNA binding proteins NS1-BP and hnRNP K regulate in... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:24965446 Host factors that interact with the pestivirus N-terminal pr... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:25678563 Peptidylprolyl isomerase A governs TARDBP function and assem... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:26871637 Widespread Expansion of Protein Interaction Capabilities by ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:28298427 Systematic protein-protein interaction mapping for clinicall... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:30021884 Histone Interaction Landscapes Visualized by Crosslinking Ma... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:31413325 HENA, heterogeneous network-based data set for Alzheimer's d... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:31980649 Extensive rewiring of the EGFR network in colorectal cancer ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:35271311 OpenCell: Endogenous tagging for the cartography of human ce... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005515 protein binding | IPI PMID:9651361 Hepatitis C virus core protein interacts with heterogeneous ... | REMOVE | Summary: Generic protein binding from a very large set of pairwise and screen interactions. Reason: Bare protein binding is uninformative and removed under the protein-binding policy. HNRNPK's informative binding is captured by identical protein binding (self-association) and protein domain specific binding (KI/SH3 docking); removal does not dispute the interactions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: HNRNPK is predominantly nuclear. Reason: Classic and IDA evidence place HNRNPK in the nucleus where it performs its core functions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005634 nucleus | IDA PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | ACCEPT | Summary: HNRNPK is predominantly nuclear. Reason: Classic and IDA evidence place HNRNPK in the nucleus where it performs its core functions. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | IDA GO_REF:0000052 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | IEA GO_REF:0000044 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-4570499 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-72103 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9624033 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9698926 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770119 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770129 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770131 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770132 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770141 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770142 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770145 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770236 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9770847 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9794542 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9921250 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9921507 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970141 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970179 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970189 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970190 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970191 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970193 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970282 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970294 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970318 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970320 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970428 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970429 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005654 nucleoplasm | TAS Reactome:R-HSA-9970431 | ACCEPT | Summary: HNRNPK localizes to the nucleoplasm. Reason: The nucleoplasm is its principal functional compartment (transcription/pre-mRNA metabolism). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0005737 cytoplasm | EXP PMID:1729596 Characterization and primary structure of the poly(C)-bindin... | ACCEPT | Summary: HNRNPK shuttles to and functions in the cytoplasm. Reason: A cytoplasmic pool mediates mRNA stability/translation and signaling; experimentally established. Supporting Evidence: PMID:20371611 in the nucleus, cytoplasm, and mitochondria |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: HNRNPK shuttles to and functions in the cytoplasm. Reason: A cytoplasmic pool mediates mRNA stability/translation and signaling; experimentally established. Supporting Evidence: PMID:20371611 in the nucleus, cytoplasm, and mitochondria |
| GO:0005737 cytoplasm | IDA PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | ACCEPT | Summary: HNRNPK shuttles to and functions in the cytoplasm. Reason: A cytoplasmic pool mediates mRNA stability/translation and signaling; experimentally established. Supporting Evidence: PMID:20371611 in the nucleus, cytoplasm, and mitochondria |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: HNRNPK shuttles to and functions in the cytoplasm. Reason: A cytoplasmic pool mediates mRNA stability/translation and signaling; experimentally established. Supporting Evidence: PMID:20371611 in the nucleus, cytoplasm, and mitochondria |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | MARK AS OVER ANNOTATED | Summary: Focal adhesion, from a high-throughput proteomic dataset. Reason: HDA co-enrichment; inconsistent with the dedicated localization of a nuclear RNA-binding protein and not a core function. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Likely to play a role in the nuclear |
| GO:0006355 regulation of DNA-templated transcription | IEA GO_REF:0000117 | TOO GENERAL | Summary: Regulation of DNA-templated transcription (general). Reason: The specific term regulation of transcription by RNA polymerase II is asserted; the general DNA-templated term is entailed by it. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt transcription activation and repression |
| GO:0006357 regulation of transcription by RNA polymerase II | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: HNRNPK regulates RNA polymerase II transcription (e.g. p53 targets). Reason: HNRNPK acts as a transcriptional co-activator/repressor in the p53 response and other programs; a genuine regulatory role, non-core relative to its RNA-binding function. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt p53/TP53 response to DNA damage |
| GO:0006396 RNA processing | TAS PMID:8107114 Identification, molecular cloning, expression and chromosome... | TOO GENERAL | Summary: RNA processing (general). Reason: The specific process mRNA splicing via spliceosome is asserted; the general RNA processing term is entailed by it. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt nuclear metabolism |
| GO:0007165 signal transduction | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | KEEP AS NON CORE | Summary: Signal transduction (HNRNPK as a docking platform). Reason: HNRNPK integrates signaling via its KI docking region; a broad, non-core process term. Supporting Evidence: PMID:20371611 in the nucleus, cytoplasm, and mitochondria |
| GO:0010494 cytoplasmic stress granule | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Cytoplasmic stress-granule localization. Reason: Consistent with HNRNPK's cytoplasmic RNP role under stress; a non-core condition- specific location. Supporting Evidence: PMID:20371611 in the nucleus, cytoplasm, and mitochondria |
| GO:0010629 negative regulation of gene expression | IEA GO_REF:0000117 | KEEP AS NON CORE | Summary: Negative regulation of gene expression. Reason: Consistent with HNRNPK's repressive transcriptional/post-transcriptional roles; a general non-core process. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt transcription activation and repression |
| GO:0016020 membrane | HDA PMID:19946888 Defining the membrane proteome of NK cells. | MARK AS OVER ANNOTATED | Summary: Membrane, from a high-throughput membrane-proteome dataset. Reason: HDA co-enrichment; HNRNPK is not an integral membrane protein, and this is not a core location. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Likely to play a role in the nuclear |
| GO:0019904 protein domain specific binding | IPI PMID:10749975 RBMY, a probable human spermatogenesis factor, and other hnR... | UNDECIDED | Summary: The KI region of HNRNPK binds specific protein domains (e.g. SH3 domains). Reason: This IPI rests on PMID:10749975, whose cached entry is abstract-only and foregrounds RBMY/hnRNP G-Tra2beta interactions; the HNRNPK-specific domain-specific binding event cannot be verified from the abstract, so the call is deferred to the curator who read the full text. Domain-specific docking via the KI region is biologically plausible for HNRNPK. |
| GO:0031048 regulatory ncRNA-mediated heterochromatin formation | IMP PMID:25843628 Systematic discovery of Xist RNA binding proteins. | KEEP AS NON CORE | Summary: Regulatory ncRNA-mediated heterochromatin formation. Reason: HNRNPK is an Xist-interacting protein contributing to X-inactivation heterochromatin; a specific, non-core process. Supporting Evidence: PMID:25843628 Systematic discovery of Xist RNA binding proteins |
| GO:0042802 identical protein binding | IPI P61978-1 PMID:16004877 X-ray crystallographic and NMR studies of the third KH domai... | ACCEPT | Summary: HNRNPK self-associates (identical protein binding). Reason: Multiple interaction datasets report HNRNPK-HNRNPK (P61978) self-association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0042802 identical protein binding | IPI PMID:16189514 Towards a proteome-scale map of the human protein-protein in... | ACCEPT | Summary: HNRNPK self-associates (identical protein binding). Reason: Multiple interaction datasets report HNRNPK-HNRNPK (P61978) self-association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0042802 identical protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | ACCEPT | Summary: HNRNPK self-associates (identical protein binding). Reason: Multiple interaction datasets report HNRNPK-HNRNPK (P61978) self-association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0042802 identical protein binding | IPI PMID:25416956 A proteome-scale map of the human interactome network. | ACCEPT | Summary: HNRNPK self-associates (identical protein binding). Reason: Multiple interaction datasets report HNRNPK-HNRNPK (P61978) self-association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0042802 identical protein binding | IPI PMID:29892012 An interactome perturbation framework prioritizes damaging m... | ACCEPT | Summary: HNRNPK self-associates (identical protein binding). Reason: Multiple interaction datasets report HNRNPK-HNRNPK (P61978) self-association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0042802 identical protein binding | IPI P61978-1 PMID:32499643 RIC-seq for global in situ profiling of RNA-RNA spatial inte... | ACCEPT | Summary: HNRNPK self-associates (identical protein binding). Reason: Multiple interaction datasets report HNRNPK-HNRNPK (P61978) self-association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
| GO:0042981 regulation of apoptotic process | IEA GO_REF:0000117 | TOO GENERAL | Summary: Regulation of apoptotic process (general). Reason: The specific term negative regulation of apoptotic process is asserted (IMP); the general regulation term is entailed by it. Supporting Evidence: PMID:20548952 induces apoptosis |
| GO:0043066 negative regulation of apoptotic process | IMP PMID:20548952 Inactivation of hnRNP K by expanded intronic AUUCU repeat in... | KEEP AS NON CORE | Summary: HNRNPK is anti-apoptotic; its inactivation induces apoptosis. Reason: Loss of HNRNPK function induces apoptosis (SCA10), indicating a normal anti-apoptotic role; a specific downstream process. Supporting Evidence: PMID:20548952 Inactivation of hnRNP K by expanded intronic AUUCU repeat induces apoptosis |
| GO:0045296 cadherin binding | HDA PMID:25468996 E-cadherin interactome complexity and robustness resolved by... | MARK AS OVER ANNOTATED | Summary: Cadherin binding, from a high-throughput proximity/proteomic dataset. Reason: HNRNPK is a nuclear/cytoplasmic RNA-binding protein; the HDA cadherin-binding call reflects proteomic co-enrichment rather than a dedicated adhesion-protein function. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Likely to play a role in the nuclear |
| GO:0045892 negative regulation of DNA-templated transcription | IMP PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | KEEP AS NON CORE | Summary: HNRNPK can repress DNA-templated transcription (circZNF827 complex). Reason: HNRNPK participates in a chromatin-nucleated transcription-inhibitory complex; supported by IMP but a non-core specific process. Supporting Evidence: PMID:33174841 circZNF827 nucleates a transcription inhibitory complex |
| GO:0048024 regulation of mRNA splicing, via spliceosome | IBA GO_REF:0000033 | KEEP AS NON CORE | Summary: Regulation of mRNA splicing via spliceosome. Reason: HNRNPK modulates alternative splicing of target transcripts; a non-core process consistent with its spliceosome association. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Identified in the spliceosome C complex |
| GO:0060816 random inactivation of X chromosome | IDA PMID:25843628 Systematic discovery of Xist RNA binding proteins. | KEEP AS NON CORE | Summary: Random X-chromosome inactivation. Reason: As an Xist RNA-binding protein HNRNPK contributes to X-inactivation; a specific, non-core process. Supporting Evidence: PMID:25843628 Systematic discovery of Xist RNA binding proteins |
| GO:0070062 extracellular exosome | HDA PMID:20458337 MHC class II-associated proteins in B-cell exosomes and pote... | MARK AS OVER ANNOTATED | Summary: Extracellular exosome, from high-throughput exosome proteomics. Reason: HDA proteomic co-purification; a nuclear/cytoplasmic RNA-binding protein's genuine localization is intracellular, so this does not reflect a function at the cell surface or extracellularly. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Likely to play a role in the nuclear |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | MARK AS OVER ANNOTATED | Summary: Extracellular exosome, from high-throughput exosome proteomics. Reason: HDA proteomic co-purification; a nuclear/cytoplasmic RNA-binding protein's genuine localization is intracellular, so this does not reflect a function at the cell surface or extracellularly. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Likely to play a role in the nuclear |
| GO:0071013 catalytic step 2 spliceosome | IDA PMID:11991638 Purification and characterization of native spliceosomes sui... | ACCEPT | Summary: HNRNPK is a component of the catalytic step 2 (C complex) spliceosome. Reason: Identified by IDA in affinity-purified spliceosome C complex. Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt Identified in the spliceosome C complex |
| GO:1905581 positive regulation of low-density lipoprotein particle clearance | IMP PMID:20371611 Identification of heterogeneous nuclear ribonucleoprotein K ... | KEEP AS NON CORE | Summary: Positive regulation of LDL particle clearance via LDLR transactivation. Reason: HNRNPK transactivates the LDL receptor gene, increasing LDL clearance; a specific, non-core downstream process. Supporting Evidence: PMID:20371611 transactivator for human low density lipoprotein receptor gene transcription |
| GO:1990904 ribonucleoprotein complex | IDA PMID:33174841 circZNF827 nucleates a transcription inhibitory complex to b... | ACCEPT | Summary: HNRNPK is a component of ribonucleoprotein complexes. Reason: HNRNPK is a core hnRNP and assembles into RNP complexes (its defining property). Supporting Evidence: file:human/HNRNPK/HNRNPK-uniprot.txt One of the major pre-mRNA-binding proteins |
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Download this section (compressed HTML)Q: Which of HNRNPK's many reported protein interactions are direct KI-region docking events versus RNA-bridged co-associations?
Q: How do post-translational modifications (SUMOylation, phosphorylation) switch HNRNPK between transcriptional co-activation and co-repression of p53 targets?
Experiment: CLIP-seq of endogenous HNRNPK across nuclear and cytoplasmic fractions to define its direct poly(C) RNA targets and partition splicing versus stability/translation roles.
Type: genomics
Experiment: Separation-of-function KH-domain and KI-region mutants to dissect nucleic-acid binding from protein-docking contributions to the p53 response.
Type: molecular biology
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