HSPB1 (HSP27) is a ubiquitously expressed small heat shock protein of the alpha-crystallin domain family. It is most abundant in muscle and is strongly induced by heat and other proteotoxic stresses. It is an ATP-independent molecular chaperone (holdase): dynamic dimer-based oligomers bind exposed hydrophobic surfaces of partially unfolded proteins, prevent their irreversible aggregation and keep them competent for refolding by the HSP70 system or for degradation. MAPKAPK2/3-dependent phosphorylation (Ser15/78/82) dissociates large oligomers into smaller species and modulates client and partner selection. HSPB1 is cytoplasmic, associates with actin and microtubules, and moves to nuclear speckles during heat shock. It contributes to stress resistance and actin cytoskeleton stability, inhibits apoptosis (for example by interfering with DAXX and cytochrome c pathways), and maintains neurofilament phosphorylation and axonal transport. Dominant mutations cause Charcot-Marie-Tooth type 2F and distal hereditary motor neuropathy.
Definition: Binding to an unfolded or misfolded protein to prevent its aggregation without actively catalyzing refolding. The holdase maintains the client protein in a soluble, folding-competent state. This is mechanistically distinct from foldase activity (GO:0044183) and from carrier-holdase activity (GO:0140309).
Justification: HSPB1 is an ATP-independent small heat shock protein that keeps denatured proteins in a folding-competent state. Obsolete GO:0051082 captured binding only; GO:0044183 requires assisting folding, and GO:0140309 ('unfolded protein holdase activity') keeps a carrier-specific definition requiring escort to an acceptor molecule or location. Same proposal as in the C. elegans hsp-16.1/16.41/16.48 reviews; see go-ontology#30552.
Parent term: molecular_function
Supporting Evidence:
| GO Term | Evidence | Action | Reason |
|---|---|---|---|
| GO:0000502 proteasome complex | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS transfer of proteasome complex localization. Reason: HSPB1 can bind ubiquitin chains and promote degradation of selected clients, but it is not a proteasome subunit; association with the proteasome is a client-delivery interaction, not complex membership. |
| GO:0001533 cornified envelope | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ARBA-predicted cornified envelope localization. Reason: HSPB1 is abundant in differentiating keratinocytes; plausible but tissue-specific and not core. |
| GO:0001932 regulation of protein phosphorylation | IMP PMID:23728742 Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-me... | KEEP AS NON CORE | Summary: CMT-causing HSPB1 mutants increase Cdk5-mediated neurofilament phosphorylation. Reason: Effect on client (neurofilament) phosphorylation reflects chaperone action on neurofilaments; disease-relevant but not core. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins |
| GO:0003723 RNA binding | HDA PMID:22658674 Insights into RNA biology from an atlas of mammalian mRNA-bi... | MARK AS OVER ANNOTATED | Summary: Detected in a HeLa mRNA interactome capture screen. Reason: High-throughput UV-crosslinking detection only; HSPB1 is not an established RNA-binding protein. |
| GO:0005080 protein kinase C binding | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported binding to protein kinase C (ISS/ARBA). Reason: Limited evidence; regulatory interaction rather than a core HSPB1 activity. |
| GO:0005080 protein kinase C binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Reported binding to protein kinase C (ISS/ARBA). Reason: Limited evidence; regulatory interaction rather than a core HSPB1 activity. |
| GO:0005515 protein binding | IPI PMID:11003656 Inhibition of Daxx-mediated apoptosis by heat shock protein ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:12601044 Alteration of protein-protein interactions of congenital cat... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:12601044 Alteration of protein-protein interactions of congenital cat... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:14594798 Interaction of human HSP22 (HSPB8) with other small heat sho... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:15161933 Comprehensive proteomic analysis of interphase and mitotic 1... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:16169070 A human protein-protein interaction network: a resource for ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:17184779 Identification of differential proteins in nasopharyngeal ca... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:17342744 HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer c... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:18330356 Construction and characterization of a normalized yeast two-... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:20467437 Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:20618440 Proteomic and biochemical analysis of 14-3-3-binding protein... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:21157431 ATM activates the pentose phosphate pathway promoting anti-o... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:21575178 Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAP... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:21575178 Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAP... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:21575178 Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAP... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:23188086 Binding determinants of the small heat shock protein, Ξ±B-cry... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:23948568 Structure and properties of G84R and L99M mutants of human s... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25036637 A quantitative chaperone interaction network reveals the arc... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25241761 Using an in situ proximity ligation assay to systematically ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:26496610 A human interactome in three quantitative dimensions organiz... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:28514442 Architecture of the human interactome defines protein commun... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:32814053 Interactome Mapping Provides a Network of Neurodegenerative ... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:33961781 Dual proteome-scale networks reveal cell-specific remodeling... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:37776851 Analysis of proteome-wide degradation dynamics in ALS SOD1 i... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005515 protein binding | IPI PMID:40205054 Multimodal cell maps as a foundation for structural and func... | REMOVE | Summary: Generic protein binding (IPI), largely from high-throughput interactome and chaperone-network screens. Reason: Uninformative term; HSPB1 binds many clients and partners as a chaperone. Informative aspects are captured by protein folding chaperone and identical protein binding. Removal does not imply the reported interactions are false. |
| GO:0005576 extracellular region | HDA PMID:22664934 Comparison of tear protein levels in breast cancer patients ... | KEEP AS NON CORE | Summary: Detected in tear-fluid proteomes. Reason: HSPB1 can be released from cells; a minor, high-throughput location. |
| GO:0005576 extracellular region | HDA PMID:23580065 Shotgun proteomics reveals specific modulated protein patter... | KEEP AS NON CORE | Summary: Detected in tear-fluid proteomes. Reason: HSPB1 can be released from cells; a minor, high-throughput location. |
| GO:0005634 nucleus | IBA GO_REF:0000033 | ACCEPT | Summary: HSPB1 translocates to the nucleus (SC35 speckles) during heat shock. Reason: Supported stress-dependent location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005634 nucleus | IDA PMID:19464326 HSPB7 is a SC35 speckle resident small heat shock protein. | ACCEPT | Summary: HSPB1 translocates to the nucleus (SC35 speckles) during heat shock. Reason: Supported stress-dependent location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005634 nucleus | IEA GO_REF:0000120 | ACCEPT | Summary: HSPB1 translocates to the nucleus (SC35 speckles) during heat shock. Reason: Supported stress-dependent location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | EXP PMID:10777697 Small heat shock protein 27 (HSP27) associates with tubulin/... | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | IBA GO_REF:0000033 | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | IDA PMID:18005709 The Bacillus subtilis quorum-sensing molecule CSF contribute... | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | IDA PMID:19464326 HSPB7 is a SC35 speckle resident small heat shock protein. | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | IDA PMID:28144995 Axonal Neuropathies due to Mutations in Small Heat Shock Pro... | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | IEA GO_REF:0000120 | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | TAS PMID:10859165 Chaperone hsp27 inhibits translation during heat shock by bi... | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005737 cytoplasm | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | ACCEPT | Summary: HSPB1 is cytoplasmic in interphase cells. Reason: Principal location. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005819 spindle | IEA GO_REF:0000044 | KEEP AS NON CORE | Summary: HSPB1 colocalizes with mitotic spindles. Reason: Minor localization. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. PMID:10777697 These results indicate that HSP27 associates with tubulin/microtubules in HeLa cells. |
| GO:0005829 cytosol | IDA GO_REF:0000052 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-450551 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-450580 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5218916 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-5687121 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9021050 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005829 cytosol | TAS Reactome:R-HSA-9021072 | ACCEPT | Summary: Cytosolic localization (HPA, Reactome). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| GO:0005856 cytoskeleton | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | ACCEPT | Summary: HSPB1 associates with the actin and microtubule cytoskeleton. Reason: Consistent with its roles in actin organization and tubulin association. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Plays a role in stress resistance and actin organization PMID:10777697 These results indicate that HSP27 associates with tubulin/microtubules in HeLa cells. |
| GO:0005886 plasma membrane | IDA GO_REF:0000052 | KEEP AS NON CORE | Summary: Plasma membrane signal in HPA immunofluorescence / ARBA. Reason: Likely cortical/actin-associated pool; not core. |
| GO:0005886 plasma membrane | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Plasma membrane signal in HPA immunofluorescence / ARBA. Reason: Likely cortical/actin-associated pool; not core. |
| GO:0005925 focal adhesion | HDA PMID:21423176 Analysis of the myosin-II-responsive focal adhesion proteome... | KEEP AS NON CORE | Summary: Identified in the focal adhesion proteome. Reason: Consistent with actin association; high-throughput only. |
| GO:0006446 regulation of translational initiation | TAS PMID:10859165 Chaperone hsp27 inhibits translation during heat shock by bi... | KEEP AS NON CORE | Summary: Hsp27 binds eIF4G during heat shock and inhibits cap-dependent translation initiation. Reason: Specific stress-time role; not core. Supporting Evidence: PMID:10859165 We demonstrate that chaperone Hsp27 is a heat shock-induced inhibitor of cellular protein synthesis. |
| GO:0006457 protein folding | IMP PMID:20178975 Increased monomerization of mutant HSPB1 leads to protein hy... | ACCEPT | Summary: HSPB1 chaperone activity (CMT mutants show altered chaperone activity in assays). Reason: HSPB1 is an ATP-independent chaperone that prevents aggregation of non-native proteins and holds them for HSP70-dependent refolding. Supporting Evidence: PMID:20178975 In contrast to other chaperonopathies, our results revealed that particular HSPB1 mutations presented higher chaperone activity compared with wild type. file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state |
| GO:0006457 protein folding | IMP PMID:23948568 Structure and properties of G84R and L99M mutants of human s... | ACCEPT | Summary: HSPB1 chaperone activity (CMT mutants show altered chaperone activity in assays). Reason: HSPB1 is an ATP-independent chaperone that prevents aggregation of non-native proteins and holds them for HSP70-dependent refolding. Supporting Evidence: PMID:20178975 In contrast to other chaperonopathies, our results revealed that particular HSPB1 mutations presented higher chaperone activity compared with wild type. file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state |
| GO:0006986 response to unfolded protein | NAS PMID:1560006 Copurification of small heat shock protein with alpha B crys... | ACCEPT | Summary: HSPB1 is part of the cellular response to unfolded proteins as a stress-induced chaperone. Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state file:human/HSPB1/HSPB1-uniprot.txt Up-regulated in response to environmental stresses such as heat shock |
| GO:0006986 response to unfolded protein | TAS PMID:10859165 Chaperone hsp27 inhibits translation during heat shock by bi... | ACCEPT | Summary: HSPB1 is part of the cellular response to unfolded proteins as a stress-induced chaperone. Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state file:human/HSPB1/HSPB1-uniprot.txt Up-regulated in response to environmental stresses such as heat shock |
| GO:0008426 protein kinase C inhibitor activity | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: ISS/ARBA transfer of protein kinase C inhibitor activity. Reason: No direct human evidence; HSPB1 is not established as an enzyme inhibitor of PKC, and the inferred activity is likely an over-interpretation of a regulatory interaction. |
| GO:0008426 protein kinase C inhibitor activity | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS/ARBA transfer of protein kinase C inhibitor activity. Reason: No direct human evidence; HSPB1 is not established as an enzyme inhibitor of PKC, and the inferred activity is likely an over-interpretation of a regulatory interaction. |
| GO:0009408 response to heat | IBA GO_REF:0000033 | ACCEPT | Summary: HSPB1 is heat-inducible and protects cells against heat stress. Reason: Core stress-response role; IBA consistent with sHSP family. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Up-regulated in response to environmental stresses such as heat shock file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state |
| GO:0009615 response to virus | IEP PMID:16548883 Transcriptomic and proteomic analyses of rhabdomyosarcoma ce... | MARK AS OVER ANNOTATED | Summary: HSPB1 levels change upon enterovirus 71 infection (IEP). Reason: Expression change only; no evidence that HSPB1 acts in an antiviral response. |
| GO:0010506 regulation of autophagy | NAS PMID:25962073 Small Heat Shock Protein Beta-1 (HSPB1) Is Upregulated and R... | KEEP AS NON CORE | Summary: HSPB1 is upregulated and regulates autophagy in renal tubular cells after injury (NAS). Reason: Non-core, context-specific. |
| GO:0019901 protein kinase binding | IPI PMID:8774846 A comparison of the substrate specificity of MAPKAP kinase-2... | KEEP AS NON CORE | Summary: HSPB1 binds and is phosphorylated by MAPKAPK2/3. Reason: HSPB1 is a substrate of these kinases; binding reflects regulation of HSPB1. Supporting Evidence: PMID:8774846 MAPKAP kinase-3 and MAPKAP kinase-2 phosphorylated peptide substrates with similar kinetic constants and phosphorylated the same serine residues in HSP27 at the same relative rates. file:human/HSPB1/HSPB1-uniprot.txt Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. |
| GO:0019901 protein kinase binding | IPI PMID:8774846 A comparison of the substrate specificity of MAPKAP kinase-2... | KEEP AS NON CORE | Summary: HSPB1 binds and is phosphorylated by MAPKAPK2/3. Reason: HSPB1 is a substrate of these kinases; binding reflects regulation of HSPB1. Supporting Evidence: PMID:8774846 MAPKAP kinase-3 and MAPKAP kinase-2 phosphorylated peptide substrates with similar kinetic constants and phosphorylated the same serine residues in HSP27 at the same relative rates. file:human/HSPB1/HSPB1-uniprot.txt Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. |
| GO:0030018 Z disc | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ARBA-predicted Z disc localization. Reason: Muscle-specific localization consistent with high expression in striated muscle; not core. |
| GO:0032731 positive regulation of interleukin-1 beta production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported positive regulation of IL-1beta production (ISS). Reason: Signalling-level, indirect role. |
| GO:0032731 positive regulation of interleukin-1 beta production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Reported positive regulation of IL-1beta production (ISS). Reason: Signalling-level, indirect role. |
| GO:0032760 positive regulation of tumor necrosis factor production | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported positive regulation of TNF production (ISS). Reason: Signalling-level, indirect role. |
| GO:0032760 positive regulation of tumor necrosis factor production | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Reported positive regulation of TNF production (ISS). Reason: Signalling-level, indirect role. |
| GO:0035556 intracellular signal transduction | IMP PMID:18440775 Vascular endothelial growth factor induces heat shock protei... | MARK AS OVER ANNOTATED | Summary: HSP27 is phosphorylated downstream of VEGF-PKD signalling in endothelial cells. Reason: HSPB1 is a phospho-target/effector; a generic intracellular signal transduction term overstates its role. Supporting Evidence: PMID:18440775 Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced HUVEC migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF. |
| GO:0035924 cellular response to vascular endothelial growth factor stimulus | IMP PMID:18440775 Vascular endothelial growth factor induces heat shock protei... | KEEP AS NON CORE | Summary: HSP27 knockdown inhibits VEGF-induced endothelial migration. Reason: Context-specific effector role. Supporting Evidence: PMID:18440775 Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced HUVEC migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF. |
| GO:0042026 protein refolding | IBA GO_REF:0000033 | MARK AS OVER ANNOTATED | Summary: PAINT IBA for protein refolding from node PTN000897708. HSPB1 is an ATP-independent small heat shock protein holdase that maintains denatured client proteins in a folding-competent state rather than catalyzing protein refolding itself. Reason: HSPB1 is an ATP-independent holdase chaperone that binds unfolding intermediates to prevent irreversible aggregation and hold them in a refolding-competent state until ATP-dependent HSP70 machinery catalyzes refolding. Although GO:0042026 (protein refolding) is a biological process term, sHSP holdase sequestration occurs during stress to prevent irreversible aggregation independently of whether the client's downstream fate is HSP70-mediated refolding or proteasomal/autophagic degradation, and sHSPs are neither subunits nor cofactors of the ATP-dependent HSP70/J-domain/NEF refolding reaction once substrate is released, so attributing the downstream protein refolding process (GO:0042026) to the upstream stress holdase conflates distinct proteostasis steps (go-ontology#30552), as noted in proposed_new_terms for holdase chaperone activity. Marked as over-annotated, consistent with sibling human, zebrafish, and C. elegans sHSP reviews. Propagation Review Root cause: TERM SCOPING PROBLEM Failure modes: ROLE CONFLATION GRANULARITY MISMATCH Sources checked: PANTHER:PTN000897708 Β· PTN000897708 SUPPORTS SOURCE BUT NOT TARGET Ancestral sHSP node placement (Eumetazoa, taxon:6072) is sound for chaperone-like holdase function, but GO:0042026 (protein refolding) ascribes to the sHSP an active foldase step performed by ATP-dependent chaperone machinery rather than HSPB1's ATP-independent holdase sequestration. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state |
| GO:0042802 identical protein binding | EXP PMID:31573509 Interplay of disordered and ordered regions of a human small... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IMP PMID:20178975 Increased monomerization of mutant HSPB1 leads to protein hy... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IMP PMID:23948568 Structure and properties of G84R and L99M mutants of human s... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IPI PMID:11003656 Inhibition of Daxx-mediated apoptosis by heat shock protein ... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IPI PMID:15581903 Self-association of a small heat shock protein. | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IPI PMID:22365833 Dynamic protein-protein interaction wiring of the human spli... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IPI PMID:25036637 A quantitative chaperone interaction network reveals the arc... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042802 identical protein binding | IPI PMID:25277244 The functional landscape of Hsp27 reveals new cellular proce... | ACCEPT | Summary: HSPB1 self-associates into dimers and large dynamic oligomers whose assembly state controls its chaperone activity. Reason: Oligomerization is mechanistically central for sHSPs. Supporting Evidence: PMID:15581903 Human Hsp27 oligomerizes in vivo in a phosphorylation-dependent manner that regulates the functional activity of the protein. file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0042803 protein homodimerization activity | IDA PMID:28144995 Axonal Neuropathies due to Mutations in Small Heat Shock Pro... | ACCEPT | Summary: HSPB1 forms homodimers (the basic building block of its oligomers). Reason: Correct. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Homooligomer (PubMed:10383393). Homodimer; becomes monomeric upon activation (PubMed:20178975). |
| GO:0043066 negative regulation of apoptotic process | IBA GO_REF:0000033 | ACCEPT | Summary: HSPB1 protects cells from apoptosis (e.g. by blocking DAXX-mediated apoptosis). Reason: Well-established cytoprotective role; IBA consistent. Supporting Evidence: PMID:11003656 Here we show that phosphorylated dimers of HSP27 interact with Daxx, a mediator of Fas-induced apoptosis, preventing the interaction of Daxx with both Ask1 and Fas and blocking Daxx-mediated apoptosis. |
| GO:0043066 negative regulation of apoptotic process | TAS PMID:16130169 Proteomics of human umbilical vein endothelial cells applied... | ACCEPT | Summary: HSPB1 protects cells from apoptosis (e.g. by blocking DAXX-mediated apoptosis). Reason: Well-established cytoprotective role; IBA consistent. Supporting Evidence: PMID:11003656 Here we show that phosphorylated dimers of HSP27 interact with Daxx, a mediator of Fas-induced apoptosis, preventing the interaction of Daxx with both Ask1 and Fas and blocking Daxx-mediated apoptosis. |
| GO:0043122 regulation of canonical NF-kappaB signal transduction | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: Reported regulation of NF-kappaB signalling (ISS/ARBA). Reason: Indirect signalling role. |
| GO:0043122 regulation of canonical NF-kappaB signal transduction | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: Reported regulation of NF-kappaB signalling (ISS/ARBA). Reason: Indirect signalling role. |
| GO:0043130 ubiquitin binding | ISS GO_REF:0000024 | KEEP AS NON CORE | Summary: HSPB1 binds polyubiquitin chains (ISS). Reason: Plausible role in delivering clients for degradation; not core. |
| GO:0043292 contractile muscle fiber | IEA GO_REF:0000107 | KEEP AS NON CORE | Summary: ARBA-predicted contractile muscle fiber localization. Reason: Muscle-specific localization; not core. |
| GO:0043536 positive regulation of blood vessel endothelial cell migration | IMP PMID:18440775 Vascular endothelial growth factor induces heat shock protei... | KEEP AS NON CORE | Summary: HSP27 knockdown inhibits VEGF-induced endothelial cell migration. Reason: Context-specific effector role. Supporting Evidence: PMID:18440775 Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced HUVEC migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF. |
| GO:0044183 protein folding chaperone | IEA GO_REF:0000107 | MODIFY | Summary: HSPB1 is an ATP-independent chaperone that binds non-native proteins and prevents their aggregation. Reason: Core molecular function, but HSPB1 is an ATP-independent holdase that suppresses aggregation and keeps clients refolding-competent rather than itself assisting folding, which GO:0044183 implies. Unfolded protein binding (GO:0051082) is obsolete and GO:0140309 keeps a carrier-specific definition, so, as for the C. elegans HSP-16 sHSPs (hsp-16.1, hsp-16.41, hsp-16.48 reviews) and go-ontology#30552, the replacement is the proposed holdase chaperone activity NTR. Proposed replacements: holdase chaperone activity Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state PMID:20178975 In contrast to other chaperonopathies, our results revealed that particular HSPB1 mutations presented higher chaperone activity compared with wild type. |
| GO:0044183 protein folding chaperone | IMP PMID:20178975 Increased monomerization of mutant HSPB1 leads to protein hy... | MODIFY | Summary: HSPB1 is an ATP-independent chaperone that binds non-native proteins and prevents their aggregation. Reason: Core molecular function, but HSPB1 is an ATP-independent holdase that suppresses aggregation and keeps clients refolding-competent rather than itself assisting folding, which GO:0044183 implies. Unfolded protein binding (GO:0051082) is obsolete and GO:0140309 keeps a carrier-specific definition, so, as for the C. elegans HSP-16 sHSPs (hsp-16.1, hsp-16.41, hsp-16.48 reviews) and go-ontology#30552, the replacement is the proposed holdase chaperone activity NTR. Proposed replacements: holdase chaperone activity Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state PMID:20178975 In contrast to other chaperonopathies, our results revealed that particular HSPB1 mutations presented higher chaperone activity compared with wild type. |
| GO:0045766 positive regulation of angiogenesis | IMP PMID:18440775 Vascular endothelial growth factor induces heat shock protei... | KEEP AS NON CORE | Summary: HSP27 knockdown inhibits VEGF-induced tubulogenesis. Reason: Context-specific effector role. Supporting Evidence: PMID:18440775 Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced HUVEC migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF. |
| GO:0048010 vascular endothelial growth factor receptor signaling pathway | IMP PMID:18440775 Vascular endothelial growth factor induces heat shock protei... | KEEP AS NON CORE | Summary: HSP27 is a phosphorylated effector required for VEGF-induced endothelial responses. Reason: Downstream effector; not core. Supporting Evidence: PMID:18440775 Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced HUVEC migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF. |
| GO:0050821 protein stabilization | IEA GO_REF:0000107 | ACCEPT | Summary: ARBA-predicted protein stabilization. Reason: Consistent with chaperone activity preventing client aggregation/degradation. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state |
| GO:0060729 intestinal epithelial structure maintenance | IDA PMID:18005709 The Bacillus subtilis quorum-sensing molecule CSF contribute... | KEEP AS NON CORE | Summary: Hsp induction (including HSP27) by a bacterial quorum-sensing peptide protects intestinal epithelial barrier. Reason: Indirect, context-specific. |
| GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding | IPI PMID:10386584 Cloning and characterization of hGMEB1, a novel glucocortico... | MARK AS OVER ANNOTATED | Summary: GMEB1 was cloned as an HSP27-interacting protein in a yeast two-hybrid screen. Reason: Single Y2H interaction; HSPB1 is not an established transcription coregulator. Supporting Evidence: PMID:10386584 Using heat shock protein 27 (HSP27) as bait in the yeast two-hybrid assay, we cloned a 1.83-kb cDNA encoding a novel 573-amino acid protein called human GMEB1 (hGMEB1). |
| GO:0070062 extracellular exosome | HDA PMID:19056867 Large-scale proteomics and phosphoproteomics of urinary exos... | KEEP AS NON CORE | Summary: Detected in exosome proteomes. Reason: High-throughput; minor extracellular pool. |
| GO:0070062 extracellular exosome | HDA PMID:19199708 Proteomic analysis of human parotid gland exosomes by multid... | KEEP AS NON CORE | Summary: Detected in exosome proteomes. Reason: High-throughput; minor extracellular pool. |
| GO:0070062 extracellular exosome | HDA PMID:23533145 In-depth proteomic analyses of exosomes isolated from expres... | KEEP AS NON CORE | Summary: Detected in exosome proteomes. Reason: High-throughput; minor extracellular pool. |
| GO:0070527 platelet aggregation | HMP PMID:23382103 Platelet proteome analysis reveals integrin-dependent aggreg... | MARK AS OVER ANNOTATED | Summary: Lower platelet HSPB1 levels correlated with aggregation defects in a proteome study (HMP). Reason: Correlative proteomic evidence; no demonstrated HSPB1 function in platelet aggregation. |
| GO:0090038 negative regulation of protein kinase C signaling | IEA GO_REF:0000107 | MARK AS OVER ANNOTATED | Summary: ISS/ARBA transfer of negative regulation of PKC signalling. Reason: Weak, indirect evidence; not supported by direct human data. |
| GO:0090038 negative regulation of protein kinase C signaling | ISS GO_REF:0000024 | MARK AS OVER ANNOTATED | Summary: ISS/ARBA transfer of negative regulation of PKC signalling. Reason: Weak, indirect evidence; not supported by direct human data. |
| GO:0099641 anterograde axonal protein transport | IMP PMID:23728742 Charcot-Marie-Tooth causing HSPB1 mutations increase Cdk5-me... | KEEP AS NON CORE | Summary: CMT-associated HSPB1 mutants impair neurofilament axonal transport. Reason: Disease-relevant consequence of chaperone action on neurofilaments. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins |
| GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | IDA PMID:20178975 Increased monomerization of mutant HSPB1 leads to protein hy... | ACCEPT | Summary: HSPB1 protects against oxidative stress-induced apoptosis; CMT mutants retain/increase this protection. Reason: Consistent with the well-established cytoprotective role. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. |
| GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | IEA GO_REF:0000107 | ACCEPT | Summary: HSPB1 protects against oxidative stress-induced apoptosis; CMT mutants retain/increase this protection. Reason: Consistent with the well-established cytoprotective role. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. |
| GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | ISS GO_REF:0000024 | ACCEPT | Summary: HSPB1 protects against oxidative stress-induced apoptosis; CMT mutants retain/increase this protection. Reason: Consistent with the well-established cytoprotective role. Supporting Evidence: file:human/HSPB1/HSPB1-uniprot.txt Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. |
| GO:1904115 axon cytoplasm | IEA GO_REF:0000108 | KEEP AS NON CORE | Summary: Inferred axon cytoplasm localization. Reason: Consistent with neuronal role; not core. |
| GO:2001028 positive regulation of endothelial cell chemotaxis | IMP PMID:18440775 Vascular endothelial growth factor induces heat shock protei... | KEEP AS NON CORE | Summary: HSP27 knockdown inhibits VEGF-induced chemotaxis of endothelial cells. Reason: Context-specific effector role. Supporting Evidence: PMID:18440775 Knockdown of HSP27 and PKDs markedly inhibited VEGF-induced HUVEC migration and tubulogenesis, whereas inhibition of the p38 kinase pathway using either SB203580 or siRNAs against p38alpha or MAPKAPK2, had no significant effect on the chemotactic response to VEGF. |
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Download this section (compressed HTML)Q: How does phosphorylation-driven remodelling of HSPB1 oligomers change client selection versus anti-apoptotic partner binding in vivo?
Q: Do CMT2F/dHMN HSPB1 variants act through gain of chaperone activity, altered oligomer dynamics, or loss of cytoskeletal (neurofilament/microtubule) function?
Experiment: Proximity labelling or crosslinking mass spectrometry of HSPB1 phospho-variants in HSPB1-null cells before and after heat shock, coupled to aggregation proteomics.
Hypothesis: Phosphomimetic and non-phosphorylatable HSPB1 differ in which endogenous clients they protect from heat-induced aggregation.
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